CN110146587A - The online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample - Google Patents
The online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample Download PDFInfo
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- CN110146587A CN110146587A CN201910547492.9A CN201910547492A CN110146587A CN 110146587 A CN110146587 A CN 110146587A CN 201910547492 A CN201910547492 A CN 201910547492A CN 110146587 A CN110146587 A CN 110146587A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/64—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode using wave or particle radiation to ionise a gas, e.g. in an ionisation chamber
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Abstract
The online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample, using portable ion trap mass spectrometer and common film input mode, on-line mass spectroscopy research and application is provided for volatile small molecule metabolin (boiling point≤300 DEG C) in plant, animal and human tissue specimens, can be used for the live mass spectral analysis identification outside the kinds of experiments rooms such as tumour real-time diagnosis in art, Materia Medica Identification, food adulteration detection, food and medicine quality and safety control.It performs the operation indoor tumor tissues real-time diagnosis, can be used as ancillary technique, improve the accuracy of clinical diagnosis, promote modern accurate medical research.The real-time analysis detection of food and medicine, department is controlled for food and medicine supervisory and management department, health and epidemic prevention, inspection and quarantining for import/export or enterprise-quality and provides important and scientific on-site test means, promotes the management and modernization supervision and management of food and drug safety.
Description
Technical field
Present invention relates particularly to mass spectral analysis detection technique fields, and in particular to volatility metabolism produces in a kind of tissue sample
The online portable mass spectrometer of object.
Background technique
Mass spectral analysis is a kind of very important research method, has been widely used in biomedicine, pharmacy, food at present
The multidisciplinary researches such as science field.Tissue samples (animal, plant, tissue etc.) are generally required by homogenate (powder
It is broken), extracting and developing, the complicated cumbersome sample pretreatment process such as enrichment and purifying, mass spectral analysis could be used for.Open type is normal
Piezoelectricity can be under atmospheric pressure environment to tissue sample from mass-spectrometric technique (Ambient Ionization Mass Spectrometry)
Complicated cumbersome sample pretreatment process is saved in this progress direct ionization mass spectral analysis, and then meets the real-time analysis detection in scene
Demand, opened up a new way for the monitoring of real-time mass spectrum and high-throughput mass spectral analysis.Open type atmospheric pressure ionization mass spectroscopy is with desorption
LC-MS spectrometry (Desporption Electrospray Ionization MS, DESI-MS) and rapid steaming power generation
It is representative from mass spectrum (Rapid Evaporative Ionization Mass Spectrometry, REIMS), is based primarily upon
The principle of electrospray ionisation (Electrospray Ionization, ESI), for analyzing organic acid in tissue sample, amino
Acid, alkaloid, fatty acid, phosphatide, polypeptide, protein isopolarity or moderately polar not volatile metabolite, are ionized
The limitation of mode and ionizing energy is not possible to realize in tissue sample that the metabolism of the volatile small molecules such as alkanes, esters, ketone produces
The direct ionization mass spectral analysis of object detects.Moreover, its bulky, expensive, Operation and Maintenance mistake of laboratory conventional mass spectrometer
Journey is complicated, often cannot be used directly for the on-line analysis monitoring of tissue sample.
Summary of the invention
It is in order to solve the defects of prior art and insufficient.The present invention provides volatile small molecule generations in a kind of tissue sample
Thank to the online portable mass spectrometer of product.
The technical solution that the present invention uses is: in a kind of tissue sample volatile small molecule metabolite it is online just
Mass spectrometer is taken, the online portable mass spectrometer successively includes sampling device and portable ion trap mass spectrometry
Instrument, the sampling device successively include the filter device of injection port, the solid for filtering out bulky grain or drop with
And transfer conduit, the feed end of the transfer conduit are connected with filter device, the discharge end of the transfer conduit with it is portable
Ion trap mass spectrometer is connected, and high temperature collision heater strip is additionally provided between the transfer conduit and portable ion trap mass spectrometer and is gathered
Dimethyl siloxane membrane structure.
The filter device includes a filter chamber, and the filter chamber is equipped with air inlet pipeline and outlet pipe, described
Air inlet pipeline and the bottom of outlet pipe be inserted into filter chamber, the air inlet pipeline is connected with injection port, and described goes out
Air pipe is connected with transfer conduit.
The air inlet pipeline and outlet pipe is vertical and arranged in parallel, the air inlet pipe being inserted into filter chamber
The bottom on road is lower than the bottom level of outlet pipe.
The air inlet pipeline and outlet pipe is arranged horizontally and mutually in parallel, and the air inlet pipeline is located at outlet pipe
Bottom.
The injection port, which is equipped with, locally to generate high fuel factor in tissue sample in a short time, make animal tissue
Albuminous degeneration solidification, Volatile Metabolites moment volatilization, generates smoke the area heating installation of gas or aerosol.
Being additionally provided on the outside of the air inlet pipeline and outlet pipe can further promote to remain in smog gas or aerosol
The Quick-gasifying of a small amount of solid small particles or drop further increases the auxiliary heating for the gas sample amount that can be used for mass spectral analysis
Device, the assisted heating device are wrapped on the outer wall of air inlet pipeline and outlet pipe.
In portable ion trap mass spectrometer sample introduction interface, it can also be equipped with high temperature and collide heater strip, the high-temperature heating silk is adopted
It is made of iron-nickel-chromium, up to 500 degree or more, swiftly flowing smog gas or aerosol sample touch heating temperature with high-temperature heating
It hits, further promotes the evaporation of solid particle or drop gasification, smoke-purifying fog or aerosol sample, avoid or reduce smog gas
Or aerosol sample improves the ionization effect of sample to the pollution inside PDMS membrane and portable ion trap mass spectrometry
Rate.
The beneficial effects of the present invention are: the present invention provides in a kind of tissue sample volatile small molecule metabolite
The portable mass spectrometer of line is plant, animal and human body using portable ion trap mass spectrometer and common film input mode
Volatile small molecule metabolin (boiling point≤300 DEG C) provides on-line mass spectroscopy research and application in tissue sample, can be used in art swelling
Live matter outside the kinds of experiments rooms such as tumor real-time diagnosis, Materia Medica Identification, food adulteration detection, food and medicine quality and safety control
Spectrum analysis identification.It performs the operation indoor tumor tissues real-time diagnosis, can be used as ancillary technique, improve the accuracy of clinical diagnosis,
Promote modern accurate medical research.The real-time analysis detection of food and medicine, be food and medicine supervisory and management department, health and epidemic prevention,
Inspection and quarantining for import/export or enterprise-quality control department provide important and scientific on-site test means, promote food and medicine
The management and modernization supervision and management of safety.
Detailed description of the invention
Fig. 1 is the online portable mass spectrometer structural schematic diagram of the present invention.
Fig. 2 is filter apparatus configuration schematic diagram of the present invention.
Fig. 3 is filter apparatus configuration schematic diagram of the present invention.
Fig. 4 is transfer conduit of the present invention and high-temperature heating silk structural schematic diagram.
The portable ion trap mass spectrometer of 1- in figure, 2- injection port, 3- transfer conduit, 4- filter device, 41- filter chamber, 42- into
Air pipe, 43- outlet pipe.
Specific embodiment
In order to be more clearly understood that technology contents of the invention, spy lifts following embodiment and is described in detail.
As shown in Figure 1, Figure 2, Figure 3, Figure 4, in a kind of tissue sample volatile small molecule metabolite online portable matter
Spectrum analysis device, the online portable mass spectrometer successively include sampling device and portable ion trap mass spectrometer 1, institute
The sampling device stated successively includes injection port 2, the filter device 4 of the solid for filtering out bulky grain or drop and biography
The feed end of defeated pipeline 3, the transfer conduit 3 is connected with filter device 4, the discharge end of the transfer conduit 3 with it is portable
Ion trap mass spectrometer 1 is connected, and is additionally provided with dimethyl silicone polymer between the transfer conduit 3 and portable ion trap mass spectrometer 1
Membrane structure.The sampling device of portable ion trap mass spectrometer uses common film input mode, by sieve, dimethyl silicone polymer
(PDMS) film is constituted.Sieve can further be filtered smog gas or aerosol.To further decrease or avoiding to reach mass spectrum
The influence of granular solid or drop in smog gas or aerosol at injection port.The effect of PDMS membrane is filter
H in smoke abatement fog or aerosol2O, N2, O2Inorganic matter other than equal volatile organic matters, and have one to volatile organic matter
Fixed enrichment.
The filter device 4 includes a filter chamber 41, and the filter chamber 41 is equipped with air inlet pipeline 42 and escape pipe
The bottom of road 43, the air inlet pipeline 42 and outlet pipe 43 is inserted into filter chamber 41, the air inlet pipeline 42 with into
Sample mouth 2 is connected, and the outlet pipe 43 is connected with transfer conduit 3.It is mainly used for filtering out the solid of bulky grain or drop, reduces
Pipeline pollution.Using the strainer or membrane filtration of different pore size, such as customize the PET(Polyethylene of processing
Terephthalate) HEPA (High efficiency particulate air Filter) high efficiency particulate air of material,
Filter out the particle that diameter is greater than 1.0 microns.Referring to the principle of cold-trap and sedimentation, following Fig. 2 can also be designed, two kinds of devices of B3,
Further eliminate smog gas or bulky grain solid or drop in aerosol.Meanwhile the device can be heated suitably to improve smog
Gas or aerosol sample efficiency of transmission.
The air inlet pipeline 42 and outlet pipe 43 is vertical and arranged in parallel, is inserted into described in filter chamber 41
The bottom of air inlet pipeline 42 is lower than the bottom level of outlet pipe 43.
The air inlet pipeline 42 and outlet pipe 43 is arranged horizontally and mutually in parallel, and the air inlet pipeline 42 is located at
The bottom of air pipe 43.
The injection port 2, which is equipped with, locally to generate high fuel factor in tissue sample in a short time, make animal tissue
Albuminous degeneration solidification, Volatile Metabolites moment volatilization, the area heating installation of gas or aerosol is generated smoke, using height
The modes such as frequency electric knife (medical), laser, micro-wave scalpel, electric iron.
The outside of the air inlet pipeline 42 and outlet pipe 43 is additionally provided with and can further promote in smog gas or aerosol
The Quick-gasifying for remaining a small amount of solid small particles or drop further increases the auxiliary that can be used for the gas sample amount of mass spectral analysis
Heating device, the assisted heating device is wrapped on the outer wall of air inlet pipeline 42 and outlet pipe 43, and heating temperature can
It adjusts, when preventing temperature from reducing, precipitation of the higher boiling Volatile Metabolites in pipeline.
It can also be equipped with high temperature in the sample interface of the portable ion trap mass spectrometer 1 and collide heater strip, heating temperature reaches
500 degree or more, swiftly flowing smog gas or aerosol sample and high-temperature heating collide, further to promote solid particle or liquid
The evaporation of drop is gasified, and smoke-purifying fog or aerosol sample avoid or reduce smog gas or aerosol sample to poly dimethyl silicon
Pollution inside siloxane film and portable ion trap mass spectrometry, improves the Ionization Efficiency of sample.
The smog gas or aerosol that the aspiration pump of the sample introduction interface of portable mass spectrograph 1 generates tissue sample local heating
Quickly introduce heat transfer pipeline.
Portable ion trap mass spectrometer need under normal atmospheric environment can one man operation, main screw lift suggestion 20kg with
It is interior, mainly it is made of electron bombardment EI (Electron Impact) ionization source, ion strap mass analyzer, ion detector.
Wherein electron impact ionization source is used for the ionization and fragmentation of volatile small molecule organic matter, to obtain the mass signal of ion.
In the description of the present invention, it should be noted that term " center ", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom" "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of description of the present invention and simplification of the description, rather than instruction or dark
Show that signified device or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as pair
Limitation of the invention.In addition, term " first ", " second " are used for description purposes only, it is not understood to indicate or imply opposite
Importance.In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.In addition, in the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two or two
More than.Every technical staff's notice: although the present invention is described according to above-mentioned specific embodiment, hair of the invention
Bright thought is not limited in the invention, and it is special will to be all included in this patent for any repacking with inventive concept
In economic rights protection scope.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (7)
1. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample, which is characterized in that it is described
The portable mass spectrometer of line successively includes sampling device and portable ion trap mass spectrometer (1), and the sampling device is successively
It include the filter device (4) and transfer conduit (3) of injection port (2), the solid for filtering out bulky grain or drop, institute
The feed end for the transfer conduit (3) stated is connected with filter device (4), the discharge end and portable ion of the transfer conduit (3)
Trap mass spectrograph (1) is connected, and high temperature collision heating is additionally provided between the transfer conduit (3) and portable ion trap mass spectrometer (1)
Silk and PDMS membrane structure.
2. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 1,
It is characterized in that, the filter device (4) includes a filter chamber (41), the filter chamber (41) is equipped with air inlet pipeline
(42) and outlet pipe (43), the bottom of the air inlet pipeline (42) and outlet pipe (43) is inserted into filter chamber (41),
The air inlet pipeline (42) is connected with injection port (2), and the outlet pipe (43) is connected with transfer conduit (3).
3. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 2,
It is characterized in that, the air inlet pipeline (42) and outlet pipe (43) is vertical and arranged in parallel, it is inserted into filter chamber (41)
The bottom of the interior air inlet pipeline (42) is lower than the bottom level of outlet pipe (43).
4. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 2,
It is characterized in that, the air inlet pipeline (42) and outlet pipe (43) is arranged horizontally and mutually in parallel, the air inlet pipeline
(42) it is located at the bottom of outlet pipe (43).
5. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 3,
It is characterized in that, the injection port (2), which is equipped with, locally to generate high fuel factor in tissue sample in a short time, make animal
The albuminous degeneration of tissue solidifies, and the volatilization of Volatile Metabolites moment generates smoke the area heating installation of gas or aerosol.
6. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 2,
It is characterized in that, smog gas or gas can further be promoted by being additionally provided on the outside of the air inlet pipeline (42) and outlet pipe (43)
The Quick-gasifying that a small amount of solid small particles or drop are remained in colloidal sol further increases the gas sample amount that can be used for mass spectral analysis
Assisted heating device, the assisted heating device is wrapped on the outer wall of air inlet pipeline (42) and outlet pipe (43).
7. the online portable mass spectrometer of Volatile Metabolites in a kind of tissue sample according to claim 1,
It is characterized in that, the high temperature collision heater strip is located in the sample introduction interface of portable ion trap mass spectrometer (1), the high temperature
Heater strip is made of iron-nickel-chromium, and heating temperature is up to 500 degree or more.
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| CN113781630A (en) * | 2021-08-04 | 2021-12-10 | 上海健康医学院 | Brain tissue deformation correction method based on REIMS, storage medium and terminal equipment |
| CN114324553A (en) * | 2021-12-21 | 2022-04-12 | 上海裕达实业有限公司 | Low residual film sampling device |
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| CN210269709U (en) * | 2019-02-20 | 2020-04-07 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | On-line portable mass spectrometry device for volatile metabolites in tissue sample |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102938362A (en) * | 2011-08-15 | 2013-02-20 | 中国科学院大连化学物理研究所 | Piggy-back portable on-line analysis time-of-flight mass spectrometer |
| CN203367224U (en) * | 2013-06-13 | 2013-12-25 | 无锡华质铂马生物医药技术有限公司 | Normal pressure direct ionization mass spectrum device of concealed ion source |
| CN103531431A (en) * | 2012-07-05 | 2014-01-22 | 中国科学院大连化学物理研究所 | Online mass spectrum sample introduction device with tubular film inside ionization source |
| CN103730325A (en) * | 2013-12-27 | 2014-04-16 | 昆山禾信质谱技术有限公司 | Device and method for on-line rapid analysis of volatile organic compound |
| US20150380229A1 (en) * | 2013-04-19 | 2015-12-31 | Shimadzu Corporation | Mass spectrometer |
| CN206177876U (en) * | 2016-11-17 | 2017-05-17 | 中国科学院大连化学物理研究所 | Real -time on -line measuring pyrolysis product's sampling device |
| CN206660638U (en) * | 2017-03-28 | 2017-11-24 | 山东沾化金嘉利化工科技有限公司 | The evacuation protector of the ethylhexyl of TGA 2 |
| CN108630517A (en) * | 2018-05-10 | 2018-10-09 | 中国科学院大气物理研究所 | The plasma ionization method and device of Atmospheric particulates |
| CN210269709U (en) * | 2019-02-20 | 2020-04-07 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | On-line portable mass spectrometry device for volatile metabolites in tissue sample |
-
2019
- 2019-06-24 CN CN201920950399.8U patent/CN210269709U/en active Active
- 2019-06-24 CN CN201910547492.9A patent/CN110146587A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102938362A (en) * | 2011-08-15 | 2013-02-20 | 中国科学院大连化学物理研究所 | Piggy-back portable on-line analysis time-of-flight mass spectrometer |
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| US20150380229A1 (en) * | 2013-04-19 | 2015-12-31 | Shimadzu Corporation | Mass spectrometer |
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| CN103730325A (en) * | 2013-12-27 | 2014-04-16 | 昆山禾信质谱技术有限公司 | Device and method for on-line rapid analysis of volatile organic compound |
| CN206177876U (en) * | 2016-11-17 | 2017-05-17 | 中国科学院大连化学物理研究所 | Real -time on -line measuring pyrolysis product's sampling device |
| CN206660638U (en) * | 2017-03-28 | 2017-11-24 | 山东沾化金嘉利化工科技有限公司 | The evacuation protector of the ethylhexyl of TGA 2 |
| CN108630517A (en) * | 2018-05-10 | 2018-10-09 | 中国科学院大气物理研究所 | The plasma ionization method and device of Atmospheric particulates |
| CN210269709U (en) * | 2019-02-20 | 2020-04-07 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | On-line portable mass spectrometry device for volatile metabolites in tissue sample |
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| CN113781630A (en) * | 2021-08-04 | 2021-12-10 | 上海健康医学院 | Brain tissue deformation correction method based on REIMS, storage medium and terminal equipment |
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