CN110132969A - A kind of portable pathology slide scanner and system - Google Patents
A kind of portable pathology slide scanner and system Download PDFInfo
- Publication number
- CN110132969A CN110132969A CN201910452942.6A CN201910452942A CN110132969A CN 110132969 A CN110132969 A CN 110132969A CN 201910452942 A CN201910452942 A CN 201910452942A CN 110132969 A CN110132969 A CN 110132969A
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- China
- Prior art keywords
- slide
- acquisition device
- image acquisition
- light source
- pedestal
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
Abstract
The present invention provides a kind of portable slide scanner, belongs to Biomedical Instruments technical field.Including pedestal, image acquisition device bracket, two-dimension translational platform, light source, slide clamper, non-spherical lens and controller；The upper ends image acquisition device bracket of pedestal, image acquisition device bracket is for installing image acquisition device；The inside of pedestal and the lower section for being in image acquisition device bracket are equipped with two-dimension translational platform, and for carrying slide clamper, non-spherical lens is composed of two-dimension translational platform multi-disc non-spherical lens, are amplified using non-spherical lens to slide, camera is again imaged it；Light source is installed below slide clamper；Controller connects light source and image acquisition device.The present invention also provides the systems including the scanner.The present invention can not only provide the micro-image of equal quality, and volume is smaller with weight, and power consumption is lower, portability, particularly suitable for scenes such as a line clinical department, the medical region of interim or movement or burst the condition of a disaster regions.
Description
Technical field
The present invention relates to Biomedical Instruments technical fields, and in particular to a kind of portable pathology slide scanner and is
System.
Background technique
Pathological examination has irreplaceable status in the screening and treatment of tumour and cancer, in recent years clinically
The disease incidence of cancer and tumour is higher, and the demand of pathologic finding also rises with it.Pathologic finding be for check biological organs,
The Pathomorphology method of pathological change in tissue or cell.In order to inquire into the disease mistake that organ, tissue or cell are occurred
Journey, the method that can take certain Pathomorphology inspection check the lesion that they are occurred, and inquire into lesion Producing reason, hair
The occurrence and development process of Anttdisease Mechanism, lesion, finally makes pathological diagnosis.The inspection method of Pathomorphology, it usually needs cut
A certain size pathological tissues, are made pathology slide with pathology method, further look at lesion situation with microscope.Pathology inspection
It looks into and has been widely used in clinical position and scientific research.Such as in surgery Pathology inspection, pathology slide can be defined
Diagnosis and verifying preoperative diagnosis, improve clinical diagnosis level, while can determine that the therapeutic scheme of next step and estimation are pre-
Afterwards, and then clinical levels are improved.No matter pathological examination all has important meaning in clinical medicine or medical research
Justice.
Traditional pathologic finding depends critically upon the experience and industry of single doctor using optical microscopy human eye microscopy
Business is horizontal, there are certain probability of false detection, not only detection efficiency underground, but also the preservation of tissue sample and carry also extremely not
Become, very big obstacle has been manufactured to pathological teaching and remote medical consultation with specialists.Simultaneously as the demands such as further consultation, teaching, hospital's needs pair
Slide carries out the preservation of several years or even many decades.And with the increase of slide quantity, the preservation management cost of slide is also increasingly
It is high.Moreover, certain dyestuffs or marker can generate variation with the time, it is difficult to realize prolonged save.
In recent years, the appearance of pathological scanner solves these problems to a certain extent.Pathological scanner is by pathology glass
Piece digitlization is saved in local storage and cloud memory, and medical personnel directly can carry out disease by digitized image
Manage the reading diagnosis of slide.It is shared that transmission is carried out by internet, is for example projected using mobile display terminal is modernized, it can be with
The efficient and convenient development Telepathology consultation of doctors and pathological teaching.Digitized pathological data not only reduce the preservation of slide at
Originally the efficiency of data sharing is improved, and provides data basis to further realize computer intelligence diagnosis.
The Chinese patent of document CN201610746297 discloses a kind of based on ordinary optical microscope and smart phone
Smart phone, computer and microscopical function are integrated together by Tissue slides scanning means, first with microscope at
Picture recycles smart phone to microscope imaging secondary imaging, finally sends obtained imaging results to computer.Although in fact
The electronization of slide is showed, but it is similar with current traditional pathological scanner device, is all based on traditional microoptic imaging
Device development, the device used is identical as conventional manual microscope, this allows for the pathology slide scanner of automation
Bulky, power consumption is higher, it is necessary to provide dedicated place and be used cooperatively, be unfavorable for testing instruments into a line clinical department.
In addition to this, structure is complicated for traditional pathological scanner device, and transportation cost is high, and instrument assembly is remote having inconvenient traffic using complexity
Area or burst the condition of a disaster region are difficult to use.These all limit pathological scanner in a line clinical department, interim or movement
The application in medical region or the condition of a disaster region that happens suddenly.
Summary of the invention
The present invention provides a kind of portable pathological scanners, compare existing pathology slide scanner, can not only provide
The micro-image of equal quality, and volume is smaller with weight, and power consumption is lower, portability, particularly suitable for line clinic
The scenes such as department, the medical region of interim or movement or burst the condition of a disaster region.
A kind of portable slide scanner, including pedestal further include image acquisition device bracket, two-dimension translational platform, light source, glass
Piece clamper, non-spherical lens and controller；
The upper ends image acquisition device bracket of pedestal, image acquisition device bracket is for installing image acquisition device；Image is adopted
The bottom opening of storage bracket, the camera and apertures in alignment of image acquisition device when work；It is simultaneously adopted in image the inside of pedestal
The lower section of storage bracket is equipped with two-dimension translational platform, and two-dimension translational platform can drive carrying slide clamping for carrying slide clamper
The movement of device planar both direction；Non-spherical lens is composed of multi-disc non-spherical lens, it is pasted on figure when work
As collector camera at, slide is amplified using non-spherical lens, camera is again imaged it；Light source is installed on glass slide clamp
Below holder, for providing illumination for imaging；Controller connects light source and image acquisition device, for acquiring the location information of slide
And it sends image acquisition device to, also send work order to light source and sends synchronous exposure signal to image acquisition device.
Further, described image collector bracket includes bottom plate and the fixed edge positioned at bottom plate two sides, image acquisition device
It is placed on bottom plate, and is limited by two fixed edges；Aperture at bottom plate one, the camera of image acquisition device and aperture pair when work
Together；Two fixed edges use screw thread adjustable structure.
Further, the two-dimension translational platform include the first, second stepping lead screw motor, the first, second guide rail, first,
Second translation stage pedestal；Wherein, the first guide rail is fixed on the first translation stage pedestal, for constraining the first translation stage pedestal one
Dimension is translated on direction；First stepping lead screw motor is connect with the first translation stage pedestal, when the first stepping lead screw motor rotates
When drive the first translation stage pedestal to generate one-dimensional translation；Second guide rail is fixed on slide clamper, for constraining slide clamping
Device is translated in another one-dimensional square；Second stepping lead screw motor is connect with slide clamper, when second stepper motor rotates
When drive slide clamper to generate one-dimensional translation；The lower section fluting of slide clamper is pacified as light source on the second translation stage pedestal
Fill area.
Further, the compound lens field angle is greater than 62 °, and for F-number less than 2.4, equivalent focal length is less than 5.3mm.
Further, the light source uses LED light guide plate or LED lamp bead.
Further, further include image acquisition device, described image collector using smart phone, IPad, tablet computer or
Any one in camera.
A kind of portable slide scanning system, including the scanner and data processing system, data processing system
For splicing to the image of acquisition.
In general, a kind of portable pathological scanner provided by the invention, is detached from traditional microcobjective, and camera shooting is filled
It sets and is combined with aspherical compound lens, it is Polaroid to pathology slide progress, realize the digitlization of slide.Compared to existing pathology glass
Piece scanner, which can not only provide the micro-image of equal quality, and volume and weight are smaller, power consumption
It is lower, it is easier to realize the portability design of instrument.And portable design is more able to satisfy the low land occupation of high performance-price ratio of clinical department
The use demand of area meets burst scene temporary emergency use demand, and provides efficient and convenient shifting for internet medical treatment
Dynamic formula data collection station.
Detailed description of the invention
Fig. 1 is the sweeping scheme schematic diagram using the portable slide scanner of the present invention；
Fig. 2 is the image acquisition device rack assumption diagram of the embodiment of the present invention；
Fig. 3 is two-dimension translational of embodiment of the present invention platform structure chart；
Fig. 4 is the micro-imaging index path that non-spherical lens of the present invention and camera are constituted；
Fig. 5 is workflow schematic diagram of the present invention；
Fig. 6 is controller connection schematic diagram of the present invention；
Icon: image acquisition device 10；Portable slide scanner 20；Pathology slide sample 30；Pedestal 201；Image Acquisition
Device bracket 202；Two-dimension translational platform 203；Light source 204, slide clamper 205, aspherical compound lens 206；First, second stepping
Lead screw motor 2031,2032；First, second translation stage pedestal 2035,2036；Light source installing zone 2037；Mobile phone camera 101；
Lens 1011；Digital image sensor 1012.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.As long as in addition, technical characteristic involved in the various embodiments of the present invention described below
Not constituting a conflict with each other can be combined with each other.
This preferred embodiment provides a kind of portable pathology slide digital scanning imaging scheme.The structure of entire scheme
As shown in Figure 1, including image acquisition device 10, portable slide scanner 20 and pathology slide sample 30.
Fig. 2 and 3 are referred to, portable slide scanner 20 includes pedestal 201, image acquisition device bracket 202, two-dimension translational
Platform 203, light source 204, slide clamper 205, non-spherical lens 206 and controller (not provided in figure).It puts on the top of pedestal 201
Image acquisition device bracket 202 is set, image acquisition device bracket 202 is for installing image acquisition device 10.Image acquisition device bracket 202
Bottom opening 207, the camera of image acquisition device 10 is located at tapping when work.In the pedestal of image acquisition device bracket 202
Portion is equipped with two-dimension translational platform 203, and two-dimension translational platform 203 can drive carrying slide clamper for carrying slide clamper 205
The movement of 205 planar both directions.Non-spherical lens 206 is pasted at the camera of image acquisition device 10, utilizes lens
Slide is amplified, camera is again imaged it.Light source 204 is installed on 206 lower section of slide clamper, provides sufficient intensity for imaging
Illumination.Controller connects light source 204 and image acquisition device 10, for acquiring the location information of slide and sending Image Acquisition to
Device 10 also sends work order to light source 204 and sends synchronous exposure signal to image acquisition device 10.
As shown in Fig. 2, image acquisition device bracket 202 includes the fixed edge of bottom plate and bottom plate two sides, image acquisition device is placed
It is limited on bottom plate, and by two fixed edges.Aperture at bottom plate one, the camera of image acquisition device 10 is located at aperture when work
Place.Two fixed edges use screw thread adjustable structure, to be adapted to the image acquisition device of different outer dimensions, and guarantee mobile phone camera lens
Coaxial state is kept with aspherical compound lens mounting hole 207.
As shown in figure 3, two-dimension translational platform 203 include the first, second stepping lead screw motor 2031 and 2032, first, second
Stainless steel guide rail 2033 and 2034, the first, second translation stage pedestal 2035 and 2036；Wherein, the first guide rail 2033 is right with it
Another guide rail answered is fixed on the first translation stage pedestal 2035, and guide rail is made of stainless steel bar polishing, for constraining translation
Platform is translated in one-dimensional direction.First stepping lead screw motor 2031 is connected through a screw thread with the first translation stage pedestal 2035,
When the rotation of the first stepping lead screw motor 2031, the first translation stage pedestal 2035 generates one-dimensional translation.Similar, the second guide rail
A 2034 corresponding other guide rails are fixed on the second translation stage pedestal 2036, and guide rail is made of stainless steel bar polishing,
It is translated in one-dimensional direction for constraining translation stage.Second stepping lead screw motor 2032 passes through spiral shell with slide clamper 205
Line connection, when stepper motor 2032 rotates, slide clamper 205 generates one-dimensional translation.Two-dimension translational platform shown in Fig. 3 generates
Effect be drive slide specimen according to fixed coordinates position carry out two-dimension translational.Slide clamps on second translation stage pedestal 2036
The lower section fluting of device 205 is used as light source installing zone 2037.By the way of lead screw motor driving, structure is simple, and volume will not be too
Greatly, more compact.
Non-spherical lens 206 is composed of multi-disc aspherical mirror, amplifies imaging for the image to pathology slide.
The compound lens one end design have annular tacky on two sides for be fixed to mobile phone camera.In the preferred embodiment, aspheric
The aspherical mirror that face lens 206 are at least 4 or more is composed, and by the combination of multi-disc lens, rectifiable aberration is realized
High-resolution micro-imaging.The preferred compound lens field angle is greater than 62 ° in this example, and for F-number less than 2.4, equivalent focal length is small
In 5.3mm, effect is best.
The preferred smart phone of image acquisition device 10, it is contemplated that generally hold smart phone per capita, and be carried on whenever and wherever possible
Body, it is convenient to be imaged and consult at any time imaging results.Certainly, be not limited to smart phone, if with camera, memory it is small
Type image acquisition device.Fig. 4 show the portable slide scanner micro-imaging light channel structure figure of slide.Including cell-phone camera
First 101, non-spherical lens 206, lighting source 204, slide specimen 30.It wherein include a piece of lens in mobile phone camera
1011, digital image sensor 1012.Mobile phone built-in lens 1011 are infinity imaging len, for by the image of unlimited distance
It is imaged on imaging sensor 1012, micro-imaging can not be carried out to slide specimen.In order to realize micro-imaging, the present invention passes through
Additional a piece of aspherical compound lens 206 amplifies slide specimen, then passes through the picture of 1011 pairs of mobile phone Built-in lens amplifications again
It carries out Polaroid, the amplification of slide specimen is imaged to constitute micro-imaging optical path and realize.
As shown in fig. 6, controller connection light source (204) and image acquisition device (10), for acquiring the location information of slide
And it sends image acquisition device (10) to, also send work order to light source (204) and sends synchronization to image acquisition device (10)
Exposure signal.Slide clamper 205 preferably uses chute-type structure, and notch is single-pass, size and slide width and thickness
Match, slide specimen can be inserted into from notch and slide into and is fixed in clamper.
The light source that light source 204 can be illuminated using LED light guide plate or LED lamp bead as transmission-type.
The present invention also provides a kind of portable pathology slide digital scanning imaging systems, including slide digital scanning
Instrument and image processing system.The structure of digital scanner is as it was noted above, image processing system can be loaded in the form of APP
On mobile phone or ipad or computer.Described image processing system can pass through wireless communication signal in conjunction with the displacement of two-dimension translational platform
Control mobile phone to slide carry out traversal bat figure, while the image that can be will acquire through row handle, according to the coordinate information of image with
And redundancy carries out image mosaic.The software has the function of magnification calibration, can be accurate by standard slide specimen
Measure the enlargement ratio of micro-imaging.Further, described image processing system can be by picture mosaic result in local handset screen
Upper storage display, is either sent to cloud storage by wirelessly such as wifi, 4G, 5G network or display terminal is shown.
The working principle of the invention and process are briefly described below with reference to Fig. 2 and embodiment:
The portable slide scanner that the present embodiment is proposed is a microscopic imaging device based on mobile phone camera, should
Device is combined in corresponding pair of coordinate points using mobile phone camera using translation stage and controller combination lighting source
Non-spherical lens constitute micro imaging system slide is repeatedly imaged, then utilize mobile phone on processor will repeatedly at
The local picture of picture carries out the micro-image that splicing reconstructs entire slide.
For the present embodiment by taking millet note2 mobile phone as an example, aspherical compound lens is directed at the camera shooting on mobile phone by staff
Head mirror head is adhesively fixed, and guarantees that aspherical mirror is coaxial with mobile lens.Aspherical compound lens outstanding on mobile phone is put into figure
As in the hole on collector bracket.
Image acquisition device bracket is adjusted, mobile phone is fixed.
Handset image processing system is opened, standard slide specimen is put into the slide clamper of pathological scanner, is clicked
Calibration knob.Image processing system, to shooting preservation is carried out, passes through the analysis to line to image to 100 μm on standard slide of line
Image processing system can quickly obtain the sample rate of the machine micro-imaging.Such as line is 67 to occupied pixel quantity, then schemes
The sample rate of picture is 1.5 μm/pixel
Pathology slide is put into the slide clamper of pathological scanner, under the drive of two-dimension translational platform, on clamper
Slide generate relative displacement relative to aspherical compound camera lens, displacement path journey is snakelike, using slide long side as X-direction, short side
For Y-direction.XY both direction traverses slide by step-type movement.The moving step length of X-direction and Y-direction is respectively
The 3/4 of corresponding visual field size, to guarantee the redundancy between image.
With orderly mobile according to fixed coordinates of two-dimension translational platform, mobile phone also according to coordinate auto-focusing and records simultaneously
The slide image of lower corresponding position, after the scanning imagery for completing entire slide, cell phone processor is by image according to coordinate
Information carry out de-redundancy splicing ultimately form entire slide complete digital image it is locally stored or be sent to cloud progress
It is shared.
Staff can check image by mobile phone local, can also be launched data to aobvious by wireless telecommunications
It is shown in display screen.
As it will be easily appreciated by one skilled in the art that the foregoing is merely illustrative of the preferred embodiments of the present invention, not to
The limitation present invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should all include
Within protection scope of the present invention.
Claims (7)
1. a kind of portable slide scanner, including pedestal (201), which is characterized in that further include image acquisition device bracket
(202), two-dimension translational platform (203), light source (204), slide clamper (205), non-spherical lens (206) and controller；
The upper ends image acquisition device bracket (202) of pedestal (201), image acquisition device bracket (202) are adopted for installing image
Storage (10)；The bottom opening (207) of image acquisition device bracket (202), when work the camera of image acquisition device (10) with open
Hole alignment；The inside of pedestal (201) is simultaneously in the lower section of image acquisition device bracket (202) equipped with two-dimension translational platform (203), two dimension
Translation stage (203) can drive carrying slide clamper (205) planar both direction for carrying slide clamper (205)
Movement；Non-spherical lens (206) is composed of multi-disc non-spherical lens, it is pasted on image acquisition device (10) when work
At camera, slide is amplified using non-spherical lens (206), camera is again imaged it；Light source (204) is installed on glass slide clamp
Below holder (206), for providing illumination for imaging；Controller connects light source (204) and image acquisition device (10), for acquiring
The location information of slide simultaneously sends image acquisition device (10) to, also sends work order to light source (204) and to Image Acquisition
Device (10) sends synchronous exposure signal.
2. portable slide scanner according to claim 1, which is characterized in that described image collector bracket (202)
Fixed edge including bottom plate and positioned at bottom plate two sides, image acquisition device (10) are placed on bottom plate, and are limited by two fixed edges；
Aperture at bottom plate one, the camera and apertures in alignment of image acquisition device (10) when work；Two fixed edges use screw thread adjustable structure.
3. portable slide scanner according to claim 1 or 2, which is characterized in that two-dimension translational platform (203) packet
It includes the first, second stepping lead screw motor (2031,2032), the first, second guide rail (2033,2034), the first, second translation stage bottom
Seat (2035,2036)；Wherein, the first guide rail (2033) is fixed on the first translation stage pedestal (2035), flat for constraining first
Moving stage pedestal (2035) is translated in one-dimensional direction；First stepping lead screw motor (2031) and the first translation stage pedestal
(2035) it connects, drives the first translation stage pedestal (2035) to generate when the rotation of the first stepping lead screw motor (2031) one-dimensional flat
It moves；Second guide rail (2034) is fixed on slide clamper (205), for constraining slide clamper (205) in another one-dimensional square
On translated；Second stepping lead screw motor (2032) is connect with slide clamper (205), when second stepper motor (2032) turn
Slide clamper (205) are driven to generate one-dimensional translation when dynamic；The slide clamper (205) on the second translation stage pedestal (2036)
Lower section fluting is used as light source installing zone (2037).
4. portable slide scanner according to claim 1 or 2 or 3, which is characterized in that the compound lens field angle
Greater than 62 °, for F-number less than 2.4, equivalent focal length is less than 5.3mm.
5. portable slide scanner according to claim 1 or 2 or 3, which is characterized in that the light source (204) uses
LED light guide plate or LED lamp bead.
6. portable slide scanner according to claim 1 or 2 or 3, which is characterized in that further include image acquisition device
(10), described image collector (10) is using any one in smart phone, IPad, tablet computer or camera.
7. a kind of portable slide scanning system, which is characterized in that including scanner described in claim 1-5 any one with
And data processing system, data processing system is for splicing the image of acquisition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910452942.6A CN110132969A (en) | 2019-05-28 | 2019-05-28 | A kind of portable pathology slide scanner and system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910452942.6A CN110132969A (en) | 2019-05-28 | 2019-05-28 | A kind of portable pathology slide scanner and system |
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| CN110132969A true CN110132969A (en) | 2019-08-16 |
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| CN201910452942.6A Pending CN110132969A (en) | 2019-05-28 | 2019-05-28 | A kind of portable pathology slide scanner and system |
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| CN111855578A (en) * | 2020-08-14 | 2020-10-30 | 杭州医派智能科技有限公司 | Pathological section scanner |
| CN111912351A (en) * | 2020-07-08 | 2020-11-10 | 任明康 | Scanner |
| CN112051665A (en) * | 2019-09-29 | 2020-12-08 | 上海睿钰生物科技有限公司 | Portable cell analysis system and microscopic imaging method thereof |
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