CN110122500B - Use of betaine zwitterionic surfactants to stabilize peroxide sources - Google Patents

Use of betaine zwitterionic surfactants to stabilize peroxide sources Download PDF

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CN110122500B
CN110122500B CN201910433847.1A CN201910433847A CN110122500B CN 110122500 B CN110122500 B CN 110122500B CN 201910433847 A CN201910433847 A CN 201910433847A CN 110122500 B CN110122500 B CN 110122500B
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peroxide
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betaine
products
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张磊
陆可望
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Kunming Yeshui Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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Abstract

The use of betaine type zwitterionic surfactant to stabilize peroxide source belongs to the field of chemistry. The peroxide source is carbamide peroxide, calcium peroxide, percarbonate, perborate, hydrogen peroxide or polyvinylpyrrolidone hydrogen peroxide complex. The betaine zwitterionic surfactant may be cocamidopropyl dimethylamine caprolactone. Can be used to stabilize peroxide sources in water, methanol, ethanol, propylene glycol, glycerol, sorbitol, propylene glycol, polyacrylic acid. Can be used for water-containing or water-free liquid, paste and colloid. Can be used for preparing toothpaste containing peroxide source and added with sweetener, essence, thickener, filler, and humectant. The invention uses the betaine type zwitterionic surfactant in the preparation of industrial products such as disinfection products, daily chemical products, medical products and the like containing peroxide sources, is particularly suitable for preparing toothpaste, mouthwash and disinfectors containing the peroxide sources, and has very positive significance.

Description

Use of betaine zwitterionic surfactants to stabilize peroxide sources
Technical Field
The invention belongs to the field of chemistry, and particularly relates to an application of a betaine type zwitterionic surfactant in stabilizing a peroxide source. The invention can be applied to industrial products such as disinfection products, daily chemical products, medical products and the like which need to stabilize a peroxide source.
Background
Peroxide refers to a compound containing a peroxy-O-O-. It is characterized in that the molecule contains peroxide ions. After the hydrogen peroxide is dissolved in water, the oxygen element of the hydrogen peroxide is in a high valence state, the hydrogen peroxide can generate oxidation reduction by itself, one oxygen is changed into-2 valence, one oxygen is changed into 0 valence, namely oxygen atom, also called nascent oxygen, the oxygen atom is unstable, and electrons of bacteria can be deprived to be changed into stable-2 valence oxygen ions, so that the sterilization effect is achieved. The process of generating nascent oxygen can be understood as H2O2Activated process, H2O2Under normal conditions, the water and the oxygen are only slowly decomposed into water and oxygen, the decomposition speed is extremely slow, but a plurality of substances can accelerate the decomposition speed, thereby generating the nascent oxygen. Organic matter, high pH value, metal ion, short wave ray, etc. can accelerate the decomposition. This makes it difficult to formulate such substances for use as a single preparation.
The coloring and yellowing of teeth are caused by many reasons, and generally, the reasons are divided into endogenous and exogenous reasons: 1. the exogenous staining is caused by the existence of various bacteria on the tooth surface, which secrete a plurality of sticky substances on the tooth surface, and tea dirt, smoke stain in daily diet, certain mineral substances in drinking water and mineral substances in human saliva are adsorbed on the sticky substances to form bacterial plaque and dental calculus, so that the tooth surface is gradually yellowed or blacked. 2. Endogenous staining is formed during tooth development, e.g., tetracycline is deposited in dentin, which causes the tooth to turn yellow, brown or dark gray, called tetracycline teeth; if drinking water contains too much fluorine, dental fluorosis can be caused, and tooth surfaces are in a chalk color and dark brown patches; hemoglobin can also blacken teeth if bound to bacterial breakdown products after tooth nerve death.
Because the preparation containing the peroxide source is extremely unstable, especially in toothpaste, the essence, metal ions, foaming agent and sweetener contained in the toothpaste can activate the peroxide source to generate nascent oxygen, so that no whitening toothpaste containing the peroxide source exists so far.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the application of a betaine type zwitterionic surfactant in stabilizing a peroxide source.
The invention relates to the use of betaine zwitterionic surfactants to stabilize peroxide sources, said peroxide sources being urea peroxide, or calcium peroxide, or percarbonate, or perborate, or hydrogen peroxide, or polyvinylpyrrolidone hydrogen peroxide complexes.
The betaine zwitterionic surfactant of the present invention may be cocamidopropyl dimethylamine caprolactone.
The application of the betaine type amphoteric surfactant in stabilizing the peroxide source can stabilize the peroxide source in water, methanol, ethanol, propylene glycol, glycerol, sorbitol, allyl alcohol and polyacrylic acid.
The betaine type amphoteric surfactant can be used for stabilizing peroxide sources, and can be used for water-containing or water-free liquids, pastes and colloids.
The betaine type zwitterionic surfactant disclosed by the invention has the application of stabilizing a peroxide source, and can be used for preparing toothpaste containing the peroxide source, wherein the toothpaste is added with a sweetening agent, essence, a thickening agent, a filler and a humectant.
In conclusion, the invention uses the betaine type zwitterionic surfactant in preparing industrial products such as disinfection products, daily chemical products, medical products and the like containing peroxide sources, and is particularly suitable for preparing toothpaste, mouthwash and disinfectors containing the peroxide sources.
Stability test on peroxide Source
1. Principal material
20mL brown sample bottle
Cocoamidopropyl dimethylamine ethylene lactone, anhydrous betaine, vitamin C and carbamide peroxide
Ultraviolet visible light luminous photometer
2. Sample preparation with Water as solvent
Negative control: taking 600mL of deionized water as a solvent, adding 0.001% of food-grade water-soluble blue pigment (E133),
after stirring well, 20mL of the solution was taken and placed in a brown glass bottle with a cap.
Blank comparison: the solution is used for measuring the absorbance by an ultraviolet visible light spectrophotometer and is prepared for use. 450mL of deionized water was taken as the solvent, urea peroxide was added to make the solution contain 1.0% H2O2Then averagely dividing into 9 parts, each 50mL, respectively adding cocamidopropyl dimethylamine ethyl lactone, anhydrous betaine and vitamin C into the 9 parts of solution, so that the three parts of solution contain 0.1 percent of cocamidopropyl dimethylamine ethyl lactone respectively,
1.0 percent and 3.0 percent; the other three solutions respectively contain 0.1%, 1.0% and 3.0% of anhydrous betaine; the final three solutions contain 0.1%, 1.0% and 3.0% of vitamin C respectively.
Positive contrast: 550mL of the prepared negative control solution was taken and carbamide peroxide was added so that the solution contained 1.0% H2O220mL of the solution was taken and contained in a brown glass bottle with a cap.
The test sample: 450mL of prepared positive control is taken, 9 parts of the positive control are divided into 9 parts which are filled into 9 brown glass bottles with covers, each part is 50mL, and cocamidopropyl dimethylamine ethyl lactone, anhydrous betaine and vitamin C are respectively added into the 9 parts of solution, so that the three parts of solution contain 0.1 percent of cocamidopropyl dimethylamine ethyl lactone respectively,
1.0 percent and 3.0 percent; the other three solutions respectively contain 0.1%, 1.0% and 3.0% of anhydrous betaine; the final three solutions contain 0.1%, 1.0% and 3.0% of vitamin C respectively.
3. Sample preparation with propylene glycol as solvent
Prepared according to the method of "2. sample preparation with water as solvent", the solvent water is exchanged for propylene glycol.
4. Test method
Setting a negative control, a positive control and nine test samples, placing all the test bottles at room temperature in a dark place for storage, and detecting the absorbance of the samples by using an ultraviolet visible light spectrophotometer after 7 days and 90 days respectively. The absorbance at 634nm was measured for the sample in water and 630nm for the sample in propylene glycol. If the absorbance is reduced, the carbamide peroxide in the solution is activated and decomposed, and when the carbamide peroxide is activated, the generated active oxygen generates oxidation reaction to destroy the chromophoric group in the pigment, so that the fading is generated, and the transmittance of the solution to light at the wavelength is increased, the absorbance is reduced, and the system is not stable.
5. Test results
TABLE 1 stability test with water as solvent
Figure BDA0002069889670000031
TABLE 2 stability test with propylene glycol as solvent
Figure BDA0002069889670000032
6. Conclusion of the experiment
Cocamidopropyl dimethylamine ethylene lactone has a better stabilizing effect on carbamide peroxide in water and propylene glycol, compared with the excellent degree of the stability of three selected substances on carbamide peroxide: cocamidopropyl dimethylamine, caprolactone > vitamin C > betaine anhydrous, and urea peroxide was also found to be more stable in propylene glycol than in water.
Second, stability test in toothpaste
1. Sample preparation
Three test samples were prepared according to the formulation of table 3: test sample 1, test sample 2, and test sample 3.
Table 3 raw material weight percent (%)
Figure BDA0002069889670000041
Putting all toothpaste samples used for testing into a sealed transparent glass bottle, and placing in a dark place at room temperature, wherein the index of hydrogen peroxide decomposition is obtained when the color becomes light or disappears and bubbles are generated. If discoloration or bubble formation occurs, it is evident that the peroxide source in the toothpaste is activated and decomposed, and the system is unstable.
2. Test results
After standing for 6 months, the three test samples were observed to have no color change or no bubble generation, indicating that test sample 1, test sample 2, and test sample 3 of the present invention were stable.
The invention has the beneficial effects that:
after the peroxide source is dissolved in water, the oxygen element of the hydrogen peroxide is in a high valence state and can generate oxidation reduction by itself, one oxygen is changed into a valence of-2, the other oxygen is changed into a valence of 0,it is an oxygen atom, also known as nascent oxygen. The process of generating nascent oxygen can be understood as H2O2By the process of activation, many substances accelerate H2O2The rate of decomposition, thereby producing nascent oxygen. Organic matter, high pH value, metal ion, short wave ray, etc. can accelerate the decomposition. This makes it difficult to formulate such substances for use as a single preparation. The present inventors have found that betaine-type zwitterionic surfactants, preferably cocamidopropyl dimethylamine ethylene lactone, have a very good stabilizing effect on peroxide sources. Cocamidopropyl dimethylamine lactone is used as a common amphoteric surfactant and is often used as a foaming agent and a cleaning agent, and the invention finds that the cocoamidopropyl dimethylamine lactone can stabilize a peroxide source, has a very positive effect on developing products containing the peroxide source, particularly has two functions of one substance when being applied to toothpaste and mouthwash, and simultaneously has the functions of the foaming agent and the stabilizing agent.
The compound capable of stabilizing the peroxide source can stabilize the peroxide source added into toothpaste and mouthwash, can also stabilize the peroxide source contained in a disinfectant, and has a stabilizing effect on the storage and transportation of liquid, paste and colloid containing the peroxide source.
Detailed Description
The present invention will be further explained with reference to examples, but the present invention is not limited to the following examples. Modifications of the examples and the scope of the formulations, made by others skilled in the art, to other dosage forms or for other uses are within the scope of the invention.
Example 1: the product is toothpaste, and is prepared from the following raw materials in percentage by mass:
polyvinylpyrrolidone: 1.00 to 4.00 percent,
carbamide peroxide (to actually contain H)2O2Meter): 0.50 to 2.00 percent,
fumed silica: 5.00 to 12.00 percent,
water-soluble powdered essence: 0.50 to 2.00 percent,
sodium saccharin: 0.30 to 0.70 percent,
calcium disodium ethylenediamine tetraacetate: 0.05 to 0.20 percent,
cocamidopropyl dimethylamine caprolactone: 1.00 to 3.00 percent,
the balance being propylene glycol.
Example 2: the product is toothpaste, and is prepared from the following raw materials in percentage by mass:
cetyl hydroxyethylcellulose: 0.50 to 2.00 percent,
polyvinylpyrrolidone hydrogen peroxide complex (as H contained in practice)2O2Meter): 0.50 to 2.00 percent,
fumed silica: 5.00 to 12.00 percent,
water-soluble powdered essence: 0.50 to 2.00 percent,
sucralose: 0.30 to 0.70 percent,
ethylenediaminetetraacetic acid tetrasodium salt: 0.05 to 0.20 percent,
cocamidopropyl dimethylamine caprolactone: 1.00 to 3.00 percent,
the balance being propylene glycol.
Example 3: the product is mouthwash, which is prepared from the following raw materials in percentage by mass:
carbamide peroxide (as H actually contained)2O2Meter): 0.10 to 1.00 percent,
sodium fluoride salt: 0.02 to 0.05 percent of,
glycerol: 1.00 to 10.00 percent,
water-soluble powdered essence: 0.50 to 2.00 percent,
sucralose: 0.30 to 0.70 percent,
disodium ethylene diamine tetraacetate: 0.05 to 0.20 percent,
cocamidopropyl dimethylamine caprolactone: 1.00 to 3.00 percent,
the balance being water.
Example 4: the product is a disinfectant, and is prepared from the following raw materials in percentage by mass:
carbamide peroxide (as H actually contained)2O2Meter): 0.10 to 1.00 percent,
double-chain quaternary ammonium salt: 0.10 to 1.00 percent,
disodium ethylene diamine tetraacetate: 0.05 to 0.20 percent,
cocamidopropyl dimethylamine caprolactone: 1.00 to 3.00 percent,
the balance being water.

Claims (1)

1. Use of a betaine zwitterionic surfactant to stabilise a peroxide source in toothpaste and mouthwash containing the peroxide source, characterised in that: the betaine type zwitterionic surfactant is cocamidopropyl dimethylamine ethyl lactone, the peroxide source is a complex of polyvinylpyrrolidone and hydrogen peroxide or carbamide peroxide, and the mass percentage of the cocamidopropyl dimethylamine ethyl lactone to the peroxide source is 1.00-3.00%: 0.50-2.00%, wherein the mass percent of the peroxide source is calculated by the hydrogen peroxide actually contained.
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5052421A (en) * 1988-07-19 1991-10-01 Henkel Corporation Treatment of aluminum with non-chrome cleaner/deoxidizer system followed by conversion coating

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5052421A (en) * 1988-07-19 1991-10-01 Henkel Corporation Treatment of aluminum with non-chrome cleaner/deoxidizer system followed by conversion coating

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