CN110117291A - A kind of synthetic method of cefotaxime acid - Google Patents
A kind of synthetic method of cefotaxime acid Download PDFInfo
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- CN110117291A CN110117291A CN201910550210.0A CN201910550210A CN110117291A CN 110117291 A CN110117291 A CN 110117291A CN 201910550210 A CN201910550210 A CN 201910550210A CN 110117291 A CN110117291 A CN 110117291A
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- acid
- cefotaxime
- water
- methylene chloride
- cefotaxime acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D501/06—Acylation of 7-aminocephalosporanic acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Abstract
The present invention provides a kind of synthetic methods of cefotaxime acid, comprising the following steps: 7-amino-cephalosporanic acid and benzothiazole active ester are added to the in the mixed solvent by being made of water methylene chloride and cosolvent by (a), stir evenly to obtain mixed liquor；(b) purified water is added into mixed liquor obtained by step (a) and triethylamine carries out acylation reaction, the reaction time is 50 ~ 80min, obtains reaction solution；(c) reaction solution is extracted with water, salt acid for adjusting pH is added in extract liquor to 2.5 ~ 3.0, crystallizes, filtering obtains cefotaxime acid after dry.Having water methylene chloride the present invention provides one kind, (moisture content: 0.1 ~ 0.2%) amount of reordering is hydrated the method at cefotaxime acid, using there is water methylene chloride (moisture content: 0.1 ~ 0.2%), the recovery difficult for reducing methylene chloride reaches energy-efficient purpose, while obtaining the cefotaxime acid of high-purity.
Description
Technical field
The invention belongs to pharmaceutical chemistry technical fields, and in particular to a kind of synthetic method of cefotaxime acid.
Background technique
Entitled (6R, 7R) -3- [(acetoxyl group) the methyl] -7- [(2- amino -4- thiazolyl)-of chemistry of cefotaxime acid
(methoxyimino) acetylamino] -8- oxo -5- thia -1- azabicyclo [4.2.0] oct-2-ene -2- formic acid is the third generation
Cephalosporin is cephalosporin for injections-Cefotaxime Sodium primary raw material, suitable for pneumonia caused by sensitive bacterial and other
Lower respiratory tract infection, urinary tract infections, meningitis, septicemia, abdominal cavity infection, pelvic infection skin soft tissue, reproductive tract infection, bone
With the infection of joint etc..
Its synthetic method is mainly AE active ester method at present, and WO9620198 is reported with two (2-[4-morpholinodithio) disulfides
(DM) 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester (MEAM) is reacted to obtain with ainothiazoly loximate, then is condensed to yield cefotaxime acid with 7-ACA, and obtain by-product
2- sulfurio benzo thiazole (M).This report is to be added with stirring triethylamine using acetone as solvent, after completion of the reaction acid adding crystallization system
Cefotaxime acid is obtained, this is the method for current industrialized production cefotaxime acid.
It then has been reported that and is partly improved on the basis of the above, such as: CN101560217 A report is with dichloro
Methane or chloroform are solvent, and end of reaction is directly added into crystallization after acidulant is acidified and cefotaxime acid is made；
CN101550149A report is using 2- methyltetrahydrofuran as solvent, organic base is added, and after reaction, acid adding, which crystallizes, is made head
Spore thiophene oxime acid.CN101613360 A report is to be added with stirring triethylamine using methylene chloride as solvent, use water after completion of the reaction
Reaction solution after extracting condensation, aqueous extract decoloration crystallize obtained cefotaxime acid.
Above using methylene chloride as the method for solvent, preparing cefotaxime acid acylation reaction needs anhydrous methylene chloride, however,
Containing partial moisture in the methylene chloride recycled in practical application, the processing difficulty for recycling methylene chloride is larger, higher cost, because
This, how while ensureing high product purity, develop a kind of preparation method for being more suitable for industrialized production have it is important
Realistic meaning.
Summary of the invention
It is an object of the invention to provide a kind of synthetic methods of cefotaxime acid, to solve existing method methylene chloride
Recovery difficult is big, problem at high cost.
The purpose of the present invention is what is be achieved through the following technical solutions: a kind of synthetic method of cefotaxime acid, including with
Lower step:
(a) 7-amino-cephalosporanic acid and benzothiazole active ester are added to the mixing by being made of water methylene chloride and cosolvent
In solvent, mixed liquor is stirred evenly to obtain；
(b) it being added purified water into mixed liquor obtained by step (a) and triethylamine carries out acylation reaction, the reaction time is 50 ~
80min obtains reaction solution；
(c) reaction solution is extracted with water, salt acid for adjusting pH is added in extract liquor to 2.5 ~ 3.0, crystallizes, filtering obtains after dry
Cefotaxime acid.The synthetic reaction of cefotaxime acid is as shown in Figure 1.
The 7-amino-cephalosporanic acid and the mass ratio of benzothiazole active ester are 1: 1.3, the additional amount of the purified water
It is the 0.5~3% of 7-amino-cephalosporanic acid quality, preferably 2%.
The water content for having water methylene chloride is 0.1 ~ 0.2%.
The cosolvent is alcohols or amides cosolvent, and additional amount is the 20~200% of 7-ACA weight, preferably 100%.
The co-solvent is methanol, ethyl alcohol or isopropanol.Preferred alcohol, isopropanol.
The amides cosolvent is methylformamide, methylacetamide, N,N-dimethylformamide or dimethylacetamide
Amine.It is preferred that N,N-dimethylformamide (DMF), dimethyl acetamide (DMAC).
The technological progress achieved by the present invention and beneficial effect are:
The present invention provides one kind have water methylene chloride (moisture content: 0.1 ~ 0.2%) amount of reordering hydration at cefotaxime acid method,
Using there is water methylene chloride (moisture content: 0.1 ~ 0.2%), to reduce the recovery difficult of methylene chloride, reach energy-efficient purpose, simultaneously
Obtain the cefotaxime acid of high-purity.
The present invention is by shortening the reaction time, raising conversion rate of products, carries out crystallization filtering after HPLC detection fully reacting,
Resulting cefotaxime acid product purity >=98%, product effect phase endoplasm amount are guaranteed, and yield is suitable for carrying out up to 98.5% or more
Industrial application.
Detailed description of the invention
Fig. 1 is the synthetic reaction formula of cefotaxime acid.Wherein, 1 is cefotaxime acid, and 2 be 7-ACA, and 3 be 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester.
Specific embodiment
Embodiment 1
20.0g 7-ACA and 26.0g 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester, which is mixed in 100mL, water methylene chloride (moisture content: 0.17%) and 20mL ethyl alcohol
In the mixed solvent, 4mL purified water and 17mL triethylamine is added, extracts organic phase twice with water respectively after reacting 60min, takes off
Color, with salt acid for adjusting pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 37g, dry cefotaxime acid 33.38
G, through detecting, purity 99.5%, moisture 0.6% is specifically shown in Table 1.
Comparative example 1
By 20.0g 7-ACA and 26.0g 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester be mixed in 100mL anhydrous methylene chloride (moisture content: 0.05%), 20mL it is anhydrous
Ethyl alcohol, 17mL triethylamine mixed solution in, react 180min after extract organic phase twice with water respectively, decolourize, with hydrochloric acid tune
Saving pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 35g, dry 31.34 g of cefotaxime acid, through detecting,
Its purity is 98.1%, and moisture 0.6% is specifically shown in Table 1.
Embodiment 2
20.0g7-ACA and 26.0gAE- active ester, which is mixed in 100mL, water methylene chloride (moisture content: 0.18%) and 20mL ethanol group
At in the mixed solvent, 4mL purified water and 17mL triethylamine is added, extracts organic phase twice with water respectively after reacting 50min, takes off
Color, with salt acid for adjusting pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 37g, dry cefotaxime acid 33.66
G, purity 99.4%, moisture 0.6% are specifically shown in Table 1.
Embodiment 3
20.0g7-ACA and 26.0gAE- active ester, which is mixed in 100mL, water methylene chloride (moisture content: 0.18%) and in 20mLDMF
3mL purified water and 17mL triethylamine is added in the in the mixed solvent of composition, extracts organic phase twice with water respectively after reacting 80min,
Decoloration, with salt acid for adjusting pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 37g, dry cefotaxime acid
33.17 g, purity 99.3%, moisture 0.7% are specifically shown in Table 1.
Embodiment 4
20.0g7-ACA and 26.0gAE- active ester, which is mixed in 100mL, water methylene chloride (moisture content: 0.18%) and 15mLDMA group
At in the mixed solvent, 3mL purified water and 17mL triethylamine is added, extracts organic phase twice with water respectively after reacting 70min, takes off
Color, with salt acid for adjusting pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 37g, dry cefotaxime acid
33.24g, purity 99.0%, moisture 0.7% are specifically shown in Table 1.
Table 1:
Embodiment 5
Industrial applications example:
100Kg7-ACA and 130Kg 2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic,thiobenzothiazole ester is mixed in 500L (moisture content: 0.17%) to be made of with 75LDMA water methylene chloride
In the mixed solvent, 15L purified water and 85L triethylamine is added, extracts organic phase twice with water respectively after reacting 70min, decolourizes,
With salt acid for adjusting pH=2.5~3.0, growing the grain 1h filters to obtain cefotaxime acid wet-milling 186Kg, dry cefotaxime acid
116.5Kg, purity 99.4%, moisture 0.6%.
Claims (6)
1. a kind of synthetic method of cefotaxime acid, which comprises the following steps:
(a) 7-amino-cephalosporanic acid and benzothiazole active ester are added to the mixing by being made of water methylene chloride and cosolvent
In solvent, mixed liquor is stirred evenly to obtain；
(b) it being added purified water into mixed liquor obtained by step (a) and triethylamine carries out acylation reaction, the reaction time is 50 ~
80min obtains reaction solution；
(c) reaction solution is extracted with water, salt acid for adjusting pH is added in extract liquor to 2.5 ~ 3.0, crystallizes, filtering obtains after dry
Cefotaxime acid.
2. the synthetic method of cefotaxime acid according to claim 1, which is characterized in that the 7-amino-cephalosporanic acid with
The mass ratio of benzothiazole active ester is 1: 1.3, the additional amount of the purified water be 7-amino-cephalosporanic acid quality 0.5~
3%。
3. the synthetic method of cefotaxime acid according to claim 1, which is characterized in that described to have water methylene chloride
Water content is 0.1 ~ 0.2%.
4. the synthetic method of cefotaxime acid according to claim 1, which is characterized in that the cosolvent is alcohols or acyl
Amine cosolvent.
5. the synthetic method of cefotaxime acid according to claim 4, which is characterized in that the co-solvent is first
Alcohol, ethyl alcohol or isopropanol.
6. the synthetic method of cefotaxime acid according to claim 4, which is characterized in that the amides cosolvent is first
Base formamide, methylacetamide, N,N-dimethylformamide or dimethyl acetamide.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114409677A (en) * | 2021-12-31 | 2022-04-29 | 艾美科健（中国）生物医药有限公司 | Preparation method of high-purity cefotaxime acid |
| CN116655559A (en) * | 2023-04-19 | 2023-08-29 | 济宁市食品药品检验检测研究院(济宁市药品不良反应监测中心) | Process and device for recovering 2-mercaptobenzothiazole from cefotaxime acid mother liquor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101613360A (en) * | 2009-08-07 | 2009-12-30 | 哈药集团制药总厂 | A kind of preparation method of cefotaxime |
| CN102702230A (en) * | 2012-05-30 | 2012-10-03 | 华北制药河北华民药业有限责任公司 | Method for preparing cefotaxime acid |
| CN105503904A (en) * | 2015-12-30 | 2016-04-20 | 河南康达制药有限公司 | Preparation method for cefotaxime acid |
| CN105646535A (en) * | 2016-01-24 | 2016-06-08 | 哈尔滨合佳制药有限公司 | Synthesis method of cefotaxime sodium |
-
2019
- 2019-06-24 CN CN201910550210.0A patent/CN110117291B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101613360A (en) * | 2009-08-07 | 2009-12-30 | 哈药集团制药总厂 | A kind of preparation method of cefotaxime |
| CN102702230A (en) * | 2012-05-30 | 2012-10-03 | 华北制药河北华民药业有限责任公司 | Method for preparing cefotaxime acid |
| CN105503904A (en) * | 2015-12-30 | 2016-04-20 | 河南康达制药有限公司 | Preparation method for cefotaxime acid |
| CN105646535A (en) * | 2016-01-24 | 2016-06-08 | 哈尔滨合佳制药有限公司 | Synthesis method of cefotaxime sodium |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114409677A (en) * | 2021-12-31 | 2022-04-29 | 艾美科健（中国）生物医药有限公司 | Preparation method of high-purity cefotaxime acid |
| CN114409677B (en) * | 2021-12-31 | 2023-08-25 | 艾美科健（中国）生物医药有限公司 | Preparation method of high-purity cefotaxime acid |
| CN116655559A (en) * | 2023-04-19 | 2023-08-29 | 济宁市食品药品检验检测研究院(济宁市药品不良反应监测中心) | Process and device for recovering 2-mercaptobenzothiazole from cefotaxime acid mother liquor |
| CN116655559B (en) * | 2023-04-19 | 2024-04-09 | 济宁市食品药品检验检测研究院(济宁市药品不良反应监测中心) | Process and device for recovering 2-mercaptobenzothiazole from cefotaxime acid mother liquor |
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| CN110117291B (en) | 2021-03-23 |
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