CN110093119A - A kind of high-barrier medical adhesive and preparation method thereof - Google Patents
A kind of high-barrier medical adhesive and preparation method thereof Download PDFInfo
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- CN110093119A CN110093119A CN201910467143.6A CN201910467143A CN110093119A CN 110093119 A CN110093119 A CN 110093119A CN 201910467143 A CN201910467143 A CN 201910467143A CN 110093119 A CN110093119 A CN 110093119A
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- epoxy resin
- plasticizer
- medical adhesive
- polyvinylidene chloride
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/02—Non-macromolecular additives
- C09J11/04—Non-macromolecular additives inorganic
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
- C09J11/08—Macromolecular additives
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J127/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Adhesives based on derivatives of such polymers
- C09J127/02—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Adhesives based on derivatives of such polymers not modified by chemical after-treatment
- C09J127/04—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Adhesives based on derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C09J127/08—Homopolymers or copolymers of vinylidene chloride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Laminated Bodies (AREA)
Abstract
The invention discloses a kind of high-barrier medical adhesive, are made by following components: polyvinylidene chloride, epoxy resin, carboxymethyl cellulose, sodium lignin sulfonate, graphene, plasticizer, coupling agent, curing agent, stabilizer.By the adhesive applications in coating paper, it can be obviously improved the barrier property of coating paper, be suitable for Key works Drug packing, invention additionally discloses the preparation methods of the high-barrier medical adhesive.
Description
Technical field
The present invention relates to drug packing fields, and in particular to a kind of high-barrier medical adhesive and preparation method thereof.
Background technique
Adhesive is a kind of substance with fine bond properties.By adhesion strength and cohesive force by surface bonding company
The effect of object is connect, of the same race or two or more homogeneity or heterogeneous product (or material) can be linked together, is solidified
There is the organic or inorganic of sufficient intensity a, natural or synthetic substance afterwards, be referred to as adhesive or bonding agent, bonding
Agent is traditionally referred to as glue.
For drug packing field, adhesive is essential raw material in packaging material.Drug packing material choosing
Adhesive safety and sanitation performance will be got well, ought to nontoxic, free from extraneous odour, if directly contact drug also need it is non-corrosive, will not be right
Packaging drug damages.And in order to extend the quality guarantee period of medicament phase, the barrier property of packaging material also there are certain requirements, usually come
It says, packaging material barrier property is higher, and the quality guarantee period of medicament phase then can be longer.Current existing drug packing material, barrier property is bad,
It is unfavorable for the long-term preservation of drug.
Coating paper is a kind of packaging material coated a coating on body paper and paper is made to obtain barrier property.With coating paper generation
For aluminium foil layer, compared to for aluminium foil, coating paper more safety and environmental protection reduces the demand to bauxite resource, reduces packing cost.But
It is that presently, the barrier property of coating paper is poor, far below the barrier property of aluminium foil, is difficult to substitute in drug packing field a period of time
Aluminium-foil paper.
Summary of the invention
In order to solve the above-mentioned technical problem, the present invention discloses a kind of high-barrier medical adhesive, by the adhesive applications in
Coating paper can be obviously improved the barrier property of coating paper, be suitable for Key works Drug packing, invention additionally discloses the high-barrier medical glue
The preparation method of stick.
The present invention is achieved through the following technical solutions:
A kind of high-barrier medical adhesive is made by following components:
Polyvinylidene chloride, epoxy resin, carboxymethyl cellulose, sodium lignin sulfonate, graphene, plasticizer, coupling agent,
Curing agent, stabilizer.
In the present invention, polyvinylidene chloride its intermolecular cohesive force in adhesive is strong, and crystallinity is high, and the chlorine in molecule is former
Son has hydrophobicity, not will form hydrogen bond, and oxygen molecule and hydrone are difficult to move in PVDC molecule, with excellent oxygen barrier and
Hinder moist, plasticizer and stabilizer in composition are used to increase the plasticity of polyvinylidene chloride, and epoxy resin is in coupling agent, solid
Under the action of agent, solidification crosslinking generates reticular structure, effectively increases the mechanical strength after adhesive solidifies, graphene is known
One of highest material of intensity, while also having good toughness, and can be bent, enhancing solidify after adhesive toughness with
Intensity avoids the carboxymethyl cellulose for being deformed, being broken or being layered under external force, in component, sodium lignin sulfonate energy
Enough it is dispersed in graphene uniform in adhesive, avoiding graphene from reuniting influences the mechanical performance after adhesive solidifies, while carboxylic
Containing the largely hydroxyl and aldehyde groups homologous with coating paper in methylcellulose, lignin sulfonic acid sodium molecule, with coating paper
Hydrogen bond can be formed after contact with coating paper surface molecular rapidly, effectively enhance the bonding force between adhesive and coating paper, avoid
Bubble is generated between adhesive and coating paper after by external force, is detached from even layering, is further enhanced obtained compound
The barrier property of film.
Further, a kind of high-barrier medical adhesive is made by the component of following mass fraction:
70-80 parts of polyvinylidene chloride, 9-12 parts of epoxy resin, 6-8 parts of carboxymethyl cellulose, sodium lignin sulfonate 5-7
Part, 6-8 parts of graphene, 6-10 parts of plasticizer, 2-3 parts of coupling agent, 0.6-1.5 parts of curing agent, 4-8 parts of stabilizer.
In the present invention, each component uses above-mentioned quality proportioning, the barrier property to air, vapor of obtained adhesive
Height, and good toughness, be unlikely to deform, be broken or fall off, said components and quality proportioning are that inventor obtains by a large number of experiments
Result.
Preferably, a kind of high-barrier medical adhesive is made by the component of following mass fraction:
75 parts of polyvinylidene chloride, 10 parts of epoxy resin, 7 parts of carboxymethyl cellulose, 6 parts of sodium lignin sulfonate, graphene 7
Part, 8 parts of plasticizer, 2 parts of coupling agent, 1.2 parts of curing agent, 6 parts of stabilizer.
Each component of the present invention is best using the barrier property of adhesive made from above-mentioned quality proportioning, mechanical performance.
Further, the polyvinylidene chloride is polyvinylidene chloride latex, and the plasticizer is dibutyl sebacate
Or epoxy dioleate.
Further, the coupling agent is γ aminopropyltriethoxy silane or α-phenylaminomethyl triethoxysilicane
Alkane, the epoxy resin are one of bisphenol F epoxy resin, cycloaliphatic epoxy resin, polyurethane modified epoxy resin or more
Kind.
Further, the curing agent is latent curing agent, specially ethylenediamine or diethylenetriamine, the stabilizer
For dibutyl tin dilaurate.
In the present invention, graphene oxide replacement is can also be used in graphene.
A kind of preparation method of high-barrier medical adhesive, comprising the following steps:
(1) polyvinylidene chloride latex, epoxy resin, carboxymethyl cellulose, lignin sulfonic acid are weighed according to mass fraction
Sodium, graphene, plasticizer, coupling agent, curing agent, stabilizer are spare；
(2) stabilizer, plasticizer are added in polyvinylidene chloride latex, mixing is stirred at low speed at 40-60 DEG C；
(3) successively epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are added to while stirring
In mixed liquor obtained by step (2), vacuum high-speed stirred 40-60min at 40-60 DEG C；
(4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min.
In the present invention, stabilizer, plasticizer are added in polyvinylidene chloride latex, can effectively improve two chloroethene of segregation
The plasticity of alkene, convenient for mixing, reacting and solidifying with remaining component, vacuum high-speed stirred is conducive to mix between each component at 40-60 DEG C
It is even and be coupled, it is eventually adding curing agent stirring, is coated on coating paper solidification.
A kind of application of high-barrier medical adhesive in Key works Drug packing.
A kind of high-barrier medical composite membrane, by the way that a kind of above-mentioned high-barrier medical adhesive to be coated on coating paper body paper
It is made.
Adhesive of the invention can be used various modes with body paper and be coated with, and such as be coated between two or more layers body paper, can also
The one or both sides of single layer body paper are coated on, coating thickness is decided according to the actual requirements.
The body paper is glazed printing paper or ground wood pulp body paper or Deinking Pulp body paper.
Compared with prior art, the present invention having the following advantages and benefits:
A kind of high-barrier medical adhesive of the present invention, polyvinylidene chloride its intermolecular cohesive force in adhesive is strong, knot
Brilliant degree is high, and the chlorine atom in molecule has hydrophobicity, not will form hydrogen bond, oxygen molecule and hydrone are difficult to move in PVDC molecule
Dynamic, moist with excellent oxygen barrier and resistance, plasticizer and stabilizer in composition are used to increase the modeling of polyvinylidene chloride
Property, for epoxy resin under the action of coupling agent, curing agent, solidification crosslinking generates reticular structure, after effectively increasing adhesive solidification
Mechanical strength, graphene is one of highest material of known strength, while also having good toughness, and can be bent, and is increased
The toughness and intensity of adhesive after strong cured, avoid being deformed, be broken or being layered under external force, the carboxylic first in component
Base cellulose, sodium lignin sulfonate can be such that graphene uniform is dispersed in adhesive, and avoiding graphene from reuniting influences adhesive
Mechanical performance after solidification, while containing largely homologous with coating paper body paper in carboxymethyl cellulose, lignin sulfonic acid sodium molecule
Hydroxyl and aldehyde groups, after being contacted with coating paper body paper can rapidly with body paper surface molecular formed hydrogen bond, effectively enhance
Bonding force between adhesive and body paper is avoided generating bubble between adhesive and coating paper body paper after by external force, is detached from
It is even layered, further enhances the barrier property of composite membrane obtained.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below with reference to embodiment, the present invention is made
Further to be described in detail, exemplary embodiment of the invention and its explanation for explaining only the invention, are not intended as to this
The restriction of invention.
Embodiment 1
A kind of high-barrier medical adhesive of the present invention, is made by following processing step:
1) 70 parts of polyvinylidene chloride latex, 12 parts of epoxy resin, 8 parts of carboxymethyl cellulose, sodium lignin sulfonate 5 are weighed
Part, 6 parts of graphene, 6 parts of plasticizer, 2 parts of coupling agent, 1.5 parts of curing agent, 4 parts of dibutyl tin dilaurate it is spare；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) successively epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are added to while stirring
In mixed liquor obtained by step 2), at 40-60 DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the plasticizer is dibutyl sebacate.
The coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin is bisphenol F epoxy resin.It is described
Curing agent is ethylenediamine.
Embodiment 2
A kind of high-barrier medical adhesive of the present invention, is made by following processing step:
1) 80 parts of polyvinylidene chloride latex, 9 parts of epoxy resin, 6 parts of carboxymethyl cellulose, sodium lignin sulfonate 7 are weighed
Part, 8 parts of graphene, 10 parts of plasticizer, 3 parts of coupling agent, 0.6 part of curing agent, 8 parts of dibutyl tin dilaurate it is spare；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) successively epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are added to while stirring
In mixed liquor obtained by step 2), at 40-60 DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the plasticizer is epoxy dioleate.
The coupling agent is α-phenylaminomethyl triethoxysilane, and the epoxy resin includes bisphenol F epoxy resin 6
Part, 3 parts of cycloaliphatic epoxy resin.The curing agent is diethylenetriamine.
Embodiment 3
A kind of high-barrier medical adhesive of the present invention, is made by following processing step:
1) 75 parts of polyvinylidene chloride latex, 10 parts of epoxy resin, 7 parts of carboxymethyl cellulose, sodium lignin sulfonate 6 are weighed
Part, 7 parts of graphene, 8 parts of plasticizer, 2 parts of coupling agent, 1.2 parts of curing agent, 6 parts of dibutyl tin dilaurate；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) successively epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are added to while stirring
In mixed liquor obtained by step 2), at 40-60 DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the plasticizer is dibutyl sebacate.
The coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin is polyurethane modified epoxy resin.
The curing agent is diethylenetriamine.
The following are comparative examples
Embodiment 4
A kind of high-barrier medical adhesive is made by following processing step:
1) 75 parts of polyvinylidene chloride latex, 10 parts of epoxy resin, 7 parts of graphene, 8 parts of plasticizer, coupling agent 2 are weighed
Part, 1.2 parts of curing agent, 6 parts of dibutyl tin dilaurate；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) successively epoxy resin, graphene, coupling agent are added in mixed liquor obtained by step 2) while stirring, 40-60
At DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the plasticizer is dibutyl sebacate.
The coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin is polyurethane modified epoxy resin.
The curing agent is diethylenetriamine.
The present embodiment and the difference of embodiment 3 are: not including component carboxymethyl cellulose, sodium lignin sulfonate.
Embodiment 5
A kind of high-barrier medical adhesive is made by following processing step:
1) 75 parts of polyvinylidene chloride latex, 10 parts of epoxy resin, 7 parts of carboxymethyl cellulose, sodium lignin sulfonate 6 are weighed
Part, 8 parts of plasticizer, 2 parts of coupling agent, 1.2 parts of curing agent, 6 parts of dibutyl tin dilaurate；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) epoxy resin, carboxymethyl cellulose, sodium lignate, coupling agent are successively added to step 2) institute while stirring
It obtains in mixed liquor, at 40-60 DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
The present embodiment and the difference of embodiment 3 are: not including component graphene.
In the present embodiment, the plasticizer is dibutyl sebacate.
The coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin is polyurethane modified epoxy resin.
The curing agent is diethylenetriamine.
The present embodiment and the difference of embodiment 3 are: not including component graphene.
Embodiment 6
A kind of high-barrier medical adhesive is made by following processing step:
1) 75 parts of polyvinylidene chloride latex, 10 parts of epoxy resin, 7 parts of carboxymethyl cellulose, sodium lignin sulfonate 6 are weighed
Part, 7 parts of graphene, 2 parts of coupling agent, 1.2 parts of curing agent；
2) epoxy resin, carboxymethyl cellulose, lignin acid is successively added into polyvinylidene chloride latex while stirring
Sodium, graphene, coupling agent at 40-60 DEG C, are stirred under vacuum 50min with 2500r/min revolving speed；
3) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin changes for polyurethane
Property epoxy resin.The curing agent is diethylenetriamine.
The present embodiment and the difference of embodiment 3 are: not including component dibutyl tin dilaurate and plasticizer.
Embodiment 7
A kind of high-barrier medical adhesive is made by following processing step:
1) 65 parts of polyvinylidene chloride latex, 15 parts of epoxy resin, 7 parts of carboxymethyl cellulose, sodium lignin sulfonate 8 are weighed
Part, 5 parts of graphene, 8 parts of plasticizer, 3 parts of coupling agent, 1.8 parts of curing agent, 6 parts of dibutyl tin dilaurate；
2) dibutyl tin dilaurate, plasticizer are added in polyvinylidene chloride latex, at 40-60 DEG C, with
1000r/min revolving speed stirs 15min；
3) successively epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are added to while stirring
In mixed liquor obtained by step 2), at 40-60 DEG C, 50min is stirred under vacuum with 2500r/min revolving speed；
4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min with 200r/min revolving speed.
In the present embodiment, the plasticizer is dibutyl sebacate.
The coupling agent is γ aminopropyltriethoxy silane, and the epoxy resin is polyurethane modified epoxy resin.
The curing agent is diethylenetriamine.
The present embodiment is from the difference of embodiment 3: each component quality proportioning is different.
It is respectively used to the embodiment 1-7 adhesive prepared to prepare Key works Drug packing film, the specific method is as follows:
7 groups of coating paper body paper are chosen, every group of body paper 40 is opened, and 7 groups of body paper numbers are 1-7 and embodiment 1-7 system is respectively adopted
Standby adhesive coating.Coating paper body paper combination of two is opened for every group 40 into a packaging film, and two body paper of packaging film overlap, former
Pass through the adhesive bonding of coating between paper.
Every group of packaging film is divided into 5 groups, vapor, nitrogen, carbon dioxide gas, oxygen is carried out respectively and penetrates
Appearance is tested after amount and heat-sealing.Wherein, steam penetrating capacity is surveyed referring to steam penetrating capacity measuring method-YBB00092003
Fixed, nitrogen, carbon dioxide gas, oxygen transit dose are measured referring to gas transit dose measuring method-YBB00082003, heat-sealing experiment
It is tested using puller system, condition is 210 DEG C, 2.0kgf/cm2, continues 15-25min.
Test result is as follows shown in table:
In upper table, vapor, nitrogen, carbon dioxide gas, the oxygen transit dose of each group packaging film are all made of average value.
As seen from the above table, after the adhesive of 1-3 of embodiment of the present invention preparation is coated on body paper, obtained packaging film for
The transit dose of vapor is lower than 0.5g/ (m2·24h)；Nitrogen, carbon dioxide gas, oxygen transit dose are below
0.5cm3/(m2·24h·0.1MPa)；After heat-sealing sterilizing, internal flawless, surfacing, bubble-free in packaging film, not
Appearance is deformed or is layered.
After the adhesive of embodiment 4-7 preparation is coated on coating paper body paper, obtained packaging film is for the saturating of vapor
Excess of greater than 1.3g/ (m2·24h)；1.2cm3/ (m2 is all larger than for nitrogen, carbon dioxide gas, oxygen transit dose
24h·0.1MPa)；After heat-sealing sterilizing, there is fold in surface, has bubble generation, blind crack occurs in inside, and part goes out
Existing lamination.
In conclusion the adhesive barrier property of embodiment 1-3 preparation, heat-sealing experiment are much higher than glue prepared by embodiment 4-7
Stick.
Above-described specific embodiment has carried out further the purpose of the present invention, technical scheme and beneficial effects
It is described in detail, it should be understood that being not intended to limit the present invention the foregoing is merely a specific embodiment of the invention
Protection scope, all within the spirits and principles of the present invention, any modification, equivalent substitution, improvement and etc. done should all include
Within protection scope of the present invention.
Claims (9)
1. a kind of high-barrier medical adhesive, which is characterized in that be made by following components:
Polyvinylidene chloride, epoxy resin, nano aluminium oxide, carboxymethyl cellulose, sodium lignin sulfonate, graphene, plasticizer,
Coupling agent, curing agent, stabilizer.
2. a kind of high-barrier medical adhesive according to claim 1, which is characterized in that pass through the group of following mass fraction
Divide and be made:
70-80 parts of polyvinylidene chloride, 9-12 parts of epoxy resin, 6-8 parts of carboxymethyl cellulose, 5-7 parts of sodium lignin sulfonate, stone
Black alkene 6-8 parts, 6-10 parts of plasticizer, 2-3 parts of coupling agent, 0.6-1.5 parts of curing agent, 4-8 parts of stabilizer.
3. a kind of high-barrier medical adhesive according to claim 1, which is characterized in that pass through the group of following mass fraction
Divide and be made:
75 parts of polyvinylidene chloride, 10 parts of epoxy resin, 7 parts of carboxymethyl cellulose, 6 parts of sodium lignin sulfonate, 7 parts of graphene,
8 parts of plasticizer, 2 parts of coupling agent, 1.2 parts of curing agent, 6 parts of stabilizer.
4. a kind of high-barrier medical adhesive according to claim 1, which is characterized in that the polyvinylidene chloride is inclined
Polyvinyl dichloride latex, the plasticizer are dibutyl sebacate or epoxy dioleate.
5. a kind of high-barrier medical adhesive according to claim 1, which is characterized in that the coupling agent is gamma-amino
Propyl-triethoxysilicane or α-phenylaminomethyl triethoxysilane, the epoxy resin are bisphenol F epoxy resin, alicyclic
One of epoxy resin, polyurethane modified epoxy resin are a variety of.
6. a kind of high-barrier medical adhesive according to claim 1, which is characterized in that the curing agent is solid for latency
Agent, specially ethylenediamine or diethylenetriamine, the stabilizer are dibutyl tin dilaurate.
7. such as a kind of preparation method of high-barrier medical adhesive of any of claims 1-6, which is characterized in that packet
Include following steps:
(1) polyvinylidene chloride latex, epoxy resin, carboxymethyl cellulose, sodium lignin sulfonate, stone are weighed according to mass fraction
Black alkene, plasticizer, coupling agent, curing agent, stabilizer are spare；
(2) stabilizer, plasticizer are added in polyvinylidene chloride latex, stir at low speed mixing；
(3) epoxy resin, carboxymethyl cellulose, sodium lignate, graphene, coupling agent are successively added to step while stirring
(2) in gained mixed liquor, vacuum high-speed stirred 40-60min at 40-60 DEG C；
(4) it is cooled to 30-35 DEG C, curing agent is added, after being stirred under vacuum 20-25min.
8. application of a kind of high-barrier medical adhesive in Key works Drug packing as described in claim 1-6.
9. a kind of high-barrier medical composite membrane, which is characterized in that by by a kind of high-barrier medical glue described in claim 1-6
Stick is coated on coating paper body paper and is made.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05156226A (en) * | 1991-12-03 | 1993-06-22 | Ube Ind Ltd | Structural adhesive composition |
| CN104046312A (en) * | 2014-06-30 | 2014-09-17 | 无锡市崇安区科技创业服务中心 | Flexible plastic composite packaging material adhesive and preparation method thereof |
| CN104327783A (en) * | 2014-11-25 | 2015-02-04 | 三友（天津）高分子技术有限公司 | Anticorrosive sealant for hems in automobile manufacturing |
| CN109161363A (en) * | 2018-09-07 | 2019-01-08 | 刘建林 | High-barrier aqueous adhesive |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5156226B2 (en) * | 2006-12-15 | 2013-03-06 | 日本原子力発電株式会社 | Nozzle unit support structure in furnace bottom, nozzle unit replacement method, and nozzle unit |
-
2019
- 2019-05-31 CN CN201910467143.6A patent/CN110093119B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05156226A (en) * | 1991-12-03 | 1993-06-22 | Ube Ind Ltd | Structural adhesive composition |
| CN104046312A (en) * | 2014-06-30 | 2014-09-17 | 无锡市崇安区科技创业服务中心 | Flexible plastic composite packaging material adhesive and preparation method thereof |
| CN104327783A (en) * | 2014-11-25 | 2015-02-04 | 三友（天津）高分子技术有限公司 | Anticorrosive sealant for hems in automobile manufacturing |
| CN109161363A (en) * | 2018-09-07 | 2019-01-08 | 刘建林 | High-barrier aqueous adhesive |
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| CN110093119B (en) | 2021-08-03 |
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