CN110090673A - The device and method that microfluid is used to operate small objects is generated based on vibrational excitation - Google Patents
The device and method that microfluid is used to operate small objects is generated based on vibrational excitation Download PDFInfo
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- CN110090673A CN110090673A CN201910156469.7A CN201910156469A CN110090673A CN 110090673 A CN110090673 A CN 110090673A CN 201910156469 A CN201910156469 A CN 201910156469A CN 110090673 A CN110090673 A CN 110090673A
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- micro
- small objects
- microfluid
- liquid pipe
- shifting liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
Abstract
The invention discloses the device that microfluid is used to operate small objects is generated based on vibrational excitation, including copper rod, piezoelectric actuator, link block and the micro-shifting liquid pipe in same plane；One end of micro-shifting liquid pipe is tip, and the other end is connecting pin；One end of piezoelectric actuator and one end of copper rod is vertical fixes, the other end of piezoelectric actuator is fixedly connected by the way that link block is vertical with the connecting pin of micro-shifting liquid pipe, and the tip of micro-shifting liquid pipe and small objects are both placed in open liquid environment；In use, making micro-shifting liquid pipe generate the movement of micro fluid dynamcis small objects in liquid environment by inputting resonant sine-wave voltage to piezoelectric actuator when small objects are located at any position in the outer circle circumferential direction setting range of micro- pipette tip；When small objects are located at the outside of micro- pipette tip, micro-shifting liquid pipe is set to generate the movement of micro fluid dynamcis small objects in liquid environment by inputting off-resonance sine voltage to piezoelectric actuator.
Description
Technical field
The present invention relates to micro-nano operating technology fields, and in particular to one kind generates microfluid for grasping based on vibrational excitation
Make the device and method of small objects.
Background technique
With advances in technology, sciemtifec and technical sphere is higher and higher to the required precision of accurate operation.Pair of accurate operation
The scale of elephant is also smaller and smaller to have reached micro/nano level.The other operation of this micro/nano level micro-group dress, biological field it is thin
A series of Disciplinary Frontiers such as born of the same parents' operation all play an important role.The fast development of micro-nano operating technology to operate small
Biological targets even individual cells are possibly realized.Capture, mobile and rotation process are the most basic in micro-nano operating technology
Three kinds of operation formats.
The mode of operation small objects mainly includes contact operation and contactless operation at present.Contact operation is main
It is the micro-nano operation based on direct Mechanical Contact, contact operation is usually using glutinous between end effector and target
The cooperation of attached power, negative pressure and double end effectors is operated, and realizes flexible and efficient and highly repeatable operation.So
And direct Mechanical Contact makes the release of small objects under micro-nano-scale more difficult than under macro-scale.It is contactless
Operation is mainly driven by various energy fields, mainly includes magnetic field, optical tweezer and electric field etc..But utilize electric field, optical tweezer and magnetic field pair
Biology can significantly damage target when being operated.Whether contact operation and contactless operation, the prior art
In most of micro-nano operating method certain damage is inevitably brought to biological targets during operation.
Summary of the invention
In view of this, generating the device that microfluid is used to operate small objects based on vibrational excitation the present invention provides a kind of
And method, the micro fluid dynamcis small objects that can be generated in open liquid environment using vibrational excitation are mobile, reduce to micro-
Small object brings damage.
The technical solution of apparatus of the present invention are as follows: the device that microfluid is used to operate small objects is generated based on vibrational excitation,
Including copper rod, piezoelectric actuator, link block and the micro-shifting liquid pipe in same plane；One end of the micro-shifting liquid pipe is
Tip, the other end are connecting pin；One end of the piezoelectric actuator is vertical with one end of the copper rod to be fixed, the piezoelectricity
The other end of ceramic actuator is fixedly connected by the way that link block is vertical with the connecting pin of the micro-shifting liquid pipe, the micro-shifting liquid pipe
Tip and small objects are both placed in open liquid environment；
By generating the micro-shifting liquid pipe in liquid environment to the piezoelectric actuator input sine wave voltage
Micro fluid dynamcis small objects are mobile.
As a preferred embodiment, the other end of the copper rod is fixed on the micro-manipulating robot with three degree of freedom
On.
The technical solution one of the method for the present invention are as follows:
At any position that small objects are placed in the outer circle circumferential direction setting range of micro- pipette tip simultaneously
It is in small objects in liquid environment, Xiang Suoshu piezoelectric actuator inputs resonance voltage, and the micro-shifting liquid pipe is driven to shake
Dynamic that liquid environment is made to generate microfluid vortex, absolute pressure of the small objects close to a side surface of microfluid vortex centers is less than
The other side forms the pressure for the direction microfluid vortex centers that one is applied in small objects as force trapping, pushes small
Target is moved to microfluid vortex centers, until small objects high-pressure side stress and microfluid are vortexed the reaction to small objects
Power reaches balance；At this point, the current gradient that the micro-shifting liquid pipe circular motion generates microfluid vortex makes small objects in phase
It answers and is rotated in plane according to the direction contrary with the micro-shifting liquid pipe circular motion；
When described device moves integrally, small objects follow the micro-shifting liquid pipe to translate fortune together by microfluid vortex
It is dynamic.
The technical solution two of the method for the present invention are as follows:
Small objects are placed on to the outside of the micro-shifting liquid pipe axial direction upper prong, the input of Xiang Suoshu piezoelectric actuator
Off-resonance voltage, micro-shifting liquid pipe micro-shifting liquid pipe length direction described in the driving lower edge of the piezoelectric actuator do one
Tie up of reciprocating vibration, micro-shifting liquid pipe vibration makes liquid environment generate microfluid vortex, and small objects are in microfluid vortex
The absolute pressure of one side surface of the heart is less than the other side, forms the direction microfluid vortex centers being applied in small objects
Pressure as force trapping, push small objects to be moved to microfluid vortex centers along the micro-shifting liquid pipe is axial, until small
Target high-pressure side stress and microfluid vortex reach balance to the reaction force of small objects；At this point, the micro-shifting liquid pipe vibration
The current gradient for generating microfluid vortex makes small objects in setting plane internal rotation；
When described device moves integrally, small objects follow the micro-shifting liquid pipe to translate fortune together by microfluid vortex
It is dynamic.
The utility model has the advantages that
(1) present invention can be moved using the micro fluid dynamcis small objects that vibrational excitation generates according to direction initialization, be subtracted
It is small to bring damage to small objects, meanwhile, the operating system of this method is simple, at low cost.
(2) present invention can control the rotation speed of small objects by controlling the input voltage of piezoelectric actuator
Or movement speed.
Detailed description of the invention
Fig. 1 is the micro-shifting liquid pipe schematic diagram of piezoelectric actuator driving.
Fig. 2 is that operation small objects capture above micro-shifting liquid pipe or mobile schematic diagram, (a) are top view, (b) is side
View.
The schematic diagram that small objects are rotated around X-axis when Fig. 3 is micro-shifting liquid pipe circular vibration, (a) are main view, (b) are to bow
View.
Fig. 4 be operation small objects micro-shifting liquid pipe it is axially external capture or movement be schematic diagram.
Fig. 5 is the micro-shifting liquid pipe schematic diagram that small objects are rotated around Y-axis when the vibrations are up and down.
Wherein, 1- copper rod, 2- piezoelectric actuator, 3- link block, 4- micro-shifting liquid pipe
Specific embodiment
The present invention will now be described in detail with reference to the accompanying drawings and examples.
Embodiment 1:
Present embodiments provide a kind of device for being used to operate small objects based on vibrational excitation generation microfluid, Neng Gouli
The micro fluid dynamcis small objects generated with vibrational excitation are mobile, reduce and bring damage to small objects.
As shown in Figure 1, the device includes copper rod 1, piezoelectric actuator 2, link block 3 and micro-shifting liquid pipe 4, piezoelectric ceramics
One end of actuator 2 is vertical with one end of copper rod 1 to be fixed, and the other end of copper rod 1 is fixed on the microoperation with three degree of freedom
In robot, the other end of piezoelectric actuator 2 is fixedly connected by the way that attachment device 3 is vertical with micro-shifting liquid pipe 4, by micro-shifting liquid
The tip of pipe 4 is placed in open liquid environment, wherein copper rod 1, piezoelectric actuator 2, attachment device 3 and micro-shifting liquid
Pipe 4 is in X/Y plane, and the length direction for defining micro-shifting liquid pipe 4 is X to the length direction of piezoelectric actuator 2 is Y
To wherein micro-shifting liquid pipe 4 extends to X-axis forward direction, and copper rod 1 extends to X-axis negative sense.By being inputted just to piezoelectric actuator 2
String wave voltage vibrates micro-shifting liquid pipe 4 in liquid environment and generates microfluid vortex；When sine voltage is copper rod 1 and piezoelectricity
When the off-resonance voltage of ceramic actuator 2, piezoelectric actuator 2 carry out it is one-dimensional of reciprocating vibration, drive micro-shifting liquid pipe 4 do it is one-dimensional
It moves back and forth, when sine voltage is the resonance voltage of copper rod 1 and piezoelectric actuator 2, the vibration of piezoelectric actuator 2
It is dynamic to cause 1 forced vibration of copper rod, the resultant motion of 1 forced vibration of copper rod and the one-dimensional reciprocating motion of piezoelectric actuator 2
Driving micro-shifting liquid pipe 4 moves in a circle.
Embodiment 2:
The embodiment uses the device of embodiment 1, as Figure 2-3, operates the method for small objects such as using the device
Under:
Small objects (micro- glass marble or embryonic cell) are placed on to the outer circle circumferential direction setting range at 4 tip of micro-shifting liquid pipe
At interior any position and it is in small objects in liquid environment, to 2 input sine wave resonance voltage of piezoelectric actuator,
For when small objects are located at XZ plane, micro-shifting liquid pipe 4 moves in a circle using X-axis as rotary shaft makes liquid environment generate miniflow
Body vortex, absolute pressure of the small objects close to a side surface of microfluid vortex centers are less than the other side, form an application
The pressure (force trapping) of direction microfluid vortex centers in small objects, pushes small objects to be vortexed along Z axis to microfluid
Center movement, until the microfluid of small objects high-pressure side stress and high-speed motion vortex reaches the reaction force of small objects
Balance, small objects are opened by the microfluid vortex barrier of the high-speed motion close to micro-shifting liquid pipe 4 at this time, at this point, the circle of micro-shifting liquid pipe 4
The current gradient that Zhou Yundong generates microfluid vortex makes small objects in YZ plane according to opposite with 4 circular motion of micro-shifting liquid pipe
Direction around X-axis rotate.
Meanwhile when device translates under the driving of micro-manipulating robot, small objects are followed micro- by microfluid vortex
The translational motion together of pipette 4；Such as when device moves under the driving of micro-manipulating robot to Z axis positive direction, micro-shifting liquid pipe 4
Microfluid is pushed to move to Z axis positive direction, microfluid pushes small objects mobile to Z axis positive direction；When device is in microoperation machine
When moving under the driving of device people to Z axis negative direction, small objects follow micro-shifting liquid pipe mobile to Z axis negative direction by force trapping.
Embodiment 3:
The embodiment uses the device of embodiment 1, as illustrated in figures 4-5, operates the method for small objects such as using the device
Under: small objects (micro- glass marble or embryonic cell) are placed on to the outside at the axial tip of micro-shifting liquid pipe 4, to piezoelectric ceramic actuator
2 input sine wave off-resonance voltage of device, the forced vibration relative weak of copper rod 1, micro-shifting liquid pipe 4 is in piezoelectric actuator 2
Do along Z axis one-dimensional of reciprocating vibration under driving, the vibration of micro-shifting liquid pipe 4 makes liquid environment generate microfluid vortex, and small objects are close
The absolute pressure of one side surface of microfluid vortex centers is less than the other side, and it is micro- to form a direction being applied in small objects
The pressure (force trapping) at fluid vortex center pushes small objects to move along X axis microfluid vortex centers, until small objects
High-pressure side stress and microfluid vortex reach balance to the reaction force of small objects, and small objects are by close to micro-shifting liquid pipe at this time
The microfluid vortex barrier of 4 high-speed motion is opened, and micro-shifting liquid pipe 4, which vibrates the current gradient for generating microfluid vortex, makes small mesh
XZ plane is marked on to rotate around Y-axis.
Meanwhile when device translates under the driving of micro-manipulating robot, small objects are followed micro- by microfluid vortex
The translational motion together of pipette 4；Such as when device moves under the driving of micro-manipulating robot to X-axis positive direction, micro-shifting liquid pipe 4
Microfluid is pushed to move to X-axis positive direction, microfluid pushes small objects mobile to X-axis positive direction；When device is in microoperation machine
When moving under the driving of device people to Z axis negative direction, small objects follow micro-shifting liquid pipe mobile to X-axis negative direction by force trapping.
In conclusion the above is merely preferred embodiments of the present invention, being not intended to limit the scope of the present invention.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (4)
1. generating the device that microfluid is used to operate small objects based on vibrational excitation, which is characterized in that including in same flat
Copper rod (1), piezoelectric actuator (2), link block (3) and micro-shifting liquid pipe (4) in face；One end of the micro-shifting liquid pipe (4)
For tip, the other end is connecting pin；One end of the piezoelectric actuator (2) is vertical with one end of the copper rod (1) to be fixed,
The other end of the piezoelectric actuator (2) passes through link block (3) fixed company vertical with the connecting pin of the micro-shifting liquid pipe (4)
It connects, the tip of the micro-shifting liquid pipe (4) and small objects are both placed in open liquid environment；
By producing the micro-shifting liquid pipe (4) in liquid environment to the piezoelectric actuator (2) input sine wave voltage
Raw micro fluid dynamcis small objects are mobile.
2. generating the device that microfluid is used to operate small objects based on vibrational excitation as described in claim 1, feature exists
In the other end of the copper rod (1) is fixed on the micro-manipulating robot with three degree of freedom.
3. generating the method that microfluid is used to operate small objects based on vibrational excitation, it uses dress as described in claim 1
It sets, it is characterised in that:
At any position small objects being placed in the outer circle circumferential direction setting range at micro-shifting liquid pipe (4) tip and make
Small objects are in liquid environment, and Xiang Suoshu piezoelectric actuator (2) inputs resonance voltage, drive the micro-shifting liquid pipe
(4) vibration makes liquid environment generate microfluid vortex, absolute pressure of the small objects close to a side surface of microfluid vortex centers
It is less than the other side by force, forms the pressure for the direction microfluid vortex centers that one is applied in small objects as force trapping, push away
Dynamic small objects are moved to microfluid vortex centers, until small objects high-pressure side stress and microfluid are vortexed to small objects
Reaction force reaches balance；At this point, micro-shifting liquid pipe (4) circular motion make microfluid vortex generate current gradient make it is small
Target rotates in respective planes according to the direction contrary with micro-shifting liquid pipe (4) circular motion；
When described device moves integrally, small objects follow the micro-shifting liquid pipe (4) to translate fortune together by microfluid vortex
It is dynamic.
4. generating the method that microfluid is used to operate small objects based on vibrational excitation, it uses dress as described in claim 1
It sets, it is characterised in that:
Small objects are placed on to the outside of the axial upper prong of the micro-shifting liquid pipe (4), Xiang Suoshu piezoelectric actuator (2) is defeated
Enter off-resonance voltage, the micro-shifting liquid pipe (4) micro-shifting liquid pipe (4) described in the driving lower edge of the piezoelectric actuator (2)
Length direction does one-dimensional of reciprocating vibration, and the micro-shifting liquid pipe (4) vibration makes liquid environment generate microfluid vortex, and small objects are leaned on
The absolute pressure of one side surface of nearly microfluid vortex centers is less than the other side, forms a direction being applied in small objects
The pressure of microfluid vortex centers pushes small objects axial to microfluid vortex along the micro-shifting liquid pipe (4) as force trapping
Center movement, until small objects high-pressure side stress and microfluid vortex reach balance to the reaction force of small objects；At this point,
The current gradient that micro-shifting liquid pipe (4) vibration generates microfluid vortex makes small objects in setting plane internal rotation；
When described device moves integrally, small objects follow the micro-shifting liquid pipe (4) to translate fortune together by microfluid vortex
It is dynamic.
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| CN201910156469.7A CN110090673A (en) | 2019-03-01 | 2019-03-01 | The device and method that microfluid is used to operate small objects is generated based on vibrational excitation |
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| CN201910156469.7A CN110090673A (en) | 2019-03-01 | 2019-03-01 | The device and method that microfluid is used to operate small objects is generated based on vibrational excitation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112973814A (en) * | 2021-03-03 | 2021-06-18 | 北京理工大学 | Interlayer automatic alignment bonding device and method for multilayer microfluidic chip |
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2019
- 2019-03-01 CN CN201910156469.7A patent/CN110090673A/en active Pending
Patent Citations (4)
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| CN102698679A (en) * | 2012-06-26 | 2012-10-03 | 南京航空航天大学 | Method for operating nano matters |
| CN105910560A (en) * | 2016-04-21 | 2016-08-31 | 长春理工大学 | Biological cell ultrasonic atomic force microscopic detection system and method |
| CN108303793A (en) * | 2018-01-12 | 2018-07-20 | 北京理工大学 | A kind of device and method for moving and rotating microscopic, spherical object |
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| CN112973814A (en) * | 2021-03-03 | 2021-06-18 | 北京理工大学 | Interlayer automatic alignment bonding device and method for multilayer microfluidic chip |
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Application publication date: 20190806 |