CN110090580A - Aramine injection device for formulating - Google Patents
Aramine injection device for formulating Download PDFInfo
- Publication number
- CN110090580A CN110090580A CN201910424115.6A CN201910424115A CN110090580A CN 110090580 A CN110090580 A CN 110090580A CN 201910424115 A CN201910424115 A CN 201910424115A CN 110090580 A CN110090580 A CN 110090580A
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- China
- Prior art keywords
- agitator tank
- cover
- aramine
- outlet tube
- splicing bucket
- Prior art date
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/211—Measuring of the operational parameters
- B01F35/2116—Volume
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2213—Pressure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/514—Mixing receptacles the mixing receptacle or conduit being transparent or comprising transparent parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7171—Feed mechanisms characterised by the means for feeding the components to the mixer using boxes, closable containers, sacks or carts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Accessories For Mixers (AREA)
Abstract
The invention discloses a kind of aramine injection device for formulating, it include: agitator tank, inside is equipped with the first agitating shaft, multiple first paddles, first motor, top is equipped with the first escape pipe, the first air inlet pipe, feed liquor cylinder, two the first openings, and bottom is equipped with the first outlet tube, the second outlet tube, third outlet tube；Two feeding mechanisms, two feeding mechanisms are respectively aramine feeding mechanism, sodium hydrogensulfite and sodium chloride feeding mechanism, and each feeding mechanism includes: waterproof electric cylinders, the first fixed frame, waterproof machine, L shape bar, cover board, splicing bucket, cover, wherein, when the splicing bucket open end is moved up towards the cover and protrudes into the cover to terminal, the cover board is connected to corresponding first and is open and closes the cover；Drain cylinder, coarse filtration mechanism；Thin filter mechanism；PH regulating mechanism.There is the present invention process for preparation to be located in completely enclosed space, the beneficial effect for avoiding aramine from being oxidized.
Description
Technical field
The present invention relates to aramine injection fields.It is more particularly related to a kind of liquor epinephrinae bitartratis ophthalmicus
Aramine injection device for formulating.
Background technique
Aramine is chemical name: (-)-α (1- aminoethyl) -3- salicylic alcohol bitartrate, weight wine
Stone acid aramine injection is highly prone to Oxidative demage in preparation, storage, transport and use process, leads to its effective component
Some or all of forfeiture influences patient's treatment.Therefore, how to avoid aramine in each process not by oxygen
Change, is the thorny problem preparing aramine injection and facing.
Summary of the invention
It is an object of the invention to solve at least the above problems, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of aramine injection device for formulating, prepare whole process and are in
In the closed space full of nitrogen, and during aramine is put into splicing bucket, be under conditions of nitrogen charging into
Capable, therefore can be oxidized in each link to avoid aramine.
In order to realize these purposes and other advantages according to the present invention, a kind of aramine injection is provided
Device for formulating, comprising:
Agitator tank, its underpart is in up big and down small truncated cone-shaped, and is used to accommodate the water for injection of logical nitrification, described to stir
It mixes tank to be arranged by bracket-suspending, the first vertical agitating shaft is equipped in the agitator tank, is located at first agitating shaft lower part
The first motor of multiple first paddles, driving the first agitating shaft rotation that divide, the agitator tank top is equipped with first and goes out
Tracheae, the first air inlet pipe, feed liquor cylinder, two first openings are laid with rubber layer, the agitator tank in the feed liquor medial wall of the tube
Bottom is equipped with the first outlet tube, the second outlet tube, third outlet tube, and the third outlet tube is flexibility, the third outlet tube
On be provided with valve；
Two feeding mechanisms, two feeding mechanisms are respectively aramine feeding mechanism, sodium hydrogensulfite and chlorine
Change sodium feeding mechanism, each feeding mechanism includes:
Waterproof electric cylinders are set in the agitator tank, and the waterproof electric cylinders are fixed at the top of the agitator tank, and are located at
The part of proximal wall is leaned in the agitator tank, the mobile terminal of the waterproof electric cylinders is arranged downwards, the shifting of the waterproof electric cylinders
First fixed frame of the opening towards first agitating shaft is fixed on moved end；
Waterproof machine is fixed in first fixed frame, the output shaft of the waterproof machine horizontally toward described
The setting of one agitating shaft；
L shape bar, integrally formed by orthogonal quarter butt and stock, the quarter butt is coaxially fixed on the waterproof machine
Output shaft on；
Cover board is horizontally disposed with, and the cover board is rounded, and the cover board is fixed on the free end of the stock, and position
Immediately below one of them first opening；
Splicing bucket, closed end are coaxially fixed on a surface of the cover board, when the bus of the splicing bucket is in perpendicular
When straight state, the splicing bucket is located at immediately below corresponding first opening；
Cover is located at outside the agitator tank, and the cover is located in corresponding first opening, the covering on top
It is provided with the second escape pipe, the second air inlet pipe, feed inlet, the feed inlet upper cover is equipped with material lid, and the internal diameter of the cover is greater than
The outer diameter of the splicing bucket, the length of the cover are greater than the length of the splicing bucket, wherein when the bus of the splicing bucket is in
When vertical state, the feed inlet is located at right above the splicing bucket；
Wherein, when the splicing bucket open end is moved up towards the cover and protrudes into the cover to terminal, institute
Cover board is stated to be connected to corresponding first opening and close the cover；
The length of the stock is arranged are as follows: when the splicing bucket away from the cover be moved downward to its completely disengage it is described
When cover, the waterproof machine drives the quarter butt rotation, when the splicing bucket moving in rotation not with the agitator tank, described the
One agitating shaft, first paddle contact；
Drain cylinder is set in the agitator tank, and the drain cylinder is by covering at the cambered surface stirred on pot sidewall
The plate body of shape is formed with the stirring pot sidewall, and the plate body upper end is sealingly fastened at the top of the agitator tank, the drain cylinder
Top is equipped with inlet tube and water inlet pipe, the drain cylinder lower end closed, and is provided with the 4th outlet tube, the top part of plate body
Side wall on be provided with multiple stomatas being connected to the agitator tank, the plate body is higher than first paddle；
Coarse filtration mechanism, liquid feeding end are connected to by connecting tube flexible with first outlet tube, the coarse filtration machine
The outlet end of structure is connected to by connecting tube flexible with the inlet tube, and the coarse filtration mechanism is for filtering out partial size greater than 3 μm
Impurity；
Thin filter mechanism, liquid feeding end are connected to by connecting tube flexible with second outlet tube, the thin filter
The outlet end of structure is connected to by connecting tube flexible with nitrogen charging encapsulating device, and the thin filter mechanism is greater than for filtering out partial size
0.22 μm of impurity；
PH regulating mechanism comprising the tubule being arranged on the feed liquor cylinder is slided in sealing, lower end is connected in the tubule
The hollow of upper end is fixed on the sliding block set on the sliding block on fluid column inner sidewall, lower end for fluid column, sealing sliding sleeve
On push rod, be fixed on the pushing block of the push rod upper end, wherein it is described to be closed for fluid column upper surface, and through-hole is set, it is described to push away
Bar sliding is arranged in described on liquid column pipe upper surface, the tubule lower end is lower than the feed liquor cylinder, and the tubule upper end is higher than
The feed liquor cylinder, the tubule is equipped with valve, described to receive the solution for having the root containing liquor epinephrinae bitartratis ophthalmicus for fluid column content, the push rod
Length setting are as follows: when the sliding block, which moves down, to abut to described for liquid column bottom, the pushing block is higher than described for fluid column；
Wherein, first escape pipe, first air inlet pipe, first outlet tube, second outlet tube, described
Second escape pipe, the inlet tube, the water inlet pipe, is equipped with valve and pump on the 4th outlet tube at second air inlet pipe, institute
It states the first air inlet pipe and second air inlet pipe is connected to nitrogen supply (NS) device, the injection of the water inlet pipe and logical nitrification
Water supply connection.
It preferably, further include dissolution mechanism comprising: the second agitating shaft for being set in the agitator tank is set to
Second motor of the second paddle, driving the second agitating shaft rotation on second agitating shaft, second agitating shaft
It is obliquely installed on the side wall of an agitator tank, the free end of second agitating shaft is higher than its fixing end, second motor
It is fixed by the second fixed frame being fixed on the side wall outside the agitator tank.
Preferably, the splicing bucket inner wall is in half ellipsoidal surface shape, and the splicing bucket inner wall is laid with glassy layer.
Preferably, the coarse filtration mechanism and the thin filter mechanism are stud filter.
Preferably, the feeding mechanism further includes observation window, and the observation window is set on the stirring pot sidewall, institute
Observation window upper end is stated higher than the waterproof electric cylinders, the observation window lower end is lower than on the first paddle of highest position
End, the projection of the feeding mechanism horizontally toward first agitating shaft are located at the observation window and horizontally toward described first stir
In the drop shadow spread of axis.
Preferably, it is described for fluid column be it is transparent, it is described for fluid column be equipped with volume markings.
The present invention is include at least the following beneficial effects:
The first, whole process is prepared in the closed space full of nitrogen, and is put into splicing bucket in aramine
It in the process, is to be carried out under conditions of nitrogen charging, therefore can be oxidized in each link to avoid aramine.
The second, tubule is protruded into the solution of the prepared root containing liquor epinephrinae bitartratis ophthalmicus, pulls push rod, extract root containing liquor epinephrinae bitartratis ophthalmicus
Solution in fluid column, and be full of, be then shut off valve, tubule is inserted into feed liquor cylinder, realizes that the adjustment process of pH value is complete
Full starvation.
Third protrudes into the splicing bucket of two feeding mechanisms in cover, and cover closure first is open, and opens material lid, will be by
The load weighted aramine of formula rate is put into the splicing bucket of a feeding mechanism, and sodium hydrogensulfite and sodium chloride are put
Enter in the splicing bucket of another feeding mechanism, cover material lid, intracorporal air is covered in extraction respectively, nitrogen is filled with, until in cover
Only nitrogen, and reach certain pressure, realize the complete starvation of fill process.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the longitdinal cross-section diagram of the device for formulating of one of technical solution of the invention；
Fig. 2 is the longitdinal cross-section diagram of the feeding mechanism of one of technical solution of the invention；
Fig. 3 is the detail view of the pH regulating mechanism of one of technical solution of the invention.
Specific embodiment
Present invention will be described in further detail below with reference to the accompanying drawings, to enable those skilled in the art referring to specification text
Word can be implemented accordingly.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, institute
Reagent and material are stated, unless otherwise specified, is commercially obtained；In the description of the present invention, the orientation of term instruction
Or positional relationship is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of description of the present invention and simplification of the description, and
It is not that the device of indication or suggestion meaning or element must have a particular orientation, be constructed and operated in a specific orientation, therefore
It is not considered as limiting the invention.
As shown in Figures 1 to 3, the present invention provides a kind of aramine injection device for formulating, comprising:
Agitator tank 1, its underpart is in up big and down small truncated cone-shaped, and is used to accommodate the water for injection of logical nitrification, described
Agitator tank 1 is arranged by bracket-suspending, and the first vertical agitating shaft is equipped in the agitator tank 1, is located at first agitating shaft
The first motor that multiple first paddles, driving first agitating shaft of lower part rotate, the first paddle is for stirring note
It penetrates and uses water, the first escape pipe 11, the first air inlet pipe 12,13, two first, feed liquor cylinder openings, institute are equipped at the top of the agitator tank 1
State and be laid with rubber layer on 13 inner sidewall of feed liquor cylinder, 1 bottom of agitator tank be equipped with the first outlet tube 14, the second outlet tube 15,
Third outlet tube 16, the third outlet tube 16 are flexibility, are provided with valve on the third outlet tube 16；First escape pipe 11
For extracting the air in agitator tank 1, i.e. oxygen out, the first air inlet pipe 12 for inputting in nitrogen to agitator tank 1, use by feed liquor cylinder 13
In the solution of input root containing liquor epinephrinae bitartratis ophthalmicus, to adjust the pH value of aramine solution, the first outlet tube 14 is for exporting
The aramine solution of high concentration after mixing evenly for the first time, the second outlet tube 15 are equal for exporting second of stirring
The aramine solution of low concentration after even, third outlet tube 16 out of a mixing bowl for exporting sample liquid, to detect weight
Whether Metaraminol Bitartrate solution meets the indices of aramine injection；
Two feeding mechanisms 2, two feeding mechanisms 2 be respectively aramine feeding mechanism 2, sodium hydrogensulfite and
Sodium chloride feeding mechanism 2, each feeding mechanism 2 include:
Waterproof electric cylinders 21 are set in the agitator tank 1, and the waterproof electric cylinders 21 are fixed on the agitator tank 1 and push up
Portion, and it is located at the part that proximal wall is leaned in the agitator tank 1, the mobile terminal of the waterproof electric cylinders 21 is arranged downwards, described
First fixed frame 22 of the opening towards first agitating shaft is fixed on the mobile terminal of waterproof electric cylinders 21；Waterproof electric cylinders 21
For driving the first fixed frame 22 to move up and down；
Waterproof machine 23 is fixed in first fixed frame 22, and the output shaft of the waterproof machine 23 is horizontally toward
The first agitating shaft setting；
L shape bar 24, integrally formed by orthogonal quarter butt and stock, the quarter butt is coaxially fixed on the anti-water power
On the output shaft of machine 23；Waterproof machine 23 is for driving quarter butt to rotate；
Cover board 25 is horizontally disposed with, and the cover board 25 is rounded, and the cover board 25 is fixed on the free end of the stock
On, and be located in one of immediately below the first opening；Cover board 25 is open for fixing splicing bucket 26, and for closing first,
So that splicing bucket 26 can be located in the cavity of a sealing；
Splicing bucket 26, closed end are coaxially fixed on a surface of the cover board 25, as the mother of the splicing bucket 26
When line state in a vertical shape, the splicing bucket 26 is located at immediately below corresponding first opening；Splicing bucket 26 is used to accept solid material,
Such as aramine or sodium hydrogensulfite and sodium chloride；
Cover 27 is located at outside the agitator tank 1, and the cover 27 is located in corresponding first opening, the cover
The second escape pipe 28, the second air inlet pipe 29, feed inlet are provided at the top of body 27, the feed inlet upper cover is equipped with material lid 20, described
The internal diameter of cover 27 is greater than the outer diameter of the splicing bucket 26, and the length of the cover 27 is greater than the length of the splicing bucket 26,
In, when the bus of the splicing bucket 26 state in a vertical shape, the feed inlet is located at right above the splicing bucket 26；By recipe ratio
The load weighted aramine of example or sodium hydrogensulfite and sodium chloride can enter in splicing bucket 26 from material lid 20, close
Material lid 20 is closed, the second escape pipe 28 is used to extract out the air in cover 27, i.e. oxygen, and the second air inlet pipe 29 is for inputting nitrogen
To cover 27, when there was only nitrogen in cover 27, when the pressure in cover 27 is consistent with the pressure in agitator tank 1, stop filling
Nitrogen；
Wherein, when 26 open end of splicing bucket is moved up towards the cover 27 and protrudes into the cover 27 to terminal
When, the cover board 25 is connected to corresponding first and is open and closes the cover 27；
The length of the stock is arranged are as follows: completely disengages when the splicing bucket 26 is moved downward to it away from the cover 27
When the cover 27, the waterproof machine 23 drives the quarter butt to rotate, and when 26 moving in rotation of splicing bucket does not stir with described
Mix tank 1, first agitating shaft, first paddle contact；
Drain cylinder 3 is set in the agitator tank 1, and the drain cylinder 3 is by covering on 1 side wall of agitator tank
The plate body of arc surfaced is formed with 1 side wall of agitator tank, and the plate body upper end is sealingly fastened in 1 top of agitator tank, described
Inlet tube 31 and water inlet pipe 32 are equipped at the top of drain cylinder 3, inlet tube 31 is for inputting the first time through coarse filtration after mixing evenly
High concentration aramine solution, water inlet pipe 32 is used to input the water for injection of the measured logical nitrification of volume,
3 lower end closed of drain cylinder, and it is provided with the 4th outlet tube 33, the 4th outlet tube 33 is used for will be between the liquor epinephrinae bitartratis ophthalmicus of high concentration
Hydroxylamine solution and water for injection are input in agitator tank 1, are provided with and multiple are stirred on the side wall of the top part of plate body with described
The stomata 34 for mixing the connection of tank 1, for balancing the pressure between drain cylinder 3 and agitator tank 1, the plate body is higher than first stirring
Leaf；
Coarse filtration mechanism 4, liquid feeding end are connected to by connecting tube flexible with first outlet tube 14, the coarse filtration
The outlet end of mechanism 4 is connected to by connecting tube flexible with the inlet tube 31, and the coarse filtration mechanism 4 is big for filtering out partial size
In 3 μm of impurity；For filtering the aramine solution of high concentration；
Thin filter mechanism 5, liquid feeding end are connected to by connecting tube flexible with second outlet tube 15, the thin filtering
The outlet end of mechanism 5 is connected to by connecting tube flexible with nitrogen charging encapsulating device, and the thin filter mechanism 5 is big for filtering out partial size
In 0.22 μm of impurity；For filtering the aramine solution of low concentration；
PH regulating mechanism 6 comprising the tubule 61 being arranged on the feed liquor cylinder 13 is slided in sealing, lower end is connected to described
61 upper end of tubule it is hollow for fluid column 62, that sealing sliding sleeve is set to the sliding block 63 on 62 inner sidewall of fluid column, lower end is solid
Due on the sliding block 63 push rod 64, be fixed on the pushing block 65 of 64 upper end of push rod, wherein it is described for 62 upper surface of fluid column
Closing, and through-hole 66 is set, the sliding of push rod 64 is arranged in described on 62 pipe upper surface of fluid column, 61 lower end of tubule is low
In the feed liquor cylinder 13,61 upper end of tubule is higher than the feed liquor cylinder 13, and the tubule 61 is equipped with valve, the feed flow
Accommodate the solution of the root containing liquor epinephrinae bitartratis ophthalmicus in column 62, the length setting of the push rod 64 are as follows: when the sliding block 63 move down to
When being connected to 62 bottom for fluid column, the pushing block 65 is higher than described for fluid column 62；For hydroxyl between the liquor epinephrinae bitartratis ophthalmicus to low concentration
The solution of amine aqueous solution input root containing liquor epinephrinae bitartratis ophthalmicus makes the pH value 3.2 of the aramine solution of low concentration to adjust pH
~3.5；
Wherein, first escape pipe 11, first air inlet pipe 12, first outlet tube 14, described second go out liquid
Pipe 15, second escape pipe 28, second air inlet pipe 29, the inlet tube 31, the water inlet pipe 32, the 4th outlet tube 33
On be equipped with valve and pump, first air inlet pipe 12 and second air inlet pipe 29 are connected to nitrogen supply (NS) device, described
Water inlet pipe 32 is connected to the water for injection feeding mechanism of logical nitrification.
In the above-mentioned technical solutions, protrude into the splicing bucket 26 of two feeding mechanisms 2 in cover 27, cover board 25 is closed
First opening opens material lid 20, will be put into connecing for a feeding mechanism 2 by the load weighted aramine of formula rate
In charging basket 26, sodium hydrogensulfite and sodium chloride are put into the splicing bucket 26 of another feeding mechanism 2, are covered material lid 20, are taken out respectively
Air in cover 27 out, is filled with nitrogen, until only nitrogen in cover 27, and reach certain pressure, it is spare；
Then pH regulating mechanism 6 is installed, tubule 61 is protruded into the solution of the prepared root containing liquor epinephrinae bitartratis ophthalmicus, pulls push rod
64, the solution of the root containing liquor epinephrinae bitartratis ophthalmicus is extracted in fluid column 62, and be full of, be then shut off valve, tubule 61 is inserted into feed liquor cylinder
It is spare in 13；
Prepare agitator tank 1, extract the air in agitator tank 1 out, input in nitrogen to agitator tank 1, makes there was only nitrogen in agitator tank 1
Gas, and the pressure in pressure and cover 27 is essentially identical；
Water inlet pipe 32 and the 4th outlet tube 33 are opened, the injection for being formulated the logical nitrification of measured a part is pressed in input
Water, water for injection enter part under agitator tank 1 by the 4th outlet tube 33, close water inlet pipe 32 and the 4th outlet tube 33, open
Dynamic waterproof electric cylinders 21 drive the first fixed frame 22 to be moved downward to splicing bucket 26 and completely disengage the stopping of cover 27, then start waterproof
Motor 23 drives quarter butt to turn to 180 ° of the rotation of splicing bucket 26, and sodium hydrogensulfite and sodium chloride is made to fall into injection in agitator tank 1
In water, after resetting splicing bucket 26, starting first motor drives the rotation of the first agitating shaft axis, stirring to sodium hydrogensulfite and chlorination
Sodium is completely dissolved, and in the same way, falls the feeding mechanism for being placed with aramine 2 by aramine
Under, after resetting splicing bucket 26, continues stirring and be completely dissolved to aramine, obtain hydroxyl between the liquor epinephrinae bitartratis ophthalmicus of high concentration
Amine aqueous solution；
The valve and pump of the first outlet tube 14 are opened, coarse filtration mechanism 4 is started, carries out coarse filtration, filtered high concentration
Aramine solution enter in drain cylinder 3, after the completion of filtering, close the first outlet tube 14 on valve and
Pump closes valve and pump on inlet tube 31, opens the 4th outlet tube 33, makes the aramine of filtered high concentration
Solution re-enters into agitator tank 1, is then shut off the 4th outlet tube 33, opens water inlet pipe 32, makes remaining injection moisture
Repeatedly enter in drain cylinder 3 and enter back into agitator tank 1, to rinse drain cylinder 3, makes hydroxyl between the liquor epinephrinae bitartratis ophthalmicus of the high concentration remained in
Amine aqueous solution continues to stir completely into agitator tank 1, obtains the aramine solution of low concentration, goes out to infuse pipe from third
It is middle to take out a small amount of sample liquid, indices are obtained to detect pH value, if pH value not between 3.2~3.5, is opened on tubule 61
Valve, push pushing block 65, enter the solution containing liquor epinephrinae bitartratis ophthalmicus root in agitator tank 1, and stir evenly, until pH value
It is 3.2~3.5, then opens the second outlet tube 15, the nitrogen charging encapsulating after the filtering of thin filter mechanism 5,100 DEG C of flowing steam sterilizings
15min hunts leak in condition of the vacuum degree lower than 80kPa, is cooled to 30 DEG C hereinafter, progress lamp inspection, prints packet after qualified.
In above-mentioned process for preparation, whole process is put in the closed space full of nitrogen in aramine
It is to be carried out under conditions of nitrogen charging, therefore avoid aramine quilt in each link during entering splicing bucket 26
Oxidation.It further include dissolution mechanism 7 in another technical solution comprising: the second stirring being set in the agitator tank 1
Axis, the second paddle being set on second agitating shaft, driving second agitating shaft rotation the second motor, described the
Two agitating shafts are obliquely installed on the side wall of an agitator tank 1, and the free end of second agitating shaft is higher than its fixing end, described
Second motor is fixed by the second fixed frame being fixed on the side wall outside the agitator tank 1.In order to accelerate solution rate, if
Rotation direction and the second agitating shaft of the first agitating shaft at an angle are set, the different mixing power effect in direction can promote
Into the diversity of the water for injection direction of motion, to promote to dissolve.
In another technical solution, 26 inner wall of splicing bucket is in half ellipsoidal surface shape, 26 inner wall of the splicing bucket laying
There is glassy layer.The smooth surface of glass material and the shape of half ellipsoidal surface shape are all conducive to solid material and are detached from and fall into injection
With in water.
In another technical solution, the coarse filtration mechanism 4 and the thin filter mechanism 5 are stud filter.Titanium
Stick filter has the advantages of resistance to strong acid, resistance to highly basic, corrosion-resistant and filter core iterative regenerable uses.
In another technical solution, the feeding mechanism 2 further includes observation window, and the observation window is set to the stirring
On 1 side wall of tank, the observation window upper end is higher than the waterproof electric cylinders 21, and the observation window lower end, which is lower than, is located at highest position
The first paddle upper end, it is horizontal that the projection of the feeding mechanism 2 horizontally toward first agitating shaft is located at the observation window
Towards in the drop shadow spread of first agitating shaft.Facilitate the preparation situation in observation agitator tank 1.
In another technical solution, it is described for fluid column 62 be it is transparent, it is described for fluid column 62 be equipped with volume markings.Side
Just it observes for the liquid case in fluid column 62, can also quantitatively know the molten of the root containing liquor epinephrinae bitartratis ophthalmicus for adjusting pH value of addition
The amount of liquid, to draw preparation experience.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (6)
1. aramine injection device for formulating characterized by comprising
Agitator tank, its underpart is in up big and down small truncated cone-shaped, and is used to accommodate the water for injection of logical nitrification, the agitator tank
It is arranged by bracket-suspending, the first vertical agitating shaft, the part under first agitating shaft is equipped in the agitator tank
Multiple first paddles, driving first agitating shaft rotation first motor, be equipped at the top of the agitator tank the first escape pipe,
First air inlet pipe, feed liquor cylinder, two first openings are laid with rubber layer, the stirring pot bottom in the feed liquor medial wall of the tube
Equipped with the first outlet tube, the second outlet tube, third outlet tube, the third outlet tube is flexibility, is set on the third outlet tube
It is equipped with valve；
Two feeding mechanisms, two feeding mechanisms are respectively aramine feeding mechanism, sodium hydrogensulfite and sodium chloride
Feeding mechanism, each feeding mechanism include:
Waterproof electric cylinders are set in the agitator tank, and the waterproof electric cylinders are fixed at the top of the agitator tank, and are located at described
The part of proximal wall is leaned in agitator tank, the mobile terminal of the waterproof electric cylinders is arranged downwards, the mobile terminal of the waterproof electric cylinders
On be fixed with first fixed frame of the opening towards first agitating shaft；
Waterproof machine is fixed in first fixed frame, and the output shaft of the waterproof machine horizontally toward described first stirs
Mix axis setting；
L shape bar, integrally formed by orthogonal quarter butt and stock, the quarter butt is coaxially fixed on the defeated of the waterproof machine
On shaft；
Cover board is horizontally disposed with, and the cover board is rounded, and the cover board is fixed on the free end of the stock, and
It is located in one of immediately below the first opening；
Splicing bucket, closed end are coaxially fixed on a surface of the cover board, when the bus of the splicing bucket is in a vertical shape
When state, the splicing bucket is located at immediately below corresponding first opening；
Cover is located at outside the agitator tank, and the cover is located in corresponding first opening, the covering on top setting
There are the second escape pipe, the second air inlet pipe, feed inlet, the feed inlet upper cover is equipped with material lid, and the internal diameter of the cover is greater than described
The outer diameter of splicing bucket, the length of the cover are greater than the length of the splicing bucket, wherein when the bus of the splicing bucket is in vertical
When state, the feed inlet is located at right above the splicing bucket；
Wherein, when the splicing bucket open end is moved up towards the cover and protrudes into the cover to terminal, the lid
Plate is connected to corresponding first and is open and closes the cover；
The length of the stock is arranged are as follows: completely disengages the cover when the splicing bucket is moved downward to it away from the cover
When, the waterproof machine drives the quarter butt rotation, and when splicing bucket moving in rotation does not stir with the agitator tank, described first
Mix axis, first paddle contact；
Drain cylinder is set in the agitator tank, and the drain cylinder is by the arc surfaced that covers on the stirring pot sidewall
Plate body is formed with the stirring pot sidewall, and the plate body upper end is sealingly fastened at the top of the agitator tank, at the top of the drain cylinder
Equipped with inlet tube and water inlet pipe, the drain cylinder lower end closed, and it is provided with the 4th outlet tube, the side of the top part of plate body
Multiple stomatas being connected to the agitator tank are provided on wall, the plate body is higher than first paddle；
Coarse filtration mechanism, liquid feeding end are connected to by connecting tube flexible with first outlet tube, the coarse filtration mechanism
Outlet end is connected to by connecting tube flexible with the inlet tube, and the coarse filtration mechanism is used to filter out partial size miscellaneous greater than 3 μm
Matter；
Thin filter mechanism, liquid feeding end are connected to by connecting tube flexible with second outlet tube, the thin filter mechanism
Outlet end is connected to by connecting tube flexible with nitrogen charging encapsulating device, and the thin filter mechanism is for filtering out partial size greater than 0.22 μm
Impurity；
PH regulating mechanism comprising the tubule being arranged on the feed liquor cylinder is slided in sealing, lower end is connected in the tubule upper end
Hollow be set to the sliding block on fluid column inner sidewall, lower end for fluid column, sealing sliding sleeve and be fixed on the sliding block
Push rod, the pushing block for being fixed on the push rod upper end, wherein it is described to be closed for fluid column upper surface, and through-hole, the pusher slide are set
Dynamic to be arranged in described on liquid column pipe upper surface, the tubule lower end is lower than the feed liquor cylinder, the tubule upper end is higher than described
Feed liquor cylinder, the tubule is equipped with valve, described to receive the solution for having the root containing liquor epinephrinae bitartratis ophthalmicus for fluid column content, the length of the push rod
Setting are as follows: when the sliding block, which moves down, to abut to described for liquid column bottom, the pushing block is higher than described for fluid column；
Wherein, first escape pipe, first air inlet pipe, first outlet tube, second outlet tube, described second
Escape pipe, the inlet tube, the water inlet pipe, is equipped with valve and pump on the 4th outlet tube at second air inlet pipe, and described
One air inlet pipe and second air inlet pipe are connected to nitrogen supply (NS) device, and the water for injection of the water inlet pipe and logical nitrification supplies
Device is answered to be connected to.
2. aramine injection device for formulating as described in claim 1, which is characterized in that further include dissolution machine
Structure comprising: the second agitating shaft for being set in the agitator tank, the second paddle being set on second agitating shaft,
The second motor of the second agitating shaft rotation is driven, second agitating shaft is obliquely installed on the side wall of an agitator tank,
The free end of second agitating shaft is higher than its fixing end, and second motor passes through the side wall that is fixed on outside the agitator tank
On the second fixed frame fix.
3. aramine injection device for formulating as described in claim 1, which is characterized in that the splicing bucket inner wall
In half ellipsoidal surface shape, the splicing bucket inner wall is laid with glassy layer.
4. aramine injection device for formulating as described in claim 1, which is characterized in that the coarse filtration mechanism
It is stud filter with the thin filter mechanism.
5. aramine injection device for formulating as described in claim 1, which is characterized in that the feeding mechanism is also
Including observation window, the observation window is set on the stirring pot sidewall, and the observation window upper end is higher than the waterproof electric cylinders, institute
It states observation window lower end to be lower than positioned at the first paddle upper end of highest position, the feeding mechanism horizontally toward described first stirs
The projection of axis is mixed in the observation window horizontally toward drop shadow spread of first agitating shaft.
6. aramine injection device for formulating as described in claim 1, which is characterized in that described to be for fluid column
Bright, it is described to be equipped with volume markings for fluid column.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910424115.6A CN110090580B (en) | 2019-05-21 | 2019-05-21 | Preparation device of m-hydroxylamine bitartrate injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910424115.6A CN110090580B (en) | 2019-05-21 | 2019-05-21 | Preparation device of m-hydroxylamine bitartrate injection |
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| CN110090580A true CN110090580A (en) | 2019-08-06 |
| CN110090580B CN110090580B (en) | 2020-06-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910424115.6A Active CN110090580B (en) | 2019-05-21 | 2019-05-21 | Preparation device of m-hydroxylamine bitartrate injection |
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| CN101569607A (en) * | 2009-06-16 | 2009-11-04 | 中国药科大学 | Di-demethoxycurcumin precursor liposome and preparation method thereof |
| JP2014180625A (en) * | 2013-03-19 | 2014-09-29 | Fujiyakuhin Co Ltd | Aseptic emulsification system |
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