CN110090358A - Blood magnetic stimulating device - Google Patents

Blood magnetic stimulating device Download PDF

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Publication number
CN110090358A
CN110090358A CN201810084819.9A CN201810084819A CN110090358A CN 110090358 A CN110090358 A CN 110090358A CN 201810084819 A CN201810084819 A CN 201810084819A CN 110090358 A CN110090358 A CN 110090358A
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CN
China
Prior art keywords
blood
container
stem cell
stimulating
neural stem
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810084819.9A
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Chinese (zh)
Inventor
傅坤梅
何康伟
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Bonitas Research Center Co Ltd
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Bonitas Research Center Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonitas Research Center Co Ltd filed Critical Bonitas Research Center Co Ltd
Priority to CN201810084819.9A priority Critical patent/CN110090358A/en
Publication of CN110090358A publication Critical patent/CN110090358A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/02Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Abstract

The invention discloses a kind of blood magnetic stimulating devices, it includes have a Neural stem cell unit, the Neural stem cell unit has a stimulating coil and may be disposed on a blood supply unit, or directly it is worn on user, the stimulating coil is also connected with an impulse generating unit simultaneously, the stimulating coil is excited for one pulse current of output, in the way of electromagnetic pulse, to the blood for flowing through the Neural stem cell unit, or the blood in user veins beneath the skin carries out strength but of short duration Neural stem cell, whereby, can not only in blood viremia virusemia and related disease carry out magnetization treatment, and compared to existing haemodialysis device, severe pain will not be generated by the way of Neural stem cell, there is no sense of discomfort, it is highly-safe, and it is easier to be received by patient.

Description

Blood magnetic stimulating device
Technical field
The present invention be it is related with a kind of magnetic stimulating device, particularly relate to a kind of directly carry out strength but of short duration magnetic to blood The blood magnetic stimulating device of stimulation.
Background technique
The document of the aspect of related hematologic disease treatment at present, common for blood dialysis, cardinal principle is to utilize blood The permeable membrane or hollow fiber membrane of liquid dialysis machine, to be filtered to blood, to remove metabolic waste in blood and miscellaneous Matter, but this mode be only used for the bodies such as kidney failure sufferer or septicemia can not Self-discharged harmful toxic matter the case where, it is right In viremia virusemia and related disease in blood, such as AIDS, viral encephalitis, virus hepatitis, trigeminal neuralgia and band-like Bleb etc. is not effective.
In view of this, it is thus proposed that it can be powered to blood, to eliminate the idea for the virus being likely to be present in blood, But the mode of this direct-electrifying, it is not only abnormally dangerous, and electric current stimulation can generate severe pain, can not be received by sufferer, more very Person may destroy blood composition, therefore on feasibility study, be only used for special status, such as when the common people contribute blood, be used for It sterilizes to acquired blood, therefore, inventor is after observing the above results, it is believed that existing hematologic disease is controlled Device is treated, there is a need for improvement, and has generation of the invention then.
Summary of the invention
The purpose of the present invention is to provide a kind of blood magnetic stimulating devices, directly can carry out strength to blood but of short duration magnetic Stimulation, in blood viremia virusemia and related disease carry out magnetization treatment, and compared with existing haemodialysis device, no Severe pain can be generated, does not have sense of discomfort, is highly-safe.
In order to achieve the above object, blood magnetic stimulating device provided by the present invention, includes: a Neural stem cell unit, magnetic thorn Swashing unit has a container, and a chamber is equipped in the container, be equipped with outside the container entrance that is connected with the chamber with One exports, and is equipped with a stimulating coil around the chamber on the container;And a blood supply unit, the blood supply unit have It may connect to the input pipe between the blood vessel of a user and the entrance of the container, and may connect to the outlet of the container and be somebody's turn to do The intervascular efferent duct of user, constitutes the chamber for sequentially passing through the input pipe, the container by the blood of the user whereby Room, the efferent duct return a blood flow paths of the blood vessel of the user, are also serially connected with a blood in the blood flow paths Liquid helps Pu, for driving the endovascular blood to flow along the blood flow paths;There are also an impulse generating unit, which is produced Raw unit is electrically connected at the stimulating coil, excites the stimulating coil to generate time-varying magnetic field for one pulse current of output, with logical Electromagnetic induction method is crossed in generating induction field in the chamber, and then can produce induced current, with to flowing through the indoor blood of the chamber Liquid carries out strength but of short duration Neural stem cell.
Preferably, wherein the container forms a long cylindricality, and is respectively equipped with the entrance in the both ends of the container With the outlet, which is the outside that the container is surrounded on along the length direction of the container.
Preferably, wherein also include anticoagulation side Pu, anticoagulation side Pu is connected to the blood flow road On diameter, for inject an anticoagulation medicine.
Preferably, wherein also include a bubble monitor, which is connected to the blood flow road On diameter, for monitor in blood with the presence or absence of bubble.
Preferably, wherein also include a resistance valve, which is connected in the blood flow paths, can For to block the blood flow paths.
Preferably, wherein also include several pressure sensors, which is connected to the blood On flow path, for monitor the blood pressure in the blood flow paths.
Preferably, wherein the impulse generating unit includes a high-voltage DC power supply, and the high-voltage DC power supply is logical It crosses a charging circuit and is connected with a capacitor, which is connected to the stimulating coil by a discharge circuit, the impulse generating unit It also include a control module, which has the charge switch for being set to the charging circuit, and is set to this and puts One discharge switch of circuit, the discharge circuit are connected with a branch circuit, which is equipped with a shaping pulse module, this The outer charging circuit is equipped with a current-limiting resistance and the discharge circuit is equipped with a coil resistance, which is equipped with a branch Resistance.
In order to achieve the above object, including the present invention also provides a kind of blood magnetic stimulating device: a Neural stem cell unit, it should Neural stem cell unit has a cyclic annular wear, and is to be surrounded by a wearing space between the inner wall of the ring-type wear, for wearing It is placed on a user, while being equipped with a stimulating coil around the wearing space on the ring-type wear;And one pulse produce Raw unit, the impulse generating unit are electrically connected at the stimulating coil, excite the stimulating coil to produce for one pulse current of output Raw time-varying magnetic field, with by electromagnetic induction method in generating induction field in the wearing space, and then can be subcutaneous in the user Intravascular generation induced current, to carry out strength to the endovascular blood but of short duration Neural stem cell.
Preferably, wherein also include a soft liner, which is located on the ring-type wear Inner wall.
Preferably, wherein the impulse generating unit includes a high-voltage DC power supply, and the high-voltage DC power supply is logical It crosses a charging circuit and is connected with a capacitor, which is connected to the stimulating coil by a discharge circuit, the impulse generating unit It also include a control module, which has the charge switch for being set to the charging circuit, and is set to this and puts One discharge switch of circuit, the discharge circuit are connected with a branch circuit, which is equipped with a shaping pulse module, this The outer charging circuit is equipped with a current-limiting resistance and the discharge circuit is equipped with a coil resistance, which is equipped with a branch Resistance.
Blood magnetic stimulating device provided by the present invention, can be defeated by the blood of the user by the blood supply unit It send to the chamber of the container, then operates the impulse generating unit again and export the pulse current and excite the stimulating coil, with logical It crosses electromagnetic induction method and Neural stem cell is carried out to the blood for flowing through the chamber, and then can be to all viremia virusemias and phase in blood Related disorders, such as AIDS, viral encephalitis, virus hepatitis, trigeminal neuralgia and shingles zoster, carry out magnetization treatment, and another The ring-type wear can then be worn on the user by a kind of outer embodiment, then by excite the stimulating coil generate when Varying magnetic field with directly in the subcutaneous intravascular generation induced current of the user, and then can pass through non-invasive internal electromagnetic pulse The mode for the treatment of carries out blood magnetization treatment, wherein by the way of Neural stem cell, usual each pulse is only lasted for less than several millis Second, how many energy are not carried, so compared to existing haemodialysis device severe pain will not be generated, without sense of discomfort, safety Property it is high, and be easier to be received by patient.
Detailed description of the invention
Fig. 1 is the equipment connection schematic diagram of the first preferred embodiment of the invention.
Fig. 2 is the circuit diagram of the impulse generating unit of the first preferred embodiment of the invention.
Fig. 3 is the experimental data table of the first preferred embodiment of the invention.
Fig. 4 is the equipment connection schematic diagram of the second preferred embodiment of the invention.
Fig. 5 is the equipment connection schematic diagram of third preferred embodiment of the invention.
Symbol description in attached drawing:
100 blood magnetic stimulating devices;10 Neural stem cell units;11 containers;12 chambers;121 entrances;122 outlets;13 thorns Swash coil;14 cyclic annular wears;141 wearing spaces;15 soft liners;20 impulse generating units;21 high voltage direct currents Source;22 charging circuits;221 current-limiting resistances;23 capacitors;24 discharge circuits;241 coil resistances;25 control modules;251 Charge switch;252 discharge switches;26 branch circuits;261 branch resistances;27 shaping pulse modules;28 display modules;29 Operation module;30 blood supply units;31 input pipes;311 Fistula pipe needles;32 efferent ducts;321 Fistula pipe needles;33 blood side Pu;40 anticoagulations help Pu;50 bubble monitors;60 resistance valves;70 pressure sensors;200 users;T blood flow Path.
Specific embodiment
It please refers to shown in Fig. 1 and Fig. 2, is the equipment connection schematic diagram and pulse of the first preferred embodiment of the invention The circuit diagram of unit is generated, announcement has a kind of blood magnetic stimulating device 100, which includes:
One Neural stem cell unit 10 has a container 11, and is equipped with a chamber 12 in the container 11, which is equipped with outside and should The entrance 121 and one that chamber 12 is connected exports 122, surrounds the chamber 12 on the container 11 and is equipped with a stimulating coil 13, in In the present embodiment, which forms a long cylindricality, preferably to be cylindrical, and is respectively equipped with this in the both ends of the container 11 Entrance 121 and the outlet 122, while the stimulating coil 13 is to be surrounded on the outer of the container 11 along the length direction of the container 11 Side.
One impulse generating unit 20, the impulse generating unit 20 are electrically connected at the stimulating coil 13, wherein such as Fig. 2 institute Show, which includes a high-voltage DC power supply 21, which is connected by a charging circuit 22 It is connected to a capacitor 23, which is connected to the stimulating coil 13 by a discharge circuit 24, which also wraps Containing a control module 25, which has the charge switch 251 for being set to the charging circuit 22, and is set to One discharge switch 252 of the discharge circuit 24, the discharge circuit 24 are connected with a branch circuit 26, which is equipped with one Shaping pulse module 27, furthermore the charging circuit 22 is equipped with a current-limiting resistance 221 and the discharge circuit 24 is equipped with coil electricity Resistance 241, the branch circuit 26 are equipped with a branch resistance 261.
One blood supply unit 30, having may connect between the blood vessel of a user 200 and the entrance 121 of the container 11 One input pipe 31, and may connect to the outlet 122 of the container 11 and the intervascular efferent duct 32 of the user 200, it borrows This, which is constituted, sequentially passes through the input pipe 31, the chamber 12 of the container 11, the efferent duct 32 by the blood of the user 200, then returns To a blood flow paths T of the blood vessel of the user 200, wherein the input pipe 31 and the efferent duct 32 usually pass through one Fistula pipe needle 311,321 is connected to the vein of the user 200, and blood side Pu is furthermore also serially connected on blood flow paths T 33, for driving the endovascular blood to flow along blood flow paths T.
One anticoagulation helps Pu 40, is connected on blood flow paths T, for inject an anticoagulation medicine.
One bubble monitor 50 is connected on blood flow paths T, for monitor in blood with the presence or absence of gas Bubble.
One resistance valve 60 is connected on blood flow paths T, for block blood flow paths T.
Several pressure sensors 70 are connected on blood flow paths T, for monitor blood flow paths T On blood pressure.
Please again while refering to fig. 1 and shown in Fig. 2, when using the blood magnetic stimulating device 100, first first by the input Pipe 31 and the efferent duct 32 are connected to the blood vessel of the user 200 by the Xie Fistula pipe needle 311,321, and being normally coupled to this makes The vein of user 200 starts blood side Pu 33 later, allows blood side Pu 33 to extract the endovascular blood, and driving should Blood is flowed along blood flow paths T, and first flows into the chamber 12 by the entrance 121 via the input pipe 31, then gone out by this The chamber 12 is discharged in mouth 122, and comes back to the blood vessel of the user 200 along the efferent duct 32, while starting pulse generation Unit 20, the parameter for setting the control module 25 according to user, control open the charge switch 251 and close the electric discharge and opens 252 are closed, the high-voltage DC power supply 21 is allowed to carry out charging energy-storing to the capacitor 23, or closes the charge switch 251 and opens and be somebody's turn to do Discharge switch 252, to discharge the electric energy stored by the capacitor 23, and an exportable pulse current excites the stimulating coil 13 to generate Time-varying magnetic field, and by electromagnetic induction method in generating induction field in the chamber 12, and then can produce induced current, with convection current Strength is carried out through the blood in the chamber 12 but of short duration Neural stem cell whereby can be to all viremia virusemias and phase in blood Related disorders, such as AIDS, viral encephalitis, virus hepatitis, trigeminal neuralgia and shingles zoster, carry out magnetization treatment, wherein Above-listed viremia virusemia is only citing, not limits the scope of the patents of the invention, hereby give notice that.
It is the experimental data table of the first preferred embodiment of the invention referring again to shown in Fig. 3, it is of the invention in order to verify Actual effect, in a neuroblastoma culture experiment, daily acquisition observation Neural stem cell group is thin with no Neural stem cell group for we Born of the same parents' spot quantity completes the growth rate tables of data of herpes simplex virus as shown in Figure 3, by can be seen that in the tables of data, magnetic The cell spot quantity of stimulation group was effectively suppressed at first 8 days, is indicated that virus can be magnetized in early stage proliferation period by Neural stem cell and is treated Inhibited.
Equipment referring again to shown in Fig. 4 and Fig. 5, being the second preferred embodiment and third preferred embodiment of the invention Connection schematic diagram, the present embodiment and aforementioned first preferred embodiment the difference is that, which has one cyclic annular Wear 14, and be to be surrounded by a wearing space 141 between the inner wall of the ring-type wear 14, for being set in the user With 200, such as foot shown in arm shown in Fig. 4 or Fig. 5, the wearing space is still around on the ring-type wear 14 141 are equipped with the stimulating coil 13, and it is to be located on the ring-type wear that blood magnetic stimulating device, which also includes a soft liner 15, 14 inner wall dresses the comfort when Neural stem cell unit 10 for increasing, and the impulse generating unit 20 is electrically connected at The stimulating coil 13 excites the stimulating coil 13 to generate time-varying magnetic field, to pass through electromagnetic induction side for exporting the pulse current Formula, and then can be in the subcutaneous intravascular generation induced current of the user, with right in generating induction field in the wearing space 141 The endovascular blood carries out strength but of short duration Neural stem cell, whereby, compared to body used by aforementioned first preferred embodiment Outer magnetization is treated, second and third preferred embodiment in the present invention can be carried out by way of non-invasive internal electromagnetic pulse treatment Blood magnetization treatment.
It is noted that the impulse generating unit 20 can also be equipped with a display module 28 and an operation module 29, it can For setting to show with input parameters, to design and control charge and discharge electric frequency, and because the impulse generating unit 20 is It is controlled using switch, it is possible to allow entire circuit to maintain high voltage direct current environment, so generate not only the pulse single The efficiency of supply of member 20 can achieve 80% or more, and does not need setting transformer and can export the voltage of kilovolt easily.
It is worth being mentioned that again, by the way of Neural stem cell, usual each pulse only lasts for not carrying more less than several milliseconds Few energy so will not generate severe pain compared to existing haemodialysis device, not have sense of discomfort, is highly-safe, and is easier Received by patient.
Although the present invention is disclosed with preferred embodiment, so it is not intended to limiting the invention, any to be familiar with this skill Personage, without departing from the spirit and scope of the present invention, when various changes and modification, therefore protection scope of the present invention can be made Subject to being defined depending on appended claims.

Claims (10)

1. a kind of blood magnetic stimulating device, which is characterized in that include:
One Neural stem cell unit has a container, and is equipped with a chamber in the container, is equipped with outside the container and is connected with the chamber An entrance and an outlet, be equipped with a stimulating coil around the chamber on the container;
One blood supply unit has the input pipe being connected between the blood vessel of a user and the entrance of the container, Yi Jilian It is connected to outlet and the intervascular efferent duct of the user of the container, constitutes sequentially passed through by the blood of the user whereby The input pipe, the chamber of the container, the efferent duct, return a blood flow paths of the blood vessel of the user, the blood stream Blood side Pu is also serially connected on dynamic path, for driving the endovascular blood to flow along the blood flow paths;
One impulse generating unit, the impulse generating unit are electrically connected at the stimulating coil, should for output one pulse current excitation Stimulating coil generates time-varying magnetic field, to pass through electromagnetic induction in generating induction field in the chamber, to generate induced current, with right It flows through the indoor blood of the chamber and carries out Neural stem cell.
2. blood magnetic stimulating device according to claim 1, which is characterized in that wherein, which forms a long cylindricality, and It is respectively equipped with the entrance and the outlet in the both ends of the container, which is to be surrounded on this along the length direction of the container The outside of container.
3. blood magnetic stimulating device according to claim 1, which is characterized in that it also include anticoagulation side Pu wherein, Anticoagulation side Pu is connected in the blood flow paths, to inject an anticoagulation medicine.
4. blood magnetic stimulating device according to claim 1, which is characterized in that it also include a bubble monitor wherein, The bubble monitor is connected in the blood flow paths, to monitor in blood with the presence or absence of bubble.
5. blood magnetic stimulating device according to claim 1, which is characterized in that also include a resistance valve, the resistance wherein Stream valve is connected in the blood flow paths, to block the blood flow paths.
6. blood magnetic stimulating device according to claim 1, which is characterized in that also include several pressure sensings wherein Device, which is connected in the blood flow paths, to monitor the blood pressure in the blood flow paths.
7. blood magnetic stimulating device according to claim 1, which is characterized in that wherein, which includes One high-voltage DC power supply, the high-voltage DC power supply are connected with a capacitor by a charging circuit, which passes through a discharge circuit It is connected to the stimulating coil, which also includes a control module, which, which has, is set to the charging One charge switch of circuit, and it is set to a discharge switch of the discharge circuit, which is connected with a branch circuit, The branch circuit is equipped with a shaping pulse module, which is equipped with a current-limiting resistance, which is equipped with coil electricity Resistance, the branch circuit are equipped with a branch resistance.
8. a kind of blood magnetic stimulating device, which is characterized in that include:
One Neural stem cell unit has a cyclic annular wear, and is to be surrounded by a wearing space between the inner wall of the ring-type wear, For being set in a user, a stimulating coil is equipped with around the wearing space on the ring-type wear;
One impulse generating unit, the impulse generating unit are electrically connected at the stimulating coil, should for output one pulse current excitation Stimulating coil generates time-varying magnetic field, to pass through electromagnetic induction in generating induction field in the wearing space, in user's skin Under intravascular generation induced current, to carry out Neural stem cell to the endovascular blood.
9. blood magnetic stimulating device according to claim 8, which is characterized in that it also include a soft liner wherein, it should Soft liner is the inner wall for being located on the ring-type wear.
10. blood magnetic stimulating device according to claim 8, which is characterized in that wherein, which includes One high-voltage DC power supply, the high-voltage DC power supply are connected with a capacitor by a charging circuit, which passes through a discharge circuit It is connected to the stimulating coil, which also includes a control module, which, which has, is set to the charging One charge switch of circuit, and it is set to a discharge switch of the discharge circuit, which is connected with a branch circuit, The branch circuit is equipped with a shaping pulse module, which is equipped with a current-limiting resistance, which is equipped with coil electricity Resistance, the branch circuit are equipped with a branch resistance.
CN201810084819.9A 2018-01-29 2018-01-29 Blood magnetic stimulating device Pending CN110090358A (en)

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US20030195453A1 (en) * 2002-04-10 2003-10-16 James Han Access disconnection systems and methods
US6663585B1 (en) * 1997-09-06 2003-12-16 Fresenius Medical Care Deutschland Gmbh Method and device for monitoring vessel access during extracorporeal blood treatment
US20050159638A1 (en) * 2000-09-29 2005-07-21 Delisle Clarence A. Method and device for treating body ailments
US20050177203A1 (en) * 2003-11-14 2005-08-11 Brighton Carl T. Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
US20100099942A1 (en) * 2008-10-20 2010-04-22 Lucas Portelli Method and apparatus for electromagnetic human and animal immune stimulation and/or repair systems activation
CN102178986A (en) * 2011-04-13 2011-09-14 李明 Blood extracorporeal circulation magnetic sterilizing device
US20140263064A1 (en) * 2013-03-15 2014-09-18 Fresenius Medical Care Holdings, Inc. Medical fluid sensors and related systems and methods
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CN204767052U (en) * 2015-05-25 2015-11-18 秦松发 Blood adhesion therapeutic instrument
JP2017018153A (en) * 2015-07-07 2017-01-26 株式会社Ifg Medical magnetic pulse generation device having quick adjustment circuit for charge voltage
JP2017176860A (en) * 2008-08-27 2017-10-05 デカ・プロダクツ・リミテッド・パートナーシップ Hemodialysis systems and operation control methods therefor

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048451A1 (en) * 1980-09-24 1982-03-31 121873 Canada Inc. Electro-magnetic therapeutic system and method
JPS60100978A (en) * 1983-10-17 1985-06-04 イレクトロ‐バイオロジー,インコーポレイテツド Method and apparatus for controlling blood recirculating action in body
WO1991016941A1 (en) * 1990-05-04 1991-11-14 Bio Magnetic Therapy Sys Inc Magnetic field therapy and apparatus
US6663585B1 (en) * 1997-09-06 2003-12-16 Fresenius Medical Care Deutschland Gmbh Method and device for monitoring vessel access during extracorporeal blood treatment
CN1274610A (en) * 2000-06-29 2000-11-29 张肇庆 Blood magnetotherapy method and apparatus
US20050159638A1 (en) * 2000-09-29 2005-07-21 Delisle Clarence A. Method and device for treating body ailments
US20030195453A1 (en) * 2002-04-10 2003-10-16 James Han Access disconnection systems and methods
US20050177203A1 (en) * 2003-11-14 2005-08-11 Brighton Carl T. Method and device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip
JP2017176860A (en) * 2008-08-27 2017-10-05 デカ・プロダクツ・リミテッド・パートナーシップ Hemodialysis systems and operation control methods therefor
US20100099942A1 (en) * 2008-10-20 2010-04-22 Lucas Portelli Method and apparatus for electromagnetic human and animal immune stimulation and/or repair systems activation
US20140302482A1 (en) * 2009-11-23 2014-10-09 Dan Dietz Electromagnetic blood preservation and storage
CN102178986A (en) * 2011-04-13 2011-09-14 李明 Blood extracorporeal circulation magnetic sterilizing device
US9005151B2 (en) * 2011-09-07 2015-04-14 Choon Kee Lee Thermal apparatus
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