CN110090325A - A kind of medical guiding wire hydrophilic coating formula and its preparation process - Google Patents
A kind of medical guiding wire hydrophilic coating formula and its preparation process Download PDFInfo
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- CN110090325A CN110090325A CN201910316148.9A CN201910316148A CN110090325A CN 110090325 A CN110090325 A CN 110090325A CN 201910316148 A CN201910316148 A CN 201910316148A CN 110090325 A CN110090325 A CN 110090325A
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- guiding wire
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/06—Coatings containing a mixture of two or more compounds
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Materials For Medical Uses (AREA)
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Abstract
The present invention provides a kind of medical guiding wire hydrophilic coating formula and its preparation process, including solvent and solute, the solute includes the raw material of following mass percents: 5~15% crosslinking agents, 5~20% tert-butyl hydroperoxide, 0.1~0.8% frerrous chloride, 0.5~2% ascorbic acid, 4~16% polyvinylpyrrolidones, 0.1~0.5% dodecyl sodium sulfate;Solvent is acetone and water;A kind of preparation process of medical guiding wire, including raw material preparation process and hydrophilic coating coating procedure;The raw material preparation process includes the preparation of solution A, solution B and solution C, and the hydrophilic coating coating procedure includes cross-linking reaction, graft reaction.It is big using the hydrophilic coating sheet of heretofore described hydrophilic coating formula preparation and the surface adhesion force of medical guiding wire, and coating is not easily to fall off, good hydrophilic property;And the hydrophilic coating is stablized, and the hydrophilic coating formula is able to satisfy various requirements, long using time and holding time;The preparation process is simple, easily operated.
Description
Technical field
The invention belongs to chemical technology field, in particular to a kind of medical guiding wire hydrophilic coating formula and its preparation process.
Background technique
With the development of blood vessel intervention class medical instrument, occur more and more medical guiding wires now, such as micro-wire, respectively
The delivery sheath of kind of bracket or embolism protector, these seal wires are all need to proceed to human body various intravascular, in order to improve
The resistance that this kind of blood compatibility and reduction seal wire with the medical guiding wire of contacting blood is walked in the blood vessels, it is necessary to this kind of
The surface of seal wire is handled, its surface is made to have hydrophilic ability.
Currently, hydrophilic coating used in medical guiding wire mostly uses a kind of parent comprising isocyanates, polyvalent alcohol, PVP etc.
Water coating solution, its solvent used is the volatile organic solvents such as methylene chloride in this recipe, and the resting period is short, in temperature
Volatile quantity sharply increases in the environment of higher than 30 DEG C, therefore limits its use condition, and organic solvent has medical guiding wire
Certain corrosivity influences the service life of seal wire;One kind hydrophilic painting as made of support polymer and hydrophilic polymer crosslinking
Layer liquid is also medical guiding wire often with hydrophilic coating formula, but the lubricant effect of the medical guiding wire of this coating solution is used only to be able to maintain
For 24 hours, it is unable to satisfy the demand of the medical guiding wire used for a long time;And between both the above hydrophilic coating and medical guiding wire surface
Adhesive force it is smaller, hydrophily is poor, and hydrophilic coating is be easy to cause to fall off.
Summary of the invention
The present invention provides a kind of medical guiding wire hydrophilic coating formula and its preparation process, using the hydrophilic coating formula system
Standby hydrophilic coating and medical guiding wire surface adhesion force are big, good hydrophilic property, and the hydrophilic painting prepared using the coating formula
Layer is not easily to fall off;The hydrophilic coating formulation stable, the medical guiding wire with hydrophilic coating prepared using the coating formula
Various requirements are able to satisfy, it is long using time and holding time;The preparation process is simple, easily operated.
A kind of medical guiding wire hydrophilic coating formula, including solvent and solute, the solute include following mass percents
Raw material: 5~15% crosslinking agents, 5~20% tert-butyl hydroperoxide, 0.1~0.8% frerrous chloride, 0.5~2% ascorbic acid,
4~16% polyvinylpyrrolidones, 0.1~0.5% dodecyl sodium sulfate;Solvent is acetone and water.
It advanced optimizes, the solute in a kind of medical guiding wire hydrophilic coating formula includes the raw material of following mass percents:
10% crosslinking agent, 15% tert-butyl hydroperoxide, 0.2% frerrous chloride, 1% ascorbic acid, 4% polyvinylpyrrolidone,
0.1% dodecyl sodium sulfate.
It advanced optimizes, crosslinking agent used is ethylene glycol dimethacrylate.
A kind of preparation process of medical guiding wire includes raw material preparation process and hydrophilic coating coating procedure;
Wherein raw material preparation process includes: that 5~20% tert-butyl hydroperoxide and 5~15% friendships are added in acetone soln
Join agent, after mixing obtained solution A;0.1~0.8% frerrous chloride, 0.5~2% ascorbic acid, 4 are added in aqueous solution
~16% polyvinylpyrrolidone, after mixing, obtained solution B;0.1~0.5% dodecyl sulphur is added in aqueous solution
Sour sodium, after mixing, obtained solution C;
Hydrophilic coating coating procedure the following steps are included:
(1) medical guiding wire that will be cleaned up immerses in solution A, carries out cross-linking reaction;
(2) medical guiding wire that will complete step (1) immerses in solution B, carries out graft reaction;
(3) medical guiding wire that will complete step (2) immerses in solution C, removes polyethylene pyrrole non-grafted on medical guiding wire
Pyrrolidone;
(4) medical guiding wire for completing step (3) is rinsed with physiological buffer, it is after the completion of flushing that medical guiding wire is true
Sky is dry.
It advanced optimizes, in the step (1) in hydrophilic coating coating procedure, the medical guiding wire is anti-in solution A
It is 120min between seasonable, reaction temperature is room temperature.
It advanced optimizes, in the step (2) in hydrophilic coating coating procedure, the medical guiding wire is anti-in solution B
It is 60min between seasonable, reaction temperature is room temperature.
It advanced optimizes, in the step (3) in hydrophilic coating coating procedure, the medical guiding wire impregnates in solution C
Time is 5min.
The invention has the benefit that heretofore described hydrophilic coating formula includes crosslinking agent, tert-butyl hydroperoxide
Hydrogen, frerrous chloride, ascorbic acid, polyvinylpyrrolidone, dodecyl sodium sulfate, acetone, water;Wherein tert-butyl hydroperoxide
It can be with the Fe in frerrous chloride2+Redox reaction is carried out to generate free radicals, and free radical is that polyvinylpyrrolidone can cure
With stablizing the initiator that is grafted on seal wire, and in being grafted, free radical can be consumed, and free radical is very few then
Influence grafting rate;Ascorbic acid, the Fe that ascorbic acid generates in reduction reaction are added in the present invention3+It can guarantee enough
Fe2+It is reacted with tert-butyl hydroperoxide, ensure that always has enough free radicals in grafting process, grafting rate is improved, from
And to form uniform hydrophilic coating on the surface of medical guiding wire, and ascorbic acid can also exist for polyvinylpyrrolidone
The grafting process on medical guiding wire surface provides good electron donor, improves hydrophilic coating in the attachment fastness of medical guiding wire, makes
Hydrophilic coating is not susceptible to fall off and the hydrophilic coating is stablized, and use heretofore described hydrophilic coating formula system
The standby medical guiding wire with hydrophilic coating is able to satisfy various requirements, long using time and holding time;
The preparation process of medical guiding wire in the present invention with hydrophilic coating, required condition is not high, the control in preparation process
Variable processed is few, need to only be monitored to reaction time and reaction temperature, therefore heretofore described preparation process is simple
It is easy to control, convenient for promoting in the industrial production.
Specific embodiment
Below with reference to technical effect of the embodiment to the design of the technical program, specific structure and generation carry out it is clear,
It is fully described by, to be completely understood by the purpose, feature and effect of the technical program.
Embodiment 1
A kind of medical guiding wire hydrophilic coating formula, including solvent and solute, the solute include following mass percents
Raw material: 10% crosslinking agent, 15% tert-butyl hydroperoxide, 0.2% frerrous chloride, 1% ascorbic acid, 8% polyvinylpyrrolidine
Ketone, 0.1% dodecyl sodium sulfate;Crosslinking agent used is ethylene glycol dimethacrylate.
A kind of preparation process of medical guiding wire includes raw material preparation process and hydrophilic coating coating procedure;
Wherein raw material preparation process includes: that 15% tert-butyl hydroperoxide and 10% crosslinking agent are added in acetone soln,
Obtained solution A after mixing;0.2% frerrous chloride, 1% ascorbic acid, 8% polyvinylpyrrolidine are added in aqueous solution
Ketone, after mixing, obtained solution B;0.1% dodecyl sodium sulfate, after mixing, obtained solution are added in aqueous solution
C;
Hydrophilic coating coating procedure the following steps are included:
(1) medical guiding wire that will be cleaned up immerses in solution A, progress cross-linking reaction, reaction temperature 120min, instead
It is room temperature between seasonable;
(2) medical guiding wire that will complete step (1) immerses in solution B, progress graft reaction, reaction temperature 60min, instead
It is room temperature between seasonable;
(3) medical guiding wire that will complete step (2) immerses in solution C, soaking time 5min;
(4) medical guiding wire for completing step (3) is rinsed with physiological buffer, it is after the completion of flushing that medical guiding wire is true
Sky is dry.
Wherein medical guiding wire used is PU seal wire.
Embodiment 2
A kind of medical guiding wire hydrophilic coating formula, including solvent and solute, the solute include following mass percents
Raw material: 5% crosslinking agent, 8% tert-butyl hydroperoxide, 0.2% frerrous chloride, 0.6% ascorbic acid, 4% polyvinylpyrrolidine
Ketone, 0.2% dodecyl sodium sulfate;Solvent is acetone and water;Crosslinking agent used is ethylene glycol dimethacrylate;Solvent is
Acetone and water.
A kind of preparation process of medical guiding wire includes raw material preparation process and hydrophilic coating coating procedure;
Wherein raw material preparation process includes: that 15% tert-butyl hydroperoxide and 10% crosslinking agent are added in acetone soln,
Obtained solution A after mixing;0.2% frerrous chloride, 1% ascorbic acid, 8% polyvinylpyrrolidine are added in aqueous solution
Ketone, after mixing, obtained solution B;0.1% dodecyl sodium sulfate, after mixing, obtained solution are added in aqueous solution
C;
Hydrophilic coating coating procedure the following steps are included:
(1) medical guiding wire that will be cleaned up immerses in solution A, progress cross-linking reaction, reaction temperature 120min, instead
It is room temperature between seasonable;
(2) medical guiding wire that will complete step (1) immerses in solution B, progress graft reaction, reaction temperature 60min, instead
It is room temperature between seasonable;
(3) medical guiding wire that will complete step (2) immerses in solution C, soaking time 5min;
(4) medical guiding wire for completing step (3) is rinsed with physiological buffer, it is after the completion of flushing that medical guiding wire is true
Sky is dry.
Wherein medical guiding wire used is PU seal wire.
Embodiment 3
A kind of medical guiding wire hydrophilic coating formula, including solvent and solute, the solute include following mass percents
Raw material: 13% crosslinking agent, 18% tert-butyl hydroperoxide, 0.6% frerrous chloride, 1.3% ascorbic acid, 4% polyvinyl pyrrole
Alkanone, 0.3% dodecyl sodium sulfate;Solvent is acetone and water;Crosslinking agent used is ethylene glycol dimethacrylate.
A kind of preparation process of medical guiding wire includes raw material preparation process and hydrophilic coating coating procedure;
Wherein raw material preparation process includes: that 15% tert-butyl hydroperoxide and 10% crosslinking agent are added in acetone soln,
Obtained solution A after mixing;0.2% frerrous chloride, 1% ascorbic acid, 8% polyvinylpyrrolidine are added in aqueous solution
Ketone, after mixing, obtained solution B;0.1% dodecyl sodium sulfate, after mixing, obtained solution are added in aqueous solution
C;
Hydrophilic coating coating procedure the following steps are included:
(1) medical guiding wire that will be cleaned up immerses in solution A, progress cross-linking reaction, reaction temperature 120min, instead
It is room temperature between seasonable;
(2) medical guiding wire that will complete step (1) immerses in solution B, progress graft reaction, reaction temperature 60min, instead
It is room temperature between seasonable;
(3) medical guiding wire that will complete step (2) immerses in solution C, soaking time 5min;
(4) medical guiding wire for completing step (3) is rinsed with physiological buffer, it is after the completion of flushing that medical guiding wire is true
Sky is dry.
Wherein medical guiding wire used is PU seal wire.
Surface wettability test is carried out to medical guiding wire made from embodiment 1, the contact angle on its surface and water is surveyed and rubs
Wipe coefficient;And medical guiding wire common on the market is chosen, it is marked as comparative example 1, moistened surface equally is carried out to comparative example 1
The contact angle and coefficient of friction of its surface and water are surveyed in performance test;The surface wettability of embodiment 1 and comparative example 1, which is tested, to be tied
Fruit is as shown in table 1.
1 comparative example 1 of table and 1 surface wettability test result of embodiment
Group | With the contact angle of water | Coefficient of friction |
Comparative example 1 | 95.4 | 0.98 |
Embodiment 1 | 46.8 | 0.06 |
The contact angle of medical guiding wire surface and water described in embodiment 1 is 46.8 ° as can be seen from Table 1, and is rubbed
Coefficient is small, this illustrates that medical guiding wire surface described in embodiment 1 has good hydrophily;And medical in comparative example 1 is led
The contact angle of silk table face and water is 95.4 °, hence it is evident that greater than the value in embodiment 1, this illustrates the present embodiment 1 and existing market tradition
Medical guiding wire hydrophilicity it is more preferable.
The better embodiment of the technical program is illustrated above, but the technical program be not limited to it is described
Embodiment, those skilled in the art can also make various equivalent changes under the premise of without prejudice to the technical program spirit
Type or replacement, these equivalent variation or replacement are all included in the scope defined by the claims of the present application.
Claims (7)
1. a kind of medical guiding wire hydrophilic coating formula, which is characterized in that including solvent and solute, the solute includes following quality
The raw material of percentage: 5~15% crosslinking agents, 5~20% tert-butyl hydroperoxide, 0.1~0.8% frerrous chloride, 0.5~2%
Ascorbic acid, 4~16% polyvinylpyrrolidones, 0.1~0.5% dodecyl sodium sulfate;Solvent is acetone and water.
2. a kind of medical guiding wire hydrophilic coating formula according to claim 1, which is characterized in that the solute includes following
The raw material of mass percent: 10% crosslinking agent, 15% tert-butyl hydroperoxide, 0.2% frerrous chloride, 1% ascorbic acid, 4%
Polyvinylpyrrolidone, 0.1% dodecyl sodium sulfate.
3. according to claim 1 or a kind of medical guiding wire hydrophilic coating formula as claimed in claim 2, which is characterized in that used
Crosslinking agent is ethylene glycol dimethacrylate.
4. a kind of preparation process of medical guiding wire, which is characterized in that including raw material preparation process and hydrophilic coating coating procedure;
Wherein raw material preparation process includes: that 5~20% tert-butyl hydroperoxide and 5~15% crosslinkings are added in acetone soln
Agent, after mixing obtained solution A;In aqueous solution be added 0.1~0.8% frerrous chloride, 0.5~2% ascorbic acid, 4~
16% polyvinylpyrrolidone, after mixing, obtained solution B;0.1~0.5% dodecyl sodium sulfonate is added in aqueous solution
Sodium, after mixing, obtained solution C;
Hydrophilic coating coating procedure the following steps are included:
(1) medical guiding wire that will be cleaned up immerses in solution A, carries out cross-linking reaction;
(2) medical guiding wire that will complete step (1) immerses in solution B, carries out graft reaction;
(3) medical guiding wire that will complete step (2) immerses in solution C;
(4) medical guiding wire for completing step (3) is rinsed with physiological buffer, does medical guiding wire vacuum after the completion of flushing
It is dry.
5. a kind of preparation process of medical guiding wire according to claim 4, which is characterized in that in hydrophilic coating coating procedure
In step (1) in, reaction time of the medical guiding wire in solution A be 120min, reaction temperature is room temperature.
6. a kind of preparation process of medical guiding wire according to claim 4, which is characterized in that in hydrophilic coating coating procedure
In step (2) in, reaction time of the medical guiding wire in solution B be 60min, reaction temperature is room temperature.
7. a kind of preparation process of medical guiding wire according to claim 4, which is characterized in that in hydrophilic coating coating procedure
In step (3) in, the medical guiding wire in solution C soaking time be 5min.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111790048A (en) * | 2020-08-14 | 2020-10-20 | 中国人民解放军总医院第五医学中心 | Urethra dilatation catheter and medical instrument comprising same |
CN115137947A (en) * | 2022-06-30 | 2022-10-04 | 惠州市顺美医疗科技有限公司 | Guide wire and continuous preparation method of coating thereof |
Citations (2)
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CN1455802A (en) * | 2001-01-26 | 2003-11-12 | 株式会社日本触媒 | Water absorbing agent and method for production thereof and water absorbing article |
WO2005115489A2 (en) * | 2004-05-24 | 2005-12-08 | Genzyme Corporation | Adherent polymeric compositions |
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2019
- 2019-04-19 CN CN201910316148.9A patent/CN110090325A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1455802A (en) * | 2001-01-26 | 2003-11-12 | 株式会社日本触媒 | Water absorbing agent and method for production thereof and water absorbing article |
WO2005115489A2 (en) * | 2004-05-24 | 2005-12-08 | Genzyme Corporation | Adherent polymeric compositions |
Non-Patent Citations (1)
Title |
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王小妹,伍雪芬,周宇: "医用聚氨酯导管表面亲水涂层的合成研究", 《中国医疗器械信息》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111790048A (en) * | 2020-08-14 | 2020-10-20 | 中国人民解放军总医院第五医学中心 | Urethra dilatation catheter and medical instrument comprising same |
CN115137947A (en) * | 2022-06-30 | 2022-10-04 | 惠州市顺美医疗科技有限公司 | Guide wire and continuous preparation method of coating thereof |
CN115137947B (en) * | 2022-06-30 | 2023-04-11 | 惠州市顺美医疗科技有限公司 | Guide wire and continuous preparation method of coating thereof |
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