CN110075368B - A kind of preparation method of anti-sticking film on the surface of electric knife - Google Patents

Abstract

The invention discloses a preparation method of an anti-sticking film layer on the surface of an electrotome, which comprises the steps of preparing a priming layer, arranging a conductive layer on the priming layer, and arranging an anti-sticking layer on the conductive layer to prepare the anti-sticking film layer; the bottom layer is an Ag layer, the conductive film layer is a mixed layer of SiO2 and Ag, and the anti-sticking layer is an Au or Ag film layer; preparing a SiO2 and Ag mixed layer with a nano-scale columnar matrix on the electrotome, and locking a large amount of air molecules between nano-columns of the mixed layer to ensure that most of the contact surface between small intestine tissues and the electrotome is air, namely generating an air cushion between the small intestine tissues and the electrotome, thereby achieving the purpose of adhesion prevention; the anti-sticking film layer prepared by the preparation method has low resistivity, high temperature resistance and oxidation resistance, meets the thermal shock test, and has small anti-sticking attenuation; in the process of hemostasis of the electrotome, the anti-sticking film layer prepared by the preparation method of the anti-sticking film layer on the surface of the electrotome ensures that the electrotome can not be adhered with a mucosa, avoids damaging the mucosa and ensures the hemostasis effect.

Description

A kind of preparation method of anti-sticking film on the surface of electric knife

technical field

The invention relates to a method for preparing a film layer, in particular to a method for preparing an anti-sticking film layer on the surface of an electric knife.

Background technique

The cutting principle of the high-frequency electric knife used in surgery is to use high-frequency pulsed electric sparks to cut human tissue. The specific working principle is: the two poles of the high-frequency pulse power supply are respectively connected to the electrosurgical knife and the human body. When the pulse voltage is applied between the electrosurgical knife and the small intestine tissue, the body fluid at the nearest point is broken down to form a discharge channel. Due to the small cross-sectional area of the channel and the extremely short discharge time, the energy is highly concentrated, and the instantaneous high temperature generated in the discharge area is enough to fuse the local small intestinal tissue. After the end of the first pulse, after a short time interval, the second pulse taps through and discharges the nearest electrode between the other poles, fuses the deeper layer of small intestinal tissue. Such a high-frequency cycle is repeated over and over again, and finally the effect of removing the target tissue is achieved.

During the pulse discharge process of the electric knife, a part of the electric energy is released to the electric knife, and the electric energy is rapidly converted into heat energy, which causes the temperature of the electric knife to rise. At the same time, there is a non-contact discharge between the electrosurgical knife and the small intestine tissue, and the heat energy of the electrosurgical knife cannot be absorbed by the small intestinal tissue; because the electrosurgical knife is small in size and has a small heat capacity, the temperature of the electrosurgical knife can reach 800°C without external coolant. ℃ or higher (redness).

When the reddened electric knife is in contact with the small intestinal tissue again, it can instantly carbonize and denature fat and protein; these carbonized and denatured products have strong adhesion, which can firmly stick the electric knife, and when it is forcibly pulled out During electrocautery, a part of the good intestinal tissue is often pulled out, creating a new wound, so the surgeon needs to re-use the electrocautery to stop the bleeding of the new wound, but the electrocautery may be stuck again.

In order to solve the problem of electric knife sticking, it is one of the effective solutions to prepare anti-stick coating on the electric knife. At present, electrosurgical knives on the market mostly use inert metals such as gold-plated or silver-plated, but the effect is not good.

Therefore, it is urgent to prepare a membrane layer disposed on the surface of the electrode tip of the electrosurgical knife, which can better solve the problem of adhesion between the electrode tip of the electrosurgical knife and the small intestine tissue.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a preparation method of anti-sticking mucous layer on the surface of electric knife, aiming at solving the problem that the existing hemostatic electrode is plated with inert metal such as gold or silver on the surface, and the anti-sticking effect of small intestinal tissue is not good.

The technical scheme of the present invention is as follows: a preparation method of the anti-sticking film layer on the surface of an electric knife, wherein, the obtained anti-sticking film layer is applied on the high-frequency electric knife, and specifically comprises the following steps:

A1: make the bottom layer;

A2: Prepare a conductive layer of nano-scale columnar matrix on the surface of the primer layer;

A3: A release layer is provided on the top surface of the nano-pillars of the conductive layer to obtain a release film layer.

In the preparation method of the anti-sticking film layer on the surface of the electric knife, wherein, the primer layer adopts an Ag material layer.

In the preparation method of the anti-sticking film layer on the surface of the electro-knife, the conductive layer adopts a mixed layer of SiO ₂ and nano-Ag with a nano-scale columnar matrix.

In the preparation method of the anti-sticking film layer on the surface of the electric knife, wherein, the anti-sticking layer adopts an Ag material layer or an Au material layer.

The preparation method of the anti-sticking film layer on the surface of the electric knife, wherein, the SiO ₂ and nano-Ag mixed layer specifically includes the following components: tetraethyl orthosilicate 12-16%; water≤1%; HCL≤1 %; NH4OH ≤1%; nano-silver paste 1-5%; the rest are absolute ethanol.

The preparation method of the anti-sticking film layer on the surface of the electric knife, wherein the SiO ₂ and nano-Ag mixed layer is prepared by a sol-gel method.

The preparation method of the anti-sticking film layer on the surface of the electric knife, wherein, the preparation method of the SiO2 and nano-Ag mixed layer comprises the following steps:

a1: slowly drop tetraethyl orthosilicate into water, hydrochloric acid, NH4OH and absolute ethanol to form the precursor tetraethyl silicate;

a2: adding the nano-silver paste to the precursor tetraethyl silicate to obtain a mixed solution;

a3: The mixed solution is fully stirred and dispersed by ultrasonic to obtain a mixed wet gel of SiO2 and nano-Ag.

In the preparation method of the anti-sticking film layer on the surface of the electric knife, the particle size of the nano-silver paste is 20-30 nm.

The preparation method of the anti-sticking film layer on the surface of the electric knife, wherein, in the step a2, the volume ratio of nano Ag is 5-20%.

The preparation method of the anti-sticking film layer on the surface of the electro-knife, wherein, a layer of primer is firstly electroplated on the surface of the hemostatic head, and then a conductive layer of a nano-level columnar matrix is prepared on the surface of the primer by a sol-gel method. , and finally a layer of anti-sticking layer is electroplated on the top surface of the nano-pillars of the conductive layer.

Beneficial effects of the present invention: The present invention provides a method for preparing an anti-sticking film layer on the surface of an electric knife to prepare a primer layer, a conductive layer is arranged on the primer layer, and an anti-stick layer is arranged on the conductive layer to prepare an anti-stick layer. Adhesive film layer; the bottom layer is Ag layer, the conductive film layer is SiO2 and Ag mixed layer, and the anti-adhesion layer is Au or Ag film layer; a layer of SiO2 and Ag mixed layer with nano-level columnar matrix is prepared on the electric knife , a large number of air molecules are locked between the nano-pillars of the mixed layer, so that most of the contact surface between the small intestine tissue and the electric knife is air, which is equivalent to generating a layer of air cushion between the two, so as to achieve the purpose of anti-sticking ; The anti-adhesion film layer obtained by the preparation method of the anti-adhesion film layer on the surface of the electric knife has low resistivity, high temperature resistance, anti-oxidation, meets the thermal shock test, and the anti-adhesive film attenuation is very small; The anti-adhesion mucous layer obtained by the preparation method of the anti-adhesion mucous layer on the surface of the electric knife ensures that the electric knife will not adhere to the mucous membrane, avoids damage to the mucous membrane, and ensures the hemostatic effect.

Description of drawings

FIG. 1 is a schematic diagram of the structure of the non-stick mucosal hemostatic electrosurgical knife in the gastrointestinal tract of the present invention.

Figure 2 is a schematic structural diagram of the anti-adhesion film layer on the surface of the electrosurgical knife in the present invention.

FIG. 3 is a flow chart of the steps of the preparation method of the anti-sticking film layer on the surface of the electric knife according to the present invention.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer and clearer, the present invention will be further described in detail below with reference to the accompanying drawings and examples.

As shown in Figure 1, a non-stick mucosal gastrointestinal hemostatic electrosurgical knife includes a control end 1 and an intestinal working end 2, and the control end 1 is connected to the intestinal working end 2; the control end 1 There is an electrification interface 12 on it; the intestinal working end 2 includes an intestinal working hose 21 and a retractable electrification core 22, and the electrification core 22 is installed in the intestinal working hose 21; the electrification core 22 is electrically connected with the energizing interface 12; the tail end of the energizing core 22 is provided with a smooth hemostatic head 220, and an anti-sticking mucous layer is arranged on the surface of the hemostatic head 220, and the The bottom layer 31, the conductive layer 32 and the anti-stick layer 33 on the surface of the 220 (as shown in FIG. 2) are firstly provided with the bottom layer 31 on the surface of the hemostatic head 220, and then the conductive layer of the nano-level columnar matrix is set on the surface of the bottom layer 31. layer 32 , and finally a release layer 33 is provided on the top surface of the nano-pillars of the conductive layer 32 .

Specifically, the primer layer 31 is made of an Ag material layer with a thickness of 3-8 μm; a transition layer of Ag material is arranged between the surface of the hemostatic head 220 and the conductive layer 32, and heat treatment at high temperature can make the hemostatic head 220 and Ag A thermally diffusing transition layer is formed between the material layers, between the Ag material layer and the conductive layer 32, thereby improving the bonding strength and thermal shock resistance; the setting of the Ag material layer can improve the bonding strength with the surface of the hemostatic head 220 , to improve the thermal shock resistance and electrical conductivity of the entire release film.

Specifically, the conductive layer 32 is a mixed layer of SiO2 and nano-Ag, and the thickness is 5-20µm. A layer of SiO2 and nano-Ag mixed layer with nano-column matrix is prepared on the surface of the hemostatic head 220 by the sol-gel method. A large number of air molecules are locked between the nano-columns of the mixed layer, so that the gap between the small intestine tissue and the electrosurgical knife is reduced. Most of the contact surface is air, which is equivalent to generating a layer of air cushion between the two, so as to achieve the purpose of anti-sticking; the mixed layer of SiO2 and nano-Ag can significantly reduce the resistivity of the entire anti-sticking film layer and reduce the entire anti-sticking layer when energized. The volume expansion caused by the heating of the mucosal layer itself makes the thermal expansion coefficient of the entire anti-adhesive mucosal layer and the hemostatic head 220 more matched.

Further, the SiO2 and nano-Ag mixed layer specifically includes the following components: tetraethyl orthosilicate (TEOS) 12-16%; water≤1%; HCL (hydrochloric acid) ≤1%; NH4OH ≤1%; Silver paste 1-5%; the rest is absolute ethanol.

By adding nano-silver paste with a particle size of 20-30nm to the precursor tetraethyl orthosilicate (TEOS), the SiO2 and nano-Ag mixed layer has good electrical conductivity and thermal conductivity, on the one hand, it satisfies the high frequency discharge of electrosurgery. On the other hand, it reduces the temperature difference between the electrotome substrate and the SiO2 and nano-Ag mixed layer, thereby improving the thermal shock resistance and high temperature resistance.

Specifically, the anti-adhesion layer 33 is made of Ag material layer or Au material layer, and the thickness is 0.5-2 μm. Because the thickness of the anti-adhesion layer 33 is too thin, the anti-adhesion effect cannot be achieved. If the thickness of the anti-adhesion layer 33 is too thick , the nano-pillars of the conductive layer 32 will be cut to peaks and valleys, and the micro-nano structures will be lost. The Au and Ag are inert metals, and their affinity with proteins is worse than that of SiO2. Electroplating a thin Ag material layer or Au material layer on the nano-rough surface of the SiO2 and nano-Ag mixed layer finally forms nano-roughness. Therefore, the Ag material layer or the Au material layer can prevent the hemostatic head 220 from adhering to the mucous membrane while hemostasis, thereby causing damage to the mucous membrane.

A preparation method of the above-mentioned anti-sticking film layer, specifically comprises the following steps:

A1: make the bottom layer 31;

A2: Prepare the conductive layer 32 of the nano-scale columnar matrix on the surface of the primer layer 31;

A3: A release layer 33 is provided on the top surface of the nano-pillars of the conductive layer 32 to obtain a release film layer.

Specifically, the conductive layer 32 is a mixed layer of SiO2 and nano-Ag in a nano-level columnar matrix, and the mixed layer of SiO2 and nano-Ag is prepared by a sol-gel method.

Further, the preparation method of the SiO2 and nano-Ag mixed layer includes the following steps:

a1: Slowly add tetraethyl orthosilicate (TEOS) dropwise to water, hydrochloric acid, NH4OH and absolute ethanol to form the precursor tetraethyl silicate;

a2: adding the nano-silver paste to the precursor tetraethyl silicate to obtain a mixed solution;

a3: The mixed solution is fully stirred and fully dispersed by ultrasonic waves to obtain a mixed wet gel of SiO2 and nano-Ag.

Wherein, the particle size of the nano-silver paste is 20-30 nm.

Wherein, in described step a2, the volume ratio of nano Ag is 5-20%.

A method for disposing the above-mentioned anti-sticking film layer on the surface of an electric knife, specifically comprising the following steps:

B1: Cover the surface of the entire hemostatic head 220 with the primer layer 31;

B2: covering the conductive layer 32 of the nanoscale columnar matrix on the entire surface of the bottom layer 31;

B3: The primer layer 31 and the conductive layer 32 on the surface of the hemostatic head 220 are baked at a high temperature of 200-500° C. for 2-4 hours. The general baking process of the SiO2 film is 120-200°C for 0.5-1 hour. In this technical solution, a high temperature of 200-500°C is used to bake the bottom layer 31 and the conductive layer 32 for 2-4 hours, so that each interface (hemostatic head) is baked for 2-4 hours. 220 surface-Ag material layer, Ag material layer-SiO2 and nano-Ag mixed layer) are thermally diffused with each other to form a significant transition layer, which effectively improves the bonding strength and thermal shock resistance of the anti-adhesive film layer and the surface of the hemostatic head 220.

B4: Cover the top surface of the nano-pillars of the conductive layer 32 with the release layer 33 .

The technical scheme now enumerates the following examples to illustrate:

Example 1

Bottom layer 31: Ag material layer with a thickness of 3µm.

Conductive layer 32: a mixed layer of SiO2 and nano-Ag, with a thickness of 20 µm; the components of the mixed layer of SiO2 and nano-Ag are as follows: tetraethyl orthosilicate (TEOS) 12%; water 1%; HCL 1%; NH4OH 1% ; Nano silver paste 1%; the rest is absolute ethanol.

Release layer 33: Ag material layer, thickness 0.5µm.

The preparation of the SiO2 and nano-Ag mixed layer: 12% tetraethyl orthosilicate (TEOS) was slowly added dropwise to 1% water, 1% hydrochloric acid, 1% NH4OH and absolute ethanol to form the precursor tetraethyl silicate. ethyl ester; adding 1% nano-silver paste to the precursor tetraethyl silicate to obtain a mixed solution; fully stirring the mixed solution and dispersing by ultrasonic to obtain a mixed wet gel of SiO2 and nano-Ag. Wherein, the particle size of the nano-silver paste is 20 nm; in the step S2, the volume ratio of the nano-Ag is 5 μm.

Set the anti-adhesion film layer on the surface of the electrosurgical knife: electroplate the Ag material layer on the surface of the entire hemostatic head 220 with a thickness of 3 µm; coat the nano-scale columnar matrix of SiO2 and nano-Ag mixed layer on the entire surface of the Ag material layer, The thickness is 20µm; then it is baked at a high temperature of 200℃ for 4 hours; the Ag material layer is electroplated on the top surface of the nanopillars of the SiO2 and nano-Ag mixed layer with a thickness of 0.5µm.

Example 2

Bottom layer 31: Ag material layer with a thickness of 8µm.

Conductive layer 32: a mixed layer of SiO2 and nano-Ag, with a thickness of 5 µm; the components of the mixed layer of SiO2 and nano-Ag are as follows: tetraethyl orthosilicate (TEOS) 16%; water 0.5%; HCL 0.5%; NH4OH 0.5% ; Nano silver paste 5%; the rest is absolute ethanol.

Release layer 33: Au material layer with a thickness of 1 µm.

The preparation of the SiO2 and nano-Ag mixed layer: 16% tetraethyl orthosilicate (TEOS) was slowly added dropwise to 0.5% water, 0.5% hydrochloric acid, 0.5% NH4OH and absolute ethanol to form the precursor tetraethyl silicate. ethyl ester; adding 5% nano-silver paste to the precursor tetraethyl silicate to obtain a mixed solution; fully stirring the mixed solution and dispersing by ultrasonic to obtain a mixed wet gel of SiO2 and nano-Ag. Wherein, the particle size of the nano-silver paste is 30 nm; in the step S2, the volume ratio of the nano-Ag is 20 μm.

Set the anti-adhesion film layer on the surface of the electrosurgical knife: electroplate the Ag material layer on the entire surface of the hemostatic head 220 with a thickness of 8 µm; coat the nano-scale columnar matrix of SiO2 and nano-Ag mixed layer on the entire surface of the Ag material layer, The thickness is 5µm; then it is baked at a high temperature of 500 °C for 2 hours; the Ag material layer is electroplated on the top surface of the nanopillars of the SiO2 and nano-Ag mixed layer with a thickness of 1µm.

Example 3

Bottom layer 31: Ag material layer with a thickness of 5µm.

Conductive layer 32: a mixed layer of SiO2 and nano-Ag, with a thickness of 15µm; the components of the mixed layer of SiO2 and nano-Ag are as follows: tetraethyl orthosilicate (TEOS) 16%; water 0.5%; HCL 0.5%; NH4OH 0.5% ; Nano silver paste 5%; the rest is absolute ethanol.

Release layer 33: Au material layer, thickness 0.8µm.

The preparation of the SiO2 and nano-Ag mixed layer: 14% tetraethyl orthosilicate (TEOS) was slowly added dropwise to 0.8% water, 0.8% hydrochloric acid, 0.8% NH4OH and absolute ethanol to form the precursor tetraethyl silicate. ethyl ester; adding 3% nano-silver paste to the precursor tetraethyl silicate to obtain a mixed solution; fully stirring the mixed solution and dispersing by ultrasonic to obtain a mixed wet gel of SiO2 and nano-Ag. Wherein, the particle size of the nano-silver paste is 25 nm; in the step S2, the volume ratio of the nano-Ag is 15 μm.

Set the anti-adhesion film layer on the surface of the electrosurgical knife: electroplate the Ag material layer on the entire surface of the hemostatic head 220 with a thickness of 5 µm; coat the nano-scale columnar matrix SiO2 and nano-Ag mixed layer on the entire surface of the Ag material layer, The thickness is 15µm; then it is baked at a high temperature of 350 °C for 3 hours; the Ag material layer is electroplated on the top surface of the nanopillars of the SiO2 and nano-Ag mixed layer with a thickness of 0.8µm.

After carrying out the resistivity test, anti-oxidation test, thermal shock test and anti-adhesion decay test of the electrosurgical knife provided with the anti-sticking film layer of Example 1-3 respectively, it can be seen that the above-mentioned anti-sticking film layer has low resistivity; Resistant to high temperature of 800 °C, the anti-adhesive film layer does not fall off and is anti-oxidative; after 30-800 °C thermal shock test, 50-100 thermal shock tests, the anti-adhesive film layer does not fall off; the anti-adhesive film layer has very little anti-adhesive attenuation .

In this technical solution, a primer layer 31, a conductive film layer 32 and an anti-stick layer 33 are sequentially arranged on the surface of the electro-knife base body, the primer layer 31 is an Ag layer, the conductive film layer 32 is a mixed layer of SiO2 and Ag, and the anti-stick layer 33 It is Au or Ag film layer; the purpose of setting the bottom layer 31 is to improve the bonding strength with the electrosurgery substrate, and improve the thermal shock resistance and electrical conductivity of the entire anti-adhesive film layer; setting the conductive film layer 32 can significantly reduce the entire anti-stick film layer. It reduces the volume expansion caused by the heating of the entire anti-adhesive film itself when energized, so that the thermal expansion coefficient of the entire anti-adhesive film and the electrosurgical base is more matched; the anti-adhesive layer 33 is provided to prevent At the same time of hemostasis, it adheres to the mucous membrane, causing damage to the mucous membrane; a layer of SiO2 and Ag mixed layer with nano-column matrix is prepared on the electrosurgical knife. Most of the contact surface with the electric knife is air, which is equivalent to generating a layer of air cushion between the two, so as to achieve the purpose of anti-sticking; The layer 33 not only achieves the purpose of the electrosurgical knife to conduct electricity to stop bleeding, but also ensures that the electrosurgical knife will not adhere to the mucous membranes, avoid damage to the mucous membranes, and ensure the hemostasis effect.

It should be understood that the application of the present invention is not limited to the above examples. For those of ordinary skill in the art, improvements or transformations can be made according to the above descriptions, and all these improvements and transformations should belong to the protection scope of the appended claims of the present invention.

Claims (8)

1. The preparation method of the anti-sticking film layer on the surface of the electrotome is characterized in that the prepared anti-sticking film layer is applied to a high-frequency electrotome and specifically comprises the following steps:

a1: preparing a bottoming layer;

a2: preparing a conductive layer of a nano-scale columnar matrix on the surface of the priming layer;

a3: arranging an anti-sticking layer on the top end surface of the nano column of the conducting layer to prepare an anti-sticking film layer;

the conductive layer is made of SiO with a nano-scale columnar matrix₂And a nano Ag mixed layer; the SiO₂The raw materials of the mixed layer with the nano Ag comprise the following components: 12-16% of tetraethyl orthosilicate; water is less than or equal to 1 percent; HCL is less than or equal to 1 percent; NH4OH is less than or equal to 1 percent; 1-5% of nano silver paste; the balance of absolute ethyl alcohol.

2. The method for preparing the surface anti-sticking film layer of the electrotome according to claim 1, wherein the primer layer is made of an Ag material layer.

3. The method for preparing the anti-sticking film layer on the surface of the electrotome according to claim 1, wherein the anti-sticking layer is made of an Ag material layer or an Au material layer.

4. The method for preparing the surface anti-sticking film layer of the electrotome according to claim 1, wherein the SiO is₂The mixed layer with the nano Ag is prepared by a sol-gel method.

5. The method for preparing the electrotome surface anti-sticking film layer according to claim 4, wherein the method for preparing the SiO2 and nano Ag mixed layer comprises the following steps:

a 1: slowly and dropwise adding tetraethyl orthosilicate into water, hydrochloric acid, NH4OH and absolute ethyl alcohol to form a precursor tetraethyl silicate;

a 2: adding nano silver paste into a precursor tetraethyl silicate to obtain a mixed solution;

a 3: and fully stirring the mixed solution, and performing ultrasonic dispersion to obtain the wet mixed gel of SiO2 and nano Ag.

6. The method for preparing the electrotome surface anti-sticking film layer according to claim 5, wherein the particle size of the nano silver paste is 20-30 nm.

7. The method for preparing the anti-sticking film layer on the electrotome surface according to claim 5, wherein the volume ratio of the nano silver in the nano silver paste is 5-20%.

8. The method for preparing the anti-sticking film layer on the surface of the electrotome according to claim 1, wherein a primer layer is firstly electroplated on the surface of the hemostatic tip, then a conductive layer of a nano-scale columnar matrix is prepared on the surface of the primer layer by a sol-gel method, and finally an anti-sticking layer is electroplated on the top end surface of the nano-column of the conductive layer.

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