CN110075151A - A kind of concocting method for the Rhizoma Atractylodis Macrocephalae being exclusively used in protection stomach lining - Google Patents

A kind of concocting method for the Rhizoma Atractylodis Macrocephalae being exclusively used in protection stomach lining Download PDF

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CN110075151A
CN110075151A CN201910383409.9A CN201910383409A CN110075151A CN 110075151 A CN110075151 A CN 110075151A CN 201910383409 A CN201910383409 A CN 201910383409A CN 110075151 A CN110075151 A CN 110075151A
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rhizoma atractylodis
atractylodis macrocephalae
milk
cow
fermentation
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易延逵
张璐
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Southern Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/17Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting

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Abstract

The present invention relates to a kind of concocting method of Rhizoma Atractylodis Macrocephalae for being exclusively used in protection stomach lining, which is comprised the steps of: (1) taking fermentation cow's milk, 30%~70% water is added in mass ratio, mixes, must ferment cow's milk dilution;(2) atractylodes slice of net system is taken, 10%~20% fermentation cow's milk dilution is added in mass ratio, mixes thoroughly, bored profit to fermentation cow's milk is sufficiently exhausted;(3) atractylodes slice handled through step (2) is placed in toast utensil, it is dry under the conditions of 50~70 DEG C, it takes out rapidly, cools, weed out clast.The Rhizoma Atractylodis Macrocephalae that this method is processed is remarkably improved the effect of protection stomach lining.

Description

A kind of concocting method for the Rhizoma Atractylodis Macrocephalae being exclusively used in protection stomach lining
Invention field
The present invention relates to the processing technologys of tcm and herbal slice, and in particular to Chinese medicine Rhizoma Atractylodis Macrocephalae concocting method.
Background technique
Rhizoma Atractylodis Macrocephalae is the dry rhizome of compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Winter lower part Excavation when leaf is withered and yellow, upper leaf becomes fragile removes silt, dries or dry, then remove fibrous root.Bitter, sweet, warm.Returns spleen, stomach meridian. Function strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, movement of the foetus It is uneasy.
Chinese medicine preparation is a feature of middle medical drugs and a big characteristic of traditional Chinese medicine and pharmacy.Chinese medicine due to complicated component, And mostly crude drug, many medicinal materials must be handled before using according to the state of an illness and actual needs, the processing of Yao Jinhang distinct methods; Meanwhile the purpose of Chinese medicine preparation be it is various, often a kind of concocting method or a variety of process a kind of drug while can have The purpose of several respects.The main processed product of Rhizoma Atractylodis Macrocephalae has net Rhizoma Atractylodis Macrocephalae, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, stir-baked RHIZOMA ATRACTYLODIS MACROCEPHALAE with soil, water in which rice has been washed Rhizoma Atractylodis Macrocephalae." Chinese Pharmacopoeia " (version in 2015) and " science of Chinese drug processing " (Beijing Gong Qianfeng science of Chinese drug processing: China Traditional Chinese Medicine Publishing House [M] .2016.) etc. In recorded net Rhizoma Atractylodis Macrocephalae, stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran and stir-baked RHIZOMA ATRACTYLODIS MACROCEPHALAE with soil.Ancient times Rhizoma Atractylodis Macrocephalae concocting method there are about more than 50 kinds, more than 20 kinds of application accessory, About the record of milk toast, it is detected in " human milk moistens it, makes its property " (" covering bamboo fish trap "), i.e., is processed using human milk, still Auxiliary material used in the record is human milk, and source is difficult, also without specific concocting method, thus application below seldom until modern age no longer It uses.
The patent of invention that Chinese medicine preparation involved in Chinese patent database processs method is 40 about nearly, and involved mainly having is each The toast method etc. of kind drug, be related to Rhizoma Atractylodis Macrocephalae processing has nearly 20 kinds, wherein the representative are three.One is open Number CN106924389A is a kind of processed products of Rhizoma Atractylodis Macrocephalae and application thereof, and which disclose a kind of processed products of Rhizoma Atractylodis Macrocephalae, it is by following The bulk pharmaceutical chemicals of weight proportion are through processing: 1~10 part of the dried immature fruit of citron orange, 100 parts of Rhizoma Atractylodis Macrocephalae.Effect experiment shows that dried immature fruit of citron orange system of the present invention is white Art has good invigorating the spleen effect, and significant effect is better than raw Rhizoma Atractylodis Macrocephalae;On the other hand, the dry property of processed product substantially reduces, for system The drug or health care product that standby invigorating the spleen is dispelled dry provide a kind of new selection.The second is Publication No. CN103638084A is about white Art reformed processing method, the present invention relates to a kind of Rhizoma Atractylodis Macrocephalae reformed processing methods for subtracting ketone and increasing ester, belong to Chinese medicine preparation technical field.This Kind Rhizoma Atractylodis Macrocephalae reformed processing method weighs the life bighead atractylodes rhizome piece for cleaning, removing product of damaging by worms and go mouldy in mass, and first plus Poria cocos juice is in 20 DEG C~30 DEG C at a temperature of, it is closed impregnate 4~16 hours, be placed in frying container, heated with mild fire, fried dry, taking-up cools down;Again plus Edible hydrogen peroxide is closed to impregnate 6~30 hours at a temperature of 10 DEG C~60 DEG C, takes out, dries;Finally plus polygonatum odoratum juice, in 20 DEG C~30 DEG C, closed to impregnate 4~16 hours, airing is placed in steamer and is steamed to slightly dry, and surface is brown color, it takes out, airing, Obtain atractylodes slice finished product.The method proves that prepared slice quality is stablized, securely and reliably, through content by multiple batches of laboratory scale-up Measurement, more raw Rhizoma Atractylodis Macrocephalae, traditional stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran can more effectively achieve the purpose that " subtract ketone and increase ester ", while the pharmacological results table Bright, decoction Rhizoma Atractylodis Macrocephalae, better than raw Rhizoma Atractylodis Macrocephalae and traditional stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran, better plays the effect of " synergy " in terms of function of invigorating spleen.Its Third is that a kind of pure milk prepared maltiflower knotweed of Publication No. CN101455725A.The present invention discloses a kind of pure milk prepared maltiflower knotweed, by fresh The fleece-flower root is aided with the kinds of traditional Chinese medicines material such as Poria cocos, radix achyranthis bidentatae, semen sojae atricolor, glutinous rehmannia, Radix Angelicae Sinensis, Semen Cuscutae, fructus lycii, psoralea corylifolia, Semen sesami nigrum through more It is secondary to steam, after dew, solarization system, then be made with plain chocolate processing.It is reasonable above-mentioned that pure milk prepared maltiflower knotweed by the fresh fleece-flower root is aided with proportion Chinese medicine carry out it is multiple steam, reveal system, shine system after, then with plain chocolate processes and is made, during processing, the fleece-flower root and Medicinal health effect of prepared fleece flower root is greatly improved in above-mentioned Chinese medicine, plain chocolate etc. " mutual reinforcement between mutually makes ", liver protection support kidney, Adjust that endocrine, nourish and beautify skin, enhancing are immune etc. to have good maintenance therapeutic effect;And impregnated using plain chocolate, it can Improve the mouthfeel of prepared fleece flower root finished product.
On the one hand above-mentioned concocting method can enrich the kind of Chinese medicine preparation product, still further aspect also excavates Chinese medicine preparation Essence, the technological parameter of processing is standardized, guarantees that the uniform specification of the prepared slices of Chinese crude drugs, standard are consistent, it is curative for effect.
But the patent application for being related to the processing of Chinese medicine Rhizoma Atractylodis Macrocephalae at present is less, therefore provides a kind of new Rhizoma Atractylodis Macrocephalae processing side Method is of great significance the effect of Rhizoma Atractylodis Macrocephalae protection stomach lining with improving.
Summary of the invention
Technical problem to be solved by the invention is to provide a kind of concocting methods of Rhizoma Atractylodis Macrocephalae for being exclusively used in protection stomach lining, should The Rhizoma Atractylodis Macrocephalae that method is processed is remarkably improved the effect of protection stomach lining.
The scheme that the present invention solves above-mentioned technical problem is:
A kind of concocting method for the Rhizoma Atractylodis Macrocephalae being exclusively used in protection stomach lining, the concocting method comprise the steps of:
(1) fermentation cow's milk is taken, 30%~70% water is added in mass ratio, mixes, must ferment cow's milk dilution;
(2) atractylodes slice of net system is taken, 10%~20% fermentation cow's milk dilution is added in mass ratio, mixes thoroughly, bored profit It is sufficiently exhausted to fermentation cow's milk;
(3) atractylodes slice handled through step (2) is placed in toast utensil, it is dry under the conditions of 50~70 DEG C, rapidly It takes out, cools, weed out clast.
In above scheme, the fermentation cow's milk is remembered according in GB19302-2010 national food safety standard acidified milk The fermentation cow's milk of acidified milk method and the quality requirement preparation of load.
In above scheme, the toast utensil is drying box.
The Rhizoma Atractylodis Macrocephalae that concocting method of the present invention processes not only protects the significant effect of stomach lining to be better than traditional concocting method Processed product, and can guarantee that the color of medicine materical crude slice is uniform in character, quality is stablized.
The effect that will prove that the present invention has by testing below.
One, defencive function comparative study of the different processed products of Rhizoma Atractylodis Macrocephalae to gastric mucosa
1, equipment
Cimitidine Tablets are produced by Chengdu Jinhua Pharmaceutical Co., Ltd, 0.2g × 100 piece, lot number: 130405.Take west Rice replaces fourth piece 20, is added in 100ml distilled water, sufficiently dissolves, 4g/100ml solution is made, it is spare to be put into 4 DEG C of refrigerators.It is anti- Only drug effect reduces, and tests drug solution used with with matching.Ethanol solution, 10% formalin, 10% chloraldurate are molten Liquid, 0.05mmol/L hydrochloric acid solution are that analysis is pure.DAB colour reagent box is purchased from Wuhan Jing Mei bioengineering Co., Ltd.It is high Fast refrigerated centrifuge (HERMLE, Germany), 722 type spectrophotometers (Shanghai, China)
The atractylodes slice of net system: being purchased from prepared slices of Chinese crude drugs factory, Guangdong Province's medicinal material company (lot number: B4218712, the place of production: Anhui), Compositae plant Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz. is accredited as through Nanfang Medical Univ associate professor Liu Chuanming Dry rhizome.
Stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran: " Chinese Pharmacopoeia " (version in 2015) and " science of Chinese drug processing " (Beijing Gong Qianfeng science of Chinese drug processing: in Traditional Chinese medicine publishing house, state [M] .2016.) etc. in the Rhizoma Atractylodis Macrocephalae bran recorded fry method and processed.
Stir-baked RHIZOMA ATRACTYLODIS MACROCEPHALAE with soil: " Chinese Pharmacopoeia " (version in 2015) and " science of Chinese drug processing " (Beijing Gong Qianfeng science of Chinese drug processing: in Traditional Chinese medicine publishing house, state [M] .2016.) etc. in the Rhizoma Atractylodis Macrocephalae soil recorded fry method and processed.
Human milk processs Rhizoma Atractylodis Macrocephalae: referring to the processing of following 2 methods of embodiment, specific concocting method is as follows: the Rhizoma Atractylodis Macrocephalae of net system being taken to drink Piece is mixed thoroughly, bored profit is sufficiently exhausted to human milk by weight the human milk for being added 15%;It is placed in toast utensil, is done under temperature 60 C It is dry, it takes out rapidly, cools, weed out clast, obtain the human milk toast Rhizoma Atractylodis Macrocephalae.
Ferment cow's milk toast Rhizoma Atractylodis Macrocephalae (Rhizoma Atractylodis Macrocephalae of protection stomach lining i.e. of the present invention): for the Rhizoma Atractylodis Macrocephalae of following embodiments 2 preparation.
Above 5 kinds of processed products of Rhizoma Atractylodis Macrocephalae extract according to traditional Chinese herbal decoction preparation method, are concentrated into quite every ml medical fluid net system containing 1g Atractylodes slice.
2, experimental animal:
SPF grades of adult healthy ICR mouse, are provided, quality certification number totally by Nanfang Medical Univ's Experimental Animal Center by 80 The animal feeding quality certification: the Guangdong scxk 2011-0015 cures dynamic word 2002009 in Guangdong.All each group mouse divide equally cage adaptive feeding One week, mouse freely ingested, drinks water during the experiment, and standard particle feed is given once daily in raising rat.Germicidal efficacy room is to open Formula is put, room temperature is controlled at 22-25 DEG C, and the conditions such as illumination, noise, ventilation control within the specified scope, and daily timing is cleaned.
3, dose design and grouping
Experimental animal is randomly divided into 8 groups, each processed products of Rhizoma Atractylodis Macrocephalae group dosage is that 6-12g is calculated by people's usual amounts, is set as Dosage, using general dose lonvestion method, referring specifically to: the Beijing Qi Chen herbal pharmacology research methodology: people's health goes out Version society [M] .2006:116).Specific grouping are as follows:
A group: normal group, 10 mouse use physiological saline stomach-filling.
B group: model group, 10 mouse use physiological saline stomach-filling.
C group: net Rhizoma Atractylodis Macrocephalae group, 10 mouse, stomach-filling 12.5ml/kg.
D group: stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran group, 10 mouse, stomach-filling 12.5ml/kg.
E group: stir-baked RHIZOMA ATRACTYLODIS MACROCEPHALAE with soil group, 10 mouse, stomach-filling 12.5ml/kg.
F group: human milk processs Rhizoma Atractylodis Macrocephalae group, 10 mouse, stomach-filling 12.5ml/kg.
G group: fermentation cow's milk processs Rhizoma Atractylodis Macrocephalae group, 10 mouse, stomach-filling 12.5ml/kg.
H group: Cimetidine group, 10 mouse, stomach-filling 0.02g/kg.
4 experimental methods
The continuous 7d gastric infusion of mouse, 1 time/d, the 6th day administration after fasting for 24 hours, free water.After last gastric infusion The equal stomach-filling dehydrated alcohol 0.2ml/ of all animals of 30min is only.Mouse takes off neck and puts to death, and ligatures cardia and pylorus, injects into gastral cavity Formaldehyde 2ml, fixed 10min, cuts off along greater curvature, checks ulcer index.Wherein lesion length < 1mm is 1 point, 1mm≤lesion Length < 2mm is 2 points, and 2mm≤lesion length < 3mm is 3 points, and 3mm≤lesion length < 4mm is 4 points, if lesion is longer than 4mm, It is then segmented score, when lesion is wider than 2mm, score is multiplied by 2, finally using full stomach Lesion score summation as the animal mucosal lesion Index (lesion index, LI).
5 results
Test result shows normally to organize Mouse Gastric Mucous Membrane color Exocarpium Citri Rubrum, and surface is smooth, and wrinkle wall is obvious, and surface attachment is more Mucus has no that damage sexually revises;Model group Mouse Gastric Mucous Membrane is congested, it is seen that different degrees of ulcer is dispersed in the gruel of point (line, piece) shape Rotten, blutpunkte (band), skin surface have coffee-like tongue fur to adhere to, and ulcer margin hyperemia, oedema, ulcer index is maximum, with normal group Compare, difference has significant difference (P < 0.01), prompts modeling success.Positive drug Cimetidine group can reduce the damage of gastric mucosa Index has extremely significant sex differernce (P < 0.01) compared with model group.Compared with model group, each group has aobvious each processed products of Rhizoma Atractylodis Macrocephalae group It writes sex differernce (P < 0.05);Cow's milk toast Rhizoma Atractylodis Macrocephalae group ferment compared with model group, has extremely significant sex differernce (P < 0.01), with net Rhizoma Atractylodis Macrocephalae Group (i.e. the Rhizoma Atractylodis Macrocephalae of net system), which compares, significant difference (P < 0.05), compared with remaining each processed products of Rhizoma Atractylodis Macrocephalae group, has conspicuousness poor Different (P < 0.05), test result illustrate that fermentation cow's milk toast Rhizoma Atractylodis Macrocephalae is significantly better than remaining each Rhizoma Atractylodis Macrocephalae big gun in terms of protecting stomach lining effect Product.It the results are shown in Table 1.
Influence of each processed product of 1 Rhizoma Atractylodis Macrocephalae of table to mucosal lesion
Compared with model group: P < 0.01 * P < 0.05, * *;Compared with normal group: #P < 0.05, ##P < 0.01;With fermentation ox Cream toast Rhizoma Atractylodis Macrocephalae group compares: P < 0.01 ※ P < 0.05, ※ ※
Specific embodiment
Example 1
The cow's milk that ferments processs atractylodes slice preparation method:
(1) it prepares fermentation cow's milk: taking fermentation cow's milk, the water of fermentation milk quality 30% is added, mix;
(2) it mixes exhaustion thoroughly: taking net Rhizoma Atractylodis Macrocephalae (i.e. the Rhizoma Atractylodis Macrocephalae of net system) that 10% step (1) preparation of suitable Rhizoma Atractylodis Macrocephalae quality is added Ferment cow's milk, mixes thoroughly, and bored profit to fermentation cow's milk is sufficiently exhausted;
(3) heating toast system: the above-mentioned net Rhizoma Atractylodis Macrocephalae for absorbing fermentation cow's milk is put in a drying box, 50 DEG C of heating temperature, toast System is dry to processed products of Rhizoma Atractylodis Macrocephalae, takes out rapidly, cools, weed out clast, packs, is put in storage to obtain the final product.
Example 2
The cow's milk that ferments processs atractylodes slice preparation method:
(1) it prepares fermentation cow's milk: taking fermentation cow's milk, the water of fermentation milk quality 50% is added, mix;
(2) it mixes exhaustion thoroughly: taking net Rhizoma Atractylodis Macrocephalae that the fermentation cow's milk that 15% step (1) of suitable Rhizoma Atractylodis Macrocephalae quality is prepared is added, mix thoroughly, Bored profit to fermentation cow's milk is sufficiently exhausted;
(3) heating toast system: the above-mentioned net Rhizoma Atractylodis Macrocephalae for absorbing fermentation cow's milk is put in a drying box, 60 DEG C of heating temperature, toast System is dry to processed products of Rhizoma Atractylodis Macrocephalae, takes out rapidly, cools, weed out clast, packs, is put in storage to obtain the final product.
Example 3
The cow's milk that ferments processs atractylodes slice preparation method:
(1) it prepares fermentation cow's milk: taking fermentation cow's milk, the water of fermentation milk quality 70% is added, mix;
(2) it mixes exhaustion thoroughly: taking net Rhizoma Atractylodis Macrocephalae that the fermentation cow's milk that 20% step (1) of suitable Rhizoma Atractylodis Macrocephalae quality is prepared is added, mix thoroughly, Bored profit to fermentation cow's milk is sufficiently exhausted;
(3) heating toast system: the above-mentioned net Rhizoma Atractylodis Macrocephalae for absorbing fermentation cow's milk is put in a drying box, 70 DEG C of heating temperature, toast System is dry to processed products of Rhizoma Atractylodis Macrocephalae, takes out rapidly, cools, weed out clast, packs, is put in storage to obtain the final product.
Example 4
The cow's milk that ferments processs atractylodes slice preparation method:
(1) it prepares fermentation cow's milk: taking fermentation cow's milk, the water of fermentation milk quality 40% is added, mix;
(2) it mixes exhaustion thoroughly: taking net Rhizoma Atractylodis Macrocephalae that the fermentation cow's milk that 15% step (1) of suitable Rhizoma Atractylodis Macrocephalae quality is prepared is added, mix thoroughly, Bored profit to fermentation cow's milk is sufficiently exhausted;
(3) heating toast system: the above-mentioned net Rhizoma Atractylodis Macrocephalae for absorbing fermentation cow's milk is put in a drying box, 60 DEG C of heating temperature, toast System is dry to processed products of Rhizoma Atractylodis Macrocephalae, takes out rapidly, cools, weed out clast, packs, is put in storage to obtain the final product.

Claims (2)

1. a kind of concocting method for the Rhizoma Atractylodis Macrocephalae for being exclusively used in protection stomach lining, the concocting method comprise the steps of:
(1) fermentation cow's milk is taken, 30%~70% water is added in mass ratio, mixes, must ferment cow's milk dilution;
(2) atractylodes slice of net system is taken, 10%~20% fermentation cow's milk dilution is added in mass ratio, mixes thoroughly, bored profit to hair Ferment cow's milk is sufficiently exhausted;
(3) atractylodes slice handled through step (2) is placed in toast utensil, it is dry under the conditions of 50~70 DEG C, it takes out rapidly, It cools, weeds out clast.
2. a kind of concocting method of Rhizoma Atractylodis Macrocephalae for being exclusively used in protection stomach lining according to claim 1, which is characterized in that step (1) in, the additional amount of the water is 50%;In step (2), the additional amount of the fermentation cow's milk dilution is 15%;Step (3) In, the temperature of the drying is 60 DEG C.
CN201910383409.9A 2019-05-09 2019-05-09 A kind of concocting method for the Rhizoma Atractylodis Macrocephalae being exclusively used in protection stomach lining Pending CN110075151A (en)

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