CN110075061A - A kind of Ni Lapani oral solution and preparation method thereof - Google Patents
A kind of Ni Lapani oral solution and preparation method thereof Download PDFInfo
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- CN110075061A CN110075061A CN201910189326.6A CN201910189326A CN110075061A CN 110075061 A CN110075061 A CN 110075061A CN 201910189326 A CN201910189326 A CN 201910189326A CN 110075061 A CN110075061 A CN 110075061A
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- lapani
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- oral
- diazepam
- bar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/24—Devices for supporting or handling bottles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
Abstract
The invention discloses a kind of Ni Lapani oral solutions and preparation method thereof, belong to drug production field, Ni Lapani oral solution includes the component of following parts by weight: 10-20 parts of Ni Lapani, 4-8 parts of diazepam, 3-6 parts of malt selenium, 3-6 parts of vitamin E, 20-40 parts of filler, 3-6 parts of rapeseed oil, 4-8 parts of acetone, 130-150 parts of deionized water；Preparation method is first to respectively correspond diazepam and vitamin E to be dissolved in acetone and rapeseed oil, Ni Lapani, deionized water and partially filled agent are uniformly mixed, then diazepam solution and vitamin E solution obtained is added, add malt selenium and remaining filler, through filling, instantaneously sterilising, mounted box to get Ni Lapani oral solution after being uniformly mixed.Ni Lapani oral solution of the invention can promote Ni Lapani to play anticancer therapeutic but also reduce its adverse reaction.
Description
Technical field
The present invention relates to drug production field, it is specifically related to a kind of Ni Lapani oral solution and preparation method thereof.
Background technique
Ni Lapani (Niraparib) is a kind of oral Poly ADP-ribose polymerase (PARP) inhibitor, mainly for
It is the cancer of BRCA1/2 gene mutation, exploitation is used for oophoroma and breast cancer.Ni Lapani inhibits cell to repair DNA damage
It is multiple, for the cancer cell with BRCA gene mutation, if PARP activity is further suppressed, when these cell divisions
A large amount of DNA damages will be generated, cancer cell death is caused.The chemical name of Ni Lapa is 2- [4- ((3S) -3- piperidyl) benzene
Base] -2H- indazole -7- formamide, it is developed by MSD Corp., after transfer biotech company, U.S. Tesaro, the public affairs
Department announces the three phase clinical datas that Ni Lapani is directed to advanced ovarian cancer, presents extremely good curative effect.
Ni Lapani capsule went through to list in the U.S. in 2017, and manufacturer is salol company, Thailand, the U.S..Ni Lapa
Most common 1 grade or 2 grades of the adverse reaction of Buddhist nun is haematics toxicity, including anaemia, thrombopenia and neutrophil
Reduce disease；Gastrointestinal discomfort, including nausea, apositia, constipation and vomiting；It is tired etc..The plasma protein binding rate of Ni Lapani
Be 83%, after taking, most of drug is in conjunction with plasma protein so that the drug concentration of sequestered is lower, drug effect play compared with
Slowly.If wanting to promote drug effect by the drug concentration for the sequestered for improving Ni Lapani, the side effect of drug can also increase therewith,
Promote the generation of adverse reaction.Currently, can promote that Ni Lapani plays anticancer therapeutic but also to reduce its bad there are no one kind
The drug of reaction.
Summary of the invention
1. technical problems to be solved
The technical problem to be solved in the present invention is that providing a kind of Ni Lapani oral solution and preparation method thereof, the Ni Lapa
Buddhist nun's oral solution can promote Ni Lapani to play anticancer therapeutic but also reduce its adverse reaction.
2. technical solution
To solve the above problems, the present invention adopts the following technical scheme that:
A kind of Ni Lapani oral solution, the component including following parts by weight:
10-20 parts of Ni Lapani；
4-8 parts of diazepam；
3-6 parts of malt selenium；
3-6 parts of vitamin E；
20-40 parts of filler；
3-6 parts of rapeseed oil；
4-8 parts of acetone；
130-150 parts of deionized water；
The filler includes sweetener, aromatic, mucilage.
Specifically, the sweetener is the composition of any one or more in protein sugar, xylitol and stevioside；
The aromatic is the group of any one or more in lemon extract, flavoring apple essence, peppermint oil and flavoring banana essence
Close object；
The mucilage is the group of any one or more in methylcellulose, sodium carboxymethylcellulose and sodium alginate
Close object.
The present invention also provides the preparation methods of above-mentioned Ni Lapani oral solution, include the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 500~800r/min, diazepam solution obtained in step (I) is first added, adds in step (I) and is made
Vitamin E solution, be eventually adding malt selenium and mucilage, stir evenly, be made drug miscible fluid；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), the mounted box after instantaneously sterilising, i.e.,
Get Ni Lapani oral solution.
Further, spitting for the 0.5% of all components quality is first added in above-mentioned steps (II) between addition vitamin E
Temperature.The emulsifiable rapeseed oil of tween, to promote the fusion of vitamin E solution.
Specifically, the technological parameter of instantaneously sterilising described in above-mentioned steps (III) are as follows: temperature is 100 DEG C, and pressure is
110kpa, sterilizing time 3s.
A kind of filling apparatus, structure are used when filling in the step of above-mentioned preparation method (III) are as follows:
The filling apparatus includes liquid reserve tank, bolus tube, injecting mechanism, conveyer belt, oral liquid bottle off-position mechanism and support
Frame, the bolus tube is set to liquid reserve tank side vertically, and liquid reserve tank side bottom close with bolus tube is connected to by suction tube, described
Bolus tube bottom is fixedly connected with the medicine-pouring pipe being vertically arranged, and the suction tube is equipped with the check valve opened towards bolus tube, note
Pencil is equipped with the check valve opened towards its lower port, and the conveyer belt is used to transport oral liquid bottle, and the oral liquid bottle stops
Position mechanism is set on conveyor width direction and is located at immediately below bolus tube, and support frame as described above includes being supported in liquid reserve tank bottom
Main supporting table and positioned at bolus tube backwards to the secondary supporting table of liquid reserve tank side, it is fixed between the main supporting table and secondary supporting table to connect
It is connected to the support plate one for being supported in bolus tube bottom, the support plate one is equipped with the port passed through for medicine-pouring pipe；
The injecting mechanism includes the piston head that in bolus tube and periphery is bonded with bolus tube inner wall, the piston head
It being fixed with to be vertically arranged and pass through at the top of bolus tube in the middle part of top surface and injects bar, the bar upper end of injecting is hinged with oscillating rod, and
Inject bar upper end side equipped at least two it is longitudinally-aligned be used to the hinge joint hinged with oscillating rod, the oscillating rod upper end is fixed
There is lantern ring, the lantern ring internal clearance formula is equipped with horizontally disposed push-pull rod, and shown push-pull rod both ends are respectively provided with a L shape
Bar, the L shape bar vertical portion are equipped with the regulating tank moved up and down for push-pull rod respective end；The injecting mechanism further includes
The horizontally disposed rotary electric machine of output shaft, the output axis connection retarder of the rotary electric machine, the retarder output end and one
The horizontal component coaxial-type of root L shape bar is connected, the end connection bearing one of the horizontal component of another L shape bar, and two " L "
Shape bar is symmetrical arranged about in the middle part of push-pull rod；The rotary electric machine bottom is equipped with the support plate two being connected in main supporting table, institute
Bearing one is stated to be fixedly attached in secondary supporting table；
Oral liquid bottle off-position mechanism includes two identical cylinders for being respectively arranged on conveyor width direction two sides
Platform, the cylindrical stage side equidistantly offer N number of holding tank through its own both ends of the surface, and N is the even number greater than 0, when
The corresponding holding tank of two of two cylindrical stages turns between two cylindrical stages and when opposite, and oral liquid bottle is just
It can be held between the two holding tanks；The rotation axis being vertically arranged is equipped at the cylindrical stage center, described in two
Fixing sleeve is equipped with intermeshing identical gear wheel in rotation axis, and the gear wheel is located at below conveyer belt, a rotation axis
On go back fixing sleeve be equipped be located at gear wheel below pinion gear, the pinion gear side be equipped with connection driving motor sliding tooth
It takes turns, spacing are equipped with the gear teeth engaged with pinion gear that N/2 sections of corresponding central angles are 360 °/N, and the wheel on the driving gear etc.
Linear distance between tooth ends and driving gear central point is equal to the half of pinion gear outer diameter；The driving motor bottom is equipped with
The supporting plate being connected in main supporting table and secondary supporting table, the rotation axis lower end is fastened on the bearing two on supporting plate；It is described
The time that sliding tooth wheel rotates 360 °/N is equal to the time of the output shaft rotation half-turn of retarder.
Further, it is equipped with and is connected in secondary supporting table above the bolus tube of the filling apparatus used in preparation method
Limit plate, the limit plate are equipped with just for injecting the limit hole that bar passes through.Limit hole cuff is injecting bar side, defines
Injecting bar can only move up and down, and satisfaction injects movement demand.
Further, at the hinge joint for injecting bar upper end of the filling apparatus used in preparation method and oscillating rod lower end
It is equipped with the through-hole one passed through for bolt one；Point of adjustment corresponding with the hinge joint for injecting bar upper end is equipped in the regulating tank,
The point of adjustment and push-pull rod both ends offer the through-hole two passed through for bolt two.It is hinged with oscillating rod by adjusting hinge joint
And bolt one is inserted into corresponding through-hole one, it with nut check, while adjusting point of adjustment and being connect with push-and-pull boom end, and by bolt
The two corresponding through-holes two of insertion can be adjusted with nut check and be injected the purpose that bar injects distance, implement easy to operate.
Further, the top side of the liquid reserve tank of the filling apparatus used in preparation method is equipped with feeding opening, described
Central axis is equipped with the agitating shaft at the top of it in liquid reserve tank, is uniformly fixed with multiple stirring rods on the agitating shaft, described
Agitating shaft upper end is fastened on the bearing three in support plate two, and agitating shaft lower end is fastened on the bearing of bottom in liquid reserve tank
Four, the agitating shaft upper end side is located at the part fixing sleeve above liquid reserve tank equipped with horizontally disposed bevel gear one, the deceleration
The output end fixing sleeve of device is equipped with and the bevel gear two engaged with bevel gear one that is vertically arranged.The output end of retarder rotates band
Dynamic bevel gear two rotates, then band dynamic bevel gear one rotates, to agitating shaft can be driven to rotate, at this point, stirring rod is in liquid reserve tank
It is interior to rotate the stirring action, it can be achieved that medical fluid, it may advantageously facilitate medical fluid and be uniformly dispersed, so as to promote oral solution quality.
3. beneficial effect
(1) contain Ni Lapani and diazepam in drug provided by the present invention.The plasma protein binding rate of diazepam is high
Up to 95%, and the plasma protein binding rate of Ni Lapani is 83%, and after both drugs take jointly, diazepam can be reduced Buddhist nun
Amount of the La Pani in conjunction with plasma protein achievees the purpose that enhance drug effect so that the drug concentration of sequestered increases.In addition, Buddhist nun
La Pani generally takes before sleeping, and can be relieved the adverse reactions bring sense of discomfort such as nauseous, tired；And diazepam is as a kind of
Neuroleptic agent has effects that antianxiety, calmness, hypnosis, and user can be promoted to enter sleep, thus ensure mitigation nausea,
Tired equal adverse reactions bring sense of discomfort, that is, can be relieved that " side effect of drug can also increase therewith, promote the hair of adverse reaction
It is raw " this problem.
(2) contain malt selenium and vitamin E in drug provided by the present invention.Malt selenium is turned into as one kind with antioxygen
Cancer-resisting substance can enhance the anticancer function of composition of medicine.In addition, malt selenium and vitamin E cooperation, can repair impaired thin
Born of the same parents stimulate the formation of immunoglobulin, promote stabilized leukocyte value, service hoisting leucocyte, blood platelet, while enhancing human body and exempting from
Epidemic disease power alleviates the adverse reactions such as nausea and vomiting, loss of appetite, out of strength.It can alleviate and take Ni Lapani bring blood platelet and subtract
Few disease, neutropenia and the adverse reactions such as nausea, anorexia, vomiting, tired.
(3) oral solution form is made in composition of medicine by the present invention, compared with than in tablet or capsule, the drug of oral solution form
The patient that is more convenient for takes.
(4) present invention uses a kind of special filling apparatus in the preparation process of drug comprising connects with liquid reserve tank
Logical bolus tube is equipped with piston head in bolus tube, and bar is injected in piston head connection, injects bar upper end connection oscillating rod, on oscillating rod
End wears push-pull rod, and push-pull rod is connected to L shape bar vertical portion backwards to the side of its lateral part, and push-pull rod can be around L shape
The rotation of bar lateral part center line, when push-pull rod hoists from lower to be rotated, can drive oscillating rod to move up；Work as push-pull rod
When rotating from high to lower, oscillating rod can be driven to move down.It injects bar and piston head is moved up and down with oscillating rod, it is real respectively
The suction action and perfusion movement of existing bolus tube, because of the cyclophysis of push-pull rod rotation, so that the distance moved every time is uniform
It causes, then the liquid volume of bolus tube suction and the liquid volume of perfusion are equal；Push-pull rod moves a cycle, and bolus tube completes a medicine
Liquid extracts and medicinal liquid filling is, it can be achieved that continuous operation, is convenient for control.
(5) filling apparatus of the invention includes the conveyer belt for transmitting oral liquid bottle and the mouth immediately below bolus tube
Fu Yeping off-position mechanism, oral liquid bottle off-position mechanism include two identical cylinders for being respectively arranged on conveyor width direction two sides
Shape platform, cylindrical stage side equidistantly offer N (N is greater than 0 even number) a holding tank through its own both ends of the surface, cylinder
Shape platform is rotated by sliding tooth wheel drive, and spacing are equipped with the gear teeth that N/2 sections of corresponding central angles are 360 °/N on the driving gear etc..
When two corresponding holding tanks of two cylindrical stages turn to the side of corresponding conveyer belt feed end, the two holding tanks are opened
Begin clamping oral liquid bottle, until holding tank is located between two cylindrical stages and when opposite, oral liquid bottle be just held in this two
Between a holding tank, at this point, the gear teeth on driving gear are detached from and engage with respective gears, cylindrical stage stalls therewith, driving
During moving gear continues to rotate 360 °/N, cylindrical stage cannot all be activated rotation, hold between two cylindrical stages
One oral liquid bottle, although transmission belt keeps continuous transmission, due to the blocking of respective clamp groove sidewall on cylindrical block, so that
Oral liquid bottle, which is stablized, to be located at immediately below medicine-pouring pipe, can prevent oral liquid bottle from toppling over, in order to which bolus tube carries out perfusion；Oral liquid bottle
Off-position mechanism is period intermittent movement to the positioning of oral liquid bottle, in the process for carrying out the positioning of an oral liquid bottle, is injected
Cylinder carries out extracting medical fluid movement, and sliding tooth wheel has rotated 360 °/N；In the time for waiting oral liquid bottle positioning next time, bolus tube
It is irrigated medical fluid movement, sliding tooth wheel has rotated 360 °/N, then oral liquid bottle positioning time and waiting time are equal, meet and push away
The time of cylinder aspiration medicinal liquid and perfusion solution equal situation is infused, serialization running is easy to implement.
(6) the bar upper end side of injecting of filling apparatus of the invention longitudinally-aligned is used to and oscillating rod is cut with scissors equipped at least two
The hinge joint connect, L shape bar vertical portion are equipped with the regulating tank moved up and down for push-pull rod respective end.Bar upper end is injected in selection
Different hinge joints and oscillating rod lower end are hinged, at this point, the height of oscillating rod upper end changes, change push-pull rod in adjustment tank
Interior position, fixed push-pull rod.After rotary electric machine driving rotation, the rotary motion trace of push-pull rod is formed by the radius of cylindrical curved surface
The distance that difference, i.e. push-pull rod move up and down changes, so that injecting, the distance that bar moves up and down is different, because bolus tube
Floor space is constant, and the dose being once perfused can be adjusted in the moving distance by changing piston head.Filling for different perfusion amounts
Medicine operation, although the moving distance of piston head, push-pull rod is different, rotary electric machine drives the time of push-pull rod rotation a cycle
Be it is constant, i.e., the time of aspiration medicinal liquid and the time of perfusion solution are all constant in bolus tube, to vary without oral
Residence time of the liquid bottle in filling process, and then it is not required to the drive control of adjustment oral liquid bottle off-position mechanism, it solves existing
Oral liquid bottle is necessarily adjusted the problem of the station residence time is perfused when adjusting perfusion amount in technology, and application value is higher.
To sum up, drug provided by the present invention can promote Ni Lapani play anticancer therapeutic again reduce its it is bad instead
It answers；The operational effect of the filling apparatus used in preparation method is preferable, and operation is more convenient, and application value is higher.
Detailed description of the invention
Fig. 1 is the structural front view of filling apparatus in the present invention；
Fig. 2 is the structure enlargement diagram of region A in Fig. 1；
Fig. 3 is that the schematic diagram that 8 center line of bar is splitted is injected on injection tube 2 and injecting mechanism edge；
Fig. 4 is the side view of oral liquid bottle positioning mechanism；
Fig. 5 is the structural schematic diagram of section B-B in Fig. 4；
Fig. 6 is the top view of oral liquid bottle positioning mechanism.
Appended drawing reference: 1- liquid reserve tank, 2- bolus tube, 3- conveyer belt, 4- suction tube, 5- medicine-pouring pipe, 6- check valve, 7- piston
Head, 8- inject bar, 9- oscillating rod, 10- oral liquid bottle, 11- lantern ring, 12- push-pull rod, 13- L shape bar, 14- regulating tank, and 15- turns
Dynamic motor, 16- retarder, 17- bearing one, 18- cylindrical stage, 19- holding tank, 20- rotation axis, 21- gear wheel, the small tooth of 22-
Wheel, 23- driving gear, 24- driving motor, 25- bearing two, 26- bolt one, 27- through-hole one, 28- bolt two, 29- through-hole two,
30- feeding opening, 31- agitating shaft, 32- stirring rod, 33- bearing three, 34- bearing four, 35- bevel gear one, 36- bevel gear two, 41-
Main supporting table, 42- pair supporting table, 43- support plate one, 44- support plate two, 45- supporting plate, 46- limit plate.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawings and examples.
Embodiment 1
A kind of Ni Lapani oral solution, the component including following parts by weight:
10 parts of Ni Lapani；
4 parts of diazepam；
3 parts of malt selenium；
3 parts of vitamin E；
40 parts of filler；
3 parts of rapeseed oil；
4 parts of acetone；
150 parts of deionized water；
Specifically, the filler includes sweetener, aromatic, mucilage, their mass ratio is 2:3:1.
More specifically, the sweetener is protein sugar；
The aromatic is the composition of lemon extract, flavoring apple essence and peppermint oil, their mass ratio is 1:2:1；
The mucilage is sodium alginate.
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 500r/min, diazepam solution obtained in step (I) is first added, adds dimension obtained in step (I)
Raw element E solution, is eventually adding malt selenium and mucilage, stirs evenly, and drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), then 100 DEG C temperature and
Instantaneously sterilising 3s under the pressure environment of 110kpa, last mounted box is to get Ni Lapani oral solution.
Embodiment 2
A kind of Ni Lapani oral solution, the component including following parts by weight:
12 parts of Ni Lapani；
5 parts of diazepam；
4 parts of malt selenium；
4 parts of vitamin E；
35 parts of filler；
4 parts of rapeseed oil；
5 parts of acetone；
145 parts of deionized water；
Specifically, the filler includes sweetener, aromatic, mucilage, their mass ratio is 3:2:1.
Specifically, the sweetener is the composition of protein sugar and stevioside, their mass ratio is 3:1；
The aromatic is the composition of flavoring apple essence and flavoring banana essence, their mass ratio is 1:1；
The mucilage is the composition of methylcellulose, sodium carboxymethylcellulose and sodium alginate, their mass ratio
For 1:1:2.
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 600r/min, diazepam solution obtained in step (I) is first added, adds all components quality
0.5% tween is subsequently added into vitamin E solution obtained in step (I), is eventually adding malt selenium and mucilage, and stirring is equal
It is even, drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), then 100 DEG C temperature and
Instantaneously sterilising 3s under the pressure environment of 110kpa, last mounted box is to get Ni Lapani oral solution.
Embodiment 3
A kind of Ni Lapani oral solution, the component including following parts by weight:
15 parts of Ni Lapani；
6 parts of diazepam；
4.5 parts of malt selenium；
4.5 parts of vitamin E；
30 parts of filler；
5 parts of rapeseed oil；
6 parts of acetone；
140 parts of deionized water；
Specifically, the filler includes sweetener, aromatic, mucilage, their mass ratio is 3:5:2.
Specifically, the sweetener is the composition of protein sugar, xylitol and stevioside, their mass ratio is 2:1:1；
The aromatic is flavoring banana essence；
The mucilage is the composition of sodium carboxymethylcellulose and sodium alginate, their mass ratio is 3:2.
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 650r/min, diazepam solution obtained in step (I) is first added, adds all components quality
0.5% tween is subsequently added into vitamin E solution obtained in step (I), is eventually adding malt selenium and mucilage, and stirring is equal
It is even, drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), then 100 DEG C temperature and
Instantaneously sterilising 3s under the pressure environment of 110kpa, last mounted box is to get Ni Lapani oral solution.
Embodiment 4
A kind of Ni Lapani oral solution, the component including following parts by weight:
18 parts of Ni Lapani；
7 parts of diazepam；
5 parts of malt selenium；
5 parts of vitamin E；
25 parts of filler；
5 parts of rapeseed oil；
7 parts of acetone；
135 parts of deionized water；
Specifically, the filler includes sweetener, aromatic, mucilage, their mass ratio is 3:4:2.
Specifically, the sweetener is the composition of xylitol and stevioside, their mass ratio is 1:1；
The aromatic is the composition of lemon extract, flavoring apple essence, peppermint oil and flavoring banana essence, their mass ratio is
1:2:1:2；
The mucilage is methylcellulose.
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 700r/min, diazepam solution obtained in step (I) is first added, adds all components quality
0.5% tween is subsequently added into vitamin E solution obtained in step (I), is eventually adding malt selenium and mucilage, and stirring is equal
It is even, drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), then 100 DEG C temperature and
Instantaneously sterilising 3s under the pressure environment of 110kpa, last mounted box is to get Ni Lapani oral solution.
Embodiment 5
A kind of Ni Lapani oral solution, the component including following parts by weight:
20 parts of Ni Lapani；
8 parts of diazepam；
6 parts of malt selenium；
6 parts of vitamin E；
20 parts of filler；
6 parts of rapeseed oil；
8 parts of acetone；
130 parts of deionized water；
Specifically, the filler includes sweetener, aromatic, mucilage, their mass ratio is 4:3:2.
Specifically, the sweetener is xylitol；
The aromatic is the composition of lemon extract and peppermint oil, their mass ratio is 2:1；
The mucilage is the composition of methylcellulose and sodium carboxymethylcellulose, their mass ratio is 3:2.
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and
Malt selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, is made
Vitamin E solution is obtained, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), after mixing evenly, in stirring speed
Under conditions of degree is 800r/min, diazepam solution obtained in step (I) is first added, adds all components quality
0.5% tween is subsequently added into vitamin E solution obtained in step (I), is eventually adding malt selenium and mucilage, and stirring is equal
It is even, drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), then 100 DEG C temperature and
Instantaneously sterilising 3s under the pressure environment of 110kpa, last mounted box is to get Ni Lapani oral solution.
A kind of filling apparatus, structure are used when filling in the step of preparation method of the various embodiments described above (III) are as follows:
As shown in Figure 1, the filling apparatus includes that liquid reserve tank 1, bolus tube 2, injecting mechanism, conveyer belt 3, oral liquid bottle stop
Position mechanism and support frame, the bolus tube 2 is set to 1 side of liquid reserve tank vertically, and liquid reserve tank 1 and the close side bottom of bolus tube 2 are logical
The connection of suction tube 4 is crossed, 2 bottom of bolus tube is fixedly connected with the medicine-pouring pipe 5 being vertically arranged, and the suction tube 4 is equipped with direction
The check valve 6 that bolus tube 2 is opened, medicine-pouring pipe 5 are equipped with the check valve 6 opened towards its lower port, and the conveyer belt 3 is used to transport
Defeated oral liquid bottle 10, oral liquid bottle off-position mechanism are set in 3 width direction of conveyer belt and are located at immediately below bolus tube 2, institute
Stating support frame includes being supported in the main supporting table 41 of 1 bottom of liquid reserve tank and the secondary support positioned at bolus tube 2 backwards to 1 side of liquid reserve tank
Platform 42 is fixedly connected with the support plate 1 for being supported in 2 bottom of bolus tube, institute between the main supporting table 41 and secondary supporting table 42
It states support plate 1 and is equipped with the port passed through for medicine-pouring pipe 5；
As shown in Figures 1 and 3, the injecting mechanism includes in bolus tube 2 and periphery is bonded with 2 inner wall of bolus tube
Piston head 7, be fixed in the middle part of 7 top surface of piston head be vertically arranged and pass through 2 top of bolus tube inject bar 8, it is described to inject
8 upper end of bar is hinged with oscillating rod 9, and inject 8 upper end side of bar equipped at least two it is longitudinally-aligned be used to it is hinged with oscillating rod 9
Hinge joint, 9 upper end of oscillating rod are fixed with lantern ring 11, and the 11 internal clearance formula of lantern ring is equipped with horizontally disposed push-pull rod
12, shown 12 both ends of push-pull rod are respectively provided with a L shape bar 13, and 13 vertical portion of L shape bar is equipped with for 12 phase of push-pull rod
The regulating tank 14 for answering end to move up and down；The injecting mechanism further includes the horizontally disposed rotary electric machine 15 of output shaft, and described turn
The output axis connection retarder 16 of dynamic motor 15, the horizontal component of 16 output end of retarder and a L shape bar 13 are coaxial
Formula is connected, and the end of the horizontal component of another L shape bar 13 connects bearing 1, and two L shape bars 13 are about push-pull rod 12
Middle part is symmetrical arranged；15 bottom of rotary electric machine is equipped with the support plate 2 44 being connected in main supporting table 41, the bearing one
17 are fixedly attached in secondary supporting table 42；
As shown in Fig. 4 and Fig. 6, oral liquid bottle off-position mechanism includes two and identical is respectively arranged on 3 width of conveyer belt
The cylindrical stage 18 of direction two sides, 18 side of cylindrical stage equidistantly offer N number of clamping through its own both ends of the surface
Slot 19, N is the even number (here, N takes two) greater than zero, when two corresponding holding tanks 19 of two cylindrical stages 18 turn to position
When between two cylindrical stages 18 and opposite, oral liquid bottle 10 can just be held between the two holding tanks 19；It is described
The rotation axis 20 being vertically arranged is equipped at 18 center of cylindrical stage, fixing sleeve is equipped with intermeshing in two rotation axis 20
Identical gear wheel 21, the gear wheel 21 is located at the lower section of conveyer belt 3, gone back in a rotation axis 20 fixing sleeve be equipped be located at it is big
The pinion gear 22 of 21 lower section of gear, 22 side of pinion gear is equipped with the driving gear 23 of connection driving motor 24, such as Fig. 6 institute
Show, is equidistantly equipped with the gear teeth engaged with pinion gear 22 that one section of corresponding central angle is 180 ° on the driving gear 23, and should
Linear distance between gear teeth end and driving 23 central point of gear is equal to the half of 22 outer diameter of pinion gear；The driving motor 24
Bottom is equipped with the supporting plate 45 being connected in main supporting table 41 and secondary supporting table 42, and 20 lower end of rotation axis is fastened on supporting plate
Bearing 2 25 on 45；It is described driving gear 23 rotate 180 ° time be equal to retarder 16 output shaft rotation half-turn when
Between.
Movement demand is injected in order to better meet, is connected to secondary support as shown in Figure 1, being equipped with above the bolus tube 2
Limit plate 46 on platform 42, the limit plate 46 are equipped with just for injecting the limit hole that bar 8 passes through.Limit hole cuff is being injected
8 side of bar defines that injecting bar 8 can only move up and down.
For the ease of adjust inject bar 8 inject distance, as shown in Fig. 2, at the hinge joint for injecting 8 upper end of bar and pendulum
9 lower end of lever is equipped with the through-hole 1 passed through for bolt 1；It is equipped in the regulating tank 14 and injects the hinged of 8 upper end of bar
The corresponding point of adjustment of point, the point of adjustment and 12 both ends of push-pull rod offer the through-hole 29 passed through for bolt 2 28.Pass through tune
Whole hinge joint and oscillating rod 9 are hinged and by the corresponding through-hole 1 of the insertion of bolt 1, with nut check, while adjusting point of adjustment
It is connect with 12 end of push-pull rod, and bolt 2 28 is inserted into corresponding through-hole 2 29 to be achieved the goal with nut check, it is real
It applies easy to operate.
In order to promote quality of liquid medicine, as shown in Figure 1, the top side of the liquid reserve tank 1 is equipped with feeding opening 30, the liquid storage
Central axis is equipped with the agitating shaft 31 at the top of it in case 1, is uniformly fixed with multiple stirring rods 32, institute on the agitating shaft 31
The bearing 3 33 that 31 upper end of agitating shaft is fastened in support plate 2 44 is stated, 31 lower end of agitating shaft is fastened on liquid reserve tank 1
The bearing 4 34 of interior bottom, 31 upper end side of agitating shaft are located at the part fixing sleeve of 1 top of liquid reserve tank equipped with horizontally disposed
Bevel gear 1, the output end fixing sleeve of the retarder 16 are equipped with and the bevel gear engaged with bevel gear 1 that is vertically arranged
2 36.The output end rotation band dynamic bevel gear 2 36 of retarder 16 rotates, then band dynamic bevel gear 1 rotates, to can drive
Agitating shaft 31 rotates, at this point, stirring rod 32 rotates the stirring action, it can be achieved that medical fluid in liquid reserve tank 1, may advantageously facilitate medicine
Liquid is uniformly dispersed.
The application process of above-mentioned filling apparatus are as follows:
Drug miscible fluid is imported in liquid reserve tank 1 from feeding opening 30, conveyer belt 3 is opened, in order one by one by oral liquid bottle
10 are placed on conveyer belt 3, restart driving motor 24, and driving gear 23 is driven to rotate, only when the gear teeth on driving gear 23
When engaging with pinion gear 22, pinion gear 22 could be driven to rotate, and then drive the rotation of rotation axis 20 where pinion gear 22, this turn
Gear wheel 21 on moving axis 20 rotates with it, and is driven by another gear wheel 21, and another rotation axis 20 is driven to rotate, even if
The reversed rotation of the synchronous progress of two cylindrical stages 18 is obtained, when two corresponding holding tanks 19 of two cylindrical stages 18 turn to
When the side of corresponding 3 feed end of conveyer belt, if just there is oral liquid bottle 10 to be located at this at this time, described two holding tanks 19 are opened
Begin to clamp the oral liquid bottle 10, until holding tank 19 is located between two cylindrical stages 18 and when opposite, oral liquid bottle 10 just by
It is held between the two holding tanks 19, at this point, pinion gear 22 has rotated 180 °, the gear teeth on gear 23 is driven to be detached from and small tooth
The engagement of wheel 22, pinion gear 22 stall, and rotation axis 20, gear wheel 21 and cylindrical stage 18 stall therewith；
When pinion gear 22 starts turning, start rotary electric machine 15, rotation passes to " L " after the deceleration of retarder 16
Shape bar 13 and push-pull rod 12, drive push-pull rod 12 around 13 horizontal component center line of L shape bar rotation (under original state, push-pull rod
12 are located at the bottom of its rotary motion trace, and piston head 7 is located at bottom in bolus tube 2), until push-pull rod 12 is rigid when pinion gear 22 stalls
The lofty perch of its rotary motion trace is turned to well, and in the process, push-pull rod 12 rises, and drives oscillating rod 9 to move up, thus band
It is dynamic to inject bar 8 and move up, pull piston head 7 to move up, the medical fluid in liquid reserve tank 1 is drawn into bolus tube 2 through suction tube 4
Interior, medicine-pouring pipe 5 is equipped with check valve 6 without being pumped into air；
After pinion gear 22 stalls, during driving gear 23 to continue to rotate 180 °, pinion gear 22 cannot be all activated
It rotates, holds an oral liquid bottle 10 between two cylindrical stages 18, although transmission belt keeps continuous transmission, due to cylinder
The blocking of 19 side wall of respective clamp slot on shape block is located at immediately below medicine-pouring pipe 5 so that oral liquid bottle 10 is stablized, can prevent oral solution
Bottle 10 is toppled over；With the lasting rotation of rotary electric machine 15, push-pull rod 12 is driven to start to rotate down, pushes oscillating rod 9 to moving down
Dynamic, drive is injected bar 8 and is moved down, so that medical fluid is filled into oral liquid bottle 10 from medicine-pouring pipe 5, suction tube 4 is equipped with single
It is flow backwards to valve 6 without medical fluid occurs, until push-pull rod 12 and piston head 7 are moved to original state, the medical fluid of suction is fully injected into
In oral liquid bottle 10；In addition, being passed in the rotation process of rotary electric machine 15 by the cooperation of bevel gear 1 and bevel gear 2 36
Dynamic effect, can drive agitating shaft 31 to rotate, and stirring rod 32 is rotated around agitating shaft 31, is stirred to the medical fluid in liquid reserve tank 1, can
Medical fluid is promoted to be uniformly mixed.
Next, the gear teeth on driving gear 23 are engaged with pinion gear 22 again, cylindrical stage 18 is driven to continue to synchronize
And reversed rotation, corresponding two holding tanks 19 are opened to two sides, are disappeared to the clamping action of oral liquid bottle 10, filling medical fluid
Oral liquid bottle 10 with conveyer belt 3, a procedure is mobile downwardly together；Meanwhile next group of holding tank 19 starts to clamp next mouth
Liquid bottle 10 is taken, push-pull rod 12 is begun to move up again, so that piston head 7 moves up, starts aspiration medicinal liquid, can be realized continuous
Filling movement.
To change the filling amount of oral liquid bottle 10, then the different hinge joint in 8 upper end of bar and 9 lower end of oscillating rod are injected in selection
Hingedly, at this point, the height of 9 upper end of oscillating rod changes, need to change position of the push-pull rod 12 in adjustment tank, fixed push-and-pull
After bar 12, it can start to carry out filling.After the driving rotation of rotary electric machine 15, the rotary motion trace of push-pull rod 12 is formed by cylindricality song
The radius in face is different, i.e., the distance that push-pull rod 12 moves up and down changes, so that the distance difference that bar 8 moves up and down is injected,
Because the floor space of bolus tube 2 is constant, the dose once extracted can be obtained by the moving distance of metering piston head 7 at this time,
The dose being once perfused, conversely, just can dose as needed determine the moving distance of piston head 7, so that it is determined that needing to set
The position of fixed hinge joint.Perfusion operation for different perfusion amounts, although the moving distance of piston head 7, push-pull rod 12 is different,
But it is constant, i.e., the time of aspiration medicinal liquid in bolus tube 2 that rotary electric machine 15, which drives the time of the rotation a cycle of push-pull rod 12,
Time with perfusion solution is all constant, to vary without residence time of the oral liquid bottle 10 in filling process.
As shown in the above, filling apparatus operational effect of the present invention is preferable, and operation is more convenient, using valence
It is worth higher.
Those of ordinary skill in the art it should be appreciated that more than embodiment be intended merely to illustrate the present invention,
And be not used as limitation of the invention, as long as the change in spirit of the invention, to embodiment described above
Change, modification will all be fallen in scope of the presently claimed invention.
Claims (9)
1. a kind of Ni Lapani oral solution, which is characterized in that the component including following parts by weight:
10-20 parts of Ni Lapani；
4-8 parts of diazepam；
3-6 parts of malt selenium；
3-6 parts of vitamin E；
20-40 parts of filler；
3-6 parts of rapeseed oil；
4-8 parts of acetone；
130-150 parts of deionized water；
The filler includes sweetener, aromatic, mucilage；
The preparation method of above-mentioned Ni Lapani oral solution includes the following steps:
(I) takes Ni Lapani, diazepam, vitamin E and the malt selenium of powdery respectively, by Ni Lapani, diazepam and malt
Selenium powder is broken and crosses 80 meshes, and diazepam is dissolved in acetone, diazepam solution is made, vitamin E is dissolved in rapeseed oil, dimension is made
Raw element E solution, Ni Lapani and malt selenium are spare；
Ni Lapani, sweetener, aromatic and deionized water are placed in container by (II), and after mixing evenly, low whipping speed is
Under conditions of 500~800r/min, diazepam solution obtained in step (I) is first added, adds dimension obtained in step (I)
Raw element E solution, is eventually adding malt selenium and mucilage, stirs evenly, and drug miscible fluid is made；
(III) is filling in oral liquid bottle by drug miscible fluid obtained in step (II), and mounted box is after instantaneously sterilising to get Buddhist nun
La Pani oral solution.
A kind of filling apparatus, structure are used when filling in the step of above-mentioned preparation method (III) are as follows:
The filling apparatus include liquid reserve tank (1), bolus tube (2), injecting mechanism, conveyer belt (3), oral liquid bottle off-position mechanism and
Support frame, the bolus tube (2) is set to liquid reserve tank (1) side vertically, and liquid reserve tank (1) and the close side bottom of bolus tube (2) are logical
Suction tube (4) connection is crossed, bolus tube (2) bottom is fixedly connected with the medicine-pouring pipe (5) being vertically arranged, on the suction tube (4)
Equipped with the check valve (6) opened towards bolus tube (2), medicine-pouring pipe (5) is equipped with the check valve (6) opened towards its lower port,
The conveyer belt (3) is used to transport oral liquid bottle (10), and oral liquid bottle off-position mechanism is set in conveyer belt (3) width direction
And be located at immediately below bolus tube (2), support frame as described above includes being supported in the main supporting table (41) of liquid reserve tank (1) bottom and positioned at pushing away
It is fixed between the secondary supporting table (42) of liquid reserve tank (1) side, the main supporting table (41) and secondary supporting table (42) to infuse cylinder (2)
It is connected with the support plate one (43) for being supported in bolus tube (2) bottom, the support plate one (43) is equipped with and passes through for medicine-pouring pipe (5)
Port；
The injecting mechanism includes the piston head (7) that in bolus tube (2) and periphery is bonded with bolus tube (2) inner wall, described
It is fixed in the middle part of piston head (7) top surface and is vertically arranged and passes through injecting bar (8) at the top of bolus tube (2), it is described to inject on bar (8)
End is hinged with oscillating rod (9), and inject bar (8) upper end side equipped at least two it is longitudinally-aligned be used to it is hinged with oscillating rod (9)
Hinge joint, oscillating rod (9) upper end is fixed with lantern ring (11), and lantern ring (11) the internal clearance formula is equipped with horizontally disposed
Push-pull rod (12), shown push-pull rod (12) both ends are respectively provided with a L shape bar (13), and L shape bar (13) vertical portion is set up separately
There is the regulating tank (14) moved up and down for push-pull rod (12) respective end；The injecting mechanism further includes that output shaft is horizontally disposed
Rotary electric machine (15), the output axis connection retarder (16) of the rotary electric machine (15), retarder (16) output end and one
The horizontal component coaxial-type of root L shape bar (13) is fixedly connected, the end connecting shaft of the horizontal component of another L shape bar (13)
One (17) are held, two L shape bars (13) are symmetrical arranged about in the middle part of push-pull rod (12)；Rotary electric machine (15) bottom, which is equipped with, to be connected
The support plate two (44) being connected on main supporting table (41), the bearing one (17) are fixedly attached on secondary supporting table (42)；
Oral liquid bottle off-position mechanism includes two identical cylindrical stages for being respectively arranged on conveyer belt (3) width direction two sides
(18), cylindrical stage (18) side equidistantly offers N number of holding tank (19) through its own both ends of the surface, and N is greater than 0
Even number, when two corresponding holding tanks (19) of two cylindrical stages (18) turn between two cylindrical stages (18)
And when opposite, oral liquid bottle (10) can just be held between the two holding tanks (19)；Cylindrical stage (18) center
Place is equipped with the rotation axis (20) being vertically arranged, and fixing sleeve is equipped with intermeshing identical big on two rotation axis (20)
Gear (21), the gear wheel (21) are located at below conveyer belt (3), and fixing sleeve is gone back on a rotation axis (20) and is equipped with positioned at canine tooth
The pinion gear (22) below (21) is taken turns, pinion gear (22) side is equipped with the driving gear (23) of connection driving motor (24),
The gear teeth engaged with pinion gear (22) that N/2 sections of corresponding central angles are 360 °/N are equidistantly equipped on driving gear (23),
And the linear distance between the gear teeth end and driving gear (23) central point is equal to the half of pinion gear (22) outer diameter；The drive
Dynamic motor (24) bottom is equipped with the supporting plate (45) being connected in main supporting table (41) and secondary supporting table (42), the rotation axis (20)
Lower end is fastened on the bearing two (25) on supporting plate (45)；The time that driving gear (23) rotates 360 °/N, which is equal to, slows down
The time of the output shaft rotation half-turn of device (16).
2. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that the sweetener is protein sugar, wood
The composition of any one or more in sugar alcohol and stevioside.
3. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that the aromatic be lemon extract,
The composition of any one or more in flavoring apple essence, peppermint oil and flavoring banana essence.
4. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that the mucilage is Methyl cellulose
The composition of any one or more in element, sodium carboxymethylcellulose and sodium alginate.
5. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that the step of preparation method in (II)
0.5% tween that all components quality is first added is being added between vitamin E.
6. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that the step of preparation method in (III)
The technological parameter of the instantaneously sterilising are as follows: temperature is 100 DEG C, pressure 110kpa, sterilizing time 3s.
7. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that is used in preparation method is filling
The limit plate (46) being connected on secondary supporting table (42) is equipped with above the bolus tube (2) of device, the limit plate (46) is equipped with
Just for injecting the limit hole that bar (8) passes through.
8. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that is used in preparation method is filling
At the hinge joint for injecting bar (8) upper end of device and oscillating rod (9) lower end is equipped with the through-hole one passed through for bolt one (26)
(27)；Point of adjustment corresponding with the hinge joint for injecting bar (8) upper end, the point of adjustment and push-and-pull are equipped in the regulating tank (14)
Bar (12) both ends offer the through-hole two (29) passed through for bolt two (28).
9. a kind of Ni Lapani oral solution according to claim 1, which is characterized in that is used in preparation method is filling
The top side of the liquid reserve tank (1) of device is equipped with feeding opening (30), and the interior central axis of the liquid reserve tank (1) is equipped with through its top
Agitating shaft (31), more stirring rods (32), agitating shaft (31) the upper end connection are uniformly fixed on the agitating shaft (31)
The bearing three (33) being fixed in support plate two (44), agitating shaft (31) lower end are fastened on the axis of liquid reserve tank (1) interior bottom
Four (34) are held, agitating shaft (31) upper end side is located at the part fixing sleeve above liquid reserve tank (1) equipped with horizontally disposed cone tooth
Take turns one (35), the output end fixing sleeve of the retarder (16) is equipped with and the cone tooth engaged with bevel gear one (35) that is vertically arranged
Take turns two (36).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910189326.6A CN110075061A (en) | 2019-03-13 | 2019-03-13 | A kind of Ni Lapani oral solution and preparation method thereof |
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| CN201910189326.6A CN110075061A (en) | 2019-03-13 | 2019-03-13 | A kind of Ni Lapani oral solution and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111907751A (en) * | 2020-07-27 | 2020-11-10 | 四川省洛源食品有限公司 | Quantitative filling equipment for beef tallow |
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| CN108201537A (en) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof |
| CN207759094U (en) * | 2017-12-28 | 2018-08-24 | 江西和盈药业有限公司 | A kind of oral liquid filling machine |
| CN108601789A (en) * | 2015-11-20 | 2018-09-28 | 生华生物科技股份有限公司 | Fourth Ring quinolone analogs combination treatment for treating cancer |
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| US20080160007A1 (en) * | 2007-01-03 | 2008-07-03 | Michael Powell | Diagnosis and treatment of cancer related to human dormancy |
| CN201288055Y (en) * | 2008-11-03 | 2009-08-12 | 祁阳中兴制药机械有限公司 | Vacuum negative pressure oral liquid filling device |
| CN108601789A (en) * | 2015-11-20 | 2018-09-28 | 生华生物科技股份有限公司 | Fourth Ring quinolone analogs combination treatment for treating cancer |
| CN108201537A (en) * | 2016-12-16 | 2018-06-26 | 苏州苏融生物医药有限公司 | A kind of Ni Lapani sustained and controlled release medicaments composition and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111907751A (en) * | 2020-07-27 | 2020-11-10 | 四川省洛源食品有限公司 | Quantitative filling equipment for beef tallow |
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Application publication date: 20190802 |
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