CN110074849A - A kind of fertilization of natural imitation, in conjunction with artificial intelligence Insemination procedures and imitate the device of female reproduction environment - Google Patents
A kind of fertilization of natural imitation, in conjunction with artificial intelligence Insemination procedures and imitate the device of female reproduction environment Download PDFInfo
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- CN110074849A CN110074849A CN201910386506.3A CN201910386506A CN110074849A CN 110074849 A CN110074849 A CN 110074849A CN 201910386506 A CN201910386506 A CN 201910386506A CN 110074849 A CN110074849 A CN 110074849A
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- 238000013473 artificial intelligence Methods 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 27
- 230000009027 insemination Effects 0.000 title claims abstract description 18
- 230000004720 fertilization Effects 0.000 title claims abstract description 17
- 210000004681 ovum Anatomy 0.000 claims abstract description 60
- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 59
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 59
- 210000004996 female reproductive system Anatomy 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 5
- 238000012360 testing method Methods 0.000 claims abstract description 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 6
- 229930091371 Fructose Natural products 0.000 claims description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 5
- 239000005715 Fructose Substances 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000010586 diagram Methods 0.000 claims description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 4
- 102000016943 Muramidase Human genes 0.000 claims description 2
- 108010014251 Muramidase Proteins 0.000 claims description 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims description 2
- 235000014655 lactic acid Nutrition 0.000 claims description 2
- 239000004310 lactic acid Substances 0.000 claims description 2
- 239000004325 lysozyme Substances 0.000 claims description 2
- 235000010335 lysozyme Nutrition 0.000 claims description 2
- 229960000274 lysozyme Drugs 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 235000015097 nutrients Nutrition 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 239000012780 transparent material Substances 0.000 claims description 2
- 230000003321 amplification Effects 0.000 claims 2
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- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000001151 other effect Effects 0.000 claims 2
- 230000019100 sperm motility Effects 0.000 claims 2
- FXLJDRXREUZRIC-BAOOBMCLSA-N (3s,4r,5r)-1,3,4,5,6-pentahydroxyhexan-2-one;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO FXLJDRXREUZRIC-BAOOBMCLSA-N 0.000 claims 1
- 240000007594 Oryza sativa Species 0.000 claims 1
- 235000007164 Oryza sativa Nutrition 0.000 claims 1
- 238000004364 calculation method Methods 0.000 claims 1
- 210000003756 cervix mucus Anatomy 0.000 claims 1
- 238000012937 correction Methods 0.000 claims 1
- 238000005314 correlation function Methods 0.000 claims 1
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- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 235000009566 rice Nutrition 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/42—Gynaecological or obstetrical instruments or methods
- A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
- A61B17/43—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for artificial insemination
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F18/00—Pattern recognition
- G06F18/40—Software arrangements specially adapted for pattern recognition, e.g. user interfaces or toolboxes therefor
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V20/00—Scenes; Scene-specific elements
- G06V20/60—Type of objects
- G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
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- G—PHYSICS
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- G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06V2201/00—Indexing scheme relating to image or video recognition or understanding
- G06V2201/03—Recognition of patterns in medical or anatomical images
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Abstract
A kind of Insemination procedures being planted for mankind or the like, natural imitation fertilization, in conjunction with artificial intelligence, and imitate the device of female reproduction environment, it can be avoided tradition and puncture limitation of the Insemination procedures of oocyte wall on artificial selection sperm, and the deficiency that test-tube baby's method is fairly simple to sperm screening process, and " polyspermy " (polyspermy) phenomenon occurred in tube-test baby techniques can be avoided substantially, insemination success rate is improved, Issues of Human Assisted Reproductive Technologies field and field of computer technology are belonged to；Innovation of the invention includes: to imitate female reproductive system using apparatus of the present invention, to achieve the purpose that natural imitation fertilization process, it is detected using artificial intelligence based on computer vision and judges that ovum has been fertilized, come selective fertilization scheme and setting fertilization environment using computer experience, utmostly to screen sperm, guarantee more scientific inhereditary material.It is contemplated that the present invention may be use with substituting other artificial insemination protocols when replace-conceive.
Description
Technical field
This disclosure relates to Issues of Human Assisted Reproductive Technologies field and field of computer technology, in particular to a kind of imitation
Natural fertilization, Insemination procedures in conjunction with artificial intelligence, and imitate the device of female reproduction environment.
Background technique
Test-tube baby is to treat infertile one of main method at present, female patient with ovulation failure or is suffered from
The male patient of oligoasthenospermia can be given birth to by tube-test baby techniques, so that it is infertile to solve disease bring
Puzzlement, but tube-test baby techniques are limited to the screening of sperm, and this method imitates female reproductive system, thus close to natural fertilization side
Method screens sperm, and by artificial intelligence system based on computer vision, can avoid traditional test-tube baby substantially
" polyspermy " (polyspermy) phenomenon occurred in method, and using computer experience come selective fertilization scheme and guidance by
Smart environment setting, more to screen sperm；The present invention can also select the women of replace-conceive to mention to consider for factors such as ages
Required inhereditary material when for replace-conceive.
Summary of the invention
The disclosure is designed to provide a kind of fertilization of natural imitation, Insemination procedures in conjunction with artificial intelligence, Yi Jimo
The device of imitative female reproduction environment.
According to one aspect of the disclosure, a kind of device imitating female reproduction environment is provided, comprising: ovum layout points,
Sperm layout points imitate the path bifurcated without ovum ovary, the connecting path of ovum layout points and each sperm layout points, Yi Jiyong
In the culture solution for imitating female reproduction environment, wherein different sperm layout points have a difference at a distance from ovum layout points, sperm from
Sperm layout points are set out, and are had sperm and are swum direction to ovum layout points, complete to be fertilized to ovum to meet.
Preferably, " device for imitating female reproduction environment " uses transparent material, can be glass material, to facilitate aobvious
It is observed in micro mirror.
Optionally, in the connecting path of sperm and ovum, there is the access without ovum to imitate two ovaries of women
That ovary of middle no ovum, referring to Fig.1.
It is alternatively possible to which the region for imitating that ovary without ovum in two ovaries of women is increased pure water and sperm cloth
Culture solution in area is set to be connected.
Preferably, the main component of culture solution be water, Bacillus acidi lactici, fructose, propylene glycol (or the like), make it as far as possible
Ph value can add on a small quantity lysozyme, lactic acid according to sperm quality or demand 4.3 or so.
Further, the situation by weight ratio of the main component of culture solution: Bacillus acidi lactici (about 1% or so), fructose are (about
2% or so), propylene glycol (about 0.8% or so), remaining is mainly water, can modify proportion according to actual needs.
Further, the mixing of fructose and Bacillus acidi lactici, which can be, mixes during dropping liquid to reach proportion above,
It can also be mixed in advance according to proportion above, and the specific proportion of culture solution can also be modified as needed, for various screening mesh
Service.
It is alternatively possible to one layer of layer overlay Bacillus acidi lactici powder or placement on the device for imitating female reproduction environment
Bacillus acidi lactici powder pad, with reference to Fig. 1 schematic diagram, if for some reason (such as convenient for observing the sperm figure in wherein certain stage
Shape) without increasing this layer of powder, then it can suitably increase accounting of the Bacillus acidi lactici in culture solution.
It optionally, can be in the edge of sperm layout area in order to which relatively specific mark is at a distance from ovum layout points
Increase scale to indicate at a distance from ovum arrangement area.
According to one aspect of the disclosure, provide it is a kind of based on computer vision, to " imitating the dress of female reproduction environment
Set " in addition culture solution device, comprising: one for observing the camera of the device of female reproduction environment " imitate ", by " mould
Fix, specified altitude assignment is lifted in one end and adheres to the electronic controller of specified time by one end for the device of imitative female reproduction environment ", according to
Computer vision identifies the addition degree of culture solution, and continuously the angle of adjustment " imitating the device of female reproduction environment " to control
Culture solution processed flows down, with reference to Fig. 2 schematic diagram.
Preferably, the features such as change colour when identifying that liquid is mixed with powder slightly by computer vision to judge currently to train
The degree of nutrient solution addition, as main foundation to reach supervision and control to addition culture solution process.
According to one aspect of the disclosure, provide it is a kind of based on computer vision, monitoring ovum fertilization situation it is artificial
Intelligence system, just to provide prompt after ovum is fertilized for the first time, to avoid " polyspermy " (polyspermy) existing
As.
Preferably, the computer vision system of artificial intelligence can store different resolution, different microscope times magnifications first
The regular information of several lower ovums and sperm size and appearance, according to currently used resolution ratio and microscope times magnification when operation
The parameters such as number carry out pattern-recognition from the experience library summarized in advance, identify the sperm and ovum in picture.
The difficulty identified when preferably, in order to reduce operation, and increase identification accuracy, it completes to be arranged in microscope
Afterwards, in artificial intelligence system display interface, the method for ovum is selected by operator's circle to allow artificial intelligence system preferably to look for
It arrives and identifies ovum, the ovum recognized is graphically marked in artificial intelligence system interface, and can be according to artificial intelligence
Frame selects or marks the ovum in artificial intelligence interface the recognition result that system interface is shown repeatedly, in the hope of to the best of ovum
Recognition effect.
Preferably, the temporal regularity that artificial intelligence system passes through that the sperm collected in advance is attached on ovum count to obtain through
Library is tested, and can identify characteristics of image when inseminating successfully in conjunction with MIcrosope image to determine that fertilization is completed, and in judgement insemination
Prompt is provided when completion.
Preferably, main standard when being inseminated successfully by MIcrosope image identification is the variation of ovum appearance, is led to
Appearance variation before a period of time stored before crossing is compared, and thinks that insemination is completed when meeting a threshold value.
Preferably as a kind of optional embodiment, the successful feature of ovum fertilization includes but is not limited to artificial intelligence
System, compared to being changed before more several frames, specifically becomes smaller from the size for comparing ovum in picture frame；
According to one aspect of the disclosure, one kind is provided under given resolution and microscope multiple, according in MIcrosope image
The quantity of sperm and vigor determine the people using which sperm layout points or sperm layout points at a distance from ovum arrangement area
Work intellectual analysis decision system.
Preferably, the essence of continuous multiple frames image under the microscope that artificial intelligence analysis's decision system is shot according to picture pick-up device
Sub- change information it is known that sperm vigor and density, more specific says, be by this information noise reduction quantization after, obtain every frame
Marginal information be compared, by the computer experience library that is stored in the read-write medium of corresponding computer come according to marginal information
Variation frequent degree determine the sperm layout points used, computer experience mentioned herein library is in advance according to different sperms
Under vigor and density, what the length of fertilization time was counted with fertilization success rate, and can lead in actual use
Cross the information in the suitably modified experience library of new data.
Further, judge that the method for sperm concentration and vigor is more according to microscope continuous multiple frames image information, including
But it is not limited to determine the edge of all biological informations in image after image gray processing, all edges letters in successive frame are compared in worry after making an uproar
The methods of situation of change of breath, and precision and target hardware can select or combine each method according to demand.
Detailed description of the invention
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing.
Fig. 1: conceptually illustrating the general layout schematic diagram for imitating female reproduction environmental device, and Fig. 1, which is only laid out, to be shown
It is intended to, is not used as the constraint present invention.
Fig. 2: being the schematic device of machine addition culture solution in " device for imitating female reproduction environment ", and Fig. 2 is
Schematic layout pattern is not used as the constraint present invention.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Sperm is taken out, microscopically observation is placed on, by image transmitting into artificial intelligence analysis's decision system, passes through people
Work intellectual analysis decision system analyzes the vigor of sperm, mentions at a distance from ovum layout points to provide the sperm layout points used
Show, the unit for providing prompt can be millimeter.
The device for imitating female reproduction environment is placed on the device of addition culture solution and carries out culture solution addition, such as Fig. 2.
Culture solution is added to after designated position, and the device for imitating female reproduction environment is taken out and is placed under the microscope,
Ovum is arranged in ovum arrangement area, later the ovum from the program interface for connecting microscopical computer, adjustment focal length is extremely
After picture is clear, ovum is selected in artificial intelligence system display interface center of the present invention, is identified until to artificial intelligence system
Until ovum situation out is relatively satisfactory.
Arrange that sperm in specified sperm layout points, waits the prompt of computer controlled stage later.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (7)
- Insemination procedures that 1. a kind of natural imitation is fertilized, in conjunction with artificial intelligence, and the device of female reproduction environment is imitated, It is characterized in that, comprising:Step 1: artificial intelligence system estimates the density and vigor of current sperm according to consecutive image frame information under microscope, Suitable sperm position is analyzed by experience library, and the position of arrangement sperm can be prompted with mm length value；Step 2: arrangement is imitated on the device to culture solution adding set of female reproductive system, and adds culture solution connection ovum Arrange area at specified sperm position；Step 3: ovum arrangement area arrange ovum, then by microscope camera by image transmitting into artificial intelligence system Monitoring, and select function and interface to feed back to check and adjust knowledge of the artificial intelligence system to ovum using the frame of artificial intelligence system Other effect；Step 4: sperm is arranged in sperm layout points, is then identified by artificial intelligence system based on computer vision Ovum insemination out is completed, and prompts to complete to inseminate.
- " step 1 " 2. according to claim 1, which is characterized in that artificial intelligence system is according to consecutive image under microscope Frame information estimates the density and vigor of current sperm, and suitable sperm position is analyzed by experience library, can with milli The position of rice length value prompt arrangement sperm, comprising:To that sperm will be used to sample, artificial intelligence can be analyzed according to the sequential frame image information of sampling under the microscope The density and vigor of sperm out, and sperm concentration and vigor are converted into quantized values, it is total by the quantized values collected before The experience library born determines to provide prompt in millimeters using closer or farther away sperm position；The data such as vigor and the density of the prior target sperm sample inferred or collected be may be used herein to calculate arrangement sperm Position, to avoid to sperm specimen sample.
- " step 2 " 3. according to claim 1, which is characterized in that the device of arrangement imitation female reproductive system to culture On liquid adding set, and add at culture solution connection ovum arrangement area and specified sperm position, comprising:" device for imitating female reproductive system " can be a kind of transparent material, and reference view 1 can be with tape label so as to aobvious The position to be observed faster is found under micro mirror, can also different sperm layout points add it is macroscopic label or Scale；It, can be by the designated position of " device for imitating female reproductive system " in the environment of moisturizing and temperature higher than 30 degrees Celsius Layer overlay Bacillus acidi lactici powder (or placing one layer of Bacillus acidi lactici powder pad), and this device is arranged and is fixed on addition culture Culture solution is added in liquid electronic equipment；As an alternative embodiment, the main component of culture solution is water, Bacillus acidi lactici, fructose, propylene glycol can increase Appropriate lysozyme and lactic acid come closer to vaginal secretion ingredient；It is trained using addition culture solution electronic equipment from from ovum arrangement or adjacent to being added into sperm arrangement area according to designated mode Nutrient solution, until allowing culture solution to flow to specified sperm layout area, computer vision can tilt fixation as needed in adding procedure There is the panel of " device for imitating female reproductive system ", to control the trickling speed of culture solution, and flows to target essence in culture solution Prompt is provided when sub- layout area；As an alternative embodiment, the electronic equipment of the addition culture solution may include a dropping liquid equipment, one Axis controls equipment, and a computer vision system, a camera, referring to Fig. 3, axis control equipment can be modified " imitates schematic diagram The angle of the device of female reproductive system ", to control the speed of culture solution flowing；As an alternative embodiment, the electronic equipment of the addition culture solution may include a dropping liquid equipment, one Axis controls equipment, and axis control equipment can modify the angle of " device for imitating female reproductive system " according to the mode that certain is fixed Degree, the relevant parameters such as this fixed mode elevation angle, residence time on the elevation angle, which can be realized, specifies, then according to it is different away from From etc. parameters one waiting time is obtained by computer experience library, set and wait alarm clock prompting to observe again after certain alarm clock The addition situation of culture solution；As an alternative embodiment, the Bacillus acidi lactici and fructose in the culture solution can proportionally be split into two kinds Liquid, the mixing when above-mentioned dropping liquid equipment is dripped can also be admixed together according to specified proportion in advance；As an alternative embodiment, culture solution can also be added by manual type, to save the electricity of addition culture solution Sub- equipment；As an alternative embodiment, " device for imitating female reproductive system " can be the essence of a variety of different lengths The equipment of subpath, to simplify the quantity at sperm arrangement to 1, not shared part is logical at different sperm arrangements after simplified Road；As an alternative embodiment, " device for imitating female reproductive system " can also only have a kind of specification, and It is set at sperm arrangement by measurement or scale in millimeters.
- " step 3 " 4. according to claim 1, which is characterized in that ovum is arranged in ovum arrangement area, then by aobvious Micro mirror camera monitors image transmitting into artificial intelligence system, and selects function and interface to feed back to check and adjust people using frame Recognition effect of the work intelligence system to ovum, comprising:Ovum is arranged in " ovum rest area ", then adds pure water or low concentration fructose water if necessary, arranges ovum Region is connected with culture solution by liquid；Here the microscope and computer connection type arranged are that camera is mounted on individually camera shooting mouth rather than preferential attachment eyepiece, Then camera connects computer by usb line or other modes to transmit image, artificial intelligence system is obtained in real time aobvious The magazine image information of micro mirror, camera can be with independent lens or use dedicated for microscopical camera, according to selected phase Machine and its camera lens scheme carry out micrograph results verification by software interface to recalculate required object lens multiple；After ovum is placed on specified region, adjustment microscope focus and the suitable object lens of selection (mainly use 10 to 40 times of models Object lens are enclosed, a kind of our test configurations should be the camera for about 30 times of amplifications that 20 times of object lens combine us to buy, practical The specific object lens multiple selection of deployment will also be in conjunction with relevant parameter and amplification factor the imaging effect obtained for the camera being equipped with Whether fruit adjusts, determine that foundation of object lens multiple can be can be by by the scale for having a look Microscope gauge 0.01mm It is shown in the picture according to expected situation, or examines ovum imaging effect according to software systems, further adjusted according to result Object lens multiple), the image of camera is passed to Artificial intelligence system after adjusting, and microscope multiple information is defeated Enter into artificial intelligence system, manual frame can select in the graphical observing interface of artificial intelligence later or mark ovum, manually Intelligence system is by increasing the ovum identified several seconds edge flare special efficacys in observing interface, to show the knowledge to ovum Other effect, operator can carry out again frame choosing or label to the ovum shown in observing interface if necessary, best to pursue Recognition effect meets particular demands, and timely correction if necessary.
- " step 4 " 5. according to claim 1, which is characterized in that sperm is arranged in sperm layout points, is then passed through It identifies that ovum insemination is completed by artificial intelligence system based on computer vision, and prompts to complete to inseminate, comprising:Go out the corresponding different sperms of sperm motility quantized value that artificial intelligence provides by experimental summary of repeatedly inseminating in advance to place These times are converted computer experience library by the time of insemination in area；As an alternative embodiment, in order to avoid there is the case where no sperm is screened in time, it can be to meter Calculation machine visual experience library increases one mode, is exactly first to arrange the logical of area using some sperm of micro- sem observation arrangement area and ovum If a position in road can prompt to operate still do not see that sperm occurs in this position at some time point Personnel increase sperm, that is to say, that look first at whether sperm has swum over to some position, observation position is adjusted if having swum over to It sets, then system prompt removes observation ovular area, since entire Process of Insemination is carried out on the same transparent unit, it is possible to Point of observation is adjusted by movement " imitating the device of female reproductive system " to reach this purpose；Artificial intelligence can be according to the sperm motility situation and the successful feature of ovum fertilization etc. that image under microscope is observed Information carrys out comprehensive descision ovum and successfully inseminates, and is determining to provide prompt when inseminating successfully；As an alternative embodiment, the size that the successful feature of ovum fertilization includes but is not limited to ovum is become Change；It is observed in conjunction with experience library and artificial intelligence system, in addition the Process of Insemination of the method is similar to natural conception to the sieve of sperm Choosing, sperm quantity when insemination is completed around ovum is limited, so relatively can be avoided the feelings of " polyspermy " (polyspermy) Condition.
- 6. a set of be stored in the computer-readable computer vision artificial intelligence software's system write in medium, ovum can be identified Son, detection insemination are completed, identify the functions such as sperm quality, discovery sperm.
- 7. a kind of electronic equipment characterized by comprisingOne or more processors；Storage device, for storing one or more programs, when one or more of programs are by one or more of processing When device executes, so that one or more of processors realize correlation function of the invention, and result is obtained by video card Video output.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021121077A1 (en) * | 2019-12-18 | 2021-06-24 | 于毅欣 | Method for screening sperm during artificial insemination |
| WO2021190644A1 (en) * | 2020-03-27 | 2021-09-30 | 于毅欣 | Method for screening sperm during artificial insemination |
| CN114550554A (en) * | 2022-02-24 | 2022-05-27 | 泉州医学高等专科学校 | Virtual simulation teaching system for embryology fusing VR game |
-
2019
- 2019-05-09 CN CN201910386506.3A patent/CN110074849A/en active Pending
Cited By (3)
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| WO2021121077A1 (en) * | 2019-12-18 | 2021-06-24 | 于毅欣 | Method for screening sperm during artificial insemination |
| WO2021190644A1 (en) * | 2020-03-27 | 2021-09-30 | 于毅欣 | Method for screening sperm during artificial insemination |
| CN114550554A (en) * | 2022-02-24 | 2022-05-27 | 泉州医学高等专科学校 | Virtual simulation teaching system for embryology fusing VR game |
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