CN110069168B - Microfluidic device, operating method for microfluidic device and control device - Google Patents
Microfluidic device, operating method for microfluidic device and control device Download PDFInfo
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- CN110069168B CN110069168B CN201910368331.3A CN201910368331A CN110069168B CN 110069168 B CN110069168 B CN 110069168B CN 201910368331 A CN201910368331 A CN 201910368331A CN 110069168 B CN110069168 B CN 110069168B
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- microfluidic chip
- microfluidic
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
- G06F3/03—Arrangements for converting the position or the displacement of a member into a coded form
- G06F3/041—Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
- G06F3/0412—Digitisers structurally integrated in a display
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
- G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
- G06F3/048—Interaction techniques based on graphical user interfaces [GUI]
- G06F3/0487—Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser
- G06F3/0488—Interaction techniques based on graphical user interfaces [GUI] using specific features provided by the input device, e.g. functions controlled by the rotation of a mouse with dual sensing arrangements, or of the nature of the input device, e.g. tap gestures based on pressure sensed by a digitiser using a touch-screen or digitiser, e.g. input of commands through traced gestures
Abstract
A microfluidic device, an operating method for the microfluidic device, and a control device. The microfluidic device comprises: the touch panel is used for detecting a contact action on a touch surface of the touch panel; and the micro-fluidic chip is used for executing preset operation on the target liquid drop according to the detected contact action.
Description
Technical Field
Embodiments of the present disclosure relate to a microfluidic device, an operating method for a microfluidic device, and a control device.
Background
At present, a microfluidic chip has a path for liquid drop movement designed in advance, so that after the design is finished, a microfluidic driving circuit can only drive and process the existing path. For example, several buttons with specific functions are pre-designed for a finished microfluidic chip, and when the microfluidic chip is used, only one of the functions can be selected, so that relatively limited functions can be realized.
Disclosure of Invention
At least one embodiment of the present disclosure provides a microfluidic device, comprising:
the touch panel is used for detecting a contact action on a touch surface of the touch panel; and
and the microfluidic chip is used for executing preset operation on the target liquid drop according to the detected contact action.
For example, the microfluidic device according to at least one embodiment of the present disclosure further includes a display panel, wherein the display panel is configured to display the target droplet,
the touch panel is located on a display side of the display panel, an
The micro-fluidic chip is used for operating the target liquid drop displayed on the display panel according to the contact action and executing the preset operation on the target liquid drop.
For example, the microfluidic device according to at least one embodiment of the present disclosure further includes an image acquisition device, wherein the image acquisition device is configured to acquire image information of the target droplet and transmit the image information of the target droplet to the display panel, and
the display panel is used for displaying the target liquid drop based on the image information of the target liquid drop.
For example, the microfluidic device according to at least one embodiment of the present disclosure further includes a controller, wherein the controller is in signal connection with the touch panel and the microfluidic chip, and is configured to control the microfluidic chip to perform the preset operation on the target droplet in response to the contact action detected by the touch panel.
For example, in a microfluidic device according to at least one embodiment of the present disclosure, the controller is further configured to plan a movement route of the target droplet according to the contact action, and control the microfluidic chip to drive the target droplet to move according to the movement route.
For example, in a microfluidic device according to at least one embodiment of the present disclosure, any two of the touch panel, the microfluidic chip, and the controller are detachably connected.
For example, in a microfluidic device according to at least one embodiment of the present disclosure, a detection region of the touch panel corresponds to an operation region of the microfluidic chip.
For example, in a microfluidic device according to at least one embodiment of the present disclosure, the touch panel and the microfluidic chip overlap, and the detection region of the touch panel is at least partially transparent, so that the operation region of the microfluidic chip is visible.
At least one embodiment of the present disclosure also provides a control apparatus, including: a controller, a first interface and a second interface, wherein the first interface is configured to be in signal connection with the touch panel, the second interface is configured to be in signal connection with the microfluidic chip,
the controller is configured to obtain a detection result of the touch panel on the contact action, and control the micro-fluidic chip to execute preset operation on the target liquid drop according to the detection result.
At least one embodiment of the present disclosure also provides a method of operation for a microfluidic device including a touch panel and a microfluidic chip, the method including:
detecting a contact action on a touch surface of the touch panel through the touch panel; and
and executing preset operation on the target liquid drop through the microfluidic chip according to the detected contact action.
For example, in a method of operation according to at least one embodiment of the present disclosure, the microfluidic device further includes a display panel for displaying the target droplet, and
the method further comprises the following steps: displaying the target droplet through the display panel.
For example, in an operation method according to at least one embodiment of the present disclosure, the step of performing a preset operation on a target droplet by the microfluidic chip according to the detected contact action includes:
and executing the preset operation on the target liquid drop by the micro-fluidic chip according to the operation of the contact touch on the target liquid drop displayed on the display panel.
For example, in a method of operation according to at least one embodiment of the present disclosure, the microfluidic device further comprises an image acquisition device, and
the displaying, by the display panel, the target droplet includes:
acquiring image information of the target liquid drop through the image acquisition device, and transmitting the image information of the target liquid drop to the display panel; and
displaying, by the display panel, the target droplet based on image information of the target droplet.
For example, in a method of operation according to at least one embodiment of the present disclosure, the microfluidic device further includes a controller in signal connection with the touch panel and the microfluidic chip, an
The performing, by the microfluidic chip, the preset operation on the target droplet according to the detected contact action includes: and responding to the contact action detected by the touch panel, and controlling the microfluidic chip by the controller to execute the preset operation on the target liquid drop according to the detected contact action.
For example, in an operation method according to at least one embodiment of the present disclosure, the preset operation includes at least one of: moving, separating, polymerizing, applying voltage, and heating.
For example, in a method of operation in accordance with at least one embodiment of the present disclosure, the contact action includes a click action, and
the target liquid drop is a liquid drop which is positioned at a corresponding position of the occurrence position of the clicking action on the microfluidic chip.
For example, in a method of operation according to at least one embodiment of the present disclosure, the act of contacting comprises: a sliding motion starting from a first position on the touch panel and continuing to a second position on the touch panel, an
The target liquid drop is a liquid drop positioned on a corresponding track of the sliding action on the microfluidic chip.
For example, in an operation method according to at least one embodiment of the present disclosure, the step of performing a preset operation on the target droplet by the microfluidic chip according to the detected contact action includes:
and planning a movement route of the target liquid drop according to the sliding motion track detected by the touch panel, and controlling the microfluidic chip to drive the target liquid drop to move according to the movement route.
Drawings
To more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings of the embodiments will be briefly introduced below, and it is apparent that the drawings in the following description relate only to some embodiments of the present disclosure and are not limiting to the present disclosure.
Fig. 1 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure.
Fig. 2 is a schematic structural diagram of a touch panel according to at least one embodiment of the present disclosure.
Fig. 3 is a top view of a microfluidic chip according to at least one embodiment of the present disclosure.
Fig. 4 is a sectional view taken along line L-L' in fig. 3.
Fig. 5 is a schematic structural diagram of a control device according to at least one embodiment of the present disclosure.
Fig. 6 is a schematic diagram of an example of a trajectory of a contact action on a touch panel according to at least one embodiment of the present disclosure.
Fig. 7 is another schematic structural diagram of a control device according to at least one embodiment of the present disclosure.
Fig. 8 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure.
Fig. 9 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure.
Fig. 10 is a schematic flow diagram of a method of operation for a microfluidic device according to at least one embodiment of the present disclosure.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present disclosure more clear, the technical solutions of the embodiments of the present disclosure will be described below clearly and completely with reference to the accompanying drawings of the embodiments of the present disclosure. It is to be understood that the described embodiments are only a few embodiments of the present disclosure, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the disclosure without any inventive step, are within the scope of protection of the disclosure.
Unless otherwise defined, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The use of "first," "second," and similar terms in this disclosure is not intended to indicate any order, quantity, or importance, but rather is used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item preceding the word comprises the element or item listed after the word and its equivalent, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
To maintain the following description of the embodiments of the present disclosure clear and concise, a detailed description of known functions and known components have been omitted from the present disclosure.
As described above, at present, the microfluidic chip has a path designed in advance for the movement of a droplet, so after the design is completed, the microfluidic driving circuit can only perform driving processing on the existing path.
At least one embodiment of the present disclosure provides a microfluidic device, an operating method for the microfluidic device, and a control device, which can control a microfluidic chip through a touch panel to operate a liquid to be detected, so that the operating method is more flexible and the functions are richer.
Fig. 1 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure. As shown in fig. 1, a microfluidic device 100 according to at least one embodiment of the present disclosure includes a touch panel 110, a microfluidic chip 120, and a control device 130.
The touch panel 110 is used to detect contact actions on the touch surface of the touch panel 110, and the contact actions may include clicking, double clicking, long touching, sliding, and the like. The touch panel 110 may generate a detection signal according to a contact action on a touch surface of the touch panel 110. The detection signal may include a signal indicating position information of the contact action on the touch panel 110, a signal indicating pressing strength information of the contact action on the touch panel 110, a signal indicating duration information of the contact action on the touch panel 110, and the like. The position information may include, for example, coordinate information of the contact action on the touch panel 110.
The touch panel 110 may include, for example and without limitation, a resistive touch panel, an infrared touch panel, a surface acoustic wave touch panel, and a capacitive touch panel, and the embodiment of the present disclosure is not limited thereto.
In some embodiments, the detection area of the touch panel 110 corresponds to the operation area of the microfluidic chip 120, for example, in a case where the touch panel 110 overlaps the microfluidic chip 120, a projection of the detection area of the touch panel 110 on the microfluidic chip 120 is greater than or equal to the operation area of the microfluidic chip 120, so that the operation of the microfluidic chip 120 seen through the touch panel 110 by a user can be detected; for another example, in a case where the microfluidic device 100 further includes a display panel for displaying an image of the microfluidic chip 120 and the display panel overlaps the touch panel 110, a projection of the detection area of the touch panel 110 on the display panel is greater than or equal to an operation area of the microfluidic chip 120 displayed on the display panel, so that the operation of the microfluidic chip 120 seen through the touch panel 110 by the user can be detected. For example, in the microfluidic device 100 shown in fig. 1, the touch panel 110 may overlap the microfluidic chip 120 one above the other, with the touch panel 110 on the side facing the user, so that the user may perform a touch operation, and specifically, the detection region of the touch panel 110 may cover the operation region of the microfluidic chip 120 so as to overlap the operation region of the microfluidic chip 120. The detection area of the touch panel 110 may be at least partially transparent so that the operation area of the microfluidic chip 120 located on the back side of the touch panel 110 is visible, so that a user can visually observe and control the movement of the target droplet. For example, the detection regions of the touch panel 110 may have different degrees of transmittance, such as 100%, 90%, 80%, 70%, 60%, 50%, 40%, 30%, 20%, 10%, or 5% transmittance, which is not limited by the embodiments of the disclosure.
Fig. 2 is a schematic structural diagram of a touch panel according to at least one embodiment of the present disclosure. As shown in fig. 2, the touch panel 110 is a capacitive touch panel that is of a mutual capacitive type and includes a substrate 111, a plurality of first electrode bars 112, a plurality of second electrode bars 113, a second signal line 114, and a first signal line 115. Substrate 111 includes a detection zone 1111 and a lead zone 1112 located around detection zone 1111; a plurality of first electrode strips 112 are arranged in parallel on the substrate 111 of the detection region 1111, and each first electrode strip 112 includes a plurality of first sub-electrodes arranged at intervals; a plurality of second electrode strips 113 are arranged in parallel on the substrate 111 in the detection region 1111, each second electrode strip 113 includes a plurality of second sub-electrodes arranged at intervals, and an extension line where the second electrode strip 113 is located and an extension line where the first electrode strip 112 is located are arranged to intersect with each other; the first signal line 115 is connected to the first electrode 112, and the second signal line 114 is connected to the second electrode 113. The first electrode stripes 112 and the second electrode stripes 113 are located in the detection region, and the second signal lines 114 and the first signal lines 115 are located in the lead region 1112.
In the touch panel, one of the first sub-electrode and the second sub-electrode may be a driving electrode, and the other may be a sensing electrode. An induction capacitor can be formed between the first sub-electrode and the second sub-electrode crossed with the first sub-electrode at the crossed position, so that the plurality of first sub-electrodes and the plurality of second sub-electrodes are crossed with each other, and an array of induction capacitors is obtained in the detection area and is used for detecting touch operation. When a foreign object (such as a finger or the like) approaches a certain sensing capacitor, the capacitance of the sensing capacitor between the first sub-electrode and the second sub-electrode in the corresponding region is changed. The contact point can be positioned by detecting the position of the corresponding sensing capacitor having the changed capacitance through the second signal line 114 and the first signal line 115.
The first signal line 115 and the second signal line 114 may converge to the port region B to facilitate electrical connection with an external control unit, such as a control device, etc., through, for example, a flexible circuit board.
For example, the substrate 111 may be a single transparent substrate, such as a glass substrate, a plastic substrate, or the like, or may be a surface layer of the microfluidic chip 120, such as a protective cover (e.g., a glass substrate, a plastic substrate, or the like) or an encapsulation layer of the microfluidic chip 120, or the like. The first electrode stripes 112 and the second electrode stripes 113 may be made of, for example, a transparent conductive material (e.g., ITO); the first electrode stripes 112 and the second electrode stripes 113 may be located in different layers on the substrate 111, separated by at least one insulating layer, thereby achieving extending in different directions and crossing each other, or the first electrode stripes 112 and the second electrode stripes 113 may be located in the same layer on the substrate 111, but insulated by crossing in a bridging manner at positions crossing each other. The second signal line 114 and the first signal line 115 may be made of, for example, aluminum or an aluminum alloy, copper or a copper alloy, or the like.
It should be understood that the touch panel 110 shown in fig. 2 is merely exemplary, and embodiments of the present disclosure are not limited thereto.
The micro-fluidic chip 120 is used to perform a preset operation on a target droplet according to the detected contact action, wherein the target droplet is on the micro-fluidic chip 120 or in the micro-fluidic chip 120. The preset operation may include, but is not limited to, moving the target droplet, separating the target droplet, polymerizing the target droplet, applying a voltage to the target droplet, heating the target droplet, and the like, and embodiments of the present disclosure are not limited thereto.
Fig. 3 is a top view of a microfluidic chip according to at least one embodiment of the present disclosure, and fig. 4 is a cross-sectional view taken along line L-L' in fig. 3. As shown in fig. 3, the microfluidic chip 120 includes an operation area 1221 shown by a dashed box, the operation area 1221 includes a driving array, the driving array includes a plurality of driving units 1222 distributed in the array, and each driving unit 1222 is configured to operate on a droplet under the control of an electrical signal.
As shown in fig. 4, the driving unit 1222 is located on the substrate base plate 401. The driving unit 1222 may be directly formed on the substrate base 401, or may be prepared as a separate device and then bonded to the substrate base 401 by means of bonding. The substrate 401 may be a glass substrate, a plastic substrate, or the like.
For example, the microfluidic chip 120 may adopt a passive driving manner or an active driving manner, and the embodiment of the disclosure is not limited thereto. The active drive method is explained below as an example.
For the active driving manner, for example, each driving unit 1222 may include a switching element and a driving electrode 409 electrically connected to the switching element. The drive electrodes 409 operate on the droplets with a voltage applied. Each for providing a drive signal to one or more drive electrodes 409. For example, the switching elements correspond one-to-one to the driving electrodes 409. As an example, in fig. 4, the switching element is illustrated in the form of a thin film transistor, however, one skilled in the art can appreciate that the switching element may also be implemented in other forms, such as a field effect transistor, and the embodiment of the present disclosure is not limited thereto. The driving electrode 409 may be formed of, for example, a metal (e.g., an alloy), a doped semiconductor material (e.g., polysilicon), an oxide conductive material (e.g., Indium Tin Oxide (ITO), indium tin oxide (IZO)), or any other suitable material, which is not limited in this respect by the embodiments of the present disclosure.
As shown in fig. 4, a switching element such as a thin film transistor may include a gate electrode 402, a gate insulating layer 403, an active layer 404, a first pole 405, and a second pole 406. As an example, in some embodiments of the disclosure, the first pole 405 is a source electrode and the second pole 406 is a drain electrode, however, in other embodiments, the first pole 405 may also be a drain electrode and the second pole 406 may also be a source electrode, which is not limited by the embodiments of the disclosure. An insulating layer or dielectric layer 407 is formed between the driving electrode 409 and the thin film transistor. The drive electrode 409 is in electrical contact with the second pole 406 through a via 408 in the insulating layer 407 to receive an electrical signal from the second pole 406.
As shown in fig. 4, the microfluidic chip 120 may further include a hydrophobic layer 411, and the hydrophobic layer 411 is formed on a surface of the microfluidic chip 120 for carrying the droplet. The hydrophobic layer 411 can prevent the liquid drop from penetrating into the microfluidic chip 120, reduce the loss of the liquid drop, and facilitate the movement of the liquid drop on the microfluidic chip 120. A hydrophobic layer 411 is located on the surface of the drive electrode 409 remote from the substrate base 401. The hydrophobic layer 411 may increase a surface tension gradient, thereby facilitating movement of a droplet on the microfluidic chip 120. The hydrophobic layer 411 may be directly formed on the surface of the driving electrode 409, or an insulating layer 410 may be further formed between the hydrophobic layer 411 and the driving electrode 409, whereby the driving electrode 409 may be electrically insulated from the droplet. The insulating layer 410 may also function as a flat layer so that the driving substrate 110 has a flat surface. In some exemplary embodiments, the hydrophobic layer 411 may be formed by teflon (teflon),
(1-butenylvinylether) polymer), the insulating layer 410 may be formed of an inorganic insulating material or an organic insulating material, for example, a resin, but the embodiment of the present disclosure is not limited thereto.
In addition, the microfluidic chip 120 may further include a controller, a gate driving circuit, and a data driving circuit. The controller is coupled to the gate driving circuit and the data driving circuit, receives an input signal, and provides a timing signal, a driving signal, etc. to the gate driving circuit and the data driving circuit according to the input signal, so as to control the gate driving circuit and the data driving circuit to work synchronously. The gate driving circuit may apply a scan signal to the driving array, for example, row by row, through the gate lines to control the switching elements to be turned on or off, and the data driving circuit may apply a driving signal to the driving array through the data lines. The gate of the switching element of each driving unit 1222 is electrically connected to the gate line corresponding to the row of the driving unit, and the first pole 405 of the switching element is electrically connected to the data line of the column of the driving unit, so as to be electrically connected to the data driving circuit to receive the driving signal, so that the driving signal can be provided to the driving electrode 409 when the switching element is turned on. The micro fluidic chip 120 may further include a port part connected with an external signal through, for example, a flexible circuit board to receive an input signal (control signal) and provide the input signal to a controller of the micro fluidic chip 120 to generate corresponding signals for the gate driving circuit and the data driving circuit.
It should be understood that the microfluidic chip 120 shown in fig. 3 and 4 is merely exemplary, and the embodiments of the present disclosure are not limited thereto.
In at least one embodiment of the present disclosure, the microfluidic device 100 may further include a control device 130. The control device 130 is in signal connection with the touch panel 110 and the microfluidic chip 120 to generate a control signal for controlling the microfluidic chip 120 according to the detection signal provided by the touch panel 110 to perform a preset operation on the target droplet.
As shown in fig. 5, the control device 130 may include: a first interface 1311, a controller 1312, and a second interface 1313. The first interface 1311 is configured to be in signal connection with the touch panel 110, the second interface 1313 is configured to be in signal connection with the microfluidic chip 120, and the controller 1312 is configured to obtain a detection result of a contact action of the touch panel 110 on the touch surface of the touch panel 110, and control the microfluidic chip 120 to perform a preset operation on a target droplet according to the detection result. The first interface 1311 may be electrically connected to the port region B of the touch panel 110 shown in fig. 2 through, for example, a flexible circuit board, to receive a touch signal; the second interface 1313 may be electrically connected to the port region of the micro-fluidic chip 120 through, for example, a flexible circuit board, so as to transmit an input signal required by the micro-fluidic chip 120, so that a driving signal may be provided to the first pole 405 of the switching element of a corresponding driving unit in the driving array of the micro-fluidic chip 120, that is, a driving signal may be provided to the driving electrode 409 of the driving unit, so as to perform a driving operation corresponding to the touch signal on the droplet.
The first interface 1311 may be configured to be coupled to the touch panel 110 directly or indirectly through a network (e.g., the internet, a wireless LAN, etc.) to receive a touch signal. The second interface 1313 may be configured to couple to the microfluidic chip 120 directly or indirectly through a network (e.g., the internet, wireless LAN, etc.) to provide the driving signals to the microfluidic chip 120. For example, in some embodiments, the first interface 1311 and the second interface 1313 may be I 2 A C (Inter-Integrated Circuit) Interface, an SPI (Serial Peripheral Interface) Interface, or a Universal Serial Bus (USB) Interface, etc., however, it should be understood that the embodiments of the present disclosure are not limited thereto.
In some embodiments, any two of the control device 130, the touch panel 110, and the microfluidic chip 120 are removably connected to facilitate maintenance and replacement of the microfluidic device. However, it should be understood that any two of the control device 130, the touch panel 110 and the microfluidic chip 120 may also be fixedly connected, and the embodiment of the disclosure is not limited thereto. For example, in some embodiments, the touch panel 110 and the microfluidic chip 120 may be connected by a detachable fastening device, such as a snap-fit fastening device or a magnetic-attraction fastening device. In other embodiments, the touch panel 110 and the microfluidic chip 120 may be fixedly connected by an adhesive or the like. The detachable connection between the control device 130 and the touch panel 110 and/or the microfluidic chip 120 may be realized by a plug and a socket, for example.
The controller 1312 may include, for example, a Field Programmable Gate Array (FPGA), a program specific integrated circuit (ASIC), a program specific standard product (ASSP), a system on a chip (SOC), a Complex Programmable Logic Device (CPLD), a Digital Signal Processor (DSP), etc., which are not limited thereto by the embodiments of the present disclosure. The controller 1312 may be connected to the first interface 1311 and the second interface 1313 via a bus, for example, for signal connection.
The controller 1312 may be further configured to plan a movement route of the target droplet in the microfluidic chip 120 or on the microfluidic chip 120 according to a contact action on the touch surface of the touch panel 110, and control the microfluidic chip 120 to drive the target droplet to move according to the movement route.
For example, controller 1312 may be configured to: in the case where the contact action is a click action, a droplet located at a corresponding position on the microfluidic chip 120 where the click action occurs is determined as a target droplet and a preset operation is performed on the selected target droplet.
For example, controller 1312 may be configured to: in the case that the contact action is a sliding action starting from a first position on the touch panel 110 and continuing to a second position on the touch panel 110, determining a droplet located at the first position at a corresponding position on the microfluidic chip 120 as a target droplet, identifying a trajectory of the sliding action and planning a movement route of the target droplet according to the trajectory, and controlling the microfluidic chip 120 to drive the target droplet to move according to the planned movement route. For example, the controller 1312 may be configured to route the movement of the target droplet to the trajectory of the gliding action, such that the target droplet moves along the trajectory of the gliding action. In addition, the controller 1312 may be further configured to control the microfluidic chip 120 such that the target droplet moves at the speed of the sliding motion.
Fig. 6 is a schematic diagram of an example of a trace of a contact action on a touch panel according to at least one embodiment of the present disclosure, in which exemplary droplets D1-D4 in or on the microfluidic chip 120 and a driving unit 1222 of the microfluidic chip 120 are also shown for convenience of description. As shown in fig. 6, the sliding motion starts from the first position P1 on the touch panel 110 and continues to the second position P2 on the touch panel 110, and the controller 1312 may be configured to determine the droplet D1 located at the corresponding position of the first position P1 on the microfluidic chip 120 as a target droplet, recognize the trajectory T of the sliding motion, and control the microfluidic chip 120 to drive the droplet S1 to move according to the trajectory T.
For example, controller 1312 may be configured to: in the case that the contact action is a sliding action starting from a first position on the touch panel 110 and continuing to a second position on the touch panel 110, a droplet located on a corresponding trajectory of the sliding action on the microfluidic chip is determined as a target droplet, the trajectory of the sliding action is identified and a motion route of the target droplet is planned according to the trajectory, and the microfluidic chip 120 is controlled to drive the target droplet to move according to the planned motion route. For example, the controller 1312 may be configured to route the movement of the target droplet to the trajectory of the gliding action, such that the target droplet moves along the trajectory of the gliding action. In addition, the controller 1312 may be further configured to control the microfluidic chip 120 such that the target droplet moves at the speed of the sliding motion. As shown in fig. 6, the sliding motion starts to contact from the first position P1 on the touch panel 110 and continues to the second position P2 on the touch panel 110, the controller 1312 may be configured to determine droplets D1 to D4 located on corresponding tracks of the track T of the sliding motion on the microfluidic chip 120 as target droplets, and control the microfluidic chip 120 to drive the droplets D1 to D4 to move according to the track T.
It should be understood that other contact actions may be predefined according to actual requirements to perform various preset operations on the target droplets, and the embodiments of the present disclosure are not limited thereto.
In some embodiments, the droplets within the operating region of the microfluidic chip 120 may include droplets of various reagents (e.g., diluents, dyes, etc.) in addition to the droplets of the liquid to be detected, so that the droplets of the liquid to be detected may be mixed with the reagents for subsequent analysis and detection.
As shown in fig. 7, in at least one embodiment of the present disclosure, the controller 1312 may include a system on chip (SoC)13121 in signal connection with the first interface 1311 and a Micro Control Unit (MCU)131122 in signal connection with the second interface 1312. The on-chip system 13121 is configured to process the touch signal received by the first interface 1311 to determine touch information, where the touch information includes, but is not limited to, position information of the contact action on the touch panel 110, pressing strength information of the contact action on the touch panel 110, duration information of the contact action on the touch panel 110, and the like. The micro control unit 13122 is configured to generate and output a driving signal for the micro fluidic chip according to the touch information provided by the system on chip 13121.
In some embodiments, the control device 130 can be disposed on a flexible circuit board (FPC), for example, to reduce the volume of the microfluidic device 100.
Fig. 8 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure. As shown in fig. 8, the microfluidic device 200 according to at least one embodiment of the present disclosure may further include a display panel 140 on the basis of the microfluidic device 100 shown in fig. 1. The display panel 140 is used to display a target droplet on the microfluidic chip 120 or in the microfluidic chip 120, and the display panel 140 is disposed such that the touch panel 110 is located on the display side of the display panel 140. The display panel 140 may include, for example, a liquid crystal display panel, an organic light emitting diode display panel, an electronic paper display panel, and the like, which are not limited in this respect by the embodiments of the present disclosure.
The display area of the display panel 140 may display liquid droplets in the operation area of the microfluidic chip 130, and the detection area of the touch panel 110 may overlap with the display area of the display panel 140 while corresponding to the operation area of the microfluidic chip 130, for example, in a similar relationship in shape, so that a point in the detection area of the touch panel 110 geometrically corresponds to a point in the operation area of the microfluidic chip 130 in a one-to-one relationship.
In the microfluidic device 200, the microfluidic chip 130 is configured to perform the preset operation on the target droplet displayed on the display panel 140 according to the operation of the contact on the touch surface of the touch panel 110.
In some embodiments, the display panel 140 may magnify the droplets in the operation region of the microfluidic chip 130, so that the droplets can be more accurately operated.
In other embodiments, such as where the microfluidic chip 130 is in an environment that is not suitable for human access, such as a high temperature environment or a dust-free environment, the touch panel 110 and the display panel 140 may be disposed separately from the microfluidic chip 130, so that the droplets in the microfluidic chip 130 or on the microfluidic chip 130 may be remotely operated.
As shown in fig. 8, in some embodiments, the display panel 140 may be in signal connection with the control device 130 (e.g., the wired connection shown in fig. 8) so as to perform display under the control of the control device 130, for example, the display panel 140 may receive signals such as an on signal, an off signal, a data signal of an image of the microfluidic chip 130 to be displayed, and the like from the control device 130. However, it should be understood that the display panel 140 may also be not connected to the control device 130, but connected to other control devices separately provided for receiving signals such as an on signal, an off signal, a data signal of an image of the microfluidic chip 120 to be displayed, and the like, and the embodiment of the present disclosure is not limited thereto.
Fig. 9 is a schematic block diagram of a microfluidic device according to at least one embodiment of the present disclosure. As shown in fig. 9, a microfluidic device 300 according to at least one embodiment of the present disclosure may further include an image acquisition device 150 on the basis of the microfluidic device 200 shown in fig. 8. The image capturing device 150 is configured to capture image information of the target droplet on the microfluidic chip 120 or in the microfluidic chip 120 and provide the image information of the target droplet to the control device 130, the control device 130 transmits the image information to the display panel 140 after performing necessary processing on the image information, and the display panel 140 is configured to display the target droplet based on the image information of the target droplet. In some embodiments, the image capture device 150 can be configured to capture an image of the operating region of the microfluidic chip 120 to obtain droplet image information within the operating region of the microfluidic chip 120. The image capturing device 150 may include, for example, a camera or the like, and the embodiment of the present disclosure is not limited thereto.
As shown in fig. 9, in some embodiments, the image capturing device 150 may be in signal connection with the control device 130 (e.g., the wired connection shown in fig. 9) so that an image of a target droplet on or in the microfluidic chip 120 may be captured under the control of the control device 130, for example, the image capturing device 150 may receive a turn-on signal, a control signal instructing the image capturing device 150 to capture an image, and the like from the control device 130, and the image capturing device 150 may transmit a data signal of the captured image to the control device 130, so that the control device 130 may process (e.g., identify, filter, denoise, and the like) the data signal and transmit the processed data signal to the display panel 140. However, it should be understood that the image capturing device 150 may not be connected to the control device 130, but may be connected to other control devices separately provided for receiving signals, such as a turn-on signal, a control signal instructing the image capturing device 150 to capture an image, and the like, and the embodiment of the disclosure is not limited thereto. In some embodiments, the image capturing device 150 may also be directly connected to the display panel 140 for directly transmitting the data signal of the captured image to the display panel 140, which is not limited by the embodiments of the present disclosure.
According to the micro-fluidic device disclosed by at least one embodiment of the disclosure, the micro-fluidic chip can be controlled through the touch panel to operate the liquid to be detected, so that the interactivity and the operability are improved.
At least one embodiment of the present disclosure also provides a method of operating a microfluidic device, which may be implemented in a microfluidic device according to any of the embodiments described above. As shown in fig. 10, a method 1000 of operation for a microfluidic device according to at least one embodiment of the present disclosure may include:
s1200, detecting a contact action on a touch surface of the touch panel through the touch panel; and
and S1400, executing preset operation on the target liquid drop through the micro-fluidic chip according to the detected contact action.
In some embodiments, the microfluidic device may further comprise a display panel, wherein the display panel is for displaying the target droplet, wherein the target droplet is on or in the microfluidic chip.
In the case where the microfluidic device includes a display panel, the method may further include: displaying the target droplets through the display panel, and the step S940 may include: and performing preset operation on the target liquid drop displayed on the display panel through the micro-fluidic chip according to the operation of the contact action on the target liquid drop.
In some embodiments, the microfluidic device may further include an image acquisition device, wherein the image acquisition device is configured to acquire image information of the target droplet on or in the microfluidic chip and provide the image information of the target droplet to the display panel, so that the display panel displays the target droplet based on the image information of the target droplet.
In the case where the microfluidic device includes an image capture device, the displaying the target droplet through the display panel may include: acquiring image information of the target liquid drops through an image acquisition device, and transmitting the image information of the target liquid drops to a display panel; and displaying the target droplet based on the image information of the target droplet through the display panel.
In some embodiments, the microfluidic device may further comprise a control device, wherein the control device is in signal connection with the touch panel and the microfluidic chip. The control device can receive a detection result of a contact action of the touch panel on the touch surface of the touch panel, and generate an input signal required for controlling the microfluidic chip based on the detection result, so that a driving signal can be provided to the first pole of the switching element of the corresponding driving unit in the driving array of the microfluidic chip, that is, the driving signal can be provided to the driving electrode of the driving unit, and the liquid drop is driven according to the touch signal. In the case where the microfluidic device includes a controller, the step S1400 may include: and in response to the contact action detected by the touch panel, controlling the microfluidic chip by the controller to execute preset operation on the target liquid drop according to the detected contact action.
For example, in some embodiments, the contact action on the touch surface of the touch panel described above may comprise a click action, and the method may comprise: and determining the liquid drop at the corresponding position of the occurrence position of the clicking action on the microfluidic chip as the target liquid drop.
For example, in some embodiments, the contact actions on the touch surface of the touch panel may include: the sliding motion is initiated from a first location on the touch panel and continues to a second location on the touch panel, and the method may include: and determining the liquid drop on the corresponding track of the sliding motion on the microfluidic chip as the target liquid drop.
It should be understood that other contact actions may be predefined according to actual requirements to perform various preset operations on the target droplets, and the embodiments of the present disclosure are not limited thereto.
The preset operations may include, but are not limited to: moving the target droplets, separating the target droplets, polymerizing the target droplets, applying a voltage to the target droplets, heating the target droplets, and the like, which are not limited by the embodiments of the present disclosure.
In some embodiments of the present disclosure, the step S1400 may include: and planning a movement route of the target liquid drop according to the sliding motion track detected by the touch panel, and controlling the micro-fluidic chip to drive the target liquid drop to move according to the movement route.
Therefore, the movement route of the target liquid drop can be planned according to the contact action of the user, so that the target liquid drop moves according to the contact action of the user. The detailed description of this step can be found in the description of the embodiments of the microfluidic device above, and will not be repeated here.
According to the operation method for the micro-fluidic device, the micro-fluidic chip can be controlled through the touch panel to operate the liquid to be detected, and interactivity and operability are improved.
The above description is only a specific embodiment of the present disclosure, but the scope of the present disclosure is not limited thereto, and the scope of the present disclosure should be subject to the scope of the claims.
Claims (12)
1. A microfluidic device comprising:
the touch panel is used for detecting a contact action on a touch surface of the touch panel; and
a microfluidic chip for performing a preset operation on the target droplet according to the detected contact action,
wherein the target droplets comprise droplets to be detected or droplets of a detection reagent,
the microfluidic chip comprises a plurality of driving units distributed in an array, wherein each driving unit comprises a driving electrode; the micro-fluidic device further comprises a control device, wherein the control device receives a touch signal provided by the touch panel and provides a driving signal for the driving electrode, so that the driving electrode performs a driving operation corresponding to the touch signal on the liquid drop;
the detection area of the touch panel is at least partially transparent so that the operational area of the microfluidic chip on the back side of the touch panel is visible.
2. The microfluidic device according to claim 1, further comprising a controller, wherein the controller is in signal connection with the touch panel and the microfluidic chip and is configured to control the microfluidic chip to perform the preset operation on the target droplet in response to the contact action detected by the touch panel.
3. The microfluidic device according to claim 2,
the controller is further used for planning a movement route of the target liquid drop according to the contact action and controlling the microfluidic chip to drive the target liquid drop to move according to the movement route.
4. The microfluidic device according to claim 2,
any two of the touch panel, the microfluidic chip and the controller are detachably connected.
5. The microfluidic device according to claim 1,
the detection area of the touch panel corresponds to the operation area of the microfluidic chip.
6. A control device, comprising: a controller, a first interface and a second interface, wherein the first interface is configured to be in signal connection with a touch panel, the second interface is configured to be in signal connection with a microfluidic chip, a detection area of the touch panel is at least partially transparent so that an operation area of the microfluidic chip located at a back side of the touch panel is visible, the microfluidic chip comprises a plurality of driving units distributed in an array, each driving unit comprises a driving electrode,
the controller is configured to acquire a detection result of the touch panel on the contact action, control the micro-fluidic chip to execute preset operation on the target liquid drop according to the detection result,
wherein the target droplets comprise droplets to be detected or droplets of a detection reagent,
the controller is further configured to receive a touch signal provided by the touch panel and provide a driving signal to the driving electrode so that the driving electrode performs a driving operation corresponding to the touch signal on the liquid drop.
7. A method of operation for a microfluidic device comprising a touch panel, a microfluidic chip and a control device, the touch panel having a detection area that is at least partially transparent such that an operational area of the microfluidic chip on a back side of the touch panel is visible, the microfluidic chip comprising a plurality of drive units distributed in an array, each drive unit comprising a drive electrode, the method comprising:
detecting a contact action on a touch surface of the touch panel through the touch panel; and
executing preset operation on the target liquid drop through the microfluidic chip according to the detected contact action,
wherein the target droplet comprises a droplet to be detected or a droplet of a detection reagent;
the step of performing a preset operation on the target droplet by the microfluidic chip according to the detected contact action further includes: and receiving a touch signal provided by the touch panel through the control device and providing a driving signal to the driving electrode so that the driving electrode performs a driving operation corresponding to the touch signal on the liquid drop.
8. The method of claim 7, wherein,
the control device comprises a controller which is in signal connection with the touch panel and the microfluidic chip, an
The performing, by the microfluidic chip, the preset operation on the target droplet according to the detected contact includes: in response to the contact action detected by the touch panel, controlling the microfluidic chip by the controller to perform the preset operation on the target liquid drop according to the detected contact action.
9. The method of claim 8, wherein the preset operation comprises at least one of: moving, separating, polymerizing, applying voltage, and heating.
10. The method of claim 7, wherein,
the contact action includes a click action, an
The target liquid drop is a liquid drop which is positioned at a corresponding position of the occurrence position of the clicking action on the microfluidic chip.
11. The method of claim 7, wherein,
the contact action comprises: a swiping motion starting from a first location on the touch panel and continuing to a second location on the touch panel, an
The target liquid drop is a liquid drop positioned on a corresponding track of the sliding action on the microfluidic chip.
12. The method of claim 11, wherein,
the step of performing a preset operation on the target droplet by the microfluidic chip according to the detected contact action includes:
and planning a movement route of the target liquid drop according to the sliding motion track detected by the touch panel, and controlling the microfluidic chip to drive the target liquid drop to move according to the movement route.
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| CN201910368331.3A CN110069168B (en) | 2019-05-05 | 2019-05-05 | Microfluidic device, operating method for microfluidic device and control device |
| PCT/CN2020/079596 WO2020224330A1 (en) | 2019-05-05 | 2020-03-17 | Microfluidic device, operation method for microfluidic device, and control device |
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| CN110441940B (en) * | 2019-08-01 | 2022-07-19 | 上海闻泰信息技术有限公司 | Manufacturing method of display panel, display panel and display device |
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