CN110064116B - High-precision flow control valve for airflow control respirator - Google Patents

High-precision flow control valve for airflow control respirator Download PDF

Info

Publication number
CN110064116B
CN110064116B CN201910495786.1A CN201910495786A CN110064116B CN 110064116 B CN110064116 B CN 110064116B CN 201910495786 A CN201910495786 A CN 201910495786A CN 110064116 B CN110064116 B CN 110064116B
Authority
CN
China
Prior art keywords
valve body
elastic sealing
flow control
valve
sealing plates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201910495786.1A
Other languages
Chinese (zh)
Other versions
CN110064116A (en
Inventor
王智刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Peoples Hospital of Changzhou
Original Assignee
First Peoples Hospital of Changzhou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Peoples Hospital of Changzhou filed Critical First Peoples Hospital of Changzhou
Priority to CN201910495786.1A priority Critical patent/CN110064116B/en
Publication of CN110064116A publication Critical patent/CN110064116A/en
Application granted granted Critical
Publication of CN110064116B publication Critical patent/CN110064116B/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/20Valves specially adapted to medical respiratory devices
    • A61M16/201Controlled valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3334Measuring or controlling the flow rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/75General characteristics of the apparatus with filters

Abstract

The invention relates to the technical field of valves, in particular to a flow control valve for a high-precision airflow control respirator, which comprises a first valve body and a second valve body, wherein one end of the first valve body is plugged by a flow plate, at least three elastic sealing plates are arranged between the first valve body and the second valve body, when elastic deformation does not occur, the flow area between the first valve body and the second valve body is completely plugged, when deformation occurs, different flow areas are realized according to the deformation degree, an annular inflation body is arranged on one side, close to the elastic sealing plates, of the flow plate and used for supporting the elastic sealing plates, the annular inflation body is inflated by gas in the respirator, a power plate with an air outlet hole is arranged at the other end of the second valve body, a plurality of springs connected with the elastic sealing plates are arranged on the power plate, and the power plate moves under the driving of a servo motor. The invention can overcome the problems of high control precision and control difficulty of the respirator in the prior art.

Description

High-precision flow control valve for airflow control respirator
Technical Field
The invention relates to the technical field of valves, in particular to a flow control valve for a high-precision airflow control respirator.
Background
The breathing machine is a vital medical device which can prevent and treat respiratory failure, reduce complications and save and prolong the life of a patient. In modern clinical medicine, a ventilator has been widely used in respiratory failure due to various reasons, anesthesia and breathing management during major surgery, respiratory support therapy and emergency resuscitation as an effective means for manually replacing the function of spontaneous ventilation, and has a very important position in the modern medical field.
In the traditional breathing machine, the gas discharge area of the release port can not be adjusted, so that the control precision of the pressure and the flow of the breathing machine is low, the control difficulty is high, and the treatment effect of the breathing machine is seriously influenced.
In view of the above problems, the designer is based on the practical experience and professional knowledge that are abundant for many years in engineering application of such products, and is engaged with the application of the theory to actively make research and innovation, so as to create a high-precision flow control valve for controlling the breathing machine, and make the flow control valve more practical.
Disclosure of Invention
The invention aims to solve the problems of high control precision and control difficulty of the breathing machine in the prior art.
In order to achieve the purpose, the invention adopts the technical scheme that:
a flow control valve for a high-precision airflow control respirator is arranged on one port of a three-way pipeline, and the other two ports of the three-way pipeline are used for air inlet and air outlet respectively;
the flow control valve comprises a first valve body and a second valve body which are hollow cylinders with equal outlines; one end of the first valve body is blocked by a flow passing plate provided with a flow passing hole, at least three elastic sealing plates are arranged between the first valve body and the second valve body, when the elastic sealing plates are not elastically deformed, the flow area between the first valve body and the second valve body is completely sealed, and when the valve body is deformed, different flow areas between the first valve body and the second valve body are realized according to the deformation degree, an annular inflatable body is arranged on one side of the flow passing plate close to the elastic sealing plate, used for supporting the elastic sealing plate and inflating the annular inflatable body through the gas in the respirator, the other end of the second valve body is provided with a power plate with an air outlet hole, the power plate is provided with a plurality of springs connected with the elastic sealing plates, the power plate moves under the driving of a servo motor, so that the flow control valve obtains different flow areas through the deformation of the elastic sealing plate.
Furthermore, one end of each elastic sealing plate is fixed between the first valve body and the second valve body in an extruding mode, and the staggered convex edges at the edges of every two adjacent elastic sealing plates are at least partially overlapped.
Furthermore, a plurality of overflowing holes are uniformly distributed along the circumference, and the distance between the circle center position of the overflowing holes and the outer wall of the first valve body is smaller than 1/6 of the outer diameter of the first valve body.
Furthermore, the circle center of the spring is superposed with the action part of the annular inflatable body on the elastic sealing plate.
Further, the air outlet is covered with a filter screen structure.
Furthermore, at least one strip-shaped protrusion/groove is arranged on the inner wall of the second valve body, a groove/strip-shaped protrusion matched with the strip-shaped protrusion/groove is arranged at the edge of the power plate, and the power plate is guided through the matching of the two protrusions/grooves.
Further, the side wall of the annular inflatable body is corrugated.
The flow control valve can realize accurate control of the gas discharge area, thereby obtaining a high-precision gas flow control scheme. Specifically, when the exhalation control is performed, a large gas release amount is needed, at the moment, the servo motor rotates forwards, the power plate is driven by the screw rod assembly to move towards one side away from the three-way pipeline, at the moment, the spring drives the elastic sealing plates to deform, so that a channel for gas to flow is formed between the elastic sealing plates, and meanwhile, in the deformation process of the elastic sealing plates, the elastic sealing plates are separated from the annular inflation body because the elastic sealing plates are not connected with the annular inflation body, the gas is released through the overflowing holes, gaps among the elastic sealing plates and the air outlet holes, and the specific release area can be accurately controlled according to the moving distance of the power plate driven by the servo motor; when the air suction control is carried out, the servo motor rotates reversely, the power plate is driven to move to one side close to the three-way pipeline through the screw rod assembly, the stretched spring is gradually recovered in the air suction process, and the servo motor receives a signal to stop rotating until the signal is abutted against the annular inflatable body, so that the air suction process is completed.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic view of the installation of a flow control valve and tee in the present invention;
FIGS. 2 and 3 are views of the flow control valve from different angles; (the first valve body includes and does not include external threads, respectively)
FIG. 4 is a schematic view of the flow control valve in the absence of deformation of the resilient sealing plate;
FIG. 5 is a schematic view of the flow control valve in the event of deformation of the resilient sealing plate (gas release);
FIG. 6 is a schematic view of the combination of the respective elastic sealing plates;
FIG. 7 is a cross-sectional view taken at A-A in FIG. 6;
reference numerals: the valve comprises a first valve body 1, a second valve body 2, a flow passing plate 3, a flow passing hole 31, an elastic sealing plate 4, an annular inflating body 5, a power plate 6, an air outlet hole 61, a spring 7, a servo motor 8 and a screw rod assembly 9.
Detailed Description
The invention is further described below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and the protection scope of the present invention is not limited thereby.
As shown in fig. 1 to 5, a flow control valve for a high-precision air flow control respirator is mounted on one port of a three-way pipeline, and the other two ports of the three-way pipeline are used for air inlet and air outlet respectively; the flow control valve comprises a first valve body 1 and a second valve body 2 which are hollow cylinders with equal outlines; one end of the first valve body 1 is blocked by a flow plate 3 provided with a flow hole 31, at least three elastic sealing plates 4 are arranged between the first valve body 1 and the second valve body 2, each elastic sealing plate 4 blocks the flow area between the first valve body 1 and the second valve body 2 when the elastic sealing plate 4 is not elastically deformed, and when the elastic sealing plate 4 is deformed, different flow areas between the first valve body 1 and the second valve body 2 are realized according to the deformation degree, an annular inflation body 5 is arranged on one side of the flow plate 3 close to the elastic sealing plate 4 and used for supporting the elastic sealing plate 4, the annular inflation body 5 is inflated by gas in a respirator, a power plate 6 provided with a gas outlet 61 is arranged at the other end of the second valve body 2, and a plurality of springs 7 connected with the elastic sealing plates 4 are arranged on the power plate 6, the power plate 6 moves under the driving of the servo motor 8, so that the flow control valve obtains different flow areas through the deformation of the elastic sealing plate 4.
The flow control valve can realize accurate control of the gas discharge area, thereby obtaining a high-precision gas flow control scheme. Specifically, when carrying out expiration control, need great gas release volume, servo motor 8 corotation this moment drives through lead screw subassembly 9 power plate 6 is to the one side motion of keeping away from the tee bend pipeline, at this moment, spring 7 drives elastic sealing plate 4 and takes place deformation for form the passageway that can supply the gas circulation between each elastic sealing plate 4, and at the in-process of elastic sealing plate 4 deformation simultaneously, because there is not being connected between elastic sealing plate 4 and the cyclic annular inflation body 5, therefore the two separates, and gas passes through discharge hole 31, gap between each elastic sealing plate 4 and venthole 61 release, and specific release area basis servo motor 8 drives the distance that power plate 6 removed can accurate control. When the air suction control is carried out, the servo motor 8 rotates reversely, the power plate 6 is driven to move towards one side close to the three-way pipeline through the screw rod assembly 9, the stretched spring 7 is gradually recovered in the air suction process until the stretched spring abuts against the annular inflatable body 5, the servo motor 8 receives a signal to stop rotating, the air suction process is finished, and the control signal of the servo motor 8 can be obtained through the torsion sensor.
In the invention, the annular inflatable body 5 can be filled by the gas in the respirator, so that a reliable supporting structure is formed, and meanwhile, as the annular inflatable body is an elastic body, when the spring 7 acts on the elastic sealing plate 4 locally, the annular inflatable body 5 and the elastic sealing plate 4 can be attached more tightly through the elastic deformation of the annular inflatable body 5, so that a better sealing effect is realized.
As a preferred embodiment, one end of the elastic sealing plate 4 is fixed between the first valve body 1 and the second valve body 2 by pressing, and as shown in fig. 6 and 7, the protruding edges arranged in a staggered manner between two adjacent elastic sealing plates 4 are partially overlapped, thereby ensuring the reliability of sealing. In the preferred scheme, when the elastic sealing plates 4 are not deformed, a complete circular structure is formed to block the flow passage, when the elastic sealing plates are deformed, one end of each elastic sealing plate is extruded by the first valve body 1 and the second valve body 2 without change, and the other end of each elastic sealing plate is relatively expanded to form a gap due to the pulling of the spring 7; first valve body 1 with the second valve body 2 accessible link up the screw of second valve body 2 is realized fixed, convenient and fast, when installing whole flow control valve, the accessible set up in screw tightening is realized to the outside external screw thread of first valve body 1. When the material of the elastic sealing plate 4 is selected, a conventional rubber material may be selected, and other materials having elasticity may be selected.
Preferably, a plurality of overflowing holes 31 are uniformly distributed along the circumference, and the distance between the circle center position of the overflowing holes 31 and the outer wall of the first valve body 1 is smaller than 1/6 of the outer diameter of the first valve body 1. In the whole working process of the respirator, besides the action of the servo motor 8, the gas in the pipeline also applies force to the elastic sealing plate 4 through the overflowing hole 31, and in order to reduce the influence of the force on the elastic sealing plate 4, the overflowing hole 31 is arranged close to the outer wall of the first valve body 1, so that the length of the force arm can be reduced, and the required purpose is achieved.
As a preferred choice of the above embodiment, the center of the spring 7 coincides with the action position of the annular inflatable body 5 on the elastic sealing plate 4, so as to reduce the deformation rate of the elastic sealing plate 4, and the relative centralized action point also enables the control to be more accurate, in order to ensure the uniform support of the annular inflatable body 5, a plurality of inflation ports can be arranged on the filtering plate 3 to inflate the annular inflatable body 5, and the inflation ports are uniformly distributed, specifically, a plurality of annular protrusions are arranged on the annular inflatable body 5, and the annular protrusions are inserted into the inflation ports to realize the fixation thereof.
In the specific implementation process, the air outlet 61 is covered with a filter screen structure, so that the influence on the gas quality caused by the entering of impurities is avoided.
At the in-process that drives the motion of lead screw subassembly 9 through servo motor 8, be provided with at least one bar arch/recess on the inner wall of second valve body 2, the edge of power board 6 is provided with the recess/bar arch that the protruding/recess of bar matches realizes through the cooperation of the two the direction of power board 6 servo motor 8 drives through lead screw subassembly 9 the in-process of power board 6 motion can avoid the rotation of power board 6 also makes control more accurate through the direction simultaneously.
When the annular gas-filled body 5 is selected, a structure in which the outside is corrugated can be selected, so that the directionality of deformation caused by gas filling is more determined, and the deformation rate can be improved under the same volume, thereby ensuring the sealing effect.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (7)

1. A flow control valve for a high-precision airflow control respirator is arranged on one port of a three-way pipeline, and the other two ports of the three-way pipeline are used for air inlet and air outlet respectively; it is characterized in that the preparation method is characterized in that,
the flow control valve comprises a first valve body (1) and a second valve body (2), wherein the first valve body and the second valve body are hollow cylinders with equal outlines; one end of the first valve body (1) is plugged by an overflowing plate (3) provided with an overflowing hole (31), at least three elastic sealing plates (4) are arranged between the first valve body (1) and the second valve body (2), when elastic deformation does not occur, the elastic sealing plates (4) plug the overflowing areas between the first valve body (1) and the second valve body (2) completely, when deformation occurs, different overflowing areas between the first valve body (1) and the second valve body (2) are realized according to the deformation degree, one side, close to the elastic sealing plates (4), of the overflowing plate (3) is provided with an annular inflating body (5) for supporting the elastic sealing plates (4) and inflating the annular inflating body (5) by gas in a respirator, the other end of the second valve body (2) is provided with a power plate (6) provided with an air outlet hole (61), the flow control valve is characterized in that a plurality of springs (7) connected with the elastic sealing plates (4) are arranged on the power plate (6), the power plate (6) moves under the driving of a servo motor (8), and therefore the flow control valve obtains different flow areas through the deformation of the elastic sealing plates (4).
2. The flow control valve for the high-precision airflow control respirator according to claim 1, characterized in that one end of the elastic sealing plate (4) is fixed between the first valve body (1) and the second valve body (2) in a pressing way, and the dislocated convex edges at the edges of two adjacent elastic sealing plates (4) are at least partially overlapped.
3. The flow control valve for the high-precision airflow control respirator according to claim 1, characterized in that a plurality of overflowing holes (31) are uniformly distributed along the circumference, and the distance between the circle center position of the overflowing hole (31) and the outer wall of the first valve body (1) is smaller than 1/6 of the outer diameter of the first valve body (1).
4. The flow control valve for a high-precision air flow control respirator according to claim 1, characterized in that the center of the spring (7) coincides with the position of action of the annular gas-filled body (5) on the elastic sealing plate (4).
5. A flow control valve for a high precision air flow control ventilator according to claim 1, characterized in that the air outlet holes (61) are covered with a filter mesh structure.
6. The flow control valve for the high-precision airflow control respirator according to claim 1, characterized in that the inner wall of the second valve body (2) is provided with at least one strip-shaped protrusion/groove, the edge of the power plate (6) is provided with a groove/strip-shaped protrusion matched with the strip-shaped protrusion/groove, and the guiding of the power plate (6) is realized through the matching of the two.
7. A flow control valve for a highly accurate airflow control ventilator according to claim 1, characterized in that the side wall of the annular gas-filled body (5) is corrugated.
CN201910495786.1A 2019-06-10 2019-06-10 High-precision flow control valve for airflow control respirator Expired - Fee Related CN110064116B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910495786.1A CN110064116B (en) 2019-06-10 2019-06-10 High-precision flow control valve for airflow control respirator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910495786.1A CN110064116B (en) 2019-06-10 2019-06-10 High-precision flow control valve for airflow control respirator

Publications (2)

Publication Number Publication Date
CN110064116A CN110064116A (en) 2019-07-30
CN110064116B true CN110064116B (en) 2020-02-21

Family

ID=67372798

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910495786.1A Expired - Fee Related CN110064116B (en) 2019-06-10 2019-06-10 High-precision flow control valve for airflow control respirator

Country Status (1)

Country Link
CN (1) CN110064116B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115192847B (en) * 2022-07-07 2023-09-08 南通大学附属医院 Buccal intelligent constant temperature humidifier

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3556122A (en) * 1964-06-15 1971-01-19 Laerdal A S Valve for artificial respiration apparatus
US4823828A (en) * 1987-05-28 1989-04-25 Mcginnis Gerald E Pressure relief valve
WO1997009552A1 (en) * 1995-09-01 1997-03-13 Varioraw Percutive S.A. Valve
CN201921250U (en) * 2010-09-26 2011-08-10 深圳市百格医疗技术有限公司 Active respiration control device for anesthesia respirator
CN102500030A (en) * 2011-10-13 2012-06-20 苏州凯迪泰医学科技有限公司 Electromagnetically controlled tee-joint flow valve and medical breathing machine
CN103185163A (en) * 2011-12-30 2013-07-03 北京谊安医疗系统股份有限公司 Flow control proportioning valve
CN206424395U (en) * 2016-10-24 2017-08-22 湖南万脉医疗科技有限公司 A kind of high-accuracy ventilation flow rate control system and medical breathing machine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3556122A (en) * 1964-06-15 1971-01-19 Laerdal A S Valve for artificial respiration apparatus
US4823828A (en) * 1987-05-28 1989-04-25 Mcginnis Gerald E Pressure relief valve
WO1997009552A1 (en) * 1995-09-01 1997-03-13 Varioraw Percutive S.A. Valve
CN201921250U (en) * 2010-09-26 2011-08-10 深圳市百格医疗技术有限公司 Active respiration control device for anesthesia respirator
CN102500030A (en) * 2011-10-13 2012-06-20 苏州凯迪泰医学科技有限公司 Electromagnetically controlled tee-joint flow valve and medical breathing machine
CN103185163A (en) * 2011-12-30 2013-07-03 北京谊安医疗系统股份有限公司 Flow control proportioning valve
CN206424395U (en) * 2016-10-24 2017-08-22 湖南万脉医疗科技有限公司 A kind of high-accuracy ventilation flow rate control system and medical breathing machine

Also Published As

Publication number Publication date
CN110064116A (en) 2019-07-30

Similar Documents

Publication Publication Date Title
US11420009B2 (en) Valve with internal member
US8051855B2 (en) Respiratory mask
CN101405047B (en) Device for introducing breathing gas directly in the nose of a user
CN109045371B (en) Internal effusion pressure-stabilizing drainage device for operation
CN110064116B (en) High-precision flow control valve for airflow control respirator
EP2744551B1 (en) Cushion with selectively variable softness/stiffness
US4850349A (en) Endotracheal tube sealing cuff system
EP2750747B1 (en) Patient interface device with nose bridge adjustment
WO2014091360A1 (en) Mask with red mark alleviating pocket
US9610418B2 (en) Patient interface device including a pneumatically adjusting forehead support
CN109125871B (en) Trachea cannula device capable of automatically regulating air pressure of air bag through sound control
CN110064115B (en) Frequency regulating valve for breathing machine
CN207804735U (en) Medical throat cover
CN210521509U (en) Laryngeal mask utricule and contain laryngeal mask of this laryngeal mask utricule
CN208959046U (en) Guide device of endotracheal tube
US9821132B2 (en) Patient interface device including an adjustable forehead support having a vertical wheel drive mechanism
WO2021098192A1 (en) Proportional valve and ventilator
WO2016034970A1 (en) Nasal pillow patient interface including the same
CN211935110U (en) Automatic inflating and pneumatic controlling type tracheal catheter for cuff
CN216022575U (en) Breathing mask capable of passing through stomach tube
CN209638463U (en) A kind of aerated pressure maintaining gas nozzle
CN219167392U (en) Autogenous cutting sleeve pipe plugging device of adjustable shutoff area
CN112206390B (en) Tracheotomy intubation oxygen connecting pipe
CN211188654U (en) Tracheal catheter guiding device
CN113694336A (en) Tracheal intubation cuff pressure control device and implementation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20200221

Termination date: 20210610

CF01 Termination of patent right due to non-payment of annual fee