CN110063710A - A kind of method of determining scleral spur - Google Patents
A kind of method of determining scleral spur Download PDFInfo
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- CN110063710A CN110063710A CN201910204642.6A CN201910204642A CN110063710A CN 110063710 A CN110063710 A CN 110063710A CN 201910204642 A CN201910204642 A CN 201910204642A CN 110063710 A CN110063710 A CN 110063710A
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- 238000000034 method Methods 0.000 title claims abstract description 27
- 210000004087 cornea Anatomy 0.000 claims abstract description 99
- 210000003786 sclera Anatomy 0.000 claims description 4
- 238000010586 diagram Methods 0.000 description 13
- 238000012014 optical coherence tomography Methods 0.000 description 7
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000000554 iris Anatomy 0.000 description 1
- 210000001232 limbus corneae Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- G—PHYSICS
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/10—Segmentation; Edge detection
- G06T7/13—Edge detection
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10072—Tomographic images
- G06T2207/10101—Optical tomography; Optical coherence tomography [OCT]
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
- G06T2207/30041—Eye; Retina; Ophthalmic
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Abstract
The present invention provides a kind of method of determining scleral spur, includes the following steps: to acquire anterior ocular segment cornea image using near infrared light；The contour line of the upper surface of cornea is determined by the anterior ocular segment cornea image；Refractive correction is carried out to the contour line of upper surface described in anterior ocular segment cornea image point below and obtains the real image of cornea；Iris and cornea are determined in the real image of the cornea；The position of scleral spur is determined according to the position of the iris.Anterior ocular segment cornea image is acquired by near infrared light, and image is further processed, the position of scleral spur is determined according to the position of iris, can accomplish the integrated measuring of anterior ocular segment oculi posterior segment, saves cost.
Description
Technical field
The present invention relates to optical coherence tomography field more particularly to a kind of methods of determining scleral spur.
Background technique
Optical coherence tomography (Optical coherence tomograph, OCT) is a kind of based on low coherence interference
Non-invasive medical imaging means, anterior ocular segment OCT non-contact, real-time can provide dynamic clear part ocular anterior segment structure figure
Picture, can be used for diagnosing cornea, sclera, iris, room angle abnormality, thus to diagnose the common eye such as glaucoma, cataract
Section's disease.
The field OCT mainly carries out eyeground and angle with the light of 1310nm (far red light) and 840nm (near infrared light) at present
The imaging of film.Generally speaking, prosthomere cornea can be more clearly imaged in the light of 1310nm, can measure the true of room angle well
Truth condition, however the truth on eyeground cannot be but measured well.The light of 840nm can but do fundus imaging well, so
And true room angle cannot be measured very well.Currently, OCT equipment often can only be single acquisition anterior ocular segment or oculi posterior segment figure
Picture, or be imaged respectively by the method for switchable optics system.Near-infrared is used main reasons is that lacking in the prior art
The method that light determines scleral spur.
Summary of the invention
The present invention in order to solve the existing problems, provides a kind of method of determining scleral spur.
To solve the above-mentioned problems, the technical solution adopted by the present invention is as described below:
A kind of method of determining scleral spur, includes the following steps: S1: acquiring anterior ocular segment cornea figure using near infrared light
Picture；S2: the contour line of the upper surface of cornea is determined by the anterior ocular segment cornea image；S3: to the anterior ocular segment cornea image
Described in the contour line point below of upper surface carry out refractive correction and obtain the real image of cornea；S4: in the reality of the cornea
Iris and cornea are determined in the image of border；S5: the position of scleral spur is determined according to the position of the iris.
Preferably, the wavelength of the near infrared light is 790nm-890nm.
Preferably, S21 is included the following steps: in the step S2: choosing gray value threshold value to the anterior ocular segment cornea figure
As carrying out two points of processing, bipartite graph picture is obtained；S22: connected region processing is carried out to the bipartite graph picture, determines the upper table of cornea
The partial contour line in face；S23: being fitted the point of the partial contour line, obtains the integrity profile line of the upper surface of cornea.
Preferably, the gray value chosen in the step S21 is 20-30.
It preferably, include: to carry out 2 fittings to the point of the partial contour line to obtain parabola in step S23.
Preferably, include the following steps: S31 in the step S3: the coordinate data of the contour line point below divided by
The light velocity corrects the coordinate data after ratio is once corrected, and the light velocity correction ratio is the near infrared light in cornea
The ratio of spread speed and aerial spread speed；S32: the near infrared light is calculated described according to the law of refraction
Refraction angle in cornea；S33: according to after the primary correction coordinate data and the refraction angle obtain the institute after secondary correction
The coordinate data for stating contour line point below obtains the real image of the cornea.
Preferably, include the following steps: S41 in the step S4: choosing the half conduct of the real image of the cornea
Half room angle image carries out half room angle image after two points of processing obtain two points to half room angle image；S42: to described two points
Half room angle image afterwards does connected region processing, obtains maximum two connected regions, the center of the connected region is close to institute
The connected region of half room angle image after stating two points is the iris, another described connected region is the cornea.
Preferably, include the following steps: S51 in the step S5: being determined with the boundary point at the close room angle of the iris
Longitudinal axis；S52: the intersection point of the lower boundary of the longitudinal axis and the cornea is the scleral spur.
Preferably, include the following steps: that the contour line of the upper surface with the iris translates up in the step S5
The intersection point of the contour line of the lower surface of the cornea is the scleral spur.
Preferably, the anterior ocular segment cornea image acquired in the step S1 is 20-30.
The invention has the benefit that providing a kind of method of determining scleral spur, at the moment by near infrared light acquisition
Cornea image is saved, and image is further processed, the position of scleral spur is determined according to the position of iris, can accomplish anterior ocular segment eye
The integrated measuring of deutomerite saves cost.
Detailed description of the invention
Fig. 1 is a kind of method schematic diagram of determining scleral spur in the embodiment of the present invention.
Fig. 2 is the method schematic diagram that the contour line of upper surface of cornea is determined in the embodiment of the present invention.
Fig. 3 is the method schematic diagram that the real image of cornea is obtained in the embodiment of the present invention.
Fig. 4 is the method schematic diagram that iris and cornea are determined in the embodiment of the present invention.
Fig. 5 is the method schematic diagram for determining the position of scleral spur in the embodiment of the present invention according to the position of the iris.
Fig. 6 is the anterior ocular segment cornea image schematic diagram of high definition in the embodiment of the present invention.
Fig. 7 is the schematic diagram of the true picture of cornea in the embodiment of the present invention.
Fig. 8 is the schematic diagram at half room angle in the embodiment of the present invention.
Fig. 9 is the image schematic diagram in the embodiment of the present invention after two points.
Figure 10 is the schematic diagram for making connected region processing in the embodiment of the present invention to the image after two points.
Figure 11 is the schematic diagram of chamber-angle structure in the embodiment of the present invention.
Figure 12 be in the embodiment of the present invention near infrared light anterior corneal surface reflect schematic diagram.
Wherein, 1- cornea, 2- scleral spur, 3- iris, 4- incidence angle, the refraction angle 5-, 6- is divided by correcting after light velocity ratio
Position, 7- initial point position, the position after 8- refractive correction, 9- refracted light, 10- incident ray, the cornea table of 11- fitting
Face, the boundary point of 12- iris, the boundary point of 13- iris.
Specific embodiment
The present invention is described in detail by specific embodiment with reference to the accompanying drawing, for a better understanding of this hair
It is bright, but following embodiments are not intended to limit the scope of the invention.In addition, it is necessary to illustrate, diagram provided in following embodiments
The basic conception that only the invention is illustrated in a schematic way, in attached drawing only display with related component in the present invention rather than according to reality
Component count, shape when implementation and size are drawn, when actual implementation each component shape, quantity and ratio can for it is a kind of with
The change of meaning, and its assembly layout form may also be increasingly complex.
Embodiment 1
As shown in Figure 1, a kind of method of determining scleral spur, includes the following steps:
S1: anterior ocular segment cornea image is acquired using near infrared light；
S2: the contour line of the upper surface of cornea is determined by the anterior ocular segment cornea image；
S3: refractive correction is carried out to the contour line of upper surface described in anterior ocular segment cornea image point below and obtains angle
The real image of film；
S4: iris and cornea are determined in the real image of the cornea；
S5: the position of scleral spur is determined according to the position of the iris.
In a kind of specific embodiment of the invention, the wavelength of the near infrared light is 790nm-890nm；In step S1
The anterior ocular segment cornea image of acquisition is 20-30；The gray value chosen in step S2 is 20-30.
As shown in Fig. 2, including the following steps: in the step S2 in a kind of specific embodiment of the invention
S21: it chooses gray value threshold value and two points of processing is carried out to the anterior ocular segment cornea image, obtain bipartite graph picture；
S22: connected region processing is carried out to the bipartite graph picture, determines the partial contour line of the upper surface of cornea；
S23: being fitted the point of the partial contour line, obtains the integrity profile line of the upper surface of cornea.
It is understood that including: to carry out 2 to the point of the partial contour line in a kind of specific embodiment, in S23
Secondary fitting obtains parabola；The gray value of selection is 20-30.
As shown in figure 3, including the following steps: in step S3 in a kind of specific embodiment
S31: the coordinate data of the contour line point below corrects the coordinate after ratio is once corrected divided by the light velocity
Data, the light velocity correction ratio are the ratios of spread speed and aerial spread speed of the near infrared light in cornea
Value；
S32: refraction angle of the near infrared light in the cornea is calculated according to the law of refraction；
S33: according to after the primary correction coordinate data and the refraction angle obtain the profile after secondary correction
The coordinate data of line point below obtains the real image of the cornea.
As shown in figure 4, including the following steps: in step S4 in a kind of specific embodiment
S41: the half of the real image of the cornea is chosen as half room angle image, two are carried out to half room angle image
Half room angle image after dividing processing to obtain two points；
S42: connected region processing is done to half room angle image after described two points, obtains maximum two connected regions, institute
The connected region for stating half room angle picture centre of the center of connected region after described two points is the iris, described in another
Connected region is the cornea.
As shown in figure 5, including the following steps: in step S5 in a kind of specific embodiment
S51: longitudinal axis is determined with the boundary point at the close room angle of the iris；
S52: the intersection point of the lower boundary of the longitudinal axis and the cornea is the scleral spur.
In another specific embodiment, include the following steps: in step S5 with the contour line of the upper surface of the iris
The intersection point for translating up the contour line of the lower surface of the cornea is the scleral spur.
Embodiment 2
The present embodiment illustrates the present processes using more specific step:
1. as figure is opened one's eyes prosthomere cornea image with the near infrared light of 790nm acquisition 20, to the anterior ocular segment cornea of acquisition
Image carries out alignment operation, and then superposition obtains the clear anterior ocular segment cornea image of a panel height.
In another specific embodiment of the present invention, before being opened one's eyes using the near infrared light acquisition 30 of 890nm
Save cornea image.
2. determining the contour line of the upper surface of cornea by the anterior ocular segment cornea image；
Comprising two and half room angles of left and right inside the room angle original image of anterior ocular segment OCT acquisition, since light is in air and cornea
The refractive index of interior tissue liquid is different, needs to carry out refractive correction to room angle to obtain close to true cornea image.Select gray value
The threshold value of 20-30 carries out two points to image, can find cornea by connected region, so that it is determined that the upper surface of left and right cornea
Partial contour line, then carrying out quadratic fit to a series of point of the partial contour line for the upper surface found can be obtained parabolic
Line, the parabola can be approximated to be the integrity profile line of the upper surface of cornea.
3. the contour line of upper surface point below carries out refractive correction and obtains the reality of cornea in pair anterior ocular segment cornea image
Image；
As shown in figure 12, since speed of the light inside air and cornea is different, the profile of the anterior corneal surface 11 of fitting
The coordinate data put below line is needed divided by light in the speed of cornea and the velocity ratio of air, specifically, incident ray 10 with
Incidence angle 4 enters cornea, obtains refracted light 9；The coordinate data of initial point position 7 is needed divided by light in the speed of cornea and sky
It is obtained after the velocity ratio of gas divided by the position 6 corrected after light velocity ratio.
Then refraction angle of the near infrared light in cornea is calculated according to law of refraction n1*sin (a1)=n2*sin (a2).
Wherein, n1 is the refractive index in air, and al is the angle of incidence angle 4, and n2 is the refractive index of cornea, and calculated a2 is refraction angle
5 angle, and then the position after refractive correction 8 is obtained to get the real image of cornea is arrived.
4. determining iris and cornea in the real image of the cornea；
As shown in figure 8, selecting the half of the real image of cornea as half room angle in the real image of cornea.Such as Fig. 9
It is shown, it selects gray value 20-30 to carry out two points of processing to image, connected region processing is then done respectively to left and right room angle.Connected region
Domain algorithm is labeled to connected region each in bianry image, so that the target in image is positioned and be counted.
As shown in Figure 10, in maximum 2 connected regions, Ban Fangjiao of the center of the connected region after two points
The connected region of picture centre is iris, another connected region is cornea.
5. determining the position of scleral spur according to the position of the iris.
As shown in figure 11, since light is vertical injection cornea 1, since the absorption of 1 pair of light of cornea on 2 both sides of scleral spur is not
The same, it is possible to the position of scleral spur 2 is determined according to the point on the most boundary of iris 3.Specifically, two boundaries of iris 3
Point is respectively the iris boundary point 12 close to room angle and the iris boundary point 13 close to pupil, close to the iris boundary point at room angle
12 determine the longitudinal axis 14 for being parallel to human eye's visual axis and optical axis, and longitudinal axis 14 and the intersection point of the lower boundary of cornea are sclera
Prominent 2.
In another embodiment, the wheel of the lower surface of the cornea is translated up with the contour line of the upper surface of iris
The intersection point of profile is scleral spur.
As is illustrated by figs. 11 and 12, a vertical line and iris are done with the position that scleral spur 2 is starting point 500um or 750um forward
Another point is given, 2 points of vertical range is taken.One iris spatial area of girder (trabecular-iris space area,
TISA), be a trapezoidal area, boundary definition is as follows: front border is AOD500 or AOD750；Back boundary is scleral spur and sclera
The vertical line of inner wall is to opposite side iris；Coboundary is corneoscleral junction inner sidewall；Lower boundary is iris surface, may further carry out disease
The diagnosing and treating of disease.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those skilled in the art to which the present invention belongs, it is not taking off
Under the premise of from present inventive concept, several equivalent substitute or obvious modifications can also be made, and performance or use is identical, all answered
When being considered as belonging to protection scope of the present invention.
Claims (10)
1. a kind of method of determining scleral spur, which comprises the steps of:
S1: anterior ocular segment cornea image is acquired using near infrared light；
S2: the contour line of the upper surface of cornea is determined by the anterior ocular segment cornea image；
S3: refractive correction is carried out to the contour line of upper surface described in anterior ocular segment cornea image point below and obtains the angle
The real image of film；
S4: iris and the cornea are determined in the real image of the cornea；
S5: the position of scleral spur is determined according to the position of the iris.
2. determining the method for sclera as described in claim 1, which is characterized in that the wavelength of the near infrared light is 790nm-
890nm。
3. determining the method for scleral spur as described in claim 1, which is characterized in that include the following steps: in the step S2
S21: it chooses gray value threshold value and two points of processing is carried out to the anterior ocular segment cornea image, obtain bipartite graph picture；
S22: connected region processing is carried out to the bipartite graph picture, determines the partial contour line of the upper surface of cornea；
S23: being fitted the point of the partial contour line, obtains the integrity profile line of the upper surface of cornea.
4. determining the method for scleral spur as claimed in claim 3, which is characterized in that the gray value chosen in the step S21
For 20-30.
5. the method for the determination scleral spur as described in right wants 3, which is characterized in that include: to the partial contour in step S23
The point of line carries out 2 fittings and obtains parabola.
6. determining the method for scleral spur as described in claim 1, which is characterized in that include the following steps: in the step S3
S31: the coordinate data of the contour line point below corrects the coordinate data after ratio is once corrected divided by the light velocity,
The light velocity correction ratio is the ratio of the near infrared light spread speed in cornea and aerial spread speed；
S32: refraction angle of the near infrared light in the cornea is calculated according to the law of refraction；
S33: according to after the primary correction coordinate data and the refraction angle obtain the contour line after secondary correction with
Under point coordinate data, obtain the real image of the cornea.
7. determining the method for scleral spur as described in claim 1, which is characterized in that include the following steps: in the step S4
S41: the half of the real image of the cornea is chosen as half room angle image, two are carried out to half room angle image and is existed respectively
Manage half room angle image after obtaining two points；
S42: connected region processing is done to half room angle image after described two points, obtains maximum two connected regions, the company
The connected region center of half room angle image of the center in logical region after described two points is the iris, another described company
Logical region is the cornea.
8. determining the method for scleral spur as described in claim 1, which is characterized in that include the following steps: in the step S5
S51: longitudinal axis is determined with the boundary point at the close room angle of the iris；
S52: the intersection point of the lower boundary of the longitudinal axis and the cornea is the scleral spur.
9. determining the method for scleral spur as described in claim 1, which is characterized in that include the following steps: in the step S5
The intersection point that the contour line of the lower surface of the cornea is translated up with the contour line of the upper surface of the iris is the Gong
Film is prominent.
10. the method for the determination scleral spur as described in claim 1-9 is any, which is characterized in that acquired in the step S1
The anterior ocular segment cornea image is 20-30.
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| JPH11113885A (en) * | 1997-10-08 | 1999-04-27 | Oki Electric Ind Co Ltd | Individual identification device and method thereof |
| US20040068192A1 (en) * | 2002-07-12 | 2004-04-08 | Volker Westphal | Method and system for quantitative image correction for optical coherence tomography |
| US20070191863A1 (en) * | 2006-01-17 | 2007-08-16 | De Juan Eugene Jr | Glaucoma Treatment Device |
| CN102136135A (en) * | 2011-03-16 | 2011-07-27 | 清华大学 | Method for extracting inner outline of cornea from optical coherence tomography image of anterior segment of eye and method for extracting inner outline of anterior chamber from optical coherence tomography image of anterior segment of eye |
| US8967810B1 (en) * | 2013-04-30 | 2015-03-03 | Thomas C. Prager | Methodology to identify the scleral spur |
| CN105608314A (en) * | 2015-12-17 | 2016-05-25 | 深圳市斯尔顿科技有限公司 | Corneal diopter calculation method and system |
| CN108652583A (en) * | 2018-02-11 | 2018-10-16 | 温州眼视光发展有限公司 | Detect corneal thickness and the device and method of curvature |
-
2019
- 2019-03-18 CN CN201910204642.6A patent/CN110063710B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11113885A (en) * | 1997-10-08 | 1999-04-27 | Oki Electric Ind Co Ltd | Individual identification device and method thereof |
| US20040068192A1 (en) * | 2002-07-12 | 2004-04-08 | Volker Westphal | Method and system for quantitative image correction for optical coherence tomography |
| US20070191863A1 (en) * | 2006-01-17 | 2007-08-16 | De Juan Eugene Jr | Glaucoma Treatment Device |
| CN102136135A (en) * | 2011-03-16 | 2011-07-27 | 清华大学 | Method for extracting inner outline of cornea from optical coherence tomography image of anterior segment of eye and method for extracting inner outline of anterior chamber from optical coherence tomography image of anterior segment of eye |
| US8967810B1 (en) * | 2013-04-30 | 2015-03-03 | Thomas C. Prager | Methodology to identify the scleral spur |
| CN105608314A (en) * | 2015-12-17 | 2016-05-25 | 深圳市斯尔顿科技有限公司 | Corneal diopter calculation method and system |
| CN108652583A (en) * | 2018-02-11 | 2018-10-16 | 温州眼视光发展有限公司 | Detect corneal thickness and the device and method of curvature |
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