CN110057888A - Impedance chip detecting system for biological detection - Google Patents
Impedance chip detecting system for biological detection Download PDFInfo
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- CN110057888A CN110057888A CN201810054312.9A CN201810054312A CN110057888A CN 110057888 A CN110057888 A CN 110057888A CN 201810054312 A CN201810054312 A CN 201810054312A CN 110057888 A CN110057888 A CN 110057888A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
- G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
- G01N27/126—Composition of the body, e.g. the composition of its sensitive layer comprising organic polymers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
- G01N27/125—Composition of the body, e.g. the composition of its sensitive layer
- G01N27/127—Composition of the body, e.g. the composition of its sensitive layer comprising nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/12—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluid; of a solid body in dependence upon reaction with a fluid, for detecting components in the fluid
- G01N27/128—Microapparatus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/307—Disposable laminated or multilayered electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Electrochemistry (AREA)
- Hematology (AREA)
- Nanotechnology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Abstract
The invention discloses a kind of impedance chip detecting systems for biological detection, it includes sensor and portable detectors, wherein, sensor includes absorbed layer, sensing layer and transfer layer, detector includes detection slot, one for carrying out the control module of impedance measurement and calculating and the display module of the testing result for showing a specimen for a specimen, whereby, after so that sensor is inserted in detection slot, impedance measurement is carried out for a specimen for sensor and is calculated, and shows testing result in detector.
Description
Technical field
The present invention relates to a kind of impedance chip detecting systems for biological detection, espespecially can sense a specimen by sensor
Afterwards, the system for completing biological detection using the detector for having portable circuit module.
Background technique
According to showing in Total Biosensor Market market analysis in 2016 investigation, bio-detector is used for
Home care will be following development pattern of raw doctor's detection, and estimates and there will be over 65% or more and focus on house using group
Front yard diagnosis enables sufferer to reach detection function by easy and low cost equipment at home.
Since paper has the characteristics that low cost, high productivity and versatility, and utilize sensor energy made by paper
Suitable for more elastic, portable, it is disposable and can ease of Use detection, the portability assigned, convenience and immediately
Property makes paper mold sensor be increasingly becoming the development trend in biosensor future.Therefore, Chinese patent announces No. 103041876
A kind of " application in the preparation of three-dimensional microflow control paper chip and at the scene Electrochemical Detection " is disclosed, on three filter paper batches
It measures and prints hydrophobic wax pattern, after was moulding fusion, in batch wire mark array working electrode, reference electrode on filter paper and to electricity
Pole, and in filter paper without bulk print horseradish peroxidase and oxidizing ferment on working electrode face, then, lead to after cutting paper chip
Double coated film bonding filter paper is crossed to constitute the micro-fluidic paper chip folder of three Dimensional Electrochemical.However, above-mentioned paper mold sensor must link
Electrochemical workstation reads detection data, to know kinetic current degree of strength, and then completes biological material analysis detection, because
This can not promote the efficiency of subsequent measurement numerical analysis, to still have though the sensor can promote the convenience of detection operation
It is to be modified.
Summary of the invention
Inventor still has in view of paper mold sensor in the prior art and can not promote the subsequent measurement number of sensor
The problem of being worth analysis efficiency.Therefore, the purpose of the present invention is to provide one kind for reading detection data and having portable circuit
The system of detector.
In order to achieve the above object, the present invention provides a kind of impedance chip detecting system for biological detection, which includes:
One sensor is applied to biological detection, and mono- absorbed layer of Bao Han ︰, is dust-free paper, to absorb an extra specimen；One sensing layer, knot
Together in the absorbed layer, and include a substrate with electrode pattern, has antibody nanoparticle in the electrode pattern surface modification, and
Adhesive is combined with above the substrate, and the adhesive is solidified to form hydrophobic region；And a transfer layer, with hydrophilic cementing
Together in the sensing layer, and include a filter paper, adhesive is combined with above the filter paper, and the adhesive is solidified to form hydrophobic region
Domain and one for transport a specimen runner；And a detector, the detector are portable impedance chip detector, and for detecting
The specimen that the sensor is transported, and mono- shell of Bao Han ︰, the detection slot planted with one for the sensor；One control module is used
It carries out impedance measurement in for the specimen and calculates, and include the gain optimization module and use to the multiple test points of Auto-Sensing
To select the impedance demodulation module of optimal detection point, and it is confirmed whether after completing impedance computation beyond error range；And one
Display module is incorporated into the shell and electrical communication in control module, for showing the testing result or warning alert of a specimen.
Based on above-mentioned, enable sensor by transfer layer and sensing layer by detecting electrode and reference electrode simultaneous reactions, then
Sensor is inserted in the detection slot of detector, to carry out impedance measurement for the specimen on sensor and calculate, and directly in
Detector shows the testing result or warning alert of a specimen, and then promotes the convenience and efficiency of raw doctor's detection.
Detailed description of the invention
Fig. 1 is architecture diagram of the invention.
Fig. 2 is the stereogram exploded view of inventive sensor.
Fig. 3 A~Fig. 3 B is the production flow diagram of inventive sensor.
Fig. 4 is the stereogram exploded view of detector of the present invention.
Fig. 5 is the electrical block diagram of detector of the present invention.
Fig. 6~Fig. 7 is the schematic diagram that the present invention carries out biological detection.
Fig. 8 is the flow chart that the present invention carries out biological detection.
Fig. 9 is the schematic diagram of the testing result of inventive sensor experiment.
Figure 10 is detector of the present invention figure compared with commercially available measurement board testing result.
Description of symbols: 1- system；2- sensor；21- absorbed layer；22- sensing layer；221- substrate；222- electrode figure
Case；223- adhesive；224- antibody nanoparticle；23- transfer layer；231- filter paper；232- adhesive；233- runner；24- filtering
Layer；25- shell；251- window；3- detector；31- shell；311- detection slot；312- slot；32- control module；321- gain
Optimization module；322- impedance demodulation module；33- display module；34- radio transmitting device；35- charging module；36- temperature-sensitive mould
Block；4- cloud system；A 5- specimen；S21~S25- sensor production step；S30~S39- detector test step.
Specific embodiment
Firstly, refering to Figure 1, system 1 of the invention includes a sensor 2, a detector 3 and a cloud system
4, wherein sensor 2 is applied to biological detection, and includes 23 (cooperation ginseng of an absorbed layer 21, a sensing layer 22 and a transfer layer
Read Fig. 2), which is dust-free paper, to absorb an extra specimen；The sensing layer 22 is incorporated into absorbed layer 21, and includes one
Substrate 221 with electrode pattern 222 has antibody nanoparticle 224 (not show in figure positioned at 222 surface modification of electrode pattern
Show), and adhesive 223 is combined with above substrate 221, and adhesive 223 is solidified to form hydrophobic region, in it is of the invention compared with
In good embodiment, substrate 221 can be paper base plate, PET film or glass substrate；The transfer layer 23 is incorporated into sensing layer with hydrophilic gel
22, and include a filter paper 231, adhesive 232 is combined with above filter paper 231, and adhesive 232 is solidified to form hydrophobic region
And one for transport a specimen runner 233, in presently preferred embodiments of the present invention, runner 233 include to drive a specimen flow
Micropump.
It is below that embodiment Jin row Shuos the production of Ming ︰ paper base plate sensor 2 upper (cooperation is refering to Fig. 3 A with paper base plate sensor 2
~Fig. 3 B), (step S21) selects the filter paper for having appropriate hole size as printing paper base plate 221, recycles screen printing technology
Or conducting solution is printed in paper base plate 221 to form the electrode pattern 222 of tool specific shape by intaglio plate die rolls, preferably,
The conducting solution is precious metal solution, specifically for fulmargin.And its electrode pattern 222 is finger-fork type electrode, and with left and right two
Side is arranged in pectination.Then, (step S22) sprays appropriate UV glue stick 223 in paper base plate 221, and wears adhesive 223
Saturating paper depth, then make colloid solidification that can cover specific region by irradiating UV lamp and form hydrophobic region in paper base plate 221；
And appropriate UV glue stick 232 is sprayed in another filter paper 231, and equally solidify colloid by UV lamp, there is filter paper 231
Hydrophobic region, and the part for making filter paper 231 not spray colloid forms a runner 233, to constitute transfer layer 23.The position (step S23)
In 222 surface modification of electrode pattern in combination with the antibody nanoparticle 224 of molecules detected to constitute a sensing layer 22.(step
S24 sensing layer 22 and transfer layer 23 sequentially) are fitted in by an absorbed layer 21 with hydrophilic gel, to absorb extra inspection by absorbed layer 21
Body；And constitute a paper base plate sensor 2 (step S25).And the sensor 2 can be packaged in the shell 25 of a tool window 251, and
A filter layer 24 (Fig. 2 please be look back) is set between shell 25 and sensor 2.
Secondly, the detector 3 is portable impedance chip detector 3, and for examining please refer to shown in Fig. 4~Fig. 5
The specimen that sensor 2 is transported is surveyed, and includes a shell 31, a control module 32, a display module 33, a radio transmitting device
34, a charging module 35 and a temperature-sensitive module 36, wherein there is shell 31 detection slot 311 planted for sensor 2 (to ask
Look back Fig. 1)；The control module 32 includes to certainly for carrying out impedance measurement for the specimen 5 on sensor 2 and calculating
The gain optimization module 321 of the dynamic multiple test points of detecting and the impedance demodulation module 322 to select optimal detection point, and in complete
At being confirmed whether after impedance computation beyond error range, in one embodiment of the invention, 32 circuit of control module is that scene can
Programmable gate array (Field-Programmable Gate Array, FPGA) chip；The display module 33 includes organic light emission
Diode (Organic Light-Emitting Diode, OLED), and shell 31 and electrical communication are incorporated into control module
32, for showing the testing result or warning alert of a specimen 5；The radio transmitting device 34 is bluetooth (Blue tooth) device,
And the testing result of sensor 2 is transmitted to cloud system 4；The charging module 35 forms one for connection outside in shell 31
The USB slot 312 of electric power, to pass through electric power needed for slot 312 provides or store detector 3；The temperature-sensitive module 36 is to sense
Whether 5 temperature of a specimen is located at setting range, and is heated when Yu Weida setting range.
Then, it please refers to shown in Fig. 6~Fig. 7, since the prevalence rate of chronic kidney disease in recent years has year by year in countries in the world
Soaring trend, and do not know itself to suffer from this disease and delay treatment in this state-owned about ninety percent or more patient, therefore, of the invention grinds
Study carefully experiment and the design of system 1 is applied to protein content detection in urine.It is visited using 1 micron of size of polyaniline biology micron
Needle (PANI MPs), by aluminium oxide (Al in the way of redox2O3) particle surface coating conducting polyaniline (PANDB) material
Material to form probe with silane-functional base modification particle surface so that antibody is bonded and serve as bio-identification component, no bond antibody
Probe then as control, and respectively will have bond antibody and without bond antibody probe modification in detection zone and reference area table
Face.
In this experiment, it first will test the booting of instrument 3 and carry out after warming-up and self-correction (cooperation is refering to Fig. 8), by paper base plate
Sensor 2 is inserted in the detection slot 311 of detector 3, and in the window of sensor 2 251 drips upper deionized water to carry out chip
Initial value measures (Z0), then instills paper base plate sensor 2 by a specimen 5 of protein solution, buffers a specimen 5 via filter layer 24
Afterwards, by the micropump of runner 233 to reach best 389 μ L/min of flow rate, back pressure 6cm- under input voltage 5V, frequency 40Hz
H2O, and then drive a specimen 5 in biochip surface flow guide to detection zone and reference area, (step S30) passes through biological antibody
Immunoassay is generated between protein to react after five minutes, (step S31) carries out 5 temperature sensing of a specimen by temperature-sensitive module 36,
In this present embodiment, preferred temperature setting range be 26 DEG C~30 DEG C, (step S32) if 5 temperature of a specimen does not reach setting range,
The temperature control of temperature-sensitive module 36 and motor drive to be heated, (step S33) and when checking again for temperature with reacting after heating
Between, then, (step S34) carries out impedance measurement and (step S35) computing impedance after rinsing the deionized water dripped, by institute
In the protein solution of reaction, antigen can be produced from a group property with antibody and mutually graft phenomenon, therefore its impedance rate of change can be calculated to obtain
Know 5 reaction result of a specimen, (step S36) when the result calculated is without departing from setting range, (step S37) is then recorded and will inspection
It surveys as the result is shown in detector 3, and when the result calculated exceeds setting range, (step S38) is then confirmed whether to fall in measurement
Range, if not falling within measurement range, (step S39) passes through the relay array of the gain optimization module 321 of control module 32
Handoff gain resistance, and by impedance demodulation module 322 select optimal detection point after return, (return step S34) with again into
Row impedance measurement.
The range that detection protein corresponds to disease at present can be divided into Wu Qi ︰
The chronic kidney disease first phase (urine exception but normal renal function) Albumin albumin content < 30mg/24hr
The chronic kidney disease second phase (slight chronic kidney disease) Albumin albumin content < 30mg/24hr
The chronic kidney disease third phase 30~299mg/24hr of (moderate chronic kidney trouble) Albumin albumin content
The chronic kidney disease fourth phase (severe chronic kidney trouble) Albumin albumin content > 300mg/24hr
The chronic kidney disease fifth phase (end stage renal disease) Albumin albumin content > 300mg/24hr
Through this experimental result, please refer to Fig. 9, sensor 2 detects about 14 times of change rate, it is dense to have reached albumin
It spends lowest detection limit 0.3mg/ml (the following table 1 please be join), it is identical as the presently commercially available test paper limit, therefore calculate sensor of the invention
2 can reach the discrimination of fourth phase chronic kidney disease.
Table 1
In addition, detector 3 of the invention is with comparison range 1K~1M (Ω), measurement frequency 10KHz and commercially available impedance analysis
Instrument (LCR Meter) is compared (please refer to Figure 10), and comparison result is shown, its error amount of detector 3 of the invention
It is controlled in 1~2% range, therefore with commercially available impedance analyzer numerical value and no significant difference, so as to for replacing volume huge
Big impedance analyzer.
Therefore, following Gong Xiao ︰ obviously can be reached using system of the invention
1, sensor of the invention, which is able to cooperate biological immune reaction mechanism, can be applied to a variety of detection fields, and have
The advantages that multi-functional, quick, highly sensitive and low cost, so as to pacify for clinical and chemical analysis and disease detection, food
Other detection fields such as problem, pesticide residue, influenza virus or drugs screening.
2, detector of the invention is small in size, tool is portable, therefore can replace bulky impedance analyzer, and can supply
Sufferer passes through easy and low cost equipment at home and reaches detection function, promotes the convenience of home care.
3, after detector of the invention can arrange in pairs or groups sensor progress specimen detection, it will test result and pass through radio transmitting device
It is uploaded to cloud system, the reference frame for caregiver or medical institutions as tracking and diagnosis and treatment.
The foregoing is merely presently preferred embodiments of the present invention, the practical range being not intended to limit the invention, it is all without departing from
Variation and modification carried out by the technology of the present invention spirit, are all that protection scope of the present invention is covered.
Claims (10)
1. a kind of impedance chip detecting system for biological detection, characterized by comprising:
One sensor is applied to biological detection, and Bao Han ︰
One absorbed layer is dust-free paper, to absorb an extra specimen；
One sensing layer is incorporated into the absorbed layer, and includes a substrate with electrode pattern, has in the electrode pattern surface modification
Antibody nanoparticle, and adhesive is combined with above the substrate, and the adhesive is solidified to form hydrophobic region；And
One transfer layer is incorporated into the sensing layer with hydrophilic gel, and includes a filter paper, and adhesive is combined with above the filter paper, and
The adhesive be solidified to form hydrophobic region and one for transport a specimen runner；And
One detector, the detector are portable impedance chip detector, and for detecting the specimen that the sensor is transported, and
Bao Han ︰
One shell, the detection slot planted with one for the sensor；
One control module for carrying out impedance measurement for the specimen and calculating, and includes to the multiple test points of Auto-Sensing
Gain optimization module and the impedance demodulation module to select optimal detection point, and be confirmed whether to surpass after completing impedance computation
Error range out；And
One display module, is incorporated into the shell and electrical communication in the control module, for show the specimen testing result or
Warning alert.
2. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the base of the sensor
Plate is paper base plate, PET film or glass substrate.
3. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the electrode of the substrate
Pattern is finger-fork type electrode.
4. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the runner further includes
To the micropump for driving a specimen to flow.
5. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the detector more wraps
Containing a radio transmitting device, the testing result is transmitted to cloud system.
6. being used for the impedance chip detecting system of biological detection as claimed in claim 5, which is characterized in that wireless transmission dress
It is set to blue-tooth device.
7. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the detector more wraps
Containing a charging module, and in shell formation one for the slot of connection external power, to provide or store the inspection by the slot
Electric power needed for surveying instrument.
8. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the control of the detector
Modular circuit processed is field programmable gate arrays chip.
9. being used for the impedance chip detecting system of biological detection as described in claim 1, which is characterized in that the detector more wraps
Containing temperature-sensitive module, which carries out to sense whether specimen temperature is located at setting range, and when Yu Weida setting range
It heats.
10. being used for the impedance chip detecting system of biological detection as claimed in claim 9, which is characterized in that the temperature-sensitive module
Temperature setting range be 26 DEG C~30 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810054312.9A CN110057888A (en) | 2018-01-19 | 2018-01-19 | Impedance chip detecting system for biological detection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810054312.9A CN110057888A (en) | 2018-01-19 | 2018-01-19 | Impedance chip detecting system for biological detection |
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| CN110057888A true CN110057888A (en) | 2019-07-26 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669656A (en) * | 2019-09-30 | 2020-01-10 | 浙江大学 | Disposable experimental device and method for rapid and simple detection of integrated gene by impedance method |
| TWI739318B (en) * | 2020-02-24 | 2021-09-11 | 國立陽明交通大學 | An impedance-type chip for measuring instantaneous sweat pressure, a micro-control system for sweat pressure measurement, and a measuring method of instantaneous sweat pressure |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102735722A (en) * | 2011-04-01 | 2012-10-17 | 泰博科技股份有限公司 | Biosensor strip and manufacturing method thereof |
-
2018
- 2018-01-19 CN CN201810054312.9A patent/CN110057888A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102735722A (en) * | 2011-04-01 | 2012-10-17 | 泰博科技股份有限公司 | Biosensor strip and manufacturing method thereof |
Non-Patent Citations (4)
| Title |
|---|
| CHENG-HSIN CHUANG等: "Miniaturization of immunoassay by using a novel module-level immunosensor with polyaniline-modified nanoprobes that incorporate impedance sensing and paper-based sampling", 《MICROFLUID NANOFLUID》 * |
| CHENG-HSIN CHUANG等: "PAPER BASED IMPEDIMETRIC IMMUNOASSAY FOR LABEL FREE DETECTION OF URINARY ALBUMIN", 《19TH INTERNATIONAL CONFERENCE ON MINIATURIZEDSYSTEMS FOR CHEMISTRY AND LIFE SCIENCES》 * |
| KENTARO YAMADA等: "Paper-Based Inkjet-Printed Microfluidic Analytical Devices", 《ANGEW. CHEM. INT. ED》 * |
| XUHAI CHEN等: "FPGA-based Floating-Point Data Acquisition System with Automatic-Gain-Control and Peak-Detection for Multi-channel Electrochemical Measurement", 《2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110669656A (en) * | 2019-09-30 | 2020-01-10 | 浙江大学 | Disposable experimental device and method for rapid and simple detection of integrated gene by impedance method |
| CN110669656B (en) * | 2019-09-30 | 2021-07-06 | 浙江大学 | Disposable experimental device and method for rapid and simple detection of integrated gene by impedance method |
| TWI739318B (en) * | 2020-02-24 | 2021-09-11 | 國立陽明交通大學 | An impedance-type chip for measuring instantaneous sweat pressure, a micro-control system for sweat pressure measurement, and a measuring method of instantaneous sweat pressure |
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