CN110051718A - A kind of bone hyperplasia rehabilitation medicinal liquor - Google Patents
A kind of bone hyperplasia rehabilitation medicinal liquor Download PDFInfo
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- CN110051718A CN110051718A CN201910467825.7A CN201910467825A CN110051718A CN 110051718 A CN110051718 A CN 110051718A CN 201910467825 A CN201910467825 A CN 201910467825A CN 110051718 A CN110051718 A CN 110051718A
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- safflower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/342—Adenophora
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a kind of bone hyperplasia rehabilitation medicinal liquors, liquid medicine is specifically made of following raw material: safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, pure grain wine, contains the raw material of following quality: 18-21 grams of safflower, 17-22 grams of Cortex Eucommiae, 19-21 grams of Radix Angelicae Sinensis, 18-22 grams of the root of straight ladybell in liquid medicine in every kilogram of pure grain wine.The present invention is made of pure Chinese medicine, without any side effects, and treatment method is simple, and non-relapse after healing is at low cost, and treatment cycle is short.
Description
Technical field
The present invention relates to a kind of liquid medicine, specifically a kind of bone hyperplasia rehabilitation medicinal liquor.
Background technique
Hyperostosis is mainly in above middle age.It is generally acknowledged that due to having a delicate constitution after the middle age and retrogression；For a long time
It stands or walks and be held in certain posture for a long time, due to the drawing of muscle or avulsion, bleeding, organization of hematoma forms thorn-like
Or the osteoproliferation of lip sample；Spur to soft tissue generate it is mechanical stimulation and wound after soft tissue injury, bleeding, swelling and
It causes.
Osteoproliferation is a kind of normal deterioration phenomenon of human senility, to a dating everyone activity it is more and
Can all there be different degrees of osteoproliferation in biggish joint such as cervical vertebra, knee joint, lumbar vertebrae etc. of bearing a heavy burden, if the spur of hyperplasia stimulates
Hyperosteogeny is just when having arrived local organization or nerve generation symptom.Common sympton has following three kinds: cervical vertebra increases
Life, lumbar vertebrae hyperosteogeny, articulatio genus hyperosteogeny.Therapeutic scheme common at present has following three kinds.
Western medical treatment: doctor trained in Western medicine there is no effective therapeutic agent to this disease at present, frequently with anti symptom treatment, can take when such as pain
The medicine of some antipyretic-antalgics；B family vitamin class drug can be selected in numb person；Arthroncus has hydrops, and person can give part extraction product
The therapies such as liquid or partial closure.But it facts have proved that these treatment methods are undesirable, only treat the symptoms without effecting a permanent cure, the state of an illness is easily multiple
Hair.Western medical treatment endo-medicine is absorbed by stomach, digestion, is decomposed, and finally by blood circulation, can just be inputted drug and be given
Part, whole process need to get to lesions position by barrier layer by layer, and right drug effect has remained little, therefore effect is extremely slow
It is slow and inefficient, and clinical application these methods can only relieve pain symptom, functional rehabilitation can not reverse, and bone repair is even more
It does not know where to begin, and oral medicine is very big to liver, kidney, gastrointestinal damage.
Massage and traction: it is suitable for neck, lumbar hyperosteogency.The effect of external force is leaned in massage with traction completely, is only played a game
Portion, which is treated, but to be ignored to integrally adjusting in human body, therefore, can only play temporary analgesic effect, and cannot be reached and be controlled
The purpose for the treatment of
Acupuncture: acupuncture clearing and activating the channels and collaterals and can have analgesic effect.Local oedema and inflammation can be eliminated, but to hyperostosis
For, acupuncture can only help out.
This disease is included in the scope of " heumatism " by motherland's medicine, it is believed that this disease occurs mostly due to insufficiency of vital energy and blood, caused by liver and kidney deficiency, wind
Cold-dampness heresy intrusion bone network falls servant's sudden strain of a muscle, hurt bone network, so that stagnation of QI-blood, operation is lost freely, not general rule pain.Osteoproliferation treating
Embody the advantage of Chinese medicine.Traditional Chinese Medicine experts DENG Tie-tao is said: " the advanced of Chinese medicine is exactly to lead in the case where not damaging any body
Disease can be cured by crossing conditioning." Western medicine is by animal experiment human body, and the classical prescription of Chinese medicine, proved recipe are then people
Ancestors verify the experience obtained in human body by centuries or more than one thousand years repeatedly, do not recur after curing, operation once failure
Correct chance all without.Practice repeatedly proves that Chinese medicine is also largely effective to chronic disease especially degenerative disorders
's.
Existing above-mentioned treatment method can not thoroughly solve the pain of sufferer, easy to recur, and treatment cost is high, treatment cycle
Long, therapeutic modality is complicated.
Summary of the invention
The purpose of the present invention is to provide a kind of bone hyperplasia rehabilitation medicinal liquors, to solve mentioned above in the background art ask
Topic.
To achieve the above object, the invention provides the following technical scheme:
A kind of bone hyperplasia rehabilitation medicinal liquor, the liquid medicine are specifically made of following raw material: safflower, Cortex Eucommiae, Radix Angelicae Sinensis, sand
Ginseng, pure grain wine.
As a further solution of the present invention, contain the raw material of following quality in the liquid medicine in every kilogram of pure grain wine:
18-21 grams of safflower, 17-22 grams of Cortex Eucommiae, 19-21 grams of Radix Angelicae Sinensis, 18-22 grams of the root of straight ladybell.
As further scheme of the invention, contain the original of following quality in the liquid medicine in every kilogram of pure grain wine
Material: 20 grams of safflower, 20 grams of Cortex Eucommiae, 20 grams of Radix Angelicae Sinensis, 20 grams of the root of straight ladybell.
In addition, the present invention also provides a kind of configuration method using above-mentioned raw materials preparation bone hyperplasia rehabilitation medicinal liquor, tool
Steps are as follows for body:
(1) raw material is chosen
The bulk pharmaceutical chemicals of safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell are chosen, remove impurity, while preparing one kilogram of pure grain wine, it is spare；
(2) liquid medicine is brewed
One kilogram of pure grain wine in step (1) is poured into glassware, then according to the matter of one kilogram of pure grain wine
Amount proportion weighs the safflower after removal impurity, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, then the Chinese medicine after weighing is put into it is brewed in glassware,
Brew time is 13-15 days, so that it may obtain required liquid medicine.
As a further solution of the present invention, the specific dosage of liquid medicine obtained in the step (2) is as follows: being divided into four treatments
Journey uses, each course for the treatment of 8 days, twice daily, 13 milliliters every time.
As a further solution of the present invention, the Time of Administration of the liquid medicine is taken for daily half an hour after morning and evening dinner, and
After taking for the first time, sweat need to be sealed into spur hyperplasia position with the modes such as hot towel or lid quilt, volume of perspiration should not be too large, each taking
It should rest after medicine at least half an hour, condition permits to be advisable for one hour；Heavy physical labour is not engaged in during medication, it can be extensive after healing
Multiple manual labor.
Compared with prior art, the beneficial effects of the present invention are:
The present invention is made of pure Chinese medicine, without any side effects, and treatment method is simple, and non-relapse after healing is at low cost,
Treatment cycle is short.
Specific embodiment
Technical solution of the present invention is described in more detail With reference to embodiment.
Embodiment 1
A kind of bone hyperplasia rehabilitation medicinal liquor, the liquid medicine are specifically made of following raw material: safflower, Cortex Eucommiae, Radix Angelicae Sinensis, sand
Ginseng, pure grain wine, and contain the raw material of following quality: 18 grams of safflower, 17 grams of Cortex Eucommiae, Radix Angelicae Sinensis in liquid medicine in every kilogram of pure grain wine
19 grams, 18 grams of the root of straight ladybell.
The present invention also provides a kind of configuration method using above-mentioned raw materials preparation bone hyperplasia rehabilitation medicinal liquor, specific steps
It is as follows:
(1) raw material is chosen
The bulk pharmaceutical chemicals of safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell are chosen, remove impurity, while preparing one kilogram of pure grain wine, it is spare；
(2) liquid medicine is brewed
One kilogram of pure grain wine in step (1) is poured into glassware, then according to the matter of one kilogram of pure grain wine
Amount proportion weighs the safflower after removal impurity, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, then the Chinese medicine after weighing is put into it is brewed in glassware,
Required liquid medicine is obtained after brewed 13 days.
Embodiment 2
A kind of bone hyperplasia rehabilitation medicinal liquor, the liquid medicine are specifically made of following raw material: safflower, Cortex Eucommiae, Radix Angelicae Sinensis, sand
Ginseng, pure grain wine, and contain the raw material of following quality: 20 grams of safflower, 20 grams of Cortex Eucommiae, Radix Angelicae Sinensis in liquid medicine in every kilogram of pure grain wine
20 grams, 20 grams of the root of straight ladybell.
The present invention also provides a kind of configuration method using above-mentioned raw materials preparation bone hyperplasia rehabilitation medicinal liquor, specific steps
It is as follows:
(1) raw material is chosen
The bulk pharmaceutical chemicals of safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell are chosen, remove impurity, while preparing one kilogram of pure grain wine, it is spare；
(2) liquid medicine is brewed
One kilogram of pure grain wine in step (1) is poured into glassware, then according to the matter of one kilogram of pure grain wine
Amount proportion weighs the safflower after removal impurity, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, then the Chinese medicine after weighing is put into it is brewed in glassware,
Required liquid medicine is obtained after brewed 14 days.
Embodiment 3
A kind of bone hyperplasia rehabilitation medicinal liquor, the liquid medicine are specifically made of following raw material: safflower, Cortex Eucommiae, Radix Angelicae Sinensis, sand
Ginseng, pure grain wine, and contain the raw material of following quality: 21 grams of safflower, 22 grams of Cortex Eucommiae, Radix Angelicae Sinensis in liquid medicine in every kilogram of pure grain wine
21 grams, 22 grams of the root of straight ladybell.
The present invention also provides a kind of configuration method using above-mentioned raw materials preparation bone hyperplasia rehabilitation medicinal liquor, specific steps
It is as follows:
(1) raw material is chosen
The bulk pharmaceutical chemicals of safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell are chosen, remove impurity, while preparing one kilogram of pure grain wine, it is spare；
(2) liquid medicine is brewed
One kilogram of pure grain wine in step (1) is poured into glassware, then according to the matter of one kilogram of pure grain wine
Amount proportion weighs the safflower after removal impurity, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, then the Chinese medicine after weighing is put into it is brewed in glassware,
Required liquid medicine is obtained after brewed 15 days.
The specific dosage of Chinese medicinal liquor of the present invention is as follows: it is divided into four courses for the treatment of and uses, each course for the treatment of 8 days, twice daily, every time
13 milliliters.
Meanwhile after the Time of Administration of liquid medicine is takes, and first time takes after morning and evening dinner daily half an hour, hot towel need to be used
Or sweat is sealed in spur hyperplasia position by the modes such as lid quilt, and volume of perspiration should not be too large, it should rest at least half an hour after medication every time, item
Part permits to be advisable for one hour；Heavy physical labour is not engaged in during medication, can regain one's strength labour after healing.
In addition, the present invention also provides the specific implementation cases for using the rehabilitation medicinal liquor.
Clinical bone hyperplasia patient 20 is chosen, it is made to take therapy rehabilitation liquid medicine of the present invention, duration of medication is refused to obey
With other drugs, and it is not engaged in heavy physical labour, instructions of taking are as follows: the time is that half an hour takes after morning and evening dinner daily, each taking
Rest half an hour a to hour after medicine；It is divided into four courses for the treatment of to use, each course for the treatment of 8 days, twice daily, 13 milliliters every time.
Duration of medication, each course for the treatment of check patient, and four rehabilitation situations treated into rear record every patient are controlled
Therapeutic effect is divided into effective, invalid and cures three kinds:
Effectively-symptom mitigates, and has clear improvement, pain relief；
Five significant change of in vain-patient symptom itself；
Healing-hyperplasia position disappears, can normal activity, no influence.
The therapeutic effect after checking are as follows: cure 18 people of number, it is 2 people that the state of an illness, which has the significant i.e. efficiently individual quantity that mitigates, without using
Invalid situation afterwards.Following table is that patient uses curative effect statistical form after liquid medicine.
| Therapeutic effect | Effectively | In vain | It cures |
| Number | 2 | 0 | 18 |
| Ratio | 10% | 0 | 90% |
As can be seen from the above table, rehabilitation medicinal liquor cure rate of the present invention can reach 90%, change conditions of patients
Kind ratio reaches absolutely, significant in efficacy, and cure rate is high.
Typical case
Zhao, male, 35 years old, often there is stiff, pain feeling in joint, took rehabilitation medicinal liquor two of the present invention
After the course for the treatment of, pain is substantially reduced, continues after taking two courses for the treatment of of liquid medicine of the present invention, feeling of pain thoroughly disappears, and can move freely.
Mr. Lin, male, 45 years old, lumbar vertebrae hyperosteogeny 5 years, there is lumbar vertebrae and lumbar soft tissue to ache, distending pain, it is stiff with
The symptom such as tired sense, and bend over to be limited, after four courses for the treatment of of rehabilitation medicinal liquor of the invention, effect is obvious, lumbar vertebrae and waist
Soft tissue no longer pain, can also be normally carried out and bend over.
To sum up, rehabilitation medicinal liquor of the invention is made of pure Chinese medicine, without any side effects, and treatment method is simple, is cured
It does not recur afterwards, at low cost, treatment cycle is short, is worth promoting, and can benefit patient.
Better embodiment of the invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (6)
1. a kind of bone hyperplasia rehabilitation medicinal liquor, which is characterized in that the liquid medicine is specifically made of following raw material: safflower, Cortex Eucommiae,
Radix Angelicae Sinensis, the root of straight ladybell, pure grain wine.
2. bone hyperplasia rehabilitation medicinal liquor according to claim 1, which is characterized in that every kilogram of pure grain wine in the liquid medicine
In contain following quality raw material: 18-21 grams of safflower, 17-22 grams of Cortex Eucommiae, 19-21 grams of Radix Angelicae Sinensis, 18-22 grams of the root of straight ladybell.
3. bone hyperplasia rehabilitation medicinal liquor according to claim 1, which is characterized in that every kilogram of pure grain wine in the liquid medicine
In contain following quality raw material: 20 grams of safflower, 20 grams of Cortex Eucommiae, 20 grams of Radix Angelicae Sinensis, 20 grams of the root of straight ladybell.
4. a kind of configuration method of bone hyperplasia rehabilitation medicinal liquor, including raw material as claimed in any one of claims 1-3, special
Sign is, the specific steps are as follows:
(1) raw material is chosen
The bulk pharmaceutical chemicals of safflower, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell are chosen, remove impurity, while preparing one kilogram of pure grain wine, it is spare；
(2) liquid medicine is brewed
One kilogram of pure grain wine in step (1) is poured into glassware, is then matched according to the quality of one kilogram of pure grain wine
Than weighing the safflower after removal impurity, Cortex Eucommiae, Radix Angelicae Sinensis, the root of straight ladybell, then the Chinese medicine after weighing is put into it is brewed in glassware, it is brewed
Time is 13-15 days, obtains required liquid medicine.
5. a kind of configuration method of bone hyperplasia rehabilitation medicinal liquor according to claim 4, which is characterized in that the step
(2) the specific dosage of liquid medicine obtained in is as follows: it is divided into four courses for the treatment of and uses, each course for the treatment of 8 days, twice daily, 13 milliliters every time.
6. a kind of configuration method of bone hyperplasia rehabilitation medicinal liquor according to claim 5, which is characterized in that the liquid medicine
Time of Administration is that half an hour takes after morning and evening dinner daily.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910467825.7A CN110051718A (en) | 2019-05-31 | 2019-05-31 | A kind of bone hyperplasia rehabilitation medicinal liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910467825.7A CN110051718A (en) | 2019-05-31 | 2019-05-31 | A kind of bone hyperplasia rehabilitation medicinal liquor |
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| Publication Number | Publication Date |
|---|---|
| CN110051718A true CN110051718A (en) | 2019-07-26 |
Family
ID=67325240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910467825.7A Pending CN110051718A (en) | 2019-05-31 | 2019-05-31 | A kind of bone hyperplasia rehabilitation medicinal liquor |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331983A (en) * | 2001-03-13 | 2002-01-23 | 曲丽萍 | Hyperosteogeny treating medicine |
| CN103655911A (en) * | 2013-12-31 | 2014-03-26 | 纪元元 | Traditional Chinese medicine for treating hyperostosis and method for preparing traditional Chinese medicine |
-
2019
- 2019-05-31 CN CN201910467825.7A patent/CN110051718A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331983A (en) * | 2001-03-13 | 2002-01-23 | 曲丽萍 | Hyperosteogeny treating medicine |
| CN103655911A (en) * | 2013-12-31 | 2014-03-26 | 纪元元 | Traditional Chinese medicine for treating hyperostosis and method for preparing traditional Chinese medicine |
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Application publication date: 20190726 |