CN110051555A - A kind of myristoyl pentapeptide -17 of generating hair and the composition of Wild soybean isoflavones - Google Patents
A kind of myristoyl pentapeptide -17 of generating hair and the composition of Wild soybean isoflavones Download PDFInfo
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- CN110051555A CN110051555A CN201910486104.0A CN201910486104A CN110051555A CN 110051555 A CN110051555 A CN 110051555A CN 201910486104 A CN201910486104 A CN 201910486104A CN 110051555 A CN110051555 A CN 110051555A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
It include Wild soybean isoflavones and myristoyl pentapeptide -17 in the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones the invention discloses the composition of a kind of myristoyl pentapeptide -17 of generating hair and Wild soybean isoflavones.Compared with the existing technology; the invention has the following advantages that the experiment of the composition transdermal stimulation of myristoyl pentapeptide -17 and Wild soybean isoflavones, skin sensibiligen experiment confirm in (1) present invention of the invention; non-stimulated to skin and acute toxic side effect, this proves that formula of the invention is safe, harmless.(2) present invention is confirmed through zoopery and human experimentation, can be effectively facilitated hair growth, be prevented hair loss.It can promote the growth of eyelashes and eyebrow.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of myristoyl pentapeptide -17 of generating hair and open country
The composition of isoflavones.
Background technique
Hair plays very important effect in the instrument modification of people, is a basic item for obtaining nature beauty in appearance
Part.Therefore, for hair tonic, hair care, hair care research, be constantly subjected to the very big attention of the world of medicine, cosmetics circle.In recent years, with
The development of society, living environment is seriously polluted, and psychological pressure increases and attention of the people to self-image, alopecia are more next
More become the disease that people from modern metropolitan cities is perplexed.
Wild soybean isoflavones, i.e. siskin isoflavonoid, are primarily present among pulse family, as content in the Fructus Sophorae, subprostrate sophora is larger.
GEN (Wild soybean isoflavones or genistein) and its glucoside member are the highest ingredients of content in isoflavones.Isoflavones
Aglycone forms it is higher than glycoside forms activity, especially GEN activity is higher, have phytoestrogen dual regulation.
MCF-7 cell is the Breast cancer lines of the ER positive, can specifically receive estrogen or estrogenic activity substance tune
It saves and is proliferated.Estrogen-like increment be it is very sensitive, it is simple and easy to do, can also distinguish between agonist and antagonist, thus extensive
Phytoestrogen applied to quick screening and evaluation environmental estrogens.With antioxidation, there is estrogen and resist female sharp
Disposition matter can inhibit the activity for opening up analysis foreign matter enzyme II, can inhibit the activity of tyrosine protein kinase PTK.
Myristoyl pentapeptide -17 (Myristoyl Pentapeptide-17) is that one kind effectively promotes eyelashes growth
Beauty win peptide, it can directly activate the expression of keratoprotein gene, promote keratoprotein to generate, and keratoprotein is by amino
Acid composition, it is related to control complicated interaction between the growth cycle of eyelashes and papilla and convex two tissues of hair, due to
The blood supply of nutrition is provided containing nerve and to eyelashes in papilla, and then grows eyelashes, becomes dense.
Have in the prior art much about hair tonic, educate the patent document of hair, such as Chinese patent literature CN105078827A
Disclose a kind of functions of nourishing hair and growing hair liquid containing shrubby sophora extract.Chinese patent literature CN103379898A discloses a kind of great Hua a species of orchid
The extract of the herb of blue illusion educates hair agent as the hair restorer of effective component.Chinese patent literature CN101291651A is disclosed
A kind of topical composition for hair growth.Chinese patent literature CN1212137C discloses a kind of for improving alopecia
Hair follice activating liquid.But the group about a kind of myristoyl pentapeptide -17 of generating hair of the invention and Wild soybean isoflavones
Closing object yet there are no report.
Summary of the invention
In order to overcome the deficiencies in the prior art described above place, it can sterilize but also wad a quilt with cotton the object of the present invention is to provide one kind
Myristoyl pentapeptide -17 and the composition of Wild soybean isoflavones of solidifying generating hair and preparation method thereof.
In order to achieve the above technical purposes, the technical solution adopted by the present invention is as follows: a kind of generating hair of the invention
Myristoyl pentapeptide -17 and Wild soybean isoflavones composition, the myristoyl pentapeptide -17 of the generating hair and
It include Wild soybean isoflavones and myristoyl pentapeptide -17 in the composition of Wild soybean isoflavones.
Further, it is wrapped in the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones
Containing isopropanol, glycerol (butanediol or panthenol), inositol, Wild soybean isoflavones, myristoyl pentapeptide -17, the tert-butyl alcohol, biology
Element, Tween-80, deionized water.
Further, the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones include
Following group of mass percent is grouped as:
Further, the composition packet of the myristoyl pentapeptide -17 of the generating hair and Wild soybean isoflavones
Following group for including mass percent is grouped as:
The myristoyl pentapeptide -17 of generating hair of the present invention and the composition of Wild soybean isoflavones are given birth in preparation
Develop the application in the cosmetics of hair.
The myristoyl pentapeptide -17 of generating hair of the present invention and the composition of Wild soybean isoflavones are anti-in preparation
Control the application in the cosmetics of alopecia.
A kind of preparation side of the composition of the myristoyl pentapeptide -17 and Wild soybean isoflavones of generating hair of the invention
Method includes the steps of determining that instrument and its specification and clean situation；By formula ratio by glycerol, inositol, the tert-butyl alcohol, Tween-80
It sequentially adds in corresponding amount deionized water, 25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring the different Huang of Wild soybean
Ketone, insulated and stirred 30-40min are down to room temperature, and myristoyl pentapeptide -17, biotin is added, stirs 30-40min at 25 DEG C,
Filtering, in an aseptic environment, in the cosmetic bottle after being fitted into disinfection, packaging.
Further, the room temperature is 25 DEG C.
Compared with the existing technology, the invention has the following advantages that
(1) in the present invention of the invention myristoyl pentapeptide -17 and Wild soybean isoflavones composition transdermal stimulation
Experiment, skin sensibiligen are it is experimentally confirmed that non-stimulated to skin and acute toxic side effect, this proves that formula of the invention is peace
Entirely, harmless.
(2) present invention is confirmed through zoopery and human experimentation, can be effectively facilitated hair growth, be prevented hair loss.It can be with
Promote the growth of eyelashes and eyebrow.
Specific embodiment
The present invention is further illustrated by the following examples.It should be understood that these embodiments are explainations of the invention
And citing, and the range that the invention is not limited in any way.
Comparative example 1
Product formula 1 (not plus myristoyl pentapeptide -17)
Unless otherwise instructed, percentage of the invention is weight percentage.Surplus is deionized water in product formula.
Prescription (1 kilogram of Essence)
Table 1
Preparation method
According to amount described in formula, by formula ratio by glycerol, inositol, the tert-butyl alcohol, Tween-80 sequentially add corresponding amount go from
In sub- water, 25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring Wild soybean isoflavones, insulated and stirred 30-
40min is down to room temperature (25 DEG C), and biotin is added, stirs 30-40min at 25 DEG C, filters, and in an aseptic environment, is packed into disinfection
In cosmetic bottle afterwards, packaging.
Comparative example 2
Product formula 2 (not plus Wild soybean isoflavones)
Prescription (1 kilogram of Essence)
Table 2
Preparation method
According to amount described in formula, glycerol, inositol, the tert-butyl alcohol are sequentially added in corresponding amount deionized water, 25 DEG C at the uniform velocity
10-15min is stirred, myristoyl pentapeptide -17, biotin is added, stirs 30-40min at 25 DEG C, filters, in gnotobasis
Under, in the cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 1
Product formula 3
Prescription (1 kilogram of Essence)
Table 3
Preparation method
According to amount described in formula, glycerol, inositol, the tert-butyl alcohol, Tween-80 are sequentially added in corresponding amount deionized water,
25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring Wild soybean isoflavones, insulated and stirred 30-40min is down to
Room temperature (25 DEG C) is added myristoyl pentapeptide -17, biotin, stirs 30-40min at 25 DEG C, filters, in an aseptic environment,
In cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 2
Product formula 4
Prescription (1 kilogram of Essence)
Table 4
Preparation method
According to amount described in formula, glycerol, inositol, the tert-butyl alcohol, Tween-80 are sequentially added in corresponding amount deionized water,
25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring Wild soybean isoflavones, insulated and stirred 30-40min is down to
Room temperature (25 DEG C) is added myristoyl pentapeptide -17, biotin, stirs 30-40min at 25 DEG C, filters, in an aseptic environment,
In cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 3
Product formula 5 (isopropanol makees solvent)
Prescription (1 kilogram of Essence)
Table 5
Preparation method
According to amounts described in formula, first isopropanol, Tween-80 are added to the container and are added with stirring Wild soybean isoflavones,
Heat preservation is mixed at 30 DEG C, inositol, the tert-butyl alcohol and glycerol is added, stirs 0.5-1h.
Test example 1
Skin irritatin, acute toxicity testing
One, experimental method
The black flower cavy 25 for taking healthy adult, is randomly divided into five groups, number 1-5, every group has 5.
Guinea pig skin processing: before experiment for 24 hours, the hair of tested guinea pig back backbone two sides is shaved off with scissors and shaver
About 4cm × 6cm area.
Medication and dosage: according to the experiment numbers of cavy, the cavy for being respectively 1 to number is used in embodiment 1
Formula 1, and so on the use of number 5 be formulated 5 etc.；Usage amount is 2ml, and sample liquid is uniformly applied to guinea pig back, and
It is covered with nonirritant plastic foil and two layers of gauze, then is fixed with nonirritant adhesive plaster, sample is licked with anti-dropout and animal
Liquid, the total topical application of drug is for 24 hours.Wash away sample liquid with warm water later, and later 2,12,24,48, the 7d of 72h observe guinea pig skin, hair
The performance of the systemic toxicity profiles such as hair, the variation and breathing of eye and mucous membrane, central nervous system, four limbs activity and death condition.
Two, experimental result
The tested area's skin of the cavy of five groups is showed no the stimulate the reactions such as erythema, oedema.
Within 7 days observation periods, cavy activity freely, the state of mind, appetite, no abnormality seen in terms of defecation, cavy without death,
Do not cause acute toxic reaction.
Test example 2
Hair regrowth zoopery
Using C57 mouse 50, the age 40-55 days, the hair of back of mice is rejected and weighed, then every 10 one group,
Five groups of number is 1-5, and the mouse of different weight is in every group of mean allocation, and then 1-5 will respectively using formula 1-5 by number
Sample liquid is applied to mouse unhairing region.That is, taking the composition sample of 0.1ml to be applied to back of mice (only smears unhairing region
One semi-area), smear within one day primary, continuous to smear 40 days, record smears specimen locations and newly grows hair and non-sample of smearing
Position newly grows the case where hair, and the two is compared.Experimental result is as shown in table 6:
Table 6
Experimental result is as shown in table 6, the results showed that the growth of myristoyl pentapeptide -17 and Wild soybean isoflavones to hair
Have more apparent effect, wherein -17 effect of myristoyl pentapeptide becomes apparent, can both share better effect.
Test example 3
Hair regrowth human experimentation
It is on probation to select formula 3 and formula 4.
20 people of volunteer for having serious 20 people of volunteer of alopecia, hair more sparse；It is therefrom each to select ten people to be divided at random
Two groups, number 1,2.The sample in formula 3,4 is taken, 1,2 group of use is given respectively, usage mode: after hair washing, after hair is dried, takes
Sample about 0.5ml is applied to alopecia position or hypotrichosis position, once in the morning and once at night, continues 2 months.Hair growth rate such as 7 institute of table
Show:
Table 7
As shown in table 7, as a result: being effectively improved using volunteer's hair of formula 3, wherein mostly having grown newly
Hair, and hair becomes thicker, stiffening, flexible.User of the user of formula 4 generally also such as formula 3 is similar, but its
Effect does not use the quick of formula 3.This illustrates that -17 content of myristoyl pentapeptide plays an important role to product.
Moreover, wherein there is part volunteer also more rare to eyebrow and eyelashes, after they are to corresponding site use,
It is effectively improved, more there is volunteer's eyebrow of half or so or eyelashes to become denser.
Embodiment 4
Formula 6
Prescription (1 kilogram of Essence)
Table 8
Preparation method
According to amount described in formula, butanediol, inositol, the tert-butyl alcohol, Tween-80 are sequentially added into corresponding amount deionized water
In, 25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring Wild soybean isoflavones, insulated and stirred 30-40min, drop
To room temperature (25 DEG C), myristoyl pentapeptide -17, biotin is added, stirs 30-40min at 25 DEG C, filters, in gnotobasis
Under, in the cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 5
Formula 7
Prescription (1 kilogram of Essence)
Table 9
Preparation method
According to amount described in formula, panthenol, inositol, the tert-butyl alcohol, Tween-80 are sequentially added in corresponding amount deionized water,
25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, are added with stirring Wild soybean isoflavones, insulated and stirred 30-40min is down to
Room temperature (25 DEG C) is added myristoyl pentapeptide -17, biotin, stirs 30-40min at 25 DEG C, filters, in an aseptic environment,
In cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 6
The myristoyl pentapeptide -17 of generating hair of the invention and the composition of Wild soybean isoflavones include quality percentage
Following group of ratio is grouped as:
The myristoyl pentapeptide -17 of generating hair of the present invention and the composition of Wild soybean isoflavones are given birth in preparation
Develop the application in the cosmetics of hair.
The myristoyl pentapeptide -17 of generating hair of the present invention and the composition of Wild soybean isoflavones are anti-in preparation
Control the application in the cosmetics of alopecia.
A kind of preparation side of the composition of the myristoyl pentapeptide -17 and Wild soybean isoflavones of generating hair of the invention
Method includes the steps of determining that instrument and its specification and clean situation；According to amount described in formula, by isopropanol, glycerol, flesh
Alcohol, the tert-butyl alcohol sequentially add in corresponding amount deionized water, and 25 DEG C are at the uniform velocity stirred 15min, are warming up to 50 DEG C, are added with stirring wild big
Beans isoflavones, insulated and stirred 30min are down to room temperature (25 DEG C), and myristoyl pentapeptide -17, biotin is added, stirs at 25 DEG C
35min, filtering, in an aseptic environment, and in the cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 7
The myristoyl pentapeptide -17 of generating hair of the invention and the composition of Wild soybean isoflavones include quality percentage
Following group of ratio is grouped as:
A kind of preparation side of the composition of the myristoyl pentapeptide -17 and Wild soybean isoflavones of generating hair of the invention
Method, it is characterised in that include the steps of determining that instrument and its specification and clean situation；By formula ratio by glycerol, inositol, tertiary fourth
Alcohol, Tween-80 sequentially add in corresponding amount deionized water, and 25 DEG C are at the uniform velocity stirred 10min, are warming up to 50 DEG C, are added with stirring open country
Isoflavones, insulated and stirred 35min are down to room temperature (25 DEG C), and myristoyl pentapeptide -17, biotin is added, stirs at 25 DEG C
30min is mixed, is filtered, in an aseptic environment, in the cosmetic bottle after being fitted into disinfection, packaging.
Embodiment 8
The myristoyl pentapeptide -17 of generating hair of the invention and the composition of Wild soybean isoflavones include quality percentage
Following group of ratio is grouped as:
A kind of preparation side of the composition of the myristoyl pentapeptide -17 and Wild soybean isoflavones of generating hair of the invention
Method, it is characterised in that include the steps of determining that instrument and its specification and clean situation；By formula ratio by glycerol, inositol, tertiary fourth
Alcohol, Tween-80 sequentially add in corresponding amount deionized water, and 25 DEG C are at the uniform velocity stirred 12min, are warming up to 50 DEG C, are added with stirring open country
Isoflavones, insulated and stirred 40min are down to room temperature (25 DEG C), and myristoyl pentapeptide -17, biotin is added, stirs at 25 DEG C
40min is mixed, is filtered, in an aseptic environment, in the cosmetic bottle after being fitted into disinfection, packaging.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this
The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, the present invention
Claimed range is delineated by the appended claims, the specification and equivalents thereof from the appended claims.
Claims (8)
1. a kind of myristoyl pentapeptide -17 of generating hair and the composition of Wild soybean isoflavones, it is characterised in that: described
It include Wild soybean isoflavones and myristoyl in the myristoyl pentapeptide -17 of generating hair and the composition of Wild soybean isoflavones
Base pentapeptide -17.
2. the myristoyl pentapeptide -17 of generating hair according to claim 1 and the composition of Wild soybean isoflavones,
Be characterized in that: in the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones comprising isopropanol,
Glycerol (butanediol or panthenol), inositol, Wild soybean isoflavones, myristoyl pentapeptide -17, the tert-butyl alcohol, biotin, Tween-80.
3. the myristoyl pentapeptide -17 of generating hair according to claim 1 and the composition of Wild soybean isoflavones,
Be characterized in that: the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones include quality percentage
Following group of ratio is grouped as:
4. the myristoyl pentapeptide -17 of generating hair according to claim 1 and the composition of Wild soybean isoflavones,
Be characterized in that: the myristoyl pentapeptide -17 of the generating hair and the composition of Wild soybean isoflavones include quality percentage
Following group of ratio is grouped as:
5. prepared by the myristoyl pentapeptide -17 of generating hair described in claim 1 and the composition of Wild soybean isoflavones
Application in the cosmetics of generating hair.
6. prepared by the myristoyl pentapeptide -17 of generating hair described in claim 1 and the composition of Wild soybean isoflavones
Prevent and treat the application in the cosmetics of alopecia.
7. a kind of preparation method of the composition of the myristoyl pentapeptide -17 and Wild soybean isoflavones of generating hair, feature
It is to include the steps of determining that instrument and its specification and clean situation；By formula ratio by glycerol, inositol, the tert-butyl alcohol, tween-
80 sequentially add in corresponding amount deionized water, and 25 DEG C are at the uniform velocity stirred 10-15min, are warming up to 50 DEG C, it is different to be added with stirring Wild soybean
Flavones, insulated and stirred 30-40min are down to room temperature, and myristoyl pentapeptide -17, biotin is added, stirs 30- at 25 DEG C
40min, filtering, in an aseptic environment, and in the cosmetic bottle after being fitted into disinfection, packaging.
8. the combination of the myristoyl pentapeptide -17 and Wild soybean isoflavones of a kind of generating hair according to claim 7
The preparation method of object, it is characterised in that: the room temperature is 25 DEG C.
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| US6017893A (en) * | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
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| US20170049689A1 (en) * | 2015-08-21 | 2017-02-23 | Gratia Mundi Gmbh | Active combinations, compositions and methods for enhancing hair growth |
| CN109512744A (en) * | 2018-12-29 | 2019-03-26 | 广州博科健康科技集团有限公司 | A kind of eyelashes growth-promoting media and preparation method thereof |
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2019
- 2019-06-05 CN CN201910486104.0A patent/CN110051555A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017893A (en) * | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
| CN101757013A (en) * | 2008-12-25 | 2010-06-30 | 狮王株式会社 | Hair-growing agent composition |
| US20170049689A1 (en) * | 2015-08-21 | 2017-02-23 | Gratia Mundi Gmbh | Active combinations, compositions and methods for enhancing hair growth |
| CN109512744A (en) * | 2018-12-29 | 2019-03-26 | 广州博科健康科技集团有限公司 | A kind of eyelashes growth-promoting media and preparation method thereof |
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| Title |
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| 孙贵范著: "《助力癌症康复 1825+癌症的自然医学疗法策略 2018版》", 31 July 2018 * |
| 张君坦等: "《头发养护与脱发防治180问》", 31 January 2017 * |
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