CN110051365A - A kind of implanted electrode for continuing to monitor for a long time - Google Patents
A kind of implanted electrode for continuing to monitor for a long time Download PDFInfo
- Publication number
- CN110051365A CN110051365A CN201910326629.8A CN201910326629A CN110051365A CN 110051365 A CN110051365 A CN 110051365A CN 201910326629 A CN201910326629 A CN 201910326629A CN 110051365 A CN110051365 A CN 110051365A
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- Prior art keywords
- layer
- electrode
- monitor
- continuing
- long time
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
Abstract
The invention discloses a kind of implanted electrodes for continuing to monitor for a long time, including basal electrode, sensing chamber, insulating layer, connecting terminal and piercing portion.The sensing chamber is located in the middle part of electrode, and both ends are coated by insulating layer, forms both ends height, intermediate low structure, sensing intracavitary portion includes spiral functional layer, signal enhancement layer, bearing bed, signals layer and separation layer.Implanted electrode provided by the present invention for continuing to monitor for a long time can manually be pierced into human body skin corium, continue to monitor the variation of blood glucose in body fluid.Have many advantages, such as that simple and compact for structure, monitoring time is long, easy to operate, mitigation is implanted into wound and sensing film layer is avoided to fall off.
Description
[technical field]
The invention patent relates to medical monitoring equipment technical field, in particular to subcutaneous duration blood sugar monitoring micropin electricity
Pole.
[background technique]
It is counted according to International Diabetes Federation (IDF), illness rate of the whole world diabetes in 20~79 years old adult is at present
8.8%, it is contemplated that 10.4% will be risen to the year two thousand forty.Diabetes rate of propagation is fast, and there are about 5,000,000 people to die of diabetes every year
And its related complication, the 14.5% of All-cause death number is accounted for, 8.39% compared with 2013, which has, to be dramatically increased.Wherein, China
It is ranked the first in the world with 1.096 hundred million numbers of patients, it is contemplated that 1.51 hundred million will be risen to the year two thousand forty, because the number of Diabetes Death is every
Year surpasses 1,000,000.
But investigation discovery, the treatment rate of China diabetic is only 25.8%, since the harm of diabetes essentially consists in
Therefore all kinds of complication being induced by it fail the invasion that patient receiving treatment is more subject to complication.And according to Sino-British section
The current research of scholar is shown, compared with aglycosuria patient, the average life span of China maturity-onset diabetes patient will shorten 9 years.
Currently, being by lifestyle modification, stem-cell therapy and personalized drug therapy for the treatment of diabetes
The methods of the blood glucose level of patient is maintained within normal range to reach different degrees of alleviation, there has been no what can be eradicated completely
Method.More traditional finger blood measurement method is more apparent to the control effect of blood glucose, but because it is unable to early warning and discovery height blood
The huge Nocturnal hypoglycemia of sugar, especially damage to the body and hypoglycemia unawareness, therapeutic effect have certain limitation.It is dynamic
State glucose monitoring techniques are significant for alleviating diabetes can reflect and predict the advantage of blood glucose fluctuation feature.But
For Most patients, Dynamic Blood Glucose Monitoring product is mostly import, and a sensor is only capable of monitoring 7 days or so, Wu Fashi
Existing long term monitoring, more emat sensor can bring the risk and heavy financial burden of infection repeatedly.
For this purpose, the applicant devises a kind of implanted electrode for continuing to monitor for a long time, electrode passes through design cavity
Formula spiral detecting means, it is intended to design patient can easily use, the sensing electrode of long term monitoring, improve the compliance of patient, make blood
Sugared concentration remains stable for a long time, far from hyperglycemia and its complication.
[summary of the invention]
The invention patent in view of the above-mentioned drawbacks of the prior art, devise it is a kind of it is simple and compact for structure, can be for a long time
The implanted electrode for continuing to monitor for a long time monitor, be easy to hand operation, can mitigate implantation wound, facilitates blood sugar disorders
Patient realizes self-monitoring, stability contorting blood sugar concentration.
A kind of implanted electrode for continuing to monitor for a long time includes basal electrode, sensing chamber, insulating layer, connecting terminal,
Piercing portion；The basal electrode material is rigid metal, and shape is needle-like, and between 0.1~0.5mm, length is less than diameter
10cm；The insulating layer material is insulating polymer material, is coated on the region other than sensing chamber；Sensing chamber is located in electrode
Portion, both ends are coated by insulating layer, form both ends height, intermediate low structure, inside includes spiral functional layer, signal enhancement layer, holds
Carrier layer, signals layer, separation layer.
Spiral functional layer material is noble metal decorated on basal electrode；Signal enhancing layer material is noble metal nano
Grain is modified in spiral functional layer and basal electrode；Carrying layer material is functional high molecule material；Signal layer material is reaction
Any one or more combination in catalytic materials；Insolated layer materials are any one of the high molecular material with biocompatibility
Or multiple combinations；Piercing portion surface applies layer of cloth and separation layer.
The insulating layer is coated on the other parts in addition to sensing chamber, and thickness is greater than sensing chamber.
The material of the spiral functional layer is one of noble metals such as gold, platinum, platinoiridita or multiple combinations.
The carrying layer material is functional high molecule material, selects Nafion, cellulose acetate, polyaniline, poly- pyrrole
It coughs up, any one or more combination in polyphenol and its derivative.
The piercing portion surface applies layer of cloth and separation layer, and when coating does not change the shape of point.
Compared with prior art.The present invention has the advantages that
1. a kind of implanted electrode for continuing to monitor for a long time of the invention, by selecting the stronger material conduct of rigidity
Basal electrode directly can manually be implanted into, and can mitigate the wound in implantation process, alleviate during patient's use
The psychological burden of patient, improves the compliance of product, and then has pushed Dynamic Blood Glucose Monitoring product in China diabetic
In use.
2. a kind of implanted electrode for continuing to monitor for a long time of the invention winds base by using superfine precious metal
Hearth electrode, which constitutes screw type functional layer one, can be increased the body surface area ratio of electrode, to increase compared with traditional needle electrode
It is fixed the quantity of glucose oxidase, and the electrology characteristic of stainless steel can be improved, and then improves the signal-to-noise ratio of electrode and accurate
Degree.
3. a kind of implanted electrode for continuing to monitor for a long time of the invention forms pin type sensing by using insulating layer
Chamber can protect fixed enzyme layer in sensor monitoring process, and can keep being implanted into rigidity while cuts down the acutance of needle point, has
Effect alleviates the strong foreign body reaction because causing after sharpened tip implantation, and then improves the monitoring service life of sensor.
[Detailed description of the invention]
Fig. 1 is the implanted electrode sensor region partition structure figure for continuing to monitor for a long time
In Fig. 1:
1-basal electrode, 2-sensing chambers, 3-insulating layers, 4-connecting terminals, 5-spiral functional layers, 6-signal enhancings
Layer, 7-bearing beds, 8-signals layers, 9-separation layers, 10-piercing portions.
[specific embodiment]
The present invention is described in further details below with reference to Figure of description and specific embodiment.
As shown in Figure 1, a kind of implanted electrode for continuing to monitor for a long time includes: basal electrode 1, sensing chamber 2, insulation
Layer 3, connecting terminal 4, piercing portion 10；The sensing chamber 2 includes spiral functional layer 5, signal enhancement layer 6, bearing bed 7, signals layer
8, separation layer 9.
1 material of basal electrode is rigid metal, and shape is needle-like, and for diameter between 0.1~0.5mm, length is less than 10cm；
Institute's insulating layer material is insulating polymer material, is coated on the region other than sensing chamber 2；5 material of spiral functional layer is noble metal
Modification is on basal electrode 1；6 material of signal enhancement layer is noble metal nano particles, is modified in spiral functional layer 5 and basal electrode
On 1；7 material of bearing bed is functional high molecule material；8 material of signals layer is any one or more group in catalytic reaction object
It closes；9 material of separation layer is any one or more combination of the high molecular material with biocompatibility；10 surface of piercing portion applies
Layer of cloth 3 and separation layer 9.
Wherein, the platinum nano-layers are prepared by way of electro-deposition, select the electrolyte of various concentration proportion
With sedimentation potential platinum electrodeposition nano particle, concentration of electrolyte and current potential to Pt nanoparticle diameter, configuration of surface and its
Platinum layer compactness has a major impact.
The bearing bed takes different capacity to sensing chamber by drop, wherein drop taken amount influences thicknesses of layers and then shadow
Ring body surface area ratio and active site.
By controlling the distribution of signal enhancement layer and the thickness of bearing bed, is formed and adapt to catalytic specie size in signals layer
Aperture structure to provide higher body surface area than fixing excessive catalytic materials in more stable mode, and then improves sensing
The monitoring service life of device mitigates patient because of the frequently feared state of mind and financial burden caused by more emat sensor.
It should be noted that above embodiments are only to illustrate the unarmed implanted spiral micropin sensing electrode of the invention patent
Illustrate, rather than the restriction to the invention patent.Those skilled in the art should understand that can be to the technology of the design
Scheme is modified or replaced equivalently, and without departing from the spirit and scope of the technical solution of the present invention, should all be covered in this hair
In bright scope of the claims.
Claims (7)
1. a kind of implanted electrode for continuing to monitor for a long time, which is characterized in that the electrode includes basal electrode (1), passes
Feel chamber (2), insulating layer (3), connecting terminal (4), piercing portion (10)；The sensing chamber (2) is located in the middle part of electrode, and both ends are by insulating
Layer cladding forms both ends height, intermediate low structure；The sensing chamber (2) include spiral functional layer (5), signal enhancement layer (6),
Bearing bed (7), signals layer (8), separation layer (9)；Spiral functional layer (5) material is noble metal decorated in basal electrode (1)
On；Signal enhancement layer (6) material is noble metal nano particles, is modified in spiral functional layer (5) and basal electrode (1)；
Signals layer (8) material is any one or more combination in catalytic reaction object；Separation layer (9) material is hydrophily
Any one or more combination of functional material；Piercing portion (10) the surface even spread insulating protective layer (3) and separation layer
(9)。
2. the implanted electrode as described in claim 1 for continuing to monitor for a long time, it is characterised in that: the basal electrode
(1) material is rigid metal, and shape is needle-like, and for diameter between 0.1~0.5mm, length is less than 10cm.
3. the implanted electrode as described in claim 1 for continuing to monitor for a long time, it is characterised in that: the insulating layer
(3) material is insulating polymer material, is coated on the region other than sensing chamber (2).
4. the implanted electrode as described in claim 1 for continuing to monitor for a long time, it is characterised in that: the insulating layer
(3) coating thickness is greater than sensing chamber (2).
5. the implanted electrode as described in claim 1 for continuing to monitor for a long time, it is characterised in that: the spiral function
The material of layer (5) is one of noble metals such as gold, platinum, platinoiridita or multiple combinations.
6. the implanted electrode as claimed in claim 2 for continuing to monitor for a long time, the bearing bed (7) material is function
Property high molecular material, select Nafion, cellulose acetate, polyaniline, polypyrrole, any one in polyphenol and its derivative
Or multiple combinations.
7. the implanted electrode as claimed in claim 2 for continuing to monitor for a long time, it is characterised in that: the piercing portion table
Face applies layer of cloth and separation layer, and when coating does not change the shape of point.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910326629.8A CN110051365A (en) | 2019-04-23 | 2019-04-23 | A kind of implanted electrode for continuing to monitor for a long time |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910326629.8A CN110051365A (en) | 2019-04-23 | 2019-04-23 | A kind of implanted electrode for continuing to monitor for a long time |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110051365A true CN110051365A (en) | 2019-07-26 |
Family
ID=67320101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910326629.8A Pending CN110051365A (en) | 2019-04-23 | 2019-04-23 | A kind of implanted electrode for continuing to monitor for a long time |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102920465A (en) * | 2012-10-26 | 2013-02-13 | 浙江大学 | Glucose sensor |
| CN103328650A (en) * | 2011-01-20 | 2013-09-25 | 美敦力迷你迈德公司 | Layered enzyme compositions for use with analyte sensors |
| CN103462615A (en) * | 2013-09-13 | 2013-12-25 | 上海移宇科技有限公司 | Micrometer-scale glucose sensor microelectrode |
| CN104622480A (en) * | 2013-11-12 | 2015-05-20 | 上海移宇科技有限公司 | Single-needle integrated artificial pancreas |
| US20170173216A1 (en) * | 2006-06-22 | 2017-06-22 | University Of South Florida | Collagen scaffolds, medical implants with same and methods of use |
| CN109406589A (en) * | 2018-11-23 | 2019-03-01 | 浙江大学 | A kind of implanted blood sugar test probe and its production method based on silk-screen printing |
-
2019
- 2019-04-23 CN CN201910326629.8A patent/CN110051365A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170173216A1 (en) * | 2006-06-22 | 2017-06-22 | University Of South Florida | Collagen scaffolds, medical implants with same and methods of use |
| CN103328650A (en) * | 2011-01-20 | 2013-09-25 | 美敦力迷你迈德公司 | Layered enzyme compositions for use with analyte sensors |
| CN102920465A (en) * | 2012-10-26 | 2013-02-13 | 浙江大学 | Glucose sensor |
| CN103462615A (en) * | 2013-09-13 | 2013-12-25 | 上海移宇科技有限公司 | Micrometer-scale glucose sensor microelectrode |
| CN104622480A (en) * | 2013-11-12 | 2015-05-20 | 上海移宇科技有限公司 | Single-needle integrated artificial pancreas |
| CN109406589A (en) * | 2018-11-23 | 2019-03-01 | 浙江大学 | A kind of implanted blood sugar test probe and its production method based on silk-screen printing |
Non-Patent Citations (1)
| Title |
|---|
| 潘帅等: "基于表面重建螺旋型铂铱电极的葡萄糖生物传感器", 《高等学校化学学报》 * |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190726 |
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