CN110022179A - A kind of pumping signal processing system for brain edema monitor - Google Patents
A kind of pumping signal processing system for brain edema monitor Download PDFInfo
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- CN110022179A CN110022179A CN201910295373.9A CN201910295373A CN110022179A CN 110022179 A CN110022179 A CN 110022179A CN 201910295373 A CN201910295373 A CN 201910295373A CN 110022179 A CN110022179 A CN 110022179A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04B—TRANSMISSION
- H04B17/00—Monitoring; Testing
- H04B17/0082—Monitoring; Testing using service channels; using auxiliary channels
- H04B17/0085—Monitoring; Testing using service channels; using auxiliary channels using test signal generators
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Abstract
This application discloses a kind of pumping signal processing systems for brain edema monitor, including control system, for configuring and controlling and receiving circuit and transmit circuit；Transmit circuit, for sending pumping signal to human body head according to the instruction of control system；Circuit is received, for receiving the signal obtained from human body head, and control system is sent a signal to and is handled；DDS signal generator, for generating pumping signal；Treated pumping signal by sender electrode or transmit coil is sent to human body head for amplifying to pumping signal and filter by transmitter；Differential amplifier circuit, for obtaining the signal of receiving electrode or receiving coil；Receiver, the signal for exporting differential amplifier circuit amplify and filter, and, by treated, signal is sent to control system.The technical solution of the application can detect the variation of cerebral tissue using differential impedance, improve sensitivity of the brain edema monitor to skull surface potential monitoring.
Description
Technical field
This application involves analysis and survey control technology field more particularly to a kind of excitation letters for brain edema monitor
Number processing system.
Background technique
Brain edema is brain tissue to cerebrovascular disease, dysbolism, infection, neoformation, poisoning and traumatic cerebral disease etc.
Pathology and Pathophysiology reaction, be critical complication caused by the above-mentioned various causes of disease；Brain water content increases when brain edema,
Brain volume increase, and then cause intracranial pressure raisings, brain displacement, concurrent hernia cerebri and cause a disease people death.Clinically, brain edema is to cause
The main reason for cerebral disease patient is dead.Identification brain edema in time carries out rationally correctly treatment brain edema and evaluation brain in time
Edema therapeutic effect, to saving, patient vitals are most important.The severity of brain edema is digitized, this is to clinically evaluating
Treatment brain edema has very important effect.
According to electromagnetic field basic theories, from head surface to encephalic Injection Current, a current field is formed in encephalic, just
Under normal state, current field is evenly distributed and stablizes.If having oedema or hemotoncus lesion in encephalic, encephalic current field will be formed
Interference, electric current field distribution by no longer uniformly and change with the variation of lesion, by test skull surface current potential and its
Variation, can reflect out the physical characteristic and its changing rule of intracranial lesion, to achieve the effect that monitoring.
However current brain edema monitor is small to the monitoring sensitivity of skull surface current potential, therefore, how to improve its prison
Surveying sensitivity becomes those skilled in the art's urgent problem to be solved.
Summary of the invention
This application provides a kind of pumping signal processing systems for brain edema monitor, and brain edema monitoring can be improved
Monitoring sensitivity of the instrument to skull surface current potential.
This application provides a kind of pumping signal processing systems for brain edema monitor, comprising:
Control system, for configuring and controlling and receiving circuit and transmit circuit；
The transmit circuit, for sending pumping signal to human body head according to the instruction of the control system；
The signal for receiving the signal obtained from human body head, and is sent to the control by the reception circuit
System is handled；
The transmit circuit includes DDS signal generator and the transmitter that connect with the DDS signal generator；
The DDS signal generator, for generating pumping signal；
The transmitter, for the pumping signal to be amplified and filtered, by treated, pumping signal is electric by sending
Pole or transmit coil are sent to human body head；
The receiver for receiving circuit and including differential amplifier circuit and being connect with the differential amplifier circuit；
The differential amplifier circuit, for obtain receiving electrode perhaps the signal receiving electrode of receiving coil or
Receiving coil is respectively at least one set, includes two receiving electrodes or two receiving coils in one group, and one group of reception is electric
The corresponding position in two sides that pole or one group of receiving coil are individually positioned in human body head；
The receiver, the signal for exporting the differential amplifier circuit amplify and filter, and, by treated
Signal is sent to the control system.
Optionally, the quantity of the sender electrode or transmit coil distinguishes 1, and the either side of human body head is arranged in.
Optionally, the system also includes switching network, the switching network respectively with the transmit circuit,
The reception circuit, the sender electrode or transmit coil are connected with the receiving electrode or receiving coil.
Optionally, the pumping signal is the pulse signal of predetermined pulse width range and predetermined pulse repetition rate.
Optionally, the pulse signal is pulse, pulse train or coded pulse sequence.
Optionally, the control system includes computer, microprocessor, digital signal processor or FPGA.
Optionally, the system also includes analog-digital converter, the analog-digital converter is connect with the receiver, and being used for will
The analog signal of the receiver output is converted into digital signal.
From the above technical scheme, this application provides a kind of pumping signal processing systems for brain edema monitor
System, including control system, for configuring and controlling and receiving circuit and transmit circuit；Transmit circuit, for according to control system
It instructs to human body head and sends pumping signal；Circuit is received, for receiving the signal obtained from human body head, and signal is sent
It is handled to control system；Transmit circuit includes DDS signal generator and the transmitter that is attached thereto；DDS signal generator,
For generating pumping signal；Transmitter, for amplifying to pumping signal and filtering, by treated, pumping signal is electric by sending
Pole or transmit coil are sent to human body head；Receive the receiver that circuit includes differential amplifier circuit and is attached thereto；Difference
Amplifying circuit, for obtaining the signal of receiving electrode or receiving coil；Receiver, the letter for exporting differential amplifier circuit
Number amplifies and filter, and, it will treated that signal is sent to control system.The technical solution of the application can obtain excitation letter
Number by the signal after brain tissue, the variation of cerebral tissue is detected using differential impedance, improves brain edema monitor to skull
The sensitivity of surface potential monitoring.
Detailed description of the invention
In order to illustrate more clearly of the technical solution of the application, attached drawing needed in case study on implementation will be made below
Simply introduce, it should be apparent that, for those of ordinary skills, in the premise of not making the creative labor property
Under, it is also possible to obtain other drawings based on these drawings.
Fig. 1 is that a kind of structure of the pumping signal processing system for brain edema monitor provided by the embodiments of the present application is shown
It is intended to；
Fig. 2 is the circuit structure diagram of DDS signal generator provided by the embodiments of the present application；
Fig. 3 is the circuit structure diagram of transmitter provided by the embodiments of the present application；
Fig. 4 is the circuit structure diagram of differential amplifier circuit provided by the embodiments of the present application；
Fig. 5 is the circuit structure diagram of analog-digital converter provided by the embodiments of the present application；
Fig. 6 is the circuit structure diagram of the first switching network provided by the embodiments of the present application；
Fig. 7 is the circuit structure diagram of second of switching network provided by the embodiments of the present application；
Fig. 8 is the circuit structure diagram of the third switching network provided by the embodiments of the present application；
Fig. 9 is the circuit structure diagram of the 4th kind of switching network provided by the embodiments of the present application；
Figure 10 is human body head electrode scheme of installation provided by the embodiments of the present application.
It illustrates:
Wherein, 1- control system；2- transmit circuit；3- receives circuit；21-DDS signal generator；22- transmitter；31-
Differential amplifier circuit；32- receiver；6- emission electrode；The first receiving electrode of 7-；8- ground terminal；The second receiving electrode of 9-.
Specific embodiment
In order to make those skilled in the art better understand the technical solutions in the application, below in conjunction with attached drawing, it is right
Technical solution in the embodiment of the present application is clearly and completely described.
Referring to Fig. 1, the embodiment of the present application provides a kind of pumping signal processing system for brain edema monitor, packet
It includes:
Control system 1, for configuring and controlling and receiving circuit 3 and transmit circuit 2, and according to the signal for receiving circuit 3
Amplitude, the phase etc. for calculating differential impedance estimate the state of brain edema according to the amplitude of calculating, phase etc..
The transmit circuit 2, for sending pumping signal to human body head according to the instruction of the control system 1.
The signal for receiving the signal obtained from human body head, and is sent to the control by the reception circuit 3
System 1 is handled.
The transmit circuit 2 includes DDS signal generator 21 and the transmitter connecting with the DDS signal generator 21
22。
The DDS signal generator 21, for generating pumping signal；And the circuit knot of the DDS signal generator 21
Structure is as shown in Figure 2, wherein the pin 1 of DDS signal generator U17 is connected to the end AGND, pin 2 and pin 3 by resistance R47
Route after being connected and connecting is connected to the end AGND by capacitor C96, and pin 16 is connected to one end of capacitor C93, pin 15
Be connected to the other end of capacitor C93, pin 14, pin 12, pin 11 and pin 11 respectively by resistance R65, R51, R52 and
R53 is connected to the end AGND, and the pin 3 of crystal oscillator U13 is connect with the pin 9 of U17, provides clock signal clk 1 for U17；DDS signal
The 14 output signal VSINE of pin of generator U17, input of the signal as transmitter 22.
The transmitter 22, for the pumping signal to be amplified and filtered, by treated, pumping signal is sent to people
Body head；And the circuit structure of the transmitter 22 is as shown in figure 3, signal VSINE is input signal, output signal II
IN1。
The receiver 32 for receiving circuit 3 and including differential amplifier circuit 31 and being connect with the differential amplifier circuit 31.
The differential amplifier circuit 31, for obtaining the signal of receiving electrode or receiving coil, the receiving electrode or
Person's receiving coil is respectively at least one set, includes two receiving electrodes or two receiving coils in one group, and one group of reception
The corresponding position in two sides that electrode or one group of receiving coil are individually positioned in human body head；And the differential amplification electricity
The circuit structure on road 31 is as shown in Figure 4, wherein is passed through respectively by the signal that two receiving electrodes or two receiving coils obtain
The end D_IN+ and the input of the end D_IN-, the signal VIN after differential amplification are exported from the pin 7 of difference amplifier U27.In addition,
Multiple groups receiving electrode or multiple groups receiving coil can also be set in the application, and its object is to can be obtained according to different location
Signal, obtain additional information about brain situation, while being also convenient for flexibly obtaining signal.
The receiver 32, the signal for exporting the differential amplifier circuit 31 amplify and filter, and, it will handle
Signal afterwards is sent to the control system 1.
Optionally, the system also includes analog-digital converter, the analog-digital converter connect with the receiver 32, is used for
Digital signal is converted by the analog signal that the receiver 32 exports, and, the circuit structure of analog-digital converter such as Fig. 5 institute
Show, wherein the input signal VIN of analog-digital converter is the output signal VIN of differential amplifier circuit, the output letter of analog-digital converter
It is exported number respectively by the pin 15 of module U30 and pin 16, is finally acquired to be input in control system 1 and calculate point
Analysis.
Optionally, the system also includes switching network, the switching network respectively with the transmit circuit
2, the reception circuit 3, the sender electrode or transmit coil are connected with the receiving electrode or receiving coil.Can first by
Perhaps receiving coil and sender electrode or transmit coil access in switching network all receiving electrodes, switching
Network accesses transmit circuit 2 again and receives which electrode circuit 3 selects the characteristics of can switching using switching network
Perhaps when coil connect the quantity more than two when receiving electrode or receiving coil with transmit circuit 2 and reception circuit 3, switch
Arbitrary two electrodes can be formed one group of new receiving electrode by handover network, or arbitrary two coils are formed new one
Group receiving coil can obtain the signal that the brain tissue of each different location is propagated in this way, so that the result of test is more comprehensive.
Specifically, the circuit structure of switching network is respectively as shown in Fig. 6,7,8 and 9.
Fig. 6 is the case where switching network is connect with sender electrode or transmit coil, wherein the pipe of switching module U4
The input signal of foot 3 is the output signal II IN1 of transmitter 22, and pin 13,14,15,12,1 and 5 outputs signal to transmission electricity
Pole or transmit coil.
Switching module U5 in Fig. 7 makes some connecting with any of its pin 13,14,15,12,1 and 5 pin
Electrode or coil ground connection, ground signalling are provided by pin 3.
Switching module U14 and U15 in Fig. 8 and Fig. 9 obtain receiving electrode from pin 13,14,15,12,1 and 5 respectively
Or the signal D_IN+ and D_IN- of receiving coil detection, and the two signals are sent to differential amplifier circuit 31 as input
Signal.
Further, according to the structure of above-mentioned Fig. 6-Fig. 9, by taking Figure 10 as an example, it can show and be installed on human body head
The schematic diagram of electrode.
Optionally, the pumping signal is the pulse signal of predetermined pulse width range and predetermined pulse repetition rate.
Optionally, the pulse signal is pulse, pulse train or coded pulse sequence.
Optionally, the control system 1 includes computer, microprocessor, digital signal processor or FPGA.
The process flow of entire signal is as follows in the system of the application:
Control system 1 configures DDS signal generator 21 and generates electric excitation signal, is motivated by the amplification of transmitter 22, filtering
Signal is transmitted to switching network；Control system 1 is arranged switching network and selects different electrode combination or coil group
Any of it closes, setting each of electrode or coil may be connected to transmit circuit 2 and receive circuit 3；Two connect
It receives the signal that electrode or coil receive to amplify and filter by difference amplifier 31 and receiver 32, passes to mould after receiving signal
Number conversion module is finally sending back control system 1, is carrying out data analysis.
The system application differential impedance of the application changes to detect cerebral tissue.The biological tissue of brain includes skin, head
Bone, celiolymph (CSF), ectocinerea and white matter and blood vessel and blood etc..These tissues are respectively with the conductivity of its own
And dielectric constant, and the wherein conductivity highest of CSF.Cerebral tissue can show at different frequencies different conductivity and
Dielectric constant, with the increase of cephalledema volume, the volume of CSF can reduce, and the impedance on head can change, therefore difference
Impedance will change, by with variable-width pulse or repetition pulse sequence or other coding waves be sent to cerebral tissue,
It is obtained with the broadband response of cerebral tissue, further detects the change value of differential impedance.
Cerebral tissue dielectric constant when wave frequency is in 1KHz is 1,000,000, and in 10KHz, dielectric constant is up to ten thousand,
Dielectric constant is many thousands of when 100KHz, and dielectric constant is less than 100 when to 100MHz.And the dielectric constant of blood is also than brain
Height, and dielectric constant of the water in low frequency is 80 and drops in several GHz several.Since dielectric constant is very different in low frequency,
The time difference of low frequency is much bigger, therefore the phase of low frequency can also can reflect big differing dielectric constant.The energy of single pulse
Spectrum concentration is measured in low frequency part, when pulse is used as pumping signal, can study and the tissue of extremely low frequency range is rung
It answers, Y-PSNR (SNR) can increase；Pulse train is equivalent to the excitation in a lasting observation period, it is possible to reduce single
The error of secondary measurement improves the accuracy of measurement.
Coded pulse sequence is combined with selected pulse width with selected binary code and is encoded, and improves the anti-of system
Interference performance, while error correcting code etc. being added in coding, it can detect whether data pass mistake in receiving end, to increase brain water
Swollen monitoring sensitivity and accuracy.
It is pulse or pulse train or coded pulse sequence that control system, which can configure output drive signal,.According to a large amount of
The most effective response section of feedback is tested, it is specified that pulse width range is 2us -100ms, broadband response is bright in this section
It is aobvious, significant effect；Pulse recurrence frequency ensures that lasting pulse or single pulse have between 100Khz--300Khz in this way
Apparent comparison reference, with observe the generation of response, duration and whether linear response results.
Relative to traditional pumping signal be sine wave the case where, sine wave is a kind of frequency content letter the most single
Number, response results are single, are easy by noise jamming；And pumping signal be impulse wave when, pulse envelope containing more frequency spectrums letter
Number, there are better spectral response curve, and strong antijamming capability, accuracy is high.
From the above technical scheme, this application provides a kind of pumping signal processing systems for brain edema monitor
System, including control system 1, for configuring and controlling and receiving circuit 3 and transmit circuit 2；Transmit circuit 2, for being according to control
The instruction of system 1 sends pumping signal to human body head；Circuit 3 is received, for receiving the signal obtained from human body head, and will letter
Number being sent to control system 1 is handled；Transmit circuit 2 includes DDS signal generator 21 and the transmitter 22 being attached thereto；
DDS signal generator 21, for generating pumping signal；Transmitter 22, for amplifying to pumping signal and filtering, by treated
Pumping signal is sent to human body head by sender electrode or transmit coil；Receiving circuit 3 includes 31 He of differential amplifier circuit
The receiver 32 being attached thereto；Differential amplifier circuit 31, for obtaining the signal of receiving electrode or receiving coil；Receiver
32, the signal for exporting differential amplifier circuit 31 amplifies and filters, and, by treated, signal is sent to control system
1.The technical solution of the application can obtain pumping signal by the signal after brain tissue, and brain group is detected using differential impedance
The variation knitted improves sensitivity of the brain edema monitor to skull surface potential monitoring.
The application can be used in numerous general or special purpose computing system environments or configuration.Such as: personal computer, service
Device computer, handheld device or portable device, laptop device, multicomputer system, microprocessor-based system, top set
Box, programmable consumer-elcetronics devices, network PC, minicomputer, mainframe computer, including any of the above system or equipment
Distributed computing environment etc..
The application can describe in the general context of computer-executable instructions executed by a computer, such as program
Module.Generally, program module includes routines performing specific tasks or implementing specific abstract data types, programs, objects, group
Part, data structure etc..The application can also be practiced in a distributed computing environment, in these distributed computing environments, by
Task is executed by the connected remote processing devices of communication network.In a distributed computing environment, program module can be with
In the local and remote computer storage media including storage equipment.
Those skilled in the art will readily occur to its of the application after considering specification and practicing application disclosed herein
Its embodiment.This application is intended to cover any variations, uses, or adaptations of the application, these modifications, purposes or
Person's adaptive change follows the general principle of the application and including the undocumented common knowledge in the art of the application
Or conventional techniques.The description and examples are only to be considered as illustrative, and the true scope and spirit of the application are by following
Claim is pointed out.
It should be understood that the application is not limited to the precise structure that has been described above and shown in the drawings, and
And various modifications and changes may be made without departing from the scope thereof.Scope of the present application is only limited by the accompanying claims.
Claims (7)
1. a kind of pumping signal processing system for brain edema monitor characterized by comprising
Control system (1), for configuring and controlling and receiving circuit (3) and transmit circuit (2)；
The transmit circuit (2), for sending pumping signal to human body head according to the instruction of the control system (1)；
The signal for receiving the signal obtained from human body head, and is sent to the control and is by the reception circuit (3)
System (1) is handled；
The transmit circuit (2) includes DDS signal generator (21) and the transmitter that connect with the DDS signal generator (21)
(22)；
The DDS signal generator (21), for generating pumping signal；
The transmitter (22), for the pumping signal to be amplified and filtered, by treated, pumping signal is electric by sending
Pole or transmit coil are sent to human body head；
The receiver for receiving circuit (3) and including differential amplifier circuit (31) and being connect with the differential amplifier circuit (31)
(32)；
The differential amplifier circuit (31), for obtain receiving electrode perhaps the signal receiving electrode of receiving coil or
Receiving coil is respectively at least one set, includes two receiving electrodes or two receiving coils in one group, and one group of reception is electric
The corresponding position in two sides that pole or one group of receiving coil are individually positioned in human body head；
The receiver (32) is used to that the signal that the differential amplifier circuit (31) export to be amplified and be filtered, and, it will handle
Signal afterwards is sent to the control system (1).
2. system according to claim 1, which is characterized in that the quantity of the sender electrode or transmit coil difference 1
It is a, the either side of human body head is set.
3. system according to claim 2, which is characterized in that the system also includes switching network, the switch
Handover network respectively with the transmit circuit (2), the reception circuit (3), the sender electrode or transmit coil and described
Receiving electrode or receiving coil connection.
4. system according to claim 1-3, which is characterized in that the pumping signal is predetermined pulse width model
Enclose the pulse signal with predetermined pulse repetition rate.
5. system according to claim 4, which is characterized in that the pulse signal is pulse, pulse train or volume
Code pulse train.
6. system according to claim 1, which is characterized in that the control system (1) include computer, microprocessor,
Digital signal processor or FPGA.
7. system according to claim 6, which is characterized in that the system also includes analog-digital converter, the modulus turns
Parallel operation is connect with the receiver (32), for converting digital signal for the analog signal that the receiver (32) export.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910295373.9A CN110022179A (en) | 2019-04-12 | 2019-04-12 | A kind of pumping signal processing system for brain edema monitor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910295373.9A CN110022179A (en) | 2019-04-12 | 2019-04-12 | A kind of pumping signal processing system for brain edema monitor |
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| CN110022179A true CN110022179A (en) | 2019-07-16 |
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| CN201910295373.9A Pending CN110022179A (en) | 2019-04-12 | 2019-04-12 | A kind of pumping signal processing system for brain edema monitor |
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| CN202875327U (en) * | 2012-02-27 | 2013-04-17 | 重庆博恩富克医疗设备有限公司 | Device for monitoring hydrocephalus and encephaledema |
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| CN107106061A (en) * | 2014-09-03 | 2017-08-29 | 脑科技医疗系统股份有限公司 | The fluid levels changed with analysis space are detected using magnetic signal |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120303001A1 (en) * | 2003-09-26 | 2012-11-29 | New York University | System and Method for Correction of Intracerebral Chemical Imbalances |
| CN102178515A (en) * | 2011-03-17 | 2011-09-14 | 何宗彦 | Hypertensive encephalopathy monitor |
| CN102579008A (en) * | 2012-02-27 | 2012-07-18 | 重庆博恩富克医疗设备有限公司 | Device and method for monitoring hydrocephalus and encephaledema |
| CN202875327U (en) * | 2012-02-27 | 2013-04-17 | 重庆博恩富克医疗设备有限公司 | Device for monitoring hydrocephalus and encephaledema |
| CN107106061A (en) * | 2014-09-03 | 2017-08-29 | 脑科技医疗系统股份有限公司 | The fluid levels changed with analysis space are detected using magnetic signal |
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Effective date of registration: 20210816 Address after: 400000 No.30, gaotanyanzheng street, Shapingba District, Chongqing Applicant after: The First Affiliated Hospital of Chinese PLA Army Medical University Applicant after: Chong Qing Born-Fuke Medical Equipment Co.,Ltd. Address before: 401120 5th floor, area 1, Jupiter science and technology building, No.9, middle section of Huangshan Avenue, gaoxinyuan, northern New District, Yubei District, Chongqing Applicant before: Chong Qing Born-Fuke Medical Equipment Co.,Ltd. |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190716 |