CN1100082C - Surface lubricating modification process of medical high molecular material - Google Patents
Surface lubricating modification process of medical high molecular material Download PDFInfo
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- CN1100082C CN1100082C CN 00112858 CN00112858A CN1100082C CN 1100082 C CN1100082 C CN 1100082C CN 00112858 CN00112858 CN 00112858 CN 00112858 A CN00112858 A CN 00112858A CN 1100082 C CN1100082 C CN 1100082C
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- hydrophilic monomer
- high molecular
- macromolecular materials
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- molecular material
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Abstract
The present invention relates to a surface lubrication and modification method for medical high molecular materials. The method is characterized in that a medical high molecular material sample is soaked in a hydrophilic monomer solution for 0.5 to 100 hours, and the concentration of a hydrophilic monomer is from 0.5 mol/L to 10 mol/L. The sample is taken out and irradiated by ultraviolet rays with the power of 10 to 500W, which leads that the surface of the medical high molecular material is grafted with the hydrophilic monomer, the irradiation is carried out for 5 to 250 minutes, and the irradiation distance is from 5 centimeters to 100 centimeters. The irradiated medical high molecular material is washed by distilled water or deionization water at 30 to 80 DEG C to remove residual homopolymers on the surface and is dried for 1 to 48 hours at 30 to 100 DEG C, and the grafting density of 0.05 to 25 mg/cm<2> is measured by a weighing method.
Description
The present invention relates to the method that UV-light causes medical macromolecular materials surface grafting hydrophilic monomer, belong to medical macromolecular materials modification field.
European patent 0521605A2 discloses the short chain polymer of and hydrophobic monomer multipolymer composition hydrophilic with UV-light grafting on fluoropolymer to improve the wetting ability and the oilness of polymer particle microsphere surface, the weak point of this patent is: 1. surface grafting reaction conditions height, graft reaction is difficult for taking place, and 2. the lubricant effect of hydrophilic, hydrophobic short chain copolymer is undesirable.United States Patent (USP) 4847324 has been reported the surface of arriving polymkeric substance with coating after the hydrophilic macromolecule blend to obtain oilness, and the shortcoming of this patent is the long-acting oilness that can not keep polymer surfaces.
The objective of the invention is to provide a kind of method of medical macromolecular materials surface lubrication modification at the deficiencies in the prior art.Be characterized in the medical macromolecular materials sample be placed in the hydrophilic monomer solution soak 0.5-100 hour after, adopt UV-irradiation to cause medical macromolecular materials surface grafting hydrophilic monomer, thereby improve its lubricity.
Purpose of the present invention is realized by following technical measures.
1. the medical macromolecular materials sample is placed in the hydrophilic monomer solution and soaked 0.5-100 hour, hydrophilic monomer concentration is 0.5-10mol/L, take out sample, adopt power to cause medical macromolecular materials surface grafting hydrophilic monomer for the 10-500W UV-irradiation, irradiation time is 5-250 minute, and irradiation distance is 5-100 centimetre.
2. postradiation medical macromolecular materials 30-80 ℃ the distilled water or the homopolymer of deionized water flush away remained on surface, in temperature 30-100 ℃ of oven dry 1-48 hour, recording grafting density with weighting method was 0.05-25mg/cm
2
Medical macromolecular materials are that polyethylene, polypropylene, polyvinyl chloride, tetrafluoroethylene, polymethylmethacrylate, polyethylene terephthalate and/or urethane are at least a.
Hydrophilic monomer is that hydroxyethyl methylacrylate, Rocryl 410, vinylformic acid, ethylene glycol, toxilic acid, vinyl pyrrolidone, DMAA and/or acrylamide are at least a.
Behind the medical macromolecular materials grafting hydrophilic monomer, its grafting density, saturated water absorption increase along with the increasing of hydrophilic monomer concentration, and water contact angle and frictional coefficient strengthen along with hydrophilic monomer concentration and reduce, detailed being shown in Table 1.
Behind the medical macromolecular materials grafting hydrophilic monomer, its grafting density increases along with the increasing of the growth of ultraviolet lighting time and monomer concentration, detailed being shown in Table 2.
The present invention has following advantage:
1. the medicine equipment that medical macromolecular materials of the present invention are made uses under wetting environment good lubricity and long-acting oilness.
2. the present invention can make that the medical macromolecular materials skin friction coefficient is minimum to reach 0.05, is enough to satisfy the clinical service requirements of medical article.To same goods, still has goodish oilness after the repeated use repeatedly.Can make some medical article be converted into repeated use, save a large amount of resources and reduce the generation of solid waste, greatly reduce manufacturing cost and use price by disposable use.
Embodiment
Below by embodiment the present invention is carried out concrete description; be necessary to be pointed out that at this following examples can only further specify the present invention with work; can not be interpreted as limiting the scope of the invention, those skilled in the art can make the improvement and the adjustment of some non-intrinsically safes according to above content.
1. polyethylene specimen surface is cleaned, be soaked in the acrylamide solution of 5mol/L 24 hours, take out, be placed under the ultraviolet lamp of 250W, secluding air irradiation 30 minutes, distance is 50 centimetres.Sample slowly rotates in the irradiation process, makes its irradiation even.Sample is taken out in the irradiation back that finishes, and with 80 ℃ of distilled water immersions 24 hours, every two hours changes water one time, fully the surperficial homopolymer of flush away.
2. the N-V-Pyrol RC aqueous solution of polyurethane samples being put into 3mol/L soaked 30 hours, took out, and was placed under the ultraviolet lamp of 350W the secluding air irradiation 50 minutes, and distance is 15 centimetres.Sample is taken out in the irradiation back that finishes, and with 80 ℃ of distilled water immersions 50 hours, every two hours changes water one time, fully the surperficial homopolymer of flush away.
3. the N,N-DMAA solution of the polyethylene terephthalate sample being put into 2mol/L soaked 50 hours, took out, and was placed under the ultraviolet lamp of 500W the secluding air irradiation 60 minutes, and distance is 35 centimetres.Sample is taken out in the irradiation back that finishes, and with 80 ℃ of distilled water immersions 20 hours, every two hours changes water one time, fully the surperficial homopolymer of flush away.
The relation of table 1 monomer concentration and relevant physical parameter
| Monomer concentration (mol/L) | Grafting density ρ (mg/cm 2) | Saturated water absorption ρ (mg/cm 2) | Water contact angle θ (°) | Coefficientoffriction |
| 0 (blank sample) | 0 | 0.70 | 78 | 0.551 |
| 3 | 2.69 | 4.48 | 52 | 0.107 |
| 4 | 3.64 | 6.17 | 46 | 0.070 |
| 5 | 4.49 | 9.06 | 39 | 0.061 |
| 6 | 4.12 | 7.07 | 42 | 0.034 |
The relation of table 2 grafting density and light application time and monomer concentration
Claims (1)
1, surface lubricating modification process of medical high molecular material is characterized in that:
(1) the medical macromolecular materials sample is placed on soaked in the hydrophilic monomer solution 0.5～100 hour, hydrophilic monomer concentration is 0.5～10mol/L, take out sample, adopting power is that 10～500W UV-irradiation causes medical macromolecular materials grafting hydrophilic monomer, irradiation time 5～250 minutes, 5～100 centimetres of irradiation distances
(2) postradiation medical macromolecular materials were dried 1～48 hour for 30～100 ℃ in temperature with 30～80 ℃ the distilled water or the homopolymer of deionized water flush away remained on surface, and recording grafting density with weighting method is 0.05～25mg/cm
2,
Wherein medical macromolecular materials are at least a in polyethylene, polypropylene, polyvinyl chloride, tetrafluoroethylene, polymethylmethacrylate, polyethylene terephthalate and/or the urethane; Hydrophilic monomer is at least a in hydroxyethyl methylacrylate, Rocryl 410, vinylformic acid, ethylene glycol, toxilic acid, vinyl pyrrolidone, DMAA and/or the acrylamide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112858 CN1100082C (en) | 2000-04-18 | 2000-04-18 | Surface lubricating modification process of medical high molecular material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00112858 CN1100082C (en) | 2000-04-18 | 2000-04-18 | Surface lubricating modification process of medical high molecular material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1318579A CN1318579A (en) | 2001-10-24 |
| CN1100082C true CN1100082C (en) | 2003-01-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00112858 Expired - Fee Related CN1100082C (en) | 2000-04-18 | 2000-04-18 | Surface lubricating modification process of medical high molecular material |
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| CN (1) | CN1100082C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296551C (en) * | 2003-09-29 | 2007-01-24 | 中国科学院上海原子核研究所 | Process for forming graft copolymer by ultraviolet light direct radiating silk |
| JP6109607B2 (en) * | 2013-03-08 | 2017-04-05 | 住友ゴム工業株式会社 | Surface modification method for three-dimensional object and gasket for syringe |
| CN105949651A (en) * | 2016-05-24 | 2016-09-21 | 重庆大学 | Polyvinyl chloride (PVC) size hydrophilic modification method |
| DE102017011956A1 (en) * | 2017-05-17 | 2018-11-22 | Phenox Gmbh | Coating for medical devices |
| CN108530665A (en) * | 2018-04-23 | 2018-09-14 | 青岛高新区尚达医药研究所 | A kind of lubrication antibacterial resin spectacle frame and preparation method thereof |
| CN110628070B (en) * | 2019-09-17 | 2022-02-08 | 北京大学第三医院（北京大学第三临床医学院） | Hydrogel-coated medical brace and preparation method and application thereof |
| CN111653689B (en) * | 2020-06-15 | 2023-04-28 | 京东方科技集团股份有限公司 | Preparation method of lens array, display device and preparation method of display device |
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2000
- 2000-04-18 CN CN 00112858 patent/CN1100082C/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN1318579A (en) | 2001-10-24 |
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