CN110003637A - A kind of medical material and preparation method thereof - Google Patents
A kind of medical material and preparation method thereof Download PDFInfo
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- CN110003637A CN110003637A CN201910293812.2A CN201910293812A CN110003637A CN 110003637 A CN110003637 A CN 110003637A CN 201910293812 A CN201910293812 A CN 201910293812A CN 110003637 A CN110003637 A CN 110003637A
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- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/22—Compounding polymers with additives, e.g. colouring using masterbatch techniques
- C08J3/226—Compounding polymers with additives, e.g. colouring using masterbatch techniques using a polymer as a carrier
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- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/04—Homopolymers or copolymers of ethene
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- C08J2353/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2353/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2353/02—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
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- C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
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- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2423/04—Homopolymers or copolymers of ethene
- C08J2423/08—Copolymers of ethene
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2453/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
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- C08J2453/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
- C08J2453/02—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers of vinyl aromatic monomers and conjugated dienes
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2471/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
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- C08J2475/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2475/04—Polyurethanes
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- C08J2491/00—Characterised by the use of oils, fats or waxes; Derivatives thereof
- C08J2491/06—Waxes
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
- C08K2003/0887—Tungsten
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- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/30—Sulfur-, selenium- or tellurium-containing compounds
- C08K2003/3045—Sulfates
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- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/24—Acids; Salts thereof
- C08K3/26—Carbonates; Bicarbonates
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- Polymers & Plastics (AREA)
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- Processes Of Treating Macromolecular Substances (AREA)
- Extrusion Moulding Of Plastics Or The Like (AREA)
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Abstract
The invention discloses a kind of medical material and preparation method thereof, the preparation method includes the following steps: S1: thermoplastic elastomer (TPE) being passed through extrusion granulation, obtains thermoplastic elastomer (TPE) particle；S2: the thermoplastic elastomer (TPE) particle and filler blending extrusion that the step S1 is obtained obtain filler master batch；S3: the filler master batch and color masterbatch particle blending extrusion that the obtained thermoplastic elastomer (TPE) particle of the step S1 and the step S2 are obtained obtain medical material；S4: adding lubricant in the blending and modifying particle that the step S3 is obtained, and by blending extrusion, obtains the medical material that pellet melting index is 20-50g/min.Preparation method provided by the invention solves the thermoplastic elastic material of high-hard section ratio bad dispersibility, easily foaming and the problems such as poor fluidity in process.Prepared medical material may be used on the products such as electro physiology radio frequency ablation catheter and mapping catheter.
Description
Technical field
The present invention relates to a kind of bio-medical raw material and preparation method thereof more particularly to a kind of thermoplastic elastomer (TPE) are medical
Material and preparation method thereof.
Background technique
It is that medicine covers painstaking effort to one of the significant contribution of human civilization at the end of the 20th century that Micro trauma, which intervenes medical technology,
The science and technology such as pipe, the cerebrovascular, main artery, periphery, electro physiology.Micro-dimension medical tube is the key that Micro trauma interventional medical device
Material, requirement of the Micro trauma interventional medical device to micro-dimension medical tube is very high, and technical difficulty is big, always by American-European institute, company
Monopolization.In the past 20 years, the main difficult technical of China's Micro trauma interventional medical device micro-dimension medical tube industrialization includes medical
Synthesis of polymer material, medical macromolecular materials modification, micro- extrusion, welding, grinding, braiding, spring, condensed state structure regulation etc.
Key technology and key equipment.
There is good compatibility and heat fusing between the medical macromolecular materials of identical series different hardness, for minimally invasive
When hurting interventional medical device, the different piece for selecting different materials to make conduit can according to need, to obtain hardness gradient
Conduit.Because Micro trauma interventional medical device conduit and conveyer are usually all long, leading portion requires softness, to pass through people
The curved blood vessel of body reaches lesion；And back segment requires have certain degree of hardness, just can guarantee there is foot during conduit enters human body
Enough support forces.
Thermoplastic elastomer (TPE) is a kind of thermoplastic multi-block copolymer, due to its good biocompatibility, good
Anticoagulant property and good toughness and elasticity, make it have a wide range of applications in field of biomedicine.Existing thermoplastic elastomehc
Property body have the defects that in aspect of performance it is certain, such as high-hard section ratio thermoplastic elastomer (TPE) addition barium sulfate, waltherite,
When tungsten powder etc. is as developer, but these fillers are in the thermoplastic elastomer (TPE) for being added to high-hard section ratio, processed
The duration is short (< 1h) in journey, there are bad dispersibility, easily foams (bubble is more) and the problems such as poor fluidity, seriously affects
The processing of later product.Therefore, it is necessary to the thermoplastic elastomer blending materials to existing high-hard section ratio to be modified.
Summary of the invention
The technical problem to be solved by the present invention is to thermoplastic elastomer (TPE)s when adding filler blending developing material, this is filled out
It fills object and developing material bad dispersibility, easily foaming and poor fluidity in process is blended.
The present invention to solve above-mentioned technical problem and the technical solution adopted is that provide a kind of preparation method of medical material,
Include the following steps: S1: by thermoplastic elastomer (TPE) by extrusion granulation, obtaining thermoplastic elastomer (TPE) particle；S2: by the step
The thermoplastic elastomer (TPE) particle and filler blending extrusion that S1 is obtained, obtain filler master batch；S3: the step S1 is obtained
The filler master batch and color masterbatch particle blending extrusion that thermoplastic elastomer (TPE) particle and the step S2 are obtained, obtain blending and modifying grain
Son；S4: adding lubricant in the blending and modifying particle that the step S3 is obtained, and by blending extrusion, obtains pellet melting and refers to
Number is the medical material of 20-50g/10min.
Preferably, the step S1 includes: by the thermoplastic elastomer (TPE) by twin-screw blending extrusion machine, and extrusion obtains
Cylindrical thermoplastic elastomer (TPE) particle.
Preferably, in the step S1, the thermoplastic elastomer (TPE) is polyether block amide, thermoplastic polyurethane elastic
At least one of body, styrene block copolymer, Styrene-Butadiene-Styrene Block Copolymer or octene copolymer.
Preferably, in the step S2, the filler is at least one of barium sulfate, waltherite or tungsten powder.
Preferably, in the step S2, the quality of the thermoplastic elastomer (TPE) particle is the filler master batch quality
40%~70%, the thermoplastic elastomer (TPE) particle and the filler squeeze out to obtain the filling through twin-screw blending extrusion machine
Object master batch.
Preferably, in the step S3, the thermoplastic elastomer (TPE) mass particle is the blending and modifying mass particle
10%~40%, the filler master batch quality is the 20%-59% of the blending and modifying mass particle, the thermoplastic elastic
Body particle, the filler master batch and the color masterbatch particle pass through after mixing evenly twin-screw blending extrusion machine squeeze out to obtain it is described
Blending and modifying particle.
Preferably, the lubricant quality added in the step S4 is the 2%-10% of the blending and modifying mass particle.
Preferably, the twin-screw blending extrusion machine set temperature be 180-240 DEG C, screw speed be 400-1200 turn/
Minute.
Preferably, lubricant described in the step S4 is at least one of white oil, stearic amide or paraffin powder.
Another technical solution that the present invention uses to solve above-mentioned technical problem is to provide a kind of medical material, by above-mentioned
Preparation method is produced.
The present invention compare the prior art have it is following the utility model has the advantages that medical material provided by the invention and preparation method thereof,
Thermoplastic elastomer (TPE), using being blended after addition lubricant, effectively improves filler when adding filler blending developing material
The blend uniformity and mobility of developing material is blended, it is easy to stick in process to solve filler blending developing material material
The problems such as mould, agglomeration, bad dispersibility, easy foaming and poor fluidity, and this process implementing is simple, it is low in cost, it is easy to criticize
Quantization production.Prepared medical material may be used on the products such as electro physiology radio frequency ablation catheter and mapping catheter.
Specific embodiment
The present invention will be further described with reference to the examples below.
Embodiment 1
Firstly, the thermoplastic elastomer (TPE) of predetermined amount is passed through twin-screw blending extrusion machine, its internal crafters is removed, is squeezed
It is granulated out, obtains cylindrical thermoplastic elastomer (TPE) particle.The twin-screw blending extrusion machine may include multistage temperature, and each section
Temperature range can be same or different.In the present embodiment, each section of temperature range is different, but each section of temperature range
It is set in 180-240 DEG C of section.The screw speed of the twin-screw blending extrusion machine is set as 500 revs/min.Specifically
Ground, the thermoplastic elastomer (TPE) can be the thermoplastic elastomer (TPE) of high-hard section ratio, such as can be polyether block amide
(PEBA), thermoplastic polyurethane elastomer (TPU), styrene block copolymer (SBC), s-B-S block
The materials such as copolymer (SBS) or octene copolymer (POE).In the present invention, thermoplastic elastomer (TPE) can be by soft segment and hard section structure
At definition of the hard section ratio greater than or equal to 90% is the thermoplastic elastomer (TPE) of high-hard section ratio.
Then, obtained thermoplastic elastomer (TPE) particle is blended according to a certain percentage with filler, is blended and squeezes through twin-screw
Machine squeezes out the filler master batch being blended out.In the present embodiment, the filler can be developing material, such as can be
At least one of barium sulfate, waltherite or tungsten powder etc..The quality of the thermoplastic elastomer (TPE) particle is the filler master batch
The 40%~70% of quality.In 180-240 DEG C of section, screw rod turns the set temperature of each section of the twin-screw blending extrusion machine
Speed is 400-1200 revs/min.
Then, thermoplastic elastomer (TPE) particle, filler master batch and color masterbatch particle are stirred evenly according to predetermined ratio, is passed through
Twin-screw blending extrusion machine squeezes out, and obtains the blending and modifying particle of corresponding color.The thermoplastic elastomer (TPE) mass particle can be with
It is the 10%~40% of the blending and modifying mass particle, the filler master batch quality can be the blending and modifying particle matter
The 20%-59% of amount.
Finally, adding lubricant in obtained blending and modifying particle, the lubricant quality of addition is blending and modifying particle
The 2% of quality, lubricant can be at least one of white oil, stearic amide, paraffin powder etc., and twin-screw blending extrusion machine is set
Fixed temperature is 180~220 DEG C, and 400~1200 revs/min of screw speed, the pellet melting index being blended is 20-50g/
min.Addition lubricant effect be reduce material between and material and process equipment surface frictional force, to reduce melt
Flow resistance reduces melt viscosity, improves the mobility of melt, avoid the adherency of melt and equipment, improve the light of product surface
Slippery.A kind of numerical value of mobility when melt index is expression plastic material processing.Its test method is first plastic pellet to be allowed to exist
In certain time (10 minutes), under certain temperature and pressure, it is melted into plastic liquid, is then 2.095mm circle by a diameter
Gram (g) number that pipe is flowed out.Its value is bigger, indicates that the processing fluidity of the plastic material is better, on the contrary then poorer.Melt index
The viscosity flow characteristic of thermoplastic in the molten state can be characterized, to the quality for guaranteeing thermoplastic and its product, to adjustment
Production technology has important directive significance.
Embodiment 2
The present embodiment is identical as the product structure of embodiment 1 and production technology, and difference is the ratio of the lubricant added
Example is different, and the lubricant quality of addition is the 5% of blending and modifying mass particle, and the pellet melting index being blended is 22g/
10min~29g/10min.
Embodiment 3
The present embodiment is identical as the product structure of embodiment 1 and production technology, and difference is the ratio of the lubricant added
Example is different, and the lubricant quality of addition is the 8% of blending and modifying mass particle, and the pellet melting index being blended is 35g/
10min~39g/10min.
Embodiment 4
The present embodiment is identical as the product structure of embodiment 1 and production technology, and difference is the ratio of the lubricant added
Example is different, and the lubricant quality of addition is the 10% of blending and modifying mass particle, and the pellet melting index for being blended out is 43g/
10min~48g/10min.
To sum up, the preparation method of medical material provided by the invention has the advantage that
A) thermoplastic elastomer (TPE) of high-hard section ratio is solved by way of blending in addition barium sulfate, waltherite, tungsten
When developing material is blended in the fillers such as powder, bad dispersibility in process, the problem of easily foaming.
B) using being blended after adding a kind of lubricant, the blending for effectively improving the thermoplastic elastomer (TPE) of high-hard section ratio is equal
Even property and mobility solve the material the process poor fluidity the problems such as.
C) method preparation process provided by the invention is simple, can carry out successional large-scale production.By to double spiral shells
The regulation of bar blending extrusion machine temperature, screw speed and lubricant ratio can reach molten to material particles after blending and modifying
Melt the control of index.
Although the present invention is disclosed as above with preferred embodiment, however, it is not to limit the invention, any this field skill
Art personnel, without departing from the spirit and scope of the present invention, when can make a little modification and perfect therefore of the invention protection model
It encloses to work as and subject to the definition of the claims.
Claims (10)
1. a kind of preparation method of medical material, which comprises the steps of:
S1: thermoplastic elastomer (TPE) is passed through into extrusion granulation, obtains thermoplastic elastomer (TPE) particle；
S2: the thermoplastic elastomer (TPE) particle and filler blending extrusion that the step S1 is obtained obtain filler master batch；
S3: the filler master batch and Masterbatch that the obtained thermoplastic elastomer (TPE) particle of the step S1 and the step S2 are obtained
Sub- blending extrusion obtains blending and modifying particle；
S4: adding lubricant in the blending and modifying particle that the step S3 is obtained, and by blending extrusion, obtains pellet melting and refers to
Number is the medical material of 20-50g/10min.
2. the preparation method of medical material as described in claim 1, which is characterized in that the step S1 includes: by the heat
Thermoplastic elastic passes through twin-screw blending extrusion machine, and extrusion obtains cylindrical thermoplastic elastomer (TPE) particle.
3. the preparation method of medical material as described in claim 1, which is characterized in that the thermoplastic elastomer (TPE) is that polyethers is embedding
Section amide, thermoplastic polyurethane elastomer, styrene block copolymer, Styrene-Butadiene-Styrene Block Copolymer or pungent
At least one of alkene copolymer.
4. the preparation method of medical material as described in claim 1, which is characterized in that in the step S2, the filler
For at least one of barium sulfate, waltherite or tungsten powder.
5. the preparation method of medical material as described in claim 1, which is characterized in that in the step S2, the thermoplasticity
The quality of elastomer particle is the 40%~70% of the filler master batch quality, and the thermoplastic elastomer (TPE) particle is filled out with described
Object is filled to squeeze out to obtain the filler master batch by twin-screw blending extrusion machine.
6. the preparation method of medical material as described in claim 1, which is characterized in that in the step S3, the thermoplasticity
Elastomer particle quality is the 10%~40% of the blending and modifying mass particle, and the filler master batch quality is the blending
The 20%-59% of modified particle quality, the thermoplastic elastomer (TPE) particle, the filler master batch and the color masterbatch particle stir
It squeezes out to obtain the blending and modifying particle by twin-screw blending extrusion machine after uniformly.
7. the preparation method of medical material as described in claim 1, which is characterized in that the lubricant added in the step S4
Quality is the 2%-10% of the blending and modifying mass particle.
8. the preparation method of the medical material as described in claim 2,5 or 6, which is characterized in that the twin-screw blending extrusion
Machine set temperature is 180-240 DEG C, and screw speed is 400-1200 revs/min.
9. the preparation method of medical material as described in claim 1, which is characterized in that lubricant described in the step S4 is
At least one of white oil, stearic amide or paraffin powder.
10. a kind of medical material, which is characterized in that the medical material is by the described in any item preparation methods of claim 1-9
It produces.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910293812.2A CN110003637A (en) | 2019-04-12 | 2019-04-12 | A kind of medical material and preparation method thereof |
| PCT/CN2020/082925 WO2020207320A1 (en) | 2019-04-12 | 2020-04-02 | Medical material and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910293812.2A CN110003637A (en) | 2019-04-12 | 2019-04-12 | A kind of medical material and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111040429A (en) * | 2019-12-30 | 2020-04-21 | 脉通医疗科技(嘉兴)有限公司 | Medical tube and preparation method thereof |
| WO2020207320A1 (en) * | 2019-04-12 | 2020-10-15 | 脉通医疗科技(嘉兴)有限公司 | Medical material and preparation method thereof |
| CN111939328A (en) * | 2020-08-18 | 2020-11-17 | 西安乐析医疗科技有限公司 | Novel peritoneal dialysis tube and manufacturing method thereof |
| CN113861379A (en) * | 2020-06-30 | 2021-12-31 | 三元科技（深圳）有限公司 | Manufacturing method of TPU (thermoplastic polyurethane) medical cable and medical cable |
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| CN104861303A (en) * | 2015-06-12 | 2015-08-26 | 福路明精密管材（北京）有限公司 | Medical polypropylene composite material and preparation method thereof |
| CN105727375A (en) * | 2016-02-02 | 2016-07-06 | 乐普（北京）医疗器械股份有限公司 | Nylon blend and preparation method and application thereof |
| CN108276638A (en) * | 2017-12-29 | 2018-07-13 | 深圳职业技术学院 | A kind of tubing and preparation method thereof with X-ray developing function |
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| CN102010547A (en) * | 2010-12-23 | 2011-04-13 | 南京聚隆科技股份有限公司 | Mineral/long glass fiber reinforced polypropylene composite material and preparation method thereof |
| CN106215195B (en) * | 2016-07-27 | 2019-09-17 | 上海安翰医疗技术有限公司 | Digestive tract power detects capsule and preparation method thereof |
| CN110003637A (en) * | 2019-04-12 | 2019-07-12 | 脉通医疗科技(嘉兴)有限公司 | A kind of medical material and preparation method thereof |
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- 2019-04-12 CN CN201910293812.2A patent/CN110003637A/en active Pending
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| CN104861303A (en) * | 2015-06-12 | 2015-08-26 | 福路明精密管材（北京）有限公司 | Medical polypropylene composite material and preparation method thereof |
| CN105727375A (en) * | 2016-02-02 | 2016-07-06 | 乐普（北京）医疗器械股份有限公司 | Nylon blend and preparation method and application thereof |
| CN108276638A (en) * | 2017-12-29 | 2018-07-13 | 深圳职业技术学院 | A kind of tubing and preparation method thereof with X-ray developing function |
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| WO2020207320A1 (en) * | 2019-04-12 | 2020-10-15 | 脉通医疗科技(嘉兴)有限公司 | Medical material and preparation method thereof |
| CN111040429A (en) * | 2019-12-30 | 2020-04-21 | 脉通医疗科技(嘉兴)有限公司 | Medical tube and preparation method thereof |
| CN111040429B (en) * | 2019-12-30 | 2021-12-24 | 脉通医疗科技(嘉兴)有限公司 | Medical tube and preparation method thereof |
| CN113861379A (en) * | 2020-06-30 | 2021-12-31 | 三元科技（深圳）有限公司 | Manufacturing method of TPU (thermoplastic polyurethane) medical cable and medical cable |
| CN111939328A (en) * | 2020-08-18 | 2020-11-17 | 西安乐析医疗科技有限公司 | Novel peritoneal dialysis tube and manufacturing method thereof |
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