CN109997193A - 一种对特定群中的亚群进行定量分析的方法 - Google Patents

一种对特定群中的亚群进行定量分析的方法 Download PDF

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CN109997193A
CN109997193A CN201680090780.0A CN201680090780A CN109997193A CN 109997193 A CN109997193 A CN 109997193A CN 201680090780 A CN201680090780 A CN 201680090780A CN 109997193 A CN109997193 A CN 109997193A
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frequency
snp
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CN109997193B (zh
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彭也
李俊桦
唐珊媚
张慧
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BGI Shenzhen Co Ltd
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Abstract

一种对特定群中的亚群进行定量分析的方法。具体地，包括以下步骤：(1)提供对应于所述特定群的(a)参考基因组序列数据、(b)参考SNP矩阵和(c)宏基因组测序数据；(2)将所述宏基因组测序数据比对到对应于所述特定群的参考基因组数据上，以便获得比对结果；(3)根据所述参考SNP矩阵的位点信息，构建频率矩阵；(4)根据频率矩阵对参考SNP矩阵做二值化处理，得到二值化SNP矩阵；和(5)基于所述的频率矩阵、所述的二值化SNP矩阵、理论碱基频率向量f(x)和观测碱基频率向量y，通过有约束的线性模型，得出所述特定群中各亚群的相对丰度，从而获得对所述特定群中的亚群的定量分析结果。

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PCT国内申请，说明书已公开。

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  1. PCT国内申请，权利要求书已公开。
CN201680090780.0A 2016-11-10 2016-11-10 一种对特定群中的亚群进行定量分析的方法 Active CN109997193B (zh)

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CN112786102B (zh) * 2021-01-25 2022-10-21 北京大学 一种基于宏基因组学分析精准识别水体中未知微生物群落的方法
CN114300055B (zh) * 2021-12-28 2023-04-25 江苏先声医学诊断有限公司 优化的宏基因组纳米孔测序数据定量方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112151120A (zh) * 2020-09-23 2020-12-29 易会广 用于快速转录组表达定量的数据处理方法、装置及存储介质
CN112151120B (zh) * 2020-09-23 2024-03-12 易会广 用于快速转录组表达定量的数据处理方法、装置及存储介质

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