CN1099871C - Shuanggan injection and preparation process thereof - Google Patents
Shuanggan injection and preparation process thereof Download PDFInfo
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- CN1099871C CN1099871C CN 99125517 CN99125517A CN1099871C CN 1099871 C CN1099871 C CN 1099871C CN 99125517 CN99125517 CN 99125517 CN 99125517 A CN99125517 A CN 99125517A CN 1099871 C CN1099871 C CN 1099871C
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- injection
- water
- mannitol
- glycerol
- shuanggan
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a Shuanggan injection which comprises mannitol, glycerol, fructose 1, 6-diphosphate and water for injection. When the present invention is prepared, an operating course comprises the following steps: A: the mannitol is taken, a small part of the water for injection is added and is heated to dissolve the mannitol, and the glycerol is added and is used when the glycerol is uniformly stirred; B: the fructose 1 and the 6-diphosphate is taken, a small part of the water for injection is added, and a pH value is adjusted to 3.0 to 5.0 by hydrochloric acid; and mixtures prepared by step A and step B are mixed, residual water for injection is added to carry out dilution, and filling, mouth sealing and sterilization are carried out. The Shuanggan injection can be used for the depressurization treatment of high intracranial pressure patients of a neurological department and a neurosurgical department and has the characteristics of rapid administration, long actuation duration, etc. and can decrease side effects.
Description
The present invention relates to medical preparation, particularly a kind of Shuanggan injection and preparation method thereof.
The prescription of the dehydration and diuresis medicine that present China pharmacopeia is recorded has: sorbitol, mannitol and carbamide, clinical main application formula mannitol injection liquid, widely apply mannitol can cause serious adverse reaction, as: hematuria, acute renal failure, electrolyte disturbance, low intracranial pressure etc.Triglyceride compound injection listing is arranged again in recent years, and its advantage is an action temperature and and lasting, but the too fast easy generation haemolysis that instils has limited the application of critical patient.
The purpose of this invention is to provide a kind ofly can give fast, acting duration is long, can reduce the Shuanggan injection of side effect again.
Another object of the present invention provides a kind of preparation method of above-mentioned Shuanggan injection.
Contain mannitol, glycerol, 1 in the Shuanggan injection of the present invention, 6-fructose diphosphate and water for injection; Wherein, the parts by weight proportioning of described each composition is:
Mannitol 10-20 part
Glycerol 5-15 part
1,6-fructose diphosphate 2-10 part
100 parts of waters for injection
The preparation method of Shuanggan injection of the present invention may further comprise the steps:
A: get mannitol and add small part water for injection, heating makes its dissolving, adds glycerol again, and it is stand-by to stir;
B: get 1, the 6-fructose diphosphate adds small part water for injection, uses the hydrochloric acid adjust pH to 3.0-5.0;
Mix A, B, add residue water for injection and dilute, add the needle-use activated carbon decolouring of solution 0.2% (g/ml) again, filter the back filling and sealing, sterilize down in 115 ℃ got final product in 30 minutes.
Shuanggan injection of the present invention is by mannitol, glycerol, 1,6-fructose diphosphate and water are formed, and are the diuresis dehydrants, can be used for Neurology Department, the high intracranial pressure patient's of neurosurgery blood pressure lowering treatment, have fast give, acting duration is long, can reduce characteristics such as side effect again.Zoopery and clinical practice show that the Shuanggan injection diuretic effect is definite, and side effect is more satisfactory dehydration and diuresis medicine for a short time.
Wherein, the pharmacological action of described three kinds of compositions is collaborative mutually: the mannitol dehydration is rapid-action, can instil fast, and the fast infusion for glycerol provides height to ooze environment simultaneously, and can prevent the generation of haemolysis; Dehydrating glycerin effect onset is slow, but long action time plays the effect of consolidating and keeping curative effect; 1, the 6-fructose diphosphate is human inner cell's metabolic intermediate, can directly stimulate pyruvate kinase, generation is Duoed one times ATP than commensurability glucose zymolysis, the energy metabolisms of important organ when anoxia such as improvement and recovery heart, brain, kidney, for the metabolism of body and glycerol provides energy, can stop on the histology extremely of ischemia institute simultaneously and the injury of kidney on the function, prevent the infringement of mannitol to kidney.
Further describe the present invention below in conjunction with embodiment.
Embodiment
A kind of Shuanggan injection, it contains mannitol, glycerol, 1,6-fructose diphosphate and water for injection; Wherein, the parts by weight proportioning of described each composition is:
Mannitol 15g
Glycerol 10g
1,6-fructose diphosphate 5g
Water for injection adds 100ml
During preparation, get mannitol earlier and add small part water for injection, heating makes its dissolving, adds glycerol again, and stirring, it is stand-by to obtain A; Get 1, the 6-fructose diphosphate adds small part water for injection, obtains B with 10% hydrochloric acid adjust pH to 4.5; Mix A, B, add residue water for injection and dilute, add the needle-use activated carbon decolouring of 2% (g/ml) again in solution, filter the back filling and sealing, sterilize down in 115 ℃ got final product in 30 minutes.
Claims (3)
1, a kind of Shuanggan injection is characterized in that containing mannitol, glycerol, 1,6-fructose diphosphate and water for injection; Wherein, the parts by weight proportioning of described each composition is:
Mannitol 10-20 part
Glycerol 5-15 part
1,6-fructose diphosphate 2-10 part
100 parts of waters for injection
2, Shuanggan injection as claimed in claim 1 is characterized in that the parts by weight proportioning of described each composition is:
Mannitol 15g
Glycerol 10g
1,6-fructose diphosphate 5g
Water for injection adds to 100ml.
3,, it is characterized in that may further comprise the steps as the preparation method of the described Shuanggan injection of claim 1-2:
A: get mannitol and add small part water for injection, heating makes its dissolving, adds glycerol again, and it is stand-by to stir;
B: get 1, the 6-fructose diphosphate adds small part water for injection, uses the hydrochloric acid adjust pH to 3.0-5.0;
Mix A, B, add residue water for injection and dilute, add the needle-use activated carbon decolouring of 0.2% (g/ml) again in solution, filter the back filling and sealing, sterilize down in 115 ℃ got final product in 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99125517 CN1099871C (en) | 1999-12-03 | 1999-12-03 | Shuanggan injection and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99125517 CN1099871C (en) | 1999-12-03 | 1999-12-03 | Shuanggan injection and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1256919A CN1256919A (en) | 2000-06-21 |
| CN1099871C true CN1099871C (en) | 2003-01-29 |
Family
ID=5283983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99125517 Expired - Fee Related CN1099871C (en) | 1999-12-03 | 1999-12-03 | Shuanggan injection and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1099871C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101732287B (en) * | 2009-12-23 | 2012-05-30 | 北京圣方达隆医药科技发展有限责任公司 | Injection of mannite and glycerol and preparation method thereof |
| CN102488696A (en) * | 2011-12-30 | 2012-06-13 | 南京正大天晴制药有限公司 | Glycerin-fructose composition injection and its preparation method |
-
1999
- 1999-12-03 CN CN 99125517 patent/CN1099871C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1256919A (en) | 2000-06-21 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |