CN109966268A - A kind of preparation method of ibuprofen sustained release capsules - Google Patents
A kind of preparation method of ibuprofen sustained release capsules Download PDFInfo
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- CN109966268A CN109966268A CN201910270735.9A CN201910270735A CN109966268A CN 109966268 A CN109966268 A CN 109966268A CN 201910270735 A CN201910270735 A CN 201910270735A CN 109966268 A CN109966268 A CN 109966268A
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- release capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
The present invention relates to technical field of medicine, in particular to a kind of preparation method of ibuprofen sustained release capsules.The preparation method includes the following steps: to wrap up lubricant solution in blank capsule core, dry, and obtains the piller of load lubricant；Binder solution is wrapped up on the piller of load lubricant, then the brufen of wrapping portion formula ratio, dries；Wrap up binder solution envelope ball twice, dry, sieving obtains the pill of loading section brufen；Binder solution is wrapped up on the pill of loading section brufen, is then wrapped up the brufen of remaining formula ratio, is dried；Wrap up binder solution envelope ball twice, dry, sieving is packed into capsule shells, obtains ibuprofen sustained release capsules.Ibuprofen sustained release capsules vitro release prepared by the present invention and original grind that product is consistent, and dissolution similarity is higher, it was demonstrated that the ibuprofen sustained release capsules of method preparation with former to grind a possibility that a possibility that release conditions of product in vivo are consistent is higher, and curative effect is consistent higher.
Description
Technical field
The present invention relates to technical field of medicine, in particular to a kind of preparation method of ibuprofen sustained release capsules.
Background technique
Ibuprofen sustained release capsules are a kind of chemical drug preparations, and indication is for alleviating mild to moderate pain such as headache, joint
Bitterly, migraine, toothache, courbature, neuralgia, dysmenorrhea.It is also used for fever caused by common cold or influenza.At present
The drug possesses 23 approval numbers of the drug in domestic drug.
Drug quality and curative effect one are ground to the imitation medicine for having been approved by listing, by with original by national requirements pharmaceutical producing enterprise
The principle of cause, imitation medicine carry out quality conformance evaluation, carry out production technology improvement not up to standard, to improve drug quality
And curative effect, benefit common people.Therefore, in order to benefit common people and comply with national requirements, a kind of production technology is studied to prepare
It is very urgent with the consistent ibuprofen sustained release capsules of curative effect with its original to grind product quality for one kind out.
The Chinese patent application of 107184565 B of publication No. CN discloses a kind of preparation method of ibuprofen sustained release capsules
Mesoporous particles are coated using organic polymer auxiliary material and are obtained.The Chinese patent application of 102114011 A of publication No. CN is public
A kind of sustained release preparations of ibuprofen is opened, preparation method includes: 1. to prepare load pill core: the blank capsule core of recipe quantity being taken to set packet
In clothing pot, lubricant solution is sprayed in blank capsule core；2. lamination method is added medicine to: successively spray adhesive solution, hydrojet interval
Phase and the brufen being added after micronization, are adhered to capsule core surface to brufen and repeat the above process, until adding brufen complete
Finish, equipment continues to run 5~15 minutes；3. it is 8~15 hours dry in 35 DEG C to take out obtained pellet；4. being filled out after intermediate detection
It is encapsulated, it packs to obtain the final product.
But the drug loading of above-mentioned sustained release preparation is lower, and production cost is higher, and rate of release is very fast, dissolution curve with
Original grinds that product differentiation is larger, cannot achieve the consistency investigated with the former release in vitro for grinding product.
Summary of the invention
In view of this, the present invention provides a kind of preparation methods of ibuprofen sustained release capsules.Brufen prepared by the present invention
It is consistent that spansule vitro release with original grinds product.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of preparation methods of ibuprofen sustained release capsules, include the following steps:
Step A: wrapping up lubricant solution in blank capsule core, dries, and obtains the piller of load lubricant；
Step B: wrapping up binder solution on the piller of load lubricant, then the brufen of wrapping portion formula ratio,
It dries；Wrap up binder solution envelope ball twice, dry, sieving obtains the pill of loading section brufen；
Step C: wrapping up binder solution on the pill of loading section brufen, then wraps up the cloth of remaining formula ratio
Ibuprofen dries；Wrap up binder solution envelope ball twice, dry, sieving is packed into capsule shells, obtains ibuprofen sustained release capsules.
It is higher that the ibuprofen sustained release capsules prepared by this patent preparation method and original grind product dissolution similarity, uses
When similar factors (f2) method compares dissolution curve similitude, similar factors (f2) numerical value is not less than 60, presses " normal oral solid
Preparation dissolution curve measurement guideline compared with " it is believed that dissolution curve is similar.Prove the ibuprofen slow-release glue of method preparation
To grind a possibility that a possibility that release conditions of product in vivo are consistent is higher, and curative effect is consistent higher with original for capsule.
Preferably, the lubricant solution is to contain the stearic ethanol solution of 3wt%~8wt%.
Preferably, lubricant solution is to contain the stearic ethanol solution of 5wt%.
Preferably, described adhesive solution is the ethanol solution containing 3wt%~8wt% povidone.
Preferably, binder solution is the ethanol solution containing 5wt% povidone.
Preferably, the blank capsule core is cane sugar core.
Preferably, the formula ratio ratio of the blank capsule core, lubricant, adhesive, brufen is (100~500):
(0.2~0.6): (10~50): (800~1200).
In specific embodiment provided by the invention, the formula ratio ratio of blank capsule core, lubricant, adhesive, brufen
For 300:0.4:30:1000.
Preferably, the pot body revolving speed when package is 20~80Hz, spray gun pressure is 0.20~0.80MPa.
Preferably, pot body revolving speed when package is 65Hz, spray gun pressure 0.5MPa.
Preferably, the temperature of the drying is 25~45 DEG C, the time is 10~15h.
Preferably, dry temperature is 35 DEG C, time 13h.
Preferably, dry is that hot air circulation is dry.
Preferably, the sieving was 12 mesh~18 meshes.
Preferably, it is sieved as 12 mesh and 18 mesh sieve are sieved excessively respectively.
Preferably, in stepb, the brufen of part formulation amount is the Bu Luo for being equivalent to formula total amount 1/4 to 1/2
It is fragrant.
Preferably, in stepb, the brufen of part formulation amount is the brufen for being equivalent to formula total amount 1/3.
Preferably, in stepb, in the brufen of part formulation amount, each injecting time 1.0 of the powder of early period 20%
~3.0min, each 2.0~4.0min of injecting time of the powder in later period 80%.
Preferably, in stepb, in the brufen of part formulation amount, each injecting time of the powder of early period 20%
1.6min, each injecting time 2.5min of the powder in later period 80%.
Preferably, step C specifically: be divided into two parts the pill of loading section brufen, then package is remaining respectively
The brufen of formula ratio, dries；Wrap up binder solution envelope ball twice, dry, sieving merges two parts of pills, is packed into capsule
Shell obtains ibuprofen sustained release capsules.
Preferably, in step C, the pill of loading section brufen is divided into two parts, equivalent residue is wrapped up respectively and matches
The brufen just measured；Do not divide equally, then by the brufen of allocation proportion package equivalent residue formula ratio, so that the drugloading rate of pill
Unanimously.
Preferably, drying in each step to rotate naturally dry with pot body, the time is 3~8min.
Preferably, capsule shells are No. 0 capsule shells.
In specific embodiment provided by the invention, liquid is sprayed into sugar-coat using spray gun by package operation in each step
It is wrapped up in pot.
The present invention provides a kind of preparation methods of ibuprofen sustained release capsules.The preparation method includes the following steps: step
A: wrapping up lubricant solution in blank capsule core, dries, and obtains the piller of load lubricant；Step B: in load lubricant
Binder solution is wrapped up on piller, then the brufen of wrapping portion formula ratio, dries；Wrap up binder solution envelope ball twice,
Dry, sieving obtains the pill of loading section brufen；Step C: adhesive is wrapped up on the pill of loading section brufen
Then solution wraps up the brufen of remaining formula ratio, dries；Wrap up binder solution envelope ball twice, dry, sieving is packed into glue
Softgel shell obtains ibuprofen sustained release capsules.The technical effect that the present invention has are as follows:
1, ibuprofen sustained release capsules piller prepared by the present invention is evenly distributed, morphological appearance, is conducive to improve patient's medication
Compliance.
2, ibuprofen sustained release capsules vitro release prepared by the present invention and original grind that product is consistent, and dissolution similarity is higher,
Prove the ibuprofen sustained release capsules of method preparation and former higher, curative effect of grinding a possibility that release conditions of product in vivo are consistent
A possibility that consistent, is higher.
Detailed description of the invention
Fig. 1 shows accumulation of the ibuprofen sustained release capsules of the present invention (000223-26) from reference preparation in different pH value media
Release；1-1 to 1-3 is respectively Accumulation dissolution of two preparations in pH6.8, pH6.0, pH5.5 medium.
Specific embodiment
The invention discloses a kind of preparation method of ibuprofen sustained release capsules, those skilled in the art can be used for reference herein
Content is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to art technology
It is it will be apparent that they are considered as being included in the present invention for personnel.Method and application of the invention has passed through preferably
Embodiment is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to side as described herein
Method and application are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.
In specifically embodiment, the preparation method of ibuprofen sustained release capsules includes the following steps:
1) 3~8wt% povidone-ethanol solution, 3~8wt% stearic acid-ethanol solution are prepared；
2) cane sugar core is added into equipment, starting device reaches optimal flow state, by 3~8wt% tristearin
Acid-ethanol solution is disposably continuously sprayed by spray gun, obtains the piller of load lubricant.
3) continue 3~8wt% of penetrating povidone-ethanol solution, after piller liquid is uniform, be sprinkled into what part had been sieved
Brufen dries 3-8min with pot body rotation.After beating powder, adhesive envelope ball is sprayed into twice, sealing ball every time must be with pot body
It rotates while being stirred continuously to naturally dry, obtain the pill of loading section brufen, the dry 10~15h of hot air circulation crosses 12
Mesh~18 meshes.
4) pill after drying is divided into two, carries out dozen powder according to the process of step (3) respectively and prepares pill.Merge
Obtain loading the pill of whole brufens afterwards, it is encapsulated up to ibuprofen sustained release capsules.
Raw materials used medicine or auxiliary material can be purchased by market in the preparation method of ibuprofen sustained release capsules provided by the invention
?.
Below with reference to embodiment, the present invention is further explained:
The preparation of 1 ibuprofen sustained release capsules of embodiment
The formula of ibuprofen sustained release capsules is as follows:
1000 parts of brufen, 0.4 part of stearic acid, 30 parts of povidone, 300 parts of cane sugar core.
The preparation method is as follows:
1) preparation of lubricant and adhesive
Stearic acid is added slowly to and is filled in stainless steel barrel of the dehydrated alcohol with agitating paddle, 5min, which is stirred at room temperature, makes it
It is completely dissolved, 5wt% stearic acid-ethanol solution is obtained, as lubricant；PVP K30 is added slowly to and fills anhydrous second
In stainless steel barrel of the alcohol with agitating paddle, 20min is stirred at room temperature and makes it completely dissolved, obtain 5wt% povidone-ethanol solution, makees
For adhesive.
2) the cane sugar core preparation of lubricant is loaded
Load weighted cane sugar core is moved into Chufa-type coating pan, and 5wt% stearic acid-ethanol solution is added to
In pressurized tank, start Chufa-type coating pan, it is after so that cane sugar core is reached optimal flow state in pot, the solution is disposable
It is continuous to spray into, until having sprayed.After hydrojet, naturally dry piller is constantly rotated with pot body.
3) the pill preparation of adhesive and brufen is loaded
A. it first sprays into 5wt% povidone-ethanol solution (adhesive) and is sprinkled into the cloth being sieved after piller liquid is uniform
Ibuprofen raw material dries 6.5min with pot body rotation.After beating powder, adhesive envelope ball is sprayed into twice, sealing ball every time must be with pot
Body is rotated while being stirred continuously to naturally dry.Beat powder amount: the 1/3 of brufen total amount.
B. it is dried in heated-air circulation oven, 35 DEG C of temperature, time 13h.12 mesh and 18 meshes are crossed respectively.
C. the pill after drying is divided into two, carries out dozen powder according to the process of step A, B respectively and prepares pill.Merge
The pill for obtaining loading whole brufens afterwards, is dried in heated-air circulation oven, and 35 DEG C of temperature, time 13h.It crosses respectively
12 mesh and 18 meshes.Encapsulated ibuprofen sustained release capsules to obtain the final product.
The vitro release comparative study of test example 1 self-control ibuprofen sustained release capsules and reference preparation
Embodiment 1 and reference preparation (producer: Sino-U.S. SmithKline) be situated between in pH6.0 medium, pH5.5 medium, pH6.8
Vitro release comparative study under the conditions of matter, method are as follows:
1 vitro release detection method of table
| Instrument | Digestion instrument |
| Dissolution medium | PH6.0 medium, pH5.5 medium, pH6.8 medium |
| Dissolve out volume | 900ml |
| Device | First method (basket method) |
| Revolving speed | 30rpm/min |
| Sample volume | Determining sampling amount is arranged according to instrument itself in 10ml |
| Temperature | 37℃±0.5℃ |
Sample time are as follows:
Sampling time point in 2 vitro release detection method of table
It is as follows to obtain result:
PH6.8 medium, f2=65.29；PH5.5 medium, f2=81.19；PH6.0 medium, f2=75.22, f2 value are all big
In 50, it was demonstrated that autonomous sample and the fitting of reference preparation dissolution curve are good, represent its discharge in vitro it is equivalent, in vivo
Curative effect is also most probably consistent (Fig. 1).
Comparative example 1
Ibuprofen sustained release capsules are prepared referring to the method for the Chinese patent embodiment 2 of 107184565 B of publication No. CN, are had
Body method is as follows:
1) the silica slow-releasing granules preparation of brufen is loaded
By 0.5g SBA-15, ultrasound 10- in 50mL ethyl alcohol is added in 0.2g polyethylene glycol 400 and 30mg methyl hexadecanoate
15min；Then 0.5g brufen is added into dicyandiamide solution, rotary evaporation of solvent obtains load cloth Lip river after stirring 4h at room temperature
Fragrant SBA-15 particle；By 0.5g hypromellose phthalate be dissolved in 50mL methanol-acetone solution (volume ratio 1:
1) in, the SBA-15 particle of 1g load brufen is then added into solution, after stirring 1h, rotary evaporation of solvent, of acquisition
It is spare that grain crushed 40 meshes；
2) the aperture polypropylene foam slow-releasing granules preparation of brufen is loaded
0.4g open-cell polypropylene particle foams, O.lg polyethylene glycol 400 and 20mg palm fibre are put into sour methyl esters, 50mL ethyl alcohol is added
Middle ultrasound 15-20min；0.5g brufen is added into dicyandiamide solution, solvent is evaporated under reduced pressure after stirring and obtains load brufen
Open-cell polypropylene particle foams；The IV acrylic resin of 0.3g is dissolved in 30mL ethyl alcohol, 0.9g is then added into solution
Load brufen open-cell polypropylene particle foams, stir 30min, solvent be evaporated under reduced pressure, the particle of acquisition crushed 40 mesh
Sieve is packed into capsule with the silica dioxide granule of load brufen after mixing to obtain the final product.
Comparative example 2
Ibuprofen sustained release capsules are prepared referring to 1 method of Chinese patent embodiment of 102114011 A of publication No. CN, are made
Preparation Method includes:
1. material prepares:
The micronization of a main ingredient brufen, l0 μm of partial size；
PVP K30 is added appropriate dehydrated alcohol to be made into 5wt% (w/w) solution by b, spare；
Stearic acid is added appropriate dehydrated alcohol to be configured to 5wt% (w/w) solution by c, spare；
2. preparing load pill core: taking the blank capsule core of recipe quantity to set in coating pan, the stearic acid dehydrated alcohol that c is obtained
Spray solution is in blank capsule core；
3. lamination method is added medicine to: successively spraying b and obtain povidone k30 ethanol solution, simultaneously micro mist is added in the hydrojet intermittent phase
Brufen after change is adhered to capsule core surface to brufen and repeats the above process, until brufen is added to finish, equipment continues
Operation 10 minutes；
4. it is 12 hours dry in 35 DEG C to take out obtained pellet.
5. loading capsule after intermediate detection, packing to obtain the final product.
Comparative example 3
Ibuprofen sustained release capsules are prepared referring to 1 method of Chinese patent embodiment of 106265601 A of publication No. CN, are made
Preparation Method includes:
In terms of 1000 sustained release preparations of ibuprofen, every 0.3g, raw material includes: brufen 300g, PVP K30 6g,
Hydroxypropyl methylcellulose 30g, blank pill heart 62g, suitable ethyl alcohol；
The preparation method of sustained release preparations of ibuprofen includes the following steps: to prepare particle using centrifugal granulation, by blank pill
The heart pours into centrifugal granulator, opens centrifugal turntable, and revolving speed is set as 100-120rpm, opens peristaltic pump, adjusts atomization pressure
Power, spray into povidone, ethyl alcohol, while be sprinkled into brufen, hydroxypropyl methylcellulose is added medicine to, to brufen medicine-feeding after, will
Pellet is dried, and the pellet between -26 mesh of 16 mesh is taken to carry out capsule filling, then aluminum-plastic packaged.
The vitro release comparative study of test example 2 self-control ibuprofen sustained release capsules, comparative example and reference preparation
Embodiment 1, comparative example 1-3 and reference preparation (producer: Sino-U.S. SmithKline) be situated between in pH5.5 medium, pH 6.0
Vitro release comparative study under matter, pH6.8 ambient condition, method and sample time, testing result was such as with table 1 and table 2
Under:
Vitro release under 3 pH5.5 ambient condition of table
Similarity: similar factors are calculated with the accumulation dissolution rate of 1h, 1.5h, 3h, 4h, 5h, 8h.
Vitro release under 4 Ph6.0 ambient condition of table
Similarity: similar factors are calculated with the accumulation dissolution rate of 1h, 1.5h, 3h, 4h, 5h, 8h.
Vitro release under 5 pH6.8 ambient condition of table
Similarity: similar factors are calculated with the accumulation dissolution rate of 30min, 45min, 60min, 90min, 120min.
As the result is shown: embodiment 1, comparative example 1, comparative example 2, comparative example 3, reference preparation, respectively pH5.5, pH6.0,
Release in pH6.8 difference dissolution medium is compared, it is not difficult to find that embodiment 1 and reference preparation are in 3 kinds of media
Release similarity is high, it was demonstrated that ibuprofen sustained release capsules of the invention closer to reference preparation, quality and efficacy of products more with
Reference preparation is close.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of preparation method of ibuprofen sustained release capsules, which comprises the steps of:
Step A: wrapping up lubricant solution in blank capsule core, dries, and obtains the piller of load lubricant；
Step B: binder solution is wrapped up on the piller of load lubricant, then the brufen of wrapping portion formula ratio, dries；
Wrap up binder solution envelope ball twice, dry, sieving obtains the pill of loading section brufen；
Step C: wrapping up binder solution on the pill of loading section brufen, then wraps up the brufen of remaining formula ratio,
It dries；Wrap up binder solution envelope ball twice, dry, sieving is packed into capsule shells, obtains ibuprofen sustained release capsules.
2. preparation method according to claim 1, which is characterized in that the lubricant solution is to contain 3wt%~8wt%
Stearic ethanol solution, described adhesive solution are the ethanol solution containing 3wt%~8wt% povidone.
3. preparation method according to claim 1, which is characterized in that the blank capsule core is cane sugar core.
4. preparation method according to claim 1, which is characterized in that the blank capsule core, lubricant, adhesive, Bu Luo
Fragrant formula ratio ratio is (100~500): (0.2~0.6): (10~50): (800~1200).
5. preparation method according to claim 1, which is characterized in that the pot body revolving speed when package is 20~80Hz,
Spray gun pressure is 0.20~0.80MPa.
6. preparation method according to claim 1, which is characterized in that the temperature of the drying is 25~45 DEG C, and the time is
10~15h.
7. preparation method according to claim 1, which is characterized in that the sieving was 12 mesh~18 meshes.
8. preparation method according to claim 1, which is characterized in that in stepb, the brufen of part formulation amount is phase
When in the brufen of formula total amount 1/4 to 1/2.
9. preparation method according to claim 1, which is characterized in that in stepb, in the brufen of part formulation amount,
Each 1.0~the 3.0min of injecting time of the powder of early period 20%, each 2.0~4.0min of injecting time of the powder in later period 80%.
10. preparation method according to claim 1, which is characterized in that step C specifically: by loading section brufen
Pill is divided into two parts, and is then wrapped up the brufen of remaining formula ratio respectively, is dried；Wrap up binder solution envelope ball twice, it is dry,
Sieving merges two parts of pills, is packed into capsule shells, obtains ibuprofen sustained release capsules.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327309A (en) * | 2019-07-17 | 2019-10-15 | 珠海润都制药股份有限公司 | A kind of ibuprofen slow-release piller that viscous ball does not occur |
| CN111481527A (en) * | 2020-04-30 | 2020-08-04 | 福建太平洋制药有限公司 | Method for improving yield of ibuprofen sustained-release capsule finished product |
| CN115120575A (en) * | 2022-07-01 | 2022-09-30 | 云鹏医药集团有限公司 | Preparation method of ibuprofen sustained-release capsule |
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| CN110327309A (en) * | 2019-07-17 | 2019-10-15 | 珠海润都制药股份有限公司 | A kind of ibuprofen slow-release piller that viscous ball does not occur |
| CN110327309B (en) * | 2019-07-17 | 2023-02-10 | 珠海润都制药股份有限公司 | Ibuprofen sustained-release pellet without pill sticking |
| CN111481527A (en) * | 2020-04-30 | 2020-08-04 | 福建太平洋制药有限公司 | Method for improving yield of ibuprofen sustained-release capsule finished product |
| CN111481527B (en) * | 2020-04-30 | 2022-05-06 | 福建太平洋制药有限公司 | Method for improving yield of ibuprofen sustained-release capsule finished product |
| CN115120575A (en) * | 2022-07-01 | 2022-09-30 | 云鹏医药集团有限公司 | Preparation method of ibuprofen sustained-release capsule |
| CN115120575B (en) * | 2022-07-01 | 2023-05-30 | 云鹏医药集团有限公司 | Preparation method of ibuprofen sustained-release capsule |
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