CN109963497A - Advanced respiration monitor and system - Google Patents
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- CN109963497A CN109963497A CN201780053679.2A CN201780053679A CN109963497A CN 109963497 A CN109963497 A CN 109963497A CN 201780053679 A CN201780053679 A CN 201780053679A CN 109963497 A CN109963497 A CN 109963497A
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/0245—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
- A61B5/02455—Detecting, measuring or recording pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals provided with high/low alarm devices
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- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
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Abstract
Disclosed is a kind of bio-impedance testing system: stablizing high-frequency current generator and be connected to piece group electrode via patient's cable.Electrode is connected to adaptive circuit, voltage signal produced by which is adjusted, and is converted into digital form.Firmware executes signal acquisition, and forwards the data to device.
Description
Citation of related applications
The application also requires U.S. Provisional Application No. 62/369583 (to submit on August 1st, 2016, entitled " Advanced
Respiratory Monitor and System ") priority, it is completely combined.
Technical field
The present invention is directed to the device and system for monitoring breathing.Specifically, present invention is alternatively directed to for using impedance
To monitor the device and system of reparation.
Background technique
Physiological moniyoting-history and evolution
Patient monitoring is essential, because it provides the alarm to patient deterioration, and allows the chance of early intervention, pole
The earth improves patient's prognosis.For example, modern monitoring arrangement is able to detect abnormal heart rhythm, blood oxygen saturation and body temperature, can lead to
Know clinician about unperceived deterioration originally.
The earliest record of patient monitoring discloses ancient Egyptian and was known that peripheral vessels pulsation and the heart early in B.C. 1550
Correlation between jump.It is just obtained subsequent aobvious for the use of monitoring as Galileo measures pulse frequency using pendulum after 3000 years
Write progress.In 1887, Waller determine he can passively be recorded by using electrode the electrical activity across thoracic cavity and by signal with
Activity from heart interrelates.The electric signal that is found to be of Waller is paved the way as the method for measurement physiological signal.But
Scientist still takes time just to recognize the advantages of physiological signal is monitored in clinical setting.
In nineteen twenty-five, MacKenzie emphasizes that the continuous of physiological signal (such as pulse frequency and blood pressure) is recorded and monitored important
Property.He especially emphasizes that the graphical representation of these signals is important in the assessment of patient condition.In the 1960s, with
The appearance of computer, patient monitor obtained with the addition that shows of real-time graph of multiple vital signs of record simultaneously
It improves.Alarm is also coupled in monitor, and is triggered when signal (such as pulse frequency or blood pressure) reaches some threshold value.
First patient monitor during surgery uses patient.It is improved as patient's prognosis is presented, vital signs
Monitoring expand to other regions of hospital, such as intensive care unit and emergency department.For example, pulse oximetry is for the first time in operating room
In be widely used as non-invasively continuously measuring the method that the oxygen of patient closes.Pulse oximetry rapidly becomes the execution of general anesthesia
Nursing standard, and then expand to the other parts of hospital, including recovery room and intensive care unit.
The growth for improving patient monitoring is needed
The quantity to the critical patient of emergency department is sent to increase with big rate, and these patient requests pay close attention to.It is estimated,
Patient requests' Critical Care program of 1-8% in emergency department is performed, such as cardiovascular procedures or chest and breathing program (machinery
Ventilation, conduit insertion, arterial cannulation).
Physiology score (such as mortality probability model (MPM), acute physiology and chronic healthy education (APACHE), letter
Change acute physiology score (SAPS) and therapy intervention points-scoring system (TISS)) significantly improving in presented patient's prognosis.
It is pre- by monitoring that sufferer is improved using physiology score and vital signs in disease early stage, even before organ failure or shock
Afterwards.The identification for paying close attention to that patient is allowed to degenerate of patient and the execution of appropriate therapy.
But current methods of marking is no in about 15% ICU patient accurately to predict patient's prognosis, and to breathing
The patient of intensive care unit (it provides nursing in the hospital with a large amount of patients with acute respiratory failure) may be worse.This
Outside, the difference of the vital signs (such as blood oxygenation) currently monitored occurs in the progress middle and later periods for breathing or recycling damage.Suffer from
The initial stage illness of person's deterioration is usually the variation of the respiratory effort or breathing pattern of patient.
Respiratory rate is identified as the life index of patient health, and is used to assess patient's states.But the independent nothing of respiratory rate
Method indicates significant physiological change, such as the variation of respiratory capacity.The measurement gone out from continuous measurement gained shows to have a wide range of
Clinical application in determine patient's states very high potential.But there is currently no accurately can advantageously determine respiratory capacity
Abundant system, this excites the needs for that can track the noninvasive respiration monitor of the variation of respiratory capacity.
The shortcomings that current method
Currently, the respiratory state of patient uses such as vital capacity determination and end-tidal CO2The method of measurement etc. monitors.These sides
Method be generally inconvenient to using and it is inaccurate.Although end-tidal CO2It monitors during anesthesia and suffers from the intubation of a variety of environment
It is useful in the assessment of person, but it is inaccurate to non-ventilation patient.Spirometer and pneumotachograph are being surveyed
Amount aspect is restricted, and makes great efforts to patient and the appropriate training of clinician's progress is extremely related.Effective training and quality assurance
It is required to success vital capacity determination.But the two premises are not necessarily implemented in clinical practice, as they are studying
In study and pulmonary function laboratory like that.Therefore, quality assurance is to prevent misleading results essential.
Vital capacity determination is the pulmonary function test (pft) most commonly executed.Spirometer and pneumotachograph, which can provide, exhales
The direct measurement of pipette.It is related to assessing patient by measuring air capacity or flow when air enters and leaves patient body
Breathing pattern.Vital capacity determination program and movement are by American Thoracic association (ATS) and Europe breathing association (ERS) come standard
Change.Vital capacity determination is capable of providing the important measure for assessing respiratory health and diagnosis breathing pathology.Mainstream spirometer
Major defect is that they require patient to breathe by pipe, makes it possible to measure the amount and/or flow rate of its breathing.By setting
It is standby to carry out breathing introducing to the resistance of respiratory flow, and change the breathing pattern of patient.Therefore, it is not possible to use these devices
Accurately measure the eupnea of patient.Breathing, which is carried out, by equipment requires conscious compliance patient.In addition, in order to record
Measurement proposed by ATS and ERS, patient must be subjected to laborious respiratory movement, and most of old, nascent and COPD patients are arranged
Except in addition to it can be subjected to this inspection.The result of program according to patient make great efforts and train and operator's skills and experience be also
Extremely variable.ATS also recommended the extensive training to the health care professional for implementing vital capacity determination.In addition, in many
Section doctor does not explain the technical ability from pulmonary function test (pft) data obtained accurately.According to described in American Thoracic association, subject
The largest source of interior variability is the incorrect execution of test.Therefore, become between patient in many patients in pulmonary function test (pft)
The opposite sex passes through produced by mistake.Important blank is filled up in breathing monitoring based on impedance, because of current vital capacity determination measurement
Because patient cooperation and the requirement breathed by pipe cannot provide continuous measurement.Therefore, it is necessary to one kind in non-intubation
To the dress for extending time cycle (comparing vital capacity determination test, continue one minute or less) offer near real-time information in patient
It sets, can show that the variation of breathing relevant to challenge test or therapy intervention.
In order to obtain acceptable vital capacity determination measurement, such as ATS prescribed by standard, health care professional must have
Extensive training and receive refresher course.One group shows acceptable vital capacity determination measurement for participating in defending for training seminar
Raw health professional is significantly larger (41% and 17%).Even acceptable vital capacity determination is measured, by attending physician to data
Explanation be also considered incorrect in 50% time by Pulmonary Medicine doctor.However, it is noted that the auxiliary from computerized algorithm
Show explaining the improvement in pneumatogram when collecting the measurement of abundant vital capacity determination.
Screw up discipline is that primary care clinic obtains acceptable vital capacity determination measurement and carries out needed for accurately explaining.
But it is unreasonable and inefficient for training a large amount of personnel and implementing the resource of satisfactory quality assurance.Even special
In research environment, technical staff's performance declines over time.
Other than the mistake caused by because of patient and health care worker, vital capacity determination includes system mistake,
It destroys respiratory variation measurement.It is had shown that according to the useful measurement of the breathing of breathing pattern and variability through air flue attachment
(such as mask and ozzle) complicates.In addition, the related uncomfortable and inconvenient resistance during the measurement using these devices
Only they are used for routine measurement or as monitored for prolonged periods of time devices.Other less intrusive technologies (such as thermal resistor or answer
Become instrument) it is used to the variation of premeasuring, but these methods provide the poor information about respiratory capacity.Breathing zone also shows that measurement is exhaled
Prospect in terms of pipette, but marshalling shows that they are less accurate, and has than the measurement from impedance pneumography
Big variability.Therefore, it is necessary to a kind of systems, can be measured with minimum patients and clinicians interaction long time period
Amount.
Pulmonary function test (pft) and preoperative, postoperative care
Preoperative care, which concentrates on, identifies that patient can be placed in risk during operation and make those risks by which Patient Characteristics
It is minimum.The step of being taken in medical history, smoking history, age and other parameters regulation preoperative care.Specifically, older patients with
And the patient with tuberculosis under the respirator for being placed in surgical operation when be likely to be at the risk of respiratory complication.In order to remove
These patients of surgical operation execute pulmonary function test (pft) (such as vital capacity determination), give more information to determine that patient is
It is no to utilize respirator.Chest x-ray can also be obtained.But these test cannot during surgery between or be anesthetized suffer from
Person cannot or be reluctant to replicate in the patient of cooperation.Test in environment after surgery may be uncomfortable and to Rehabilitation
It is destructive.
End-tidal CO2And patient monitoring
End-tidal CO2It is another useful metrics for determining the lung state of patient.The value is expressed as percentage or part is pressed
Power, and continuously measured using carboloy dioxide analysis monitor (it can be coupled with other patient monitoring devices).These instruments produce
Raw capnogram, indicates CO2The waveform of concentration.It is dense that capnography compares the carbon dioxide in expiration and arterial blood
Degree.Then capnogram is analyzed, to diagnose adjoint the problem of breathing, such as hyperventilation and hypoventilation.End-tidal
CO2In trend to assessment respirator performance and identify pharmaceutical activity, with the technical issues of intubation and airway obstruction is special
It is not useful.Anesthetist association, the U.S. (ASA) requires end-tidal CO2It is supervised in any time using tracheal catheter or laryngeal mask
Depending on, and also greatly encourage to be related to the treatment of general anesthesia.Capnography also it is verified for patient ventilation prison
Depending on more more useful than pulse oximetry.However, it is usually inaccurate in non-ventilation patient and is difficult to realize, and
Other supplement breathing monitoring methods have wittrgreat utility.
Summary of the invention
The present invention overcome with current strategies and the associated problems and disadvantages of design, and provide the new work for monitoring patient
Tool and method.
Apparatus of the present invention are preferably a kind of continuous non-invasive respiration monitor, provide every point of ventilation (MV), tidal volume
(TV) and the quantitative and graphical information of respiratory rate (RR).In previous device, device requires clinician before use device
The single-point calibration of spirometer or respirator is executed to each patient.It carries out the step and realizes that the accurate volumetric of MV and TV is surveyed
Amount.Alternatively, in previous device, it is desirable that the collection of the reference data of eupnea, wherein being calculated near real-time subsequent
The display of transmitting and the breathing (TV and MV) of the percentage as personal normal baseline.Although being obtained using similar techniques
Numerous unsuccessful trials of accurate clinical useful measurement, but essence cannot be accessed in the case where being not necessarily to patient's particular calibration
Really measurement.Apparatus of the present invention eliminate patient's particular calibration to respirator or obtain the needs of normal baseline, and realize this
Technology to previously not on respirator or without eupnea or cannot with collect the patient's that cooperate of normal baseline
It uses.This realizes use of the device to the patient after respiratory distress or calmness or another therapy or processing.
Based on the feedback for collecting accumulated clinical research using extensive clinical data from the past 3 years, the device is at this
The needs referred to this single-point calibration or normal baseline are eliminated in invention.Accurate respiratory capacity data quilt is allowed to the modification of device
It is supplied to user, is referred to without single-point calibration or normal baseline.
The device is noninvasive respiration monitor, shows the lung volume of relative time to graphically, and reports breathing
Rate, tidal volume and every point of ventilation, refer to without single-point calibration or normal baseline.
It is proposed that invention includes:
Bio-impedance testing system: stablize high-frequency current generator and be connected to piece group electrode via patient's cable.Electrode connection
To adaptive circuit, voltage signal produced by adjusting, and it is converted into digital form.Firmware executes signal acquisition, and
And forward the data to computing device.
In one embodiment, the present invention utilizes the computing device for executing signal processing and calibration, and runs figure use
Family interface (GUI).Computing device obtains user's input from touch screen by dummy keyboard and mouse.GUI is for recording patient's number
According to, and show the scalar value and trend of breathing trace and every point of ventilation, tidal volume and respiratory rate.In other embodiments,
Can be used including microprocessor other computer systems or device (such as embedded or single board computer, cellular phone or
Any computing device).
Single patient uses piece group electrode: electrode is arranged to be placed on trunk.It transmits electric current, and records impedance survey
Amount.In a preferred embodiment, this is the printed circuit board slice group with single connector, simply and is accurately placed with realizing.
In one embodiment, the device is estimated in health care facility (such as postoperative care and critical care unit)
Health care professional be used to monitor the breathing of adult (more than 21 years old).In one embodiment, which is used for paediatrics
Or neonatal patient.In one embodiment, which is used for family or other flowing environments.In one embodiment, the dress
It sets for body-building, health or environment of observation, wherein measuring will have value without the input from health care professional.
In one embodiment, the auxiliary of other clinical information is used as from the measurement for proposing to invent.Implement at one
In example, measurement is for judgement support, automation or for health care professional, nursing staff or measured
People.
One embodiment of the present of invention is directed to respiration monitoring system.The system includes computing device and is suitble to be coupled to trouble
The electrode slice group of person.At least one graphic user interface (GUI) that computing device includes processor, is communicated with processor with
And at least one sensor input communicated with processor.Electrode slice group can be coupled to sensor input, receive from meter
It calculates the electric signal of device and bioimpedance signal is detected by the trunk of patient.Processor is based on detected bio-impedance
Signal determines that every point of ventilation (MV), the percentage of predicted MV, moisture are taken a breath (TV), the percentage of predicted TV, exhaled in real time
The percentage of suction rate (RR) and predicted RR, the collected benchmark without the calibration to given value or during normal ventilation
And it is not necessarily to patient cooperation.GUI exports every point of ventilation (MV), the percentage of predicted MV, moisture ventilation (TV), institute in advance in real time
It surveys in the percentage of the percentage of TV, respiratory rate (RR) and predicted RR and determines one or more.
In a preferred embodiment, which provides the finger of at least one of hyperventilation, normal ventilation and hypoventilation
Show.Preferably, which provides at least one hypoventilation, breath signal waveform based on respiration inhibition caused by class opium
Change, the instruction of the variation of air-breathing expiration ratio and the development of flateau.Preferably, computing device is suitble to unite by patient population
It counts and provides the continuous measurement of ventilation within one minute be entered into device.Demographics is preferably the height of patient, weight
At least one of with gender.Preferably, computing device is adapted to provide for the continuous measurement of ventilation, without the patient to respirator
The benchmark of particular calibration or patient in eupnea.
In a preferred embodiment, computing device is suitble to provide the continuous measurement of ventilation immediately when attaching electrodes are to device,
Without typing consensus data.Preferably, patient cooperation or the control to patient respiratory are not required.Preferably, should not
The calibration for asking device to read known breath device, spirometer or pneumotachograph.Computing device preferably further includes HR-
RR cut-off filter.Preferably, HR-RR cut-off filter filters breathing and heart signal based on target heart rate cut off
Wave.In a preferred embodiment, heart rate cut off is one of 30,40,50 or 60 jump (bpm) per minute.
Preferably, heart rate cut off based on patient demographics, MV or is predicted in the percentage and shallow fast breathing index of MV
At least one.Heart rate cut off is preferably manually entered, or is automatically updated by computing device.In a preferred embodiment,
HR-RR cut-off filter provide the measurement of gain of impedance signal, the impedance trace shown on GUI absolute value it is scalable because
At least one of son, the reduced instruction of tidal volume, the instruction of level of sedation and diagnosis of respiratory disease.
Preferably, which further includes at least one sense of hearing or visual alarm.Preferably, at least one sense of hearing or vision report
It is alert to be based at least one of patient disease state, physician's assessment, clinical or Curing circumstance, physiological measurements or external reference
To be arranged.Preferably, at least one sense of hearing or visual alarm are adaptive.
Prediction MV is based preferably on the height, weight and gender of patient to calculate.Preferably, prediction MV calculating further includes suffering from
At least one of the specific physiology of person, dissection, form or topology.In a preferred embodiment, the system be suitable for wake, be not intended to
Know, there is consciousness, the patient of one of them uses after intubation, respiratory distress or calmness on terminal stage, respirator.It is preferred that
Ground, the system are noninvasive.The system preferably further includes patient's cable that electrode slice group is coupled to computing device, wherein suffering from
Person's cable is suitble to transmit high-frequency current to patient via electrode slice group.
The other embodiment of the present invention and advantage partially propose in the following description, and part will be aobvious by this description
And be clear to or can understand from implementation of the invention.
Detailed description of the invention
The front view of the embodiment of Fig. 1 the device of the invention.
The rearview of the embodiment of Fig. 2 the device of the invention.
The embodiment of Fig. 3 patient's cable.
The embodiment of Fig. 4 electrode slice group.
The embodiment of the preferred placement of electrode slice group on Fig. 5 trunk.
The embodiment of Fig. 6 A-E graphic user interface (GUI).
Specific embodiment
It proposes that invention is a kind of noninvasive respiration monitor, shows the lung volume of relative time to graphically, and
Report every point of ventilation, tidal volume and respiratory rate, without the calibration to respirator, spirometer or pneumotachograph, and
And without obtaining normal baseline.This realizes this technology to previously not on respirator or without eupnea or cannot be with receipts
The use for the patient that collection normal baseline is cooperated.
In one embodiment, propose that invention includes:
Bio-impedance testing system: stablize high-frequency current generator and be connected to piece group electrode.Electrode is connected to adaptive circuit,
Voltage signal produced by it is adjusted, and it is converted into digital form.Firmware executes signal acquisition, and forwards the data to
Processing unit.
Processing unit: processing unit (such as plate, smart phone, computer, dedicated unit, microprocessor or another
Computing device) signal processing and calibration are executed, and run graphic user interface (GUI).Processing unit by dummy keyboard and
Mouse obtains user's input from touch screen.GUI shows breathing trace and every point of ventilation, tide for recording patient data
The scalar value and trend of tolerance and respiratory rate.
Single patient uses piece group electrode: electrode is arranged to be placed on trunk.It transmits electric current, and records impedance survey
Amount.
In one embodiment, monitor preferably has the unit ruler of 12 inches (h) × 12 inches (w) × 6 inch (d)
Very little and 8 pounds of unit weight, but unit can have another size.The length of patient's cable is substantially 8 feet, still
Cable can have another length.The length of piece group be it is adjustable, to be suitble to large-scale patient.In one embodiment
In, data are collected and are wirelessly communicated to device (such as cellular telephone screen, smartwatch, pager or another portable
Receiver).
In a preferred embodiment, user interface preferably has LED backlight, indicator device and/or capacitance touch screen
Display.The device preferably has following measurement accuracy:
Every point of ventilation (MV)-is better than 20%
Tidal volume (TV)-is better than 20%
Respiratory rate (RR)-is better than 20%
Or more preferably
Every point of ventilation (MV)-is better than 15%
Tidal volume (TV)-is better than 15%
Respiratory rate (RR)-is better than 5% or breathes once every minute
In one embodiment, which preferably exports the Patient Auxiliary Current for meeting ANSI/AAMI 60601-1.At one
In embodiment, the component of device is not necessarily to sterile shipment.In one embodiment, piece group component can be sterile, and pass through
Hot-pressing processing or gas disinfection.Device is not estimated for patient contact, and not it is expected that uses inside aseptic area.
In one embodiment, electrode slice group is estimated for being up to 24 hours with skin contact.In one embodiment, electrode slice group can
It is up to one week with skin contact.In one embodiment, piece group is preferably manufactured from polyester (PE).In piece group, it may be present
Foam baked donut contacts patient and is made of polyester.In a preferred embodiment, piece group is by bio-compatible glycerol hydrogel
Electrical integrity for being connect with patient.In one embodiment, the operating temperature range of monitor is 40-900F, with
And operating humidity range is 20-80% (not solidifying), wherein storage temperature range is -4-1490F and storage humidity range are
20-80% (does not solidify).
In a preferred embodiment, piece group has 4-900The preferred operating temperature range of F, 20-80% (not solidifying) it is excellent
Select operating humidity range, preferably storage temperature range=14-1220The preferred storage humidity model of F and 20-80% (not solidifying)
It encloses.
Preferably, disinfectant wiping can be used in the exposed surface of monitor and cable.Business level cleaning solution can be used in display screen
To clean.Preferably, which there is the power of 100-240 V, the input voltage of 50/60 Hz and frequency and < 600 W to disappear
The preferred power requirement of consumption.
The device is preferably able in following environment: ICU, operation is calm, is monitored anesthetic care, No operation room fiber crops
Liquor-saturated, Perinatal Therapy environment, operating room, general hospital building, clinic, long-term care facility, family, gymnasium, recovery centre or uncommon
Hope any other environment for executing breathing monitoring.It proposes that low MV is reported in invention, is the definition of hypoventilation (respiration inhibition).
Monitor that MV help detects respiration inhibition using proposing to invent.It is proposed that invention provides the instruction of breathing damage.
The MV measurement as provided by the device preferably aids in respiration inhibition caused by testing and evaluation class opium.Using being proposed
The hypoventilation of invention and/or the early detection of hyperventilation can help to generally improve the delivery of respiratory care and health care.
The device preferably reports high MV, is the definition of hyperventilation, thus provide to respiratory failure, diffusion gradient, septicemia with
And the understanding with the increase associated other conditions of work of breathing.The device preferably provides objective data related with respiratory state,
It can improve patient safety.Variation of the device preferably in bedside or remote notification clinician about respiratory state.It should
Device preferably provides the additional respiration information in non-intubated patient, can enhance patient safety.
In one embodiment, which preferably measures and shows the minute volume (MV) of the patient of the previous monitoring that breathes no more, moisture
One or more of amount, advanced respiration parameter, general respiratory state and the qualitative assessment of variation of respiratory state.In this reality
Apply in example, when monitor start when, patient can hypoventilation, normal ventilation, hyperventilation spectrum any position or presentation
Various respiratory mode it is any.In a preferred embodiment, within by one minute in patient demographics typing monitor
The continuous measurement of ventilation is provided.In one embodiment, which preferably provides ventilation when attaching electrodes are to device immediately
Continuous monitoring, without requiring consensus data.In a preferred embodiment, the device preferably have abundant precision and easily
In use, wherein only by height, weight and gender input device, without requiring benchmark of the patient in eupnea or adopting
With the calibration of the measurement from respirator or spirometer or pneumotachograph, which preferably provides a kind of dress for the first time
It sets, uses when can be in the one or more that patient is in following clinical situation: in terminal stage, there is significant breathing
Distress stops with obvious respiratory failure, with apneic attack, by breathing, stops by heartbeat, has the mistake of the significant rhythm of the heart
Often, with heart failure, the hyperventilation from septicemia, with because from pulmonary embolism air hunger or other reasons caused by
Hyperventilation, with hyperventilation or hypoventilation from unknown cause.
In one embodiment, which preferably reports low MV, is hypoventilation (respiration inhibition, breathing damage)
Definition.In one embodiment, which preferably identifies by respiration inhibition caused by class opium or draws in class opium
The patient of the risk of the respiration inhibition risen.To a miracle, in a preferred embodiment, which preferably passes through quantization class opium
One or more inhalation doses after MV or the absolute value of variation of MV patient's finger of basic class opium sensibility is provided
Show, and because the use of device can be after class opium be inhaled into there is no to the needs for collecting benchmark or calibration
It initiates, to assess and quantify hypoventilation (respiration inhibition, breathing damage).In a preferred embodiment, using the prison of the device
Depending on preferably being initiated in the patient with doubtful breathing damage or doubtful class opium overtreatment, and is assessing and/or recovering
Period accurately monitors.Clinical assessment is damaged or breathed with breathing by nursing staff from the data for proposing to invent
The patient for a possibility that damaging (hypoventilation or hyperventilation) uses, to initiate to treat and observe simulation, positioning, class opium
Or in benzodiazepine reverse, oxygen sucking, CPAP, BiPAP, furosemide, Gao Liudong oxygen or another respiratory therapy
One or more effects.
In a preferred embodiment, the device is right in the case where being preferably provided in without calibration or the collection of reference measurement
Patient carries out method (such as 80/40 method, wherein maintaining the % of MV < 80 MV before class opium dosage of risk stratificationPRED
Patient more than 2 minutes is considered " risky " and maintains the % of MV < 40 within 15 minutes after class opium dosage
MVPREDAt least 2 minutes patients are considered to have " low MV " or " dangerous ").The device preferably props up after surgical operation
80/40 risk stratifying method is held, to help to detect the patient of the risk of the respiration inhibition caused by the class opium, without calmness
Benchmark before or the calibration to respirator.Previously, this risk stratification may be only in patient to the preoperative calibration of spirometer
It is carried out after either normal baseline is collected or communicatively calibrates with respirator.The present invention makes layering can be to any postoperative patient
Person's (wherein respiratory state is modified and is usually anesthetized agent, class opium or sedative and damages) carries out.This embodiment
It realizes in environment after surgery and identifies which patient is in the risk of respiration inhibition, be included in the identification of general hospital building in breathing suppression
The patient of the risk of system.Preferably, the information about patient respiratory state will be passed to central nursing station or nurse or another
Phone entrained by nursing staff.In one embodiment, information relevant to patient respiratory state and risk is by nurse call station
System is transmitted.In one embodiment, information to any wired or wireless connection of concentrated position by forwarding, for list
Solely analysis or with other physiology, demographics and laboratory information group pair.Preferably, propose that invention is helped to be greater than 70%
Sensitivity is greater than 75% sensitivity, is greater than 80% sensitivity, more preferably larger than 85% sensitivity and most preferably more than 90% spirit
Sensitivity identifies the patient of the risk of the respiration inhibition caused by the class opium.It is proposed invention help be greater than 70% sensitivity,
Greater than 75% sensitivity, it is greater than 80% sensitivity, is greater than 85% sensitivity, more preferably larger than 90% sensitivity and most preferably big
The patient of respiration inhibition caused by will not forming class opium is identified in the postoperative precision of 95% sensitivity.
To a miracle, in a preferred embodiment, the precision of the device is preferably permitted without device to patient's special datum
Or known breath device, spirometer or the independent of pneumotachograph reading are calibrated and without in the case where patient cooperation
It uses.Pass through the device, it is preferable that patient cooperation or the control (such as passing through patient or external respirator) to patient respiratory
It is required to the measurement for providing breathable properties.This allows monitor (wake for any patient condition, there is consciousness, be in
Intubation etc. in terminal stage, respirator).
In this embodiment, which not only reports MV, TV and RR, but also based on patient's size come address prediction MV
Percentage.In a preferred embodiment, the patient demographics of one or more of height, weight, gender are entered device
In, and predict that MV is calculated based on formula (such as ideal body weight or body surface area).Calculated MVPREDThen it is used to base
Its percentage (%MV for predicting every point of ventilation is converted into the measured MV of the live signal of patient respiratoryPRED), and be nursing
Personnel provide the instruction of respiratory state, corrected to patient's size and gender, and realize the percentage based on normal ventilation
The foundation of the agreement of ratio.
Patient with MV < 40% is preferably identified as the increase risk in respiration inhibition by the device.The device is preferred
Ground helps to measure the air flue movement during performing the operation calmness to the efficiency of respiratory state, without preceding calibration or benchmark.The device
Instruction is preferably aided between the needs of the air flue movement operation killing period.The device preferably aids in quantization sedative and class crow
Influence of the piece between the respiratory state operation killing period.To a miracle, which is preferably able to accurately to report minute volume (MV), pre-
The percentage for surveying minute volume (MV), without preoperative benchmark or independent calibration.The device preferably aids in quantization anesthetic to killing period
Between the influence of respiratory state and the realization of the device can be initiated during the conveying of sedative or anesthetic.Preferably,
Compared with the capnography measurement during calm/monitored anesthetic care/of operation and the anesthesia of No operation room, device measurement more may be used
It can be used by ground.The device preferably aids in the respiration inhibition that identification receives the opioid patient of PCA.The device, which preferably aids in, to be commented
Estimate the respiratory state for receiving the opioid patient of PCA.The device preferably measures influence of the benzene phenodiazine to respiratory state.The device
Preferably influence of the measurement class opium to respiratory state, and can be to the uncooperative patient of respiratory distress or obvious respiratory failure
It initiates immediately, and is used to report according to quantitative manner and improves or deteriorate.The device is preferably able to form personalized pain association
The basis of view.In one embodiment, which preferably drives drug overtreatment agreement, and is used to assess drug overtreatment
In receive health therapy the effect of, prompt additional dose, or determine to the needs of intubation.
In one embodiment, which preferably measures influence of the neuromuscular blocking agents to respiratory state.At one
In embodiment, which preferably measures influence of the anesthetic to respiratory state.The device preferably provides MV measurement, is ratio
The index of the respiration inhibition of SpO2 earlier.When detecting respiration inhibition, proposes that the MV measurement of invention has and surveyed than carbon dioxide
Fixed better sensitivity and reliability.When detecting the variation of respiratory state, device MV measurement has more than CO 2 measuring
Good sensitivity and reliability.When defining respiration inhibition, hypoventilation, breathing damage, device MV measurement has than respiratory rate
Better sensitivity and specificity.In a preferred embodiment, in the multiple environment for including hospital building, PACU, endoscopy,
It is proposed the respiration inhibition that invention is identified by about 80% patient that independent respiratory rate measurement is lacked.The trunk of device
Electrode, which is placed, preferably makes occuring as at least for disagreeable alarm.
HR-RR cut-off filter
For the impedance data in remove device pretreatment during heart and the isolated default filter of breath signal set
Set the rate in 40 bpm.In sub-fraction patient (such as sportsman), heart signal has the base that can be lower than 40 bpm
Frequently (heart rate).In other patients's (such as pediatric patients), respiratory rate can be higher than 40.In order to improve the performance in this kind of patient,
In proposed device, customization filtering can be used to that device is allowed preferably to separate breathing and heart signal.This customization filtering energy
Enough it is embodied as adaptable filter or comprising with various HR/RR cut offs (such as bpm such as 30,40,50,60, referring to figure
The filter group of filter 6E).
In one embodiment, RR/HR ends continuously (such as larger patient with smaller cut-off) or as rank
Jump function (such as it is adult with paediatrics, based on weight, based on height, be based on BSA) be based on patient's size.In one embodiment,
HR/RR cut-off passes through the actual measurement of HR or RR or both based on one of selection criteria (such as Patient height and weight)
To refine.In one embodiment, cut-off is based on HR and RR, and is refined by patient's size.In either case, HR
And/or the estimated RR of size can be perhaps manually entered from clinical assessment or from HR and RR from external device (ED) into device
Input (such as from BiPAP, respirator etc.) calculates, or from the externally measured (such as from BiPAP or breathing of HR or RR
The RR of the device perhaps HR from EKG or pulse oximeter) it is automatically imported or by requiring from RVM and pulse oxygen
The consistent measurement of another proof of saturation degree instrument or electrocardiogram or plethysmogram or pulse frequency is to prove HR.Implement at one
In example, HR using the one or more of the frequency in signal, the difference from known RR frequency, with the ratio of RR frequency and HR with
The difference of the size of the variation for the impedance that RR is carried out determines.In one embodiment, the % or MV of predicted MV can be used to it is real
When define HR/RR cut-off (for example, if %MV prediction it is higher, ending can be higher, and if %MV prediction it is lower, end
It can be lower).
In one embodiment, HR/RR cut-off can be adjusted based on shallow fast breathing index (RSBI=RR/TV), so that such as
Fruit RSBI higher, then end automatically be adjusted or device notify user change cut-off or check RR or HR or both.Institute
It is proposed device can RR be more than the predefined limit (for example, to adult > 35, to pediatric patients > 50 etc.) Shi Tongzhi user check and
Correct HR is inputted, or can adjust automatically cut-off.In one embodiment, breathing detection algorithm is continuous using the ratio of HR and RR
It updates.
The device can preferably provide breathing trace based on impedance or calculate the scalable of this trace based on it
Determined when the interval of (gain or conversion factor or scalable coefficient) using the combination of cut off or HR/RR ratio or both or from
The gain of dynamic setting impedance signal.In one embodiment, the phase of (HR identified with such as filter is associated) heart signal
Size can be compared with the relative size of breath signal, generated when to show on the screen impedance trace (y-axis)
Scaling factor/gain of absolute value.The relative size of heart signal can be logged or by other means based on the often amount of fighting
Measurement estimate or 70cc or related to BSA, BMI or height etc. be assumed to average adult.
The given heart signal suitably filtered, the size of HR signal and RR signal or HR signal are relatively large with RR signal
The general reduction of tidal volume in small variation preferably instruction breathing trace, and can be used to trigger and small amount is optimized
The change of breathing detection algorithm.
The group of ratio (I/E ratio) of HR/RR cut-off or sucking duration and expiration duration or both can be used in the device
Close the diagnosis to indicate level of sedation or respiratory disorder.In one embodiment, refer in the duration of the extension platform at air-breathing end
Show calmness caused by class opium (referring to Fig. 6 A-C).In one embodiment, the duration of platform is used to adjust HR/RR cut-off.?
In one embodiment, breathing-respiratory intervals duration be defined as since end-tidal-end-tidal or exhale terminate with air-breathing it
Between interval.
The device be preferably able to by institute typing TV or MV measure (amount synchronous mode) with measured or typing HR and/or
Heart signal, which combines, to be used to help to adjust HR/RR filter cutoff, to better discriminate between RR and HR.In one embodiment, TV
Carry out typing from respirator, BiPAP, spirometer, pneumotachograph or another device with RR.If MV is from respirator
Carry out typing and RR from respirator to come typing and RR different from respirator RR, then adjust HR/RR filter or breathing detection calculated
Method.
If RR is reported as than by clinical or other measuring technique actual observations high, this is attributable to by device
When HR is lower than HR/RR cut-off or is just above but approaches cut-off and within intermediate zone (between passband and stopband).
If situation be in this way, if no matter with and without RR or HR external input, which can automatically select, prompts or receive letter
HR, to deviate intermediate zone far from HR, is effectively placed on new selection to select the filter with lower cut off by breath
Within the stopband of filter, to improve the precision of RR counting.
The MV predicted
In existing apparatus, the prediction MV (MV calculated of the simple formula based on Patient height, weight and gender is usedPRED) use
Make reference value, to provide the relative scalar for breathable properties compared with global average, and allows for known guide
Trend at any time.In the present apparatus, MVPREDIt can further be adjusted to consider the specific physiology of patient, dissection, form or open up
It flutters.In one embodiment of the device, compared with the sitting obese patient with similar BMI, the sportsman with high BMI will
With raising MVPRED.In one embodiment, decrease ability of the patient with chronic lung disease because of its lung exchange oxygen and CO2
And will there is the MV higher than the healthier patient of identical height, weight and genderPRED, thus increasing its " benchmark " breathing need to
It wants.
Alarm limit
Present apparatus uses the predefined mark of the prediction MV calculated of the function based on the size (height and weight) as patient
Quasi- alarm limit.It in one embodiment, is not using the standard alarm limit, alarm limit is to be based on following one or more certainly
It adapts to: patient disease state (thyroid gland, diabetes, COPD etc.), physician's assessment, clinical or Curing circumstance (ICU, family
Front yard, hyperbaric chamber, respirator use, BIPAP use, CPAP use, Gao Liudong oxygen, negative pressure ventilation, alternative air (such as high frequency or
Oscillator, ECMO etc.), additional physiological measurement (BP, HR, EtCO2, SpO2, fluid water equality) or external reference (CPAP, exhale
Haustorium, PFT test etc.).These adaptive alarm limit can be used to notify about deteriorating patient condition, but also with treatment
Method/treatment combines, to track the improvement and/or beneficial effect for the treatment of.
Following example shows the embodiment of the present invention, but should not be construed as limited the scope of the present invention.
Example
The present apparatus is compared with existing marketing apparatus
The present apparatus and Respiratory Motion, the ExSpiron 1Xi that Inc. (Waltham, MA) is marketed are compared
Compared with.Itd is proposed invention is also exhaled with nSpire Health, the Wright/Haloscale that Inc. (Longmont, CO) is marketed
Meter is inhaled to be compared.Because because of survey while the interference that two similar installations will cause comes from multiple devices without being likely to be obtained
Amount carries out the clinical research of the design substantially the same with the design executed on existing apparatus to mankind volunteer subjects,
So that every point of ventilation (MV), tidal volume (TV) and FDA from the present apparatus are removed monitoring spirometer (Wright/
Haloscale respirometer, nSpire Health Inc., Longmont, CO) it is compared.
The anticipated applications of Wright/Haloscale respirometer are: being suffered from during anaesthetizing with post-operative recovery by Critical Care
The measurement and monitoring of the level of pulmonary ventilation acquired by person.It measures expiration amount, and thus indicates whether to obtain enough ventilations, is
Open circuit or closed circuit or spontaneous respiration or mechanically ventilated patient.
Philips Intellivue monitor expects for health care professional whenever the physiology for needing to monitor patient
It is used when parameter.It is expected that the monitoring of multiple physiological parameters for adult, paediatrics and baby in health care facility, record and
Alarm.MP20, MP30, MP40 and MP 50 is it is also anticipated that in the status transmission in health care facility.ST Segment monitoring
It is only limited to adult patient.Percutaneous gas measurement (tcpO2/tcpCO2) is only limited to infant patients.(note: Philips monitoring
Device can monitor many physiologic variables.For the ease of this test, only respiratory rate function is applicatory.)
The present apparatus uses biological impedance, and calculates volume and respiratory rate value.Wright/Haloscale respirometer uses
In-line turbine carrys out measuring flow, and calculates volume and flow.Philips Intellivue monitor uses impedance measurement
In measurement respiratory rate.
The precision of measurement can be determined by clinical research, use the present apparatus and Wright/Haloscale respirometer simultaneously
Measure the ventilation of patient.Stopwatch is used to determine practical respiratory rate.The research is clinical trial, because biological impedance must be
It is carried out in Human in Vivo.
Number is it was demonstrated that volume and the present apparatus show value of rate are equivalent to volume and the Wright/Haloscale of flow rate is exhaled
Meter show value is inhaled, without the calibration to spirometer.The electrical security of present apparatus biological impedance is hindered with using biology
The existing apparatus of anti-measurement is consistent, and meets electrical safety standards.
Clinical performance test:
Clinical research is compared measurement while coming from the present apparatus with basic monitoring and Wright/Haloscale respirometer.
(respiratory rate is calculated using stopwatch.) 20 subjects represent the large-scale estimated patient for participating in research.(the range of age: 22-
80, BMI ranges: 18.7-41.8, wherein 9 women, 11 males.) research be related to two phases of each subject, wherein applying
Electrode and each subject execute the initial period of 20 breath tests.Tidal volume, every point of ventilation and respiratory rate pass through the present apparatus
It is measured simultaneously with Wright respirometer.Each subject returning for 24 hours after the first phase, wherein original electrodes are attached always
Even.Execute second group of 20 breath test.
Result of study is shown in table 1:
Table 1
As a result the clinically relevant precision to 24 hour period is indicated.Comparison and non-clinical and clinical trial based on anticipated applications
As a result, the present apparatus is basic in terms of the anticipated applications of the present apparatus and Wright/Haloscale respirometer, safety and efficiency
Quite.
Exemplary device
Fig. 1 shows the embodiment of preferred embodiment 100 of the invention.Preferably, device 100 includes shell 105 and touch screen 110.
Although showing touch screen, the input unit (such as keyboard, mouse, microphone) of other forms can be used to enter information into device
In 100.Fig. 2 is the rearview of device 100.Device 100 may also include input port 115A-C, power connector 120 and electrode
Folder 125.Device 100 may also include the sense of hearing or visual warning system (such as loudspeaker or lamp).Device 100 can be by wired
Connect and/or be connected wirelessly to local area network or wide area network.
Although showing three port 115A-C, device 100 may include any amount of port.Preferably, port
115A-C is suitably attached to peripheral unit (such as respirator, EKG machine, spirometer and other medical devices) and sensing
Device information and/or is controlled it from wherein receiving.Port 115A-B all can be same type port or can be with
It is different types of port (such as USB port, proprietary port, serial or parallel port, FireWire port port and ethernet port).Example
Such as, device 100 can be suitably attached to cable 330 shown in Fig. 3.Cable 330 be preferably suitable for by piece group 440 (shown in Fig. 4) with
Device 110 is coupled, and sends signal from/to piece group 440.Cable 330 can be the proprietary cable with proprietary connector,
Or it can be Universal automatic cable (such as USB cable).In some embodiments, piece group 440 can be with 100 channel radio of device
Letter.Fig. 5 shows the preferred placement of the piece group 440 on trunk.The other configurations of piece group 440 and placement are also possible.
Fig. 6 A-E shows the screenshot capture of the graphic user interface (GUI) of device 100.Such as in Fig. 6 A-C it can be seen that
GUI can show patient respiratory 650, patient MV and prediction MV 655 and association diagram 657, patient TV 660 and association diagram 663
And the chart of patient RR 665 and association diagram 667.Several optional icon 670A-D also may be present.In addition, each in GUI
Kind display can be it is selectable, to provide more information.GUI can be customized.For example, different data can be in GUI
It is shown in interior different location, more data can be added to GUI or delete from GUI.In addition, more or less icons can be
It is shown on GUI.
Example patient shown in Fig. 6 A is the patient that the class opium not breathed on it influences.Example patient shown in Fig. 6 B
It is the patient that its breathing reaches balance because of class opium.When example patient shown in Fig. 6 C is that it is breathed due to class opium to extending
Between the period reach the patient of balance.In addition, Fig. 6 C shows the heart signal for being superimposed on breath signal.
Fig. 6 D shows the example of the menu in GUI, shown menu show for be arranged because alarm caused by MV/TV/RR with
And the selection in the period of breathing is not detected.These selections can be arranged by nursing staff based on monitored patient, Huo Zheyou
Device is based on received data and is arranged automatically.In addition, as illustrated in fig. 6e, menu has for customization as disclosed herein to be arranged
The option of RR-HR cut-off.
The other embodiment of the present invention and purposes will be that those skilled in the art passes through thinking this specification and implementation
What invention disclosed herein was clear from.It is cited herein all referring to document (including whole publication, U.S. and outer
State's patent and patent application) it is specifically completely combined by reference.Term "comprising" is estimated in the case of being used to include
Term " consist of " and " substantially by ... form ".In addition, term "comprising", " comprising " are not intended to and are limited.In advance
Meter this specification and example are considered to be only exemplary, and wherein the true scope and spirit of the invention passes through following following claims
Indicated by book.
Claims (23)
1. a kind of respiration monitoring system, comprising:
Computing device, wherein the computing device includes:
Processor；
At least one graphic user interface (GUI) communicated with the processor；And
At least one sensor input communicated with the processor；And
Electrode slice group is suitble to be coupled to patient, wherein the electrode slice group can be coupled to the sensor input, receive from institute
It states the electric signal of computing device and bioimpedance signal is detected by the trunk of the patient；
Wherein the processor determines the percentage of every point of ventilation (MV), predicted MV based on detected bioimpedance signal in real time
Than, moisture ventilation (TV), the percentage of predicted TV, respiratory rate (RR) and predicted RR percentage, without to given value
Calibration or during normal ventilation collected benchmark and be not necessarily to patient cooperation；And
Wherein the GUI exports every point of ventilation (MV), the percentage of predicted MV, moisture ventilation (TV), predicted TV in real time
Percentage, respiratory rate (RR) and predicted RR percentage in identified one or more.
2. respiration monitoring system as described in claim 1, wherein the system provides hyperventilation, normal ventilation and ventilation
The instruction of at least one of deficiency.
3. respiration monitoring system as described in claim 1, wherein the system is mentioned based on respiration inhibition caused by class opium
For at least one hypoventilation, the variation of breath signal waveform, the variation of air-breathing expiration ratio and the development of flateau instruction.
4. respiration monitoring system as described in claim 1, wherein the computing device is suitble to by patient demographics typing
The continuous measurement of ventilation is provided within one minute into described device.
5. respiration monitoring system as claimed in claim 4, wherein the demographics be the height of the patient, weight and
At least one of gender.
6. respiration monitoring system as claimed in claim 4, wherein the computing device is adapted to provide for the continuous measurement of ventilation,
Without the benchmark of patient's particular calibration or the patient in eupnea to respirator.
7. respiration monitoring system as described in claim 1, wherein the computing device is suitble in the attaching electrodes described in
The continuous measurement of ventilation is provided when device immediately, without typing consensus data.
8. respiration monitoring system as described in claim 1, wherein do not require patient cooperation or to the breathing of the patient
Control.
9. respiration monitoring system as described in claim 1, wherein do not require described device to known breath device, spirometer
Or the calibration of pneumotachograph reading.
10. respiration monitoring system as described in claim 1, wherein the computing device further includes HR-RR cut-off filter.
11. respiration monitoring system as claimed in claim 10, wherein the HR-RR cut-off filter is cut based on target heart rate
Stop is filtered breathing and heart signal.
12. respiration monitoring system as claimed in claim 10, wherein the heart rate cut off is per minute 30,40,50 or 60
Jump one of (bpm).
13. respiration monitoring system as claimed in claim 11, wherein the heart rate cut off is based on patient demographics, MV
Or at least one of the percentage of prediction MV and shallow fast breathing index.
14. respiration monitoring system as claimed in claim 11, wherein the heart rate cut off is manually entered, or by described
Computing device is automatically updated.
15. respiration monitoring system as claimed in claim 10, wherein the HR-RR cut-off filter provides the impedance letter
Number the measurement of gain, the scaling factor of absolute value of the impedance trace shown on the GUI, tidal volume reduced instruction,
At least one of instruction and the diagnosis of respiratory disease of level of sedation.
16. respiration monitoring system as described in claim 1 further includes at least one sense of hearing or visual alarm.
17. respiration monitoring system as claimed in claim 16, wherein at least one described sense of hearing or visual alarm are based on patient
At least one of morbid state, physician's assessment, clinical or Curing circumstance, physiological measurements or external reference are arranged.
18. respiration monitoring system as claimed in claim 15, wherein at least one described sense of hearing or visual alarm are adaptive
's.
19. respiration monitoring system as described in claim 1, wherein prediction height, weight and the gender of the MV based on patient
To calculate.
20. respiration monitoring system as claimed in claim 19, wherein prediction MV calculating further include the specific physiology of patient,
At least one of dissection, form or topology.
21. respiration monitoring system as described in claim 1, wherein the system be suitable for wake, it is unconscious, there is meaning
Know, the patient of one of them uses after intubation, respiratory distress or calmness on terminal stage, respirator.
22. respiration monitoring system as described in claim 1, wherein the system is noninvasive.
23. respiration monitoring system as described in claim 1 further includes that the electrode slice group is coupled to the computing device
Patient's cable, wherein patient's cable is suitble to transmit high-frequency current to the patient via the electrode slice group.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310486432.7A CN116584922A (en) | 2016-08-01 | 2017-08-01 | Advanced respiratory monitor and system |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369583P | 2016-08-01 | 2016-08-01 | |
| US62/369583 | 2016-08-01 | ||
| PCT/US2017/044806 WO2018026760A1 (en) | 2016-08-01 | 2017-08-01 | Advanced respiratory monitor and system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310486432.7A Division CN116584922A (en) | 2016-08-01 | 2017-08-01 | Advanced respiratory monitor and system |
Publications (1)
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|---|---|
| CN109963497A true CN109963497A (en) | 2019-07-02 |
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ID=61073548
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| CN202310486432.7A Pending CN116584922A (en) | 2016-08-01 | 2017-08-01 | Advanced respiratory monitor and system |
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| CN202310486432.7A Pending CN116584922A (en) | 2016-08-01 | 2017-08-01 | Advanced respiratory monitor and system |
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| EP (1) | EP3474738A4 (en) |
| JP (2) | JP2019527117A (en) |
| KR (1) | KR20190032577A (en) |
| CN (2) | CN109963497A (en) |
| AU (2) | AU2017306133A1 (en) |
| CA (1) | CA3032574A1 (en) |
| MX (1) | MX2019001397A (en) |
| WO (1) | WO2018026760A1 (en) |
| ZA (1) | ZA201900667B (en) |
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| CN114743348B (en) * | 2022-05-07 | 2023-06-27 | 广州蓝仕威克医疗科技有限公司 | Multifunctional monitoring device for intelligently judging excessive ventilation based on electrocardiosignals |
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- 2017-08-01 AU AU2017306133A patent/AU2017306133A1/en not_active Abandoned
- 2017-08-01 KR KR1020197006189A patent/KR20190032577A/en not_active Application Discontinuation
- 2017-08-01 CA CA3032574A patent/CA3032574A1/en active Pending
- 2017-08-01 CN CN201780053679.2A patent/CN109963497A/en active Pending
- 2017-08-01 EP EP17837502.8A patent/EP3474738A4/en not_active Withdrawn
- 2017-08-01 CN CN202310486432.7A patent/CN116584922A/en active Pending
- 2017-08-01 WO PCT/US2017/044806 patent/WO2018026760A1/en unknown
- 2017-08-01 JP JP2019505221A patent/JP2019527117A/en active Pending
-
2019
- 2019-01-31 ZA ZA201900667A patent/ZA201900667B/en unknown
-
2022
- 2022-06-30 JP JP2022105576A patent/JP2022136344A/en active Pending
- 2022-08-03 AU AU2022211837A patent/AU2022211837A1/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CN116584922A (en) | 2023-08-15 |
| WO2018026760A1 (en) | 2018-02-08 |
| KR20190032577A (en) | 2019-03-27 |
| ZA201900667B (en) | 2020-11-25 |
| AU2017306133A1 (en) | 2019-02-07 |
| JP2019527117A (en) | 2019-09-26 |
| AU2022211837A1 (en) | 2022-08-25 |
| JP2022136344A (en) | 2022-09-16 |
| EP3474738A4 (en) | 2020-02-26 |
| MX2019001397A (en) | 2019-06-12 |
| EP3474738A1 (en) | 2019-05-01 |
| CA3032574A1 (en) | 2018-02-08 |
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