CN109925532A - A kind of compound hemostatic prevents adhesion dressing and its preparation method and application - Google Patents
A kind of compound hemostatic prevents adhesion dressing and its preparation method and application Download PDFInfo
- Publication number
- CN109925532A CN109925532A CN201910197548.2A CN201910197548A CN109925532A CN 109925532 A CN109925532 A CN 109925532A CN 201910197548 A CN201910197548 A CN 201910197548A CN 109925532 A CN109925532 A CN 109925532A
- Authority
- CN
- China
- Prior art keywords
- dressing
- cotton
- cotton fabric
- ethanol water
- mixed solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
It prevents adhesion dressing and its preparation method and application the present invention relates to a kind of compound hemostatic.The dressing is to obtain the mixture of chitosan particle and carboxymethylcellulose sodium solution blade coating on carboxy methylation cotton fabric.This method comprises: pretreated knitted cotton is carried out basification, then carries out etherification process and obtain carboxy methylation cotton fabric；It disperses chitosan particle in carboxymethylcellulose sodium solution and obtains mixed solution, and scratch on obtained carboxy methylation cotton fabric, drying.The dressing has good water imbibition, excellent anthemorrhagic performance and can gelatinization performance.
Description
Technical field
The invention belongs to bleeding-stopping dressing and its preparation and application field, in particular to a kind of compound hemostatic prevent adhesion dressing and
Preparation method and application.
Background technique
Haemorrhagic shock is the cause of death common in medical trauma, traffic accident and Wounded in Hostile Action.Uncontrollable mistake
Blood leads to the died of wounds in 30% or more the whole world.Existing dressing is easy to stick together with wound, easily makes when removed to wound
At secondary injury, increase patient's pain.Therefore, effective bleeding stopping and adherence preventing dressing is developed to be of great significance.
Chitosan is deacetylated from chitin, it is nontoxic and have good biocompatibility, biodegradable,
Antibiotic property, hemostasis promote a variety of physiological activities such as wound healing.Sodium carboxymethylcellulose is that a kind of histocompatbility is good,
It is biodegradable, physicochemical property it is stable and can effective prevention of postoperative adhesion polysaccharide compound.
Traditional hemostatic material such as cotton gauze dressing has water imbibition, the advantage of good permeability, but there are haemostatic effects
Difference, it is big to the irritation of tissue, and the defect easily with wound adhesion.In recent years, have and select oxycellulose, carboxymethyl chitosan
The materials such as sugar, carboxymethyl cellulose make the product of hemostatic gauze.Chinese patent CN103120802A discloses " soluble hemostatic gauze
Cloth and preparation method thereof " obtains soluble stanching gauze using carboxymethylated solvent-spun cellulose fibre.In addition, China is specially
Sharp CN101491688A, CN106474525A disclose stanch fibre fabric and preparation method thereof.However, the hemostasis of above-mentioned patent
Material mostly ingredient is single, and bleeding stopping and adherence preventing is ineffective.
Ideal dressing should have the following characteristics that (1) must keep the cleaning of wound location skin and moisten, and be convenient for wound
Healing.(2) there is the ability for absorbing liquid secretion thing.(3) there is good biocompatibility, it is easy to use, it is light-weight, stablize
And the advantages that cheap.
Summary of the invention
It prevents adhesion and dressing and preparation method thereof and answers technical problem to be solved by the invention is to provide a kind of compound hemostatic
With to overcome bleeding-stopping dressing haemostatic effect in the prior art and the bad defect of preventing adhesiving effect.
The present invention is low with skin irritation, flexible, breathable simultaneously with good water absorbing capacity cotton fabric be substrate, pass through by
Its carboxymethylation method obtains the modified cotton fabric with gelling performance, then by it in conjunction with sodium carboxymethylcellulose, chitosan
To improve modified cotton fabric hemostasis, the bad defect of preventing adhesiving effect.The compound carboxy methylation of chitosan, sodium carboxymethylcellulose
Cotton fabric has broad application prospects in terms of effectively stopping blooding and preventing adhesion, therefore can be used as novel wound dressing and be applied to life
Object medicine.
It prevents adhesion dressing the present invention provides a kind of compound hemostatic, the dressing is by chitosan particle and carboxymethyl cellulose
What the mixture blade coating of plain sodium solution obtained on carboxy methylation cotton fabric.
It prevents adhesion the method for dressing the present invention also provides a kind of compound hemostatic, comprising:
(1) pretreated knitted cotton is subjected to basification, then carries out etherification process, obtains carboxymethylated cotton and knit
Object；
(2) it adds chitosan into the carboxymethylcellulose sodium solution of 1-5g/L, stirs evenly, obtain mixed solution,
Wherein the additional amount of chitosan is 1-6g/L；
(3) mixed solution blade coating in step (2) on carboxy methylation cotton fabric, is dried in step (1), obtains compound stop
Prevention and cure of schistosomiasis adhesion dressing, wherein the dosage of mixed solution is 0.5-1.5mL/cm2。
The pretreatment of knitted cotton includes: knitted cotton to be immersed in sodium hydroxide and isomerous tridecanol gathers in the step (1)
In the mixed solution of ethylene oxide ether 1305,85-100 DEG C of reaction 30-45min is cleaned, drying, and wherein sodium hydroxide concentration is 2-
10g/L, 1305 dosage of isomerous tridecanol polyoxyethylene ether are 2-10g/L, bath raio 1:30-1:50.
The cleaning is with a large amount of deionized waters；Drying temperature is 60-80 DEG C.
Basification includes: that pretreated knitted cotton is immersed in 25-45g/L sodium hydroxide in the step (1)
In ethanol water, 25-40min is reacted at 5-15 DEG C, wherein bath raio is 1:20-1:30.
Etherification process includes: that the ethanol water of 10-50g/L chloroacetic acid is added at alkalization in the step (1)
It manages in reaction system, is uniformly mixed, 2.5-3.5h is reacted at 50-70 DEG C, adjust pH to neutrality, wash, drying a, wherein chloroethene
The ethanol water and basification reaction system volume ratio of acid are 2.5:5-3:5.
The ethanol water mass fraction is 85wt%.
The hydrochloric acid solution for adjusting pH and using 0.5mol/L；Washing is washed 2-4 times with ethanol water (85wt%).
The drying temperature is 60-80 DEG C.
Drying in the step (3) are as follows: dry 10min in 100-110 DEG C of baking oven, take out and in 20-30 DEG C of drying.
It prevents adhesion the application of dressing the present invention also provides a kind of compound hemostatic.
Chitosan is not soluble in water, and carboxy methylation cotton fabric can be hardened after the processing of water and become fragile.The present invention utilizes carboxylic
Chitosan particle is fixed on carboxy methylation cotton fabric by methylcellulose sodium water solution as carrier.Sodium carboxymethylcellulose
Can with carboxy methylation cotton fabric by non-covalent bond in conjunction with, disperse carboxymethylcellulose sodium solution for chitosan particle and scrape
It is coated in carboxy methylation surface of cotton fabric, chitosan particles may be implemented in the fixation of fabric surface.In addition, sodium carboxymethylcellulose
Solution is more sticky, will not completely penetrate the inside of cotton fabric, and maximization reduces moisture in carboxy methylation cotton fabric
Portion's structural damage.It is good to prepare resulting dressing water imbibition, anthemorrhagic performance, there is gelatinization performance.
Beneficial effect
(1) base material is cotton fabric in the present invention, and material is easy to get, cheap；Sodium carboxymethylcellulose, chitosan is all
With good biocompatibility, have no toxic side effect；The compound hemostatic of preparation prevent adhesion dressing have it is easy to use, it is light-weight,
Flexibility is good, the advantages that can cutting.
(2) dressing of the present invention has good water imbibition, the liquid secretion thing of wound can be absorbed, and can be used as physics screen
Barrier stops the injuries of the substances to wound such as extraneous dust, bacterium.
(3) dressing of the present invention has excellent anthemorrhagic performance.Dressing will form gelling material after contacting blood, block blood
Pipe, slows down bleeding；Chitosan can release under blood effect, play its anastalsis.
(4) dressing of the present invention it is standby can gelatinization performance, the cleaning of wound location skin and wet can be kept, convenient for wound
Mouth healing, is easily removed, will not cause secondary injury to wound.
Detailed description of the invention
Fig. 1 is that compound hemostatic prevents adhesion the scanning electron microscope diagram of dressing in embodiment 1.
Fig. 2 is the scanning electron microscope diagram of carboxy methylation cotton fabric in embodiment 1.
Fig. 3 is that aqueous gelled figure is met in the compound hemostatic dressing that prevents adhesion in embodiment 2.
Fig. 4 is that rat lung Hemorrhage Model (a) and compound hemostatic prevent adhesion (b) figure after dressing hemostasis in embodiment 4, wherein
(a) in white wire be the edge of a knife, (b) in white wire be clot and gel.
Fig. 5 is that rat femoral Hemorrhage Model (a) and compound hemostatic prevent adhesion (b) figure after dressing hemostasis in embodiment 4,
In in (a) white wire be the edge of a knife, (b) in white wire be clot and gel.
Specific embodiment
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, those skilled in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
Isomerous tridecanol polyoxyethylene ether 1305 derives from BASF AG, remaining reagent purchase is tried from Chinese medicines group chemistry
Agent Co., Ltd, knitted cotton (grammes per square metre: 150g/m2) derive from from Shandong Lu Tai Textile Co., Ltd..
Embodiment 1
(1) mixed solution of 2g/L sodium hydroxide and 2g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and will knitting
Cotton is immersed in mixed solution, 90 DEG C at a temperature of react 30min, bath raio 1:30.By a large amount of deionizations of gained fabric
Water cleans up, and it is dried in 60-80 DEG C of baking oven.
(2) processed knitted cotton in step (1) is immersed in the ethanol water (85wt%) of 40g/L sodium hydroxide
In, 10 DEG C at a temperature of react 30min, bath raio 1:30.
(3) ethanol water (85wt%) of a certain amount of 20g/L chloroacetic acid is added to the reaction system of step (2)
In, be sufficiently mixed uniformly, 70 DEG C at a temperature of react 3h.The ethanol water (85wt%) and step of the chloroacetic acid of addition
(2) volume ratio of the ethanol water (85wt%) of sodium hydroxide is 3:5 in.PH is adjusted into the hydrochloric acid solution of 0.5mol/L
Property, then washed 2-4 times with ethanol water (85wt%).Later, gained fabric is dried in 60-80 DEG C of baking oven and obtains carboxylic first
Base cotton fabric.
(4) a certain amount of chitosan is added in the carboxymethylcellulose sodium solution of 2g/L, is stirred.Shell is poly-
The additional amount of sugar is 2g/L.
(5) a certain amount of step (4) resulting mixture scraper is scratched in the resulting carboxy methylation cotton fabric of step (3)
On (4cm × 4cm).The dosage of step (4) resulting mixture is 0.9mL/cm2.By gained compound in 100-110 DEG C of baking oven
Middle baking 10min, takes out and is drying to obtain compound hemostatic in 20-30 DEG C and prevent adhesion dressing.Gained compound hemostatic prevents adhesion dressing
Unit area water absorption is 1.33 times of raw cotton.
Fig. 1 shows: chitosan and sodium carboxymethylcellulose are successfully organized on carboxymethyl cotton fabric.
Fig. 2 shows: after carboxy methylation is handled, surface of cotton fabric occurs damaged.
Embodiment 2
(1) mixed solution of 3g/L sodium hydroxide and 3g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and will knitting
Cotton is immersed in mixed solution, 95 DEG C at a temperature of react 45min, bath raio 1:40.By a large amount of deionizations of gained fabric
Water cleans up, and it is dried in 60-80 DEG C of baking oven.
(2) processed knitted cotton in step (1) is immersed in the ethanol water (85wt%) of 35g/L sodium hydroxide
In, 15 DEG C at a temperature of react 40min, bath raio 1:30.
(3) ethanol water (85wt%) of a certain amount of 30g/L chloroacetic acid is added to the reaction system of step (2)
In, be sufficiently mixed uniformly, 65 DEG C at a temperature of react 3.5h.The ethanol water (85wt%) and step of the chloroacetic acid of addition
Suddenly the volume ratio of the ethanol water (85wt%) of sodium hydroxide is 2.5:5 in (2).PH is adjusted with the hydrochloric acid solution of 0.5mol/L
It is washed 2-4 times to neutrality, then with ethanol water (85wt%).Later, gained fabric is dried in 60-80 DEG C of baking oven and is obtained
Carboxy methylation cotton fabric.
(4) a certain amount of chitosan is added in the carboxymethylcellulose sodium solution of 2g/L, is stirred.Shell is poly-
The additional amount of sugar is 3g/L.
(5) a certain amount of step (4) resulting mixture scraper is scratched in the resulting carboxy methylation cotton fabric of step (3)
On (4cm × 4cm).The dosage of step (4) resulting mixture is 0.7mL/cm2.By gained compound in 100-110 DEG C of baking oven
Middle baking 10min, takes out and is drying to obtain compound hemostatic in 20-30 DEG C and prevent adhesion dressing.Gained compound hemostatic prevents adhesion dressing
Unit area water absorption is 1.35 times of raw cotton.
Fig. 3 shows: modified carboxy methylation cotton fabric have can gelation performance, meet it is aqueous gelled.
Embodiment 3
(1) mixed solution of 8g/L sodium hydroxide and 2g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and will knitting
Cotton is immersed in mixed solution, 85 DEG C at a temperature of react 30min, bath raio 1:30.By a large amount of deionizations of gained fabric
Water cleans up, and it is dried in 60-80 DEG C of baking oven.
(2) processed knitted cotton in step (1) is immersed in the ethanol water (85wt%) of 42g/L sodium hydroxide
In, 13 DEG C at a temperature of react 30min, bath raio 1:30.
(3) ethanol water (85wt%) of a certain amount of 34g/L chloroacetic acid is added to the reaction system of step (2)
In, be sufficiently mixed uniformly, 65 DEG C at a temperature of react 3h.The ethanol water (85wt%) and step of the chloroacetic acid of addition
(2) volume ratio of the ethanol water (85wt%) of sodium hydroxide is 3:5 in.PH is adjusted into the hydrochloric acid solution of 0.5mol/L
Property, then washed 2-4 times with ethanol water (85wt%).Later, gained fabric is dried in 60-80 DEG C of baking oven and obtains carboxylic first
Base cotton fabric.
(4) a certain amount of chitosan is added in the carboxymethylcellulose sodium solution of 3g/L, is stirred.Shell is poly-
The additional amount of sugar is 4.5g/L.
(5) a certain amount of step (4) resulting mixture scraper is scratched in the resulting carboxy methylation cotton fabric of step (3)
On (4cm × 4cm).The dosage of step (4) resulting mixture is 1.0mL/cm2.By gained compound in 100-110 DEG C of baking oven
Middle baking 10min, takes out and is drying to obtain compound hemostatic in 20-30 DEG C and prevent adhesion dressing.Gained compound hemostatic prevents adhesion dressing
Unit area water absorption is 1.40 times of raw cotton.
Embodiment 4
(1) mixed solution of 10g/L sodium hydroxide and 3g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and will knitting
Cotton is immersed in mixed solution, 85 DEG C at a temperature of react 30min, bath raio 1:30.By a large amount of deionizations of gained fabric
Water cleans up, and it is dried in 60-80 DEG C of baking oven.
(2) processed knitted cotton in step (1) is immersed in the ethanol water (85wt%) of 45g/L sodium hydroxide
In, 15 DEG C at a temperature of react 30min, bath raio 1:25.
(3) ethanol water (85wt%) of a certain amount of 34g/L chloroacetic acid is added to the reaction system of step (2)
In, be sufficiently mixed uniformly, 60 DEG C at a temperature of react 2.5h.The ethanol water (85wt%) and step of the chloroacetic acid of addition
Suddenly the volume ratio of the ethanol water (85wt%) of sodium hydroxide is 2.7:5 in (2).PH is adjusted with the hydrochloric acid solution of 0.5mol/L
It is washed 2-4 times to neutrality, then with ethanol water (85wt%).Later, gained fabric is dried in 60-80 DEG C of baking oven and is obtained
Carboxy methylation cotton fabric.
(4) a certain amount of chitosan is added in the carboxymethylcellulose sodium solution of 1g/L, is stirred.Shell is poly-
The additional amount of sugar is 5g/L.
(5) a certain amount of step (4) resulting mixture scraper is scratched in the resulting carboxy methylation cotton fabric of step (3)
On (4cm × 4cm).The dosage of step (4) resulting mixture is 1mL/cm2.By gained compound in 100-110 DEG C of baking oven
10min is dried, takes out and is drying to obtain compound hemostatic in 20-30 DEG C and prevent adhesion dressing.Gained compound hemostatic prevents adhesion the list of dressing
Plane product water absorption is 1.39 times of raw cotton.
Fig. 4 rat lung Hemorrhage Model prevents adhesion after dressing stops blooding with compound hemostatic schemes, and is the edge of a knife at straight line, circled is
Clot and gel.Illustrate that dressing can have an effect to form clot and gel with blood, and block blood outlet, to effectively stop blooding.
Fig. 5 rat femoral Hemorrhage Model prevents adhesion after dressing stops blooding with compound hemostatic schemes, and is the edge of a knife, circled at straight line
For clot and gel.Illustrate that dressing can have an effect to form clot and gel with blood, and blocks blood outlet to effectively stop blooding.
Comparative example 1
(1) mixed solution of 2g/L sodium hydroxide and 2g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and will knitting
Cotton is immersed in mixed solution, 90 DEG C at a temperature of react 30min, bath raio 1:30.By a large amount of deionizations of gained fabric
Water cleans up, and it is dried in 60-80 DEG C of baking oven.
(2) processed knitted cotton in step (1) is immersed in the ethanol water (85wt%) of 40g/L sodium hydroxide
In, 10 DEG C at a temperature of react 30min, bath raio 1:30.
(3) ethanol water (85wt%) of a certain amount of 20g/L chloroacetic acid is added to the reaction system of step (2)
In, be sufficiently mixed uniformly, 70 DEG C at a temperature of react 3h.The ethanol water (85wt%) and step of the chloroacetic acid of addition
(2) volume ratio of the ethanol water (85wt%) of sodium hydroxide is 3:5 in.PH is adjusted into the hydrochloric acid solution of 0.5mol/L
Property, then washed 2-4 times with ethanol water (85wt%).Later, gained fabric is dried in 60-80 DEG C of baking oven and obtains carboxylic first
Base cotton fabric.
(4) by a certain amount of deionized water processing on the resulting carboxy methylation cotton fabric of step (3) (4cm × 4cm), go from
The dosage of sub- water is 0.9mL/cm2。
(5) fabric obtained by step (4) is dried into 100-110 DEG C of baking oven 10min, take out and is drying to obtain in 20-30 DEG C
Compound hemostatic prevents adhesion dressing.The prevent adhesion unit area water absorption of dressing of gained compound hemostatic is 1.28 times of raw cotton.
Comparative example 2
The mixed solution of 2g/L sodium hydroxide and 2g/L isomerous tridecanol polyoxyethylene ether 1305 is prepared, and knitted cotton is soaked
Stain in mixed solution, 90 DEG C at a temperature of react 30min, bath raio 1:30.Gained fabric is clear with a large amount of deionized waters
Wash clean, and it is dried in 60-80 DEG C of baking oven and obtains pretreatment cotton fabric.
Embodiment sample and comparative example are subjected to pulmonary hemorrhage models and femoral artery Hemorrhage Model to 120 rats
Experiment, as a result as shown in following table (Tables 1 and 2).
The test of 1 rat lung Hemorrhage Model of table
As it can be seen from table 1 in rat lung Hemorrhage Model, the compound hemostatic prepared through the invention prevents adhesion dressing
With excellent anthemorrhagic performance.
The test of 2 rat femoral Hemorrhage Model of table
From table 2 it can be seen that the compound hemostatic prepared through the invention prevents adhesion deposited in rat femoral Hemorrhage Model
Material has excellent anthemorrhagic performance.
Claims (6)
- The dressing 1. a kind of compound hemostatic prevents adhesion, which is characterized in that the dressing is by chitosan particle and carboxymethyl cellulose What the mixture blade coating of sodium solution obtained on carboxy methylation cotton fabric.
- A kind of method of dressing 2. compound hemostatic prevents adhesion, comprising:(1) pretreated knitted cotton is subjected to basification, then carries out etherification process, obtains carboxy methylation cotton fabric；(2) it adds chitosan into the carboxymethylcellulose sodium solution of 1-5g/L, stirs evenly, obtain mixed solution, wherein The additional amount of chitosan is 1-6g/L；(3) mixed solution blade coating in step (2) on carboxy methylation cotton fabric, is dried in step (1), it is anti-obtains compound hemostatic Adhesion dressing, wherein the dosage of mixed solution is 0.5-1.5mL/cm2。
- 3. method according to claim 2, which is characterized in that the pretreatment of knitted cotton includes: that will be knitted in the step (1) Cotton is immersed in the mixed solution of sodium hydroxide and isomerous tridecanol polyoxyethylene ether 1305,85-100 DEG C of reaction 30-45min, Cleaning, drying, wherein sodium hydroxide concentration is 2-10g/L, and 1305 dosage of isomerous tridecanol polyoxyethylene ether is 2-10g/L, bath Than for 1:30-1:50.
- 4. method according to claim 2, which is characterized in that in the step (1) basification include: will be pretreated Knitted cotton is immersed in the ethanol water of 25-45g/L sodium hydroxide, and 25-40min is reacted at 5-15 DEG C, and wherein bath raio is 1: 20-1:30。
- 5. method according to claim 2, which is characterized in that etherification process includes: by 10-50g/L mono- in the step (1) Chloroacetic ethanol water is added in basification reaction system, is uniformly mixed, 2.5-3.5h is reacted at 50-70 DEG C, is adjusted PH is saved to neutrality, is washed, drying, wherein the ethanol water of chloroacetic acid and basification reaction system volume ratio are 2.5:5- 3:5。
- 6. a kind of application of dressing as described in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910197548.2A CN109925532A (en) | 2019-03-15 | 2019-03-15 | A kind of compound hemostatic prevents adhesion dressing and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910197548.2A CN109925532A (en) | 2019-03-15 | 2019-03-15 | A kind of compound hemostatic prevents adhesion dressing and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109925532A true CN109925532A (en) | 2019-06-25 |
Family
ID=66987197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910197548.2A Pending CN109925532A (en) | 2019-03-15 | 2019-03-15 | A kind of compound hemostatic prevents adhesion dressing and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109925532A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113481720A (en) * | 2021-05-14 | 2021-10-08 | 张毅 | Fabric with massage function and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0300625D0 (en) * | 2003-01-10 | 2003-02-12 | Bristol Myers Squibb Co | Wound dressing |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
| CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
| CN103041437A (en) * | 2012-12-25 | 2013-04-17 | 武汉纺织大学 | High-intensity high-hydroscopicity medical dressing containing carboxymethyl cellulose and preparation method thereof |
-
2019
- 2019-03-15 CN CN201910197548.2A patent/CN109925532A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0300625D0 (en) * | 2003-01-10 | 2003-02-12 | Bristol Myers Squibb Co | Wound dressing |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
| CN102137684A (en) * | 2008-04-25 | 2011-07-27 | 医疗行业产品有限公司 | Haemostatic material |
| CN103041437A (en) * | 2012-12-25 | 2013-04-17 | 武汉纺织大学 | High-intensity high-hydroscopicity medical dressing containing carboxymethyl cellulose and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 刘建平等: "《染整助剂》", 31 July 2009, 东华大学出版社 * |
| 唐有根: "《农副化工产品生产技术》", 31 July 1988, 中南工业大学出版社 * |
| 宋小平: "《纺织染整助剂生产工艺与技术》", 30 April 2017, 科学技术文献出版社 * |
| 常春雨等: "《新型纤维素、甲壳素水凝胶的构建、结构和性能》", 31 October 2015, 北京：知识产权出版社 * |
| 李万瑾: "《综合工业技术学》", 30 June 1988, 中国财政经济出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113481720A (en) * | 2021-05-14 | 2021-10-08 | 张毅 | Fabric with massage function and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2669557C2 (en) | Absorbing material | |
| US6998509B1 (en) | Wound care device | |
| US4405324A (en) | Absorbent cellulosic structures | |
| US4543410A (en) | Absorbent cellulosic base structures | |
| US20070104769A1 (en) | Bioabsorbable hemostatic gauze | |
| KR102324247B1 (en) | Degradable haemostat composition | |
| EP3119443B1 (en) | Wound dressing | |
| JPH08505790A (en) | Trauma bandage | |
| KR102342895B1 (en) | Degradable haemostat composition | |
| EP1951326A2 (en) | Bioabsorbable hemostatic gauze | |
| CN106110378A (en) | A kind of spray drying method prepares method and the application of degradable chitosan styptic powder | |
| CN112569400A (en) | Janus hemostatic dressing and preparation method thereof | |
| CN104208741A (en) | Chitosan based adhesive bandage | |
| CN109925532A (en) | A kind of compound hemostatic prevents adhesion dressing and its preparation method and application | |
| CN107177980B (en) | Contact wound dressing and preparation method thereof | |
| CN103174017B (en) | Sodium alginate oxide modified chitosan fiber and preparation method and application thereof | |
| US9144625B2 (en) | Cellulose ethylsulfonate-based absorbent material | |
| CN106963977A (en) | A kind of Breviscapinun/chitosan composite aquogel for suppressing cicatrization and preparation method thereof | |
| KR20180041980A (en) | Manufacturing method water-soluble hydrofiber and wound dressing using the water-soluble hydrofiber | |
| AU2015203676A1 (en) | Absorbent Material | |
| TWI498134B (en) | Composite dressing | |
| CN112569401A (en) | Degradable starch polysaccharide medical material and preparation method thereof | |
| CN102371003A (en) | Water-soluble fiber fabric wound dressing and preparation method thereof | |
| CN108404193A (en) | Bletilla tourniquet bandage product and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190625 |
|
| RJ01 | Rejection of invention patent application after publication |