CN109924336A - A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets - Google Patents
A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets Download PDFInfo
- Publication number
- CN109924336A CN109924336A CN201910269670.6A CN201910269670A CN109924336A CN 109924336 A CN109924336 A CN 109924336A CN 201910269670 A CN201910269670 A CN 201910269670A CN 109924336 A CN109924336 A CN 109924336A
- Authority
- CN
- China
- Prior art keywords
- zeaxanthin
- lutein ester
- preparation
- syrup
- soft sweets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Confectionery (AREA)
Abstract
The present invention discloses a kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets.Glue is made this method comprises: carragheen and pectin are dissolved in hot water；Glue is mixed with liquid syrup, solid content is heated between 65-70%, obtains mixed liquor A；Lutein ester, zeaxanthin, chitosan oligosaccharide are dissolved in ethanol water, spray-dried or fluidized bed drying obtains composite powder；Mixed liquor A and composite powder are mixed, adjust pH to soluble solid content between 3.5-4.5, is heated between 70-75%, pours in mould for candy, forms to get lutein ester zeaxanthin soft sweets.The lutein ester zeaxanthin soft sweets obtained by the method for the present invention, can be improved lutein ester, zeaxanthin absorptivity, while soft sweets Lutein ester and zeaxanthin good stability.
Description
Technical field
The invention belongs to field of food health care, are specifically related to a kind of preparation of high-selenium corn lutein ester zeaxanthin soft sweets
Method.
Background technique
With popularizing for the electronic products such as mobile phone, computer, Chinese number of netizen is growing: according in China Internet network information
The 43rd " China Internet network development shape of the heart (China Internet Network Information Center, CNNIC)
Condition statistical report " data show, by December, 2018, China's netizen's scale up to 8.29 hundred million, mobile phone users up to 8.17 hundred million,
Netizen is up to 98.6% by the ratio that mobile phone accesses internet.The electronic equipments such as mobile phone and computer, plate can reflect big
Measure blue light.Blue light refers to the visible light of wavelength 400-500nm, can penetrate cornea and crystalline lens and reach retina, generate high oxygen pressure,
High optically focused.And oxygen and photoactive substance content are high in retina, under the excitation of high energy blue light, can generate a large amount of free radical,
And a variety of redox reactions such as may cause peroxidatic reaction of lipid, generate a large amount of oxidation metabolites, at the same it is various from
Retinal pigment epithelium, which can be swallowed, by base causes retina to be damaged.Lutein (lutein), zeaxanthin
(zeaxanthin) it is two Carotenoids ingredients, intraocular multiple tissues is widely present in, particularly, in fovea centralis
And its peripheral region (macula retinae area) concentration highest (also known as the two is macular pigment), the region are that vision is the sharpest
Region keeps macula lutea health for keeping normal vision function most important.Experimental study shows lutein, zeaxanthin tool
" the blue light filtering " that has and anti-oxidation characteristics, can preferably protect retina.
Lutein, zeaxanthin are lipophilicity pigment, and absorptivity is lower under the hydrophilic environments such as human gastrointestinal tract.Mesh
The method of premise high lutein absorptivity mainly includes following manner: nanosizing reduces partial size and (it is yellow that Xanthin micro-capsule, leaf is such as made
Plain nano particle)；Promote the transmembrane transport of lutein ester (as used liposome technology).Patent " the stabilization water dispersion of lutein
Body and stable water can be dispersed dried powder and its preparation and applies (notification number CN1125145C) " it is described, lutein is dissolved in
In water mixed organic solvents, and using casein or caseinate as protective agent, solvent seasoning can be obtained into lutein water dispersion
Body (nano-scale particle).Patent " lutein-hydrogenated phospholipid liposome precursor and preparation method thereof (notification number CN101716144B) "
Using supercritical CO2The mixture that lutein and its hydrogenated phospholipid are dissolved in water and organic solvent is dried technology, obtains leaf Huang
Plain hydrogenated phospholipid liposome precursor.
Different modes have the effect of for the raising of absorptivity it is certain, but these methods adapt to product type not
Together, there is certain limitation thus in practical application.Soft sweets as a kind of food formulation characterized by matrix network structure,
Since soft sweets digestion process is slower, the nanosizing or liposomal of functional component can not play its advantage.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation methods of high-selenium corn lutein ester zeaxanthin soft sweets.
In order to achieve the above objectives, the present invention adopts the following technical solutions:
In a first aspect, the present invention provides a kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, this method packet
Include following steps:
(1) in parts by weight, 60-80 parts of carragheens and 10-20 parts of pectin are soluble in water, heating keeps it completely molten
Solution, obtains glue；The dosage of the water is 10-18 times of carragheen and pectin total weight；
The glue is mixed with 2100-5000 part liquid syrup in terms of solid concentration 75%, is heated at 90 DEG C or more
It is 65%-70% to solid content, obtains mixed liquor A；The liquid syrup is the combination of syrup or syrup and sugar cube；；
(2) in parts by weight, 5-20 parts of lutein esters, 1-10 parts of zeaxanthins and 5-10 parts of chitosan oligosaccharides are dissolved in
In ethanol water, then dry composite powder；The dosage of the ethanol solution is that lutein ester, zeaxanthin and shell are few
1-3 times of sugared total weight；
(3) composite powder of the mixed liquor A of step (1) and step (2) is mixed at 85-90 DEG C, adjusts pH to 3.5-
4.5, continue to be heated to soluble solid content to be 70%-75%, pours in mold, form.
It should be noted that in the above-mentioned methods, the execution sequence of step (1) and (2) is not limited, for example,
Step (1), step (2) can be executed sequentially, step (2) step (1) also can be executed sequentially, more alternatively, according to actual production
Condition, while carrying out step (1) and step (2).
In step (1), the heating temperature when present invention is to prepare glue is not limited, as long as making it completely dissolved i.e.
It can.In a specific embodiment of the invention, after carragheen and pectin being added to the water, 90 DEG C or more are heated to, keeps its complete
Fully dissolved.
Further, in step (1), the liquid syrup can using common glucide when the production soft sweets of this field and
Prepared by preparation method, for example, the syrup can be selected from glucose syrup, fructose syrup, the sorb that sugar content is 50%-80%
One or more of sugar alcohol, maltitol liquor；The sugar cube is in white granulated sugar, fructose, maltitol, antierythrite
It is one or more.Syrup or the liquid syrup that joined sugar cube are heated to certain temperature, such as 90 DEG C or more, stirring makes it sufficiently
Dissolution, then mixed with the glue.
Further, in step (2), the molecular weight of the chitosan oligosaccharide is less than 1000Da, is formed after dry positively charged
Lutein ester zeaxanthin chitosan oligosaccharide small molecule complexes.
Further, in step (2), the mass concentration of the ethanol water is 30%-50%.
Further, in step (2), the drying can use drying means commonly used in the art, including but unlimited
In spray drying or fluidized bed drying.
Further, in step (3), the acidity adjustments such as citric acid, lactic acid, malic acid are can be used in the reagent for adjusting pH value
Sour agent further first can be configured to aqueous solution by agent, be then added in mixed liquor after being heated to dissolution.
Further, described molding in step (3) method particularly includes: dry to water under the conditions of 40 DEG C -50 DEG C
Dividing content is 10-20%.
It is claimed to also belong to the present invention by lutein ester zeaxanthin soft sweets prepared by the above method for second aspect
Range.
Beneficial effects of the present invention:
The present invention provides a kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, utilizes: (1) carragheen and fruit
The colloid formed after glue compounding can be with slow release (phase in intestinal environment due to the particularity of its molecule cross-link network structure
Than in gelatin, pectin gel networks) the lutein ester zeaxanthin chitosan oligosaccharide small molecule complexes that wherein wrap up, so that in enteron aisle
Interior lutein ester zeaxanthin concentration is lower, and the lutein and zeaxanthin carrier on enterocyte can be improved with active transport to be inhaled
It receives, avoids high concentration threshold effect caused by quick release (after tablet, capsule disintegration)；(2) lutein ester after discharging is beautiful
The positive charge of cream-coloured mass shell oligosaccharide compound institute band and the negative electrical charge of enterocyte institute band attract each other, and make lutein ester corn
Yellow matter is rapidly achieved enterocyte, and lutein and zeaxanthin is promoted to absorb；(3) it after carragheen is compounded with pectin, improves
The pH of gel rubber system, while the positive charge of lutein ester zeaxanthin chitosan oligosaccharide compound makes colloid molecules crosslinking more tight
Close, comprehensive function improves functional component stability in colloid.To sum up factor, the lutein ester corn obtained by the method for the present invention
Yellow matter soft sweets, can make the absorptivity of lutein ester and zeaxanthin be significantly improved；Soft sweets Lutein ester and corn simultaneously
Yellow matter stability is also superior to common soft sweets.
Detailed description of the invention
Fig. 1 is parenteral to turn over model schematic.
Fig. 2 lutein ester transit dose-time plot.
Fig. 3 zeaxanthin transit dose-time plot.
Specific embodiment
The invention discloses a kind of preparation methods of high-selenium corn lutein ester zeaxanthin soft sweets.Those skilled in the art can
To use for reference present disclosure, it is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to this
It is it will be apparent that they are considered as being included in the present invention for the technical staff of field.Method and product of the invention is
Be described by preferred embodiment, related personnel obviously can not depart from the content of present invention, in spirit and scope to herein
The method is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.
For a further understanding of the present invention, below in conjunction with the embodiment of the present invention, to the technical side in the embodiment of the present invention
Case is clearly and completely described, it is clear that and described embodiments are only a part of the embodiments of the present invention, rather than all
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art institute without making creative work
The every other embodiment obtained, shall fall within the protection scope of the present invention.
Unless otherwise specified, reagent involved in the embodiment of the present invention is commercial product, can pass through business canal
Road purchase obtains.
Embodiment 1
A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, main prescription dosage are as follows: lutein ester 5g, it is beautiful
Cream-coloured matter 1g, carragheen 60g, pectin 12g, chitosan oligosaccharide 5g.
Specific preparation method:
(1) boil glue and stir off: weigh formula ratio carragheen 60g, pectin 12g and 5g potassium citrate respectively, be dissolved in 15 times it is pure
Change in water and heat and be sufficiently stirred for 90 DEG C or more, makes it completely dissolved, obtain glue, heat preservation for standby use；Take formula ratio white granulated sugar
(1000g), maltitol powder (320g) are dissolved in glucose syrup (1000g, 75%), D-sorbite (712g), and 90 DEG C of heating are filled
Stirring is divided to make it completely dissolved.Above-mentioned glue is mixed with liquid syrup, continues infusion to solid content between 65-70%,
Obtain mixed liquor A.
(2) prepared by composite powder: weighing lutein ester 5g, zeaxanthin 1.6g, chitosan oligosaccharide 5g respectively and is dissolved in 1 times 30%
In ethanol solution, after being completely dissolved, it is spray-dried to obtain composite powder, for use.Citric acid 18.75g separately is weighed, in 2 times of hot water
After interior dissolution completely, acid solution, heat preservation for standby use are obtained.
(3) it mixes and pours: composite powder is added in above-mentioned mixed liquor A, 85-90 DEG C after mixing evenly, is added
Acid solution, adjust pH to 4.0, continue to stir evenly, until soluble solid content for 70-75% between, pour in starch mold must
Sample.
(4) dry: sample to be placed in drying 36 hours in 45 DEG C of baking ovens, until water content is 20% hereinafter, up to lutein
Ester zeaxanthin soft sweets.
Embodiment 2
A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, main prescription dosage are as follows: lutein ester 20g,
Zeaxanthin 5g, carragheen 80g, pectin 15g, chitosan oligosaccharide 10g.
Specific preparation method:
(1) boil glue and stir off: weighing formula ratio carragheen 80g respectively, pectin 15g and 11g potassium citrate, be dissolved in 10 times it is pure
Change in water and heat and be sufficiently stirred for 90 DEG C or more, makes it completely dissolved, obtain glue, heat preservation for standby use；Take formula ratio maltitol
(2000g), antierythrite (640g) are dissolved in fruit glucose syrup (2500g, 75%), and 90 DEG C of heating, which are sufficiently stirred, makes it completely
Dissolution.Above-mentioned glue is mixed with liquid syrup, continuation infusion between 65-70%, obtains mixed liquor A to solid content.
(2) prepared by composite powder: weighing lutein ester 20g, zeaxanthin 5g, chitosan oligosaccharide 10g respectively and is dissolved in 3 times 50%
In ethanol solution, after being completely dissolved, it is spray-dried to obtain composite powder, for use.Lactic acid 39.5g separately is weighed, in molten in 2 times of hot water
After solution is complete, acid solution, heat preservation for standby use are obtained.
(3) it mixes and pours: composite powder is added in above-mentioned mixed liquor, 85-90 DEG C after mixing evenly, and acid is added
Liquid, adjust pH to 4.3, continue to stir evenly, until soluble solid content for 70-75% between, pour in starch mold obtain sample
Product.
(4) dry: sample to be placed in drying 36 hours in 45 DEG C of baking ovens, until water content is 20% hereinafter, up to lutein
Ester zeaxanthin soft sweets.
Embodiment 3
A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, main prescription dosage are as follows: lutein ester 10g,
Zeaxanthin 3g, carragheen 65g, pectin 20g, chitosan oligosaccharide 7g.
Specific preparation method:
(1) it boils glue and stirs off: weighing formula ratio carragheen 65g, pectin 20g and 7.4g potassium citrate respectively, be dissolved in 15 times
It heats and is sufficiently stirred for 90 DEG C or more in purified water, make it completely dissolved, obtain glue, heat preservation for standby use；Take formula ratio white granulated sugar
(1260g), antierythrite (500g) are dissolved in maltitol (2280g, 75%), and 90 DEG C of heating, which are sufficiently stirred, keeps it completely molten
Solution.Above-mentioned glue is mixed with liquid syrup, continuation infusion between 65-75%, obtains mixed liquor A to solid content.
(2) prepared by composite powder: weighing lutein ester 10g, zeaxanthin 3g, chitosan oligosaccharide 7g respectively and is dissolved in 2 times 40%
In ethanol solution, after being completely dissolved, fluidized bed drying obtains composite powder, for use.Malic acid 30g separately is weighed, in 2 times of hot water
After dissolution completely, acid solution, heat preservation for standby use are obtained.
(3) it mixes and pours: composite powder is added in above-mentioned mixed liquor A, 85-90 DEG C after mixing evenly, is added
Acid solution, adjust pH3.5, continue to stir evenly, until soluble solid content for 70-75% between, pour in starch mold obtain sample
Product.
(4) dry: sample to be placed in drying 36 hours in 45 DEG C of baking ovens, until water content is 20% hereinafter, up to lutein
Ester zeaxanthin soft sweets.
Comparative example 1
It is beautiful that referenced patent " Lutein ester soft candy and preparation method thereof (notification number CN102578346B) " carries out lutein ester
Cream-coloured matter gelatine gums preparation.
(1) it boils glue and stirs off: weighing gelatin 60g, be dissolved in 5 times of amount water, 70 DEG C of heating water baths obtain glue to being swollen completely
Liquid；It weighs white granulated sugar (1320g) to be dissolved in glucose syrup (1712g), 90 DEG C of heating are sufficiently stirred and make it completely dissolved, by syrup
Liquid temperature is down to 70 DEG C or so and is mixed with glue, until solid content is between 65-75%, heat preservation for standby use；
(2) functional component is deployed: weighing lutein ester 5g respectively, zeaxanthin 1.6g is dissolved in 0.5 times of corn oil, heat preservation
For use；Citric acid 10.75g is weighed, is dissolved in equivalent hot water, heat preservation for standby use；
(3) it mixes and pours: functional component mixed liquor being added in above-mentioned syrup glue mixed liquor, 70 DEG C of heating stirrings are equal
After even, be added acid solution, continue to stir evenly, until soluble solid content for 70-75% between, pour in starch mold obtain sample
Product.
(4) dry: sample to be placed in drying 48 hours in 45 DEG C of baking ovens, until water content is 20% hereinafter, up to lutein
Ester zeaxanthin gelatine gums sample.
Comparative example 2
It is beautiful that referenced patent " Lutein ester soft candy and preparation method thereof (notification number CN102578346B) " carries out lutein ester
Cream-coloured matter jelly work preparation.
(1) boil glue and stir off: weigh pectin 60g and white granulated sugar (100g) it is dry-mixed uniformly after, be dissolved in 7 times of amount water, heating
Completely to dissolution, glue is obtained；It weighs surplus white granulated sugar (1220g) to be dissolved in glucose syrup (1712g), heating, which is sufficiently stirred, to be made
It is completely dissolved, and liquid syrup is mixed with glue, until solid content is between 65-75%, heat preservation for standby use；
(2) functional component is deployed: weighing lutein ester 5g respectively, zeaxanthin 1.6g is dissolved in 0.5 times of corn oil, heat preservation
For use；Citric acid 18.75g is weighed, is dissolved in 2 times of calorimetric water, heat preservation for standby use；
(3) it mixes and pours: functional component mixed liquor being added in above-mentioned syrup glue mixed liquor, heating stirring is uniform
Afterwards, be added acid solution, continue to stir evenly, until soluble solid content for 70-75% between, pour in starch mold obtain sample
Product.
(4) dry: sample to be placed in drying 36 hours in 45 DEG C of baking ovens, until water content is 20% hereinafter, up to lutein
Ester zeaxanthin jelly work sample.
Comparative example 3
Lutein ester 5g, zeaxanthin 1.6g are weighed, after the progress such as cyclodextrin suitably embed, with starch, magnesium stearate
Equal materials through mixing, granulation, drying, whole grain, tabletting and etc. lutein ester zeaxanthin piece is made.
Comparative example 4
Lutein ester 5g, zeaxanthin 1.6g are weighed, after adding the substances such as appropriate corn oil, after mixing, homogeneous mix,
Lutein ester zeaxanthin soft capsule can be obtained through pill.
Test 1- verifies the method for the present invention and can be improved the absorption of lutein ester and zeaxanthin
This test is using parenteral overmolded type research lutein ester, the intestinal absorption characteristic of zeaxanthin.Small intestine is most of mouths
The major absorption site of formulation is tested with external Intestinal absorption model, can directly embody enterocyte for functional component
Absorbing state.
Model preparation method: fresh processing pig duodenum 10cm is taken, simulated intestinal fluid (i.e. phosphate-buffered is immediately put into
Liquid, contains pancreatin, and pH6.8 is prepared referring to " Chinese Pharmacopoeia " 2015 editions IV general rules 8004) in rinse, until there is no content
Logistics goes out.Intestinal tube one end is ligatured in silicon rubber tube, carefully inverts intestinal tube, manually intestinal juice ligatures the other end after rinsing,
It is allowed to form cryptomere intestinal tube.It to the intracapsular injection 5mL blank simulated intestinal fluid of intestines, places it in the beaker containing simulated intestinal fluid, adjusts
Temperature is 37 DEG C of constant temperature, and 95%CO is passed through into beaker2+ 5%O2, 5min is balanced, for use.It keeps during the whole test process
37 DEG C of constant temperature and 95%CO2+ 5%O2Gaseous environment.The device figure of the model is as shown in Figure 1.
Test process: using according to sample prepared by embodiment 1, embodiment 2, embodiment 3 as embodiment sample (lutein
Ester, zeaxanthin, which feed intake, is respectively as follows: 4mg/, 1.2mg/；8mg/, 2mg/；6mg/, 1.8mg/), with comparative example
Lutein ester zeaxanthin gelatine gums (gelatin matrix), lutein ester zeaxanthin jelly work (pectin matrix) obtained by 1-4,
Lutein ester zeaxanthin tablet, lutein ester zeaxanthin soft capsule are comparative example (lutein ester, zeaxanthin
Respectively 4mg/, 0.8mg/).
Above-mentioned 5 kinds of samples are placed in above-mentioned beaker simulated intestinal fluid respectively, respectively at every 15min in 2h after sample is added
From intestines 200 μ L absorbing liquids of intracapsular taking-up, while supplying same volume blank simulated intestinal fluid.When surveying each with high performance liquid chromatography
Between put intestinal absorption liquid lutein, zeaxanthin concentration (parallel survey 3 times), calculate transit dose, and transit dose-time graph is made,
As shown in Figures 2 and 3.
By upper figure it is found that can be absorbed by quick enterocyte in 0-15min, then since tablet, capsule disintegration are fast
Uptake is basically unchanged, and the total amount within the 120min time through intestinal mucosa is far below other 3 sections of soft candy products；And this hair
Sample obtained by bright method and 2 sections of soft sweets agent have certain slow release effect in ingredient release, its interior transit dose of 0-15min compared with
Few, after 45min, functional component penetrates the sustainable growth of intestinal mucosa amount, correspond to abscissa value by curve and knows and the method for the present invention institute
It obtains sample Lutein ester and zeaxanthin passes through intestinal mucosa amount and is higher than common gelatin and jelly work, therefore show present invention side
Method can be improved the absorptivity of lutein ester, zeaxanthin.
Test 2- lutein ester and zeaxanthin study on the stability
Testing program: with (lutein ester, zeaxanthin, which feed intake, to be respectively as follows: according to embodiment 1, embodiment 2, embodiment 3
4mg/, 1.2mg/；8mg/, 2mg/；6mg/, 1.8mg/) and comparative example 1, comparative example 2 prepared by soft sweets sample
Tested (lutein ester, zeaxanthin feed intake respectively 4mg/, 1.2mg/).Sample is placed in PET bottle, in temperature
Accelerate to investigate 3 months under the conditions of being 65% for 40 DEG C, relative humidity, temperature and humidity are measured in real time, during test
0th, 1,2,3 the end of month is separately sampled primary, with high effective liquid chromatography for measuring sample Lutein ester, zeaxanthin,
And calculate retention rate.As a result as shown in table 1 below:
Table 1: embodiment and comparative example accelerated test situation
As shown in upper table, after 3 months accelerated tests, the retention rate of 3 embodiment sample Lutein esters, zeaxanthin
Higher than the retention rate of comparative example 1 and comparative example 2 Lutein ester and zeaxanthin, show the lutein ester and jade of the method for the present invention
The lutein ester zeaxanthin soft sweets that cream-coloured matter stability is prepared due to commonsense method.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention may be used also on the basis of the above description for those of ordinary skill in the art
To make other variations or changes in different ways, all embodiments can not be exhaustive here, it is all to belong to this hair
The obvious changes or variations that bright technical solution is extended out are still in the scope of protection of the present invention.
Claims (8)
1. a kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets, which is characterized in that this method comprises the following steps:
(1) in parts by weight, 60-80 parts of carragheens and 10-20 parts of pectin are soluble in water, heating makes it completely dissolved,
Glue is obtained, the dosage of the water is 10-18 times of carragheen and pectin total weight；
The glue is mixed with 2100-5000 part liquid syrup in terms of solid concentration 75%, is heated at 90 DEG C or more solid
Shape object content is 65%-70%, obtains mixed liquor A；The liquid syrup is the combination of syrup or syrup and sugar cube；
(2) in parts by weight, 5-20 parts of lutein esters, 1-10 parts of zeaxanthins and 5-10 parts of chitosan oligosaccharides are dissolved in ethyl alcohol
It is then dry that composite powder, the dosage of the ethanol solution are that lutein ester, zeaxanthin and chitosan oligosaccharide are total in aqueous solution
1-3 times of weight；
(3) composite powder of the mixed liquor A of step (1) and step (2) is mixed at 85-90 DEG C, adjusts pH to 3.5-4.5, after
The continuous soluble solid content that is heated to is 70%-75%, pours in mold, forms.
2. preparation method according to claim 1, which is characterized in that in step (1), the syrup is selected from sugar content
One or more of the glucose syrup of 50%-80%, fructose syrup, D-sorbite, maltitol liquor；The sugar cube is selected from
One of white granulated sugar, fructose, maltitol, antierythrite are a variety of.
3. preparation method according to claim 1, which is characterized in that in step (2), the molecular weight of the chitosan oligosaccharide is less than
1000Da。
4. preparation method according to claim 1, which is characterized in that in step (2), the quality of the ethanol water is dense
Degree is 30%-50%.
5. preparation method according to claim 1, which is characterized in that in step (2), the drying is spray drying or stream
It is dry to change bed.
6. preparation method according to claim 1, which is characterized in that in step (3), the reagent for adjusting pH value is lemon
Acid, lactic acid or malic acid.
7. preparation method according to claim 1, which is characterized in that described molding in step (3) method particularly includes:
Under the conditions of 40 DEG C -50 DEG C, drying to moisture content is 10-20%.
8. lutein ester zeaxanthin soft sweets made from a kind of -7 any preparation methods according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910269670.6A CN109924336A (en) | 2019-04-04 | 2019-04-04 | A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910269670.6A CN109924336A (en) | 2019-04-04 | 2019-04-04 | A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109924336A true CN109924336A (en) | 2019-06-25 |
Family
ID=66989249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910269670.6A Pending CN109924336A (en) | 2019-04-04 | 2019-04-04 | A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109924336A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112385839A (en) * | 2019-10-16 | 2021-02-23 | 富诺健康股份有限公司 | Lutein ester microcapsule and preparation method thereof |
| CN112450310A (en) * | 2020-10-30 | 2021-03-09 | 国药三良(浙江)健康科技有限公司 | Popping jelly containing compound eye protection factor and preparation method thereof |
| CN114586880A (en) * | 2022-02-25 | 2022-06-07 | 江苏康缘药业股份有限公司 | Eye-protecting soft sweets and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366436A (en) * | 2008-09-26 | 2009-02-18 | 昆明理工大学 | Birchleaf pear flower soft candy and preparation method thereof |
| CN101675747A (en) * | 2008-09-19 | 2010-03-24 | 内蒙古伊利实业集团股份有限公司 | Liquid diary products containing lutein ester and cryptoxanthin and production method thereof |
| CN102578346A (en) * | 2012-03-09 | 2012-07-18 | 华北制药集团新药研究开发有限责任公司 | Lutein ester soft sweet and preparation method thereof |
| CN102669377A (en) * | 2012-05-26 | 2012-09-19 | 华北制药集团新药研究开发有限责任公司 | Lutein ester soft candy and production method thereof |
| US20140112982A1 (en) * | 2011-06-10 | 2014-04-24 | Hangzhou Yangshengtang Healthcare Products Co., Ltd. | Chewable soft capsule shell and chewable soft capsule |
| CN107468664A (en) * | 2016-06-08 | 2017-12-15 | 沈阳药科大学 | A kind of venlafaxine sustained-release piece and preparation method thereof |
| CN109430878A (en) * | 2018-10-19 | 2019-03-08 | 天津科技大学 | Rutin chitosan oligosaccharide compound and its preparation method and application |
| CN109480132A (en) * | 2018-11-08 | 2019-03-19 | 湖北铭泰健康科学有限公司 | A kind of liquid healthy beverage and its preparation method and application containing chitosan oligosaccharide |
-
2019
- 2019-04-04 CN CN201910269670.6A patent/CN109924336A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675747A (en) * | 2008-09-19 | 2010-03-24 | 内蒙古伊利实业集团股份有限公司 | Liquid diary products containing lutein ester and cryptoxanthin and production method thereof |
| CN101366436A (en) * | 2008-09-26 | 2009-02-18 | 昆明理工大学 | Birchleaf pear flower soft candy and preparation method thereof |
| US20140112982A1 (en) * | 2011-06-10 | 2014-04-24 | Hangzhou Yangshengtang Healthcare Products Co., Ltd. | Chewable soft capsule shell and chewable soft capsule |
| CN102578346A (en) * | 2012-03-09 | 2012-07-18 | 华北制药集团新药研究开发有限责任公司 | Lutein ester soft sweet and preparation method thereof |
| CN102669377A (en) * | 2012-05-26 | 2012-09-19 | 华北制药集团新药研究开发有限责任公司 | Lutein ester soft candy and production method thereof |
| CN107468664A (en) * | 2016-06-08 | 2017-12-15 | 沈阳药科大学 | A kind of venlafaxine sustained-release piece and preparation method thereof |
| CN109430878A (en) * | 2018-10-19 | 2019-03-08 | 天津科技大学 | Rutin chitosan oligosaccharide compound and its preparation method and application |
| CN109480132A (en) * | 2018-11-08 | 2019-03-19 | 湖北铭泰健康科学有限公司 | A kind of liquid healthy beverage and its preparation method and application containing chitosan oligosaccharide |
Non-Patent Citations (2)
| Title |
|---|
| 夏文水: "《食品工艺学》", 31 January 2007, 中国轻工业出版社 * |
| 王绪敏等: "壳多糖及其衍生物在动物细胞培养中应用研究进展", 《中国海洋药物》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112385839A (en) * | 2019-10-16 | 2021-02-23 | 富诺健康股份有限公司 | Lutein ester microcapsule and preparation method thereof |
| CN112385839B (en) * | 2019-10-16 | 2022-11-08 | 富诺健康股份有限公司 | Lutein ester microcapsule and preparation method thereof |
| CN112450310A (en) * | 2020-10-30 | 2021-03-09 | 国药三良(浙江)健康科技有限公司 | Popping jelly containing compound eye protection factor and preparation method thereof |
| CN114586880A (en) * | 2022-02-25 | 2022-06-07 | 江苏康缘药业股份有限公司 | Eye-protecting soft sweets and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102665697B (en) | Acid resistant capsules | |
| CN105456196B (en) | Curcumin composite particles and its preparation method and application | |
| CN109924336A (en) | A kind of preparation method of high-selenium corn lutein ester zeaxanthin soft sweets | |
| EP1117736B2 (en) | Modified starch film compositions | |
| CN104886554B (en) | Quick-fried pearl soft capsule and preparation method thereof | |
| CN107148266A (en) | Preparation comprising particle | |
| WO2020113811A1 (en) | Biopolymer nanosphere containing nicotinamide mononucleotide, preparation method therefor and use thereof | |
| JP7263465B2 (en) | Composition containing hydrophilic colored food concentrate and resulting hard capsule | |
| CN109044981A (en) | A kind of Pregabalin intragastric floating slowly releasing piece and preparation method thereof | |
| CN105456223B (en) | Mesalazine sustained release pellet and preparation method thereof and Mesalazine spansule | |
| CN103784396B (en) | Ibuprofen oral micropill xerogel and preparation method thereof | |
| CN106794143A (en) | The method of inducing satiety | |
| CN109908089A (en) | Nanosphere and the preparation method and application thereof containing NADH or NADPH | |
| JPS6023323A (en) | Medicinal composition | |
| CN109875965A (en) | A kind of Azithromycin for Suspension | |
| CN106727278A (en) | A kind of Timoptic-XE agent and preparation method thereof | |
| CN110075321B (en) | Tibetan medicine Anerning granular placebo and preparation method thereof | |
| TWI338583B (en) | Solid pharmaceutical formulation | |
| CN107412198A (en) | Duloxetine hydrochloride enteric slow release granule and preparation method thereof | |
| CN111557920A (en) | Lipoic acid-containing tablet and preparation method thereof | |
| CN107970215B (en) | A kind of Sugarless type Cefixime granule and preparation method thereof | |
| CN102327233B (en) | Dimercaptosuccinic acid granular formulation | |
| AU2021107154A4 (en) | An easy chewing gel candy with transparent skin and preparation method thereof | |
| CN110251481A (en) | A kind of veterinary tilmicosin taste masking slow-releasing granules and its preparation process | |
| CN110101687B (en) | Metformin hydrochloride sustained release preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210922 Address after: No. 1980 Hongqi South Road, Maanshan Economic and Technological Development Zone, Anhui Province Applicant after: Xianle Health Technology (Anhui) Co.,Ltd. Address before: 510623 rooms 4003 and 4004, No. 68, Huacheng Avenue, Tianhe District, Guangzhou, Guangdong Applicant before: WEWOW HEALTH INDUSTRY Co.,Ltd. |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190625 |