CN109923115A - 咪唑并[1’,2’:1,6]吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂 - Google Patents
咪唑并[1’,2’:1,6]吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂 Download PDFInfo
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- CN109923115A CN109923115A CN201880003184.3A CN201880003184A CN109923115A CN 109923115 A CN109923115 A CN 109923115A CN 201880003184 A CN201880003184 A CN 201880003184A CN 109923115 A CN109923115 A CN 109923115A
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- alkyl
- independently selected
- naphthenic base
- heterocyclic ring
- base
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
提供通式(I)的咪唑并[1',2':1,6]吡啶并[2,3‑d]嘧啶类化合物,它们可用于治疗细胞增殖障碍。化合物是有广谱、强烈活性的细胞周期蛋白依赖性激酶(CDK)的抑制剂。
Description
PCT国内申请,说明书已公开。
Claims (12)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201710368799 | 2017-05-23 | ||
CN2017103687993 | 2017-05-23 | ||
PCT/CN2018/087665 WO2018214846A1 (zh) | 2017-05-23 | 2018-05-21 | 咪唑并[1',2':1,6]吡啶并[2,3-d]嘧啶类化合物作为蛋白激酶抑制剂 |
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CN109923115A true CN109923115A (zh) | 2019-06-21 |
CN109923115B CN109923115B (zh) | 2021-06-01 |
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US (1) | US11091485B2 (zh) |
CN (1) | CN109923115B (zh) |
WO (1) | WO2018214846A1 (zh) |
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CN114174301B (zh) * | 2019-08-02 | 2024-03-15 | 成都赛璟生物医药科技有限公司 | 1h-[1,2,3]三唑并[4,5-h]喹唑啉类化合物作为蛋白激酶抑制剂 |
EP4204093A1 (en) * | 2020-08-27 | 2023-07-05 | Shengke Pharmaceuticals (Jiangsu) Ltd. | 1h-imidazo [4,5-h] quinazoline compound as novel selective flt3 inhibitors |
WO2024067820A1 (en) * | 2022-09-30 | 2024-04-04 | Shenzhen Ionova Life Science Co., Ltd. | Tricyclic compounds as cdk inhibitors and methods of using same |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1646529A (zh) * | 2002-04-03 | 2005-07-27 | 霍夫曼-拉罗奇有限公司 | 咪唑并稠合化合物 |
WO2013007708A1 (en) * | 2011-07-08 | 2013-01-17 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for treatment of liver cancer |
CN105481858A (zh) * | 2014-10-11 | 2016-04-13 | 上海医药集团股份有限公司 | 一种含氮稠杂环化合物、其制备方法、组合物及应用 |
-
2018
- 2018-05-21 CN CN201880003184.3A patent/CN109923115B/zh active Active
- 2018-05-21 US US16/619,222 patent/US11091485B2/en active Active
- 2018-05-21 WO PCT/CN2018/087665 patent/WO2018214846A1/zh active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1646529A (zh) * | 2002-04-03 | 2005-07-27 | 霍夫曼-拉罗奇有限公司 | 咪唑并稠合化合物 |
WO2013007708A1 (en) * | 2011-07-08 | 2013-01-17 | Helmholtz-Zentrum für Infektionsforschung GmbH | Medicament for treatment of liver cancer |
CN105481858A (zh) * | 2014-10-11 | 2016-04-13 | 上海医药集团股份有限公司 | 一种含氮稠杂环化合物、其制备方法、组合物及应用 |
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