CN109912717B - Antibodies that bind CD40 and uses thereof - Google Patents
Antibodies that bind CD40 and uses thereof Download PDFInfo
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- CN109912717B CN109912717B CN201910160181.7A CN201910160181A CN109912717B CN 109912717 B CN109912717 B CN 109912717B CN 201910160181 A CN201910160181 A CN 201910160181A CN 109912717 B CN109912717 B CN 109912717B
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Images
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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Abstract
Description
Cloning | Subtype of cell | Expression Titers (mg/1) | |
| Mouse IgG | 1/kappa | 24.744 |
| Mouse IgG | 1/kappa | 31.111 |
| Mouse IgG | 1/kappa | 33.889 |
| Mouse IgG | 1/kappa | 18.667 |
| Mouse IgG | 1/kappa | 7.778 |
| Mouse IgG | 1/kappa | 10.000 |
| Mouse IgG | 1/kappa | 65.333 |
| Mouse IgG | 1/kappa | 11.667 |
16F4 | Mouse IgG2 b/kappa | 14.000 | |
| Mouse IgG | 1/kappa | 12.778 |
| Mouse IgG | 1/kappa | 12.22 |
| Mouse IgG | 1/kappa | 20.39 |
| Mouse IgG | 1/kappa | 17.22 |
| Mouse IgG | 1/kappa | 95.73 |
91E4 | Mouse IgG2 a/kappa | 4.47 | |
| Mouse IgG | 1/kappa | 18.94 |
| Mouse IgG | 1/kappa | 39.97 |
82D3 | Mouse IgG2 a/kappa | 16.27 | |
23B8 | Mouse IgG2 a/kappa | 32.33 | |
| Mouse IgG | 1/kappa | 1.44 |
Antibodies | HEK-Blue EC50(ng/mL) |
RO7009789 | 23.26 |
ADC1013 | 1034 |
13A2 | 12.61 |
16A6 | 11.37 |
7B4 | 26.14 |
50F6 | 42.16 |
101C12 | 175.2 |
77D9 | 22.26 |
35C9 | 86.08 |
37G3 | 146.1 |
79D7 | 55.29 |
142F7 | 64.77 |
89D11 | 91.06 |
91E4 | 152.7 |
82D3 | 285.4 |
23B8 | 3373 |
51F7 | 6173 |
92F6 | 263.7 |
19H4 | 92.79 |
16F4 | 252.1 |
29A10 | 139.8 |
9A7 | 61.96 |
Antibody chains | PDB encoding of template structures | Sequence identity | Sequence similarity |
13A2 heavy chain | 5E2T | 71% | 83% |
13A2 light chain | 1DLF | 84% | 92% |
7B4 heavy chain | 5E2T | 87% | 90% |
7B4 light chain | 1DLF | 87% | 95% |
Antibodies | ka | kd | KD |
RO700789 | 1.07E+5 | 1.83E-4 | 1.71E-9 |
ADC1013 | 1.2E+6 | 3.48E-2 | 2.9E-08 |
13A2 | 4.84E+05 | 1.73E-03 | 3.58E-09 |
13A2-VH0VL0 | 3.96E+05 | 1.14E-02 | 2.88E-08 |
13A2-VH2VL2 | 8.23E+05 | 1.71E-03 | 2.08E-09 |
13A2-VH2VL3 | 7.35E+05 | 2.61E-03 | 3.55E-09 |
13A2-VH3VL2 | 8.25E+5 | 2.42E-3 | 2.93E-09 |
13A2-VH3VL3 | 5.98E+5 | 4.59E-3 | 7.68E-09 |
7B4 | 1.00E+06 | 3.6E-03 | 3.6E-09 |
7B4-VH0VL0 | 2.75E+06 | 6.8E-03 | 2.47E-09 |
7B4-VH2VL2 | 2E+06 | 5.81E-03 | 2.91E-09 |
7B4-VH2VL3 | 1.78E+06 | 6.39E-03 | 3.6E-09 |
784-VH3VL2 | 1.46E+06 | 6.15E-03 | 4.2E-09 |
784-VH3VL3 | 2.13E+06 | 4.88E-03 | 2.99E-09 |
Group/day of the |
4 | 6 | 8 | 11 | 14 | 18 | 21 | 25 |
13A2- VH3VL3 | 22.9± 0.5 | 20.6± 0.5 | 22.5± 0.5 | 24.1± 0.5 | 24.7± 0.5 | 25.2± 0.5 | 24.7± 0.5 | 25.4± 0.8 |
7B4- VH2VL2 | 23.0± 0.3 | 21.2± 0.2 | 23.4± 0.2 | 23.8± 0.2 | 22.7± 0.5 | 24.4± 0.2 | 22.2± 0.5 | 22.9± 0.5 |
RO7009789 | 23.9± 0.3 | 21.5± 0.4 | 22.9± 0.4 | 22.6± 0.3 | 22.2± 0.4 | 22.1± 0.5 | 21.8± 0.4 | 19.6± 0.5 |
APX005 | 22.6± 0.3 | 20.8± 0.3 | 22.9± 0.3 | 23.1± 0.4 | 23.4± 0.6 | 24.1± 0.4 | 21.5± 0.6 | 22.0± 0.7 |
PBS | 23.3± 0.4 | 23.2± 0.3 | 24.2± 0.4 | 23.7± 0.3 | 25.1± 0.4 | 26.5± 0.4 | 27.8± 0.5 | 30.7± 0.6 |
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JP2022553108A (en) * | 2019-10-23 | 2022-12-21 | リビジェン バイオファーマ ホールディングス リミテッド | Anti-CD40 binding molecules and bispecific antibodies including such |
CN112924683B (en) * | 2019-12-05 | 2023-08-29 | 张曼 | Application of urine exosome CD40 protein and polypeptide fragment thereof in bladder cancer |
KR102536302B1 (en) * | 2020-02-25 | 2023-05-26 | 국립암센터 | Monoclonal antibody specifically binding to TIM-3 and uses thereof |
CN115073597A (en) * | 2021-03-12 | 2022-09-20 | 北京智仁美博生物科技有限公司 | Anti-human CD40 antibodies and uses thereof |
EP4365200A1 (en) * | 2021-06-28 | 2024-05-08 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Anti-cd40 antibody, antigen-binding fragment and medical use thereof |
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CA3232304A1 (en) * | 2021-09-26 | 2023-03-30 | Chen SHEN | Use of anti-cd40 antibody |
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