CN109908372A - The preparation method of radio pill in a kind of 3D enteron aisle capsule - Google Patents
The preparation method of radio pill in a kind of 3D enteron aisle capsule Download PDFInfo
- Publication number
- CN109908372A CN109908372A CN201910270397.9A CN201910270397A CN109908372A CN 109908372 A CN109908372 A CN 109908372A CN 201910270397 A CN201910270397 A CN 201910270397A CN 109908372 A CN109908372 A CN 109908372A
- Authority
- CN
- China
- Prior art keywords
- preparation
- radioactive
- capsule
- oso
- radioactive source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention provides a kind of preparation method of radio pill in 3D enteron aisle capsule, including radioactive substance concentration, radioactive substance oxidation with separate, isotopic separation, radioactive substance capture, radioactive substance preparation reduction, the spherical molding of radioactive source and molding reinforcing step.The present invention provides a kind of preparation method of radio pill in 3D enteron aisle capsule, radioactive source needed for Os preparation is imaged is starved using element, then the radioactive source extracted is placed in the container molding of Low emissivity absorptivity, it carried out reinforcing molding, it is packaged finally by polymer binder to radioactive material after molding is reinforced, thus radioactive source needed for forming the imaging of 3D enteron aisle capsule.
Description
Technical field
The present invention relates to technical field of medical equipment, more particularly to a kind of preparation of radio pill in 3D enteron aisle capsule
Method.
Background technique
Colorectal cancer is a kind of common fatal disease, and grade malignancy is high.According to statistics, the annual colorectal cancer of China is new
Fall ill 33.1 ten thousand people of example, and the patient for dying of the disease every year has 15.9 ten thousand people, and disease incidence shelter has the third position of malignant tumour.Enteron aisle
Polyp is a kind of common abnormal tissue growth, is formed in the inner membrance of colon or rectum, while being also the master for causing colorectal cancer
Want one of risk factors.Traditional colonoscopy is most commonly seen colorectal cancer detection method, is found by endoscope
And pre-cancerous tissue or precancerous polyp are eradicated, it is greatly improved the survival rate and cure rate of patient.Therefore early lesion group
The discovery knitted is the key that treatment colorectal cancer with operation removal.
Traditional colonoscopy needs Colon and rectum mucomembranous surface high-visible, and the clean-up performance of enteron aisle determines inspection
Quality, difficulty, speed and the completeness looked into.It checks that preceding patient need to shift to an earlier date 2 to 3 days fasting foods, and drinks a large amount of spies
Different clear weak solution takes orally specific cathartic or cleaning intestinal, so that Colon and rectum is kept to clean, the normal life of extreme influence patient.
In inspection, patient can experience pressure, abdominal distension or colic pain, and enteroscopy needs lasting 1 to 2 hour, causes to patient larger
Body with bear at heart.Conventional junction proctoscope detection simultaneously is limited in scope and visual angle is smaller, cannot effectively carry out to Colon and rectum
It is comprehensive to check.And the observation of conventional junction proctoscope is two dimensional image, cannot obtain the three-dimensional structure of the pathological tissues such as polyp
Information easily causes enterorrhagia even enterobrosis in resection operation.It is postoperative to cause colic pain, abdominal distension, bleeding or hair
Heat symptom-complex shape.Therefore, traditional colonoscopy preparatory period and inspection duration are long, and cleaning situation is to detection in enteron aisle
Accuracy be affected, entire inspection cycle easily causes larger burden to the body of patient and at heart.In addition to this, colonoscopy
Reusability also increases the difficulty and cost of disinfection, increases the probability of cross-infection and complication.Therefore it designs a
Efficiently, convenient, safe, disposable, while can reflect the x-ray capsule 3D endoscope system of enteron aisle three-dimensional structure information comprehensively
System, can not only provide convenience for clinician, greatly reduce enteroscopy workload, moreover it is possible to save disinfection cost, substantially reduce
Because operating or sterilizing the risk of improper generation.Detection process painless simultaneously can farthest reduce the at heart and raw of patient
Reason burden improves popularization degree and acceptance of the colonoscopy in clinic.
X-ray capsule 3D endoscopic system is received by swallowing in-vivo imaging capsule and intestinal walls contrast agent using external signal
After transmitting apparatus acquisition enhances via contrast agent, the fluorescence and backward compton scattering count signal that intestinal wall is reflected carry out three
It ties up structure and draws imaging.How imaging radiation source is had in imaging capsule, the performance in imaging radiation source directly affects imaging effect, because
This, providing the reliable and stable imaging radiation source of one kind is very important.
Summary of the invention
The technical problems to be solved by the present invention are: in order to overcome the shortcomings in the prior art, the present invention provides a kind of 3D
The preparation method of radio pill in enteron aisle capsule.
The present invention solves its technical problem technical solution to be taken: radio pill in a kind of 3D enteron aisle capsule
Preparation method, the radioactive source preparation process in the interior imaging capsule mainly include that radioactive substance preparation and radioactive source are solid
State forms two steps.Wherein radioactive substance preparation step specifically includes that preparation radioactivity condensed matter, radioactive substance oxygen
Change with separate, isotopic separation, radioactive substance capture and radioactive substance restore；Radioactive source formed solid step is mainly wrapped
Include: the spherical molding of radioactive source and radioactive source molding are reinforced.Through the above steps, by radiogen be prepared as half-life period it is stable,
Radiation intensity is moderate and the coccoid radioactive source of stable molding, is placed in the radiation source container of the in-vivo imaging capsule, is
Capsule imaging provides reliable radioactive source.
Wherein, (Os) mainly is starved using radioactive substance prepare reliable and stable imaging radiation source.In a certain embodiment,
Radioactive source prepares material and is adopted as Os, but is not limited to Os, and W181, Hg197, T1201 etc. also can be used.
Since Os itself is without radioactivity, is bombarded by neutron current, Os190 may make to generate Os191 because of nuclear reaction
And therefore Ir192 in the preparation radioactivity condensed matter step, bangs the Os190 of concentration using subflow is hankered to obtain
The mixed-powder of radioactive Os190, Os191 and Ir192 (Ir192).In the oxidation of institute's radioactive substance and separating step,
The mixed-powder of Os190, Os191 and Ir192 (Ir192) are mixed and heated with oxidant, after reaching specific temperature,
It include OsO to obtain4Gaseous oxidation mixture, so that Os (190,191) be separated with Ir192.In a particular embodiment,
Oxidant is oxide, the potassium permanganate (KMnO of chromium4), hydrogen peroxide (H2O2) one of with sulfuric acid (H2SO4) solution mixing
Object, corresponding heating temperature are respectively 110 DEG C.Here the Os of gaseous oxidation mixture includes isotope Os190 and Os191,
Therefore, in the isotopic separation step, using isotope separations such as electromagnetic method, centrifugal process or thermal diffusions to including OsO4
Gaseous oxidation mixture separated, retain Os191 formed OsO4Gaseous oxygen compound and the OsO for removing Os190 formation4Gas
State oxide.In radioactive substance capture step, radioactive substance capture, is to make osmium tetroxide (OsO4) gas passes through
Cooling potassium hydroxide (KOH) solution, thus by OsO4Gas is absorbed and (is captured), forms K2[OsO4(OH)2] solution,
Ir element is excluded, to exclude the interference of Ir impurity；In the radioactive substance reduction step, in K2[OsO4(OH)2] molten
NaHS is added in liquid, OsS is precipitated2, OsS is obtained by being dried2Powder.In the spherical forming step of the radioactive source, utilize
The drying OsS obtained in the radioactive substance preparation step2Powder is mixed with polymer binder, is subsequently placed in low spoke
It penetrates in the container molding of absorptivity and is shaped to solid globules shape, and finally obtain the required radiation of the in-vivo imaging capsule imaging
Source.It is relatively more that radioactive source reinforces molding method.2 kinds of methods are simply enumerated below.(1) using polymeric binder with prepare
Radiation source power mixed, and mixed substance is placed in the shaping grinding apparatus of Low emissivity absorptivity.In mixture
In matter solidification process, from three slow rotating grinding tools of change in coordinate axis direction of cartesian coordinate system, until mixture is fully cured,
To form the radioactive source bead that can be used for being imaged.(2) radioactive powder is merged with the powder of Low emissivity absorptivity, such as aluminium
Powder or ceramic binder.Mixture is sintered, to form coccoid solid.Finally sintered bead is impregnated
In polymer viscose, to further reinforce radio pill, its rupture is prevented.
In a certain embodiment, polymer binder can be but be not limited to transparent epoxy glue.
The beneficial effects of the present invention are: in a kind of 3D enteron aisle capsule provided by the invention radio pill preparation method,
Element starves radioactive source needed for Os preparation is imaged, and is then placed in the radioactive source extracted in the container molding of Low emissivity absorptivity,
It carried out reinforcing molding, be packaged finally by polymer binder to radioactive material after molding is reinforced, to form 3D
Radioactive source needed for the imaging of enteron aisle capsule.Program preparation flow is simple, is easier to obtain to raw material needed for preparation.It prepares
Imaging radiation source stability it is strong, interfere less between radioactive source, be not easy due to downthrust that deformation occurs or fragmentation.Meanwhile
The long half time of prepared radioactive source, needed for meeting enteron aisle imaging, and radioactive substance is uniformly distributed in all directions, Neng Goubao
It is uniform to demonstrate,prove brightness of image, really, clearly.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is radioactive source preparation flow figure of the present invention.
In figure: 16, prepare radioactivity condensed matter, 17, radioactive substance oxidation and separate, 18, isotopic separation, 19,
Radioactive substance capture, 20, radioactive substance reduction, 21, the spherical molding of radioactive source, 22, radioactive source molding reinforcing.
Specific embodiment
Presently in connection with attached drawing, the present invention is described in detail.This figure is simplified schematic diagram, is only illustrated in a schematic way
Basic structure of the invention, therefore it only shows the composition relevant to the invention.
As shown in Figure 1, in a kind of 3D enteron aisle capsule of the invention radio pill preparation method, the interior imaging capsule
In radioactive source preparation process mainly include, radioactive substance preparation and two steps of radioactive source formed solid.Wherein radiate
Property substance preparation step specifically include that preparation radioactivity condensed matter 16, radioactive substance oxidation and separate 17, isotopic separation
18, radioactive substance capture 19 and radioactive substance reductase 12 0；Radioactive source formed solid step specifically includes that radioactive source is spherical
Molding 21 and radioactive source molding reinforce 22.Through the above steps, radiogen is prepared as half-life period stabilization, radiation intensity is fitted
In and stable molding coccoid radioactive source, be placed in the radiation source container of the in-vivo imaging capsule, for capsule imaging mention
For reliable radioactive source.Wherein, (Os) mainly is starved using radioactive substance prepare reliable and stable imaging radiation source.In a certain implementation
In example, radioactive source prepares material and is adopted as Os, but is not limited to Os.In 16 step of preparation radioactivity condensed matter, adopt
The mixed-powder of radioactive Os190, Os191 and Ir192 (Ir192) are obtained with the Os190 for hankering subflow Hong concentration.
In 18 step of isotopic separation, using 18 method of the isotopic separations such as electromagnetic method, centrifugal process or thermal diffusion to the preparation
The Os190 and Os191 obtained in radioactivity condensed matter 16 is separated, and is retained Os191 and is removed Os190.It is put described
In 0 step of penetrating property substance reductase 12, to Os191, Ir192 obtained in 18 step of isotopic separation by the way of heating
Mixture carries out oxidation processes, and obtaining includes osmium tetroxide (Os04) gaseous oxidation mixture.So by the gaseous state after oxidation
Mixture is melted into cooling potassium hydroxide solution (KOH), thus shape K2 [OsO4(OH)2] and exclude the interference of Ir impurity.Finally exist
NaHS is added in solution, OsS is precipitated2, OsS is obtained by being dried2Powder.In the spherical molding and forming step,
Utilize the drying OsS obtained in the radioactive substance preparation step2Powder is mixed with polymer binder, is subsequently placed in
It is shaped to solid globules shape in the container molding of Low emissivity absorptivity, and finally obtains needed for the in-vivo imaging capsule imaging
Radioactive source.In a certain embodiment, polymer binder can be but be not limited to transparent epoxy glue.
Embodiment one:
Appropriate concentration Os is chosen, using the neutron current bombardment concentration Os of 1E14n/cm2 to 5E15n/cm2, until generating foot
Volume production object generates the concentration iridium of the concentration Os and 1.8mg of 21mg in the present embodiment, wherein it includes Os191 in osmium that 21mg, which is concentrated,
With a small amount of unreacted Os190.Their mixed-powder is placed in containing 18mmol CrO3, concentration be 25% 135ml
H2SO4In solution.Said mixture is heated to 110 degrees Celsius, to release OsO4Gas, and control the quantum of output of gas
For 30cc per minute.Then laser isotope separation is used, by the OsO comprising Os190 and Os1914Separation removes Os190
And retain Os191.By OsO4(Os191) the 250ml KOH solution that gas input concentration is 25% forms K2[OsO4(OH)2].Most
The NaHS solution that 120ml concentration is 10% is added afterwards, so that OsS be precipitated2Crystal.By the OsS of precipitation2Crystal is centrifuged,
And cleaned 5 times with the water that pH value is about 7, finally by OsS2Crystal is dried in a vacuum furnace, and temperature is controlled at 60 degrees Celsius,
Air pressure is 20 millibars, and drying time is 48 hours.
Embodiment two:
Appropriate concentration Os is chosen, using the neutron current bombardment concentration Os of 1E14n/cm2 to 5E15n/cm2, until generating foot
Volume production object generates the concentration osmium of 22.6mg and the iridium of 2.7mg in the present embodiment as reaction raw material, by their mixed powder
End is placed in containing 26mol KMnO4, concentration be 25% 135ml H2SO4In solution.Said mixture is passed through into aluminum heater
110 degrees Celsius are heated to, pushes OsO using nitrogen4Gas is with 30cc output per minute.Then atomicvapor laser isotope separation is used
Method, by the OsO comprising Os190 and Os1914Separation removes Os190 and retains Os191.Then by OsO4(Os191) gas inputs
The 100ml KOH solution that concentration is 10% forms K2[OsO4(OH)2].It is eventually adding the NaHS solution that 2.5ml concentration is 10%,
To which OsS be precipitated2Crystal.By the OsS of precipitation2Crystal is centrifuged, and is cleaned 5 times with the water that pH value is about 7, finally will
OsS2Crystal is dried in a vacuum furnace, and at 60 degrees Celsius, air pressure is 20 millibars for temperature control, and drying time is 48 hours.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff
Various changes and amendments can be carried out without departing from the scope of the present invention completely.The technical scope of this invention is not
The content being confined on specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.
Claims (5)
1. the preparation method of radio pill in a kind of 3D enteron aisle capsule, it is characterised in that: the imaging radiation source be capsule at
As providing radioactive source, including radioactive substance preparation and two steps of radioactive source formed solid, wherein radioactive substance preparation
Including preparation radioactivity condensed matter, radioactive substance oxidation with separate, isotopic separation, radioactive substance capture and radiate
Property substance reduction；Radioactive source formed solid includes that the spherical molding of radioactive source and radioactive source molding are reinforced.
2. the preparation method of radio pill in 3D enteron aisle capsule as described in claim 1, it is characterised in that: use Os conduct
Radioactive source prepares material, then preparation method specifically includes:
Prepare radioactivity condensed matter, using hanker subflow Hong concentration Os190 to obtain have radioactive Os190,
The mixed-powder of Os191 and Ir192；
Radioactive substance is aoxidized and is separated, and mixed-powder and oxygen is concentrated in the radioactivity of obtained Os190, Os191 and Ir192
Agent is mixed and is heated, and after reaching specific temperature, radioactivity is concentrated mixed-powder and generates OsO4Gaseous oxidation mixture,
To be separated with Ir192；
Isotopic separation, OsO4Gaseous oxidation mixture in Os include isotope Os190 and Os191, using isotope point
From method to OsO4Gaseous oxidation mixture in the OsO that is formed of the OsO4 gaseous oxygen compound that is formed of the Os190 that obtains and Os1914
Gaseous oxygen compound is separated, and the OsO that Os191 is formed is retained4Gaseous oxygen compound and the OsO for removing Os190 formation4Gaseous oxidation
Object；
Radioactive substance capture, by the OsO after separation4Gaseous oxygen compound is by cooling KOH solution, thus by OsO4Gas is inhaled
Receipts form K2[OsO4(OH)2] solution, Ir element is excluded；
Radioactive substance reduction, in K2[OsO4(OH)2] NaHS is added in solution OsS is precipitated2, OsS is obtained by being dried2Powder
End；
The spherical molding of radioactive source, dry OsS2Powder is mixed with polymer binder, be subsequently placed in Low emissivity absorptivity at
It is shaped to solid globules shape in type container, and finally obtains the required radioactive source of the in-vivo imaging capsule imaging.
3. the preparation method of radio pill in 3D enteron aisle capsule as claimed in claim 2, it is characterised in that: the isotope
Partition method is electromagnetic method, centrifugal process or thermal diffusion.
4. the preparation method of radio pill in 3D enteron aisle capsule as claimed in claim 2, it is characterised in that: the macromolecule
Adhesive uses transparent epoxy glue.
5. the preparation method of radio pill in 3D enteron aisle capsule as claimed in claim 2, it is characterised in that: the oxidant
The mixture of one of oxide, potassium permanganate and hydrogen peroxide for chromium with sulfuric acid solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910270397.9A CN109908372A (en) | 2019-04-04 | 2019-04-04 | The preparation method of radio pill in a kind of 3D enteron aisle capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910270397.9A CN109908372A (en) | 2019-04-04 | 2019-04-04 | The preparation method of radio pill in a kind of 3D enteron aisle capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109908372A true CN109908372A (en) | 2019-06-21 |
Family
ID=66968643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910270397.9A Pending CN109908372A (en) | 2019-04-04 | 2019-04-04 | The preparation method of radio pill in a kind of 3D enteron aisle capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109908372A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109195920A (en) * | 2016-07-06 | 2019-01-11 | 检验盖有限公司 | Radiation source for inner cavity imaging capsule |
-
2019
- 2019-04-04 CN CN201910270397.9A patent/CN109908372A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109195920A (en) * | 2016-07-06 | 2019-01-11 | 检验盖有限公司 | Radiation source for inner cavity imaging capsule |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Liu et al. | Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes | |
| Zhang et al. | Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream | |
| Liu et al. | Anti‐Biofouling Polymer‐Decorated Lutetium‐Based Nanoparticulate Contrast Agents for In Vivo High‐Resolution Trimodal Imaging | |
| KR20080067333A (en) | Imaging agents comprising silicon | |
| Nieves et al. | Silver chalcogenide nanoparticles: a review of their biomedical applications | |
| CN103623437A (en) | Nano probe material for imaging, and preparation method and application thereof | |
| JP7419415B2 (en) | arsenic composition | |
| JP2016527492A (en) | Germanium production process | |
| CN109453400B (en) | Radioactive iodine labeled gold nano material and preparation method and application thereof | |
| CN109908372A (en) | The preparation method of radio pill in a kind of 3D enteron aisle capsule | |
| Zhuang et al. | Gram-scale synthesis of a neodymium chelate as a spectral CT and second near-infrared window imaging agent for visualizing the gastrointestinal tract in vivo | |
| CN105797174B (en) | A kind of magnetic resonance imaging contrast and preparation method thereof based on nano graphene oxide | |
| CN105288625A (en) | Porous Bi2Se3 nano sponge material as well as preparation method and application thereof | |
| Chen et al. | An extended NIR‐II superior imaging window from 1500 to 1900 nm for high‐resolution in vivo multiplexed imaging based on lanthanide nanocrystals | |
| US10737949B2 (en) | Radiation source for intra-lumen imaging capsule | |
| CN104667301A (en) | Preparation method of AuNCs-A@CaP nano particle with monodisperse core-shell structure and application of AuNCs-A@Ca nano particle | |
| Wang et al. | Yb/Er/Ho-engineered rare earth fluoride nanoparticles to unlock multimodal in vivo medical imaging | |
| Kamath et al. | Role of bronchoscopy in early diagnosis of lung cancer | |
| WO2016119019A1 (en) | Compositions containing arsenic and their use in methods of treatment | |
| WO2012075707A1 (en) | Duodenoscope system integrated with infrared thermal scanner | |
| JP2003536055A (en) | Method for generating [18F] fluoride ion | |
| CN110025284A (en) | A kind of x-ray capsule 3D endoscopic system | |
| CN210408354U (en) | X-ray capsule 3D endoscope system | |
| JP2003167096A (en) | Method of preparing 15-o-carbon monoxide | |
| CN104379182A (en) | Amorphous carbon supported nanoparticles comprising oxides of lanthanides and method for preparing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |