CN109908001A - A kind of berberine powder liquid paste and preparation method thereof applied to direct pulp capping - Google Patents
A kind of berberine powder liquid paste and preparation method thereof applied to direct pulp capping Download PDFInfo
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- CN109908001A CN109908001A CN201910351167.5A CN201910351167A CN109908001A CN 109908001 A CN109908001 A CN 109908001A CN 201910351167 A CN201910351167 A CN 201910351167A CN 109908001 A CN109908001 A CN 109908001A
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- berberine
- soybean lecithin
- powder liquid
- ethyl alcohol
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Abstract
The invention discloses a kind of berberine powder liquid pastes applied to direct pulp capping, raw material including following parts by weight: 30~60 parts of berberine, 30~60 parts of ethyl alcohol, 30~45 parts of soybean lecithin, 30~45 parts of methylene chloride, 25~40 parts of filler, 20~35 parts of adhesive, 20~35 parts of additive, 30~60 parts of physiological saline, preparation method, the following steps are included: S1: the berberine of above-mentioned parts by weight being dissolved in the ethyl alcohol, 35~50 DEG C of heating obtains berberine ethanol solution；S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin solution is mixed to get；S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer.The present invention has antibacterial, anti-inflammatory, induced osteogenesis triple function, makes it have the application potential for repairing inflamed human dental pulp, is worthy to be popularized.
Description
Technical field
The present invention relates to field of medical technology more particularly to a kind of berberine powder liquid paste applied to direct pulp capping and its
Preparation method.
Background technique
Tooth the reasons such as bad, wound can cause dental pulp exposure to infect because of dental caries, cause not recoverability pulpitis.Generally acknowledged at present
Effective treatment method is root canal therapy, but hat side's defect of postoperative tooth is larger, root canal wall is thinning and loses vital pulp, leads to tooth
The drag reduced performance of tooth, Yi Fasheng odontagma.In addition, root canal treatment is complicated for operation, costly, treatment time is longer, also deposit
The risks such as wear in fracture, side.Therefore, effective drug and treatment method are explored, treats tooth under the premise of retaining vital pulp
Marrow inflammation is the common hope of doctors and patients.
Jamaicin (Berberine, BBR) also known as berberine are the quaternary amine type iloquinoline derivatives extracted from the plants such as the coptis
Alkaloid, the plant (such as coptis) containing jamaicin have the application history of more than one thousand years in China's Chinese medicine.In recent years the study found that
Jamaicin has antibacterial, anti-inflammatory, anti-oxidant, antitumor, induced osteogenesis, reduces a variety of effects such as blood glucose.
Jamaicin is a kind of broad-spectrum antibiotic, and in vitro study shows the has a broad antifungal spectrum of jamaicin, and low concentration is just to a variety of leather
Blue negative bacterium, gram positive bacteria, influenza virus and fungi etc. significantly inhibit effect, show good bactericidal effect.Separately have
The study found that jamaicin significantly inhibits a variety of oral cavity common bacterias, such as Fusobacterium nucleatum, Prevotella intermedia, excrement
Enterococcus and Porphyromonas endodontalis in vitro.
It is multinomial the study found that jamaicin can play anti-inflammatory effect in different histocytes.Jamaicin can block
P38 MAPK signal path reduces the secretion of IL-2 after phytohemagglutinin (PHA) processing jurkat cell.Jamaicin can
NF- κ b signal path is blocked, the inflammatory reaction of 264.7 macrophage of RAW of lipopolysaccharides (LPS) induction is inhibited.It merits attention
It is that jamaicin can block p38 MAPK and NF- κ b signal path simultaneously, the mast cell inflammatory reaction for inhibiting IL-33 to mediate；
Inflammatory reaction and apoptosis when inhibition myocardial cell injury.
Summary of the invention
Technical problems based on background technology, the invention proposes a kind of berberine powder liquid applied to direct pulp capping
Paste and preparation method thereof.
A kind of berberine powder liquid paste applied to direct pulp capping proposed by the present invention, the raw material including following parts by weight:
30~60 parts of berberine, 30~60 parts of ethyl alcohol, 30~45 parts of soybean lecithin, 30~45 parts of methylene chloride, filler 25~40
Part, 20~35 parts of adhesive, 20~35 parts of additive, 30~60 parts of physiological saline.
Preferably, a kind of berberine powder liquid paste applied to direct pulp capping, the raw material including following parts by weight:
40~50 parts of berberine, 40~50 parts of ethyl alcohol, 35~40 parts of soybean lecithin, 35~40 parts of methylene chloride, filler 30~35
Part, 25~30 parts of adhesive, 25~30 parts of additive, 40~50 parts of physiological saline.
Preferably, a kind of berberine powder liquid paste applied to direct pulp capping, the raw material including following parts by weight:
45 parts of berberine, 45 parts of ethyl alcohol, 38 parts of soybean lecithin, 38 parts of methylene chloride, 33 parts of filler, 28 parts of adhesive, additive
28 parts, 45 parts of physiological saline.
Preferably, the filler is one of microcrystalline cellulose, lactose, dextrin or mannitol or a variety of.
Preferably, described adhesive is that polyvinylpyrrolidone aqueous solution, gelatin, hydroxypropyl methyl cellulose or height take
For one of hydroxypropyl cellulose or a variety of.
Preferably, the additive is methanol dichloromethane mixed organic solvents, ethanol-acetone mixed organic solvents, second
One of alcohol acetonitrile mixed organic solvents, methanol-acetone mixed organic solvents are a variety of.
The invention also provides a kind of preparation methods of berberine powder liquid paste applied to direct pulp capping, including following step
It is rapid:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and 35~50 DEG C of heating obtains berberine second
Alcoholic solution；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin is mixed to get
Lipoprotein solution；
S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer, wherein the coptis
The mass ratio of element and soybean lecithin is 1:2~8；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and adds
Heat is stirred evenly to 40~70 DEG C, and natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
In the present invention, a kind of berberine powder liquid paste applied to direct pulp capping has a variety of oral cavity common bacterias bright
Aobvious inhibiting effect, while berberine can play anti-inflammatory effect in different histocytes, and p38 MAPK can be blocked to believe
Number access reduces the secretion of IL-2 after phytohemagglutinin (PHA) processing jurkat cell.Berberine can block NF- κ b
Signal path inhibits the inflammatory reaction of 264.7 macrophage of RAW of lipopolysaccharides (LPS) induction.It is worth noting that berberine
P38 MAPK and NF- κ b signal path can be blocked simultaneously, the mast cell inflammatory reaction for inhibiting IL-33 to mediate；Inhibit cardiac muscle
Inflammatory reaction and apoptosis when cellular damage.The present invention has antibacterial, anti-inflammatory, induced osteogenesis triple function, makes it have reparation
The application potential of inflamed human dental pulp, is worthy to be popularized.
Specific embodiment
Combined with specific embodiments below the present invention is made further to explain.
Embodiment one
The present embodiment proposes a kind of berberine powder liquid paste applied to direct pulp capping, the original including following parts by weight
Material: 30 parts of berberine, 30 parts of ethyl alcohol, 30 parts of soybean lecithin, 30 parts of methylene chloride, 25 parts of filler, 20 parts of adhesive, addition
20 parts of agent, 30 parts of physiological saline；
Preparation method includes the following steps:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and it is molten that 35 DEG C of heating obtains berberine ethyl alcohol
Liquid；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin is mixed to get
Lipoprotein solution；
S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer, wherein the coptis
The mass ratio of element and soybean lecithin is 1:2；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and adds
Heat is stirred evenly to 40 DEG C, and natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
Embodiment two
The present embodiment proposes a kind of berberine powder liquid paste applied to direct pulp capping, the original including following parts by weight
Material: 40 parts of berberine, 40 parts of ethyl alcohol, 35 parts of soybean lecithin, 35 parts of methylene chloride, 30 parts of filler, 25 parts of adhesive, addition
25 parts of agent, 40 parts of physiological saline；
Preparation method includes the following steps:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and it is molten that 40 DEG C of heating obtains berberine ethyl alcohol
Liquid；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin is mixed to get
Lipoprotein solution；
S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer, wherein the coptis
The mass ratio of element and soybean lecithin is 1:4；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and adds
Heat is stirred evenly to 50 DEG C, and natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
Embodiment three
The present embodiment proposes a kind of berberine powder liquid paste applied to direct pulp capping, the original including following parts by weight
Material: 50 parts of berberine, 50 parts of ethyl alcohol, 40 parts of soybean lecithin, 40 parts of methylene chloride, 35 parts of filler, 30 parts of adhesive, addition
30 parts of agent, 55 parts of physiological saline；
Preparation method includes the following steps:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and it is molten that 45 DEG C of heating obtains berberine ethyl alcohol
Liquid；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin is mixed to get
Lipoprotein solution；
S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer, wherein the coptis
The mass ratio of element and soybean lecithin is 1:6；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and adds
Heat is stirred evenly to 60 DEG C, and natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
Example IV
The present embodiment proposes a kind of berberine powder liquid paste applied to direct pulp capping, the original including following parts by weight
Material: 60 parts of berberine, 60 parts of ethyl alcohol, 45 parts of soybean lecithin, 45 parts of methylene chloride, 40 parts of filler, 35 parts of adhesive, addition
35 parts of agent, 60 parts of physiological saline；
Preparation method includes the following steps:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and it is molten that 50 DEG C of heating obtains berberine ethyl alcohol
Liquid；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, soybean lecithin is mixed to get
Lipoprotein solution；
S3: berberine ethanol solution is added in soybean lecithin solution, and evaporation obtains phospholipid monolayer, wherein the coptis
The mass ratio of element and soybean lecithin is 1:8；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and adds
Heat is stirred evenly to 70 DEG C, and natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (7)
1. a kind of berberine powder liquid paste applied to direct pulp capping, which is characterized in that the raw material including following parts by weight: the coptis
30~60 parts of element, 30~45 parts of soybean lecithin, 30~45 parts of methylene chloride, 25~40 parts of filler, glues 30~60 parts of ethyl alcohol
20~35 parts of mixture, 20~35 parts of additive, 30~60 parts of physiological saline.
2. a kind of berberine powder liquid paste applied to direct pulp capping according to claim 1, which is characterized in that including with
The raw material of lower parts by weight: 40~50 parts of berberine, 40~50 parts of ethyl alcohol, 35~40 parts of soybean lecithin, methylene chloride 35~40
Part, 30~35 parts of filler, 25~30 parts of adhesive, 25~30 parts of additive, 40~50 parts of physiological saline.
3. a kind of berberine powder liquid paste applied to direct pulp capping according to claim 1, which is characterized in that including with
The raw material of lower parts by weight: 45 parts of berberine, 38 parts of soybean lecithin, 38 parts of methylene chloride, 33 parts of filler, glues 45 parts of ethyl alcohol
28 parts of mixture, 28 parts of additive, 45 parts of physiological saline.
4. a kind of berberine powder liquid paste applied to direct pulp capping according to claim 1, which is characterized in that described to fill out
Filling agent is one of microcrystalline cellulose, lactose, dextrin or mannitol or a variety of.
5. a kind of berberine powder liquid paste applied to direct pulp capping according to claim 1, which is characterized in that described viscous
Mixture is one in polyvinylpyrrolidone aqueous solution, gelatin, hydroxypropyl methyl cellulose or Hydroxypropylcelliloxe
Kind is a variety of.
6. a kind of berberine powder liquid paste applied to direct pulp capping according to claim 1, which is characterized in that described to add
Adding agent is methanol dichloromethane mixed organic solvents, ethanol-acetone mixed organic solvents, ethyl alcohol acetonitrile mixed organic solvents, first
One of alcohol-acetone mixed organic solvents are a variety of.
7. a kind of preparation side of the berberine powder liquid paste according to claim 1-6 applied to direct pulp capping
Method, which comprises the following steps:
S1: the berberine of above-mentioned parts by weight is dissolved in the ethyl alcohol, and it is molten that 35~50 DEG C of heating obtains berberine ethyl alcohol
Liquid；
S2: the soybean lecithin of above-mentioned parts by weight is dissolved in the methylene chloride, it is molten to be mixed to get soybean lecithin
Liquid；
S3: berberine ethanol solution is added in soybean lecithin solution, evaporation obtain phospholipid monolayer, wherein berberine with
The mass ratio of soybean lecithin is 1:2~8；
S4: sequentially adding filler, adhesive, additive in obtained phospholipid monolayer, adds physiological saline and is heated to
It 40~70 DEG C, stirs evenly, natural cooling obtains the berberine powder liquid paste applied to direct pulp capping.
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| CN201910351167.5A CN109908001A (en) | 2019-04-28 | 2019-04-28 | A kind of berberine powder liquid paste and preparation method thereof applied to direct pulp capping |
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| CN201910351167.5A CN109908001A (en) | 2019-04-28 | 2019-04-28 | A kind of berberine powder liquid paste and preparation method thereof applied to direct pulp capping |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012780A (en) * | 2019-12-23 | 2020-04-17 | 青岛市口腔医院 | Application of berberine in preventing and treating pulpitis |
| CN114028239A (en) * | 2021-11-22 | 2022-02-11 | 河南大学 | Root canal disinfection paste and preparation method thereof |
Citations (3)
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|---|---|---|---|---|
| US5856487A (en) * | 1996-02-14 | 1999-01-05 | National Institute Of Immunology | Application of protoberberine alkaloid, berberine, an immunosuppressive agent |
| CN104940167A (en) * | 2015-06-05 | 2015-09-30 | 厦门大学 | Preparation method for berberine-loaded phospholipid composite nanoparticles |
| CN107898647A (en) * | 2017-10-31 | 2018-04-13 | 常州豪坦商贸有限公司 | One kind promotees tissue activity's type pulp-cap and preparation method thereof |
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2019
- 2019-04-28 CN CN201910351167.5A patent/CN109908001A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5856487A (en) * | 1996-02-14 | 1999-01-05 | National Institute Of Immunology | Application of protoberberine alkaloid, berberine, an immunosuppressive agent |
| CN104940167A (en) * | 2015-06-05 | 2015-09-30 | 厦门大学 | Preparation method for berberine-loaded phospholipid composite nanoparticles |
| CN107898647A (en) * | 2017-10-31 | 2018-04-13 | 常州豪坦商贸有限公司 | One kind promotees tissue activity's type pulp-cap and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 徐爱凤等: "黄连素复合生物膜作小型猪牙直接盖髓的组织学观察", 《实用口腔医学杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012780A (en) * | 2019-12-23 | 2020-04-17 | 青岛市口腔医院 | Application of berberine in preventing and treating pulpitis |
| CN114028239A (en) * | 2021-11-22 | 2022-02-11 | 河南大学 | Root canal disinfection paste and preparation method thereof |
| CN114028239B (en) * | 2021-11-22 | 2023-04-18 | 河南大学 | Root canal disinfection paste and preparation method thereof |
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Application publication date: 20190621 |