CN109879779A - A kind of novel processing step of diaryl ether compound object and its application - Google Patents
A kind of novel processing step of diaryl ether compound object and its application Download PDFInfo
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- CN109879779A CN109879779A CN201910181094.XA CN201910181094A CN109879779A CN 109879779 A CN109879779 A CN 109879779A CN 201910181094 A CN201910181094 A CN 201910181094A CN 109879779 A CN109879779 A CN 109879779A
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Abstract
The present invention relates to a kind of novel processing step of diaryl ether compound object, compound 1 is specifically sequentially added into reactor, dimethyl sulfoxide, cesium carbonate, compound 2 is stirred at room temperature 10-60 minutes；Being subsequently placed in reaction temperature is in the oil bath pan for be set as 70-120 DEG C, and is irradiated with incandescent lamp, and reaction process is detected by TLC, to after the reaction was completed, reaction solution is chromatographed through filtering, extraction and column, obtains target compound, completes the preparation of diaryl ether compound object.Technical solution of the present invention does not add any transition-metal catalyst and ligand or photoredox agent under visible light-inducing, and photocatalysis C-O cross-coupling reaction occurs for aryl halide and phenol derivatives.Preparation method mild condition, green, it is efficiently, at low cost, it is easy to operate.Such prepared compound is biology, medicine, important synthetic intermediate of the organic synthesis field especially in terms of pharmaceutical synthesis.
Description
Technical field
The present invention relates to the novel processing steps and its application example of a kind of diaryl ether compound object.
Background technique
Diaryl ether compound object played an important role in organic synthesis field for many years, while be also medicine, agriculture
The important synthetic intermediate of medicine etc..Some organic compounds being made of diaryl ether unit such as antibiotic vancomycin and
HIV antibiotic has been demonstrated there is apparent bioactivity.However, traditional synthetic method of diaryl ether intermediate exists
It is at high cost, it is inefficient, the deficiencies of complex operation.Therefore seek a kind of novel, easy to operate and efficient synthesis side
Method is imperative.
Summary of the invention
The invention patent proposes a kind of mild condition, efficiently, the new method of synthesis of diaryl ethers compound.The party
Method does not need any transition-metal catalyst and ligand or photoredox agent, the aryl halide being only catalyzed under visible light-inducing
C-O cross-coupling reaction occurs between compound and fortified phenol, it can realize that diaryl ether compound object is efficiently prepared.
It is a primary object of the present invention to overcome the high cost of conventional synthesis diaryl ether compound object, one is provided
Kind does not need any transition-metal catalyst and ligand or photoredox agent, it is only necessary to the diaryl ethers of visible light-inducing
The green synthesis method of compound.
Technical scheme is as follows:
A kind of novel processing step of diaryl ether compound object, which is characterized in that the reaction equation is
Wherein, any transition-metal catalyst had not both been needed, ligand and photoredox agent are not needed yet, it is only necessary to is incandescent
Reaction can be completed under light irradiation.
It the described method comprises the following steps:
(1) compound 1 is sequentially added into reactor, dimethyl sulfoxide, cesium carbonate, compound 2 is stirred at room temperature
10-60 minutes；
(2) being subsequently placed in reaction temperature is in the oil bath pan for be set as 70-120 DEG C, and is irradiated with incandescent lamp, reaction process
It is detected by TLC, to which after the reaction was completed, reaction solution obtains target compound, completion diaryl ether through filtering, extraction and column chromatography
The preparation of class compound.
The substituent R1For 4- cyano, 4- nitro, 4- ethyl ketone base, R2For 4- chlorine, 4- hydrogen, 2- chlorine, 4- methyl, 3- first
Base, 4- methoxyl group, any one in 4- nitro substituted aryl, X is any one in bromine and iodine.
The compound 1, compound 2, the molar ratio of alkali are 1:0.5-6:0.5-6.
The whipping temp of the step (1) is room temperature；The reaction temperature of step (2) is 80 DEG C.
The solvent of the step (1) is one of dimethyl sulfoxide and n,N-Dimethylformamide, preferably dimethyl
Sulfoxide.The alkali of the step (1) is preferably inorganic base cesium carbonate.
The present invention has the beneficial effect that:
Present invention firstly discloses a kind of novel processing steps of diaryl ether compound object.This method does not need any mistake
Metallic catalyst and ligand or photoredox agent are crossed, the aryl halide and fortified phenol being only catalyzed under visible light-inducing
Between occur C-O cross-coupling reaction, it can realize diaryl ether compound object efficiently prepare.
Technical solution of the present invention utilizes Photocatalysis, the novel method for synthesizing of synthesis of diaryl ethers compound.It should
Method is at low cost, easy to operate.
The present invention provides the application examples of the novel processing step of diaryl ether compound object.Two synthesized with this method
Aryl ethers compounds yield and purity are preferable.
Specific embodiment
The present invention is further illustrated below with reference to embodiment, but the scope of protection of present invention is not limited to implement
The range of example statement.
Instrument and reagent:
Fusing point is measured with X4 type melting point apparatus (production of Beijing third optical instrument factory), and thermometer is not calibrated；1H NMR and13600 type 600MHz core of C NMR 400 type 400MHz Nuclear Magnetic Resonance of Varian Mercury or Varian Mercury
Magnetic resonance device measurement, deuterated chloroform (CDCl3) or deuterated dimethyl sulfoxide (DMSO-d6) it is solvent, TMS is internal standard；SHZ-E type
Circulating water type vacuum pump (the biochemical instrument plant of Shanghai Rong Ya)；DZE-6120 type vacuum oven (Shanghai perseverance day scientific instrument system
Make company)；WRS-1A numeral melting point instrument (Shanghai Suoguang Optoelectronic Technology Co., Ltd.)；EB2005A electronic balance；ZF-I type three is used
Uv analyzer；DE-102J heat collecting type constant-temperature heating magnetic stirring apparatus (grey hair chemical apparatuses factory, Gongyi City)；DFX-5L/30 is low
(hundred river instrument plant of Wuxi City) is bathed in warm isothermal reaction；2YZ-4A type rotary vane type vacuum oil pump (Linhai City Yong Hao vacuum equipment factory).
Substituted benzene phenols (AR), dimethyl sulfoxide (AR), substituted aryl halogen class (AR), petroleum ether (AR), ethyl acetate (AR) are industrial
Nitrogen (AR).
Embodiment 1
A method of preparing 4- cyano-diaryl ether (4-phenoxybenzonitrile) 3a, including following experiment step
It is rapid:
Compound 4- cyano iodobenzene 1a (0.23g, 1.0mmol, 1.0eqv.), DMSO are sequentially added into reactor
(3ml),Cs2CO3(0.65g, 2.0mmol, 2.0eqv.), phenol 2a (0.113g, 1.2mmol, 1.2eqv.) are stirred under room temperature
10 minutes.It is subsequently placed in 80 DEG C of oil bath pans, reacts 10h under light illumination, TLC is detected after the reaction was completed, and reaction solution is filtered, extracted
It takes and is chromatographed with column, obtain target product 3a, yield 79%.
1H NMR(CDCl3, 400MHz) δ (ppm) 7.60 (d, J=8.0Hz, 2H, Ar-H), 7.44-7.40 (m, 2H, Ar-
H),7.26-7.23(m,1H,Ar-H),7.08(m,2H,Ar-H),7.00(m,2H,Ar-H)；
13C NMR(101MHz,CDCl3)δ161.71,154.81,139.29,134.29,134.18,130.29,
125.21,122.46,120.47,118.92,118.19,117.93,105.80.
Embodiment 2
Compound 4- cyano iodobenzene 1a (2.3g, 10mmol, 1.0eqv.), DMSO (30ml) are sequentially added into reactor,
Cs2CO3(6.5g, 20mmol, 2.0eqv.), phenol 2a (1.13g, 12mmol, 1.2eqv.) are stirred 10 minutes under room temperature.Then
It being placed in 80 DEG C of oil bath pans, reacts 10h under light illumination, TLC is detected after the reaction was completed, and reaction solution is chromatographed through filtering, extraction and column,
Obtain target product 3a, yield 76%.
Embodiment 3
Compound 4- cyano iodobenzene 1a (0.023g, 0.10mmol, 1.0eqv.), DMSO are sequentially added into reactor
(0.3ml),Cs2CO3(0.065g, 0.20mmol, 2.0eqv.), phenol 2a (0.0113g, 0.12mmol, 1.2eqv.), room temperature
Lower stirring 10 minutes.It is subsequently placed in 80 DEG C of oil bath pans, reacts 10h under light illumination, TLC is detected after the reaction was completed, reaction solution warp
Filtering, extraction and column chromatography, obtain target product 3a, yield 83%.
Embodiment 4
A kind of side preparing 4- cyano -4 '-chlorine diaryl ether (4- (4-chlorophenoxy) benzonitrile) 3b
Method, including following experimental procedure:
Compound 4- cyano iodobenzene 1a (1.0mmol, 1.0eqv.), DMSO (3ml), Cs are sequentially added into reactor2CO3
(2.0mmol, 2.0eqv.), 4- chlorophenol 2b (1.2mmol, 1.2eqv.) are stirred 10 minutes under room temperature.It is subsequently placed in 80 DEG C of oil
In bath, 10h is reacted under light illumination, and TLC is detected after the reaction was completed, and reaction solution is chromatographed through filtering, extraction and column, obtains target production
Object 3b, yield 66%.
Embodiment 5
It is a kind of to prepare 4- nitro -3 '-methyl diaryl ether (1-methyl-3- (4-nitrophenoxy) benzene) 3c
Method, including following experimental procedure:
Compound 4- nitro iodobenzene 1c (1.0mmol, 1.0eqv.), DMSO (3ml), Cs are sequentially added into reactor2CO3
(2.0mmol, 2.0eqv.), 3- methylphenol 2c (1.2mmol, 1.2eqv.) are stirred 10 minutes under room temperature.It is subsequently placed in 80 DEG C
In oil bath pan, 10h is reacted under light illumination, and TLC is detected after the reaction was completed, and reaction solution is chromatographed through filtering, extraction and column, obtains target
Product 3c, yield 85%.
Embodiment 6
It is a kind of to prepare 4- acetyl group -4 '-methoxyl group diaryl ether (1- (4- (4-methoxyphenoxy) phenyl)
Ethanone) the method for 3d, including following experimental procedure:
Compound 4- acetyl group bromobenzene 1d (1.0mmol, 1.0eqv.), DMSO (3ml) are sequentially added into reactor,
Cs2CO3(2.0mmol, 2.0eqv.), 4- metoxyphenol 2d (1.2mmol, 1.2eqv.) are stirred 10 minutes under room temperature.Then
It being placed in 80 DEG C of oil bath pans, reacts 10h under light illumination, TLC is detected after the reaction was completed, and reaction solution is chromatographed through filtering, extraction and column,
Obtain target product 3d, yield 86%.
The above embodiments are only the preferred technical solution of the present invention, and are not construed as limitation of the invention, this Shen
Please in embodiment and embodiment in feature in the absence of conflict, can mutual any combination.Protection model of the invention
The technical solution that should be recorded with claim is enclosed, the equivalent replacement side of technical characteristic in the technical solution recorded including claim
Case is protection scope.Equivalent replacement i.e. within this range is improved, also within protection scope of the present invention.
Claims (6)
1. a kind of preparation method of diaryl ether compound object, which is characterized in that the reaction equation are as follows:
It the described method comprises the following steps:
(1) compound 1 is sequentially added into reactor, dimethyl sulfoxide, cesium carbonate, 10-60 is stirred at room temperature in compound 2
Minute；
(2) being subsequently placed in reaction temperature is in the oil bath pan for be set as 70-120 DEG C, and is irradiated with incandescent lamp, reaction process by
TLC detection, to which after the reaction was completed, reaction solution obtains target compound, completion diaryl ethers through filtering, extraction and column chromatography
The preparation of compound.
2. the preparation method of diaryl ether compound object according to claim 1, which is characterized in that the substituent R1
For 4- cyano, 4- nitro or 4- ethyl ketone base, R2It is taken for 4- chlorine, 4- hydrogen, 2- chlorine, 4- methyl, 3- methyl, 4- methoxyl group, 4- nitro
For any one in aryl, X is any one in bromine and iodine.
3. the preparation method of diaryl ether compound object according to claim 1, which is characterized in that in the step (1)
Compound 1, compound 2, the molar ratio of alkali are 1:0.5-6:0.5-6.
4. the preparation method of diaryl ether compound object according to claim 1, it is characterised in that: the step (1)
Whipping temp is room temperature；The reaction temperature of step (2) is 80 DEG C.
5. the preparation method of diaryl ether compound object according to claim 1, it is characterised in that: the step (1)
Solvent is one of dimethyl sulfoxide and n,N-Dimethylformamide, preferably dimethyl sulfoxide.
6. the preparation method of diaryl ether compound object according to claim 1, it is characterised in that: the step (1)
Alkali is inorganic base cesium carbonate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156634A (en) * | 2019-05-09 | 2019-08-23 | 三峡大学 | A kind of preparation method of diaryl ether compound object |
| CN112125840A (en) * | 2020-08-11 | 2020-12-25 | 河南师范大学 | Based on CO2Method for preparing diaryl ether compound by participated C-F bond activation |
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| CN105001029A (en) * | 2015-05-25 | 2015-10-28 | 常州大学 | Method for synthesizing photocatalysis diaryl ether derivative |
| CN107540691A (en) * | 2016-06-23 | 2018-01-05 | 上海药明康德新药开发有限公司 | Using diaryl ether as Macrocyclic lactams compound of skeleton and preparation method thereof |
| CN108440251A (en) * | 2018-02-08 | 2018-08-24 | 陕西师范大学 | A kind of method of light/nickel concerted catalysis list arylation glycol |
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| CN105001029A (en) * | 2015-05-25 | 2015-10-28 | 常州大学 | Method for synthesizing photocatalysis diaryl ether derivative |
| CN107540691A (en) * | 2016-06-23 | 2018-01-05 | 上海药明康德新药开发有限公司 | Using diaryl ether as Macrocyclic lactams compound of skeleton and preparation method thereof |
| CN108440251A (en) * | 2018-02-08 | 2018-08-24 | 陕西师范大学 | A kind of method of light/nickel concerted catalysis list arylation glycol |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110156634A (en) * | 2019-05-09 | 2019-08-23 | 三峡大学 | A kind of preparation method of diaryl ether compound object |
| CN112125840A (en) * | 2020-08-11 | 2020-12-25 | 河南师范大学 | Based on CO2Method for preparing diaryl ether compound by participated C-F bond activation |
| CN112125840B (en) * | 2020-08-11 | 2021-10-15 | 河南师范大学 | Based on CO2Method for preparing diaryl ether compound by participated C-F bond activation |
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