CN109875607A - Infiltrate tissue testing method, apparatus and system - Google Patents
Infiltrate tissue testing method, apparatus and system Download PDFInfo
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Abstract
The invention discloses infiltration tissue testing methods, apparatus and system, this method comprises: obtaining the elastic information distribution map of biological tissue；Multiple observation points are chosen on elastic information distribution map；Obtain the difference of two observation point corresponding position elastic informations；Judge whether difference is greater than or equal to preset threshold；When difference is greater than or equal to preset threshold, determine between two observation points there is hard sign ring region.Tissue testing method, apparatus and system are infiltrated provided by the embodiment of the present invention, by choosing multiple observation points on the elastic information distribution map of biological tissue, judge whether the difference of two observation point corresponding position elastic informations is greater than or equal to preset threshold, when difference is greater than or equal to preset threshold, it determines between the two observation points there is hard sign ring region, and then the distribution map of hard sign ring region can be drawn according to the judgment result.The detection method, which is not operated level by elastic information detection range and testing staff, to be influenced, therefore testing result is more reliable.
Description
Technical field
The present invention relates to ultrasonic detecting technology fields, and in particular to infiltration tissue testing method, apparatus and system.
Background technique
The mechanical characteristic of biological tissue necessarily includes the health and fitness information of biological tissue, for example, normal bio tissue is softer,
Its elasticity is smaller, and occurs that the biological tissue that pathology sexually revises is then harder, and elasticity is larger, or even shape occur early in pathological tissues
Before state changes, hardness just has occurred and that variation, leads between normal bio tissue and pathological tissues that there are biggish elasticity
Difference.On the other hand, for infiltrative growth, (infiltrative growth refers to tumour cell to one of key property of malignant tumour in clinic
The growth pattern of surrounding tissue (including tissue space, lymphatic vessel or blood vessel) is grown into and destroys, malignant tumour is in that wellability is raw more
Long, generally without envelope, with normal adjacent tissue without obvious boundary), ultrasound clinic Findings are that lesion edge is unobvious, not only
It is whole and high echo occur dizzy etc..Its pathologic basis is that cancerous tissue is directly infiltrated to peripheral adipose tissue, and it is thin adipose tissue, cancer occur
Born of the same parents and interfibrillar substance mix (as shown in Figure 1A), form neither too hard, nor too soft annular region, or because cancerous tissue infiltrates, cause
Surrounding annulus connective tissue reactive hyperplasia, constitutes caused by irregular interface.Generally, wellability is as pernicious swollen
One of feature of tumor can be used as clinical imageology and judge good pernicious lesion and classification (grading) of malignant tumour and by stages
(staging) one of specific index: clinical imaging methods detect that the appearance of tissue infiltration's phenomenon statistically may be used
To promote a possibility that lesion is pernicious lesion at this；There is not tissue infiltration's phenomenon similarly to will increase lesion at this being benign
A possibility that lesion (as shown in Figure 1B, boundary finishing, rule between benign tumour and normal bio tissue, clear).It is worth
It is noted that existing literature proposes that infiltration phenomenon has statistical significance as specific index, doctor can be assisted to lesion
It is analyzed, promotes diagnosis confidence, but due to the factors such as the anisotropic and complicated biological tissue of human body environment of human body, infiltration
Property be not lesion analysis and judgement absolute index, such as lump expansive growth compressing surrounding tissue caused by tension increase,
It is also possible to that clinical medicine diagnostic imaging is caused to find " wellability " phenomenon.In ultrasonic imaging field, by organization ultrasonic elastic graph
The phenomenon that elastic information that the edge ring-type characteristic area of lesion occurs as in increases extremely referred to as " sign ring firmly " (English:
Stiff Rim), usual clinical interpretation is Malignant mass edge not finishing, and form is irregular, if shearing wave elastogram occurs
" hard ring sign " often prompt lump is in infiltrative growth, and it is surrounding tissue caused by lump infiltrative growth that sign, which forms pathologic basis,
Reactive fibre hyperblastosis, causes hardness to increase.As shown in Fig. 2, upper figure is the elastic information distributed image of tissue, show
Hard sign ring phenomenon, wherein the white in circular dashed line be brighter areas (original image be it is colored, upper figure right legend item from it is upper it
Under be followed successively by the red gradient color to blue, legend top half shows brighter) to be formed by ring as hard for the brighter areas
Levy ring.The following figure is to organize corresponding ultrasound image shown in figure thereon in Fig. 2, and it is abnormal to can show that tissue corresponding position has
Echo, but can not show the elastic information of tissue corresponding position.
The prior art determines in tissue whether have in the hard sign ring of detection often through the elastic information value of tissue visualization
There is hard sign ring.Since the normal elasticity information of different tissues is different, testing staff is needed to be adjusted according to specific situation when detecting
The detection range of elastic information.
Inventors have found that the factors such as set elastic information detection range and testing staff's operation level are to testing result
It is affected, so that above-mentioned detection method is unreliable.For example, when setting elastic information detection range as 0-180kPa,
The elastic information distributed image observed for a certain tissue X is as shown in the upper figure of Fig. 3 A, and wherein the white in circular dashed line is
(original image is colour to brighter areas, and upper figure right legend item is from being followed successively by the red gradient color to blue under upper, on legend item
Half part shows brighter) to be formed by ring be hard sign ring to the brighter areas, and the following figure is that tissue X shown in figure is corresponding thereon in Fig. 3 A
Ultrasound image；When setting elastic information detection range as 0-65kPa, the elastic information that is observed for same tissue X
Distributed image is as shown in the upper figure of Fig. 3 B, and wherein the white in circular dashed line is that (original image is colored, upper figure right figure to brighter areas
Example item shows brighter from the red gradient color to blue, legend top half is followed successively by under upper) brighter areas formed
Ring be hard sign ring, the following figure is the corresponding ultrasound image of tissue X shown in figure thereon in Fig. 3 B.It can be seen by Fig. 3 A and Fig. 3 B
Out, the setting of elastic information detection range is different, so that elastic information distributed image difference is larger, this will lead to hard sign ring may
It shows unobvious and is easy ignored on elastic information image.
Summary of the invention
In view of this, the embodiment of the invention provides infiltration tissue testing methods, apparatus and system, to solve existing detection
Method is by the problem of being affected of factors such as set elasticity modulus detection range and testing staff's operation level.
According in a first aspect, the embodiment of the invention provides a kind of infiltration tissue testing methods, comprising: obtain biological tissue
Elastic information distribution map；Multiple observation points are chosen on the elastic information distribution map；Obtain two observation point corresponding positions
Locate the difference of elastic information；Judge whether the difference is greater than or equal to preset threshold；Described in being greater than or equal to when the difference
When preset threshold, determine between described two observation points there is hard sign ring region.
Optionally, described the step of choosing multiple observation points on the elastic information distribution map, comprising: in the elasticity
Multiple observation points are chosen along a plurality of parallel straight line on information distributing plan.
Optionally, the step of elastic information distribution map for obtaining biological tissue, comprising: obtain observation point corresponding position
The elasticity modulus that place is motivated about the first predetermined angular；It is motivated about the first predetermined angular the acquisition observation point corresponding position
Elasticity modulus the step of include: that control arrayed ultrasonic probe emits predetermined ultrasonic signal towards biological tissue and obtains first
Ultrasound echo signal；Control first pulse excitation of the arrayed ultrasonic probe generation with biological tissue surface in the first predetermined angular
To generate thrust to biological tissue, biological tissue generates and the first pulse excitation wave beam wave beam under the thrust
The vertical shearing wave in direction；And it controls arrayed ultrasonic probe and emits the predetermined ultrasonic signal towards biological tissue and obtain the
Two ultrasound echo signals；It is calculated according to first ultrasound echo signal and second ultrasound echo signal more in biological tissue
The first spread speed of shearing wave of a observation point corresponding position；Observation point, which is calculated, according to the first spread speed of shearing wave corresponds to position
Set the elasticity modulus that place is motivated about first predetermined angular.
Optionally, it when choosing multiple observation points on the elastic information distribution map, hangs down with pulse excitation beam direction
Multiple observation points are chosen in straight a plurality of rectilinear direction.
Optionally, the step of elastic information distribution map for obtaining biological tissue, further includes: obtain observation point and correspond to position
Set the elasticity modulus that place is motivated about at least one second predetermined angular；The acquisition observation point corresponding position is about at least one
The step of elasticity modulus of a second predetermined angular excitation includes: to control arrayed ultrasonic probe and generate with biological tissue surface to be in
Second pulse excitation wave beam of the second predetermined angular is to generate thrust to biological tissue, and biological tissue is under the thrust
Generate the shearing wave vertical with the second pulse excitation beam direction；And it controls arrayed ultrasonic probe and is sent out towards biological tissue
It penetrates the predetermined ultrasonic signal and obtains third ultrasound echo signal；It is super according to first ultrasound echo signal and the third
Sound echo-signal calculates the second spread speed of shearing wave of multiple observation points in biological tissue；According to the second spread speed of shearing wave
The elasticity modulus of calculating observation point.
Optionally, it is described obtain biological tissue elastic information distribution map the step of, further includes: by observation point with it is multiple
The corresponding multiple elasticity modulus of predetermined angular synthesize an elasticity modulus, thus will multiple elasticity corresponding with multiple predetermined angulars
Modulus distribution map synthesizes an elasticity modulus distribution map.
According to second aspect, the embodiment of the invention provides a kind of infiltration tissue detection devices, comprising: first obtains list
Member, for obtaining the elastic information distribution map of biological tissue；Selection unit is more for choosing on the elastic information distribution map
A observation point；Second acquisition unit, for obtaining the difference of two observation point corresponding position elastic informations；Judging unit is used
In judging whether the difference is greater than or equal to preset threshold；Determination unit, for when the difference is more than or equal to described pre-
If when threshold value, determining between described two observation points there is hard sign ring region.
According to the third aspect, the embodiment of the invention provides a kind of electronic equipment, comprising: memory and processor, it is described
Connection is communicated with each other between memory and the processor, computer instruction is stored in the memory, and the processor is logical
It crosses and executes the computer instruction, thereby executing infiltration tissue detection described in first aspect or its any optional embodiment
Method.
According to fourth aspect, the embodiment of the invention provides a kind of computer readable storage mediums, which is characterized in that described
Computer-readable recording medium storage has computer instruction, and the computer instruction is for making the computer execute first aspect
Or infiltration tissue testing method described in its any optional embodiment.
According to the 5th aspect, the embodiment of the invention provides a kind of infiltration tissue detection systems, comprising: ultrasonic probe is used
Ultrasonic beam and ultrasonic echo is received in generating according to instruction；Electronic equipment described in the third aspect.
Tissue testing method, apparatus and system are infiltrated provided by the embodiment of the present invention, pass through the elasticity in biological tissue
Multiple observation points are chosen on information distributing plan, judge whether the difference of two observation point corresponding position elastic informations is greater than or waits
In preset threshold, when difference is greater than or equal to preset threshold, determine between the two observation points there is hard sign ring region, in turn
The distribution map of hard sign ring region can be drawn according to the judgment result.The detection method is not by elastic information detection range and detection
Personnel operate horizontal influence, therefore testing result is more reliable.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Figure 1A shows malignant tumour wellability and increases the hard sign ring schematic diagram to be formed；
Figure 1B shows the schematic diagram of being not wetted by property of benign tumour growth；
Fig. 2 shows a biological tissue elasticity information distributing plan pictures and its corresponding ultrasound image with hard sign ring；
Fig. 3 A and Fig. 3 B are shown for same biological tissue, and elasticity when different detection ranges is arranged in existing detection method
Information distributing plan picture and its corresponding ultrasound image；
Fig. 4 shows lesion, levies ring region, the elastic information of normal bio tissue variation schematic diagram firmly；
Fig. 5 A shows a kind of flow chart for infiltrating tissue testing method according to an embodiment of the present invention；
Fig. 5 B shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention；
Fig. 5 C shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention；
Fig. 5 D shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention；
Fig. 6 A shows the position view of selected observation point；
Fig. 6 B shows the sign ring region distribution map firmly of one kind according to determined by judging result；
Fig. 7 shows the schematic diagram that observation point is chosen along a plurality of parallel lines；
Fig. 8 A shows the schematic diagram that observation point is chosen on the straight line vertical with pulse excitation beam direction；
Fig. 8 B shows the position view of observation point selected by the choosing method according to Fig. 8 A；
Fig. 9 A shows the schematic diagram that control arrayed ultrasonic probe emits predetermined ultrasonic signal towards biological tissue；
Fig. 9 B shows control arrayed ultrasonic probe generation and biological tissue surface is in 90 ° of the first pulse excitation wave beam
To generate the schematic diagram of thrust to biological tissue；
Fig. 9 C shows control arrayed ultrasonic probe generation and biological tissue surface is in 120 ° of the first pulse excitation wave
Beam is to the schematic diagram to biological tissue's generation thrust；
Fig. 9 D shows control arrayed ultrasonic probe generation and biological tissue surface is in 60 ° of the first pulse excitation wave beam
To generate the schematic diagram of thrust to biological tissue；
Fig. 9 E is shown to close about three 90 ° of predetermined angulars, 120 °, 60 ° of pulse excitation wave beam and the opposite of shearing wave
It is schematic diagram；
Figure 10 A shows a kind of functional block diagram for infiltrating tissue detection device according to an embodiment of the present invention；
Figure 10 B shows the functional block diagram of another infiltration tissue detection device according to an embodiment of the present invention；
Figure 10 C shows the functional block diagram of another infiltration tissue detection device according to an embodiment of the present invention；
Figure 10 D shows the functional block diagram of another infiltration tissue detection device according to an embodiment of the present invention
Figure 11 shows the structural schematic diagram of a kind of electronic equipment according to an embodiment of the present invention.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those skilled in the art are not having
Every other embodiment obtained under the premise of creative work is made, shall fall within the protection scope of the present invention.
As shown in figure 4, normal bio tissue is often softer, elastic smaller, positioned at two observation points of normal bio tissue
Elasticity usually indifference or difference it is very small；Affected area is often harder, elasticity is larger, positioned at two observation points of affected area
The also usual indifference of elasticity or difference are very small；Due to levying ring firmly between normal bio tissue and lesion, elasticity is inevitable
Be from it is smaller be transitioned into it is biggish.Based on this, infiltration tissue testing method described herein is inventors herein proposed, it hereafter will be right
This method is described in detail.
Embodiment one
Fig. 5 A shows a kind of flow chart for infiltrating tissue testing method according to an embodiment of the present invention.This method can be used
In levying ring with the presence or absence of hard in detection biological tissue, to assist the diagnostic work of doctor.As shown in Figure 5A, this method includes such as
Lower step:
S101: the elastic information distribution map of biological tissue is obtained.
Elastic information in the application refers to the information that can be used in characterizing biological tissue elasticity, such as elasticity modulus is (again
Claim Young's modulus), Poisson's ratio etc..
For example, elastic information of the biological tissue at multiple positions can be obtained by the method for ultrasonic imaging, and then shape
At the elastic information distribution map of biological tissue.
S102: multiple observation points are chosen on elastic information distribution map.
Step S102 can be multiple observation points of any selection, such as A, B, C, D, E point chosen in Fig. 6 A, adjacent sight
Spacing between measuring point can be unequal；Alternatively, observation point can also be chosen along a plurality of parallel straight line, it is adjacent on straight line
Spacing is equal between two observation points, so that the observation point chosen is in array format, in order to more accurately draw hard sign ring
Regional distribution chart, as shown in Fig. 7 and Fig. 8 B.
S103: the difference of two observation point corresponding position elastic informations is obtained.
S104: judge whether difference is greater than or equal to preset threshold.When difference is greater than or equal to preset threshold, step is executed
Rapid S105；Otherwise, it determines ring region is levied there is no hard between two observation points, it can also be by other means into one under the situation
It walks and determines between two observation points with the presence or absence of hard sign ring region.
The preset threshold is a preset numerical value, and the preset threshold may be greater than positioned at normal bio tissue
The difference of elastic information at two interior observation points, and it is greater than the difference for being located at elastic information at two intralesional observation points
Value；Wherein, the corresponding actual range of two observation points selected in step 103 and above-mentioned two in normal bio tissue
Actual range between a observation point, positioned at two intralesional observation point values actual range it is identical.
S105: determine between two observation points there is hard sign ring region.
" there is hard sign ring region between two observation points " refers to, is located at hard sign ring region in the line of two observation points
It is interior or line to be at least partially disposed in hard sign ring region.
For example, in fig. 6, it is assumed that the elastic information at observation point A, B, C, D, E is distributed as 10,10,5,0,0, presets threshold
Value is 3, then can determine between observation point A and C, between A and D, between A and E, between B and C, between B and D, between B and E, C
It is construed as the presence of hard sign ring region between D, between C and E, and there is no hard between observation point A and B, between D and E
Levy ring region.It can determine that a kind of distribution map of hard sign ring region is as shown in Figure 6B according to the judgement, in fig. 6b, oblique line filling
Annular region indicate hard sign ring region.
Above-mentioned infiltration tissue testing method, by choosing multiple observation points on the elastic information distribution map of biological tissue,
Judge whether the difference of two observation point corresponding position elastic informations is greater than or equal to preset threshold, when difference is greater than or equal to
When preset threshold, determine between the two observation points there is hard sign ring region, and then hard sign can be drawn according to the judgment result
The distribution map of ring region.The detection method, which is not operated level by elastic information detection range and testing staff, to be influenced, therefore is examined
It is more reliable to survey result.
Embodiment two
Fig. 5 B shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention.This method can be with
For detecting with the presence or absence of hard sign ring in biological tissue, to assist the diagnostic work of doctor.As shown in Figure 5 B, this method includes
Following steps:
S201: the elasticity modulus that observation point corresponding position is motivated about the first predetermined angular is obtained.
Elasticity modulus in the application about predetermined angular excitation refers to, is in predetermined angular when applying with biological tissue surface
Thrust when, according to biological tissue's elasticity modulus that the spread speed of generated shearing wave calculates under thrust.
When applying thrust to biological tissue, the shearing wave vertical with thrust direction can be generated, the shearing wave is in different bullets
Property biological tissue in spread speed it is different, therefore the elasticity of biological tissue can be calculated according to shearing velocity of wave propagation.
Specifically, above-mentioned steps S201 is the following steps are included: control arrayed ultrasonic probe is pre- towards biological tissue's transmitting
Determine ultrasonic signal and obtains the first ultrasound echo signal (as shown in Figure 9 A)；Control the generation of arrayed ultrasonic probe and biological tissue
Surface (can also pass through Manual press to generate thrust to biological tissue in the first pulse excitation wave beam of the first predetermined angular
Or other modes generate thrust to biological tissue), biological tissue generates and the first pulse excitation beam direction under thrust
Vertical shearing wave (as shown in Figure 9 B, the first pulse excitation wave beam and biological tissue surface are in 90 °)；And control arrayed ultrasonic
Probe emits predetermined ultrasonic signal towards biological tissue and obtains the second ultrasound echo signal；According to the first ultrasound echo signal and
Second ultrasound echo signal calculates the first spread speed of shearing wave of multiple observation points in biological tissue；Finally, according to observation point
The first spread speed of shearing wave calculate observation point elasticity modulus.It calculates shearing velocity of wave propagation and further calculates elasticity
Modulus is any technique commonly known, and details are not described herein.
S202: multiple observation points are chosen on elasticity modulus distribution map.
The step can choose multiple observation points in a plurality of rectilinear direction vertical with pulse excitation beam direction, such as scheme
Shown in 8A and shown in Fig. 8 B, wherein n1, n2, n3 ... n10 indicate the position of each transducer unit in arrayed ultrasonic transducer
It sets.
S203: the difference of two observation point corresponding position elasticity modulus is obtained.
S204: judge whether difference is greater than or equal to preset threshold.When difference is greater than or equal to preset threshold, step is executed
Rapid S205；Otherwise, it determines ring region is levied there is no hard between two observation points, it can also be by other means into one under the situation
It walks and determines between two observation points with the presence or absence of hard sign ring region.
S205: determine between two observation points there is hard sign ring region.
Above-mentioned steps S202 to S205 specifically please refers to step S102 to S105 respectively, and details are not described herein.
Embodiment three
Fig. 5 C shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention.This method can be with
For detecting with the presence or absence of hard sign ring in biological tissue, to assist the diagnostic work of doctor.As shown in Figure 5 C, this method includes
Following steps:
S301: the elasticity modulus that observation point corresponding position is motivated about the first predetermined angular is obtained.
The step specifically refers to step S201, and details are not described herein.
S302: the elasticity modulus that observation point corresponding position is motivated about at least one second predetermined angular is obtained.
Step S302 obtains the elasticity modulus step and step that observation point corresponding position is motivated about the second predetermined angular
S301 is similar.Specifically, step S302 is the following steps are included: control arrayed ultrasonic probe is generated with biological tissue surface in the
Second pulse excitation wave beam of two predetermined angulars (can also pass through Manual press or its other party to generate thrust to biological tissue
Formula generates thrust to biological tissue), biological tissue generates and the second pulse excitation beam direction is vertical cuts under thrust
Cut wave；And it controls arrayed ultrasonic probe and emits predetermined ultrasonic signal towards biological tissue and obtain third ultrasound echo signal；
It is passed according to the shearing wave second that the first ultrasound echo signal and third ultrasound echo signal calculate multiple observation points in biological tissue
Broadcast speed；The elasticity modulus of observation point is calculated according to the second spread speed of shearing wave.
Step S301, which can be, obtains the elasticity modulus that observation point corresponding position is motivated about 90 °, and step S302 can be with
It is the elasticity modulus for obtaining observation point corresponding position and being motivated about 120 ° (i.e. first second predetermined angular), such as Fig. 9 C institute
Show；The elasticity modulus that observation point corresponding position is motivated about 60 ° (i.e. second second predetermined angular) is obtained again, such as Fig. 9 D institute
Show.Fig. 9 E shows the relativeness schematic diagram of pulse excitation wave beam about these three predetermined angulars, shearing wave.
Shearing wave elastogram is the spread speed according to shearing wave in biological tissue to obtain the elasticity of biological tissue
Modulus, but shearing wave is decayed quickly in biological tissue so that in a practical situation due to the too early dyingout of shearing wave and
Method is caused to fail；And shearing wave is then decayed faster in complicated hard sign ring, is detected to lesion and its tissue around
It is that after shearing wave passes through the hard sign ring and pathological tissues of structural constituent complexity, attenuating is become apparent from, will lead to and detect
Hard sign ring is imperfect, to be unable to judge accurately pathological tissues to the complete Infiltrating of all surrounding tissues.For example, in Fig. 3 B
Image shown in upper figure is obtained using pulse excitation wave beam shown in Fig. 9 B, can be become apparent from, the hard sign ring in Fig. 3 B
(far from pulse excitation wave beam) side has apparent notch.On the other hand, shearing wave is perpendicular to pulse excitation beam direction
Propagate, therefore the biological tissue elasticity modulus as the propagation condition of shearing wave obtained from by shear direction of wave travel more
Single influence, therefore the tissue elasticity information on single vector direction can only be obtained, and biological tissue has anisotropy, this
So that infiltration tissue testing method inaccuracy.Above-mentioned steps S301 and S302, respectively apply biological tissue from least two directions
Add thrust, so that the shear-wave direction in biological tissue is propagated along at least two directions, so that at least one situation
Shearing wave will not be too fast in side decaying of the sign ring firmly far from pulse excitation wave beam, so that hard sign detected by this method
Ring is more complete；On the other hand, the influence for also making testing result step shearing direction of wave travel more single, therefore can also
Improve the accuracy of detection method.
S303: multiple observation points are chosen on the elasticity modulus distribution map motivated about each predetermined angular.
S304: the difference of two observation point corresponding position elasticity modulus is obtained on each elasticity modulus distribution map.
S305: judge whether difference is greater than or equal to preset threshold.When difference is greater than or equal to preset threshold, step is executed
Rapid S306；Otherwise, it determines ring region is levied there is no hard between two observation points, it can also be by other means into one under the situation
It walks and determines between two observation points with the presence or absence of hard sign ring region.
S306: determine between two observation points there is hard sign ring region.
The elasticity modulus distribution map that above-mentioned steps S303 to S306 is motivated about each predetermined angular analyzes two observations
With the presence or absence of hard sign ring region between point, to draw out hard sign ring region on each elasticity modulus distribution map.Doctor can be with
It is diagnosed with reference to the hard sign ring region distribution situation on multiple elasticity modulus distribution maps.Above-mentioned steps S303 to S306 is specifically asked
Step S202 to S205 is referred to respectively, and details are not described herein.
Example IV
Fig. 5 D shows the flow chart of another infiltration tissue testing method according to an embodiment of the present invention.This method can be with
For detecting with the presence or absence of hard sign ring in biological tissue, to assist the diagnostic work of doctor.As shown in Figure 5 D, this method includes
Following steps:
S401: the elasticity modulus that observation point corresponding position is motivated about the first predetermined angular is obtained.
S402: the elasticity modulus that observation point corresponding position is motivated about at least one second predetermined angular is obtained.
Above-mentioned steps S401 and S402 specifically please refer to step S301 and S302, and details are not described herein.
S403: synthesizing an elasticity modulus for multiple elasticity modulus corresponding with multiple predetermined angulars at observation point, thus
Multiple elasticity modulus distribution maps corresponding with multiple predetermined angulars are synthesized into an elasticity modulus distribution map.
For example, by the first elasticity modulus corresponding with the first predetermined angular (such as 90 °) at observation point and the second predetermined angle
Spend (such as 120 °) corresponding second elasticity modulus, third elasticity modulus corresponding with third predetermined angular (such as 60 °) synthesis
One elasticity modulus, as the elasticity modulus at the observation point in the elasticity modulus distribution map after synthesis.Specific synthesis
Method can be the mode averaged, and perhaps weighting seeks the mode of draw value or can also seek the mode of maximum value (i.e.
By the maximum elasticity modulus as after synthesis of numerical value in the first elasticity modulus, the second elasticity modulus, third elasticity modulus), this
Apply to specific synthetic method without limitation.
S404: multiple observation points are chosen on elasticity modulus distribution map in post synthesis.
S405: the difference of two observation point corresponding position elasticity modulus is obtained.
S406: judge whether difference is greater than or equal to preset threshold.When difference is greater than or equal to preset threshold, step is executed
Rapid S407；Otherwise, it determines ring region is levied there is no hard between two observation points, it can also be by other means into one under the situation
It walks and determines between two observation points with the presence or absence of hard sign ring region.
S407: determine between two observation points there is hard sign ring region.
Above-mentioned steps S404 to S407 specifically please refers to step S202 to S205 respectively, and details are not described herein.
Embodiment five
Figure 10 A shows a kind of functional block diagram for infiltrating tissue detection device according to an embodiment of the present invention.The device can
For realizing infiltration tissue testing method described in embodiment one to example IV or its any optional embodiment.Such as
Shown in Figure 10 A, which includes first acquisition unit 10, selection unit 20, second acquisition unit 30, judging unit 40 and determines
Unit 50.
First acquisition unit 10 is used to obtain the elastic information distribution map of biological tissue.
Selection unit 20 on elastic information distribution map for choosing multiple observation points.
Second acquisition unit 30 is used to obtain the difference of two observation point corresponding position elastic informations.
Judging unit 40 is for judging whether difference is greater than or equal to preset threshold.
Determination unit 50 is used for when difference is greater than or equal to preset threshold, determines between two observation points there is hard sign ring
Region.
Above-mentioned infiltration tissue detection device, by choosing multiple observation points on the elastic information distribution map of biological tissue,
Judge whether the difference of two observation point corresponding position elastic informations is greater than or equal to preset threshold, when difference is greater than or equal to
When preset threshold, determine between the two observation points there is hard sign ring region, and then hard sign can be drawn according to the judgment result
The distribution map of ring region.The detection method, which is not operated level by elastic information detection range and testing staff, to be influenced, therefore is examined
It is more reliable to survey result.
As a kind of optional embodiment of the present embodiment, as shown in Figure 10 B, first acquisition unit 10 is for obtaining observation
The elasticity modulus that point corresponding position is motivated about the first predetermined angular.The first acquisition unit 10 includes the first acquisition subelement
11, second subelement 12, the first computation subunit 13 and the second computation subunit 14 are obtained.
First acquisition subelement 11 emits predetermined ultrasonic signal simultaneously towards biological tissue for controlling arrayed ultrasonic probe
Obtain the first ultrasound echo signal.
Second acquisition subelement 12 is generated with biological tissue surface for controlling arrayed ultrasonic probe in the first predetermined angle
To generate thrust to biological tissue, biological tissue generates and the first pulse first pulse excitation wave beam of degree under thrust
The shearing wave for motivating beam direction vertical；And it controls arrayed ultrasonic probe and emits predetermined ultrasonic signal towards biological tissue and obtain
Take the second ultrasound echo signal.
First computation subunit 13 is used to calculate biological group according to the first ultrasound echo signal and the second ultrasound echo signal
Knit the first spread speed of shearing wave of interior multiple observation point corresponding positions.
Second computation subunit 14 is used to calculate observation point corresponding position about the according to the first spread speed of shearing wave
The elasticity modulus of one predetermined angular excitation.
Still optionally further, as illustrated in figure 10 c, first acquisition unit 10 be also used to obtain observation point corresponding position about
The elasticity modulus of at least one second predetermined angular excitation.The first acquisition unit 10 further includes that third obtains subelement 15 and the
Three computation subunits 16.
Third obtains subelement 15 and generates with biological tissue surface for controlling arrayed ultrasonic probe in the second predetermined angle
To generate thrust to biological tissue, biological tissue generates and the second pulse second pulse excitation wave beam of degree under thrust
The shearing wave for motivating beam direction vertical；And it controls arrayed ultrasonic probe and emits predetermined ultrasonic signal towards biological tissue and obtain
Take third ultrasound echo signal.
Third computation subunit 16 is used to calculate biological group according to the first ultrasound echo signal and third ultrasound echo signal
Knit the second spread speed of shearing wave of interior multiple observation points；The springform of observation point is calculated according to the second spread speed of shearing wave
Amount.
Further optionally, as shown in Figure 10 D, first acquisition unit 10 further includes synthesizing subunit 17, for that will see
Multiple elasticity modulus corresponding at least two predetermined angulars synthesize an elasticity modulus at measuring point, thus will be with multiple predetermined angles
It spends corresponding multiple elasticity modulus distribution maps and synthesizes an elasticity modulus distribution map.
Embodiment six
The embodiment of the invention provides a kind of electronic equipment, and as shown in figure 11, which may include processor
1101 and memory 1102, wherein processor 1101 can be connected with memory 1102 by bus or other modes, Figure 11
In by by bus connect for.
Processor 1101 can be central processing unit (Central Processing Unit, CPU).Processor 1101 is also
It can be other general processors, digital signal processor (Digital Signal Processor, DSP), dedicated integrated electricity
Road (Application Specific Integrated Circuit, ASIC), field programmable gate array (Field-
Programmable Gate Array, FPGA) either other programmable logic device, discrete gate or transistor logic,
The combination of the chips such as discrete hardware components or above-mentioned all kinds of chips.
Memory 1102 be used as a kind of non-transient computer readable storage medium, can be used for storing non-transient software program,
Non-transient computer executable program and module, as the corresponding program of infiltration tissue testing method in the embodiment of the present invention refers to
Order/module is (for example, first acquisition unit 10, selection unit 20 shown in Figure 10 A, second acquisition unit 30,40 and of judging unit
Determination unit 50).Non-transient software program, instruction and the mould that processor 1101 is stored in memory 1102 by operation
Block, thereby executing the various function application and data processing of processor, i.e. infiltration tissue in realization above method embodiment
Detection method.
Memory 1102 may include storing program area and storage data area, wherein storing program area can store operation system
Application program required for system, at least one function；It storage data area can the data etc. that are created of storage processor 1101.This
Outside, memory 1102 may include high-speed random access memory, can also include non-transient memory, for example, at least a magnetic
Disk storage device, flush memory device or other non-transient solid-state memories.In some embodiments, the optional packet of memory 1102
The memory remotely located relative to processor 1101 is included, these remote memories can pass through network connection to processor
1101.The example of above-mentioned network includes but is not limited to internet, intranet, local area network, mobile radio communication and combinations thereof.
One or more of modules are stored in the memory 1102, when being executed by the processor 1101,
It executes such as the infiltration tissue testing method in Fig. 5 A to Fig. 5 D illustrated embodiment.
Above-mentioned electronic equipment detail can be corresponded to retouches refering to correlation corresponding in embodiment shown in Fig. 5 A to Fig. 5 D
It states and is understood with effect, details are not described herein again.
It is that can lead to it will be understood by those skilled in the art that realizing all or part of the process in above-described embodiment method
Computer program is crossed to instruct relevant hardware and complete, the program can be stored in a computer-readable storage medium
In, the program is when being executed, it may include such as the process of the embodiment of above-mentioned each method.Wherein, the storage medium can for magnetic disk,
CD, read-only memory (Read-Only Memory, ROM), random access memory (Random Access
Memory, RAM), flash memory (Flash Memory), hard disk (Hard Disk Drive, abbreviation: HDD) or solid state hard disk
(Solid-State Drive, SSD) etc.；The storage medium can also include the combination of the memory of mentioned kind.
Embodiment seven
The embodiment of the invention provides a kind of infiltration tissue detection system, which includes that electronics described in example IV is set
It is standby, it further include for generating ultrasonic beam according to instruction and receiving the ultrasonic probe of ultrasonic echo.
Although being described in conjunction with the accompanying the embodiment of the present invention, those skilled in the art can not depart from the present invention
Spirit and scope in the case where various modifications and variations can be made, such modifications and variations are each fallen within by appended claims institute
Within the scope of restriction.
Claims (10)
1. a kind of infiltration tissue testing method characterized by comprising
Obtain the elastic information distribution map of biological tissue；
Multiple observation points are chosen on the elastic information distribution map；
Obtain the difference of two observation point corresponding position elastic informations；
Judge whether the difference is greater than or equal to preset threshold；
When the difference is greater than or equal to the preset threshold, determine between described two observation points there is hard sign ring region.
2. infiltration tissue testing method according to claim 1, which is characterized in that described in the elastic information distribution map
The step of upper selection multiple observation points, comprising:
Multiple observation points are chosen along a plurality of parallel straight line on the elastic information distribution map.
3. infiltration tissue testing method according to claim 1, which is characterized in that the elasticity letter for obtaining biological tissue
The step of ceasing distribution map, comprising: obtain the elasticity modulus that observation point corresponding position is motivated about the first predetermined angular；It is described to obtain
The step of elasticity modulus for taking observation point corresponding position to motivate about the first predetermined angular includes:
Arrayed ultrasonic probe is controlled to emit predetermined ultrasonic signal towards biological tissue and obtain the first ultrasound echo signal；
Control arrayed ultrasonic probe generate with biological tissue surface in the first predetermined angular the first pulse excitation wave beam to
Thrust is generated to biological tissue, biological tissue generates vertical with the first pulse excitation beam direction under the thrust
Shearing wave；And it controls arrayed ultrasonic probe and emits the predetermined ultrasonic signal towards biological tissue and obtain the second ultrasound time
Wave signal；
Multiple observation points pair in biological tissue are calculated according to first ultrasound echo signal and second ultrasound echo signal
Answer the first spread speed of shearing wave at position；
The elasticity that observation point corresponding position is motivated about first predetermined angular is calculated according to the first spread speed of shearing wave
Modulus.
4. infiltration tissue testing method according to claim 3, which is characterized in that selected on the elastic information distribution map
When taking multiple observation points, multiple observation points are chosen in a plurality of rectilinear direction vertical with pulse excitation beam direction.
5. infiltration tissue testing method according to claim 3, which is characterized in that the elasticity letter for obtaining biological tissue
The step of ceasing distribution map, further includes: obtain the elasticity that observation point corresponding position is motivated about at least one second predetermined angular
Modulus；Described the step of obtaining the elasticity modulus that observation point corresponding position is motivated about at least one second predetermined angular, wraps
It includes:
Control arrayed ultrasonic probe generate with biological tissue surface in the second predetermined angular the second pulse excitation wave beam to
Thrust is generated to biological tissue, biological tissue generates vertical with the second pulse excitation beam direction under the thrust
Shearing wave；And it controls arrayed ultrasonic probe and emits the predetermined ultrasonic signal towards biological tissue and obtain third ultrasound time
Wave signal；
Multiple observation points in biological tissue are calculated according to first ultrasound echo signal and the third ultrasound echo signal
The second spread speed of shearing wave；The elasticity modulus of observation point is calculated according to the second spread speed of shearing wave.
6. infiltration tissue testing method according to claim 5, which is characterized in that the elasticity letter for obtaining biological tissue
The step of ceasing distribution map, further includes:
Multiple elasticity modulus corresponding with multiple predetermined angulars at observation point are synthesized into an elasticity modulus, thus will with it is multiple pre-
Determine the corresponding multiple elasticity modulus distribution maps of angle and synthesizes an elasticity modulus distribution map.
7. a kind of infiltration tissue detection device characterized by comprising
First acquisition unit, for obtaining the elastic information distribution map of biological tissue；
Selection unit, for choosing multiple observation points on the elastic information distribution map；
Second acquisition unit, for obtaining the difference of two observation point corresponding position elastic informations；
Judging unit, for judging whether the difference is greater than or equal to preset threshold；
Determination unit, for determining and being deposited between described two observation points when the difference is greater than or equal to the preset threshold
In sign ring region firmly.
8. a kind of electronic equipment characterized by comprising
Memory and processor communicate with each other connection, are stored in the memory between the memory and the processor
Computer instruction, the processor is by executing the computer instruction, thereby executing as claimed in any one of claims 1 to 6
Infiltrate tissue testing method.
9. a kind of computer readable storage medium, which is characterized in that the computer-readable recording medium storage has computer to refer to
It enables, the computer instruction is for making the computer perform claim require 1 to 6 described in any item infiltration tissue detection sides
Method.
10. a kind of infiltration tissue detection system characterized by comprising
Ultrasonic probe, for generating ultrasonic beam according to instruction and receiving ultrasonic echo；
Electronic equipment according to any one of claims 8.
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