CN109868097B - Adhesive for bonding hydrogel material and solid material and bonding method - Google Patents
Adhesive for bonding hydrogel material and solid material and bonding method Download PDFInfo
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Abstract
The invention provides a binder for binding a hydrogel material and a solid material, which is a dispersion liquid formed by dispersing nanoparticles in a solvent; the solvent is a solvent that can swell the hydrogel. The invention adopts the nano particles as the bonding medium of the hydrogel material and the solid material, and can improve the interface stripping toughness by dozens of times. The method has important significance in the aspect of interface basic research, has important significance in the assembly and application of high polymer materials in different scales, and simultaneously has important significance in developing novel special glue and adhesive tape systems which can cope with various environments.
Description
Technical Field
The invention relates to the technical field of nano materials, in particular to a bonding agent for bonding a hydrogel material and a solid material and a bonding method.
Background
The hydrogel cannot be compatible with and bonded with a plurality of adhesives due to unique surface properties, such as abundant moisture, molecular chains in a swelling state and the like, so that an effective and firm bonding surface is formed.
Thus, the bonding of hydrogel materials to solid materials is very difficult.
Disclosure of Invention
In view of the above, the present invention provides a bonding agent and a bonding method for bonding a hydrogel material and a solid material, which can firmly bond the hydrogel material and the solid material.
In order to solve the technical problems, the invention provides a binder for binding hydrogel and a solid material, which is a dispersion liquid formed by dispersing nanoparticles in a solvent;
the solvent is a solvent that can swell the hydrogel, i.e., a benign solvent for the bonded hydrogel material.
The hydrogel material bonded by the present invention is preferably any one or more of a synthetic polymer hydrogel material and a naturally derived polymer hydrogel.
The solid material bonded by the invention is preferably any one or more of plastic material, rubber material, inorganic non-metallic material, metal material, biological tissue and biological material.
Preferably, the hydrogel material is different from the solid material.
Because of their similar properties, in some embodiments of the present invention, hydrogel materials formulated with acrylamide, methacryloxyethyltrimethylammonium chloride, N-methylenebisacrylamide, and agarose are exemplified.
In other embodiments of the present invention, hydrogel materials formulated with N-isopropylacrylamide, methacryloyloxyethyltrimethylammonium chloride, N-methylenebisacrylamide, and agarose are exemplified.
The hydrogel material of the present invention is not limited thereto, and may be a hydrogel material well known to those skilled in the art.
In some embodiments of the invention, the solid material is a substrate of almost all kinds of materials, such as stainless steel, aluminum, titanium, copper, glass, aluminum nitride ceramic, alumina ceramic, quartz, silicon wafer, gallium arsenide wafer, polycarbonate, polyetherimide, polyethylene terephthalate, polyvinyl chloride, polymethyl methacrylate, polytetrafluoroethylene, VHB tape, polyurethane rubber, silicone rubber, skin, liver, kidney, heart, bone, muscle, etc.
The adhesive adopts nano particles, and is dispersed in a solvent to form nano particle dispersion liquid.
The solvent is capable of swelling the hydrogel, and preferably, the solvent is a water-miscible solvent. Further preferably, the solvent is one or more of water, ethanol, methanol, isopropanol, acetone, N-dimethylformamide and dimethyl sulfoxide; more preferably deionized water and/or ethanol.
The particle size of the nano particles is preferably 15-100 nm, and more preferably 30-70 nm; in the dispersion, the concentration of the nanoparticles is preferably 10 wt% to 30 wt%, and more preferably 15 wt% to 25 wt%.
Wherein the nanoparticles are preferably one or more of metal nanoparticles, semiconductor nanoparticles, ceramic nanoparticles, polymer nanoparticles, carbon-based nanoparticles, and liposome nanoparticles.
In the present invention, the metal nanoparticles are preferably one or more of gold nanoparticles, silver nanoparticles, copper nanoparticles, and the like, which are well known to those skilled in the art.
The ceramic nanoparticles are preferably one or more of iron oxide, titanium oxide, calcium oxide, aluminum oxide, zirconium oxide, silicon oxide, zinc oxide, barium sulfate, calcium carbonate, calcium phosphate, calcium silicate nanoparticles, and the like, which are well known to those skilled in the art.
The polymer nanoparticles are preferably synthetic polymer nanoparticles and grafted nanoparticles thereof, such as: polylactic acid, polystyrene, polymethyl dimethacrylate, polycyclocaprolactone and polyacrylic acid; natural polymeric nanoparticles and grafted nanoparticles thereof, such as: chitosan, sodium alginate, hyaluronic acid, and the like, as would be known to one skilled in the art.
The carbon-based nanoparticles are preferably carbon nanoparticles.
Further preferably, the nanoparticles are silica nanoparticles, and the particle size of the silica nanoparticles is preferably 20-80nm, and more preferably 40-60 nm. In some embodiments of the invention, the silica nanoparticles have a particle size of 50 nm.
In certain embodiments of the invention, the nanoparticles are surface chemically modified and/or activated treated nanoparticles.
The specific method of the surface chemical modification and activation treatment is not particularly limited, and the nanoparticle surface has a specific group and can interact with the molecular chain of the hydrogel material.
The specific group is preferably at least one of hydrogen bond-rich group, carboxyl group, amino group, sulfhydryl group, catechol, hydroxyl group, double bond, phosphate radical and carbonyl group.
Preferably, the surface chemical modification is any one or more of silane coupling reaction modification, surface polymer grafting, surface atom transfer radical polymerization modification, polymer wrapping modification and ligand exchange.
In some embodiments of the invention, the silane coupling reaction modification is specifically a modification with a carboxy silane.
In the present invention, the activation treatment is preferably any one or more of acid treatment, alkali treatment, heat treatment, and plasma treatment.
In some embodiments of the invention, the nanoparticles are sequentially activated by alkali treatment and modified by silane coupling.
The present invention disperses the above nanoparticles in a solvent to form a dispersion.
The solvent is capable of swelling the hydrogel.
In some embodiments of the invention, the solvent is water and/or ethanol.
The dispersion method is not particularly limited, and may be a dispersion method of nanoparticles known to those skilled in the art, and the present invention preferably employs any one or more of a high-speed shearing method, a ball milling method, and an ultrasonic crushing method. Further preferred is a ball milling method.
Preferably, the concentration of the nanoparticles in the nanoparticle dispersion is 10 wt% to 30 wt%.
The invention provides a method for bonding a hydrogel material and a solid material, which comprises the following steps:
and (3) bonding the hydrogel material and the solid material by using the binder as a bonding medium.
The hydrogel material is the same as the solid material, and is not described in detail herein.
In some embodiments of the invention, the bonding method is specifically:
and coating the adhesive on the surface of the solid material to be bonded, contacting the surface of the hydrogel material to be bonded with the adhesive, and keeping the contact for more than 60 seconds to bond the hydrogel material and the solid material into a whole.
Preferably, the hydrogel material is taken out from the template and prepared into a preset shape.
In some embodiments of the present invention, the hydrogel material is a synthetic polymer hydrogel, and the template is a polymethylmethacrylate frame.
Preferably, the surface of the hydrogel material to be bonded is contacted with the binder, and the binder is pressed to be fully contacted with the solid material and kept for more than 60 seconds, so that the hydrogel material and the solid material are firmly bonded into a whole.
In some embodiments of the present invention, the pressing pressure is 60 s.
The bonding method provided by the invention has no special requirement on the cleanness of the surface of the solid material, and the surface of the solid material has water stains, oil stains and other stains, so that the bonding effect is not influenced.
The invention provides a novel application of nano effect, which utilizes the interaction between nano particles and the surface of a hydrogel material, utilizes a solvent as a medium for the interaction and utilizes the common physical action between the nano particles and the surface of the material to achieve the effect of bonding the hydrogel material and a solid material by using the nano particles as a bonding agent.
The invention also provides an adhesive tape, comprising:
adhesive plaster made of hydrogel composite matrix material and the adhesive;
the hydrogel is used as an adhesive tape adhesion layer, the adhesive is coated on the surface of a solid material to be bonded, the adhesive tape adhesion layer is contacted with the adhesive and kept for more than 60 seconds, and the adhesive tape and the solid material are bonded into a whole.
Firstly, hydrogel is taken as an adhesive layer of the adhesive tape, and is compounded with a matrix material to prepare the adhesive tape, and the adhesive tape is matched with the adhesive to form the adhesive tape system.
Specifically, the adhesive is coated on the surface of the solid material to be bonded, the adhesive layer of the adhesive tape is contacted with the adhesive and kept for more than 60 seconds, and the adhesive tape and the solid material are bonded into a whole.
In the invention, the substrate material is preferably polypropylene, polyvinyl chloride, polyethylene foam and poly-p-phthalic acid plastic; a cloth-based material; a paper based material; and fiber materials, such as polyester fiber and the like.
The solid material is any one or more of plastic material, rubber material, inorganic non-metal material, biological tissue and biological material.
The invention adopts the nano particles as the bonding medium of the hydrogel material and the solid material, and can improve the interface stripping toughness by dozens of times. The method has important significance in the aspect of interface basic research, has important significance in the assembly and application of high polymer materials in different scales, and simultaneously has important significance in developing novel special glue and adhesive tape systems which can cope with various environments.
Drawings
FIG. 1 is a schematic illustration of the successful bonding of hydrogels on glass using nanoparticles of example 1;
FIG. 2 is a pictorial representation of the successful bonding of hydrogels on glass using nanoparticles of example 1;
FIG. 3 is a scanning electron micrograph of a hydrogel side-peeled surface of example 1 after successfully bonding a hydrogel to glass using nanoparticles;
FIG. 4 is a plot of interfacial toughness versus contact time for example 1 successful hydrogel bonding to a substrate using nanoparticles;
FIG. 5 is a graph comparing the interfacial toughness of the successful hydrogel bonding of the nanoparticles of example 1 to a substrate using a commercial flash gel, chemical covalent bonding process;
FIG. 6 is a graph of example 6 successful hydrogel bonding using nanoparticles on a surface wet glass substrate compared to interfacial toughness measured using 90 degree peel after bonding to a dry substrate;
FIG. 7 is a graph of an actual product of example 7 using nanoparticles to successfully bond a hydrogel to an oil-stained glass substrate and a comparison of interfacial toughness measured using 90 degree peel after bonding to a dry substrate;
FIG. 8 is a graph comparing the interfacial toughness of example 9, using 90 degree peel, for successful hydrogel bonding to substrates of almost all types of materials using nanoparticles, and the physical adhesion without nanoparticles.
Detailed Description
In order to further illustrate the present invention, the following will describe in detail the adhesive and the bonding method for bonding a polymer material and a solid substrate provided by the present invention with reference to the examples.
Example 1
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano-silica particles modified by carboxyl silane;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agarose into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of the nano silicon dioxide particle dispersion liquid and coating the nano silicon dioxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano silicon dioxide particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
testing the adhesive strength of the hydrogel and the glass surface by using a 90-degree stripping device, wherein the testing speed is 1 mm/s;
and (3) detection results: the interfacial toughness was measured to be 1400J/m.
FIG. 1 is a schematic representation of the successful hydrogel bonding operation on glass using nanoparticles of example 1.
FIG. 2 is a pictorial representation of the successful bonding of hydrogels on glass using nanoparticles of example 1.
FIG. 3 is a scanning electron micrograph of a hydrogel side-peeled surface of example 1 after successfully bonding a hydrogel to glass using nanoparticles. It can be seen that the nanoparticles connect the substrate surface and the hydrogel surface.
FIG. 4 is a plot of interfacial toughness versus contact time for example 1, using nanoparticles to successfully bond a hydrogel to a substrate. The contact time refers to the time the hydrogel and substrate remain in contact to achieve adhesion. It can be seen that a good bond can be formed by pressing 60 seconds.
FIG. 5 is a comparison graph of interfacial toughness for the successful hydrogel bonding to a substrate by the nanoparticles of example 1 (see the curve labeled as nanosol).
Comparative example 1
The hydrogel and glass were bonded using the bonding method of example 1, using a commercial cyanoacrylate glue as the bonding medium.
Bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
testing the adhesive strength of the hydrogel and the glass surface by using a 90-degree stripping device, wherein the testing speed is 1 mm/s;
and (3) detection results: the interfacial toughness was measured to be 1400J/m.
FIG. 5 is a graph comparing the interfacial toughness of the hydrogel and glass after bonding in comparative example 1 (see the curve labeled as instantaneous glue).
Comparative example 2
Modifying template glass by using gamma-methacryloxypropyltrimethoxysilane, synthesizing hydrogel in situ, and covalently connecting a glass surface group and a hydrogel polymer network into a whole. The hydrogel was the same as in example 1.
Bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
testing the adhesive strength of the hydrogel and the glass surface by using a 90-degree stripping device, wherein the testing speed is 1 mm/s;
and (3) detection results: the interfacial toughness was measured to be 1400J/m.
FIG. 5 is a graph comparing the interfacial toughness after bonding of hydrogel to glass in comparative example 2 (see the curve labeled covalent attachment).
As can be seen from a comparison of FIG. 5, the performance of the hydrogel and glass bonded by the bonding method described herein is substantially as good as that of an elastomer.
Example 2
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano ferroferric oxide particles modified by carboxyl silane;
taking 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agar, heating to 95 ℃ and keeping for 10 minutes to prepare hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of the nano ferroferric oxide particle dispersion liquid and coating the nano ferroferric oxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano ferroferric oxide particle dispersion liquid, slightly pressing the hydrogel to be in full contact with the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 1400J/m.
Example 3
Preparing 5mL of 20 wt% aqueous dispersion of 50nm gold nanoparticles modified by carboxyl silane;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of the nano gold particle dispersion liquid and coating the nano gold particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano-gold particle dispersion liquid, slightly pressing the hydrogel to make the hydrogel fully contact with the surface of the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 1200 joules per square meter.
Example 4
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano polystyrene particles modified by carboxyl silane;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of nano polystyrene particle dispersion liquid and coating the nano polystyrene particle dispersion liquid on substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano polystyrene particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 1500 joules per square meter.
Example 5
Preparing 50nm nano-silica particles modified by carboxyl silane into 5mL of 20 wt% ethanol dispersion liquid;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.1g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of the nano silicon dioxide particle dispersion liquid and coating the nano silicon dioxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano silicon dioxide particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 1200 joules per square meter.
Example 6
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano-silica particles modified by carboxyl silane;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
spraying deionized water on the substrate glass to be adhered by using a spray can;
sucking 200 microlitres of the nano silicon dioxide particle dispersion liquid and dripping the nano silicon dioxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano silicon dioxide particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 1400 joules per square meter.
While a dried glass substrate was used as a comparison.
In FIG. 6, a is a diagram of example 6 using nanoparticles to bind hydrogels on a surface-wetted glass substrate.
Graph b is a comparison of interfacial toughness measured using nanoparticles, with hydrogel bonded to a surface wet glass substrate, and 90 degree peel on a surface dry glass substrate, respectively.
It can be seen that the wet substrate has no effect on the bonding effect.
Example 7
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano-silica particles modified by carboxyl silane;
preparing 2g of acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.2g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
spraying vegetable oil on the substrate glass to be adhered by using a spraying pot;
sucking 200 microlitres of the nano silicon dioxide particle dispersion liquid and dripping the nano silicon dioxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano silicon dioxide particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
the hydrogel was tested for adhesive strength to the glass surface using a 90 degree peel apparatus at a test speed of 1 mm/s.
And (3) detection results: the interfacial toughness was measured to be 450 joules per square meter.
While a dried glass substrate was used as a comparison.
In fig. 7, a is a picture of example 7, which uses nanoparticles to bind hydrogel on a glass substrate with greasy surface.
And b is a comparison graph of interfacial toughness measured by using nanoparticles to bond hydrogel on a glass substrate with greasy surface and by 90-degree peeling on a glass substrate with dry surface.
It can be seen that the greasy base had no effect on the bonding effect.
Example 8
Preparing 5mL of 20 wt% aqueous dispersion of 50nm nano-silica particles modified by carboxyl silane;
preparing 3.5g of N-isopropyl acrylamide, 3g of methacryloyloxyethyl trimethyl ammonium chloride, 2mg of N, N-methylene bisacrylamide, 117350 mg of photoinitiator, 10mL of water and 0.1g of agar into hydrogel precursor liquid;
injecting the precursor solution into a mold, and crosslinking for 1 hour under 365nm ultraviolet rays to form;
taking out the formed hydrogel from the mold, soaking in deionized water for 3 days, and replacing and cleaning to obtain residual components;
absorbing 200 microliters of the nano silicon dioxide particle dispersion liquid and coating the nano silicon dioxide particle dispersion liquid on the substrate glass to be adhered;
taking out the cleaned hydrogel, covering the hydrogel on the surface of the glass coated with the nano silicon dioxide particle dispersion liquid, slightly pressing the hydrogel to fully contact the glass, and keeping the hydrogel for 60s to complete the bonding of the hydrogel and the surface of the glass;
bonding a 100-micron-thick polycarbonate film on the back of the hydrogel by using cyanoacrylate glue to serve as a hard back for testing;
testing the adhesive strength of the hydrogel and the glass surface by using a 90-degree stripping device, wherein the testing speed is 1 mm/s;
and (3) detection results: the interfacial toughness was measured to be 1400J/m.
Example 9
The method of example 1 was used to replace the substrate material with stainless steel, aluminum, titanium, copper, glass, aluminum nitride ceramic, alumina ceramic, quartz, silicon wafer, gallium arsenide wafer, polycarbonate, polyetherimide, polyethylene terephthalate, polyvinyl chloride, polymethyl methacrylate, polytetrafluoroethylene, VHB tape, urethane rubber, silicone rubber, skin, liver, kidney, heart, bone, and muscle, respectively, and the results of the bonding were examined with hydrogel, and are shown in fig. 8.
The substrate and the hydrogel were bonded by physical adsorption, and the interfacial toughness after bonding was measured for comparison, and the results are shown in fig. 8.
The physical adsorption operation is as follows: directly pasting the hydrogel on a substrate without using nano-particle dispersion liquid, slightly pressing the hydrogel to make the hydrogel fully contact with the substrate, and keeping the hydrogel for 60s to complete the physical adsorption of the hydrogel and the glass surface.
As can be seen from the above examples and comparative examples, the present invention uses nanoparticles as a binder to firmly bond the hydrogel material to the solid substrate.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (7)
1. An adhesive for bonding a hydrogel and a solid material, which is a dispersion liquid formed by dispersing nanoparticles in a solvent;
the particle size of the nano particles is 30-70 nm; in the dispersion liquid, the concentration of the nano particles is 15-25 wt%; the nano-particles are carboxyl silane modified nano-particles;
the solvent is a solvent that can swell the hydrogel.
2. The binder of claim 1, wherein the carboxysilane-modified nanoparticles comprise nanoparticles selected from the group consisting of metal nanoparticles, semiconductor nanoparticles, ceramic nanoparticles, polymer nanoparticles, carbon-based nanoparticles, and liposome nanoparticles.
3. The binder of claim 2, wherein the metal nanoparticles are one or more of gold nanoparticles, silver nanoparticles, and copper nanoparticles; the ceramic nano-particles are one or more of iron oxide, titanium oxide, calcium oxide, aluminum oxide, zirconium oxide, silicon oxide, zinc oxide, barium sulfate, calcium carbonate, calcium phosphate and calcium silicate nano-particles; the polymer nano particles are one or more of polylactic acid, polystyrene, poly (methyl dimethacrylate), polycyclocaprolactone, polyacrylic acid, chitosan, sodium alginate and hyaluronic acid; the carbon-based nanoparticles are carbon nanoparticles.
4. The binder of claim 1 wherein the hydrogel is one or more of a synthetic polymeric hydrogel and a naturally derived polymeric hydrogel; the solid material is any one or more of a plastic material, a rubber material, an inorganic non-metallic material, a metal material, a biological tissue and a biological material; the solvent is one or more of water, ethanol, methanol, isopropanol, acetone, N-dimethylformamide and dimethyl sulfoxide.
5. A method of bonding a hydrogel material to a solid material, comprising the steps of:
the adhesive of any one of claims 1 to 4 is used as an adhesive medium to bond the hydrogel and the solid material.
6. The method according to claim 5, characterized in that it is in particular:
the adhesive according to any one of claims 1 to 4 is coated on the surface of a solid material to be bonded, the surface of the hydrogel material to be bonded is contacted with the adhesive and kept for more than 60 seconds, and the hydrogel material and the solid material are bonded into a whole.
7. An adhesive tape, comprising:
an adhesive plaster made of a hydrogel composite matrix material, and the adhesive according to any one of claims 1 to 4;
the hydrogel is used as an adhesive tape adhesion layer, the adhesive is coated on the surface of a solid material to be bonded, the adhesive tape adhesion layer is contacted with the adhesive and kept for more than 60 seconds, and the adhesive tape and the solid material are bonded into a whole.
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| CN114149752B (en) * | 2020-09-07 | 2023-03-28 | 中国科学院理化技术研究所 | Adhesive and application thereof |
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| CN103275668A (en) * | 2013-05-09 | 2013-09-04 | 北京大学 | Application of multi-component super-molecule hydrogel as adhesion agent |
| CN105722784A (en) * | 2013-09-10 | 2016-06-29 | 巴黎高等物理化工学院 | Nanoparticles for use in bioadhesion |
| CN105979976A (en) * | 2013-12-10 | 2016-09-28 | 法国国家健康医学研究院 | Methods for adhering tissue surfaces and materials and biomedical uses thereof |
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