CN109864373A - A kind of safety dipped gloves and its production method - Google Patents
A kind of safety dipped gloves and its production method Download PDFInfo
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- CN109864373A CN109864373A CN201910072929.8A CN201910072929A CN109864373A CN 109864373 A CN109864373 A CN 109864373A CN 201910072929 A CN201910072929 A CN 201910072929A CN 109864373 A CN109864373 A CN 109864373A
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Abstract
The invention discloses a kind of production methods of safety dipped gloves, include the following steps: S1, prepare glove mould；S2, leaching coagulator；S3, purifying natural rubber latex: aluminum hydroxide solution and latex stabilizer are added in natural rubber latex, is sufficiently mixed and stirs, centrifugal concentrating is carried out after stirring；S4, it prepares low protein natural rubber latex: deionized water being added in the purifying natural rubber latex obtained in step s3, then protein denaturation agent solution and polar solvent are added in natural rubber latex, obtains low protein natural rubber latex；S5, leaching low protein natural rubber latex；S6, ultrasonic cleaning；S7, vulcanization；S9, drying, inspection, packaging.The present invention can purify natural rubber latex, carry out deproteinization processing to natural rubber latex after purification, and obtained latex content of milk protein is low, the allergic reaction that can effectively avoid hand autopath, production method are simple, high production efficiency.
Description
Technical field
The present invention relates to gloves technical field more particularly to a kind of safety dipped gloves and its production methods.
Background technique
The medical product of natural rubber latex preparation has become the widely used medical product of countries in the world institute, consumption
Maximum is safety dipped gloves, accounts for 70% or more.Safety dipped gloves have elasticity is good, wearing comfort, tensile strength are relatively strong,
Not cracky, chemical defence superior performance, suitable for stringent dustfree environment the advantages that.
Natural rubber contains about 6% nonrubber ingredient, including protein, lipid etc., will lead to the pair in modifying process
Latex allergy problem in reaction and product use.Removal of protein can carry out in the latex stage, because it is known that nonrubber ingredient
It is present in rubber particles surface with form of single sheet.For example, a small amount of protein can be from natural rubber after natural rubber latex curdling
Removing.In the latex stage, is chemically and physically interacted by denaturant to control, rubber particles surface can be efficiently separated
Protein.
Interaction forms intact proteins plasma membrane and phospholipid monolayer between rubber particles surface protein and lipid, because of albumen
The hydrophobic side chain of matter can interact with the hydrophobic tail end of lipid, and proteinaceous solid is scheduled on rubber surface.It studies previous
In, with the peptide chain of proteolytic enzyme decomposing protein, change protein structure with urea come deproteination matter, that is to say, that only
Protein denaturation, and lipid does not have.Since the protein and lipid on rubber particles surface interact, the removing of lipid
It is also highly important.By the lipid for removing surface, it is also possible to effectively deproteination matter.
All proteins in natural rubber latex are removed, denaturant and polar organic solvent are added to natural rubber latex
In prepare no protein natural rubber.Urea be used in combination with acetone (good solvent of lipid) can provide protein and lipid it
Between free space, help protein isolate matter.Gained nitrogen content is 0.00%, it is meant that without protein attachment in natural rubber
The surface of particle.
Natural emulsion is the lotion obtained from natural rubber tree.Protein contained in natural emulsion gloves is mainly jail
Gu combining the protein in the protein and whey pressure in micelle, remaining water-solubility protein is exactly anaphylactogen.Meanwhile in conjunction with
Macromolecule protein on micelle surface, which can also degrade, regenerates water-solubility protein, and during producing gloves, protein can be to
Glove interior surface migrates, and most soluble proteins in finished product gloves are distributed in glove interior surface, these soluble eggs
At least 4 kinds of soluble polypeptides, can cause the allergic reaction of human body in white matter.
At the same time, during use, some problems present in natural latex products also gradually expose out.
Investigation display, 17% nursing staff and 8% patient contact latex can occur allergic reaction and natural latex products contact
Autopath will appear the allergic reactions such as bronchial asthma, contact urticaria, eye conjunctivitis and rhinitis, can cause when serious
Quick property shock, so it is dead.Different ethnic groups are different to the degree of allergic reaction of natural latex products, especially white people, to natural
The allergic reaction of latex product is even more serious.
The illness rate in relation to latex allergy and disease incidence do not have exact epidemiologic data at present, mainly due to not having
The diagnostic criteria disunity of satisfied diagnostic method and various countries, on the whole, the latex sensitization rate of general population are very low,
Less than the illness rate of latex allergy in investigation 7 years old children of Britain such as 1%, Roberts, discovery latex in normal children crowd
Sensitization rate is very low, and only 0.2%.And for people at highest risk, for example rubber industry worker, medical personnel, received repeatedly
The patient of operation, especially children's spina bifida and Malformations of The Urinary System infant, latex sensitization rate are significantly raised.In spina bifida patient
In, latex allergy reaches 28%-67%, and according to Konz etc., 28 (72%) have latex allergy history in 36 spina bifida patients, and
Spinal injury, cerebrovascular accident and normal person organize equal latex-free allergies.
Therefore, how to be directed to disadvantage present in the above-mentioned prior art and carry out research and development improvement, actually exerted needed for relevant industry
Power research and development target, the application designer in view of this, be think and creation idea, designed then with the experience of many years, pass through
In many ways sampling test is inquired into and is studied, and repeatedly amendment improvement, be releasing the application.
Such as application No. is 200410050452.7 Chinese invention patents to disclose a kind of low-protein rubber Medical hand
The production technology of set, gloves are essentially identical with the prior art before demoulding, and deproteinization processing is increased after demoulding.Processing method
It is to make de- Protein Extraction solution with borax, ammonium hydroxide and water, gloves is stirred 2 hours at a temperature of 60-65 DEG C, are down to soak at room temperature
It 22 hours, changes clear water and washs 20-30 minutes, boiling vulcanizes breading agent, and water dumping sky is dry and cold but.But at the production technology deproteinization
Reason method is complex, and more protein is remained in latex.
For another example application No. is 201510419988.X Chinese invention patent disclose a kind of system of deproteinized natural rubber
Preparation Method includes the following steps: that polar solvent 1) is added in fresh natural rubber latex or concentrated natural rubber latex stablizes；
2) deionized water is added to dilute rubber latex, centrifuge separation removal impurity collects upper rubber phase；3) on step 2) gained
Layer rubber phase is diluted with deionized water, is stirring and complex enzyme formulation is added under weak basic condition, making under certain reaction condition
Protein degradation in rubber latex；4) impurity after removal protein degradation is centrifugated by centrifuge, by degrading repeatedly
Make protein removal contained by latex, obtains deproteinized natural rubber.But the method for removing protein of the natural rubber is complex, it is raw
Produce low efficiency.
To sum up, it is necessary to design that the protein content in a kind of latex is low, effectively avoids allergic reaction, the life of autopath
Production method is simple, at low cost, high production efficiency, dresses light, flexible, the safety dipped gloves of good permeability and health environment-friendly
And its production method.
Summary of the invention
That in view of the deficiencies of the prior art, it is an object of the present invention to provide the protein contents in a kind of latex is low, effectively keeps away
Allergic reaction, the production method for exempting from autopath be simple, at low cost, high production efficiency, wearing are light, flexible, and good permeability is simultaneously
And the safety dipped gloves and its production method of health environment-friendly.
In order to solve the above-mentioned technical problem, the invention discloses a kind of production method of safety dipped gloves, including it is as follows
Step:
S1, prepare glove mould: compatible glove mould selected according to gloves specification to be produced, to glove mould into
Row is cleaned and is dried；
S2, leaching coagulator: glove mould is immersed in coagulator, and is dried to the glove mould after leaching coagulator；
S3, purifying natural rubber latex: aluminum hydroxide solution and latex stabilizer are added in natural rubber latex, sufficiently
It is mixed and stirred for, centrifugal concentrating is carried out after stirring, obtain purifying natural rubber latex；
S4, prepare low protein natural rubber latex: in the purifying natural rubber latex obtained in step s3 be added go from
Sub- water is diluted, then protein denaturation agent solution and polar solvent are added in the natural rubber latex after dilution, is obtained
Low protein natural rubber latex；
S5, leaching low protein natural rubber latex: glove mould is immersed in low protein natural rubber latex, latex temperature is
40-55 DEG C, dip time 1-3min, after glove mould impregnation is newborn, dry 3-5min under the conditions of 100-125 DEG C；
S6, ultrasonic cleaning: the gloves for having soaked low protein natural rubber latex are immersed in rinse bath and carry out ultrasonic cleaning；
S7, vulcanization: vulcanizing 1-2h in baking oven, and curing temperature is 90-115 DEG C；
S8, washing；
S9, drying, inspection, aseptic packaging are simultaneously put in storage.
Further, the coagulator in step S2 is the mixture of calcium chloride, calcium nitrate and water, chlorination in the mixture
The mass percent of calcium, calcium nitrate and water is respectively 10wt%, 10wt% and 80wt%.
Further, the quality of the aluminum hydroxide solution in the step S3 and natural rubber latex is 1-3 than range:
Latex stabilizer in 50, the step S3 is sodium hydroxide solution.
Further, the protein denaturant is urea, guanidine hydrochloride, lauryl sodium sulfate, one in mercaptoethanol
Kind is a variety of, and the polar solvent is the one or more of ethyl alcohol, acetone or propylene glycol.
Further, the mass percent range of the protein denaturant Proteins In Aqueous Solutions denaturant is 0.05-
1.5wt%.
It preferably, further include the impurity being centrifuged by centrifugal device in removal latex after protein degradation in the step S4
Centrifugation step.
It further, further include that its protein is sampled and detected to the low protein natural rubber latex prepared in step S4
The step of content, repeats step S3 and S4 when the protein content in latex is higher than 50 μ g/g.
Further, the supersonic frequency of ultrasonic cleaning is 15-30KHz in step S4.
Further, the rinse bath includes the first rinse bath, the second rinse bath and third rinse bath, gloves ultrasonic cleaning
It is cleaned in the first rinse bath, the second rinse bath and third rinse bath respectively afterwards, first rinse bath, the second rinse bath
Cleaning temperature range with third rinse bath is respectively 45-55 DEG C, 45-60 DEG C and 40-60 DEG C.
Correspondingly, the invention also discloses a kind of safety dipped gloves, and the safety dipped gloves are using described above
The production method of safety dipped gloves is made.
The invention has the following beneficial effects:
(1) production method of safety dipped gloves of the invention can purify natural rubber latex, to after purification
Natural rubber latex carry out deproteinization processing, obtained latex content of milk protein is low, can effectively avoid gloves from using
The allergic reaction of autopath, production method be simple in the process, at low cost, high production efficiency.
(2) production method of safety dipped gloves of the invention removes day using protein denaturant and polar solvent
Protein in right rubber latex, can be effectively reduced the protein content in latex, and can height deproteinization, obtain
The latex of low protein content.
(3) production method of safety dipped gloves of the invention passes through the albumen in the natural rubber after removal of protein
Matter content significantly reduces, and reduces the water imbibition of gloves obtained, substantially increases the insulating properties of gloves, be not in protein
Allergic problem, while because its tensile strength becomes larger, avoid low stress relaxation, glove product more endurance.
(4) production method of safety dipped gloves of the invention, is washed after curing, remaining protein on gloves
Become more soluble easily in water and protein is moved to the surface of emgloves during heating, can be easier effectively to remove
Albumen reaches further antianaphylactic effect, while also improving other physical properties of gloves.
(5) production method of safety dipped gloves of the invention, because protein becomes more soluble easily in water and heated
Protein is moved to the surface of emgloves in journey, and washing can be easier effectively to remove the egg on emgloves surface after vulcanization
White matter, gloves obtained are highly-safe.
Detailed description of the invention
It, below will be to required in embodiment or description of the prior art in order to illustrate more clearly of technical solution of the present invention
The attached drawing used is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, right
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings
Its attached drawing.
Fig. 1 is the production method flow chart of safety dipped gloves of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, carries out to the technical solution in inventive embodiments clear, complete
Ground description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on this
The embodiment of invention, those of ordinary skill in the art's every other reality obtained without making creative work
Example is applied, shall fall within the protection scope of the present invention.
For the effect for verifying gloves made from the production method of safety dipped gloves of the present invention, applicant has carried out reality respectively
Verifying, experiment content are as follows:
(1) protein denaturant type and polar solvent type；
(2) it is centrifuged；
(3) ultrasonic cleaning and ultrasonic cleaning frequency；
(4) temperature of rinse bath.
Embodiment 1
Please refer to Fig. 1.As shown in Figure 1, present embodiment discloses a kind of production method of safety dipped gloves, including it is as follows
Step: S1, prepare glove mould: compatible glove mould being selected according to gloves specification to be produced, glove mould is carried out
It cleans and dries；
S2, leaching coagulator: glove mould is immersed in coagulator, and the coagulator is the mixed of calcium chloride, calcium nitrate and water
Object is closed, the mass percent of the calcium chloride, calcium nitrate and water is respectively 10wt%, 10wt% and 80wt%, and is solidified to leaching
Glove mould after agent is dried；
S3, purifying natural rubber latex: aluminum hydroxide solution and latex stabilizer are added in natural rubber latex, sufficiently
It is mixed and stirred for, centrifugal concentrating is carried out after stirring, obtain purifying natural rubber latex, wherein aluminum hydroxide solution and natural rubber
The mass ratio of glue latex is 2:50, and the latex stabilizer is sodium hydroxide solution,
S4, prepare low protein natural rubber latex: in the purifying natural rubber latex obtained in step s3 be added go from
Sub- water is diluted, then protein denaturation agent solution and polar solvent are added in the natural rubber latex after dilution, is obtained
Low protein natural rubber latex, wherein the protein denaturant is urea, and the polar solvent is acetone, by urea and third
Ketone difference is soluble in water, forms protein denaturation agent solution and polar solvent solution, albumen in the protein denaturation agent solution
The mass percent of matter denaturant is 1wt%；
It further, further include by miscellaneous after protein degradation in centrifugal device centrifugation removal latex in the step S4
The centrifugation step of matter.
It further, further include that its albumen is sampled and detected to the low protein natural rubber latex prepared in step S4
The step of matter content, repeats step S3 and S4 when the protein content in latex is higher than 50 μ g/g.
S5, leaching low protein natural rubber latex: glove mould is immersed in low protein natural rubber latex, latex temperature is
50 DEG C, dip time 2min, after glove mould impregnation is newborn, dry 3min under the conditions of 110 DEG C；
S6, ultrasonic cleaning: the gloves for having soaked low protein natural rubber latex are immersed in rinse bath and carry out ultrasonic cleaning；
Specifically, the rinse bath includes the first rinse bath, the second rinse bath and third rinse bath, after gloves ultrasonic cleaning
Cleaned in the first rinse bath, the second rinse bath and third rinse bath respectively, first rinse bath, the second rinse bath and
The cleaning temperature of third rinse bath is respectively 45 DEG C, 55 DEG C and 45 DEG C.
Specifically, the supersonic frequency of ultrasonic cleaning is 22KHz in step S4.
S7, vulcanization: vulcanizing 2h in baking oven, and curing temperature is 105 DEG C；
S8, washing；
S9, drying, inspection, aseptic packaging are simultaneously put in storage.
Likewise, embodiment 2-24 is all made of the production method of embodiment 1, the experiment condition of embodiment 1-24 is shown in Table 1.
The experiment condition of 1 embodiment 1-24 of table
Comparative example 1
A kind of production method of rubber gloves, includes the following steps:
S1, prepare glove mould；
S2, leaching coagulator；
S3, leaching rubber latex；
S4, cleaning；
S5, demoulding；
S6, vulcanization；
S7, drying.
Likewise, comparative example 2-6 is all made of the production method of comparative example 1, the experiment condition of comparative example 2-6 is shown in Table 2.
The experiment condition of 2 comparative example 1-6 of table
The standard that gloves performance test is related to has:
" GBT12624-2009 hand protection general technical specifications and test method ", " GB24541-2009 hand protection machine
Tool hazard protective gloves standard ", " the disposable medical grade rubber latex examination gloves of GB10213-2006 ", HG/T3645-1999
The protection of " water extracted protein measuring method Lowry method in natural rubber gloves ", industrial gloves is European standard " EN388 " and general
Standard " EN420 ".It in this application, is the implementation result for verifying the present invention, the test method selection of gloves performance is with reference to above-mentioned
Test method in standard.
One, test method
(1) appearance inspection method
Product appearance is checked using visual method.
3 visual examination defective item of table
(2) specification measurement method
It is deep using ruler measurement gloves overall length, middle finger.Slap the measurement enclosed: at the upward 20mm of the crotch of thumb and index finger
Girth.
(3) flexibility test method
The complete gloves (such as beating or extruding etc.) without by any sofening treatment are extracted, preparing a diameter is
The smooth stainless steel prod of 6.5mm, long 40mm.Prod is placed on a flat surface, tester wears gloves, with food
Refer to and thumbscrew picks up prod, tester continuously picks up prod in 30s should be not less than 3 times.
(4) waterproof test method
When gloves carry out impermeable water test, sample size size and the quantity for allowing unqualified (leakage) gloves answer table 4
In inspection AQL and quality of reception limit (AQL) value limit.
4 inspection AQL of table and quality of reception limit (AQL)
| Performance | Inspection AQL | AQL |
| Physical size (length, width, thickness) | S-2 | 4.0 |
| Impermeability | G-I | 2.5 |
| Breaking tenacity and elongation at break (before aging, after aging) | S-2 | 4.0 |
(5) tensile property test method: breaking tenacity after breaking tenacity and elongation at break, aging before aging and pulling apart is stretched
Long rate
Tensile property is measured according to ISO 37, and 3 test pieces are cut from each gloves, and test result takes intermediate value, examination
Piece should be cut from the palmar hand of gloves or the back of the hand portion.
Breaking tenacity and elongation at break before aging: when being measured by test method as defined in ISO 37, with 2 row dumbbells
Shape test piece, breaking tenacity, elongation at break should meet the regulation of table 5, and inspection AQL and quality of reception limit (AQL) value should meet table 4
Regulation.
5 tensile property of table
Breaking tenacity and elongation at break after aging: thermal aging test should be carried out by method as defined in ISO 188, from gloves
The test piece cut passes through 70 DEG C ± 2 DEG C, after 168h ± 2h aging, and breaking tenacity and elongation at break should meet the requirement of table 5, inspection
The regulation of table 4 should be met by looking into horizontal and quality of reception limit (AQL) value.
(6) hot air aging test method
By sample after (100 DEG C ± 1 DEG C) × (± 0.25h for 24 hours) hot-air accelerated aging test, by the rule of GB24541
Surely carry out the aging of product after rub resistance measurement.
(7) acid resistance test method
Sample of gloves is extracted according to test request, at room temperature, glove coating, which is partially immersed in mass fraction, is
In 40% sulfuric acid solution, the time is for 24 hours, to take out, rinsed well, dried with clear water, carries out rub resistance by the regulation of GB24541
The measurement of property.
(8) alkali resistance test method
Sample of gloves is extracted according to test request, at room temperature, glove coating, which is partially immersed in mass fraction, is
In 35% Strong oxdiative sodium solution, the time is for 24 hours, to take out, rinsed well, dried with clear water, is carried out by the regulation of GB24541 resistance to
The measurement of frictional property.
(9) oil resistivity test method
Sample of gloves is extracted according to test request, and glove coating is partially immersed in No. 0 machinery of standard at room temperature
In oil, the time is for 24 hours, after taking-up, to be rinsed, dried with clear water, and the measurement of rub resistance is carried out by the regulation of GB24541.
(10) basic security performance test methods
The measurement of basic security performance is executed by the regulation of GB18401.
(11) remaining protein content test method in latex
Currently, Lowry method (Lao Lifa) when water-soluble protein content measuring method.
ISO/DIS12243 " the water-soluble protein content in natural rubber and its product that International Organization for standardization formulates
Measuring method ", European standard EN455-3:2000 " requirement and detection of disposable medical gloves-biological property " and
The ASTM D 5712-1999 that American Society for Testing Materials is formulated " analyze in natural rubber and its product by water-soluble protein content
Standard determination method " in be all made of Lao Lifa.
People's Republic of China's chemical industry standard HG/T3645-1999 " natural rubber is also issued in 1999 in China
Water extracted protein measuring method Lowry method in gloves ".Instrument and equipment needed for Lao Lifa is simple, and reagent purchase is easy, test knot
Fruit is reliable, but its treatment process is relative complex.Lowry method is that water soluble protein is extracted from buffer solution, is then sunk
It forms sediment and purifies, protein is separated from the water-soluble substances for may interfere with precipitating, be redissolved the protein for purifying out, compared
Color measures protein content.
Lowry method measuring method principle: with water soluble protein in buffer extractions Heveatex film, then to being dissolved in
Water soluble protein in buffer solution is precipitated and is separated.Protein precipitation with concentration be 0.2mol/L sodium hydroxide it is molten
Liquid re-dissolves, it is made to generate protein-copper complex with copper ion under alkaline condition, this compound can restore Folin reagent
In phosphomolybdic acid-phosphotungstate reagents, generate blue material.The absorbance of solution and the concentration of Proteins In Aqueous Solutions are linearly closed
System, thus can measure the content of water soluble protein in sample.Detailed process is shown in People's Republic of China (PRC) chemical industry standard HG/
T3645-1999 " water extracted protein measuring method Lowry method in natural rubber gloves ".
(12) gloves allergic reaction rate test method
For the allergic reaction rate of gloves made from Statistics Implementation example 1-24 and comparative example 1-6, using following calculation method:
1000 people of certain hospital medical staff is selected to dress the gloves of embodiment 1-24 and comparative example 1-6 production, wearing mode is disposable
Continuous wearing, continuous wear time are 3h, then observe the allergic conditions of medical staff in wearing gloves 12-48 hours.
In addition, there is the people of latex allergy history not in the range of this test, for the personnel for the symptom for having latex allergy, build
View consulting specialist, and carry out prevention work below:
(1) emgloves and other products containing latex are avoided contact with；
(2) it avoids sucking latex dust caused by other labourers or colleague's wearing gloves；
(3) tell that you have latex allergy history to health medical treatment personnel.
Two, test result
The test result of table 6 embodiment 1-24 and comparative example 1-6 gloves
The test result of table 7 embodiment 1-24 and comparative example 1-6 gloves
Remaining protein content and allergic reaction situation in 8 latex of table
(1) appearance test result analysis
As shown in Table 6, in the gloves carry out table 3 produced by the production method of comparative example 1-6 and embodiment 1-24
The gloves of defective item inspection, comparative example 1-6 and embodiment 1-24 without open defect, meet gloves visual examination project
It is required that.
(2) specification measurement result is analyzed
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 are up to specification
With size requirement.
(3) flexibility test result analysis
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 meet flexibly
The requirement of property.
(4) impermeability test result analysis
As shown in Table 7, the performance of watertightness for the gloves produced by the production method of comparative example 1-6 is general, implements
The performance of watertightness for the gloves that the production method of example 1-24 is produced is good.
(5) extension test interpretation of result
As shown in Table 7, breaking tenacity before the aging for the gloves that the production method of comparative example 1-6 is produced and elongation is pulled apart
Breaking tenacity and elongation at break after rate, aging are below in " the disposable medical grade rubber latex examination gloves of GB10213-2006 "
Standard, after the breaking tenacity and elongation at break, aging before the aging for the gloves that the production method of embodiment 1-24 is produced
Breaking tenacity and elongation at break be significantly larger than " the disposable medical grade rubber latex examination gloves of GB10213-2006 " in standard.
It can be seen that the tensile property of gloves made from embodiment 1-24 production method is made much higher than comparative example 1-6 production method
Gloves tensile property.This is because albumen of the purifying natural rubber latex of the application after taking off albumen processing in latex contains
Amount is very low, although the tensile stress of low protein natural rubber is similar compared with General Purpose Rubber, due to the glue of low protein latex
Intergranular distance is smaller, interaction is stronger, and the tensile strength of low protein natural rubber is caused to greatly increase with breaking strength, passes through
The protein content crossed in the natural rubber latex that protein detaches significantly reduces, to reduce the water suction of gloves obtained
Property, the insulating properties of gloves is greatly improved, simultaneously as tensile strength becomes larger, avoids low stress relaxation, makes gloves more
Endurance.
(6) hot air aging test result analysis
As shown in Table 7, the hot-air for the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 is old
Change performance is different, and the thermal aging property for the gloves that the production method of comparative example 1-6 is produced is 2 grades or 3 grades, and
The thermal aging property for the gloves that the production method of embodiment 1-24 is produced reaches 1 grade.
(7) acid resistance test result analysis
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 are qualified, symbol
Close acid resistance requirement.
(8) alkali resistance test result analysis
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 are qualified, symbol
Close alkali resistance requirement.
(9) oil resistivity test result analysis
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 are qualified, symbol
Close oil resistivity requirement.
(10) security performance test result analysis
As shown in Table 6, the gloves produced by the production method of comparative example 1-6 and embodiment 1-24 are qualified, symbol
Close security performance requirement.
(11) remaining protein content test result analysis in latex
As shown in Table 8, remaining protein content is below 50 μ g/g (wherein, μ in embodiment 1-24 natural rubber latex
G/g is the protein content in natural rubber latex), every rubber medical glove protein content is required far below U.S. FDA
No more than the regulation of 1200 μ g, illustrate can by selecting different protein denaturant and polar solvent, using centrifugation, ultrasound
Wave cleans and changes the frequency of ultrasonic cleaning, the multiple rinse baths of setting and changes the temperature of cleaning and can reduce natural rubber latex
In protein content.
(12) gloves allergy rate is analyzed
As in table 8 it is found that gloves made from the production method of comparative example 1-6 and embodiment 1-24 Clinical allergy react try
There is caused allergic reaction type in testing: local nettle rash, urticaria, rhinitis, asthma, fash and conjunctivitis, comparative example
The allergic reaction rate of 1-6 is higher than the allergic reaction rate of embodiment 1-24, and the anaphylactoid degree of comparative example 1-6, which is higher than, to be implemented
The anaphylactoid degree of example 1-24, gloves made from embodiment 1-24 production method it is anaphylactoid highly-safe in right
Gloves made from ratio 1-6 production method.
1. purifying natural rubber latex: the optimum condition of deproteination matter is from natural rubber latex: fresh latex, this
The protein for showing to be attached to natural rubber latex particle surface is physical action, rather than what chemical action was formed.Nonrubber
The nanomatrix of ingredient disappears after deproteination matter, nitrogen content 0.00%.Compared with untreated natural rubber, no albumen day
The green strength of right rubber slightly reduces, and shows that deproteination matter not only significantly affects protein key at optimum conditions, also shadow
Ring phosphatide key.Therefore the presence of initial phosphatide plays an important role in natural rubber, affects the excellent properties of natural rubber.
Adsorption precipitation method deproteination matter technique can effectively remove water soluble protein, reduce rubber latex and be in moist ring
Mouldy generation in border；The removal that certain non-rubber substances such as corpora flava, metal ion etc. can be taken into account simultaneously, it is shallower to obtain color
Rubber.This method, which is utmostly remained, protects beneficial albumen to rubber, may advantageously facilitate vulcanization, improves rubber mechanical property
Can, it delay ageing of rubber.Aluminium hydroxide is a kind of soda acid both sexes hydrogen-oxygen substance, and energy strong adsorption protein, protease etc. are formed
Precipitating, is widely used in the extraction and purification of protein in food industry water.Utilize the height of the positive colloidal sol central particles of aluminium hydroxide
Degree is dispersed and its further be dehydrated can become extremely small activated alumina particle, and surface with higher can live with chemistry
Property, it is easy to protein and generates new aluminium oxide synthetic.
1. using protein denaturant: protein denaturant uses urea, and the peptide chain in natural protein molecules is with certain
Mode coil complications, form specific conformation.The maintenance of this conformation depends on the hydrogen bond in protein molecule.Urine
Element can destroy hydrogen bond, lead to protein molecular structure relaxation, make protein denaturation.The peptide group of the structure of urea and protein is quite
To be similar, it can not only make proton donor when forming hydrogen bond with protein, but also proton acceptor can be made, it and protein form hydrogen bond energy
Power is stronger than water, can destroy hydrogen bond inside protein molecule and cause protein denaturation.
2. polar solvent: for example polar solvent uses ethyl alcohol or acetone, and ethyl alcohol is present in day together with protein denaturant
In right rubber latex, polar solvent plays synergistic effect, can steadily make the protein denaturation in latex；And with urea, third
Ketone, lauryl sodium sulfate completely remove the protein in natural rubber latex.This may be due to acetone be grease and
The good solvent of fatty acid.Grease and fatty acid may fall off from micelle, form micelle in water-soluble liquid phase, may make in micelle
Generate free space.After with urea and lauryl sodium sulfate denaturation, free space may be such that protein is easier from day
Be detached from right rubber, this is because after hydrogen bond fracture protein volume contraction.The protein released is by urea and ten
Sodium dialkyl sulfate is stablized in water phase, this is because the hydrophobic part of protein is covered by urea and lauryl sodium sulfate.
Therefore, colloform is loose after removing grease and fatty acid, and protein meeting nature falls off.Gained purifying natural rubber is no albumen
Matter rubber.
The combination of protein denaturant and polar solvent, generated effect and effect produce unexpected technology effect
The technical effect of the combined deproteination matter of fruit, protein denaturant and polar solvent can be seen by allergic reaction experiment
Out, as can be seen that made from the production method of the application from allergic reaction type, allergic reaction rate and allergic reaction degree
Gloves especially have substantive distinguishing features outstanding and significant progress in the allergic reaction that medical square faces medical staff, more
Promote application of the natural rubber gloves in terms of medical care.
3. multiple centrifugal process: multiple centrifugal process be distributed according to the exhausted most regions of nonrubber materials of latex whey phase and
In small micelle, every centrifugal concentrating latex is primary, and a certain amount of nonrubber materials and little particle are just removed from whey, repeatedly plus water
Diluted latex and centrifugal concentrating can be made into the extremely low latex of nonrubber materials content.Due to sub-fraction in natural rubber latex
Protein is distributed in rubber particles surface, remaining major part is dissolved in whey, and remaining part is connect with latex bottom, because of it
Layering can be come out the Separation of Proteins in aqueous solution using centrifugal process.Natural rubber latex is diluted with water, it is static laggard
Row centrifugation, can remove the most protein in latex, can be repeatedly centrifuged to natural rubber latex, increase centrifugation
Number can obtain the natural rubber latex of low percentages of protein.
4. ultrasonic cleaning: ultrasonic technology is used in the cleaning process of latex and carries out the optimization of operating temperature, benefit
The principle protein isolate matter saltoutd with protein, ultrasonic wave can accelerate speed of saltouing, because the mechanism of ultrasonic wave can promote
Salting-out agents capture the hydrone on protein hydrated sheath, expose so that protein be made to lose hydrated sheath, protein cohesion analysis
Out.
5. the number and temperature of rinse bath: multiple rinse baths are arranged, the water temperature in rinse bath is higher than 40 DEG C, and water temperature is higher than 40
It DEG C can speed up and protein, hydrophilic substance, the calcareous material etc. in natural rubber latex be precipitated from water.It is more preferable in order to reach
Effect, the time of cleaning can be lengthened, ejected wash water keeps clean.
6. being washed after vulcanization: after vulcanization, because protein becomes more soluble easily in water and protein movement during heating
To the surface of emgloves, washing can be easier effectively to remove the protein on emgloves surface after vulcanization.Determine cleaning
The washing water temperature of the quantity of slot and each rinse bath, because the variation of required temperature depends on whole mixing, dipping and vulcanization
Parameter.
The invention has the following beneficial effects:
(1) production method of safety dipped gloves of the invention can purify natural rubber latex, to after purification
Natural rubber latex carry out deproteinization processing, obtained latex content of milk protein is low, can effectively avoid gloves from using
The allergic reaction of autopath, production method be simple in the process, at low cost, high production efficiency.
(2) production method of safety dipped gloves of the invention removes day using protein denaturant and polar solvent
Protein in right rubber latex, can be effectively reduced the protein content in latex, and can height deproteinization, obtain
The latex of low protein content.
(3) production method of safety dipped gloves of the invention passes through the albumen in the natural rubber after removal of protein
Matter content significantly reduces, and reduces the water imbibition of gloves obtained, substantially increases the insulating properties of gloves, be not in protein
Allergic problem, while because its tensile strength becomes larger, avoid low stress relaxation, glove product more endurance.
(4) production method of safety dipped gloves of the invention, is washed after curing, remaining protein on gloves
Become more soluble easily in water and protein is moved to the surface of emgloves during heating, can be easier effectively to remove
Albumen reaches further antianaphylactic effect, while also improving other physical properties of gloves.
(5) production method of safety dipped gloves of the invention, because protein becomes more soluble easily in water and heated
Protein is moved to the surface of emgloves in journey, and washing can be easier effectively to remove the egg on emgloves surface after vulcanization
White matter, gloves obtained are highly-safe.
Above disclosed be only several preferred embodiments of the invention, cannot limit the present invention's certainly with this
Interest field, therefore equivalent changes made in accordance with the claims of the present invention, are still within the scope of the present invention.
Claims (10)
1. a kind of production method of safety dipped gloves, which comprises the steps of:
S1, prepare glove mould: compatible glove mould is selected according to gloves specification to be produced, glove mould is carried out clear
It washes and dries；
S2, leaching coagulator: glove mould is immersed in coagulator, and is dried to the glove mould after leaching coagulator；
S3, purifying natural rubber latex: aluminum hydroxide solution and latex stabilizer are added in natural rubber latex, is sufficiently mixed
And stir, centrifugal concentrating is carried out after stirring, obtains purifying natural rubber latex；
S4, it prepares low protein natural rubber latex: deionized water is added in the purifying natural rubber latex obtained in step s3
It is diluted, then protein denaturation agent solution and polar solvent is added in the natural rubber latex after dilution, obtain low egg
White natural rubber latex；
S5, leaching low protein natural rubber latex: glove mould is immersed in low protein natural rubber latex, and latex temperature is 40-
55 DEG C, dip time 1-3min, after glove mould impregnation is newborn, dry 3-5min under the conditions of 100-125 DEG C；
S6, ultrasonic cleaning: the gloves for having soaked low protein natural rubber latex are immersed in rinse bath and carry out ultrasonic cleaning；
S7, vulcanization: vulcanizing 1-2h in baking oven, and curing temperature is 90-115 DEG C；
S8, washing；
S9, drying, inspection, aseptic packaging are simultaneously put in storage.
2. the production method of safety dipped gloves according to claim 1, which is characterized in that the coagulator in step S2 is
The mixture of calcium chloride, calcium nitrate and water, the mass percent of calcium chloride, calcium nitrate and water is respectively in the mixture
10wt%, 10wt% and 80wt%.
3. the production method of safety dipped gloves according to claim 2, which is characterized in that the hydrogen-oxygen in the step S3
The quality of change aluminum solutions and natural rubber latex is 1-3:50 than range, and the latex stabilizer in the step S3 is sodium hydroxide
Solution.
4. the production method of safety dipped gloves according to claim 3, which is characterized in that the protein denaturant is
One of urea, guanidine hydrochloride, lauryl sodium sulfate, mercaptoethanol are a variety of, and the polar solvent is ethyl alcohol, acetone or third
Glycol it is one or more.
5. the production method of safety dipped gloves according to claim 4, which is characterized in that the protein denaturant is molten
The mass percent range of protein denaturant is 0.05-1.5wt% in liquid.
6. the production method of safety dipped gloves according to claim 5, which is characterized in that further include passing through in step S4
The centrifugation step of impurity in centrifugal device centrifugation removal latex after protein degradation.
7. the production method of safety dipped gloves according to claim 6, which is characterized in that further include to system in step S4
The step of low protein natural rubber latex got ready samples and detects its protein content, when the protein content in latex is higher than
When 50 μ g/g, step S3 and S4 are repeated.
8. the production method of safety dipped gloves according to claim 1, which is characterized in that ultrasonic cleaning in step S4
Supersonic frequency be 15-30KHz.
9. the production method of safety dipped gloves according to claim 8, which is characterized in that the rinse bath includes first
Rinse bath, the second rinse bath and third rinse bath, respectively in the first rinse bath, the second rinse bath and third after gloves ultrasonic cleaning
It is cleaned in rinse bath, the cleaning temperature range of first rinse bath, the second rinse bath and third rinse bath is respectively 45-
55 DEG C, 45-60 DEG C and 40-60 DEG C.
10. a kind of safety dipped gloves, which is characterized in that the safety dipped gloves are used such as any one of claim 1-9 institute
The production method for the safety dipped gloves stated is made.
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Application publication date: 20190611 |