CN109846780A - A kind of liquid tooth paste - Google Patents

Abstract

The present invention relates to technical field of daily necessities, more particularly to a kind of liquid tooth paste, the composition includes fluoride sources and hydroxyapatite, Relative Dentine Abrasivity (the Relative Dentine Abrasivity of liquid tooth paste, RDA) value is 30-50, less than 50.PH is between 7 to 8.3, viscosity: 13600 to 16500mpa.s, specific gravity is 1.02 to 1.6pH.The composition, desensitization are improved with tooth fluoridation and remineralization effect, and invigoration effect can be combined by fluorine ion with sylvite to realize, the pH of the composition belongs to pyrophosphate buffering.

Description

A kind of liquid tooth paste

Technical field

The present invention relates to technical field of daily necessities, and in particular to a kind of liquid tooth paste.

Background technique

Conventional toothpaste is by abrasive material fluoride, detergent and some addition stabilizers composition.The grinding effect of toothpaste is by its RDA Value indicates that tooth can be worn by being often used toothpaste of the RDA greater than 50.

Grinding agent can cause enamel to corrode such as the dentistry polishing agent that dentist's office uses, and referred to as " polishing " acts on.Tooth The polishing agent of tooth eliminates the spot of dental surface, except the effect of plaque and calculus dentalis, is not shown to improve tooth Tooth health.These insoluble granules are declared to reduce decayed tooth and periodontosis to the maximum extent always by businessman extensively.Saprodontia is in fact A kind of multifactorial disease wherein streptococcus lactis and turns the Gram positive aerobics such as sugar chain ball bacterium using oral cavity food residual as nutrition Acid is produced, acid makes lower surface demineraliting (not fully remineralization), causes progressive tissue to be lost, ultimately forms cavity.Bacterial plaque The presence of film is necessary condition, and when carbohydrate easy to ferment, sugar level persistently rises a period of time, acidogenic bactria such as streptococcus mutans Become pathogenic bacteria.Even if acid attack or physical abrasion can lead to and enamel forfeiture occur, these processes are collaborations without illness It carries out.Tissue, which is exposed in acid, after enamel abrasion causes decalcification matter, and surface softening, mineral density is caused to reduce.Normal Under physiological condition, demineraliting tissue carries out self-regeneration by the remineralization effect of saliva.Saliva is saturation to calcium and phosphoric acid, When enamel is not worn, Healthy People, which salivates, to be easy in washing away acid attack, and heightening pH keeps mineral heavy to change balance It forms sediment.When enamel is worn will dental erosion.Dental erosion is the superficial phenomenon of demineraliting, eventually lead to dental surface dissolution (by Acid causes, and does not derive from bacterium).Sour most common source is in diet, such as the orange from fruit or soda, citric acid or Phosphoric acid from beverage and the acetic acid from fragrant juice.The hydrochloric acid (HCl) that gastric reflux generates can also cause dental erosion, and the hydrochloric acid is logical It crosses natural reaction such as gastroesophageal reflux or oral cavity is entered by the induced reaction that bulimia nerovsa patient is subjected to.Odontotripsis can be by grinding Caused by consumption or rubbing agent.It is worn away when dental surface is rubbing against one another, i.e. Two body wear.Three-body-abrasion frequently results in generation Friction, most commonly with to use toothpaste and rubbing agent to brush teeth related.Toothpaste of the RDA lower than 50 is to the enamel to mineralize completely Caused wear levels are reduced to minimum.However, if enamel is exposed under erosion environment demineraliting, softening, tooth Glaze confrontation rubbing agent will become more sensitive.Dentine is softer than enamel, therefore more sensitive to rubbing agent.Dentinal abrasion Exposed people should avoid the toothpaste high using abrasive content, since the softening of corrosional dentine will increase tissue opposite grinding The sensibility of damage.Dentine is usually covered by enamel or cementum in vivo, is respectively referred to the same to root of the tooth for corona.Tooth sheet For matter compared with enamel, the content of organic matter is higher, and structure feature is the tubule for having full of fluid.Wear erosion can be gone Removing coating is engaged mixture and tubule " filler ", and dentine fluid is caused to flow outward so that dentine to environmental stimuli (heat, Cold and pressure) more sensitive ache.

Many tradition whitening toothpastes can all generate temporary whitening effect.These toothpaste contain peroxide or high RDA Abrasive material, can remove spot.Whitening toothpaste by impermeable surface spot or cannot rot to change the natural color of tooth or inverse Discoloration.However, whitening can for good and all reduce the intensity of tooth, make as the process wipes the protectiveness outer layer of enamel off Tooth is impaired.

Conventional toothpaste can be such that taste bud changes.After conventional toothpaste, drinks orange juice and other fruit juice (in addition to apple) have and make us Unhappy taste.Since conventional toothpaste water content is low, activating agent and salt relative enhancement.The activating agent and salt of high concentration destroy mouth Chamber mucosa cells water balance, and phosphatide is easily decomposed, inhibit taste receptors, brings peculiar smell to food.

Conventional toothpaste increases the incidence of certain human mouth ulcer.Conventional toothpaste is aqueous small, activating agent and salt relative concentration It is high.High solution thoroughly seizes Oral Mucosal Cells moisture, so that the protective layer of oral cavity tissue is dried out, leads to the tissue damaged.

Summary of the invention

To solve this problem, the present invention provides a kind of liquid tooth paste for fighting more prevalent dental erosion or odontotripsis problem Composition, the composition include fluoride sources and hydroxyapatite, the Relative Dentine Abrasivity (Relative of liquid tooth paste Dentine Abrasivity, RDA) value be 30-50, less than 50.PH is between 7 to 8.3, viscosity: 13600 to 16500mpa.s, specific gravity is 1.02 to 1.6pH.The composition, desensitization and tooth fluoridation and remineralization act on To raising, invigoration effect can be combined by fluorine ion with sylvite to realize, the pH of the composition belongs to pyrophosphate buffering.

The present invention provides a kind of liquid tooth paste；The liquid tooth paste includes fluoride sources, rubbing agent, activating agent, anti-allergic agent； Wherein, fluoride sources are sodium monofluorophosphate, and rubbing agent is hydroxyapatite and fumed silica, and activating agent is spring chrysanthemum golden aster Extract bisabolol.

Further, aforesaid liquid toothpaste further includes calendula extract.

Further, aforesaid liquid toothpaste further includes anionic surfactant, and wherein anionic surfactant is ten Sodium dialkyl sulfate and lauryl glucosyl.

Further, aforesaid liquid toothpaste further include further include anti-erosion competitor cinnamic acid sylvite.

Further, the antiallergic composition of aforesaid liquid toothpaste is licorice.

Further, aforesaid liquid toothpaste further include further include oral cavity hardening agent niacinamide, wherein its mass percent Score is the 0.1%~0.3% of liquid tooth paste quality gross mass.

Further, aforesaid liquid toothpaste, the water content of the toothpaste are greater than 70%, tooth wear value (RDA) less than 50, PH is between 7 to 8.3, viscosity: 13600 to 16500mpa.s, specific gravity is 1.02 to 1.6.

Further, aforesaid liquid toothpaste includes each raw material of following mass percent: pure water 74.31%, glycerol 12%, propylene glycol 3%, fumed silica 3%, lauryl sodium sulfate 2.5%, lauryl glucosyl 1.5%, single fluorine 0.86% card wave 2020nf0.8% of sodium phosphate, triclosan 0.26%, methylparaben 0.22%, corn carbohydrate gum 0.2% are red not have Medicine alcohol 0.2%, willow leaf calyx canthus 0.2%, pot marigold 0.2%, potassium cinnamate 0.15%, glycyrrhizic acid 0.1%, sodium pyrophosphate 0.1%, Hydroxyapatite 0.1%, Wei jasmine caul-fat 0.1%.Menthyl ester 0.1%, niacinamide 0.05%, vitamin B5,0.05%.

Intentional technical effect of the invention:

Composition of the invention slowly corrodes especially effectively anti-tooth, because tooth can not only be reinforced to protect Teeth against acid attack, and solid again can soften enamel as caused by acid attack.

Due to the low abrasion degree of the present composition, substantial neutral pH, containing micro- inorganic matter for being usually used in oral cavity composition Gas phase rubbing agent.The problem that composition of the invention will not make dental erosion related to odontotripsis is deteriorated.

The effective remineralization of composition of the invention and reinforcing tooth provide to take care of one's teeth and resist dental erosion and odontotripsis and control Treat dental erosion or odontotripsis.

Composition of the invention can also be used for prevention canker sore, periodontosis, bleeding gums and treatment saprodontia or tooth mistake Quick disease.

Suitable fluoride sources used in the present composition are that the high sodium monofluorophosphate fluorine ion amount of safety is 1000-1050ppm.With 0.09-0.1% weight can be contained

After selecting micron order hydroxyapatite and fumed silica and fluorophosphate gelatinization, there is the sliding clean friction of weighing apparatus Power exists in right amount.Guarantee the RDA of toothpaste less than 50.While to ensure that toothpaste suitably cleans tooth, tooth wear is not encouraged, Especially lead to the tooth of softening by dental erosion or by acid attack.

Micron order hydroxyapatite accounts for the 0.1 to 0.2% of total composition weight, and fumed silica accounts for total composition weight 3%.Its friction level the advantage is that not only reduce the wear intensity of toothpaste, and using micron order hydroxyapatite and fluorine from The interaction of son, to improve the utilization rate of free fluorine ion and the remineralization reparation to tooth.

As Surfactant SDS, lauryl glucosyl is combined with active matter bisabolol and is made With in conjunction with micron order hydroxyapatite and fumed silica, the cleaning that can accelerate the removing of tooth mycoderm, especially tooth paulin is made With.

The conjunction content of surfactant is the 3.5%-4.5% of total composition weight.

In order to treat dental hypersensitivity, fluid present invention dentifrice composition contains calendula extract, and willow leaf calyx canthus extracts Object and bisabolol desensitizer.Desensitizer further includes channel blockers or nerve desensitising agent activity hydroxy apatite composite.

Desensitizer can promote the fluoride sources of remineralization of teeth.Natural antiseptic agent sylvite is selected, total composition weight 1.5-2%.

Potassium cinnamate is conducive to enhance clean effect, particularly useful for the formula of low frictional properties, it is believed that low frictional properties Formula have relatively high clean-up performance.

Embodiment

Embodiment 1

The formula percentage composition of liquid tooth paste:

Pure water 74.31%, glycerol 12%, propylene glycol 3%, fumed silica 3%, lauryl sodium sulfate 2.5%, ten Dialkyl group glucoside 1.5%, 0.86% card wave 2020nf0.8% of sodium monofluorophosphate, triclosan 0.26%, methylparaben 0.22%, corn carbohydrate gum 0.2%, bisabolol 0.2%, willow leaf calyx canthus 0.2%, pot marigold 0.2%, potassium cinnamate 0.15%, Glycyrrhizic acid 0.1%, sodium pyrophosphate 0.1%, hydroxyapatite 0.1%, Wei jasmine caul-fat 0.1%.Menthyl ester 0.1%, niacinamide 0.05%, vitamin B5,0.05%.Wherein hydroxyapatite selects the pure substance of 10 micron orders and sodium fluoro phosphate in 44 degree of C high Speed cuts into glued hydroxyapatite

Other compositions are selected from commercial standard producer.

The production method of liquid tooth paste includes four steps: self-dissolving, miscible, filling, sterilization wrap.

It takes fumed silica 3g 1:8 in mass ratio that deionized water is added, is stirred 20min, be added in mixture The hydroxyapatite of 0.1g mixes to get rubbing agent.

A kind of antibacterial liquid tooth paste takes the component in above-mentioned formula to be warming up to 30 DEG C and is stirred 1h according to the mass fraction, Up to liquid tooth paste.

Embodiment 2:

By following test method confirm the fluoride utilization rate of toothpaste of the present invention, the protection to enamel, acid protection effect, Wear intensity and cleaning capacity.

Fluoride utilization rate:

1 part of test toothpaste is homogenized 8 minutes with 3 parts of distilled water and prepares sample.Measure slurries pH, 10,000 rpm from The heart obtains supernatant.Clear liquid is diluted with water, so that fluorinion concentration is in critical field.Using suppressive Conductivity detection ion color Spectrometry analyzes the solution.Analyte concentration is measured by mark method.

Test result: the fluoride utilization rate and pH of various test products, these liquid tooth pastes containing sodium monofluorophosphate are all Show good fluoride utilization rate.

Intake (EFU) of the enamel to fluoride:

According to U.S. Food and Drug Administration (FDA) test operation, EFU test operation is carried out.In the case, make With 0.22%w/v polyacrylic acid 0.1M is contained, lactic acid (pH5.0 adds hydroxyapatite to 50% saturation degree) forms initial damage.

The people's incisor for selecting health, washes all adhesion soft tissues.Tooth is vertically cut with hollow boring bit to labial surface system The enamel axis that standby diameter is 3mm.Sample overheat can be completed under water in order to prevent.Using methacrylate Yue ester by each sample It is embedded into the end of organic glass bar (l/4 " diameter x 2 " is long).Remove excessive acrylic acid, makes enamel surface exposure.Enamel Sample is polished with 600 granularity l Water Papers, then is polished with ultra-fine Y-Shaped aluminium oxide.Then, each enamel sample is immersed into 0.6ml It 15 seconds in 1M perchloric acid, and keeps stirring, is eclipsed enamel specimen.With ionic strength buffer by every kind of sample solution Being buffered to pH is 5.2, determines content of fluoride by compareing the standard curve equally prepared.These data reflect each sample Intrinsic fluoride level before present treatment.

Sample is ground and polished, at room temperature, each enamel specimen is immersed into 0.1M lactic acid/0.2% carbopol 20 hours in solution, initial damage is formed.Then sample wash with distilled water is stored in wet environment use.Sample is immersed (the slurries centrifugal treating for uniformly forming corresponding 1 part of toothpaste afterwards with 3 parts of distilled water, continuously stirs (340rpm) to 22ml supernatant 35 minutes.After cleaning in deionized water, desurfacing measures content of fluoride.Subtracted with fluoride number after each sample treatment Fluoride is inherently horizontal before going to handle, and obtains the variation of content of fluoride in enamel.It is carried out with one-way analysis of variance model Statistical analysis.When showing significant difference, individual mean value is analyzed using multipole difference method of inspection.

Even if 2 groups of liquid tooth paste of actual measurement and all formulas of the EFU result of study of a variety of commercial toothpastes have identical Fluoride source and similar fluoride utilization rate, but in tested product, the liquid tooth paste of 2 tests of the present invention is being counted Outstanding EFU is shown on.

Remineralization and demineraliting test:

In the case where simulation is exposed to the dynamical state of diet acid, evaluation toothpaste with fluoride promotion enamel to the intake of fluoride with And reduce the function of subsequent demineralized.L% citric acid is selected, acidic buffer (with sodium hydroxide tune pH to 3.8) makes and orange The pH of juice is identical.

With the enamel specimen (3mm diameter, n=18) of EFU method preparation embedding.They are used as healthy sample or slightly invade Lose sample.Using Vickers micro hardness tester (load 200g is stopped 16 seconds), measure surface hardness (SMH).From each sample surfaces On impression everywhere measure average sample hardness, with Vickers hardness number (VNH) indicate.

Each sample is placed in 6.0ml citrate buffer solution the acid resistance for stirring 10 minutes to evaluate enamel.Again by sample Product immerse in 12ml citrate buffer solution stands 18 minutes again.SMH is measured again, according to the SMH after erosion by aching and limpization sample point At several groups.Mixed people's saliva and the artificial saliva buffer containing mucoprotein are used as cyclic test with 50:50 mixture Remineralization medium.Include gastric mucin, sodium chloride, chloride dehydrate calcium, potassium dihydrogen phosphate and potassium chloride.It is collected from five people People's saliva of wax stimulation, mixing, freezing use.Then it is vigorously stirred mixing saliva sample, saliva sample is assigned into 30ml and is burnt Cup.Use fresh saliva and mineral mixed liquor.

During processing, sample is immersed in liquid tooth paste slurries, it is daily to brush teeth.It is added in beaker with 5.0g liquid tooth paste In 10g fresh saliva and mineral mixed solution, slurries are prepared with magnetic stirrer.Preceding fresh slurry is just prepared per treatment Liquid.Round-robin method includes the process phase of 5x2 minutes acid attack phases and 3x2 minutes.After processing, with the distilled water cleaning sample of flowing, Then processing sample is replaced with saliva.SMH is measured after 12 days and 24 days circulations.The processing time for the test is as follows:

After result of study shows processing in 20 days:

When SMH micro-hardness data shows 12 days and 24 days, the not control of fluoride relatively, the liquid tooth of test 2 Cream and commercially available brand mothproof toothpaste have statistical significant difference in terms of the enamel sample softening for preventing acid from intervening.? At 12 days and 24 days, the liquid tooth paste of test 2 statistically shows that brilliant protection is made than commercially available brand mothproof toothpaste With.During research, 7060 liquid tooth pastes of test 2 embody net increase compared to the SMH of damage.It is aobvious that fluoride absorbs data Show, the liquid tooth paste of test 2 is compared than commercially available brand mothproof toothpaste can more promote fluoride to absorb.

Experimental study demonstrates in terms of protection enamel resists surface softening, and the liquid tooth paste of test 2 is in statistics Upper to be better than commercially available brand mothproof toothpaste, body is research shows that the enamel of damage can be reinforced again.Sour degree of protection is taken the photograph with sample The fluoride degree taken is positively correlated, this proves that the liquid tooth paste for testing 2 absorbs fluoride and can protect the sour demineraliting of resistance, with And it improves and promotes more effective remineralization.

Generally speaking, in vitro study, which demonstrates composition of the invention and damaged caused by the anti-diet acid attack repeatedly, above mentions Outstanding level of protection is supplied.

External sclerous tissues wear testing:

Dentine or enamel specimen are placed in neutron flux, make controllably to generate radioactivity 32P in sample.By sample packet In methylmethacrylate, so that they are fixed in V-8 transverse direction Tooth-brushing device.Using slurries (50ml 0.5), carboxymethyl is fine Dimension is plain, and includes 10g pyrophosphoric acid dicalcium in glycerite, brushes teeth this quality sample 1500 times, enamel 5000 times pretreatments.It will Slurries are used as intrinsic reference standard.The toothbrush used is American Dental Association (ADA) specified, load 150g.After pretreatment, Toothbrush in the slurries of design using load 150g brushes teeth essence 1450 times or enamel 4950 times and is tested, every kind of examination Testing slurries, (20g liquid tooth paste adds 35ml water reference slurries (10g/50ml 0.5%CMC) in centre.Water compares 50ml water.Work as brush When tooth, the particle of enamel or dentin surface is ground into slurries of brushing teeth.Whole point of slurries are diluted with scintillating medium, use sudden strain of a muscle Bright meter measurement radioactivity, i.e., the 32P lost in sample.

The front and back net value that reference material tests every kind slurries is calculated, average is calculated.Slurries mean value is tested to reference mean value Ratio calculate RDA.Test slurries obtain RDA value multiplied by normal 100 to the ratio of reference slurries.

The liquid tooth paste of test 2 and the external wear intensity of a variety of commercial toothpastes are listed respectively, test the RDA knot of acquisition Fruit.In tested toothpaste, the liquid tooth paste of test 2 shows minimum RDA, this shows low-down sclerous tissues' abrasion.

The experiment shows that further research has shown that enamel can be reinforced and be hardened to composition of the invention, can be used to protect The treatment of tooth resistance dental erosion and odontotripsis

The enamel surface softening of citric acid intervention:

The SMH of 20 healthy enamel samples is tested, and sample is randomly assigned as 4 processing groups.It measures respectively each The SMH numerical value of sample, the automatic control as it compare.Sample immersion is spent in the standby liquid tooth paste slurries (1:3) of ion water making Stirring 100 seconds.Then deionized water cleaning sample is used, is poured into citric acid (pH 3.75) 30 minutes.It was taken out every 10 minutes Sample after cleaning residual acid in deionized water, measures SMH.

Measurand shows that enamel surface softens result of study.SMH value versus baseline is made into standard processing.All Time point, the opposite sample with commercial toothpastes and the control treatment of non-fluoride, with test(ing) liquid toothpaste and commercial toothpastes tooth The acid of cream causes surface to soften sample, and softening degree is statistically substantially reduced.Behind 25 minutes and 25 minutes, test Liquid tooth paste is compared with commercial toothpastes toothpaste, and the surface softening degree of acid intervention is inhibited statistically to be better than commercially available tooth Cream

Summarize enamel surface softening modulus method, it was demonstrated that composition of the invention can protect enamel to resist erosion, therefore It can provide protection and resist dental erosion and odontotripsis.

It rehardens after damage:

20 healthy enamel samples are immersed into the damage of erosion in 30 minutes in the citric acid solution (pH 3.75) of 10ml 1.0% Wound test.Then SMH baseline is measured, sample is randomly assigned into 4 processing groups (n-5).The SMH of each sample is measured respectively Value is used as automatic control and compares.Sample immersion is spent into stirring 100 seconds in the standby liquid tooth paste slurries (1:3) of ion water making.It spends again Ionized water cleaning sample is placed in the artificial saliva containing corresponding liquid tooth paste slurries and does not intend body absorption.

Using the original liquid lotion of gradually high dilution, simulation in several minutes after liquid tooth paste and a few hours saliva using depositing Absorption strength carry out three separated tests.Manually saliva presses the diluted lotion of 1:1396 for selection.Dilution is so that saliva Fluoride concentration is about 1ppm in liquid.4 example dilutions of next examination are so that fluoride is final concentration of about in artificial saliva 0.04ppm and 0.02ppm. measures the degree that rehardens of sample after soaking in artificial saliva 5 hours, 20 hours and 40 hours

Remineralization hardness data shows that its degree of rehardening of the liquid tooth paste processing group of test is statistically better than institute There are all processing groups of other commercial toothpastes compared with baseline, erosion damages of rehardening statistically show significant difference.? All time points, its degree of rehardening of the liquid tooth paste processing group of test are statistically better than market brand anti-anaphylaxis toothpaste

Test shows that microhardness research has shown that liquid tooth paste of the invention can inhibit as caused by citric acid Enamel surface softening, and the reparation of enamel erosion damages can be promoted.

Decontamination efficacy test:

Two different methods have been used in the present experiment, have carried out the soil release performance of comparison composition of the invention and several commercial toothpastes Energy.

Pellicle cleans ratio:

PCR is substrate using the bovine-enamel of incision, polishing and acid attack, manually catches incorporation diet chromogen and adds lustre to carefully The compound of bacterium.All PCR tests are carried out as described in Stookey.

1. the fluid present invention toothpaste of measurement and the PCR value of commercially available brand toothpaste.

2. 7060 liquid tooth paste of the present invention of measurement and the PCR value of commercially available high definition prophy paste.

For cleaning capacity, without statistical significant difference.

Exogenous decontamination (NESR) method

Ox front tooth hat will be cut, removal dental pulp is washed and dried in deionized water.120g self-healing acrylic acid is repaired into material Feed powder end and 45g self-healing liquid acrylic are mixed with propylene acid solution.It is 3.6 centimetres that the mixture of acquisition, which pours into diameter, high by 1.6 Centimetre bottle cap.Tooth, which is pushed into mixture, to be ensured and the close level in surface.It is intermediate that all teeth are immersed in lid.

The tooth of leaching is placed in trough of brushing teeth, toothbrush moves back and forth up and down between tooth.In toothbrush load 110g situation Under, brush speed is 100 times per minute circulations.Remove unstable spot.Tooth is taken out, cleans, then air-dried in water Night.

Use the spot on colorimeter parameter evaluation tooth.Every five flat positions point of every tooth surrounding is taken to read. After each processing group is brushed teeth in advance at random, the value range of tooth is 48-90.

Liquid tooth paste of the invention respectively with the resulting NESR value of commercially available brand toothpaste.Show its dirt-removing power better than other Toothpaste 3%.

Although being not significantly different in level, data also provide some information, and to show that liquid tooth paste of the invention surpasses commercially available Brand toothpaste (liquid tooth paste brush of the invention for the first time can decontamination 38%, and use commercially available brand Tooth paste brush first time can decontamination 35%).

In general for the product with low abrasion degree, the detergency ability of liquid tooth paste of the invention is high.It is former Because being in being formulated that there are sylvite and pyrophosphate.It is to cause effect to increase due to there is opposite high dissolubility complex, also It is to say, due to the presence of acid ion, some calcium in spot are discharged into solution, to increase clean effect.

To canker sore, periodontosis, bleeding gums, the treatment of toothache:

In November, 2017 between in October, 2018 to 54 suffer from canker sore (including 22 be not used before often recurrence Person), using three days healing person 43 after liquid tooth, 5 days healing persons 9,22 using no longer multiple after preceding frequent recidivist's use Hair.There are 20 periodontosis, bleeding gums, have a toothache compound patient 26, wherein using improving 21 of state after liquid tooth paste.

Claims (10)

1. a kind of liquid tooth paste, which is characterized in that the liquid tooth paste includes fluoride sources, rubbing agent, activating agent, anti-allergic agent； Wherein, fluoride sources are sodium monofluorophosphate, and rubbing agent is hydroxyapatite and fumed silica, and activating agent is spring chrysanthemum golden aster Extract bisabolol.

2. liquid tooth paste according to claim 1, which is characterized in that further include calendula extract.

3. liquid tooth paste according to claim 2, which is characterized in that further include anionic surfactant, wherein yin from Sub- surfactant is lauryl sodium sulfate and lauryl glucosyl.

4. liquid tooth paste according to claim 3, which is characterized in that further include anti-erosion competitor cinnamic acid sylvite.

5. liquid tooth paste according to claim 1, which is characterized in that the antiallergic composition is licorice.

6. -5 any liquid tooth paste according to claim 1, which is characterized in that it further include oral cavity hardening agent niacinamide, In, its mass percent score is the 0.1%~0.3% of liquid tooth paste quality gross mass.

7. -5 any liquid tooth paste according to claim 1, which is characterized in that the water content of the toothpaste is greater than 70%, Tooth wear value (RDA) less than 50, pH between 7 to 8.3, viscosity: 13600 to 16500mpa.s, specific gravity is 1.02 to 1.6.

8. -5 any liquid tooth paste according to claim 1, which is characterized in that the liquid tooth paste further includes thickener, institute State the carbomer that thickener is corn carbohydrate gum or pharmaceutical grade；Amount of thickener is the 1-1.5% of total composition weight.

9. -5 any liquid tooth paste according to claim 1, which is characterized in that the liquid tooth paste further includes wetting agent, institute Belonging to wetting agent is 1,2 propylene glycol and glycerine, and humectant content is composition weight

10-15%.

10. liquid tooth paste described in -5 according to claim 1, which is characterized in that the toothpaste includes following mass percent Each raw material: pure water 74.31%, glycerol 12%, propylene glycol 3%, fumed silica 3%, lauryl sodium sulfate 2.5%, ten Dialkyl group glucoside 1.5%, 0.86% card wave 2020nf0.8% of sodium monofluorophosphate, triclosan 0.26%, methylparaben 0.22%, corn carbohydrate gum 0.2%, bisabolol 0.2%, willow leaf calyx canthus 0.2%, pot marigold 0.2%, potassium cinnamate 0.15%, Glycyrrhizic acid 0.1%, sodium pyrophosphate 0.1%, hydroxyapatite 0.1%, Wei jasmine caul-fat 0.1%.Menthyl ester 0.1%, niacinamide 0.05%, vitamin B5,0.05%.