CN109841489B - Device for reducing discrimination of transmission quality of radio frequency quadrupole rods - Google Patents
Device for reducing discrimination of transmission quality of radio frequency quadrupole rods Download PDFInfo
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- CN109841489B CN109841489B CN201711203282.5A CN201711203282A CN109841489B CN 109841489 B CN109841489 B CN 109841489B CN 201711203282 A CN201711203282 A CN 201711203282A CN 109841489 B CN109841489 B CN 109841489B
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Abstract
The invention provides a device for reducing the discrimination of the transmission quality of a radio frequency quadrupole rod. Based on the quadrupole transmission principle, the radio frequency power supplies with different frequencies and amplitudes have different transmission quality ranges. In order to reduce the mass discrimination effect, different radio frequency power supplies are respectively applied to two adjacent electrodes in the segmented quadrupole rod electrode array, two alternating radio frequency electric fields are generated in the whole transmission axis direction, and meanwhile, the transmission of ions with mass-to-charge ratios in two mass ranges is considered, so that the mass discrimination effect is reduced.
Description
Technical Field
The invention relates to the field of mass spectra, and particularly provides a device for reducing discrimination of transmission quality of a radio frequency quadrupole rod. Based on the quadrupole transmission principle, a radio frequency power supply with certain frequency and amplitude has a fixed maximum mass transmission range, and ions with too large and too small mass-to-charge ratios are difficult to transmit through the quadrupole.
Background
When a classical radio frequency quadrupole rod operates in an rf-only mode, a radio frequency electric field restrains ions and neutral background gas molecules from colliding continuously to exchange energy and cooling gradually, so that the ions can be effectively focused to pass through the pores of the next stage, and the ion transmission efficiency is greatly improved. This has been fully reported in "colloidal focusing effects in radio frequency standards" published by Douglas in 1991. However, one problem with this transmission is that: the same direct current potential is applied to four rods of the radio frequency quadrupole rods, so that a certain gradient exists between the electric fields at the two end parts of the quadrupole rods and the end cover electrodes, and forward transmission of ions is facilitated; however, the electric field variation in the central portion of the quadrupole is extremely weak, substantially similar to a field-free region. This results in a long time for ions entering the quadrupole to pass through.
In view of the above problems, US 006111250a proposes a segmented quadrupole rod design, in which an axial electric field is introduced to adjacent electrodes in a manner of dividing voltage by resistors or in a manner of adding inclined electrode rods around the quadrupole rod, so as to increase the electric field in the direction of the ion flight axis and improve the ion transmission performance.
The classical radio frequency quadrupole rod and the segmented quadrupole rod both adopt a single radio frequency power supply parameter mode to determine a mass-to-charge ratio range interval which is possible to transmit. Ions with too large or too small mass-to-charge ratios cannot stably pass through the quadrupole rods, and the detection range is limited.
Disclosure of Invention
The invention provides a device for reducing the discrimination of the transmission quality of a radio frequency quadrupole rod. Based on the quadrupole transmission principle, the radio frequency power supplies with different frequencies and amplitudes have different transmission quality ranges. In order to reduce the mass discrimination effect, different radio frequency power supplies are respectively applied to two adjacent electrodes in the segmented quadrupole rod electrode array, two alternating radio frequency electric fields are generated in the whole transmission axis direction, and meanwhile, the transmission of ions with mass-to-charge ratios in two mass ranges is considered, so that the mass discrimination effect is reduced.
In order to achieve the purpose, the invention adopts the technical scheme that:
an apparatus for reducing discrimination of transmission quality of a radio frequency quadrupole, comprising: comprises an inlet electrode, an outlet electrode and a segment electrode; the lead-in hole electrode and the lead-out hole electrode are both flat electrodes with through holes in the middle, and the lead-in hole electrode and the lead-out hole electrode are parallel and the central through holes are coaxially arranged; a segment electrode is arranged between the inlet hole electrode and the outlet hole electrode; the segmented electrodes are composed of four groups of electrode arrays; each group of electrode arrays consists of four or more than five cylindrical or circular electrodes which are coaxially arranged at equal intervals and have the same shape and size to form an electrode rod; the head end face and the tail end face of each of the four electrode rods are respectively positioned on two parallel planes, and the intersection points of the axes of the four electrode rods on each plane are uniformly distributed on the circumference of the same circle; and the center of the circle is positioned on the axis of the central through hole of the lead-in hole electrode and the lead-out hole electrode.
A method for reducing transmission quality discrimination using said apparatus, characterized by:
applying DC1 and DC2 direct current voltages to the inlet electrode and the outlet electrode respectively;
applying direct-current voltage to the head end and the tail end of a concentric cylinder or circular ring electrode on any one of four groups of electrode arrays of the segmented electrodes, and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group by voltage dividing resistors to be connected in series; respectively applying n different radio frequency voltages on the cylindrical or circular ring electrodes in the sequence of the sequence numbers from 1 to n through capacitive coupling from the head end, recalculating the sequence numbers again and repeating the application process of the radio frequency voltages in the sequence of the sequence numbers from 1 to n until the tail end; n is an integer greater than or equal to 2, and the number of concentric cylindrical or circular ring electrodes on any one of the four groups of electrode arrays of the segmented electrodes is an integral multiple of more than 2 of n;
one pair of electrode arrays arranged oppositely at intervals in the four groups of electrode arrays is connected with the positive phase output of the radio frequency voltage, and the other group of electrode arrays arranged oppositely applies the negative phase output connected with the radio frequency voltage;
the ion beam with certain energy passes through the lead-in hole electrode and enters the area of the sectional electrode, the ions pass through under the action of the alternating radio frequency electric field, and finally are led out from the central small hole of the lead-out hole electrode.
Applying DC1 and DC2 direct current voltages to the inlet electrode and the outlet electrode respectively;
applying direct-current voltage to the head end and the tail end of a concentric cylinder or circular ring electrode on any one of four groups of electrode arrays of the segmented electrodes, and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group by voltage dividing resistors to be connected in series; and the odd-numbered cylindrical or circular electrodes from the head end to the tail end are respectively applied with radio frequency voltage RF2 through capacitive coupling, the corresponding frequency is W2, and the amplitude is V2; the even numbered cylinders or rings respectively apply radio frequency voltage RF1 through a capacitive coupling electrode, the corresponding frequency is W1, and the amplitude is V1;
one pair of the four sets of electrode arrays, which are oppositely arranged at intervals, is connected with the positive phase output of the radio frequency voltage RF1 or RF2, and the other set of electrode arrays, which are oppositely arranged, is applied with the negative phase output connected with the radio frequency voltage RF1 or RF 2.
Drawings
Fig. 1 is a schematic diagram of an apparatus for reducing rf quadrupole transmission quality discrimination according to the present invention.
FIG. 2 is a simulation of ion transport effect by SIMION software. The mass to charge ratios m/z 30 and m/z200 are compared to the transmission mode of the present invention in a conventional transmission mode with a single rf power supply. (a) The transmission efficiency of m/z 40300V 1500KHz is 0 percent; (b) the transmission efficiency of m/z 200300V 1500KHz is 100%; (c) the transmission efficiency of m/z 40300V 1500KHz and 50V 4000KHz is 98 percent; m/z is 200; (d) the transmission efficiency of 300V 1500KHz and 50V 4000KHz is 99%.
Detailed Description
Fig. 1 is a schematic structural diagram of the present invention. The invention comprises an inlet electrode 1, an outlet electrode 2, a segment electrode 3; the lead-in hole electrode 1 and the lead-out hole electrode 2 are both flat electrodes with through holes in the middle, the lead-in hole electrode 1 and the lead-out hole electrode 2 are parallel and the central through holes are coaxially arranged; a segment electrode 3 is arranged between the inlet electrode 1 and the outlet electrode 2; the segmented electrode 3 is composed of four groups of electrode arrays; each group of electrode arrays consists of four or more than five cylindrical or circular electrodes which are coaxially arranged at equal intervals and have the same shape and size to form an electrode rod; the head end face and the tail end face of each of the four electrode rods are respectively positioned on two parallel planes, and the intersection points of the axes of the four electrode rods on each plane are uniformly distributed on the circumference of the same circle; and the center of the circle is positioned on the axis of the central through hole of the lead-in hole electrode 1 and the lead-out hole electrode 2.
A method for reducing transmission quality discrimination using said apparatus, characterized by:
applying DC1 and DC2 direct current voltages to the inlet electrode 1 and the outlet electrode 2 respectively;
applying direct current voltage to the head and tail ends of concentric cylinder or circular ring electrodes on any one of four groups of electrode arrays of the segmented electrode 3, and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group into series by voltage dividing resistors; respectively applying n different radio frequency voltages on the cylindrical or circular ring electrodes in the sequence of the sequence numbers from 1 to n through capacitive coupling from the head end, recalculating the sequence numbers again and repeating the application process of the radio frequency voltages in the sequence of the sequence numbers from 1 to n until the tail end; n is an integer greater than or equal to 2, and the number of concentric cylindrical or circular electrodes on any one of the four groups of electrode arrays of the segmented electrodes 3 is an integral multiple of more than 2 of n;
one pair of electrode arrays arranged oppositely at intervals in the four groups of electrode arrays is connected with the positive phase output of the radio frequency voltage, and the other group of electrode arrays arranged oppositely applies the negative phase output connected with the radio frequency voltage;
an ion beam with certain energy passes through the lead-in hole electrode 1 and enters the area of the sectional electrode 3, ions pass through under the action of the alternating radio frequency electric field, and finally are led out from a central small hole of the lead-out hole electrode 2.
Applying DC1 and DC2 direct current voltages to the inlet electrode 1 and the outlet electrode 2 respectively;
applying direct current voltage to the head and tail ends of concentric cylinder or circular ring electrodes on any one of four groups of electrode arrays of the segmented electrode 3, and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group into series by voltage dividing resistors; and the odd-numbered cylindrical or circular electrodes from the head end to the tail end are respectively applied with radio frequency voltage RF2 through capacitive coupling, the corresponding frequency is W2, and the amplitude is V2; the even numbered cylinders or rings respectively apply radio frequency voltage RF1 through a capacitive coupling electrode, the corresponding frequency is W1, and the amplitude is V1;
one pair of the four sets of electrode arrays, which are oppositely arranged at intervals, is connected with the positive phase output of the radio frequency voltage RF1 or RF2, and the other set of electrode arrays, which are oppositely arranged, is applied with the negative phase output connected with the radio frequency voltage RF1 or RF 2.
Examples
The segmented electrodes are respectively composed of four groups of parallel electrode arrays; each group of electrode arrays consists of 25 concentric cylindrical electrodes at uniform intervals, and the diameter of each cylinder is 12 mm; the centers of the four groups of electrode arrays are uniformly arranged on the circumference with the radius of 11.3 mm; the thickness of the cylindrical electrodes is 3mm, and the interval is 0.5 mm. The electrode of the leading-in electrode hole and the electrode of the leading-out electrode hole are both circular ring electrodes with the inner diameter of 2mm, the outer diameter of 40mm and the thickness of 2 mm. Applying 35V and 15V direct current voltage to the inlet hole electrode and the outlet hole electrode respectively; the concentric cylindrical electrodes on any one group of the four groups of electrode arrays of the segmented electrodes are uniformly divided by voltage dividing resistors, the cylindrical electrodes conforming to the odd serial numbers are respectively applied with a radio frequency power supply RF2 (with the frequency of 1500KHz and the amplitude of 300V) through capacitive coupling, and the cylindrical electrodes conforming to the even serial numbers are respectively applied with a radio frequency power supply RF1 (with the frequency of 4000KHz and the amplitude of 50) through capacitive coupling electrodes; one of the four sets of oppositely disposed electrode arrays is connected to the positive output of the RF power source RF1 or RF2, and the other set of orthogonally oppositely disposed electrode arrays is applied to the negative output of the RF power source RF1 or RF 2.
The ion transport effect was simulated in SIMION. At the air pressure of 0.8Pa, ions (m/z 40 and m/z200) with the energy of 50eV pass through the leading-in hole electrode and enter the area of the segmented electrode, and the ions can be effectively led out from the central small hole of the leading-out hole electrode under the action of the alternating radio frequency electric field. As shown in FIG. 2, when a single-frequency RF power is applied to all the electrodes, the ion transmission efficiency of m/z40 is 0, and the efficiency of m/z200 is 100%; when RF1 and RF2 were applied to adjacent electrodes, respectively, the m/z40 ion transport efficiency was 98% and the m/z200 efficiency was 99%.
Claims (2)
1. An apparatus for reducing discrimination of transmission quality of a radio frequency quadrupole, comprising: comprises an inlet electrode (1), an outlet electrode (2) and a segment electrode (3); the lead-in hole electrode (1) and the lead-out hole electrode (2) are both flat electrodes with through holes in the middle, the lead-in hole electrode (1) and the lead-out hole electrode (2) are parallel, and the central through holes are coaxially arranged; a segment electrode (3) is arranged between the inlet electrode (1) and the outlet electrode (2); the segmented electrode (3) is composed of four groups of electrode arrays; each group of electrode arrays consists of four or more than five cylindrical or circular electrodes which are coaxially arranged at equal intervals and have the same shape and size to form an electrode rod; the head end face and the tail end face of each of the four electrode rods are respectively positioned on two parallel planes, and the intersection points of the axes of the four electrode rods on each plane are uniformly distributed on the circumference of the same circle; the center of the circle is positioned on the axis of the central through hole of the lead-in hole electrode (1) and the lead-out hole electrode (2);
DC1 and DC2 direct current voltages are respectively applied to the inlet hole electrode (1) and the outlet hole electrode (2);
applying direct current voltage to the head end and the tail end of a concentric cylinder or circular ring electrode on any one of four groups of electrode arrays of the segmented electrodes (3), and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group by voltage dividing resistors to be connected in series; respectively applying n different radio frequency voltages on the cylindrical or circular ring electrodes in the sequence of the sequence numbers from 1 to n through capacitive coupling from the head end, recalculating the sequence numbers again and repeating the application process of the radio frequency voltages in the sequence of the sequence numbers from 1 to n until the tail end; n is an integer greater than or equal to 2, and the number of concentric cylindrical or circular electrodes on any one of the four groups of electrode arrays of the segmented electrodes (3) is an integral multiple of more than 2 of n;
one pair of electrode arrays arranged oppositely at intervals in the four groups of electrode arrays is connected with the positive phase output of the radio frequency voltage, and the other group of electrode arrays arranged oppositely applies the negative phase output connected with the radio frequency voltage;
an ion beam with certain energy passes through the lead-in hole electrode (1) and enters the area of the segmented electrode (3), ions pass through under the action of the alternating radio frequency electric field, and finally are led out from a central small hole of the lead-out hole electrode (2).
2. The apparatus of claim 1, wherein the means for reducing rf quadrupole transmission quality discrimination comprises:
DC1 and DC2 direct current voltages are respectively applied to the inlet hole electrode (1) and the outlet hole electrode (2);
applying direct current voltage to the head end and the tail end of a concentric cylinder or circular ring electrode on any one of four groups of electrode arrays of the segmented electrodes (3), and uniformly dividing the voltage between the adjacent concentric cylinder or circular ring electrodes on any one group by voltage dividing resistors to be connected in series; and the odd-numbered cylindrical or circular electrodes from the head end to the tail end are respectively applied with radio frequency voltage RF2 through capacitive coupling, the corresponding frequency is W2, and the amplitude is V2; the even numbered cylinders or rings respectively apply radio frequency voltage RF1 through a capacitive coupling electrode, the corresponding frequency is W1, and the amplitude is V1;
one pair of the four sets of electrode arrays, which are oppositely arranged at intervals, is connected with the positive phase output of the radio frequency voltage RF1 or RF2, and the other set of electrode arrays, which are oppositely arranged, is applied with the negative phase output connected with the radio frequency voltage RF1 or RF 2.
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