CN109822882A - A kind of part modification biochemical molecular layer method for micro sensor devices - Google Patents
A kind of part modification biochemical molecular layer method for micro sensor devices Download PDFInfo
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- 238000012986 modification Methods 0.000 title claims abstract description 55
- 230000004048 modification Effects 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims abstract description 47
- 239000002052 molecular layer Substances 0.000 title claims abstract description 31
- 238000006073 displacement reaction Methods 0.000 claims abstract description 45
- 230000007613 environmental effect Effects 0.000 claims abstract description 20
- 238000007639 printing Methods 0.000 claims description 30
- 239000007788 liquid Substances 0.000 claims description 21
- 239000007921 spray Substances 0.000 claims description 20
- 238000007789 sealing Methods 0.000 claims description 12
- 239000002699 waste material Substances 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
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- 238000010438 heat treatment Methods 0.000 claims description 3
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- 230000035945 sensitivity Effects 0.000 abstract description 6
- 238000011897 real-time detection Methods 0.000 abstract description 4
- 238000002715 modification method Methods 0.000 abstract 1
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- 239000002975 chemoattractant Substances 0.000 description 2
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Abstract
The invention discloses a kind of part modification biochemical molecular layer methods for micro sensor devices.It is characterized by: will be identical or be different biochemical molecular and be printed upon specific region by the method for micro- ink-jet, the modification of local biochemical functionization is carried out to senser element surface, it is made to meet biochemistry detection demand.This is used for the method for modifying of local biochemical molecular layer, and device includes: a piezoelectric type mini sprinkler, its printed droplets size can be controlled by voltage；Two cameras are used for three dimensional viewing mini sprinkler and device position；One XY displacement platform, device are placed on workbench and can move in the horizontal plane with XY displacement platform；One closed container, for holding the biochemical molecular printed；One closed container pressure control unit, for adjusting air pressure size in closed container；One XY displacement platform data acquistion and control system, can be with the direction precisely controlling displacement platform XY moving displacement；One mini sprinkler control unit is used to regulation and control printed droplets size, drop number and state；One environmental Kuznets Curves and measuring unit, for measuring ambient environmental conditions.The high sensitivity to biochemical molecular to be measured, high stability, high-throughput real-time detection can be effectively realized by the local biochemical molecular modification method that micro- ink discharge device carries out.
Description
Technical field
The invention belongs to semiconductor, biochemistry and engineering field more particularly to a kind of offices for micro sensor devices
The method of domain modification biochemical molecular layer.
Background technique
Application with biochemical sensor in fields such as food, medicine, environment and process monitorings constantly expands [1-2], right
The performance of biochemical sensor proposes requirements at the higher level: high sensitivity, high stability, low cost etc..Otherwise for medical diagnosis on disease,
The fields such as food inspection, environmental monitoring application demand, the development of biochemical sensor show following trend: multifunction: passing through
Develop Multifunction Sensor using technologies such as interference, three-dimensional high-speed solid ink-jet [3], self assemblies, on area as small as possible
Arrange sensor as much as possible；Miniaturization: the appearance of various portable biochemical sensors makes people carry out disease at home to examine
Break, directly detection food is possibly realized on the market；It is integrated with it is intelligent: exploitation have the function such as detection, judgement, information processing concurrently
The sensor of energy realizes automated detection system, will realize detection process with the biochip system that chip turns to structure feature
Integration, intelligence；Low cost, highly sensitive, high accuracy and high stability: biochemical sensor, must to move towards market
Cost must be reduced, detection sensitivity, Stability and veracity are improved.So being directed to the detection of biochemical molecular sensitive layer, compel to be essential
A kind of method for proposing local decorated biochemical molecular layer for micro sensor devices.
Easily measurement error is caused to be always highly sensitive biochemistry detection for the absorption of a large amount of biochemical moleculars and non-accurate modification
Research hotspot.Research about this respect is never interrupted and researchers want always the technological difficulties broken through.Such as 1995
Year, [4] are studied in the influence that T.Thundat takes the lead in regard to adsorption to mechanical micro-cantilever frequency.In V-type
Layer of Au film is evaporated above SiN micro-cantilever, is used for specific adsorption Hg steam.The study found that in specific adsorption process
In other than the effective mass of micro-cantilever changes, under the action of surface stress, the stiffness factor of the micro-cantilever of V-type
K is also changed, and is not reduced with the extension of reaction time so as to cause resonance frequency, is constantly increased instead.When only
When Au film is evaporated close to the part of free end in micro-cantilever surface, rear surface stress variation is reacted with Au due to avoiding Hg
The change of caused stiffness factor k, with the extension of reaction time, the resonance frequency of micro-cantilever reduces as expected.This hair
The research of huge detection error is caused to influence to be huge referring now to a large amount of biochemical molecular absorption and non-accurate modification is eliminated.
So far, breakthrough is had been achieved for the research of biochemical sensor both at home and abroad, but there are still many
Technical problem, such as:, can be because large area absorption leads to measurement error when biochemical sensor carries out large area modification to biochemical molecular
It is larger.Therefore, there is an urgent need to propose a kind of part modification biochemical molecular layer method for micro sensor devices.It is treated with realizing
Survey biochemical molecular high sensitivity, high stability, high-throughput real-time detection, realize to need to locally modify device it is accurate printing with
It is extensive local decorated, reduce the modification cost of micro biochemical molecule.
Bibliography
[1] C.N.Jayarajah and M.Thompson, " Signaling of transcriptional
Chemistry in the on-line detection format, " Biosensors and Bioelectronics,
Vol.17, pp.159-171,2002.
[2] J.Kirsch, C.Siltanen, Q.Zhou, et al., " Biosensor technology:recent
Advances in threat agent detection and medicine, " Chemical Society Reviews,
Vol.42, pp.8733-68,2013.
[3] S.Salomon, T.D.Dezest, et al., " Arrays of
Nanoelectromechanical biosensors functionalized by microcontact printing, "
Nanotechnology, vol.23, p.495501,2012.
[4] T.Thundat E.A.Wachter, S.L.Sharp, et al., " Detection of mercury vapor
Using resonating microcantilevers, " Applied Physics Letters, vol.66, pp.1695-
1697,1995.
Summary of the invention
(1) technical problems to be solved
In order to realize the high sensitivity to biochemical molecular to be measured, high stability, high-throughput real-time detection, biochemical molecular is completed
Micro accurate modification, need biochemical molecular to be detected because a large amount of biochemical moleculars adsorb and it is non-it is accurate modification cause detection error
Etc. carry out technological break-through, the invention proposes it is a kind of for micro sensor devices part modification biochemical molecular layer method.
The modification of local biochemical molecular layer is carried out to specific region using micro sensor devices in biochemical molecular detection, can be eliminated because a large amount of
In addition biochemical molecular absorption and non-accurate modification bring measurement error carry out local modification with the method for micro- inkjet printing, can
To realize region and the dosage of accurate controlled modification, so that reducing biochemical molecular by part modification prints cost.
(2) technical solution
High sensitivity, high stability, high-throughput detection in real time carried out to testing molecule in order to realize, realization is to need to locally repair
The accurate printing of frilled organ part reduces the modification cost of micro biochemical molecule, and the invention proposes one kind to be used for micro sensor devices
Local decorated biochemical molecular layer method, this method be suitable for the device of various specifications carry out printing and extensive local
Modification protocols, comprising: a piezoelectric type mini sprinkler, for printing the biochemical molecular being modified；One gas pressure regulator, for control and
Adjust air pressure size in closed container；One closed container by printing includes biochemical molecular solution for holding, and passes through conduit point
It is not connected with gas pressure regulator and piezoelectric type mini sprinkler, realizes the level control to piezoelectric type spray head；One piezoelectric type mini sprinkler control
System processed, for regulation and control printed droplets size, drop number and state；One two dimension or three-dimensional working platform, are beaten for placing
Print device and the rotation of control device in the original location；One XY displacement platform, two dimension or three-dimensional working platform are placed in high precision displacement
On XY displacement platform, XY displacement platform can be followed to move in the horizontal plane；One XY displacement platform data acquistion and control system, passes through software
Program accurately controls the direction displacement platform XY moving displacement；Two cameras, respectively from X and Y-direction three dimensional viewing mini sprinkler and
Device position and drop print situation；One environmental Kuznets Curves and measuring unit, for controlling and detecting biochemical molecular print procedure
Needed for be suitble to environmental condition, the environmental condition includes temperature and humidity.
In above scheme, two cameras are fixed on an inverted U bracket by L-type foot prop, wherein a camera observes X
Direction, another camera observe Y-direction, place a light source in two camera right opposite directions respectively in observation and are conducive to see
It examines.Two cameras can be carried out by rotational structure perpendicular to rotating in horizontal plane, and can also be right by displacement platform
Camera carries out upper and lower and left and right adjusting.
In above scheme, closed container and mini sprinkler are fixed on together in a card slot, and it is same that the card slot passes through connector again
Camera is identical to be fixed on same inverted U bracket, and mini sprinkler is just perpendicular to horizontal plane.And the connector be screwed in
On one displacement platform, upper and lower and left and right movement can be carried out.In the same plane, and Y-direction is taken the photograph for X-direction camera and mini sprinkler
Print state is observed with when in mini sprinkler same plane, being more conducive to printing as head also needs to be adjusted to.Up and down adjustment mini sprinkler
Spray head end can be within the scope of camera Observable, the adjustable camera focusing distance of left and right adjusting mini sprinkler.
In above scheme, the device printed is placed on two dimension or three-dimensional working platform, needs surface face to be printed micro-
Spray head.
In above scheme, the two dimension or three-dimensional working platform are fixed by screws on XY displacement platform, and in workbench
Heart face mini sprinkler.The rotatable platform of three-dimensional working platform is transparent glass, and device surrounding brightness can be improved in transparent glass, more
Phase is taken with high definition added with camera observation is conducive to.Or below two-dimentional work bench install a stroboscopic lamp, adjust drop or
Person makes stroboscopic lamp and mini sprinkler, high definition camera on one wire when printing, convenient for observation drop state, observe by print device
Printout surface situation, and be conducive to high definition capture.
In above scheme, the two dimension or three-dimensional working platform are equipped with a waste liquid tank, and a culture is placed below waste liquid tank
Ware is used to hold the waste liquid generated when adjusting drop, pollutes to prevent other regions to device.
In above scheme, the mini sprinkler control system, controlled by loading voltage signal on mini sprinkler and
Adjust drop state.Control mini sprinkler generates the drop of continuous flow when loading constant voltage；When load pulses signal, pulse letter
Number frequency and time be used to control the interval time between printing drop number, i.e. control print frequency, voltage magnitude size is used to
Control printed droplets size.Meet the requirement of print device by adjusting on-load voltage signal.
In above scheme, the pneumatic control system, using both positive and negative air pressure, micro- ink discharge device is adopted when working normally
It is convenient for the printing of drop with positive air pressure, carries out suck-back with negative pressure when mini sprinkler blocking occurs, mini sprinkler is sucked out in impurity；To micro-
Positive/negative-pressure is alternately used in combination when spray head cleans.
In above scheme, the closed container, the sealing cover for having a rotatable opening and tightening.Printing is packed into containing biochemistry
When molecular fluid, Unscrew sealing cover again tightens sealing cover after installing liquid.Have on the sealing cover connection closed container with
Two conduits of mini sprinkler and pneumatic control system.Wherein sealing cover bottleneck is extended only to pneumatic control system associated conduit
Place, it is another to extend to sealing container bottom with micro- ink-jet print system associated conduit.
In above scheme, the environmental Kuznets Curves and measuring unit, for controlling and detecting institute in biochemical molecular print procedure
The suitable environmental condition needed, the environmental condition includes temperature and humidity.Wherein the regulation of temperature is using heating plate, humidity
Regulation using humidifier carry out.
In above scheme, comprising the following steps:
1) XY displacement platform is initialized, two dimension or three-dimensional working platform center is moved to face mini sprinkler position；
2) the accurate control and measurement for carrying out temperature and humidity to printing environment by environmental Kuznets Curves and measuring unit, reach
It is modified the most suitable condition of biochemical molecular；
3) the biochemical molecular liquid that will be printed is fitted into closed container, makes closed container internal pressure by pneumatic control system
It is much higher than external pressure by force, biochemical molecular is flowed through into mini sprinkler by conduit and forms continuous flow, closing pneumatic control system makes close
It closes that pressure in container is identical as outside pressure, at this time the liquid surface static of mini sprinkler end, and finely tunes to liquid level and mini sprinkler end
In parallel.
4) it adjusts nozzle position observation camera to take in phase it is observed that spray head, then by adjusting camera and spray head distance
It carries out focus adjustment and obtains clearly image.
5) it will be placed in upwards by print device surface on two dimension or three-dimensional working platform, and finely tune camera and spray head obtains
Clear image, will be by print position accurate movement to face spray head, by the way that voltage signal parameter is arranged by control XY displacement platform
Droplet size and drop number are adjusted, printing modification is completed.
6) carry out large scale array formula it is local decorated when, by software program can carry out setting each moving distance with
And each position printing drop number, it fast implements extensive local decorated；
7) it takes out by print device, completes local decorated process.
(3) beneficial effect
It can be seen from the above technical proposal that shown in beneficial effects of the present invention are specific as follows:
1, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, pass through micro- inkjet printing
System realization is local decorated, and relatively large biochemical molecular absorption and non-accurate modification detect for bringing large error, realizes life
Change the highly sensitive of marker, high stable, high-throughput real-time detection.
2, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, part modification is using micro-
Ink jet printing device, biochemical molecular spraying needed for modifying need in modified regions in device, using micro- inkjet printing method into
The modification of row part, may be implemented accurate controlled modification region and dosage, greatly reduce biochemical molecular modification cost.
3, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, part modification is using micro-
Single drop printing and continuously two kinds of operating modes of printing may be selected, to realize micro- to the device of various specifications in ink jet printing device
Amount modification and extensive local decorated.
4, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, micro- ink jet printing device
XY displacement platform being adjusted by observation and being accurately positioned print area, the moving step length of displacement platform can be as needed in control terminal
It is configured on software, modified regions is finally accurately positioned by the adjusting of size step-length.
5, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, printed droplets size can
It is controlled by adjusting the pressure size in air-tight bottle and loading the voltage in mini sprinkler piezoelectric diaphragm, printing drop number and printing
Frequency can be controlled by the frequency of piezoelectric film on piece voltage pulse in mini sprinkler and time.
6, provided by the present invention for the part modification biochemical molecular layer method of micro sensor devices, biochemical molecular was printed
The temperature and humidity environmental condition being suitble to needed for journey can be regulated and controled by heating plate humidifier respectively.To make a living
The entire modification of chemoattractant molecule layer provides good environment.
Detailed description of the invention
To make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
The present invention is described in more detail for attached drawing, in which:
Fig. 1 is that micro- ink-jet system of the part modification biochemical molecular layer method in the present invention for micro sensor devices is whole
Structural schematic diagram；
Fig. 2 is the XY displacement platform and 3-d and 2-d Working table structure schematic diagram of micro- inkjet-printing device in the present invention；
Fig. 3 is the closed container and piezoelectric type mini sprinkler structural schematic diagram of micro- inkjet-printing device in the present invention.
Description of symbols:
1. gas pressure regulator；2.XY displacement platform；3. camera；4. piezoelectric type mini sprinkler and closed container；5.XY displacement platform
Data acquistion and control system and environmental Kuznets Curves and measuring unit；6. two dimension or three-dimensional working platform；7. piezoelectric type mini sprinkler controls
System；8. waste liquid tank；9. stroboscopic lamp；10. closed container；11. piezoelectric type mini sprinkler
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention clearer, below in conjunction with specific embodiment, and reference
Attached drawing, the present invention is described in more detail.
The present invention provides a kind of part modification biochemical molecular layer methods for micro sensor devices, by using having
Piezoelectric type mini sprinkler 4, XY displacement platform 2, two-dimentional or three-dimensional working platform 6 micro- ink jet printing device realize that biochemical molecular layer local is repaired
Decorations.
As shown in Figure 1, Fig. 1 is the part modification biochemical molecular layer for micro sensor devices according to an embodiment of the present invention
The structural schematic diagram of micro- ink jet printing device of method.It specifically includes that piezoelectric type mini sprinkler 4, for printing the life being modified
Chemoattractant molecule；Gas pressure regulator 1, for controlling and closed container air pressure size；Closed container 4 includes by printing for holding
Biochemical molecular solution is connected with gas pressure regulator and piezoelectric type mini sprinkler respectively by conduit, realizes the liquid to piezoelectric type spray head
Face control；Piezoelectric type mini sprinkler control system 7, for regulation and control printed droplets size, drop number and state；Two dimension is three-dimensional
Workbench 6, for placing by print device；XY displacement platform 2, two dimension or three-dimensional working platform are placed in the XY displacement of high precision displacement
On platform, XY displacement platform can be followed to move in the horizontal plane；Two cameras 3, respectively from X and Y-direction three dimensional viewing mini sprinkler and
Device position and drop print situation；XY displacement platform data acquistion and control system and environmental Kuznets Curves and measuring unit 5, XY
Displacement platform data acquistion and control system accurately controls the moving displacement of displacement platform XY all directions by software program and sets
Moving step length is set, environmental Kuznets Curves and measuring unit are used to controlling and detecting the environment being suitble to needed for biochemical molecular print procedure
Condition, the environmental condition include temperature and humidity.
In order to guarantee the high-accuracy property of micro- inkjet-printing device, this is used for the part modification biochemical molecular of micro sensor devices
Micro- ink-jet print system of layer method using as shown in Figure 2 by print device apparatus for placing, will be upward by print device surface
Be placed in two dimension or three-dimensional working platform 6 on, by control XY displacement platform 2 will by print position accurate movement at face spray head,
And finely tune camera 3 and spray head 4 obtains clear image, pass through piezoelectric type mini sprinkler control system 7 and voltage signal and pulse are set
Signal parameter adjusts droplet size, drop number and state, completes printing modification.
As shown in figure 3, Fig. 3 is the closed container and piezoelectric type mini sprinkler structural schematic diagram of micro- inkjet-printing device, wherein
Closed container and mini sprinkler are fixed on together in a card slot, the card slot pass through again connector it is identical with camera be fixed on it is same
On inverted U bracket, mini sprinkler is just perpendicular to horizontal plane.And the connector is screwed on a displacement platform, can be carried out
Lower and left and right movement.The biochemical molecular liquid that will be printed is fitted into closed container, is made by pneumatic control system closed
Pressure is much higher than external pressure in container, and biochemical molecular is flowed through mini sprinkler by conduit and forms continuous flow, closes pressure control
System keeps pressure in closed container identical as outside pressure, at this time the liquid surface static of mini sprinkler end, and finely tune to liquid level with it is micro-
Spray head end is parallel.It adjusts nozzle position to observation camera to take in phase it is observed that spray head, then by adjusting camera and spraying
Head distance carries out focus adjustment and obtains clearly image.
Local modification, accurate controlled modification region and dosage are carried out using the method for micro- inkjet printing, is accurately positioned
Print area is realized local decorated to the high-precision of device.
Particular embodiments described above relatively have in detail to the purpose of the present invention, technical scheme and beneficial effects
The explanation of body is not limited to this hair it should be understood that above-described is only specific embodiments of the present invention
Bright, all any modification, equivalent substitution, improvement and etc. in spirit of the invention, thought and spirit, done should all include
Within protection scope of the present invention.
Claims (11)
1. a kind of part modification biochemical molecular layer method for micro sensor devices, which is characterized in that this method is suitable for each
It plants the device of specification and is suitable for extensive local decorated scheme, comprising:
One piezoelectric type mini sprinkler, for printing the biochemical molecular being modified；
One gas pressure regulator, for controlling and adjusting closed container air pressure size；
One closed container by printing includes biochemical molecular solution for holding, by conduit respectively with gas pressure regulator and pressure
Electric-type mini sprinkler is connected, and realizes the level control to piezoelectric type spray head；
One piezoelectric type mini sprinkler control system, for regulation and control printed droplets size, drop number and state；
One two dimension or three-dimensional working platform, for placing the device printed and the rotation of control device in the original location；
One XY displacement platform, two dimension or three-dimensional working platform are placed on the XY displacement platform of high precision displacement, and XY displacement platform can be followed to exist
It is moved in horizontal plane；
One XY displacement platform data acquistion and control system accurately controls the direction displacement platform XY moving displacement by software program；
Two cameras print situation from X and Y-direction three dimensional viewing mini sprinkler and device position and drop respectively；
One environmental Kuznets Curves and measuring unit, for controlling and detecting the environment item being suitble to needed for biochemical molecular print procedure
Part, the environmental condition include temperature and humidity.
2. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, two cameras are fixed on an inverted U bracket by L-type foot prop, wherein a camera observes X-direction, separately
One camera observes Y-direction, places a light source in two camera right opposite directions respectively in observation and is conducive to observation.Two are taken the photograph
As head can be carried out by rotational structure perpendicular to rotating in horizontal plane, and camera can also be carried out by displacement platform
Upper and lower and left and right adjusting.
3. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, closed container and mini sprinkler are fixed on together in a card slot, and the card slot passes through connector fixation identical with camera again
In on same inverted U bracket, mini sprinkler is just perpendicular to horizontal plane.And the connector is screwed on a displacement platform, it can
Carry out upper and lower and left and right movement.In the same plane, and Y-direction camera also needs to adjust for X-direction camera and mini sprinkler
Print state is observed to when in mini sprinkler same plane, being more conducive to printing.Up and down adjustment mini sprinkler can be by spray head end
Within the scope of camera Observable, the adjustable camera focusing distance of left and right adjusting mini sprinkler.
4. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the device printed is placed on two dimension or three-dimensional working platform, needs surface face mini sprinkler to be printed.
5. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the two dimension or three-dimensional working platform are fixed by screws on XY displacement platform, and table core face mini sprinkler.Three
The rotatable platform for tieing up workbench is transparent glass, and transparent glass can be improved device surrounding brightness, be more conducive to camera
Observation and high definition take phase.Perhaps a stroboscopic lamp is installed below two-dimentional work bench makes stroboscopic when adjusting drop or printing
Lamp and mini sprinkler, high definition camera on one wire, convenient for observation drop state, are observed by the printout surface feelings of print device
Condition, and it is conducive to high definition capture.
6. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is there is a waste liquid tank on the two dimension or three-dimensional working platform, a culture dish is placed below waste liquid tank for holding adjusting
The waste liquid generated when drop pollutes to prevent other regions to device.
7. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the mini sprinkler control system, controls and adjust drop state by loading the voltage signal on mini sprinkler.Add
Control mini sprinkler generates the drop of continuous flow when carrying constant voltage；When load pulses signal, the frequency of pulse signal and time
For controlling the interval time between printing drop number, i.e. control print frequency, voltage magnitude size is used to control printed droplets big
It is small.Meet the requirement of print device by adjusting on-load voltage signal.
8. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the pneumatic control system, using both positive and negative air pressure, liquid is convenient for using positive air pressure when micro- ink discharge device normal print
The printing of drop carries out suck-back with negative pressure when mini sprinkler blocking occurs, impurity is sucked out from mini sprinkler；When to mini sprinkler cleaning
Positive/negative-pressure is alternately used in combination.
9. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the closed container, the sealing cover for having a rotatable opening and tightening.When being packed into printing containing biochemical molecular liquid, rotation
Turn to open sealing cover, again tightens sealing cover after installing liquid.There are connection closed container and mini sprinkler and air pressure on the sealing cover
Two conduits of control system.Sealing cover bottle mouth position, another and micro- spray are wherein extended only to pneumatic control system associated conduit
Black print system associated conduit extends to sealing container bottom.
10. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, the environmental Kuznets Curves and measuring unit, for controlling and detecting the environment being suitble to needed for biochemical molecular print procedure
Condition, the environmental condition include temperature and humidity.Wherein the regulation of temperature is using heating plate, and the regulation of humidity is using humidification
Device carries out.
11. a kind of part modification biochemical molecular layer method for micro sensor devices according to claim 1, feature
It is, comprising the following steps:
1) XY displacement platform is initialized, two dimension or three-dimensional working platform center is moved to face mini sprinkler position；
2) the accurate control and measurement for carrying out temperature and humidity to printing environment by environmental Kuznets Curves and measuring unit, reach and are repaired
Adorn the most suitable condition of biochemical molecular；
3) the biochemical molecular liquid that will be printed is fitted into closed container, keeps pressure in closed container remote by pneumatic control system
Higher than external pressure, biochemical molecular is flowed through into mini sprinkler by conduit and forms continuous flow, closing pneumatic control system makes closed appearance
Pressure is identical as outside pressure in device, at this time the liquid surface static of mini sprinkler end, and finely tunes parallel with mini sprinkler end to liquid level；
4) it adjusts nozzle position observation camera to take in phase it is observed that spray head, then carry out by adjusting camera and spray head distance
Focus adjustment obtains clearly image；
5) it will be placed in upwards by print device surface on two dimension or three-dimensional working platform, and finely tune camera and spray head obtains clearly
Image, will be by print position accurate movement to face spray head, by the way that voltage signal parameter regulation is arranged by control XY displacement platform
Droplet size and drop number, complete printing modification；
6) carry out large scale array formula it is local decorated when, can carry out setting each moving distance and every by software program
A position printing drop number, fast implements extensive local decorated；
7) it takes out by print device, completes local decorated process.
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| CN201910220862.8A Pending CN109822882A (en) | 2019-03-20 | 2019-03-20 | A kind of part modification biochemical molecular layer method for micro sensor devices |
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Citations (6)
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| CN102393410A (en) * | 2011-08-17 | 2012-03-28 | 李迎春 | Two-step modifying technology for sensor |
| CN104723678A (en) * | 2015-03-12 | 2015-06-24 | 上海交通大学 | Electro hydrodynamic preparation device and method for batch micro-droplets and micro-structures |
| CN104758085A (en) * | 2014-12-26 | 2015-07-08 | 南京师范大学 | Three dimensional biology printing device and method |
| CN106891414A (en) * | 2017-01-18 | 2017-06-27 | 西北工业大学 | Droplet ejection printing equipment and the method that Graphene metamaterial microstructure is prepared using the device |
| CN107597461A (en) * | 2017-09-30 | 2018-01-19 | 厦门大学 | A kind of magnetic agitation mini sprinkler and micro-nano direct write platform |
| CN211591312U (en) * | 2019-03-20 | 2020-09-29 | 天津工业大学 | Local modification biochemical molecular layer device for micro sensor |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102393410A (en) * | 2011-08-17 | 2012-03-28 | 李迎春 | Two-step modifying technology for sensor |
| CN104758085A (en) * | 2014-12-26 | 2015-07-08 | 南京师范大学 | Three dimensional biology printing device and method |
| CN104723678A (en) * | 2015-03-12 | 2015-06-24 | 上海交通大学 | Electro hydrodynamic preparation device and method for batch micro-droplets and micro-structures |
| CN106891414A (en) * | 2017-01-18 | 2017-06-27 | 西北工业大学 | Droplet ejection printing equipment and the method that Graphene metamaterial microstructure is prepared using the device |
| CN107597461A (en) * | 2017-09-30 | 2018-01-19 | 厦门大学 | A kind of magnetic agitation mini sprinkler and micro-nano direct write platform |
| CN211591312U (en) * | 2019-03-20 | 2020-09-29 | 天津工业大学 | Local modification biochemical molecular layer device for micro sensor |
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Application publication date: 20190531 |