CN109820872A - It is a kind of to treat dermopathic medical composition and its use - Google Patents
It is a kind of to treat dermopathic medical composition and its use Download PDFInfo
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- CN109820872A CN109820872A CN201910109450.7A CN201910109450A CN109820872A CN 109820872 A CN109820872 A CN 109820872A CN 201910109450 A CN201910109450 A CN 201910109450A CN 109820872 A CN109820872 A CN 109820872A
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- pharmaceutical composition
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- 239000000203 mixture Substances 0.000 title description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 17
- 241001124216 Cicindelinae Species 0.000 claims abstract description 13
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940116229 borneol Drugs 0.000 claims abstract description 12
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940079593 drug Drugs 0.000 claims abstract description 12
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 12
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 12
- 239000011593 sulfur Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 208000014617 hemorrhoid Diseases 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000019441 ethanol Nutrition 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 201000004681 Psoriasis Diseases 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 230000000202 analgesic effect Effects 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 2
- 239000003908 antipruritic agent Substances 0.000 abstract description 2
- 230000001114 myogenic effect Effects 0.000 abstract description 2
- 231100000241 scar Toxicity 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 2
- 208000003251 Pruritus Diseases 0.000 description 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 201000010099 disease Diseases 0.000 description 7
- 208000002474 Tinea Diseases 0.000 description 4
- 241000130764 Tinea Species 0.000 description 4
- 210000000436 anus Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000017520 skin disease Diseases 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000006748 scratching Methods 0.000 description 3
- 230000002393 scratching effect Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 206010017533 Fungal infection Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241001313288 Labia Species 0.000 description 2
- 206010024229 Leprosy Diseases 0.000 description 2
- 241000623906 Lytta vesicatoria Species 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000002640 perineum Anatomy 0.000 description 2
- 210000004706 scrotum Anatomy 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical group CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010068172 Anal pruritus Diseases 0.000 description 1
- 208000016583 Anus disease Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000256113 Culicidae Species 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 206010027304 Menopausal symptoms Diseases 0.000 description 1
- 241000893980 Microsporum canis Species 0.000 description 1
- 241000893976 Nannizzia gypsea Species 0.000 description 1
- 208000031816 Pathologic Dilatation Diseases 0.000 description 1
- 208000009544 Pruritus Ani Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
- 241000223229 Trichophyton rubrum Species 0.000 description 1
- 241000893966 Trichophyton verrucosum Species 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000002255 anal canal Anatomy 0.000 description 1
- 230000002682 anti-psoriatic effect Effects 0.000 description 1
- 229940030999 antipsoriatics Drugs 0.000 description 1
- 210000003363 arteriovenous anastomosis Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000003029 clitoris Anatomy 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 201000007772 internal hemorrhoid Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940055035 trichophyton verrucosum Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention provides dermopathic pharmaceutical composition is treated the present invention provides a kind of, raw material is the component of following parts by weight: 1~3 part of borneol, 1~3 part of tiger beetle, 1~4 part of realgar, 1~4 part of alumen, 0.5~2 part of Sulfur.Effective drug of the present invention is antipruritic, anti-inflammatory analgetic, absorb water fast, myogenic preventing from scar.
Description
Technical field
Dermopathic pharmaceutical composition is treated the present invention relates to a kind of.
Background technique
Skin disease (dermatosis) is the general name occurred in skin and skin accessory organ's disease.Skin is human body maximum
Organ, dermopathic type is not only various, and the disease that a variety of internal organ occur can also have performance on the skin.Cause skin disease
The reason of very much, such as skin disease caused by infective agent, such as leprosy, scabies, nosomycosis, bacterial skin infections usually have one
Fixed infectiousness not only influences health, and raises fear and social discrimination, but with the improvement of people ' s living standards
And scientific and technological progress, the infectious diseases such as leprosy have been obviously controlled in the whole world.Other cause it is dermopathic it is inside and outside because
Element, such as mechanicalness, it is physical, chemically, biological, incretion, immunity, be increasingly valued by people at present.
Summary of the invention
Dermopathic pharmaceutical composition is treated the present invention provides a kind of, raw material is the component of following parts by weight:
1~3 part of borneol, 1~3 part of tiger beetle, 1~4 part of realgar, 1~4 part of alumen, 0.5~2 part of Sulfur.
Further, raw material is the component of following parts by weight:
1.5~2.5 parts of borneol, 1~2 part of tiger beetle, 1~3 part of realgar, 1~3 part of alumen, 0.5~1.5 part of Sulfur.
Further, raw material is the component of following parts by weight:
2 parts of borneol, 1.5 parts of tiger beetle, 2 parts of realgar, 2 parts of alumen, 1 part of Sulfur.
Wherein, described pharmaceutical composition is external drug.
The present invention also provides the preparation methods of aforementioned pharmaceutical compositions, it includes following content: (1) taking raw material;(2) powder
It is broken;(3) it mixes.
The present invention also provides the preparation methods of aforementioned pharmaceutical compositions, it includes following content: (1) taking borneol;(2) it takes
Tiger beetle;(3) realgar is taken;(4) alumen is taken;(5) Sulfur is taken;(6) ethyl alcohol extracts;(7) extracting solution is taken, preparation is prepared.
In the preparation of said extracted liquid, individually each medicine can be extracted, extraction or part medicine can also be mixed
Material uses solvent extraction, and part medicinal material directly beats powder and is used as medicine.
Itch is a kind of dermatological conditions for only having pruitus and damaging without primary cutaneous.The present invention also provides upper
State purposes of the pharmaceutical composition in the drug of preparation treatment pruitus.
Common pruitus has:
(1) pruritus senilis is mainly in the elderly, is often most itched with trunk, mostly because of sebum adenasthenia, dry skin
Etc. caused by factors, female patient may be a kind of performance of postmenopausal syndrome.
(2) pruritus aestivalis is more common in adult, and children can also fall ill.Mostly occur in Qiu Mo and winter temperature change dramatically
When, patient often when undressing before entering warm interior or sleeping, just starts itch.
(3) pruritus aestivalis often causes itch with damp and hot for inducement, and summer sweat, which increases, so that itch is aggravated.
(4) pruritus ani is more common in middle-aged male, and the children for suffering from enterobiasis can also illness.Itch is typically limited to anus
And its surrounding skin, perineum, cysthus and scrotum can be spread to sometimes.It also can be in tongue fur because often scratching is that skin of anus is plump
The secondary lesions such as moss sample becomes or eczema sample becomes.
(5) pruritus scroti itch is mainly limited to scrotum, also can be involved penis, perineum and anus sometimes.Due to continuous
Scratching causes lichenification, the change of eczema sample and secondary infection etc..
(6) vulval pruritus itch often betides large and small labia.Because of constantly scratching, often there are pachyderma and leaching in labia portion
Stain, clitoris and vaginal mucosa can have red and swollen and rotten to the corn.
Dermatophytid infection, also referred to as fungal dermatopathy, refer to by fungus-caused human skin, mucous membrane and hair and
The superficial infection disease of first-class cutaneous appendages.Clinically mostly showed in blister squama type.The common feature of such disease is:
Disease incidence is high, has infectiousness, is easy to recur or infect again.The main pathogenic bacteria of fungal dermatopathy is dermatophyte, including Huang
Tinea bacterium, T.mentagrophytes, Trichophyton rubrum, trichophyton gypseum, Trichophyton verrucosum, Microsporum canis etc..Fungi likes warm moist
Environment, when there is the condition of suitable fungi growth and breeding on human skin, be easy for occur tinea disease.The present invention also provides upper
State purposes of the pharmaceutical composition in the drug of preparation treatment dermatophytid infection.
Hemorrhoid (Hemorrhoids), or claim hemorrhoid, it is a kind of clinically most common disease of anus.According to happening part
Difference, hemorrhoid can be divided into internal piles, external piles and mixed hemorrhoid.It is now recognized that internal piles (Internal hemorrhoid) is anus pad (anal canal
Blood vessel pad) support structure, plexus vasculosus and arteriovenous anastomosis Zhi Fasheng pathology sexually revise or shift.External piles (External
Hemorrhoid) be dentate line distal side veins beneath the skin clump pathological dilatation or thrombosis.Mixed hemorrhoid (Mixed
It hemorrhoid) is internal piles and external piles mixture.The present invention also provides aforementioned pharmaceutical compositions in the medicine for preparing treatment hemorrhoid
Purposes in object.Pharmaceutical composition of the present invention is obvious especially for external piles effect.
Psoriasis is commonly called as psoriasis, is a kind of chronic inflammatory skin, and the course of disease is longer, there is tendency easy to recur, some diseases
Example almost cannot be cured all one's life.The disease is fallen ill based on person between twenty and fifty, is affected to the health and mental status of patient.Clinical table
Now with erythema, based on the scales of skin that peel off, whole body can fall ill, and with scalp, it is relatively conventional that four limbs stretch side, mostly aggravate in winter.
The present invention also provides aforementioned pharmaceutical compositions to prepare the purposes in antipsoriatics object.
Pharmaceutical composition of the present invention, medication only 5 taste, but therapeutic effect is extremely significant, and it is rapid-action, relative to existing skin
Skin medication, drug therapy cost of the present invention is very cheap, and the cost of patient can be effectively reduced.
Specific embodiment
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Pharmaceutical composition drug activity of the present invention:
2 grams of borneol are taken, 1.5 grams of tiger beetle, 2 grams of realgar, 2 grams of alumen, 1 gram of Sulfur, appropriate medicinal alcohol impregnates.When use
Outer wiping is in affected part.
Effect: desinsection is antipruritic, anti-inflammatory analgetic, absorb water fast, myogenic preventing from scar.
The major functions: trick tinea papula, long whelk, whole body length do sore, impetigo, skin hair on the face by trick gas, young men and women
Tinea, men and women's external piles, pudendal pruritus, bite by mosquitos etc..It takes effect immediately after smearing.
In inventor's career in medicine career, above-mentioned patient accepts more than 700 examples for medical treatment altogether, and cure rate reaches 100%, has no Ineffective Cases;
Also, the drug effect is fast, can take an evident turn for the better within ordinary circumstance medication one day, and continuous treatment 3-5 days can fully recover.
Typical case:
Mr. Wang, 37 years old, female, pruritus vulvue have fungal infection.After smearing pharmaceutical composition of the present invention afterwards, alleviate within 1st, 3
It fully recovers within 1.
Liu, male, 76 years old, there were fungal infection in skin many places.After smearing pharmaceutical composition of the present invention afterwards, alleviate within 1st, 3
It fully recovers within 1.
Niu, male suffer from external piles, itch bitterly not only, after smearing pharmaceutical composition of the present invention, fully recover within 3 days.
Embodiment 1
20 grams of borneol are taken, 15 grams of tiger beetle, 20 grams of realgar, 20 grams of alumen, 10 grams of Sulfur, medicinal alcohol is added to impregnate 5~15,
To obtain the final product.
Embodiment 2
Take 2 grams of borneol, 1.5 grams of tiger beetle, 2 grams of realgar, 2 grams of alumen, 1 gram of Sulfur.After crushing, mixes, be prepared into powder.
Embodiment 3
After taking tiger beetle, medicinal alcohol to extract, extracting solution is spare.Other raw materials outside Chinese blister beetle are taken, after crushing, are extracted with Chinese blister beetle
Liquid is added suitable auxiliary material, prepares externally used paste.
Claims (9)
1. a kind of treat dermopathic pharmaceutical composition, it is characterised in that: its raw material is the component of following parts by weight:
1~3 part of borneol, 1~3 part of tiger beetle, 1~4 part of realgar, 1~4 part of alumen, 0.5~2 part of Sulfur.
2. pharmaceutical composition according to claim 1, it is characterised in that: its raw material is the component of following parts by weight:
1.5~2.5 parts of borneol, 1~2 part of tiger beetle, 1~3 part of realgar, 1~3 part of alumen, 0.5~1.5 part of Sulfur.
3. pharmaceutical composition according to claim 2, it is characterised in that: its raw material is the component of following parts by weight:
2 parts of borneol, 1.5 parts of tiger beetle, 2 parts of realgar, 2 parts of alumen, 1 part of Sulfur.
4. pharmaceutical composition according to any one of claims 1 to 3, it is characterised in that: described pharmaceutical composition is outer
Use drug.
5. the preparation method of Claims 1 to 4 any one described pharmaceutical composition, it is characterised in that: it includes following content:
(1) raw material is taken;(2) it crushes;(3) it mixes.
6. the preparation method of Claims 1 to 4 any one described pharmaceutical composition, it is characterised in that: it includes following content:
(1) borneol is taken;(2) tiger beetle is taken;(3) realgar is taken;(4) alumen is taken;(5) Sulfur is taken;(6) ethyl alcohol extracts;(7) extracting solution is taken, is made
Prepare agent.
7. purposes of the Claims 1 to 4 any one described pharmaceutical composition in the drug of preparation treatment pruitus.
8. purposes of the Claims 1 to 4 any one described pharmaceutical composition in the drug of preparation treatment dermatophytid infection.
9. purposes of the Claims 1 to 5 any one described pharmaceutical composition in the drug of preparation treatment psoriasis or hemorrhoid.
Priority Applications (1)
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CN201910109450.7A CN109820872A (en) | 2019-02-11 | 2019-02-11 | It is a kind of to treat dermopathic medical composition and its use |
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CN201910109450.7A CN109820872A (en) | 2019-02-11 | 2019-02-11 | It is a kind of to treat dermopathic medical composition and its use |
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Publication Number | Publication Date |
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Family
ID=66863511
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CN201910109450.7A Pending CN109820872A (en) | 2019-02-11 | 2019-02-11 | It is a kind of to treat dermopathic medical composition and its use |
Country Status (1)
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015568A (en) * | 2007-02-13 | 2007-08-15 | 戴国兴 | Dermatophytosis treating medicine |
CN101120949A (en) * | 2007-07-27 | 2008-02-13 | 王凤山 | Traditional Chinese medicine for treating haemorrhoids |
CN105125983A (en) * | 2015-08-20 | 2015-12-09 | 李秀琴 | External application medicine for treating psoriasis |
CN108635536A (en) * | 2018-07-13 | 2018-10-12 | 魏明辉 | It is a kind of to treat psoriasis liquid medicine |
-
2019
- 2019-02-11 CN CN201910109450.7A patent/CN109820872A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101015568A (en) * | 2007-02-13 | 2007-08-15 | 戴国兴 | Dermatophytosis treating medicine |
CN101120949A (en) * | 2007-07-27 | 2008-02-13 | 王凤山 | Traditional Chinese medicine for treating haemorrhoids |
CN105125983A (en) * | 2015-08-20 | 2015-12-09 | 李秀琴 | External application medicine for treating psoriasis |
CN108635536A (en) * | 2018-07-13 | 2018-10-12 | 魏明辉 | It is a kind of to treat psoriasis liquid medicine |
Non-Patent Citations (8)
Title |
---|
尚佩生: "慢性湿疹及神经性皮炎外用方剂组方用药规律研究", 《中国优秀硕士学位论文全文数据库》 * |
杨叔禹: "《实用国家基本药物手册:基层版》", 31 May 2010, 厦门大学出版社 * |
王英杰等: "中药外治疗法在银屑病中的应用", 《中医药信息》 * |
王静平等: "皮炎宁酊治疗银屑病23例", 《中国疗养医学》 * |
蔡永敏等: "《最新中药药理与临床应用》", 31 January 1999, 华夏出版社 * |
许勉斋: "《勉斋医诀与医话》", 31 May 2018, 中国中医药出版社 * |
邢进等: "《常见皮肤病中医外治妙法经典荟萃》", 31 May 2013, 华中科技大学出版社 * |
郭建生等: "《实用临床中药手册》", 31 August 2016, 郭建生等 * |
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Application publication date: 20190531 |