CN109810428A - A kind of medicinal PVC hard piece and its production technology - Google Patents
A kind of medicinal PVC hard piece and its production technology Download PDFInfo
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Abstract
The invention discloses a kind of medicinal PVC hard piece and its production technology, medicinal PVC hard piece includes following parts by weight: 80-85 parts of PVC;10-15 parts of EVOH;5-7 parts of PE-g-MAH;3-5 parts of plasticizer;2-4 parts of stabilizer;6-8 parts of antistatic agent;0.4-0.8 parts of lubricant.The production technology of medicinal PVC hard piece includes the following steps: that S1 is blended: being first mixed and stirred for uniformly 80-85 parts PVC, 10-15 parts EVOH, 5-7 parts of PE-g-MAH, then pours into extruder, water cooling, pelletizing, drying after squeezing out into strips obtain blended particles;S2 molding: first blended particles, 3-5 parts of plasticizer, 3-4 parts of stabilizers, 6-8 parts of antistatic agents, 0.4-0.8 parts of lubricants, 4-6 parts of antibacterial powders are mixed and stirred for uniformly, extruder is poured into again, squeeze out post-calendering slabbing, thickness control is in 0.15-0.6mm, then cooling and shaping, last deburring, winding.Medicinal PVC hard piece has excellent barrier property, antistatic property, antibiotic property, is suitable for Key works Drug packing.
Description
Technical field
The present invention relates to packaging material, in particular to a kind of medicinal PVC hard piece and its production technology.
Background technique
At present in Key works Drug packing, the solid orally ingestibles product such as pill, capsule, tablet generally uses blister package.Bubble-cap
Packaging material includes medicinal PVC hard piece and medicinal aluminum foil, and PVC stiff sheet is formed multiple by the technique of vacuum suction bubble or compression molding
Cavity is closed for placing the cavity of drug, then through aluminium foil heat seal.In use, finger pokes aluminium foil, it just can be by institute
Drug is needed to take out.
PVC stiff sheet refers to adds certain processing aid as raw material using Corvic again, is added by squeezing out, rolling etc.
What work method was produced meets a kind of packaging material of medicinal requirements, has corrugationless, excellent clarity, thickness uniform, anti-
The advantages that tensile strength is good.
The Chinese patent of Publication No. CN106751205A discloses a kind of medicinal stiff sheet formula of PVC, components by weight are as follows:
Polyvinyl chloride resin: 100kg;Organotin: 1.3-1.5kg;Interior lubrication prescription: 0.4-0.6kg;Outer lubrication prescription: 0.4-0.6kg;ACR:1.2-
1.5kg;MBS:3-9kg;CaSt2:0.14-0.20kg;HSt:0.16-0.20kg;PE-wax:0.03-0.05kg;Chlorine vinegar tree
Rouge: 1.2-3kg;Color masterbatch: 0.018-0.03kg.
Since PVC is insulating materials, sheet resistance is high, therefore is easy in its production process with when roll shaft relative friction
A large amount of electrostatic are formed, are on the one hand easy the presence of production safety, the presence of another aspect electrostatic can adsorb dust, lead to PVC
The decline of stiff sheet quality, and be easy to pollute drug, have much room for improvement.
Summary of the invention
In view of the above technical defects, the object of the present invention is to provide a kind of medicinal PVC hard pieces, have antistatic property, table
Face is not easy to adsorb dust.
To achieve the above object, the present invention provides the following technical scheme that
A kind of medicinal PVC hard piece, including following parts by weight:
80-85 parts of PVC
10-15 parts of EVOH
5-7 parts of PE-g-MAH
3-5 parts of plasticizer
2-4 parts of stabilizer
6-8 parts of antistatic agent
0.4-0.8 parts of lubricant;
The preparation process of the antistatic agent is as follows;By weight, first by 4-7 parts of lauryl amines, 16-20 parts of epoxychloropropane,
160-180 parts of methanol mix and continue to stir 4-5h, add 18-20 parts of 4-methyl hexamethylene diamines, are warming up to 55-60 DEG C, reaction
10-12h, dialysis obtain reaction solution, and finally vacuum drying obtains antistatic agent.
By using above-mentioned technical proposal, PVC has good mechanical performance, but the disadvantages of photo and thermal stability is poor;
EVOH has many advantages, such as that strong high barrier, preferable processing performance, photo and thermal stability, transparency and glossiness are excellent.In PE-g-
With the help of MAH, the compatibility between EVOH and PVC enhances, and the shortcomings that capable of being blended to improve PVC, produces comprehensive performance
Excellent high barrier PVC stiff sheet, so guarantee drug place for a long time after quality.
Antistatic agent molecule forms uniform monolayer after moving to polymer surfaces, and atmosphere is protruded into molecular polarity one end
In, in nonpolar one end insertion polymer, conductive channel is formed, and then reduce the surface resistivity of PVC stiff sheet, release electrostatic;
Antistatic agent molecule has the side-chain structure of pectination, intertwine with each other between molecule, and then reduces the passage of antistatic agent molecule,
Improve the persistence of antistatic property.The cation high molecular of antistatic agent molecule main chain can be adsorbed on bacterium surface simultaneously, break
Bad cell film, and then bactericidal effect is played, avoid the trouble of germ contamination drug.
The present invention is further arranged to: the 4-methyl hexamethylene diamine is TMHDA.
By using above-mentioned technical proposal, relative to TMEDA, the effect of its antistatic agent being prepared is more preferable.
The present invention is further arranged to: further include 4-6 parts of antibacterial powders, the preparation process of the antibacterial powder is as follows:
One, bark of dahurian larch, pinus sylvestris var. mongolica bark, Chinese corktree blade are acquired, natural air drying at shady and cool ventilation is placed in, then at 100-
It is dried at 105 DEG C, then crushes respectively and obtain crushed material, crushed material obtained by bark of dahurian larch is denoted as A powder, pinus sylvestris var. mongolica bark gained
Crushed material is denoted as B powder, and crushed material obtained by Chinese corktree blade is denoted as C powder;
Two, 10-12 parts of A powder are immersed in 90-100 parts of petroleum ethers, heating water bath is to 80-90 DEG C, and flow back 50-60min, then mistake
Filter obtains filtrate, and then filtrate decompression distillation obtains extract A to recycle petroleum ether;
Three, 10-12 parts of B powder are immersed in 90-100 parts of ethyl acetate, heating water bath is to 80-90 DEG C, and flow back 50-60min, then
Filtrate is obtained by filtration, then filtrate decompression distillation obtains extract B to recycle ethyl acetate;
Four, 10-12 parts of C powder are immersed in 90-100 part ethyl alcohol, 3-5h is extracted at 15-20 DEG C, be then obtained by filtration filtrate with
Filter residue, filter residue repeat the above steps, and are repeated 3 times rear mixed filtrate, and filtrate removes ethyl alcohol through vacuum distillation, obtains extract C;
Five, 1:1:2 mixed extract A, extract B, extract C in mass ratio, obtain antibacterial by finally heated to 120-130 DEG C
Powder.
By using above-mentioned technical proposal, bark of dahurian larch, pinus sylvestris var. mongolica bark and the extracted resulting object of Chinese corktree blade
Contain effective antibacterial materials such as saponins, alkaloids, organic acid, Polyphenols in matter, there is synergistic effect between three, be added
It can be improved its antibacterial surface after into PVC stiff sheet.Three kinds of extracts are for remaining tree species simultaneously, with PVC tree
The compatibility of rouge is more preferable.
The present invention is further arranged to: being added to 20g/L tea polyphenols after the extract A, extract B, extract C mixing
In solution, the mass ratio of the tea polyphenols solution and extract A is 3:1.
By using above-mentioned technical proposal, there are complex roles with extract after tea polyphenols are added, so that antibacterial powder is also
It can be improved the barrier properties for gases of PVC stiff sheet.
The present invention is further arranged to: the plasticizer is acetyl tri-n-butyl citrate.
By using above-mentioned technical proposal, on the one hand it is suitable for PVC-EVOH mixture with good plasticization effect
System, on the other hand it is more environmentally friendly.
The present invention is further arranged to: the stabilizer includes cerium stearate, zinc stearate and the season that mass ratio is 2:2:1
Penta tetrol.
By using above-mentioned technical proposal, the disadvantage of PVC photo and thermal stability difference is improved, while the stabilizer is suitable for
PVC-EVOH co-mixing system.
The present invention is further arranged to: the lubricant preparation process is as follows: first by 20-24 parts of oleic acid, 10-12 parts of second two
Alcohol, 0.1-0.2 a part sodium bisulfate monobydrate are mixed and stirred for, and then simultaneously for oil bath heating to 160-170 DEG C, reflux is anti-for lasting stirring
It is cooled to 60-65 DEG C after answering 3-4h, is subsequently added into 20-24 parts of glacial acetic acids and 40-48 parts of hydrogen peroxide, heat preservation reflux, stirring, reaction
It is washed with water after 110-120min, liquid separation, then alkali cleaning 2 times, obtains lubricant.
By using above-mentioned technical proposal, which not only has preferable greasy property, improves the mobility of PVC,
It is environmentally protective, moreover it is possible to improve the transparency of PVC stiff sheet, reduce skin-friction coefficient, and then reduce its surface resistivity.It rises simultaneously
It is vdiverse in function to plasticising, heat-staple effect, the performance of PVC stiff sheet can be improved in all directions.
It is a further object of the present invention to provide a kind of production technologies of medicinal PVC hard piece.
A kind of production technology of medicinal PVC hard piece, includes the following steps:
S1 is blended: being first mixed and stirred for uniformly 80-85 parts PVC, 10-15 parts EVOH, 5-7 parts of PE-g-MAH, then pours into extrusion
Machine, water cooling, pelletizing, drying after squeezing out into strips, obtains blended particles;
S2 molding: first by blended particles, 3-5 parts of plasticizer, 3-4 parts of stabilizers, 6-8 parts of antistatic agents, 0.4-0.8 parts of lubrications
Agent, 4-6 parts of antibacterial powders are mixed and stirred for uniformly, then pour into extruder, squeeze out post-calendering slabbing, thickness control is in 0.15-
0.6mm, then cooling and shaping, last deburring, winding.
In conclusion the invention has the following advantages:
The co-mixing system of 1.PVC, EVOH, PE-g-MAH, so that PVC stiff sheet is relative to market common product with more excellent
Performance, barrier property is high, being capable of effective protection drug;
2. the adaptability of a variety of auxiliary agents such as antistatic agent, plasticizer, stabilizer and co-mixing system is good, easy processing;
3. the addition of antistatic agent can be effectively reduced PVC stiff sheet surface resistivity, enhances antistatic property, avoid Electrostatic Absorption
Dust and the trouble for causing medicine pollution, while the antibiotic property of PVC stiff sheet can also be improved;
4. the addition of antibacterial powder can effectively improve PVC stiff sheet antibiotic rate, avoid the trouble of germ contamination drug.
Detailed description of the invention
Fig. 1 is the flow diagram of embodiment one to three.
Specific embodiment
Below in conjunction with attached drawing, invention is further described in detail.
Embodiment one:
A kind of medicinal PVC hard piece, including following parts by weight:
80 parts of PVC;
It 10 parts of EVOH, model L171B, buys from Kuraray;
It 5 parts of PE-g-MAH, model TY 1052H, buys from Dow;
3 parts of acetyl tri-n-butyl citrate;
2 parts of stabilizer, stabilizer includes cerium stearate, zinc stearate and the pentaerythrite that mass ratio is 2:2:1;
6 parts of antistatic agent;
0.4 part of lubricant;
4 parts of antibacterial powder.
The preparation process of antistatic agent is as follows;By weight, first by 4 parts of lauryl amines, 16 parts of epoxychloropropane, 160 parts
Methanol mixes and continues to stir 4h, adds 18 parts of TMHDA, is warming up to 55 DEG C, reacts 10h, and dialysis obtains reaction solution, last true
Sky is dried to obtain antistatic agent.
The preparation process of antibacterial powder is as follows:
One, bark of dahurian larch, pinus sylvestris var. mongolica bark, Chinese corktree blade are acquired, natural air drying at shady and cool ventilation is placed in, then at 100 DEG C
Lower drying then crushes respectively and obtains crushed material, and crushed material obtained by bark of dahurian larch is denoted as A powder, crushes obtained by pinus sylvestris var. mongolica bark
Object is denoted as B powder, and crushed material obtained by Chinese corktree blade is denoted as C powder;
Two, 10 parts of A powder are immersed in 90 parts of petroleum ethers, heating water bath is to 80 DEG C, and flow back 50min, filtrate is then obtained by filtration, so
Filtrate decompression distillation obtains extract A to recycle petroleum ether afterwards;
Three, 10 parts of B powder are immersed in 90 parts of ethyl acetate, heating water bath is to 80 DEG C, and flow back 50min, filtrate is then obtained by filtration,
Then filtrate decompression distillation obtains extract B to recycle ethyl acetate;
Four, 10 parts of C powder are immersed in 90 parts of ethyl alcohol, 3h is extracted at 15 DEG C, filtrate and filter residue is then obtained by filtration, filter residue repeats
Above-mentioned steps, are repeated 3 times rear mixed filtrate, and filtrate removes ethyl alcohol through vacuum distillation, obtains extract C;
Five, 1:1:2:3 mixed extract A in mass ratio, extract B, extract C, 20g/L tea polyphenols solution, it is finally heated extremely
120 DEG C, obtain antibacterial powder.
Lubricant preparation process is as follows: first mixing 20 parts of oleic acid, 10 parts of ethylene glycol, 0.1 part of sodium bisulfate monobydrate simultaneously
Stirring, then lasting stirring and oil bath heating are cooled to 60 DEG C after back flow reaction 3h, are subsequently added into 20 parts of glacial acetic acids to 160 DEG C
With 40 parts of hydrogen peroxide, heat preservation reflux is stirred, and is washed with water, liquid separation, then alkali cleaning 2 times after reaction 110min, is obtained lubricant.
A kind of production technology of medicinal PVC hard piece, as shown in Figure 1, including the following steps:
S1 is blended: being first mixed and stirred for uniformly, then pours into extruder 80 parts of PVC, 10 parts of EVOH, 5 parts of PE-g-MAH, is extruded into
Water cooling, pelletizing, drying, obtain blended particles after strip;
S2 molding: first by blended particles, 3 parts of acetyl tri-n-butyl citrate, 2 parts of stabilizers, 6 parts of antistatic agents, 0.4 part of lubrication
Agent, 4 parts of antibacterial powders are mixed and stirred for uniformly, then pour into extruder, squeeze out post-calendering slabbing, thickness control in 0.15mm,
Then cooling and shaping, last deburring, winding.
Embodiment two:
A kind of medicinal PVC hard piece, including following parts by weight:
85 parts of PVC;
It 15 parts of EVOH, model L171B, buys from Kuraray;
It 7 parts of PE-g-MAH, model TY 1052H, buys from Dow;
5 parts of acetyl tri-n-butyl citrate;
4 parts of stabilizer, stabilizer includes cerium stearate, zinc stearate and the pentaerythrite that mass ratio is 2:2:1;
8 parts of antistatic agent;
0.8 part of lubricant;
6 parts of antibacterial powder.
The preparation process of antistatic agent is as follows;By weight, first by 7 parts of lauryl amines, 20 parts of epoxychloropropane, 180 parts
Methanol mixes and continues to stir 5h, adds 20 parts of TMHDA, is warming up to 60 DEG C, reacts 12h, and dialysis obtains reaction solution, last true
Sky is dried to obtain antistatic agent.
The preparation process of antibacterial powder is as follows:
One, bark of dahurian larch, pinus sylvestris var. mongolica bark, Chinese corktree blade are acquired, natural air drying at shady and cool ventilation is placed in, then at 105 DEG C
Lower drying then crushes respectively and obtains crushed material, and crushed material obtained by bark of dahurian larch is denoted as A powder, crushes obtained by pinus sylvestris var. mongolica bark
Object is denoted as B powder, and crushed material obtained by Chinese corktree blade is denoted as C powder;
Two, 12 parts of A powder are immersed in 100 parts of petroleum ethers, heating water bath is to 90 DEG C, and flow back 60min, filtrate is then obtained by filtration,
Then filtrate decompression distillation obtains extract A to recycle petroleum ether;
Three, 12 parts of B powder are immersed in 100 parts of ethyl acetate, heating water bath is to 90 DEG C, and flow back 60min, and filter is then obtained by filtration
Liquid, then filtrate decompression distillation obtains extract B to recycle ethyl acetate;
Four, 12 parts of C powder are immersed in 100 parts of ethyl alcohol, 5h is extracted at 20 DEG C, filtrate and filter residue, filter residue weight is then obtained by filtration
Multiple above-mentioned steps, are repeated 3 times rear mixed filtrate, and filtrate removes ethyl alcohol through vacuum distillation, obtains extract C;
Five, 1:1:2:3 mixed extract A in mass ratio, extract B, extract C, 20g/L tea polyphenols solution, it is finally heated extremely
130 DEG C, obtain antibacterial powder.
Lubricant preparation process is as follows: first mixing 24 parts of oleic acid, 12 parts of ethylene glycol, 0.2 part of sodium bisulfate monobydrate simultaneously
Stirring, then lasting stirring and oil bath heating are cooled to 65 DEG C after back flow reaction 4h, are subsequently added into 24 parts of glacial acetic acids to 170 DEG C
With 48 parts of hydrogen peroxide, heat preservation reflux is stirred, and is washed with water, liquid separation, then alkali cleaning 2 times after reaction 120min, is obtained lubricant.
A kind of production technology of medicinal PVC hard piece, as shown in Figure 1, including the following steps:
S1 is blended: being first mixed and stirred for uniformly, then pours into extruder 85 parts of PVC, 15 parts of EVOH, 7 parts of PE-g-MAH, is extruded into
Water cooling, pelletizing, drying, obtain blended particles after strip;
S2 molding: first by blended particles, 5 parts of acetyl tri-n-butyl citrate, 4 parts of stabilizers, 8 parts of antistatic agents, 0.8 part of lubrication
Agent, 6 parts of antibacterial powders are mixed and stirred for uniformly, then pour into extruder, squeeze out post-calendering slabbing, and thickness control connects in 0.6mm
Cooling and shaping, last deburring, winding.
Embodiment three:
A kind of medicinal PVC hard piece, including following parts by weight:
82 parts of PVC;
It 12 parts of EVOH, model L171B, buys from Kuraray;
It 6 parts of PE-g-MAH, model TY 1052H, buys from Dow;
4 parts of acetyl tri-n-butyl citrate;
3 parts of stabilizer, stabilizer includes cerium stearate, zinc stearate and the pentaerythrite that mass ratio is 2:2:1;
7 parts of antistatic agent;
0.6 part of lubricant;
5 parts of antibacterial powder.
The preparation process of antistatic agent is as follows;By weight, first by 6 parts of lauryl amines, 18 parts of epoxychloropropane, 170 parts
Methanol mixes and continues to stir 4.5h, adds 19 parts of TMHDA, is warming up to 58 DEG C, reacts 11h, and dialysis obtains reaction solution, finally
Vacuum drying obtains antistatic agent.
The preparation process of antibacterial powder is as follows:
One, bark of dahurian larch, pinus sylvestris var. mongolica bark, Chinese corktree blade are acquired, natural air drying at shady and cool ventilation is placed in, then at 102 DEG C
Lower drying then crushes respectively and obtains crushed material, and crushed material obtained by bark of dahurian larch is denoted as A powder, crushes obtained by pinus sylvestris var. mongolica bark
Object is denoted as B powder, and crushed material obtained by Chinese corktree blade is denoted as C powder;
Two, 11 parts of A powder are immersed in 95 parts of petroleum ethers, heating water bath is to 85 DEG C, and flow back 55min, filtrate is then obtained by filtration, so
Filtrate decompression distillation obtains extract A to recycle petroleum ether afterwards;
Three, 11 parts of B powder are immersed in 95 parts of ethyl acetate, heating water bath is to 85 DEG C, and flow back 55min, filtrate is then obtained by filtration,
Then filtrate decompression distillation obtains extract B to recycle ethyl acetate;
Four, 11 parts of C powder are immersed in 95 parts of ethyl alcohol, 4h is extracted at 18 DEG C, filtrate and filter residue is then obtained by filtration, filter residue repeats
Above-mentioned steps, are repeated 3 times rear mixed filtrate, and filtrate removes ethyl alcohol through vacuum distillation, obtains extract C;
Five, 1:1:2:3 mixed extract A in mass ratio, extract B, extract C, 20g/L tea polyphenols solution, it is finally heated extremely
125 DEG C, obtain antibacterial powder.
Lubricant preparation process is as follows: first mixing 22 parts of oleic acid, 11 parts of ethylene glycol, 0.15 part of sodium bisulfate monobydrate simultaneously
Stirring, then lasting stirring and oil bath heating are cooled to 62 DEG C after back flow reaction 3.5h, are subsequently added into 22 parts of ice second to 165 DEG C
Sour and 44 parts of hydrogen peroxide, heat preservation reflux are stirred, and are washed with water, liquid separation, then alkali cleaning 2 times after reaction 115min, are obtained lubricant.
A kind of production technology of medicinal PVC hard piece, as shown in Figure 1, including the following steps:
S1 is blended: being first mixed and stirred for uniformly, then pours into extruder 82 parts of PVC, 12 parts of EVOH, 6 parts of PE-g-MAH, is extruded into
Water cooling, pelletizing, drying, obtain blended particles after strip;
S2 molding: first by blended particles, 4 parts of acetyl tri-n-butyl citrate, 3 parts of stabilizers, 7 parts of antistatic agents, 0.6 part of lubrication
Agent, 5 parts of antibacterial powders are mixed and stirred for uniformly, then pour into extruder, squeeze out post-calendering slabbing, and thickness control connects in 0.3mm
Cooling and shaping, last deburring, winding.
Example IV:
Difference with embodiment three is: lubricant is calcium stearate, remaining is all the same.
Embodiment five:
Difference with embodiment three is: plasticizer is dioctyl phthalate, remaining is all the same.
Embodiment six:
Difference with embodiment three is: being added without tea polyphenols solution in antibacterial powder preparation process, remaining is all the same.
Embodiment seven:
Difference with embodiment three is: PVC stiff sheet does not include antibacterial powder, remaining is all the same.
Embodiment eight:
Difference with embodiment three is: 4-methyl hexamethylene diamine TMEDA, remaining is all the same.
Comparative example one:
Difference with embodiment three is: PVC stiff sheet does not include antistatic agent, remaining is all the same.
Comparative example two:
Difference with embodiment three is: antibacterial powder is only made by extract A, remaining is all the same.
Comparative example three:
Difference with embodiment three is: antibacterial powder is only made by extract B, remaining is all the same.
Comparative example four:
Difference with embodiment three is: antibacterial powder is only made by extract C, remaining is all the same.
Comparative example five:
Difference with embodiment three is: PVC stiff sheet does not include EVOH and PE-g-MAH, remaining is all the same.
Comparative example six:
Difference with embodiment three is: PVC stiff sheet does not include EVOH, PE-g-MAH, antistatic agent, antibacterial powder, remaining is
It is identical.
Embodiment one to three meets national drug packaging material standard " YBB00212005-2015 polyvinyl chloride solid medicine
With stiff sheet " requirement.
PVC stiff sheet performance test:
According in national sector standard " GB/T 1038-2000 plastic film and thin slice gas-premeable test method pressure differential method "
The method of record tests the oxygen-barrier property of PVC stiff sheet, obtains oxygen transit dose, is recorded in table 1.
According to national sector standard " GB/T 1410-2006 solid insulating material volume resistivity and surface resistivity test
Method " in record method, PVC stiff sheet is tested, surface resistivity is obtained, is recorded in table 1.
It is recorded according in national sector standard " GB/T 31402-2015 plastics frosting Anti-microbial Performance Tests method "
Method, the anti-microbial property of PVC stiff sheet is tested, strain used be staphylococcus aureus, obtain antibiotic rate, be recorded in
Table 1.
The PVC stiff sheet the performance test results record sheet of 1 embodiment one to eight of table, comparative example one to six
Oxygen transit dose (cm3/m2*24h*0.1MPa) | Surface resistivity (Ω) | Antibiotic rate (%) | |
Embodiment one | 8 | 1.3*109 | 99.6 |
Embodiment two | 9 | 1.4*109 | 99.8 |
Embodiment three | 8 | 1.4*109 | 99.8 |
Example IV | 14 | 7.9*109 | 99.7 |
Embodiment five | 10 | 1.8*109 | 98.4 |
Embodiment six | 13 | 1.5*109 | 95.2 |
Embodiment seven | 13 | 1.3*109 | 51.3 |
Embodiment eight | 9 | 5.5*109 | 99.6 |
Comparative example one | 9 | 5.4*1015 | 66.1 |
Comparative example two | 13 | 1.3*109 | 64.6 |
Comparative example three | 13 | 1.4*109 | 68.1 |
Comparative example four | 13 | 1.3*109 | 71.3 |
Comparative example five | 32 | 1.5*109 | 98.8 |
Comparative example six | 36 | 6.8*1015 | 6.9 |
This specific embodiment is only explanation of the invention, is not limitation of the present invention, and those skilled in the art exist
It can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as in the present invention
Scope of the claims in all by the protection of Patent Law.
Claims (8)
1. a kind of medicinal PVC hard piece, which is characterized in that including following parts by weight:
80-85 parts of PVC
10-15 parts of EVOH
5-7 parts of PE-g-MAH
3-5 parts of plasticizer
2-4 parts of stabilizer
6-8 parts of antistatic agent
0.4-0.8 parts of lubricant;
The preparation process of the antistatic agent is as follows;By weight, first by 4-7 parts of lauryl amines, 16-20 parts of epoxychloropropane,
160-180 parts of methanol mix and continue to stir 4-5h, add 18-20 parts of 4-methyl hexamethylene diamines, are warming up to 55-60 DEG C, reaction
10-12h, dialysis obtain reaction solution, and finally vacuum drying obtains antistatic agent.
2. a kind of medicinal PVC hard piece according to claim 1, it is characterised in that: the 4-methyl hexamethylene diamine is TMHDA.
3. a kind of medicinal PVC hard piece according to claim 1, it is characterised in that: it further include 4-6 parts of antibacterial powders, it is described
The preparation process of antibacterial powder is as follows:
One, bark of dahurian larch, pinus sylvestris var. mongolica bark, Chinese corktree blade are acquired, natural air drying at shady and cool ventilation is placed in, then at 100-
It is dried at 105 DEG C, then crushes respectively and obtain crushed material, crushed material obtained by bark of dahurian larch is denoted as A powder, pinus sylvestris var. mongolica bark gained
Crushed material is denoted as B powder, and crushed material obtained by Chinese corktree blade is denoted as C powder;
Two, 10-12 parts of A powder are immersed in 90-100 parts of petroleum ethers, heating water bath is to 80-90 DEG C, and flow back 50-60min, then mistake
Filter obtains filtrate, and then filtrate decompression distillation obtains extract A to recycle petroleum ether;
Three, 10-12 parts of B powder are immersed in 90-100 parts of ethyl acetate, heating water bath is to 80-90 DEG C, and flow back 50-60min, then
Filtrate is obtained by filtration, then filtrate decompression distillation obtains extract B to recycle ethyl acetate;
Four, 10-12 parts of C powder are immersed in 90-100 part ethyl alcohol, 3-5h is extracted at 15-20 DEG C, be then obtained by filtration filtrate with
Filter residue, filter residue repeat the above steps, and are repeated 3 times rear mixed filtrate, and filtrate removes ethyl alcohol through vacuum distillation, obtains extract C;
Five, 1:1:2 mixed extract A, extract B, extract C in mass ratio, obtain antibacterial by finally heated to 120-130 DEG C
Powder.
4. a kind of medicinal PVC hard piece according to claim 3, it is characterised in that: the extract A, extract B, extraction
It is added in 20g/L tea polyphenols solution after object C mixing, the mass ratio of the tea polyphenols solution and extract A is 3:1.
5. a kind of medicinal PVC hard piece according to claim 1, it is characterised in that: the plasticizer is acetyl tributyl citrate three
N-butyl.
6. a kind of medicinal PVC hard piece according to claim 1, it is characterised in that: the stabilizer includes that mass ratio is 2:
Cerium stearate, zinc stearate and the pentaerythrite of 2:1.
7. a kind of medicinal PVC hard piece according to claim 1, it is characterised in that: the lubricant preparation process is as follows: first
20-24 parts of oleic acid, 10-12 parts of ethylene glycol, 0.1-0.2 parts of sodium bisulfate monobydrates are mixed and stirred for, it is then lasting to stir simultaneously
Oil bath heating is cooled to 60-65 DEG C after back flow reaction 3-4h, is subsequently added into 20-24 parts of glacial acetic acids and 40-48 to 160-170 DEG C
Part hydrogen peroxide, heat preservation reflux are stirred, and are washed with water, liquid separation, then alkali cleaning 2 times after reaction 110-120min, are obtained lubricant.
8. a kind of production technology of medicinal PVC hard piece as claimed in claim 3, which comprises the steps of:
S1 is blended: being first mixed and stirred for uniformly 80-85 parts PVC, 10-15 parts EVOH, 5-7 parts of PE-g-MAH, then pours into extrusion
Machine, water cooling, pelletizing, drying after squeezing out into strips, obtains blended particles;
S2 molding: first by blended particles, 3-5 parts of plasticizer, 3-4 parts of stabilizers, 6-8 parts of antistatic agents, 0.4-0.8 parts of lubrications
Agent, 4-6 parts of antibacterial powders are mixed and stirred for uniformly, then pour into extruder, squeeze out post-calendering slabbing, thickness control is in 0.15-
0.6mm, then cooling and shaping, last deburring, winding.
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