CN1098085C - Medicie for treating gastritis and pathologic affection before gastromucosa cancer - Google Patents
Medicie for treating gastritis and pathologic affection before gastromucosa cancer Download PDFInfo
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- CN1098085C CN1098085C CN 00107280 CN00107280A CN1098085C CN 1098085 C CN1098085 C CN 1098085C CN 00107280 CN00107280 CN 00107280 CN 00107280 A CN00107280 A CN 00107280A CN 1098085 C CN1098085 C CN 1098085C
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Abstract
The present invention relates to medicine for treating gastritis and gastric mucosa precancerous change, which is formed by the preparation that a first formula is prepared from astragalus root, largehead atractylodesrhizome, liquoric root, poria, white paeony root, bupleurum root, rhizoma corydalis, zedoary, officinal magnolia bark and coptis, and lesser galangal rhizome, medcinal evodia fruit, kakuda figwort root, ophiopogon root, Chinese eaglewood and tangerine peel are added in for respectively manufacturing into a second formula, a third formula and a fourth formula by enzyme through conventional methods such as trade purchase, weighing, water solubility extraction, ethanol solubility extraction, etc. The present invention is formed by the preparation of pure natural Chinese herbal medicine, has the advantages of high safety, innocuity and high treating rate, has the characteristics of the whole, the local and time phase in the disease process, is beneficial to treating clinical symptoms, and improves the treating effect on preventing and treating precancerous change.
Description
The present invention relates to a kind of medicine for the treatment of gastritis and gastric mucosa precancerous lesion, relate to specifically a kind ofly execute a kind of Chinese prescription and preparation for the treatment of chronic gastritis and gastric mucosa precancerous lesion thereof that the principle controlled provides, have another name called and be " stomach rehabilitation " according to Chinese medicine is dialectical.
At present, gastropathy is a kind of commonly encountered diseases, the frequently-occurring disease in the clinical medicine, and its common sympton is epigastrium, gastral cavilty portion pain, flatulence, and abdominal distention is felt sick, vomiting, belch, acid regurgitation, heartburn, inappetence, pantothenic acid, bitter taste, poor appetite, weak, anorexia etc. have brought great infringement for people's health.The current domestic traditional Chinese medical science medicine of the controlling gastropathy commonly used Therapeutic Method that adopt a side one medicine more, as " SANJIU WEITAI " formed by three fork hardships, Folium Et Cacumen Murrayae, the Radix Paeoniae Alba, the Radix Rehmanniae, the Radix Aucklandiae etc., as " WEISU CHONGJI " of forming by Caulis Perillae, Pericarpium Citri Reticulatae, Rhizoma Cyperi, Fructus Citri Sarcodactylis etc. etc.But because they all do not have Chinese and western medicine and demonstrate,prove disease combined treatment scope, also think little of the dialectical principle of controlling of executing, thereby the different pattern of syndrome of different phase of different types of chronic gastritis or identical type are difficult to obtain similar satisfactory effect.
The inventor is through for many years experience accumulation and research, genius morbi at chronic gastritis is analyzed, the precancerous lesion (intestinal epithelial metaplasia and atypical hyperplasia) that is chronic gastritis in the clinical medicine and mucosa tissue cell thereof has different traditional Chinese medical science syndrome of spleen-deficiency types in the different phase of disease development.No matter which kind of controls the medicine of stomach, can only be effective to certain stage of certain type of certain gastropathy, can not identical curative effect all be arranged to all stages of all types.And adopt combination of Chinese and Western medicine principle, because of the card prescription, dialectical executing controlled, take into account in the lysis whole, part with the time mutually characteristics, promptly at the different phase of different types of chronic gastritis or identical type, different pattern of syndrome, verification prescription, the medicine of preparation cost invention I number respectively, II number, III number and IV number, to help curing clinical symptoms, improve the curative effect of preventing and treating precancerous lesion.
I medicine of the present invention mainly is to be used for the treatment of the syndrome of deficiency of spleen qi chronic gastritis, is called the stomach rehabilitation I number; II medicine of the present invention, be on the prescription of I medicine with Rhizoma Alpiniae Officinarum and Fructus Evodiae, promptly get and be used to treat the syndrome of deficiency of spleen yang chronic gastritis, be called the stomach rehabilitation II number; III medicine of the present invention is on the I prescription, adds Radix Scrophulariae and Radix Ophiopogonis, promptly gets to be used to treat the syndrome of deficiency of spleen yin chronic gastritis, is called the stomach rehabilitation III number; IV medicine of the present invention is on the I medicament composing prescription, adds Lignum Aquilariae Resinatum and Pericarpium Citri Reticulatae, promptly gets to be used to treat the syndrome of spleen-deficiency and QI-stagnation chronic gastritis, is called the stomach rehabilitation IV number.
Medicine of the present invention, it not only can alleviate and eliminate clinical symptoms, and can reverse the mucosa tissue change, make it normalization, and curative effect is more remarkable, and science is also more arranged.
The object of the present invention is to provide a kind of can be at the different phase of different types of chronic gastritis or identical type, different pattern of syndrome, verification prescription, Pei Zhi a kind of medicine for the treatment of gastritis and gastric mucosa precancerous lesion respectively.
The object of the present invention is achieved like this: it is mainly by the pure Chinese medicinal herbs Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Poria, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Corydalis, Rhizoma Curcumae, Cortex Magnoliae Officinalis, Rhizoma Coptidis is mixed with the I prescription, be mixed with the II prescription with Rhizoma Alpiniae Officinarum and Fructus Evodiae, add and are mixed with Radix Scrophulariae and Radix Ophiopogonis the III prescription, add Lignum Aquilariae Resinatum and Pericarpium Citri Reticulatae and be mixed with the IV prescription, through being purchased, weigh, water solublity extracts, the ethanol dissolubility extracts, make honeyed pill or tablet or capsule or dissolved granule, packing, conventional methods such as check are prepared from, and it is characterized in that it is the I medicine of being made by following weight (g) proportion raw material of the present invention
Radix Astragali 6-30 Rhizoma Atractylodis Macrocephalae 5-25
Radix Glycyrrhizae 2-6 Poria 3-20
Radix Paeoniae Alba 3-15 Radix Bupleuri 4-15
Rhizoma Corydalis 5-15 Rhizoma Curcumae 3-15
Cortex Magnoliae Officinalis 3-15 Rhizoma Coptidis 3-15.
Its feature also is: it is on the basis of I prescription, adds the II medicine of the present invention that following weight (g) proportion raw material is made
Rhizoma Alpiniae Officinarum 2-10g Fructus Evodiae 2-10g.
Its feature also is: it is on the basis of I prescription, adds the III medicine of the present invention that following weight (g) proportion raw material is made
Radix Scrophulariae 2-15g 2-15g Radix Ophiopogonis.
Its feature also is: it is on the basis of I prescription, adds the IV medicine of the present invention that following weight (g) proportion raw material is made
Lignum Aquilariae Resinatum 0.8-3.5g Pericarpium Citri Reticulatae 2-15g.
The present invention compared with prior art, it is at the different phase of different types of chronic gastritis or identical type, different pattern of syndrome, the verification prescription, preparation is prepared from by the pure natural Chinese herbal medicine respectively, and is safe and reliable, have no side effect, and evident in efficacy, the cure rate height, relapse rate is low, and have more science, it take into account in the lysis whole, part with the time mutually characteristics, help to cure clinical symptoms, improve the curative effect of preventing and treating precancerous lesion.
Further specify the present invention below in conjunction with embodiment,
Embodiment 1
1. be purchased and weigh (g) meets the following pure Chinese medicinal herbs of state health standards, meeting processing and preparing under the environment of state health standards,
The Radix Astragali 12 Rhizoma Atractylodis Macrocephalaes 10
Radix Glycyrrhizae 3 Poria 10
The Radix Paeoniae Alba 10 Radix Bupleuri 6
Rhizoma Corydalis 10 Rhizoma Curcumae 6
Cortex Magnoliae Officinalis 6 Rhizoma Coptidis 6.
2. the said herbal medicine material is placed extraction pot, pours into 800 milliliters pure water,
3. after soaking 48 hours at normal temperatures, be fried boiling 1 hour, get filtrate, stay filtering residue, promptly water solublity extracts,
4. the anhydrous alcohol (ethanol) of getting 800 milliliters pours in the extraction pot, soaks again,
5. precipitate with ethanol 48 hours at normal temperatures,
6. being dissolved to content is 75%, gets filtrate, stays filtering residue, and promptly the ethanol dissolubility extracts,
7. water-soluble extracting liquid and ethanol dissolubility extracting solution are concentrated, are dried to powder, and cross 180 mesh sieves,
8. with above-mentioned powder mixing,
9. its powder is poured into softgel shell,
10. packing, after the assay was approved promptly gets a kind of pharmaceutical capsules for the treatment of gastritis and gastric mucosa precancerous lesion of I the present invention, has another name called and is " stomach rehabilitation I number ".
Embodiment 2
1. on the basis of I prescription, be purchased and weigh (g) following pure Chinese medicinal herbs,
Rhizoma Alpiniae Officinarum 6g Fructus Evodiae 6g.
2. processing method is identical with embodiment 1, through water solublity extract, the ethanol dissolubility extracts, be dried to powder, pour into softgel shell, after the packing, check, promptly get capsule shape II medicine of the present invention, have another name called to be " stomach rehabilitation II number ".
Embodiment 3
1. on the basis of I prescription, be purchased and weigh (g) following pure Chinese medicinal herbs,
Radix Scrophulariae 10g 6g Radix Ophiopogonis.
2. processing method is identical with embodiment 1, through water solublity extract, the ethanol dissolubility extracts, be dried to powder, pour into softgel shell, after the packing, check, promptly get the III medicine of the present invention of capsule shape, have another name called to be " stomach rehabilitation III number ".
Embodiment 4
1. on the basis of I prescription, be purchased and weigh (g) following pure Chinese medicinal herbs,
Lignum Aquilariae Resinatum 1.5g Pericarpium Citri Reticulatae 10g.
2. processing method is identical with embodiment 1, through water solublity extract, the ethanol dissolubility extracts, be dried to powder, pour into softgel shell, after the packing, check, promptly get the IV medicine of the present invention of capsule shape, have another name called to be " stomach rehabilitation IV number ".
A kind of medicine for the treatment of gastritis and gastric mucosa precancerous lesion of the present invention is according to the dialectical medicament composing prescription of controlling that principle provided of executing of Chinese medicine; its preparation is through extensive clinical practice in many areas and experimentation; prove its be a kind of efficiently, safely, the medicine that has no side effect; not only can alleviate and eliminate clinical symptoms; and can reverse the mucosa tissue change; make it normalization; treat " SANJIU WEITAI " " WEISU CHONGJI " etc. of the TCM Syndrome Type of multiple chronic gastritis different phase than adopting a side one medicine; curative effect is more remarkable, and the student of section is also more arranged.Case study is as follows:
Example 1
The curative effect of Drug therapy syndrome of spleen-deficiency gastric precancerous lesion of the present invention and to gastric mucosa Zn, Cu, cAMP, SOD, LPO and
3The H-TdRLCT influence
1. purpose: the clinical efficacy and the mechanism of action thereof of observing medicine instant treatment intestinal metaplasia of gastric mucosa (IM) of the present invention and atypical hyperplasia (ATP).
2. method: Chinese and western medicine is demonstrate,proved the disease combination, and dialectical executing controlled, and uses medicine instant of the present invention as treatment group (61 example) with the card plus-minus, will not be dialectical muddyly organizes (54 example) in contrast with WEISU CHONGJI, and other establishes normal healthy controls group (15 example).The treatment before and after all do gastroscopy, get gastric antrum portion mucosa do pathology diagnosis, histochemical stain intestinalization type estranged, gastric mucosa Zn, Cu, cAMP, SOD and Serum LPO,
3H-TdRLCT detects.
3. result:
The symptom curative effect and the pathology curative effect of a, treatment group obviously are better than matched group, P＜0.05-0.001.
Gastric mucosa Zn, Cu before b, treatment group treat, cAMP, SOD and
3H-TdRLCT is all low than the normal healthy controls group; Be improved after the treatment; Then decrease after the Serum LPO treatment, more than changing all has significant difference, P＜0.05-0.001.
4. conclusion: electuary of the present invention reverses IM and ATP, is by improving the level of gastric mucosa Zn, Cu, cAMP and SOD, promote cell differentiation, improve cellular immune function, reduces that the mechanism of oxygen-derived free radicals and LPO realizes.
Example 2
Medicine of the present invention becomes the influence of epithelial nucleus, mitochondrion Zn, Cu and DNA before to syndrome of spleen-deficiency gastric mucosa cancer
1. purpose: observe the influence of electuary of the present invention to gastric epithelial nucleus, mitochondrion Zn, Cu and DNA.
2. method: use electuary of the present invention and treat 61 routine syndrome of spleen-deficiency intestinal metaplasia of gastric mucosa and atypical hyperplasia patients, all do gastroscopy before and after the treatment, get gastric antrum portion mucosa and measure cell and mitochondrial trace element, and mensuration nucleus DNA content.
3. result: 4 groups of syndrome of spleen-deficiency and 4 groups of intestinalization are given birth to hypotypes, and gastric epithelial cell nuclear Zn, Cu and dna level be height than the normal healthy controls group all before treatment, and mitochondrion Zn, Cu level are low than the normal healthy controls group then, P＜0.05-0.01.Improvement is in various degree all arranged, P＜0.05-0.01 after the treatment.
4. conclusion: electuary of the present invention is cured clinical symptoms, reverse IM and ATP, be by improving the level of other biological active substance in gastric epithelial cell nuclear and mitochondrial Zn, Cu, dna content and the body, to safeguard what organismic internal environment adapt mechanism realized.
Example 3
Medicine of the present invention is to the Ultrastructural influence of gastric precancerous lesion syndrome of spleen-deficiency gastric epithelial cell
1. purpose: observe electuary of the present invention to the Ultrastructural influence of gastric epithelial cell.
2. method: use electuary of the present invention and treat 61 routine syndrome of spleen-deficiency intestinal metaplasia of gastric mucosa and atypical hyperplasia patients, all do gastroscopy before and after the treatment, get gastric antrum portion mucosa and adopt transmission electron microscope, observe the epithelial cell ultrastructure.
3. result: 4 groups of syndrome of spleen-deficiency gastric epithelial cell nuclear, mitochondrial ultrastructure after treatment all have improvement in various degree, P＜0.05-0.01, and trend approaches the normal healthy controls group.
4. conclusion: electuary of the present invention is by improving the level of other biological active substance in gastric epithelial cell nuclear and mitochondrial Zn, Cu, dna content and the body; promote epithelial cell differentiation and subcellular fraction ultrastructure normalization; to safeguard organismic internal environment adapt mechanism, reach the effect of curing clinical symptoms, reversing IM and ATP.
Example 4
Medicine of the present invention is to the Ultrastructural influence of gastric precancerous lesion syndrome of spleen-deficiency gastric mucosa
1. purpose: observe electuary of the present invention to the Ultrastructural influence of mucosa tissue.
2. method: use electuary of the present invention and treat 61 routine syndrome of spleen-deficiency intestinal metaplasia of gastric mucosa and atypical hyperplasia patients, all do gastroscopy before and after the treatment, get gastric antrum portion mucosa and make histopathology and adopt scanning electron microscope to make the gastric mucosa Ultrastructural observation.
3. result: 4 groups of syndrome of spleen-deficiency gastric antrum portion focal zone histopathologies, intestinalization are given birth to " background pathological changes " in hypotype and the non-focal zone mucosa ultrastructure, and improvement is all arranged after treatment, P＜0.05-0.01, and trend approaches the normal healthy controls group.
4. conclusion: electuary of the present invention is that the amount between bioactive substance, promotes gastric antrum portion mucosa ultrastructure normalization, and cures clinical symptoms to safeguard organismic internal environment adapt mechanism than equilibrium relation in the body by improving, and reverses IM and ATP.
Up to the present example all obtains satisfied curative effect surplus medicament capsule of the present invention and the extensive clinical practices 3000 in the many areas of electuary warp.
Claims (1)
1. medicine for the treatment of gastritis and gastric mucosa precancerous lesion, it is mainly by the pure Chinese medicinal herbs Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Poria, the Radix Paeoniae Alba, Radix Bupleuri, Rhizoma Corydalis, Rhizoma Curcumae, Cortex Magnoliae Officinalis, Rhizoma Coptidis is mixed with prescription, through being purchased, weigh, water solublity extracts, the ethanol dissolubility extracts, make honeyed pill or tablet or capsule or dissolved granule, packing, conventional methods such as check are prepared from, and it is characterized in that it is the prescription medicine Radix Astragali 6-30 Rhizoma Atractylodis Macrocephalae 5-25 Radix Glycyrrhizae 2-6 Poria 3-20 Radix Paeoniae Alba 3-15 Radix Bupleuri 4-15 Rhizoma Corydalis 5-15 Rhizoma Curcumae 3-15 Cortex Magnoliae Officinalis 3-15 Rhizoma Coptidis 3-15 of the present invention that is made by following weight (g) proportion raw material.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107280 CN1098085C (en) | 2000-05-08 | 2000-05-08 | Medicie for treating gastritis and pathologic affection before gastromucosa cancer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107280 CN1098085C (en) | 2000-05-08 | 2000-05-08 | Medicie for treating gastritis and pathologic affection before gastromucosa cancer |
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| Publication Number | Publication Date |
|---|---|
| CN1273831A CN1273831A (en) | 2000-11-22 |
| CN1098085C true CN1098085C (en) | 2003-01-08 |
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| CN 00107280 Expired - Fee Related CN1098085C (en) | 2000-05-08 | 2000-05-08 | Medicie for treating gastritis and pathologic affection before gastromucosa cancer |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100364594C (en) * | 2006-02-28 | 2008-01-30 | 孟宪安 | Medicine for treating chronic superficial gastritis and peptic ulcer diseases |
| CN101966262B (en) * | 2010-10-14 | 2011-09-14 | 史元生 | Oral traditional Chinese medicine for treating chronic gastritis |
| CN103446347B (en) * | 2013-01-14 | 2015-03-11 | 陈树杰 | Medical aquilaria sinensis moxibustion stick for treating chronic gastric disease |
| CN104043095B (en) * | 2014-07-09 | 2017-01-11 | 王艳波 | Traditional Chinese medicine granules for treating superficial gastritis and reflux esophagitis and preparation method thereof |
| CN105597024A (en) * | 2016-03-02 | 2016-05-25 | 芜湖禧来旺农业有限公司 | Traditional Chinese medicine for treating chronic gastritis |
| CN106963932B (en) * | 2017-03-28 | 2020-05-05 | 申艳慧 | Traditional Chinese medicine composition for invigorating spleen and recovering stomach and preparation method and application thereof |
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