CN1098076C - Oral linmerjing as one kind of powerful anti-bacterial medicine - Google Patents
Oral linmerjing as one kind of powerful anti-bacterial medicine Download PDFInfo
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- CN1098076C CN1098076C CN99115030A CN99115030A CN1098076C CN 1098076 C CN1098076 C CN 1098076C CN 99115030 A CN99115030 A CN 99115030A CN 99115030 A CN99115030 A CN 99115030A CN 1098076 C CN1098076 C CN 1098076C
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- former powder
- gonorrhea
- syphilis
- erythromycin
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Abstract
The present invention relates to a powerful anti-bacterium medicine, namely oral 'Linjunjing', which is prepared from one of erythromycin, tetracycline and gentamicin, prednisone, nitrofurantoin, chlorpheniramine, trimethoprim, dexamethasone and vitamin B2 initial powder according to a certain proportion; the preparation can be capsules or tablets. The 'Linjunjing' has the characteristics of broad-spectrum antibacterium, wide application range, little side or toxic effect, low price, significant curative effect, etc. The 'Linjunjing' can be rapidly absorbed through oral administration and quickly reaches the maximum concentration in blood (about 11 times higher than that of the erythromycin and the penicillin of equal quantity), and the effectively curative concentration can reach more than 12 hours. The present invention particularly has obvious effect on syphilis and gonorrhea.
Description
The present invention relates to a kind of antibiotic medicine, particularly a kind of broad-spectrum antifungal oral drug.It is applicable to that it is inflammation diseases such as infection, skin soft-tissue infection, the infection of oral cavity portion that infection, Genito-urinary are exhaled in treatment, is particularly suitable for treating syphilis and gonorrhea.
Existing antibiotics (antibiotic) oral drugs mainly contain erythromycin, penicillin (aromoline), tetracycline, cephalosporin etc.Though its erythromycin, penicillin treatment inflammation good effect, price is higher, toxic and side effects big (needing when taking can reduce toxic and side effects with the other medicines compatibility), the intestines and stomach patient is reached this drug allergy person is avoided usefulness.
Though China treats multiple antiinflammatory, antibacterials such as the existing unusual mycin of the medicine of syphilis and gonorrhea, trobicin, Pinocine, pouring prunus mume (sieb.) sieb.et zucc. one day are clear at present, can only treat general gonorrhea, and be to control table, can not control root; To treating almost inefficacy of syphilis and gonorrhea severe patient.
Purpose of the present invention is intended to overcome the deficiency of above-mentioned antibiotic medicine, the inventor successfully develops a kind of broad-spectrum antifungal oral drug (it is mould clean that this medicine also claims the peace dimension to drench) for the treatment of skin soft-tissue infection and syphilis gonorrhea through concentrating on studies and clinical practice for many years.
Technical scheme of the present invention is to realize like this: medicine by a kind of and prednisone in erythromycin, tetracycline, the gentamycin, nitrofurantoin, Piao Ermin, trimethoprim (TMP), dexamethasone, vitamin B2 totally seven kinds of pharmaceutical compositions form.
Described seven kinds of amount of drug proportionings (meter by weight): the former powder 10-15 of erythromycin part, the former powder 0.8-1.2 of prednisone part, the former powder 8-12 of nitrofurantoin part, the quick former powder 0.2-0.6 part of Piao Er, the former powder 8-12 of trimethoprim (TMP) part, the former powder 12-18 of dexamethasone part, the former powder 1-2 of vitamin B2 part.
Described seven kinds of amount of drug proportionings: the former powder 20-30 of tetracycline part, the deal of the former powder of prednisone, the former powder of nitrofurantoin, the quick former powder of Piao Er, the former powder of trimethoprim (TMP), the former powder of dexamethasone, the former powder of vitamin B2 is the same.
Described seven kinds of amount of drug proportionings: the former powder 4-8 of gentamycin part, the deal of the former powder of prednisone, the former powder of nitrofurantoin, the quick former powder of Piao Er, the former powder of trimethoprim (TMP), the former powder of dexamethasone, the former powder of vitamin B2 is still the same.
The dosage form of medicine is capsule or tablet (its manufacture method is prior art).
The present invention has broad-spectrum antiseptic (seeing Table), the scope of application wide (seeing Table two), oral absorption is fast, toxic and side effects is little, price low (lower by 1/2 than penicillin price, than trobicin, Pinocine, mould one day clear price low about 1/10 of pouring), curative effect advantages of higher.This product oral absorption is fast, and rises in blood rapidly and reach maximum concentration (erythromycin than equivalent is high 10 times approximately, penicillin is high 10 times, tetracycline high 15 times), and it is effectively treated concentration and can reach more than 12 hours.Medicine of the present invention is through in recent years thousands of routine clinical practice: respiratory tract infection cure rate 75%, Genito-urinary system infect cure rate 85%, skin soft-tissue infection cure rate 90%, oral cavity portion and infect cure rate and reach 56%, and especially syphilis and gonorrhea cure rate are up to (see Appendix: this medicine healing medical record is waited to mend) 95% or more.
The present invention is a kind of specially good effect antibiotic medicine, has detoxifcation and suppurates, and staphylococcus, copper ball bacterium, gonorrhea change coccus, treponema pallidum are all had specially good effect.The present invention is also effective in cure to treatment lymphadenitis, mastitis, inflammatory eye, osteomyelitis, meningitis, otitis media etc.
Below in conjunction with embodiment the present invention is described in further detail:
Embodiment one: drug dose proportioning (meter by weight): 12.5 parts in the former powder of erythromycin, 1 part in the former powder of prednisone, 10 parts in the former powder of nitrofurantoin, 0.4 part in the quick former powder of Piao Er, 10 parts in the former powder of trimethoprim (TMP), 15 parts in the former powder of dexamethasone, 1.5 parts in the former powder of vitamin B2.
The medicine manufacture method: with join former medicated powder fully mix mix all after, make capsule formulation (the medicated powder amount in each capsules is heavily by 504mg) in incapsulating, the capsule that installs medicated powder is dressed up 12 of every plates with packing, and with the golden yellow sealing capsule face (manufacture method of capsule formulation medicine is a known technology) of nontoxic ebonite.Contain the former powder 125mg of erythromycin (0.125 ten thousand unit), the former powder 10mg of prednisone, the quick former powder 4mg of the former powder 100mg of nitrofurantoin, Piao Er, the former powder 100mg of trimethoprim (TMP), the former powder 150mg of dexamethasone, the former powder 15mg of vitamin B2 in each capsules.This property of drug: yellow crystalline powder, odorless, flavor are extremely bitter; Water-soluble, be insoluble to ether.Hygroscopicity is arranged, meet photochromic gradual change, keep in Dark Place.Avoid and the Metal Contact except that rustless steel and aluminum.The name of this medicine is called " the peace dimension is drenched mould clean capsule ".
Embodiment two: drug dose proportioning (meter by weight): 25 parts in the former powder of tetracycline, 10 parts in the former powder of 1 part of nitrofurantoin of the former powder of prednisone, 0.4 part in the quick former powder of Piao Er, 10 parts in the former powder of trimethoprim (TMP), 15 parts in the former powder of dexamethasone, 1.5 parts in the former powder of vitamin B2.
Medicine manufacture method and property of drug are with embodiment one.Medicated powder amount in each capsules wherein contains the former powder 250mg of tetracycline, the former powder 10mg of prednisone, the quick former powder 4mg of the former powder 100mg of nitrofurantoin, Piao Er, the former powder 100mg of trimethoprim (TMP), the former powder 150mg of dexamethasone, the former powder 15mg of vitamin B2 heavily by 629mg.
Embodiment three: medicine dosage (meter) by weight: gentamycin is 6 parts, 1 part in the former powder of prednisone, 10 parts in the former powder of nitrofurantoin, 0.4 part in the quick former powder of Piao Er, 10 parts in the former powder of trimethoprim (TMP), 15 parts in the former powder of dexamethasone, 1.5 parts in the former powder of vitamin B2.
Medicine manufacture method and property of drug are with embodiment one.Medicated powder amount in each capsules wherein contains the former powder 60mg of gentamycin (60,000 unit), the former powder 10mg of prednisone, the quick former powder 4mg of the former powder 100mg of nitrofurantoin, Piao Er, the former powder 100mg of trimethoprim (TMP), the former powder 150mg of dexamethasone, the former powder 15mg of vitamin B2 heavily by 409mg.
Embodiment four: the drug dose proportioning: 10 parts in the former powder of erythromycin (or 23 parts of tetracyclines or gentamycin 5 parts), 0.8 part in the former powder of prednisone, 8 parts in the former powder of nitrofurantoin, 0.3 part in the quick former powder of Piao Er, 8 parts in the former powder of trimethoprim (TMP), 12 parts in the former powder of dexamethasone, 1 part in the former powder of vitamin B2.Medicine manufacture method and property of drug are with embodiment one.Each medicated powder content in each capsules is about above-mentioned.
Embodiment five: the drug dose proportioning: 15 parts in the former powder of erythromycin (or 28 parts in the former powder of tetracycline, or the former powder of gentamycin 8 parts), 1.2 parts in the former powder of prednisone, 12 parts in the former powder of nitrofurantoin, 0.5 part in the quick former powder of Piao Er, 11 parts in the former powder of trimethoprim (TMP), 17 parts in the former powder of dexamethasone, 1.8 parts in the former powder of vitamin B2.Medicine manufacture method and property of drug are with embodiment one.
Medicine of the present invention can contain sugar coated tablet through being processed into by the medicine dosage of the foregoing description.The manufacture method of this tablet also is a known technology.
The usual amounts of this medicine: be grown up each two every day three times, disintegrate in oral back a minute absorbs completely rapidly, antibiotic complete, and extensively branch is in body fluid and each tissue.Blood Chinese medicine pastille height, long half time, high-efficiency continuous reaching more than 12 hours.Stable in gastric acid, taking convenience, safety.In medicine entered the pathogenic bacteria cyton, it was synthetic to restrain bacterioprotein, eliminating bacteria, and curative effect is higher than erythromycin, penicillin 1-10 times.
The broad-spectrum antiseptic scope of table one medicine of the present invention
The clinical indication of table two medicine of the present invention
| Gram-positive bacterium | Gramnegative bacterium |
| Propionibacterium Bacillus acidi lactici anaerobic bacteria peptococcus Eubacterium clostridium tetani pneumococcus rib shape bacillus | Bloodthirsty Bacillus influenzae is caution Salmonella Bordetella pertussis diplococcus spiral shell family body escherichia coli meningitis diplococcus how |
| Genealogical classification | Indication |
| Respiratory tract | The flu scabies secondary infection, bronchitis, pneumonia etc. |
| Alimentary canal | Gall-bladder and infection of biliary tract, acute gastritis, bacillary dysentery, typhoid fever and paratyphoid |
| The urinary tract | Gonorrhoea infection and non-gonorrhoea sexuality are dyed urethritis etc. |
| Skin, soft tissue | Cellulitis, skin, the intestines infection etc. of bursting. |
| Other | Adnexitis, syphilis, eczema, urethra have an intense pain, itch, Erosive purulence skin, squama disease scabies, neurodermatitis etc. Special Other substitute to the penicillin anaphylaxis patient. |
Claims (7)
1, a kind of broad-spectrum antifungal oral drug for the treatment of skin soft-tissue infection and syphilis gonorrhea, it is characterized in that: medicine is by erythromycin, tetracycline, a kind of and prednisone in the gentamycin, nitrofurantoin, Piao Ermin, trimethoprim (TMP), dexamethasone, totally seven kinds of pharmaceutical compositions of vitamin B2 is formed, the proportioning of medicine (meter by weight): the former powder 10-15 of erythromycin part, the former powder 0.8-1.2 of prednisone part, the former powder 8-12 of nitrofurantoin part, the quick former powder 0.2-0.6 part of Piao Er, the former powder 8-12 of trimethoprim (TMP) part, the former powder 12-18 of dexamethasone part, the former powder 1-2 of vitamin B2 part.
2, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 1 and syphilis gonorrhea is characterized in that: the former powder 20-30 of tetracycline part.
3, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 1 and syphilis gonorrhea is characterized in that: the former powder 4-8 of gentamycin part.
4, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 1 and syphilis gonorrhea, it is characterized in that: pharmaceutical formulation is a capsule, and each capsules contains the former powder 125mg of erythromycin, the former powder 10mg of prednisone, the quick former powder 4mg of the former powder 100mg of nitrofurantoin, Piao Er, the former powder 100mg of trimethoprim (TMP), the former powder 150mg of dexamethasone, the former powder 15mg of vitamin B2.
5, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 4 and syphilis gonorrhea is characterized in that: the contained former powder of erythromycin of each capsules is the former powder 250mg of tetracycline, and other medicines content is constant.
6, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 4 and syphilis gonorrhea is characterized in that: the contained former powder of erythromycin of each capsules is the former powder 60mg of gentamycin, and other medicines content is constant.
7, the broad-spectrum antifungal oral drug of treatment skin soft-tissue infection according to claim 1 and syphilis gonorrhea is characterized in that: pharmaceutical formulation is a sugar coated tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115030A CN1098076C (en) | 1999-07-22 | 1999-07-22 | Oral linmerjing as one kind of powerful anti-bacterial medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99115030A CN1098076C (en) | 1999-07-22 | 1999-07-22 | Oral linmerjing as one kind of powerful anti-bacterial medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1241405A CN1241405A (en) | 2000-01-19 |
| CN1098076C true CN1098076C (en) | 2003-01-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99115030A Expired - Fee Related CN1098076C (en) | 1999-07-22 | 1999-07-22 | Oral linmerjing as one kind of powerful anti-bacterial medicine |
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| Country | Link |
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| CN (1) | CN1098076C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110124041B (en) * | 2019-05-14 | 2021-10-15 | 青岛大学附属医院 | Pharmaceutical composition capable of resisting retention bacteria and biofilm bacteria and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077131A (en) * | 1993-04-03 | 1993-10-13 | 刘振宪 | The once clear and manufacture method of syphilis, gonorrhea |
| CN1194858A (en) * | 1998-04-17 | 1998-10-07 | 边靖 | Stasis-freeing and toxin-resolving medicine and producing method thereof |
-
1999
- 1999-07-22 CN CN99115030A patent/CN1098076C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077131A (en) * | 1993-04-03 | 1993-10-13 | 刘振宪 | The once clear and manufacture method of syphilis, gonorrhea |
| CN1194858A (en) * | 1998-04-17 | 1998-10-07 | 边靖 | Stasis-freeing and toxin-resolving medicine and producing method thereof |
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| Publication number | Publication date |
|---|---|
| CN1241405A (en) | 2000-01-19 |
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