CN109806921B - Preparation method of cloth chip and cloth chip - Google Patents
Preparation method of cloth chip and cloth chip Download PDFInfo
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- CN109806921B CN109806921B CN201910167175.4A CN201910167175A CN109806921B CN 109806921 B CN109806921 B CN 109806921B CN 201910167175 A CN201910167175 A CN 201910167175A CN 109806921 B CN109806921 B CN 109806921B
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- 239000004744 fabric Substances 0.000 title claims abstract description 168
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000758 substrate Substances 0.000 claims abstract description 65
- 239000003607 modifier Substances 0.000 claims abstract description 32
- 239000011248 coating agent Substances 0.000 claims abstract description 11
- 238000000576 coating method Methods 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000004140 cleaning Methods 0.000 claims abstract description 4
- 229920002379 silicone rubber Polymers 0.000 claims description 22
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 230000005294 ferromagnetic effect Effects 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 239000004819 Drying adhesive Substances 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 239000004945 silicone rubber Substances 0.000 claims description 4
- 239000002383 tung oil Substances 0.000 claims description 4
- 238000010147 laser engraving Methods 0.000 claims description 3
- 230000005389 magnetism Effects 0.000 claims description 3
- 239000000565 sealant Substances 0.000 claims description 3
- 239000003566 sealing material Substances 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 claims description 2
- -1 polydimethylsiloxane Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 12
- 238000002474 experimental method Methods 0.000 abstract description 8
- 238000001514 detection method Methods 0.000 abstract description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 30
- 229910052742 iron Inorganic materials 0.000 description 16
- 238000005516 engineering process Methods 0.000 description 10
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 4
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 description 3
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 3
- 238000007598 dipping method Methods 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 238000002032 lab-on-a-chip Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 2
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- 238000002798 spectrophotometry method Methods 0.000 description 2
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- 235000011293 Brassica napus Nutrition 0.000 description 1
- 240000008100 Brassica rapa Species 0.000 description 1
- 235000000540 Brassica rapa subsp rapa Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 229940064302 folacin Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000007641 inkjet printing Methods 0.000 description 1
- 150000002505 iron Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 238000004804 winding Methods 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a preparation method of a cloth chip, which comprises the steps of selecting cloth with a proper size, cleaning and airing the cloth to be used as a cloth chip substrate; selecting a mask and a base according to the type of the cloth chip, placing the cloth chip base on the base, and fixedly placing the mask on the cloth chip base; preparing a modifier, and uniformly coating the modifier on the surface of the cloth chip substrate; and after the modifier is solidified, removing the mask to obtain the cloth chip. The method is simple and easy to implement, and can be used for conveniently preparing the cloth chip. The invention also provides a cloth chip which can be folded for multiple times, so that the cloth chip can be conveniently switched between a three-dimensional state and a one-dimensional state, multiple experiments can be carried out in the three-dimensional state, the one-dimensional state is convenient for observation and detection, and in addition, the cloth chip can be cleaned by clear water after the experiments are finished and can be reused subsequently.
Description
Technical Field
The invention relates to the technical field of microfluidic chips, in particular to a preparation method of a cloth chip and the cloth chip.
Background
The microfluidic chip technology is a technology for performing biochemical analysis or medical diagnosis by controlling a trace amount of liquid sample or detection agent by using a micron or submicron channel. Also known as Lab on a Chip (LOC), is one of the most representative micro-integration technologies in the world.
In the existing microfluidic chip technology, paper is used as a substrate to construct a paper chip as a detection platform, and the method has many advantages, such as environmental friendliness, easiness in processing and the like. Martinez and the like manufacture a multi-channel paper-based micro-fluidic chip capable of detecting glucose and protein, and arouse a new round of research enthusiasm of paper chips, and the development of the paper chips is different day by day, particularly in the aspect of preparation technology, and the technical means are quite abundant: wax patterning technology, ink jet printing technology, flexible printing technology, paper-cut-and-folded technology and the like are in a wide range.
However, the inventor finds that the paper chip in the prior art has certain disadvantages, such as complicated preparation process, time and labor consumption, and in addition, the paper chip can only be used once and cannot be reused, thereby causing poor economical and practical performance of the paper chip.
Disclosure of Invention
According to the defects of the prior art, the invention provides the preparation method of the cloth chip and the cloth chip, the preparation method is simple, the cloth chip can be repeatedly used, and the cloth chip has high economical practicability.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
as a first aspect of the present invention, there is provided a method for preparing a cloth chip comprising
Selecting cloth with proper size, cleaning and airing to serve as a cloth chip substrate;
selecting a mask and a base according to the type of the cloth chip, placing the cloth chip base on the base, and fixedly placing the mask on the cloth chip base;
preparing a modifier, and uniformly coating the modifier on the surface of the cloth chip substrate;
and after the modifier is solidified, removing the mask to obtain the cloth chip.
In an alternative embodiment of the present invention, when the type of the cloth chip is a dot matrix type, the magnet block is selected as a mask, the flat plate made of a ferromagnetic material is selected as a base, and the mask and the cloth chip substrate are mounted in such a manner that
And the cloth chip substrate is flatly laid on the base, and the mask is fixedly placed on the cloth chip substrate by utilizing the magnetism between the magnet block and the ferromagnetic substance.
In an alternative embodiment of the present invention, after the modifier is uniformly applied to the surface of the cloth chip substrate, the base is inclined so that the excess modifier on the cloth chip substrate naturally flows down.
As an alternative embodiment of the present invention, when the cloth chip is of a pipe type, a binding tape made of a sealing material is selected as a mask, a cylindrical body is selected as a base, and the mask and the cloth chip substrate are mounted in such a manner that
And paving the cloth chip substrate along the side wall of the base, and binding and fixing the cloth chip substrate by using a mask.
As an alternative embodiment of the present invention, when the cloth chip is of star type, a mask is obtained by engraving a sheet-like body having poor water absorbability in accordance with a predetermined pattern using a laser engraving machine, a flat plate is selected as a base, and the mask and the cloth chip substrate are mounted in such a manner that
And flatly paving the cloth chip substrate on the base, and then attaching the mask to the surface of the cloth chip substrate.
In an alternative embodiment of the present invention, after the modifier is uniformly applied to the surface of the cloth chip substrate, the base is inclined so that the excess modifier on the cloth chip substrate naturally flows down, or
And hanging the cloth chip substrate to enable the redundant modifier on the cloth chip substrate to naturally flow down.
As an optional embodiment of the invention, after the modifier is uniformly coated on the surface of the cloth chip substrate, the cloth chip substrate is placed still for 30 to 60 minutes and then placed in an oven to be heated at 50 to 80 ℃ to promote the curing of the silicon rubber.
As an optional embodiment of the present invention, the modifier is any one of silicone rubber, polydimethylsiloxane, SE901 electronic potting adhesive, quick-drying adhesive, tung oil, and waterproof adhesive.
As a second aspect of the present invention, there is provided a cloth chip prepared by the above-described method for preparing a cloth chip.
The invention has the beneficial effects that:
the invention provides a preparation method of a cloth chip, which is simple and feasible and can be used for conveniently preparing the cloth chip. The invention also provides a cloth chip which can be folded for multiple times, so that the cloth chip can be conveniently switched between a three-dimensional state and a one-dimensional state, multiple experiments can be carried out in the three-dimensional state, the one-dimensional state is convenient for observation and detection, and in addition, the cloth chip can be cleaned by clear water after the experiments are finished and can be reused subsequently.
Drawings
The invention is further illustrated with reference to the following figures and examples.
FIG. 1 is a logical block diagram of a first aspect of the present invention;
FIG. 2 is a schematic view of example 1 of the present invention;
FIG. 3 is a schematic view of example 2 of the present invention;
FIG. 4 is a schematic view of example 3 of the present invention;
FIG. 5 is a graph showing the results of the experiment in example 4 of the present invention.
In the figure, 1-magnet block, 2-cloth chip substrate, 3-iron box, 4-cylinder, 5-iron wire, 6-sheet body.
Detailed Description
The following embodiments are provided to describe the embodiments of the present invention, and to further describe the detailed description of the embodiments of the present invention, such as the shapes, configurations, mutual positions and connection relationships of the components, the functions and operation principles of the components, the manufacturing processes and operation methods, etc., so as to help those skilled in the art to more fully, accurately and deeply understand the inventive concept and technical solutions of the present invention.
As a first aspect of the present invention, as shown in FIG. 1, there is provided a method of manufacturing a cloth chip comprising
S1, selecting cloth with proper size, cleaning and airing the cloth to be used as a cloth chip substrate;
step S2, selecting a mask and a base according to the type of the cloth chip, placing the cloth chip base on the base, and fixedly placing the mask on the cloth chip base;
step S3, preparing a modifier, and uniformly coating the modifier on the surface of the cloth chip substrate;
and step S4, after the modifier is solidified, removing the mask to obtain the cloth chip.
The invention provides a preparation method of a cloth chip, which is simple and feasible and can be used for conveniently preparing the cloth chip.
In some optional embodiments, the invention provides a preparation method of a cloth chip, which comprises the following specific steps:
example 1
When the type of the cloth chip is a dot matrix type, in step S2, the magnet block 1 is selected as a mask, and a flat plate made of a ferromagnetic substance is selected as a base, and the mask and the cloth chip substrate 2 are mounted in such a manner that the cloth chip substrate 2 is laid flat on the base, and the mask is fixed on the cloth chip substrate 2 by using magnetism between the magnet block 1 and the ferromagnetic substance. After the modifier is uniformly applied on the surface of the die substrate 2 in step S3, the base is inclined so that the excess modifier on the die substrate 2 naturally flows down. And uniformly coating the modifier on the surface of the cloth chip substrate 2, standing for 30-60 minutes, and heating in an oven at 50-80 ℃ to promote the curing of the silicon rubber.
Specifically, as shown in fig. 2, for a simple lattice type microchip, the type of the cloth chip is lattice type, a white cloth piece with a proper size is taken and washed and dried to be used as a cloth chip substrate 2, 12 circular magnet blocks 1 with the diameter of about 3mm are taken as masks, an iron plate with a plane upper surface or an iron box 3 is taken as a base, and food-grade silicon rubber is selected as a modifier. The cloth chip substrate 2 can be obtained in various ways, for example, a white cloth piece with a suitable size is purchased directly from the market as the cloth chip substrate 2, or a cloth piece with a suitable size is cut from an existing white cloth (e.g., a white coat) as the cloth chip substrate 2, the size of the cloth piece can be selected according to needs, for example, 7.5cm × 3cm, the purchased or self-cut white cloth piece is cleaned and dried, and then is laid on the upper surface of the iron box 3 or the iron plate, 12 magnet blocks 1 are uniformly placed on the surface of the cloth piece at intervals, and the arrangement mode of the magnet blocks 1 can be determined according to needs, for example, 3 × 4, 2 × 6, and the like. According to the following steps of 1: 1 to obtain a prepolymer of the silicone rubber (PDMS, SE901 electronic pouring sealant, quick-drying adhesive, tung oil, waterproof adhesive and the like can also be used). Dipping a small amount of silicon rubber prepolymer by a brush, uniformly coating the silicon rubber prepolymer on the surface of the cloth piece, and obliquely placing the iron box 3 or the iron plate after uniform coating so that a small amount of redundant silicon rubber prepolymer naturally flows down. Standing for 30 minutes, heating for 2 hours at 70 ℃ in an oven to promote the curing of the silicon rubber, and stripping all the magnet blocks 1 after the silicon rubber is cured to obtain the silicon rubber modified dot matrix fabric chip.
Example 2
When the type of the cloth chip is a duct type, a binding tape prepared by a sealing material is selected as a mask and a cylinder 4 is selected as a base in step S2, and the mask and the cloth chip base 2 are mounted in such a manner that the cloth chip base 2 is laid along a side wall of the base and the cloth chip base 2 is bound and fixed using the mask. And uniformly coating the modifier on the surface of the cloth chip substrate 2, standing for 30-60 minutes, and heating in an oven at 50-80 ℃ to promote the curing of the silicon rubber.
Specifically, as shown in fig. 3, for a simple pipeline microchip, reference may be made to a tie-dyeing technique, the type of the fabric chip is a pipeline type, a white fabric piece with a suitable size is taken as a fabric chip substrate 2 after being cleaned and dried, an iron wire 5 is taken as a tie-up tape, the thickness of the iron wire 5 can be selected as required, for example, 0.5mm, a cylindrical hollow tube is taken as a base, the thickness of the circular hollow tube can be selected as required, for example, 6.5mm, for convenience of carrying and storage, cylindrical hollow tubes with different sizes are sleeved together, when in use, a required section can be taken down, the obtaining mode of the fabric chip substrate 2 is the same as that in embodiment 1, and the size of the fabric chip substrate 2 is selected to be 9cm × 9 cm. With cloth chip base 2 around the pipe wall of hollow tube, then tie up with iron wire 5 and tie up, iron wire 5 is the helix setting, selects the number of turns of iron wire 5 winding according to required pipeline quantity. According to the following steps of 1: 1 to obtain a prepolymer of the silicone rubber (PDMS, SE901 electronic pouring sealant, quick-drying adhesive, tung oil, waterproof adhesive and the like can also be used). Dipping a small amount of silicon rubber prepolymer by a brush, uniformly coating the silicon rubber prepolymer on the surface of the cloth piece, vertically arranging a chip base, naturally flowing down the redundant silicon rubber prepolymer, standing for 30-60 minutes, heating in an oven at 50-80 ℃ for 2 hours to promote the solidification of silicon rubber, stripping all iron wires 5 after the silicon rubber prepolymer is solidified, and taking down the cloth ring to obtain the silicon rubber modified iron wire 5 tie-dyed pipeline cloth chip. When in use, a sample is spotted on a cloth base pipeline formed at the position covered by the iron wire 5 on the cloth ring for experiment.
Because paper is easy to deform, the paper chip is difficult to implement by referring to a method of a tie-dyeing technology by using the iron wire 5 as a mask, and the masks are easy to obtain, so that the manufacturing cost of the cloth chip is greatly reduced, and the method can be realized in a common laboratory.
Example 3
When the type of the cloth chip is a star type, as shown in fig. 4, a laser engraving machine is used to engrave a sheet-like body 6 with poor water absorption according to a predetermined pattern in step S2, the sheet-like body is engraved into a star shape, a mask is obtained, a flat plate is selected as a base, and the mask and the cloth chip substrate 2 are mounted in such a manner that the cloth chip substrate 2 is laid flat on the base, and then the mask is attached to the surface of the cloth chip substrate 2. After the modifying agent is uniformly applied to the surface of the fabric chip substrate 2 in step S3, the base is tilted so that the excess modifying agent on the fabric chip substrate 2 naturally flows down, or the fabric chip substrate 2 is hung so that the excess modifying agent on the fabric chip substrate 2 naturally flows down. And uniformly coating the modifier on the surface of the cloth chip substrate 2, standing for 30-60 minutes, and heating in an oven at 50-80 ℃ to promote the curing of the silicon rubber.
The cloth has better toughness and higher strength than paper, so that the engraved rubberized fabric or label paper can be conveniently adhered to the surface of the cloth to be used as a mask, and the paper cannot be used by the method.
As a second aspect of the present invention, there is provided a cloth chip, which is prepared by the above-described preparation method of a cloth chip.
Example 4
In order to verify the testing effect of the cloth chip, the cloth chip prepared in example 1 was used to perform a test, a series of standard solutions of paeonol and an ethanol extract of cortex moutan (produced in the mountains of southern mountain of turnip lake) were prepared, the cloth chip was tested using a folacin reagent, the result was photographed using a macro camera, and then analyzed using ImageJ software, and the result of the total amount of paeonol detected is shown in fig. 5, the content of paeonol in the cortex moutan measured was about 5.4% higher than that of the general cortex moutan product, which is similar to the result of the paper chip prepared by a laser paper cutting method and the result of the ultraviolet spectrophotometry, and higher than the result of the high performance liquid chromatography determined by pharmacopoeia, because the detection result of the method and the ultraviolet spectrophotometry is the content of the total phenols in the cortex moutan, and further proves that the cloth chip prepared by the above method can be used in place of the paper chip, in addition, the portability of the cloth chip is considered, the cloth chip has great advantages of quality control or spot check in the links of planting, harvesting, selling and the like of medicinal materials, and has strong practicability; compared with a paper chip, the cloth chip can be repeatedly cleaned, so that only a small amount of chips need to be carried during detection, and the paper chip is disposable, and is inconvenient for field detection of cortex moutan samples in the field if a large amount of samples need to be analyzed, and obviously, the cloth chip also has advantages.
The cloth chip can be folded for multiple times, so that the cloth chip can be conveniently switched between a three-dimensional state and a one-dimensional state, multiple experiments can be carried out in the three-dimensional state, the one-dimensional state is convenient to observe and detect, and the paper chip obviously cannot realize the point. The cloth chip can be cleaned by clear water after the experiment is finished, and can be reused subsequently, while the paper chip can not be finished. The cloth chip, especially the cloth chip which is intelligent and non-toxic, can be widely applied to the aspects of real-time monitoring of human health and the like when being combined with clothes, and is also superior to the paper chip. In conclusion, the fabric chip has the advantages of a paper chip and a plurality of advantages at the same time, and is the research direction of novel microchips.
The invention has been described in an illustrative manner, and it is to be understood that the invention is not limited to the precise form disclosed, and that various insubstantial modifications of the inventive concepts and solutions, or their direct application to other applications without such modifications, are intended to be covered by the scope of the invention. The protection scope of the present invention shall be subject to the protection scope defined by the claims.
Claims (4)
1. A preparation method of a cloth chip is characterized by comprising the following steps: the preparation method of the cloth chip comprises the following steps
Selecting cloth with proper size, cleaning and airing to serve as a cloth chip substrate;
selecting a mask and a base according to the type of the cloth chip, placing the cloth chip base on the base, and fixedly placing the mask on the cloth chip base;
preparing a modifier, and uniformly coating the modifier on the surface of the cloth chip substrate;
after the modifier is solidified, removing the mask to obtain the cloth chip;
when the type of the cloth chip is a dot matrix type, a magnet block is selected as a mask, a flat plate made of ferromagnetic substances is selected as a base, and the mask and the cloth chip substrate are mounted in the following mode:
the cloth chip substrate is flatly laid on the base, and the mask is fixedly placed on the cloth chip substrate by utilizing the magnetism between the magnet block and the ferromagnetic substance;
after the modifier is uniformly coated on the surface of the cloth chip substrate, the base is obliquely arranged, so that the redundant modifier on the cloth chip substrate naturally flows down;
when the type of the cloth chip is a pipeline type, a binding band prepared by a sealing material is selected as a mask, a cylinder is selected as a base, and the mask and the cloth chip substrate are mounted in the following mode:
laying the cloth chip substrate along the side wall of the base, and binding and fixing the cloth chip substrate by using a mask;
when the type of the cloth chip is star-shaped, a laser engraving machine is used for engraving a sheet-shaped body with poor water absorption according to a preset pattern to obtain a mask, a flat plate is selected as a base, and the mask and the cloth chip substrate are mounted in the following mode:
flatly paving the cloth chip substrate on the base, and then attaching the mask to the surface of the cloth chip substrate;
after the modifier is uniformly coated on the surface of the cloth chip substrate, the base is obliquely arranged to enable the redundant modifier on the cloth chip substrate to naturally flow down, or the cloth chip substrate is hung up to enable the redundant modifier on the cloth chip substrate to naturally flow down.
2. The method for producing a cloth chip according to claim 1, characterized in that: and uniformly coating the modifier on the surface of the cloth chip substrate, standing for 30-60 minutes, and heating in an oven at 50-80 ℃ to promote the curing of the silicone rubber.
3. The method for producing a cloth chip according to claim 1, characterized in that: the modifier is any one of silicon rubber, polydimethylsiloxane, SE901 electronic pouring sealant, quick-drying adhesive, tung oil and waterproof adhesive.
4. A fabric chip characterized by: the cloth chip is prepared by the preparation method of the cloth chip of any one of claims 1 to 3.
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| CN201910167175.4A CN109806921B (en) | 2019-03-06 | 2019-03-06 | Preparation method of cloth chip and cloth chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910167175.4A CN109806921B (en) | 2019-03-06 | 2019-03-06 | Preparation method of cloth chip and cloth chip |
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| CN109806921B true CN109806921B (en) | 2021-07-23 |
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| CN111595843B (en) * | 2020-05-20 | 2022-06-03 | 中国科学院新疆理化技术研究所 | Preparation method and application of viscous sampling detection paper for arrayed colorimetric analysis |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19748295A1 (en) * | 1997-10-31 | 1999-05-06 | Max Planck Gesellschaft | Element with extremely water-repellent drying zones on the surface |
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN102119056A (en) * | 2008-07-11 | 2011-07-06 | 莫纳什大学 | Method of fabricating microfluidic systems |
| US8343437B2 (en) * | 2008-06-04 | 2013-01-01 | Jp Laboratories, Inc. | Monitoring system based on etching of metals |
| CN103372469A (en) * | 2012-04-24 | 2013-10-30 | 中国科学院化学研究所 | Micropore thin film micro-fluidic chip as well as preparation method and application thereof |
| CN106119095A (en) * | 2016-06-30 | 2016-11-16 | 中国科学院重庆绿色智能技术研究院 | A kind of film substrate micro through hole array biochip and preparation method thereof |
| CN106563516A (en) * | 2016-11-08 | 2017-04-19 | 安徽中医药高等专科学校 | Preparation method of microchip for teaching |
| CN107921431A (en) * | 2015-04-07 | 2018-04-17 | 源鉴定私人有限公司 | fluid chip |
| CN207851458U (en) * | 2018-01-02 | 2018-09-11 | 京东方科技集团股份有限公司 | Mask plate and sealant curing apparatus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1157270A1 (en) * | 1999-02-03 | 2001-11-28 | Aclara BioSciences, Inc. | Multichannel control in microfluidics |
| US7993821B2 (en) * | 2005-08-11 | 2011-08-09 | University Of Washington | Methods and apparatus for the isolation and enrichment of circulating tumor cells |
-
2019
- 2019-03-06 CN CN201910167175.4A patent/CN109806921B/en not_active Expired - Fee Related
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19748295A1 (en) * | 1997-10-31 | 1999-05-06 | Max Planck Gesellschaft | Element with extremely water-repellent drying zones on the surface |
| US8343437B2 (en) * | 2008-06-04 | 2013-01-01 | Jp Laboratories, Inc. | Monitoring system based on etching of metals |
| CN102119056A (en) * | 2008-07-11 | 2011-07-06 | 莫纳什大学 | Method of fabricating microfluidic systems |
| CN101817495A (en) * | 2010-03-25 | 2010-09-01 | 湖南大学 | Micro fluid control chip and preparation method and application thereof |
| CN103372469A (en) * | 2012-04-24 | 2013-10-30 | 中国科学院化学研究所 | Micropore thin film micro-fluidic chip as well as preparation method and application thereof |
| CN107921431A (en) * | 2015-04-07 | 2018-04-17 | 源鉴定私人有限公司 | fluid chip |
| CN106119095A (en) * | 2016-06-30 | 2016-11-16 | 中国科学院重庆绿色智能技术研究院 | A kind of film substrate micro through hole array biochip and preparation method thereof |
| CN106563516A (en) * | 2016-11-08 | 2017-04-19 | 安徽中医药高等专科学校 | Preparation method of microchip for teaching |
| CN207851458U (en) * | 2018-01-02 | 2018-09-11 | 京东方科技集团股份有限公司 | Mask plate and sealant curing apparatus |
Non-Patent Citations (3)
| Title |
|---|
| 制造玻璃微流控芯片的简易加工技术;殷学锋等;《仪器装置与实验技术》;20030131;第31卷(第1期);全文 * |
| 微芯片化学实验设计;吴剑等;《中国教育技术装备》;20130731;全文 * |
| 纸基微流控芯片的研究进展及趋势;吴静等;《中国造纸学报》;20181231;第33卷(第02期);全文 * |
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