CN109796556A - A kind of preparation method for the silicone hydrogel contact lens that can mechanically demould - Google Patents
A kind of preparation method for the silicone hydrogel contact lens that can mechanically demould Download PDFInfo
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- CN109796556A CN109796556A CN201910050970.5A CN201910050970A CN109796556A CN 109796556 A CN109796556 A CN 109796556A CN 201910050970 A CN201910050970 A CN 201910050970A CN 109796556 A CN109796556 A CN 109796556A
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Abstract
The present invention relates to the preparation methods for the silicone hydrogel contact lens that one kind can be demoulded mechanically.Silicone hydrogel contact lens oxygen permeability coefficient improves 2-8 times than traditional HEMA contact lenses, and oxygen permeability is to measure one of the contact lens wearing general level of the health and the most important index of comfort level.Silicone hydrogel contact lens are contact lenses industry update trend, and high efficiency, low cost production is research direction.After traditional aggregated solidification of HEMA liquid formulations, dry eyeglass is very hard, generally dry eyeglass is set to separate with plastic mould and obtain eyeglass using mechanical means, carrying out simple aquation again can packaging sterilizing, silicone hydrogel lenses material property is soft, production cannot be demoulded by the way of HEMA technique, the present invention improves silicone hydrogel contact lens formula, improve the hardness of dry eyeglass, thus it can make dry eyeglass and mold separation with the machinery of HEMA technique, it can mechanically demould, the equipment for not only having used HEMA eyeglass to produce, reduce cost, also improve efficiency.
Description
Technical field
The present invention relates to the preparation methods for the silicone hydrogel contact lens that one kind mechanically demoulds.
Background technique
The oxygen permeability of contact lenses is to measure to wear one of the general level of the health and the most important index of comfort level.Silicone-hydrogel
The contact lenses of material improve 2-8 times than the oxygen permeability coefficient of traditional HEMA contact lenses, open contact lenses Xiang Gengjian
The update in the more comfortable direction of health.Contact lenses production company leading in the world has successfully developed a few money function admirables
Product, as " Biofinity one hundred regards bright " of optics (CooperVision) is won in library；" the Europe of Johnson & Johnson (Johnson & Johnson)
Comfortably " etc., with the excellent properties of technical products of new generation, world's contact lenses industry is led to update rapidly.Traditional
After the aggregated solidification of HEMA liquid formulations, dry eyeglass is very hard, generally separates dry eyeglass with plastic mould using mechanical means
And eyeglass is obtained, then carrying out simple aquation can packaging sterilizing.The material property of silicone hydrogel lenses, with traditional HEMA material
Eyeglass is compared, soft very much, cannot generally be demoulded using the mechanical system of HEMA technique.Contact lenses leading in the world produce public
Production procedure will be greatly improved when being upgraded to silicone-hydrogel product by HEMA eyeglass for department, can generally abandon original HEMA mirror
The mechanical system of piece demoulds, and which improves production costs.50%- is also typically included in the production process of silicone-hydrogel
100% alcoholic solution cleaning step, and HEMA product is usually only washed with water, this also increases being produced into for silicone-hydrogel product
This.To reduce production cost, the present invention improves silicone hydrogel contact lens formula.The hardness of dry eyeglass is improved,
Thus dry eyeglass can be made mechanically to demould with mold separation with the machinery of HEMA technique.And cleaning process is also big
It is big to simplify.Dry eyeglass can clean the dimensionally stable that can reach product in pure water.
Summary of the invention
To reduce production cost, the present invention improves silicone hydrogel contact lens formula.Improve dry eyeglass
Hardness thus can make dry eyeglass and mold separation with the machinery with HEMA technique.And cleaning process also greatly simplifies.It is dry
Eyeglass can clean the dimensionally stable that can reach product in pure water.
Technical solution
To achieve the goals above, the present invention provides a kind of system of silicone hydrogel contact lens that can mechanically demould
Preparation Method, comprising the following steps:
(1) polymerization reaction molding occurs in the full mould mold of plastics for the polymer fluid that preparation finishes, and the formula includes:
A. at least containing a kind of following siloxane polymerization monomer, such as general formula I:
Wherein: R1 is H or CH3；R2 is the alkyl of C2~3 or the alkyl containing 1-OH substituent group, and R3, R4, R5 can be equal
ForOr at most there are two group be methyl.
B. containing a kind of following siloxane polymerization crosslinking agent, such as general formula II:
Wherein: R1 is CH2-CH2 or C3H6；R2 is that molecular weight is polyethylene glycol groups less than 2,000；R3 is fatty two
Isocyanate group such as isophorone diisocyanate base；R4 is that molecular weight is dimethyl silicone polymer less than 4,000.
C. two or more hydrophilic monomer, it is necessary to contain N- methyl-Nvinylacetamide, N- vinyl pyrrole
One kind or two kinds of alkanone, N,N-DMAA.
(2) after the completion of polymerization, mechanically divided mould and eyeglass.
(3) eyeglass obtained by is through alcohol-water mixture or 100% water washing, sterilizing, packaging.
Wherein, the weight of component a is the 10-30% of total formulation weight, and the weight of component b is that total weight is 1-10%, group
It is 40-80% that the weight of part c, which is total weight,.
Also comprising at least one crosslinking agent, a kind of initiator, a kind of ultraviolet absorber.The preferred dimethacrylate of crosslinking agent
Glycol ester, additional amount are the 0.1-0.5% of total weight.A kind of preferred azodiisobutyronitrile of thermal initiator, additional amount is gross weight
The 0.5-0.7% of amount.A kind of preferred 2- of ultraviolet absorber (2 '-hydroxyls -5 '-methylacryoyloxyethyl phenyl) -2H- benzo three
Azoles, additional amount are the 0.5-1.8% of total weight；
Azodiisobutyronitrile thermal-initiated polymerization, it is characterised in that: the method is will to polymerize mixed liquor to be added in mold, will
Mold is put into nitrogen oven.Under logical condition of nitrogen gas, 85 degree are at the uniform velocity warming up in heat preservation 30 minutes, 5 minutes at 45 degree,
1h is kept the temperature, is again heated to 100 degree, keeps 1h.Cooled to room temperature again.
Specific embodiment
The following examples are intended to illustrate the invention, but is not limited to range of rights and interests of the invention.
Embodiment 1
The preparation of 1.1 eyeglasses
Following materials: A, B, C, F, G, H, E, D are sequentially added in the there-necked flask of the 5L with stirring.
A N,N-DMAA: 5 parts
B N- methyl-Nvinylacetamide: 13 parts
C n-vinyl pyrrolidone: 20 parts
D methacryloxypropyl three (trimethylsiloxane group) silane: 20 parts
E hydroxyethyl methacrylate: 40 parts
F ethylene glycol dimethacrylate: 1 part
G azodiisobutyronitrile: 0.5 part
H 2- acrylic acid 2- (4- benzoyl -3- hydroxyphenoxy) ethyl ester: 1.0 parts
Stirring at low speed under 25 degree dissolves material all, is uniformly mixed, mixing time 0.5 hour or more.Gained mixed liquor
Pressure filter filtering by 0.2 micron pore size, obtains polymer fluid.By automatic filling machine fluid injection, molding, mould then will be got togather
Mold is transferred to curing oven.Program curing are as follows: room temperature rises to 65 degree and keeps the temperature 30 minutes, then 1h is at the uniform velocity warming up to 95 degree, heat preservation
1h, stops heat, and cooled to room temperature contains the plastic mould of dry eyeglass after being solidified.
1.2 mechanical systems are de- to touch: touching lathe using contact lenses numerical control is de-, i.e., tradition HEMA contact lenses mechanical equipment will
Plastic mould and the separation of dry eyeglass.
1.3 aquations: dry eyeglass being put into 55 degree of hot water, vibrates 6h.After the completion of aquation, it is hidden that sterilizing obtains silicone-hydrogel
Shape eyeglass.
The test of 1.4 eyeglasses
A oxygen permeability coefficient:
Using 201T type oxygen flow instrument (Creathch/Rehder-Dev Co, Americanized), using polarography according to national standard
GBT 11417.7-2012 is measured, and the results are shown in Table 1 Dk unit described herein are as follows: 42*10-11(cm2/s)[mLO2/
(mL.hPa)].
The detection of B ultraviolet permeability:
Transmitance detection is carried out using SP-1920 ultraviolet specrophotometer (manufacture of Shanghai spectrum), according to GBT11417.5-
Visible light transmittance of 2012 scan mirrors in 380nm~800nm wave band.
T% value is the wave band transmitance average value in this case.
C mechanics properties testing:
It is measured using Instron mechanics machine
Examples 1 to 7:
In addition to formula is changed, remaining operation operates Examples 1 to 7 similarly to Example 1, the results are shown in Table one:
One Examples 1 to 7 formula of table and main result
Embodiment 2
It is sequentially added in the there-necked flask of the 10L with stirring following: A, B, C, F, G, H, E, D.
A N,N-DMAA: 5 parts
B N- methyl-Nvinylacetamide: 13 parts
C n-vinyl pyrrolidone: 20 parts
D methacryloxypropyl three (trimethylsiloxane group) silane: 20 parts
E hydroxyethyl methacrylate: 40 parts
F ethylene glycol dimethacrylate: 1 part
G azodiisobutyronitrile: 0.5 part
H 2- acrylic acid 2- (4- benzoyl -3- hydroxyphenoxy) ethyl ester: 0.5 part
Stirring at low speed under 25 degree dissolves material all, is uniformly mixed, mixing time 0.5 hour or more.Gained mixed liquor
Pressure filter filtering by 0.2 micron pore size, obtains polymer fluid.Fluid injection molding is carried out by full mould automatic filling machine, then will
The mold that molding is completed is transferred to curing oven.Program curing are as follows: room temperature rises to 65 degree and keeps the temperature 30 minutes, then 1h is at the uniform velocity warming up to
95 degree, 1h is kept the temperature, heat is stopped.Cooled to room temperature processing eyeglass to be demoulded after being solidified.
1.2 demouldings: use contact lenses ingot stripper c-type, demoulding rotary speed: 980r/min separates matched molds, then rotates
It obtains to the dry eyeglass of aquation.
1.3 aquations: dry eyeglass being put into 55 degree of hot water, vibrates 6h.After the completion of aquation, sterilizing obtains eyeglass.
1.4 eyeglasses test: although above having used general explanation, specific embodiment and test, having made to the present invention
Detailed description, but on the basis of the present invention, it can be made some modifications or improvements, this is to those skilled in the art
It is obvious.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the present invention
Claimed range.
Claims (8)
1. the preparation method for the silicone hydrogel contact lens that one kind can be demoulded mechanically, which is characterized in that including following step
It is rapid:
(1) polymerization reaction molding occurs in the full mould mold of plastics for the polymer fluid that preparation finishes, and the formula includes:
A. at least containing a kind of following siloxane polymerization monomer, such as general formula I:
Wherein: R1 is H or CH3；R2 is the alkyl of C2~3 or the alkyl containing 1-OH substituent group, R3, R4, R5 can beOr at most there are two group be methyl.
B. containing a kind of following siloxane polymerization crosslinking agent, such as general formula II:
Wherein: R1 is CH2-CH2 or C3H6；R2 is that molecular weight is polyethylene glycol groups less than 2,000；R3 is two isocyanide of fatty
Perester radical such as isophorone diisocyanate base；R4 is that molecular weight is dimethyl silicone polymer less than 4,000.
C. two or more hydrophilic monomer, it is necessary to contain N- methyl-Nvinylacetamide.N- ethenyl pyrrolidone
Ketone；One kind or two kinds of N,N-DMAA.
(2) after the completion of polymerizeing, mechanically divided mould and eyeglass.
(3) gained eyeglass is through alcohol-water mixture or 100% water washing, sterilizing, packaging.
2. the weight of component a is the 10-30% of total formulation weight as in claim 1 (1) the method, the weight of component b is
The 1-10% of total weight, the weight of component c are that total weight is 40-80%, also comprising at least one crosslinking agent, a kind of initiator,
A kind of ultraviolet absorber.
It include a kind of siloxane polymerization monomer component a, preferably methacryl 3. being described according to claim 1 with the method in 2
Oxygen propyl group three (trimethylsiloxane group) silane.
4. describing according to claim 1 with the method in 2, include a kind of crosslinking agent containing polyethylene glycol and dimethyl silicone polymer
Component b (general formula II), wherein between polyethylene glycol and the weight ratio 0.3: 1.0 and 0.6: 1.0 of dimethyl silicone polymer, number is divided equally
Son amount is preferably between 1,000-8,000, and optimal number-average molecular weight is between 3,000-6,000.
5. describing according to claim 1 with the method in 2, the cross-linking agent component b containing polyethylene glycol and dimethyl silicone polymer is (logical
Formula II) additive amount it is small with 10%, preferably 2-8%.
It may include another crosslinking agent, preferably ethylene glycol dimethacrylate 6. being described according to claim 1 with the method in 2
Ester, additional amount are the 0.1-0.5% of total weight.Comprising a kind of preferred azodiisobutyronitrile of thermal initiator, additional amount is total weight
0.3-0.8%.Include a kind of preferred 2- of ultraviolet absorber (2 '-hydroxyls -5 '-methylacryoyloxyethyl phenyl) -2H- benzo
Triazole, additional amount are the 0.5-1.8% of total weight.
7. describing according to claim 1 with the method in 2, the separate mode of mold and eyeglass is mechanical means, such as squeezes modeling
Expect that formpiston or female mold bottom, dry eyeglass can be with mold separations.
8. being described according to claim 1 with the method in 2, dry eyeglass is put into 55 degree of hot water, vibrates 6h.Aquation is completed,
It is then placed in packaging liquid and packs, sterilize.
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| CN201910050970.5A CN109796556B (en) | 2019-01-11 | 2019-01-11 | Preparation method of mechanically demouldable silicone hydrogel contact lens |
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| CN201910050970.5A CN109796556B (en) | 2019-01-11 | 2019-01-11 | Preparation method of mechanically demouldable silicone hydrogel contact lens |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112094387A (en) * | 2020-09-07 | 2020-12-18 | 华诺森（武汉）生物医药技术有限公司 | Novel silica hydrogel contact lens |
| CN114671974A (en) * | 2022-03-31 | 2022-06-28 | 华诺森（武汉）生物医药技术有限公司 | Silicon hydrogel contact lens and formula and preparation method thereof |
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| CN102964532A (en) * | 2012-11-29 | 2013-03-13 | 海昌隐形眼镜有限公司 | Organic silicon hydrogel material of contact lenses and preparation method thereof |
| CN105061674A (en) * | 2015-08-10 | 2015-11-18 | 爱生华(苏州)光学有限公司 | Novel fluorosilicone-containing silicone hydrogel contact lens formula selection and new process |
| CN106366241A (en) * | 2015-07-23 | 2017-02-01 | 爱博诺德（北京）医疗科技有限公司 | Ophthalmic material having fluorescence property, and uses thereof |
| CN108102038A (en) * | 2016-11-25 | 2018-06-01 | 丹阳市雅本化工技术有限公司 | A kind of hydrogel |
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2019
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102964532A (en) * | 2012-11-29 | 2013-03-13 | 海昌隐形眼镜有限公司 | Organic silicon hydrogel material of contact lenses and preparation method thereof |
| CN106366241A (en) * | 2015-07-23 | 2017-02-01 | 爱博诺德（北京）医疗科技有限公司 | Ophthalmic material having fluorescence property, and uses thereof |
| CN105061674A (en) * | 2015-08-10 | 2015-11-18 | 爱生华(苏州)光学有限公司 | Novel fluorosilicone-containing silicone hydrogel contact lens formula selection and new process |
| CN108102038A (en) * | 2016-11-25 | 2018-06-01 | 丹阳市雅本化工技术有限公司 | A kind of hydrogel |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112094387A (en) * | 2020-09-07 | 2020-12-18 | 华诺森（武汉）生物医药技术有限公司 | Novel silica hydrogel contact lens |
| CN114671974A (en) * | 2022-03-31 | 2022-06-28 | 华诺森（武汉）生物医药技术有限公司 | Silicon hydrogel contact lens and formula and preparation method thereof |
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| CN109796556B (en) | 2021-06-11 |
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