CN109771304B - Tooth desensitizer containing regenerative medical material and preparation method thereof - Google Patents
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Abstract
The invention provides a tooth desensitizer product containing regenerative medical materials and a preparation method thereof; the tooth desensitizer product of the regenerative medical material is mainly prepared from the following raw materials: regenerative medical materials, matrix materials, dispersants, gelling agents, and others; the preparation method adopts an anhydrous vacuum high-speed shearing dispersion process. The invention provides a tooth desensitizer product containing regenerative medical materials, which has the main functional components of the regenerative medical materials, has the effects of preventing and treating tooth allergy, can improve the oral environment, and has certain treatment and prevention effects on periodontal diseases, oral ulcer and dental plaque caries.
Description
Technical Field
The invention relates to the technical field of biomedical materials, in particular to a tooth desensitizer containing regenerative medical materials and a preparation method thereof.
Background
Dentin sensitivity means that exposed dentin generates short and sharp pain to external stimuli and cannot be attributed to tooth defects or lesions caused by other specific reasons, and typical stimuli include temperature stimulation (cold and hot), chemical stimulation (sour and sweet), mechanical stimulation (friction or hard biting substances), osmotic pressure and the like, and the stimuli are characterized by quick onset, sharp pain and short time. Tooth hypersensitivity is not an independent disease but is a symptom common to various dental diseases. In 2008, the national investigation on dentin sensitivity epidemiology of adults, 29.7% of adults 20-69 years old have dentin hypersensitivity, the high incidence age is 50-59 years old, the prevalence rate is 39.1%, and the proportion of women is higher than that of men. The sensitive good hair site of dentin was the premolar, followed by the first molar.
The dentin hypersensitivity is caused by a plurality of causes, and all the causes can cause the integrity of enamel on the surface of teeth to be damaged, so that various tooth diseases with exposed dentin, such as abrasion (frequently biting hard objects, such as small walnuts, meat bones and the like, and grinding teeth at night), tooth fracture caused by trauma, wedge-shaped defect of a tooth neck caused by improper long-term tooth brushing, dental caries, tooth root exposure caused by periodontal atrophy and the like can all cause the dentin hypersensitivity; there are other etiologies, such as systemic factors (psychological, mental state), etc.
The pathogenesis of dental hypersensitivity is not well understood, and there are three hypotheses:
(1) the neurology theory suggests that the dentin contains pulp nerve endings, so that the sensation is transmitted from the surface layer of the dentin to the pulp. However, no consistent findings have been obtained from morphological and functional observations. Many scholars think that: unmyelinated nerves within the odontoblasts of the pulp only partially enter the inner lining of the prophase dentin and dentin, and no nerve structures are visible outside 2/3. Many experimental results also do not support the notion that the response of nerves to various stimuli is direct. Potassium chloride, histamine, acetylcholine and the like act on superficial dentin and do not cause pain; local anesthetics acting on the dentinal surface also fail to reduce dentinal sensitivity;
(2) the theory of dentinal fiber transmission is that the protoplasm of the odontoblast contains acetylcholinesterase, which can cause nerve conduction and pain when stimulated. Against the opinion, it was thought that experimental interference with human dentinoblasts did not reduce dentinal sensitivity, indicating that the odontoblasts did not have sensorial properties and may only play a passive role in dentinal hypersensitivity;
(3) the theory of hydrodynamics is that the pain caused by air, hypertonic solution or temperature stimuli is due to the fact that these stimuli move the liquid in the dentinal tubules, mechanically agitate the contents of the pulp, indirectly excite the free nerve endings therein, transmit impulses and generate pain sensation. The energy accompanying the movement of the liquid may be converted into electrical signals by the receptors of the pulp. Approximately 25% of the dentin volume is occupied by free liquid, which is similar in composition and properties to other body fluids of the body and is in fluid communication with the pulp tissue. The dentinal tubules are capillaries with a diameter of 0.8 to 2.5 μm, and thus, the hydrodynamic effect depends on permeability of the dentinal tubules or the condition of the dentinal surface. The stimulus causing the dentine fluid to move outward is air blow drying, hypertonic solution, cold stimulus, and the like. The stimulus for moving the dentin fluid inward may be mechanical stimulus or heat. Dentin exposure is initially very sensitive and later natural relief of sensitivity is a result of mineral deposition within the dentinal tubules or the formation of restorative dentin by the pulp.
In terms of pathogenesis, the method of treating dentinal hypersensitivity mainly addresses 2 aspects: one is to block dentinal tubules, prevent or reduce dentinal tubule fluid flow, and the other is to inhibit excitability of pulp nerves. Sealing the dentinal tubules is a more effective method of treating dentinal hypersensitivity. In addition, plaque formation is an important factor, and plaque build-up can lead to demineralization of the root structure and opening of the tubules of the dentin. Thus, promotion of tooth remineralization and control of plaque formation may also serve as an indirect route to the treatment of dentinal hypersensitivity.
Clinically, there are four major mechanisms of tooth desensitization: the blocking effect: an agent capable of producing an insoluble precipitate is applied to the tooth surface to produce a precipitate that blocks the dentinal tubules. ② corrosion action: the protein in dentin is coagulated and denatured by corrosive drugs, and the permeability of tubules is reduced. ③ covering action: using resin material to act on the surface of dentin to form a protective film to isolate stimulation; biological effect: the medicine can activate the activity of dentin cells to form restorative dentin, calcify dentin and isolate stimulation. At present, marketA common occlusion desensitizing material used in the field is fluoride, which forms deposits CaF on the tooth surface2Occluding the exposed tubules, thereby alleviating sensitive symptoms; but often do not seal completely and are susceptible to saliva or brushing and are quickly removed. The common medicament in the aspect of corrosion desensitization is cresol formaldehyde, phenols have strong permeability and corrosivity, and can fix organic matters in dentin tubules to form a layer of protective film to block the stimulation of the external world to dental pulp; formaldehyde can also inhibit the formation of dental plaque, thereby effectively alleviating the symptoms of allergy; however, phenols have strong toxicity and irritation, and can aggravate irritation and damage to surrounding tissues, so the desensitizer has a relatively wide application range and is used with caution for people with severe abrasion and degree III sensitivity. In the aspect of covering desensitization, the smooth enamel surface is changed into a honeycomb structure by an acid etching agent, so that dentin tubules are opened, and a collagen reticular structure is exposed; then, low-viscosity hydrophilic resin monomer is adopted to permeate into the micropores so as to be mixed with the dentin collagen fibers, thereby achieving the purpose of desensitization; this procedure causes significant damage to the enamel. In terms of biological action, biomaterials such as hydroxyapatite and calcium phosphate are generally used to calcify dentin and isolate irritation, but these materials are slow to act and must be used frequently.
In view of the defects of the existing tooth desensitizer products, the inventor proposes to design a novel tooth desensitizer containing regenerative medical materials, a preparation method and a use method based on years of design and manufacturing experience of dental medical appliance products.
Disclosure of Invention
The invention mainly aims to overcome the defects of the existing tooth desensitizer products and provides a novel tooth desensitizer containing regenerative medical materials, a preparation method and a use method.
The purpose and the technical problem to be solved of the invention are realized by adopting the following technical scheme. The specific technical scheme is as follows:
in a first aspect, the present invention provides a dental desensitizer product comprising regenerative medical materials, comprising the following components: the regenerative medicine material comprises a regenerative medicine material, a matrix material, a dispersing agent, a gelling agent and other components, wherein the weight contents of the components are as follows:
1-40% of regenerative medical material
10-50% of matrix material
5 to 30 percent of dispersant
0.1 to 5 percent of gelling agent
The rest is 0.1-40%
Preferably, the weight contents of the components are as follows:
5-30% of regenerative medical material
20-30% of matrix material
10 to 20 percent of dispersant
0.5 to 4.5 percent of gelling agent
The rest is 5 to 35 percent
The weight of the dental desensitizer product containing regenerative medical materials can be known weight units such as mu g, mg, g, kg, etc., or multiples thereof, such as 1/10, 1/100, 10, 100, etc.;
the regenerative medical material can be prepared by adopting a method of CN106421889A, and comprises the following components in percentage by weight: 12-38% of SiO2, 1-3% of Na2O, 1-3% of K2O, 15-29% of CaO, 1-32.5% of P2O5, 1-5% of inositol hexaphosphate and 1-5% of inositol phosphate;
the particle size range of the regenerative medical material is 0.1-50 μm, preferably 0.1-30 μm;
the matrix material is selected from: one or more of glycerol, butanediol, polyethylene glycol, propylene glycol, hexanediol, polypropylene glycol and sorbitol;
the dispersant is selected from one or a mixture of more of alkyl glycoside, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, fatty acid polyglycol ester and sucrose ester;
the gelling agent is one or a mixture of more of carbomer, guar gum, xanthan gum, gelatin, methylcellulose, sodium carboxymethylcellulose, sodium hydroxyethyl cellulose, hydroxypropyl methylcellulose and guar gum;
the other ingredients are selected from one or more of thickening agent, flavoring agent and perfume;
wherein the weight percentage of the thickening agent, the flavoring agent and the spice in the tooth desensitizer is as follows:
5 to 30 percent of thickening agent
0-5% of flavoring agent
0.1 to 5 percent of aromatic
Wherein the thickening agent is one or a mixture of more of fumed silica, bentonite or diatomite;
the flavoring agent is selected from one or more of acesulfame potassium, saccharin sodium, aspartame, erythrose or xylitol;
the aromatic is selected from alcohol or terpenoid spice, and the aroma comprises herba Menthae, flos Jasmini sambac, fructus Citri Limoniae, green tea or black tea;
the tooth desensitizer product containing regenerative medical materials is a paste gel or paste;
the invention also provides a preparation method of the tooth desensitizer product, which is an anhydrous vacuum high-speed shearing and dispersing process and comprises the following steps:
adding a matrix material, a dispersing agent and a gelling agent according to a formula under the conditions of vacuum and high-speed shearing dispersion, shearing and dispersing for 10-120min, standing for 60-120min to obtain a mixture A, then adding a regenerative medical material and other components according to the formula, shearing and dispersing for 10-120min under the vacuum condition, and standing for 10-60 min to obtain a tooth desensitizer product containing the regenerative medical material.
Specifically, the preparation method of the tooth desensitizer product containing the regenerative medical material comprises the following steps:
1) adding a matrix material, a dispersing agent and a gelling agent into a high-speed shearing dispersion machine for dispersion, wherein the vacuum degree is-50 to-100 KPa, the shearing dispersion speed is 2000-10000 r/min, the dispersion time is 10 to 120min, and standing for 60 to 120min to obtain a mixture A;
2) breaking vacuum, adding the regenerated medical material and other components according to the formula, adding the regenerated medical material and other components into the mixture A for dispersing, wherein the vacuum degree is-50 to-100 KPa, the shearing and dispersing speed is 2000-10000 r/min, the dispersing time is 10 to 120min, and standing for 60 to 120min to obtain the tooth desensitizer product containing the regenerated medical material.
The invention also provides a tooth desensitizer product containing the regenerative medical material, which has the main functional components of the regenerative medical material, has the effects of preventing and treating tooth allergy, can improve the oral environment, and has certain treatment and prevention effects on periodontal diseases, oral ulcer and dental plaque caries.
The tooth desensitizer product containing regenerative medical materials and the preparation method thereof provided by the invention have the following beneficial effects:
(1) the regenerated medical material contained in the tooth desensitizer product provided by the invention has the specific surface area of about 180 m2The specific surface area of the material with the same granularity is 100 times (the specific surface area of the material with the same granularity is about 1.8 m)2/g), great reactivity; in addition, the regenerative medical material contains a large amount of high-coordination silicon elements, can quickly react with body fluid, and further improves the biological activity of the system;
(2) the tooth desensitizer product provided by the invention can quickly relieve dentin hypersensitivity. After the regenerative medical material in the tooth desensitizer product is contacted with saliva, ion exchange is carried out immediately to release potassium ions; potassium ions can depolarize the sensory nerve of the dental pulp, reduce nerve excitability, interrupt the transmission of pain, thereby relieving dentinal sensitivity symptoms;
(3) the tooth desensitizer product provided by the invention can be used for quickly preventing and radically treating the dentin hypersensitive symptom. After the tooth desensitizer product is contacted with saliva, hydroxyapatite can be quickly formed at the mouth and the interior of the exposed dentinal tubule, so that the dentinal tubule is sealed, a new tooth enamel surface is induced to form, the permeability of the dentinal tubule is changed, and the phenomenon of dentinal hypersensitivity is fundamentally eliminated;
(4) the tooth desensitizer product provided by the invention can improve the oral environment and has certain treatment and prevention effects on periodontal diseases, oral ulcer and dental plaque caries. The regenerated medical material in the tooth desensitizer product is in contact with saliva and then undergoes ion exchange, so that the local oxygen pressure and pH value can be increased, the tooth desensitizer product has an antibacterial effect, and anaerobic streptococcus, streptococcus A, staphylococcus epidermidis, neisseria, spirochete, candida and the like in the oral cavity can be inhibited, and the onset of periodontal disease, gingivitis, oral ulcer, decayed teeth and the like can be inhibited. In addition, the regenerative medical material has unique surface activity, and when the regenerative medical material is contacted with soft tissues, a three-dimensional network structure is quickly formed, peripheral cells, fibrin and collagen are adsorbed, and the healing of oral ulcer is promoted.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a tooth desensitizer product containing regenerative medical materials, which comprises the following components: regenerative medical materials, matrix materials, dispersants, gelling agents, and other ingredients.
Wherein the weight contents of the components are as follows:
1-40% of regenerative medical material
10-50% of matrix material
5 to 30 percent of dispersant
0.1 to 5 percent of gelling agent
The rest is 0.1-40%
Preferably, the weight contents of the components are as follows:
5-30% of regenerative medical material
20-30% of matrix material
10 to 20 percent of dispersant
0.5 to 4.5 percent of gelling agent
The rest is 5 to 35 percent
The weight in one of the above dental desensitizer products containing regenerative medical materials may be in known weight units of μ g, mg, g, kg, etc., or multiples thereof, such as 1/10, 1/100, 10, 100, etc.
The regenerative medical material can be prepared by adopting a method of CN106421889A, and comprises the following components in percentage by weight: 12-38% of SiO2, 1-3% of Na2O, 1-3% of K2O, 15-29% of CaO, 1-32.5% of P2O5, 1-5% of inositol hexaphosphate and 1-5% of inositol phosphate;
the particle size of the regenerative medical material is in the range of 0.1 to 50 μm, preferably 0.1 to 30 μm.
The matrix material is selected from: one or more of glycerol, butanediol, polyethylene glycol, propylene glycol, hexanediol, polypropylene glycol and sorbitol.
The dispersant is selected from one or a mixture of more of alkyl glycoside, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, fatty acid polyglycol ester and sucrose ester.
The gelling agent is one or a mixture of more of carbomer, guar gum, xanthan gum, gelatin, methylcellulose, sodium carboxymethylcellulose, sodium hydroxyethyl cellulose, hydroxypropyl methylcellulose and guar gum.
The other ingredients are selected from one or more of thickening agents, flavoring agents and spices.
Wherein the weight percentage of the thickening agent, the flavoring agent and the spice in the tooth desensitizer is as follows:
5 to 30 percent of thickening agent
0-5% of flavoring agent
0.1 to 5 percent of aromatic
Wherein the thickening agent is one or a mixture of more of fumed silica, bentonite or diatomite.
The flavoring agent is selected from one or more of acesulfame potassium, saccharin sodium, aspartame, erythritol or xylitol.
The aromatic is selected from alcohol or terpenoid perfume, and the aroma comprises herba Menthae, flos Jasmini sambac, fructus Citri Limoniae, green tea or black tea.
The one tooth desensitizer product containing regenerative medical materials is a paste gel or paste.
The invention also provides a preparation method of the tooth desensitizer product, which is an anhydrous vacuum high-speed shearing and dispersing process and comprises the following steps:
adding a matrix material, a dispersing agent and a gelling agent according to a formula under the conditions of vacuum and high-speed shearing dispersion, shearing and dispersing for 10-120min, standing for 60-120min to obtain a mixture A, then adding a regenerative medical material and other components according to the formula, shearing and dispersing for 10-120min under the vacuum condition, and standing for 10-60 min to obtain a tooth desensitizer product containing the regenerative medical material.
The vacuum and high-speed shear dispersion apparatus used in the present invention is an apparatus commonly used in the art to achieve the object of the present invention, and the present invention is not limited thereto, and for example, a vacuum homogenizer available from machinery equipment limited, alliance, guangzhou city, may be used.
The technical solutions of the present invention will be described below with reference to specific embodiments, and the described embodiments are only a part of embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples 1 to 5
Weighing the raw materials according to the formula of the examples 1-5 in the table 1, adding the matrix material, the dispersing agent and the gelling agent into the weighed raw materials according to the formula, shearing, dispersing and standing to obtain a mixture A, then adding the regenerative medical material and other components according to the formula, shearing and dispersing at a high speed under a vacuum condition, and standing to obtain the tooth desensitizer product containing the regenerative medical material.
The embodiment has the following technical effects:
in order to verify whether the tooth desensitizer product of the invention achieves the expected invention effect, the stability, pH and tooth desensitizing effect of the product prepared by the invention are verified by experiments:
(1) stability test
In order to verify the safety performance of the product, the stability experiment verification is carried out on the product.
The experimental method comprises the following steps: performing 2-month 50 ℃ oven storage, two months at 4 ℃ and 6 months at normal temperature, and respectively detecting the performance indexes of the products of examples 1-5;
TABLE 2 stability test in different environments
As can be seen from the table 2, after the tooth desensitizer product is stored in an oven at 50 ℃ for 2 months and at normal temperature for two months and 4 ℃ and 6 months, the tooth desensitizer product is uniform and fine, has no phenomena of putrefaction, peculiar smell, discoloration and hardening, and has no significant change in various performance indexes, so that the tooth desensitizer product has good stability and can be stored for a long time;
(2) product pH test
The experimental method comprises the following steps: mixing the product of the invention and normal saline or distilled water according to the proportion of 1: 1, filtering insoluble substances, and measuring the pH value of filtrate by using a precision pH meter; the test results are shown in table 3:
according to the detection result, the product is called alkalescence after contacting with body fluid, the pH value of the system is gradually increased along with the increase of the content of the regenerative medical material in the product, and the bacteriostatic effect can be realized by utilizing the alkaline condition;
(3) the tooth desensitization effect test proves the tooth desensitization effect by verifying the effect of the product of the invention for closing dentinal tubules
The experimental method comprises the following steps: selecting freshly extracted or recently extracted molar, removing tartar and attached soft tissue with hand-held instrument, soaking in 75% ethanol for at least 15min at an angle perpendicular to the long axis of the tooth, below occlusal enamel and above occlusal boundary of pulp cavity, and cutting dentin sheet. Etching the pulp surface of dentin sheet with 50% citric acid for 30 s, thoroughly cleaning and sterilizing, and sterilizing with high pressure steam in 0.9% NaCl (121 deg.C, 9.6 MPa, 25 min), or soaking in 75% ethanol for 15min, and thoroughly cleaning with deionized water. Dentin can be stored in 0.9% NaCl solution at (4. + -. 2). degree.C. for up to 3 weeks. The tooth desensitizer product of the invention was applied to the dry dentinal surface using a small brush for 30 seconds. Fixing all samples in 2.5% glutaraldehyde for 24 h, dehydrating, drying, spraying gold, observing the dentinal tubule sealing condition under a scanning electron microscope 1000, 1500, 2000, 2500 and 3000 times, taking a picture, and observing whether the test group has the dentinal tubule sealing effect or not by naked eyes; the test results are shown in table 4:
the sealing rate of the dentinal tubules in each example was measured by a scanning electron microscope, and the results are shown in table 4, and the sealing effect of each example was more than 90%; the occlusion effect of dentinal effect tends to increase with the increase in the amount of regenerative medical materials used in the product. The tooth desensitizer product olmingqing which is sold on the market at present is used as a comparative example, and the sealing effect is only about 70 percent. The product of the invention has obvious advantages compared with the product.
(4) Clinical efficacy testing for treating dentin hypersensitivity
The experimental method comprises the following steps: 60 patients with dentine hypersensitivity were randomly divided into 2 groups (example 5 and comparative-olmingqing), 30 per group; the sensitivity (i.e. pain level) was recorded by blowing cold vertically for 1s at 5mm from the buccal surface of the subject's sensitive teeth; the product 3g provided in example 5 and comparative example was applied to the sensitive tooth surface of the subject, and after holding for 3 min, the subject was rinsed and evaluated for sensitive areas of the teeth by blowing cold air vertically, and after the teeth were stimulated, the subject recorded sensitivity.
Sensitivity evaluation criteria: according to the evaluation standard of Shichuan Xiedi, 3 degrees of stimulation can induce intolerable pain; 2 degrees is stimulation can induce obvious pain, but can be tolerated; 1 degree is mild pain or discomfort which can be induced by stimulation; 0 degree is cold and mechanical stimulation without pain.
The evaluation standard of curative effect is as follows:
the 'significant effect' is that the difference value of the sensitivity before and after treatment is more than or equal to 2;
"effective" is a difference in sensitivity of 1 before and after treatment;
"ineffective" is a difference in sensitivity of 0 before and after treatment;
"worsening" is the difference in sensitivity before and after treatment is negative;
wherein the content of the first and second substances,
the significant efficiency (%) — significant number/total number of treatments × 100%;
effective rate (%) - (number of significant effect + number of effective effect)/total number of treatments × 100%.
The results are shown in table 5:
according to the test results, the sensitivity (namely the pain level) of a tooth desensitizer product provided by the embodiment 5 applied to a tooth anaphylaxis patient is remarkably reduced, the obvious effective rate reaches 86.67%, and the effective rate reaches 96.67%; none of the subjects had a recovery of pain level, i.e. no recovery after a reduction of pain level. The significant efficiency of the test sample provided by the comparative example is only 6.67%, and the effective rate is 70%. No side effects associated with the test product or the inventive product on the soft tissues of the oral cavity were found in the experiments.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (9)
1. The application of the regenerative medical material as a tooth desensitizing functional component in preparing a novel tooth desensitizer is characterized in that: the novel tooth desensitizer comprises the following components: the regenerative medical material, the matrix material, the dispersing agent, the gelling agent and other components, wherein the weight contents of the components are as follows:
1-40% of regenerative medical material, 10-50% of matrix material, 5-30% of dispersing agent, 0.1-5% of gelling agent and 0.1-40% of other components;
the regenerative medical material comprises the following components in percentage by weight: 12-38% SiO2，1-3%Na2O，1-3% K2O, 15-29%CaO, 1-32.5% P2O51-5% inositol hexaphosphate, 1-5% inositol phosphate;
the matrix material is selected from: one or more of glycerol, butanediol, polyethylene glycol, propylene glycol, hexanediol, polypropylene glycol and sorbitol.
2. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the weight contents of the components are as follows:
5-30% of regenerative medical material, 20-30% of matrix material, 10-20% of dispersing agent, 0.5-4.5% of gelling agent and 5-35% of other components.
3. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the particle size range of the regenerative medical material is 0.1-50 μm.
4. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 3 for preparing a novel tooth desensitizer, characterized in that: the particle size range of the regenerative medical material is 0.1-30 μm.
5. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the dispersant is selected from one or a mixture of more of alkyl glycoside, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, fatty acid polyglycol ester and sucrose ester.
6. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the gelling agent is one or a mixture of more of carbomer, guar gum, xanthan gum, gelatin, methylcellulose, sodium carboxymethylcellulose, sodium hydroxyethyl cellulose, hydroxypropyl methylcellulose and guar gum.
7. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the other ingredients are selected from one or more of thickening agent, flavoring agent and perfume, wherein the weight percentage of the thickening agent, the flavoring agent and the perfume in the tooth desensitizer is as follows:
5-30% of thickening agent, 0-5% of flavoring agent and 0.1-5% of perfume;
wherein the thickening agent is one or a mixture of more of fumed silica, bentonite or diatomite; the flavoring agent is selected from one or more of acesulfame potassium, saccharin sodium, aspartame, erythrose or xylitol; the perfume is selected from alcohol or terpenoid perfume, and the perfume comprises herba Menthae, flos Jasmini sambac, fructus Citri Limoniae, green tea or black tea.
8. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to claim 1 for preparing a novel tooth desensitizer, characterized in that: the novel tooth desensitizer is a paste gel or paste.
9. Use of the regenerative medical material as a tooth desensitizing effective ingredient according to any one of claims 1 to 8 in the preparation of a novel tooth desensitizer, characterized in that the preparation method of the novel tooth desensitizer specifically comprises the steps of:
adding a matrix material, a dispersing agent and a gelling agent into a high-speed shearing dispersion machine for dispersion, wherein the vacuum degree is-50 to-100 KPa, the shearing dispersion speed is 2000-10000 r/min, the dispersion time is 10 to 120min, and standing for 60 to 120min to obtain a mixture A;
breaking vacuum, adding the regenerated medical material and other components according to the formula, adding the regenerated medical material and other components into the mixture A for dispersing, wherein the vacuum degree is-50 to-100 KPa, the shearing and dispersing speed is 2000-10000 r/min, the dispersing time is 10 to 120min, and standing for 60 to 120min to obtain the tooth desensitizer product containing the regenerated medical material.
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| CN106421889A (en) * | 2016-08-24 | 2017-02-22 | 胡方 | Regenerative medical material and preparation method and application thereof |
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| CN104013539A (en) * | 2014-03-20 | 2014-09-03 | 胡方 | Preparation method of bone repair toothpaste agent inducing gene expression |
| CN105169458A (en) * | 2015-09-25 | 2015-12-23 | 胡方 | Biological activity mineral substance material and application of biological activity mineral substance material to soft tissue anabrosis and long-time erosion wound cell regeneration and melanoma restraining |
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