CN109738931B - Glomerular filtration rate check out test set - Google Patents
Glomerular filtration rate check out test set Download PDFInfo
- Publication number
- CN109738931B CN109738931B CN201811555397.5A CN201811555397A CN109738931B CN 109738931 B CN109738931 B CN 109738931B CN 201811555397 A CN201811555397 A CN 201811555397A CN 109738931 B CN109738931 B CN 109738931B
- Authority
- CN
- China
- Prior art keywords
- module
- barrel
- measuring
- radioactivity
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The invention discloses a glomerular filtration rate detection device which comprises a radioactivity activity measuring module and a control terminal module, wherein the radioactivity activity measuring module is used for measuring the radioactivity activity of a radioactive tracer and the radioactivity activity of a blood sample, the control terminal module is used for collecting basic information of a detected person and the radioactivity activity detected by the radioactivity activity measuring module, and the radioactivity activity measuring module is connected with the control terminal module. The system only needs to input basic information of a testee, automatically records activity and measuring time when measuring the activity of the radioactive tracer and the blood sample, and calculates the glomerular filtration rate by selecting a single plasma method, a double plasma method or a multiple plasma method according to the blood sampling times. The whole detection process reduces the times of manual recording and inputting, reduces the error probability and improves the working efficiency.
Description
Technical Field
The invention relates to detection equipment, in particular to glomerular filtration rate detection equipment.
Background
Glomerular Filtration Rate (GFR) is a well-known important index for evaluating renal function, is an important basis for stage division of chronic renal disease (CKD), and has important significance in clinically determining the dosage of a renal insufficiency patient, detecting the curative effect of renal disease, judging the disease progress, timely selecting renal replacement therapy and the like.
The determination of glomerular filtration rate using radionuclide assays, whether multi-plasma, dual-plasma or single-plasma, requires precise measurement of the amount of tracer injected into a subject (amount in syringe before injection-amount in syringe after injection), the amount of tracer in a blood sample. Since the radiotracer decays with time, the exact time of each measurement needs to be recorded for decay correction. In actual clinical work, there are two main methods for determining glomerular filtration rate using radionuclide assay: one uses gamma camera to measure the activity of radioactive tracer and blood sample, manual recording and calculation; one is to measure the activity of the radiotracer using an activity meter, the activity of the blood sample using a gamma counter, manually record and calculate the result.
The main problems of the prior art are as follows:
firstly, the method is complicated and easy to cause human errors. Measuring the glomerular filtration rate once, and recording the information of the subject at least including name, sex, age, height and weight; radiotracer information including injection time, pre-injection dose measurement time, post-injection dose measurement time; and sampling information including each blood sampling time, blood sample radioactivity, activity measurement time and the like. The above information is involved in the calculation of the final measurement result, and the record is required to be accurate and complete. In actual work, information recording and inputting errors are easy to occur and are not easy to find;
secondly, the work of measuring the radioactivity of the radioactive tracer and the blood sample can be carried out by different people, and the inconsistency of the measuring time can be caused by referring to different timers when the measuring time is recorded by different people;
in addition, when measuring the radioactivity, because the measuring range of the measuring equipment is limited, the equipment suitable for measuring the small dose cannot accurately measure the large dose of radioactivity, and the equipment suitable for measuring the large dose of radioactivity cannot accurately measure the small dose of radioactivity, and in the process of measuring the glomerular filtration rate, the difference of the radioactivity to be measured has 3 to 4 orders of magnitude, for example, when measuring the activity of a blood sample by using a gamma camera, the activity measuring error of the blood sample is often more than 10%.
Therefore, the prior art can not be fully used in actual clinical work, the product is incomplete, and the technical requirements on operators are high.
Disclosure of Invention
The present invention aims to provide a glomerular filtration rate detection apparatus to solve the problems set forth in the background art.
In order to achieve the purpose, the invention provides the following technical scheme:
a glomerular filtration rate detection device comprises a radioactivity measurement module and a control terminal module, wherein the radioactivity measurement module is used for measuring radioactivity of a radioactive tracer and a blood sample, the control terminal module is used for collecting basic information of a detected person and radioactivity detected by the radioactivity measurement module, and the radioactivity measurement module is connected with the control terminal module.
As a further technical scheme of the invention: the radioactivity activity measuring module comprises a shielding barrel, a well-type gamma counter, a small dose measuring barrel, a large dose measuring barrel and a ray filtering device, wherein the well-type gamma counter is installed at one end in the shielding barrel, an opening is formed in the shielding barrel at the position of a detector of the well-type gamma detector, the small dose measuring barrel is installed at the position of the opening, the large dose measuring barrel is installed at the other end of the shielding barrel, and the ray filtering device is installed in the shielding barrel and located between the large dose measuring barrel and the small dose measuring barrel.
As a further technical scheme of the invention: the ray filtering device consists of a filtering sheet, a motion controller and a linear guide rail, wherein the filtering sheet is arranged on the linear guide rail, and the linear guide rail is connected with the motion controller.
As a further technical scheme of the invention: the filter sheet is provided with a plurality of working areas, the thickness of each working area is different, but the thickness of at least one working area is 0, the thickness of the other working area is the full shielding thickness, and the full shielding thickness is the thickness for shielding more than 99% of rays.
As a further technical scheme of the invention: the control terminal module comprises a subject information acquisition module, an acquisition control module and a calculation module, wherein the subject information acquisition module is connected with the calculation module, the calculation module is connected with the subject information acquisition module, the acquisition control module is connected with the well type gamma counter and the motion controller, and the calculation module is connected with the subject information acquisition module and the acquisition control block.
Compared with the prior art, the invention has the beneficial effects that: 1. according to the invention, the measurement time is automatically recorded while the radioactivity of the sample is measured, and the result is automatically transmitted to the calculation module, so that the manual input and the human error are reduced; 2. the ray filtering device can realize automatic switching of filtering sheets with different thicknesses, enlarge the measuring range of radioactivity activity and ensure the measuring precision; 3. the calculation module of the invention automatically corrects the glomerular filtration rate according to the information of the age, sex, height, weight and the like of the testee, and can better meet the clinical requirements.
Drawings
Fig. 1 is a block diagram of a radioactivity measuring module.
Fig. 2 is a structural view of a ray filtering apparatus.
FIG. 3 is a block diagram of the logic of the glomerular filtration rate measurement device.
In the figure: 1-shielding barrel, 2-well type gamma counter, 3-ray filtering device, 4-large dose measuring barrel, 5-small dose measuring barrel, 6-optical filter and 7-linear guide rail.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-3, embodiment 1 provides a glomerular filtration rate measurement device including a radioactivity measuring module for measuring the radioactivity of a radioactive tracer and a blood sample;
and the control terminal module is used for acquiring basic information of the detected person and the radioactivity detected by the radioactivity activity measuring module and estimating the glomerular filtration rate of the detected person according to the received information.
Wherein, radioactivity activity measurement module includes: the device comprises a shielding barrel 1, a well type gamma counter 2, a ray filtering device 3, a large dose measuring barrel 4 and a small dose measuring barrel 5. The shielding barrel 1 is used for shielding the influence of external rays on the well type gamma counter and reducing the radiation of a sample to an operator in the measurement process. A well-type gamma counter 2 is arranged at one end in a shielding barrel 1, an opening is formed in the shielding barrel 1 at the position of a detector of the well-type gamma detector 2, a small-dose measuring barrel 5 is arranged at the position of the opening, and the small-dose measuring barrel 5 is used for measuring the radioactivity of a blood sample. The other end of the shielding barrel 1 is provided with a large dose measuring barrel 4, and the large dose measuring barrel 4 is used for measuring the activity of the radioactive tracer in the syringe before and after injection. In the shield barrel 1, between the large dose measuring barrel 4 and the small dose measuring barrel 3, a radiation filtering device 3 is installed. The ray filtering device 3 is composed of a filtering sheet 6, a linear guide rail 7 and a motion controller, wherein the filtering sheet 6 is provided with a plurality of working areas, the thickness of each working area is different, but the thickness of at least one working area is 0, and the thickness of the other working area is full shielding (namely the thickness capable of shielding more than 99% of rays). The filter sheet 6 is mounted on the linear guide rail 7, and the filter sheet 6 is translated by the motion controller, so that the filter thickness between the high-dose measuring barrel 4 and the well type gamma counter 2 is changed.
Example 2: on the basis of the embodiment 1, the control terminal module of the design comprises a subject information acquisition module, an acquisition control module and a calculation module. The subject information acquisition module is used for acquiring subject information; the acquisition control module is connected with the well-type gamma counter and the motion controller, controls the motion controller to realize the switching of different filtering thicknesses, and controls the well-type gamma counter 2 to acquire data to obtain the activity of the tested sample; the calculation module is connected with the subject information acquisition module and the acquisition control block and calculates the glomerular filtration rate of the patient according to the subject information and the activity of the sample.
The working process of the invention is as follows: 1. inputting the identification (name or ID), sex, birth date, height, weight and other information of the testee in the testee information acquisition module;
2. before a subject injects a tracer, an injector filled with the tracer is placed in a large-dose measuring barrel 4, an acquisition control module sends an instruction to control a well type gamma counter 2 to start acquiring data, the required filtering thickness is confirmed according to the acquired result, and then the instruction is sent to a ray filtering device 5 to be switched to the proper filtering thickness;
3. the acquisition controller acquires the activity of the tracer according to fixed time, and sends the measured activity value and acquisition time to the calculation module;
4. injecting tracer to the subject, and inputting injection time in the subject information module;
5. placing the injected injector into a large-dose measuring barrel 4, collecting the activity of the tracer agent remained in the empty injector by the same method as 2, and sending the activity value and the collection time to a calculation module;
6. according to clinical requirements, one or more times of blood samples are extracted at regular time, a detection blood sample is obtained after proper processing, and blood extraction time is input in a subject information acquisition module;
7. the detection blood samples are sequentially placed into a small-dose measuring barrel 3, the acquisition control module sends an instruction to a ray filtering device 5, a filter sheet 6 is switched to be fully shielded, the acquisition control module sends an instruction to control a well-type gamma counter 2 to acquire the activity of the detection blood samples, and an acquisition result and measurement time are sent to a calculation module;
8. the calculation module calculates the glomerular filtration rate according to the detection result and corrects according to the age, sex, height and weight of the subject.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (1)
1. A glomerular filtration rate detection device is characterized by comprising a radioactivity activity measuring module for measuring radioactivity of a radioactive tracer and a blood sample and a control terminal module for collecting basic information of a detected person and radioactivity detected by the radioactivity activity measuring module, wherein the radioactivity activity measuring module is connected with the control terminal module and comprises a shielding barrel, a well-type gamma counter, a small dose measuring barrel, a large dose measuring barrel and a ray filtering device, the well-type gamma counter is installed at one end in the shielding barrel, an opening is formed in the shielding barrel at the detector position of the well-type gamma detector, the small dose measuring barrel is installed at the opening position, the large dose measuring barrel is installed at the other end of the shielding barrel, the ray filtering device is installed in the shielding barrel and is positioned between the large dose measuring barrel and the small dose measuring barrel, the ray filtering device consists of a filtering sheet, a motion controller and a linear guide rail, the filtering sheet is arranged on the linear guide rail, the linear guide rail is connected with the motion controller, the filtering sheet is provided with a plurality of working areas, the thickness of each working area is different, but at least one active area has a thickness of 0 and the other active area has a thickness of the full shield thickness, the full-shielding thickness is the thickness for shielding more than 99% of rays, the control terminal module comprises a subject information acquisition module, an acquisition control module and a calculation module, the subject information acquisition module is connected with the calculation module, the calculation module is connected with the subject information acquisition module, the acquisition control module is connected with the well type gamma counter and the motion controller, the calculation module is connected with the subject information acquisition module and the acquisition control block, and the subject information acquisition module is used for acquiring the information of a subject; the acquisition control module is connected with the well-type gamma counter and the motion controller, controls the motion controller to realize the switching of different filtering thicknesses, and controls the well-type gamma counter to acquire data to obtain the activity of the tested sample; the calculation module is connected with the subject information acquisition module and the acquisition control block, and calculates the glomerular filtration rate of the patient according to the subject information and the activity of the sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555397.5A CN109738931B (en) | 2018-12-18 | 2018-12-18 | Glomerular filtration rate check out test set |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555397.5A CN109738931B (en) | 2018-12-18 | 2018-12-18 | Glomerular filtration rate check out test set |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109738931A CN109738931A (en) | 2019-05-10 |
| CN109738931B true CN109738931B (en) | 2022-06-17 |
Family
ID=66360631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811555397.5A Active CN109738931B (en) | 2018-12-18 | 2018-12-18 | Glomerular filtration rate check out test set |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109738931B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940797A (en) * | 2010-09-06 | 2011-01-12 | 四川大学华西医院 | Cladded nuclide labeled protein microsphere, preparation method and applications thereof |
| EP2471557A1 (en) * | 2010-12-27 | 2012-07-04 | Università degli Studi di Genova | A conjugate of human albumin and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid useful for the localization of radionuclides for diagnostic and therapeutic purposes |
| CN103189745A (en) * | 2010-09-24 | 2013-07-03 | 匹兹堡大学高等教育联邦体系 | Biomarkers of renal injury |
| CN104537267A (en) * | 2015-01-16 | 2015-04-22 | 广东省人民医院 | Evaluating system for glomerular filtration rate |
| CN105277723A (en) * | 2015-11-26 | 2016-01-27 | 北京大学第一医院 | Detecting system for glomerular filtration rate |
| CN106108932A (en) * | 2016-07-21 | 2016-11-16 | 四川大学 | Full-automatic kidney region of interest extraction element and method |
| CN107462915A (en) * | 2017-04-07 | 2017-12-12 | 中国人民解放军北京军区疾病预防控制中心 | A kind of real-time measuring method of radiopharmaceutical activity and system |
| CN108646281A (en) * | 2018-08-07 | 2018-10-12 | 福州智元仪器设备有限公司 | A kind of radiation patient isotope activity meter |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2854329B1 (en) * | 2003-04-29 | 2005-09-02 | Assist Publ Hopitaux De Paris | USE OF AN ANGIOTENSIN I CONVERTING ENZYME-RESISTANT TETRAPEPTIDE TETRAPEPTIDE ANALOGUE FOR MEASURING GLOMERULAR FILTRATION RATE IN MAN OR ANIMAL AND KIT CONTAINING SAME |
| JP5312752B2 (en) * | 2007-03-30 | 2013-10-09 | 富士フイルムＲｉファーマ株式会社 | Estimation program, recording medium, and estimation method |
| WO2011004273A2 (en) * | 2009-07-07 | 2011-01-13 | Koninklijke Philips Electronics N.V. | Dynamic pet imaging with isotope contamination compensation |
| KR101517072B1 (en) * | 2014-10-08 | 2015-05-04 | 이의호 | Method to measure glomerular filtration rate of the kidney and device thereof |
| CN105943070A (en) * | 2016-05-24 | 2016-09-21 | 深圳先进技术研究院 | PET system and imaging method thereof |
| CN108717200A (en) * | 2018-05-25 | 2018-10-30 | 长安大学 | A kind of radioactive sample activity multichannel automatic measuring system |
-
2018
- 2018-12-18 CN CN201811555397.5A patent/CN109738931B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940797A (en) * | 2010-09-06 | 2011-01-12 | 四川大学华西医院 | Cladded nuclide labeled protein microsphere, preparation method and applications thereof |
| CN103189745A (en) * | 2010-09-24 | 2013-07-03 | 匹兹堡大学高等教育联邦体系 | Biomarkers of renal injury |
| EP2471557A1 (en) * | 2010-12-27 | 2012-07-04 | Università degli Studi di Genova | A conjugate of human albumin and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid useful for the localization of radionuclides for diagnostic and therapeutic purposes |
| CN104537267A (en) * | 2015-01-16 | 2015-04-22 | 广东省人民医院 | Evaluating system for glomerular filtration rate |
| CN105277723A (en) * | 2015-11-26 | 2016-01-27 | 北京大学第一医院 | Detecting system for glomerular filtration rate |
| CN106108932A (en) * | 2016-07-21 | 2016-11-16 | 四川大学 | Full-automatic kidney region of interest extraction element and method |
| CN107462915A (en) * | 2017-04-07 | 2017-12-12 | 中国人民解放军北京军区疾病预防控制中心 | A kind of real-time measuring method of radiopharmaceutical activity and system |
| CN108646281A (en) * | 2018-08-07 | 2018-10-12 | 福州智元仪器设备有限公司 | A kind of radiation patient isotope activity meter |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109738931A (en) | 2019-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103260521B (en) | For the workflow of the integration of input function estimation accurately | |
| Lecchi et al. | Validation of a new protocol for 18 F-FDG infusion using an automatic combined dispenser and injector system | |
| DE112012004888T5 (en) | Systems and methods for transmitting dose calibration information | |
| Fawdry et al. | Comparative assessment of techniques for estimation of glomerular filtration rate with 99m Tc-DTPA | |
| Curtis et al. | Estimation of human calcium absorption by external radioisotope counting | |
| CN102472824A (en) | Dynamic pet imaging with isotope contamination compensation | |
| HURLEY et al. | A computerized system for rapid evaluation of thyroid function | |
| US7191109B2 (en) | Positron emission tomograph apparatus | |
| Lammertsma et al. | The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water | |
| MAISEY et al. | Validation of a rapid computerized method of measuring 99mTc pertechnetate uptake for routine assessment of thyroid structure and function | |
| EP2763590B1 (en) | Automated total body albumin analyzer | |
| CN109738931B (en) | Glomerular filtration rate check out test set | |
| Arnold et al. | The influence of true counting rate and the photopeak fraction of detected events on Anger camera deadtime | |
| Roselli et al. | Analysis of noninvasive macromolecular transport measurements in the lung | |
| CN104597472B (en) | The assay method of wound radioactive pollution depth, nucleic species and activity | |
| Williams et al. | Measurement of red cell destruction in the spleen | |
| Eriksson et al. | Characteristics of a new automated blood sampling system for positron emission tomography | |
| Baeza et al. | Calibration of an air monitor prototype for a radiation surveillance network based on gamma spectrometry | |
| CN210181232U (en) | SPECT counting rate characteristic and uniformity measuring device | |
| Bartolini et al. | Results of a thyroid monitoring survey carried out on workers exposed to 125I in São Paulo, Brazil | |
| KR101524454B1 (en) | A Device and Method for measuring Activity concentrations of Radon decay products | |
| CN115436987B (en) | Gamma-beta joint monitoring system and method for I-131 in air | |
| Meldolesi et al. | The renal plasma flow and glomerular filtration rate as estimated through double radiocompound renography | |
| Tandon et al. | Quality Assurance in Positron Emission Tomography-Computed Tomography (PET-CT) | |
| Esser et al. | Small computer assisted analysis of camera renograms |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220526 Address after: 201713 room 3084, building 4, No. 1-14, Lane 388, KANGYE Road, Zhujiajiao Town, Qingpu District, Shanghai Applicant after: Shanghai ruipaiyier Technology Co.,Ltd. Address before: Room 101, building 9, Zhejiang Euramerican Biotechnology Industrial Park, No. 501, Changsheng South Road, Jiaxing, Zhejiang 314000 Applicant before: ZHEJIANG RUIPAI MEDICAL TECHNOLOGY Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |