CN109731206A - A kind of sacculus for biological body vessel bifurcated lesions and application thereof and operation method - Google Patents
A kind of sacculus for biological body vessel bifurcated lesions and application thereof and operation method Download PDFInfo
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- CN109731206A CN109731206A CN201811539049.9A CN201811539049A CN109731206A CN 109731206 A CN109731206 A CN 109731206A CN 201811539049 A CN201811539049 A CN 201811539049A CN 109731206 A CN109731206 A CN 109731206A
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Abstract
The present invention relates to field of medical technology, it is related to a kind of sacculus for biological body vessel bifurcated lesions and application thereof and operation method, the in particular to sacculus of human vas bifurcated lesions and its application.The sacculus includes the first sacculus and the second sacculus of split settings.Implement load medicine ball capsule of the invention and has the advantage that bigger effect can be played in diseased region by 1. carrying medicine ball capsule, 2. two load medicine ball capsules are respectively placed in two branch vessels while carrying out expansion and are achieved in the complicated bifurcated lesions for the treatment of, simplify the realization of surgical procedure significantly 3. being equipped with corresponding accessory transformation, and improves the prognosis of disease treatment.
Description
Technical field
The present invention relates to field of medical technology, and in particular to a kind of for treating the ball of biological body vessel bifurcated lesions
Capsule, in particular to sacculus for the treatment of human vas bifurcated lesions and application thereof and operation method.
Background technique
In organism, especially lumens such as the intracorporal blood vessel of people, respiratory tract, alimentary canal, ear canal, nasal cavity exist a large amount of
Branch line, but due to the special air-flow and liquid flow characteristics of branch, such branch is the district occurred frequently of all kinds of obstructions and infection
Domain.It is one of the therapeutic modality quickly grown at present using the interventional therapy of bracket or sacculus.
Bifurcation coronary artery accounts for about the 20-30% in Coronary Artery Disease Intervention Treatment field, is common clinical problem, simultaneously
It is also most challenging one of the lesion in percutaneous coronary intervention field.The treatment operation difficulty of bifurcation coronary artery
Greatly, success rate of operation is low, and complication rate is high, and long-term effect is poor.
Medicine-coated balloon is a kind of intervention therapeutic apparatus, using sacculus as anti-cell proliferation agents carrier, passes through sacculus
Anti-proliferative drugs are discharged to coronary blood tube wall when expansion, to play the effect for inhibiting blood vessel endothelium hyperplasia.
Coronary artery stent implantation is the mainstream therapeutic modality of current treatment bifurcation coronary artery.Such as
Percutaneous coronary intervention for coronary bifurcation disease:11th
consensus document from the European Bifurcation Club(Eurolntervention;2016,
) and Contemporary Approach to Coronary Bifurcation Lesion Treatment Vol12:38-46
(JACC:Cardiovascular Interventions;2016, Vol9:1861-78) etc. coronary artery is disclosed in articles
The operating method of Stent reached common understanding.
In fact, the operation diagnosis and treatment of the stenter to implant in bifurcated lesions coronarius, presently, there are time-consuming, step is numerous
Trivial situation needs refigure shape in the blood vessels and, time on urgent, sky adherent with blood vessel to the bracket being implanted into advance
Between it is upper narrow, there is in the recent period and uncertainty in Long term therapy.
In the treatment of bifurcation coronary artery, proximal end optimisation technique (Proximal Optimal Technique,
POT) be it is a kind of after stenter to implant in the treatment means of bifurcated proximal row balloon expandable.The advantages of POT is operated is that bracket is close
Shaping is held, branch openings are charged into and covered to utmostly main branch bracket mesh, guarantees that bracket is adherent.POT technical essential: it 1. selects
Non-compliance sacculus;2. Balloon size will be more than bracket ruler diameter;3. positioning.The concordant branch openings lower edge of balloon distal is horizontal, closely
End does not get higher than bracket;4. sacculus is expanded with middle pressure.The surgical procedure of proximal end optimisation technique needs operative doctor in sacculus
It is more that above frequent switching, complex steps, uncontrollable factor are operated with bracket.
The treatment means that another kind uses in the prior art are that side branch patch actively shifts single-side stand technology (Active
Transfer of Plaque, ATP), the specific steps are that: 1. main branch and branch respectively enter the 2. preset bracket of main branch of seal wire,
Branch is placed in sacculus, and expanding (sacculus waist disappearance+1atm) makes patch be transferred to main branch.3. main branch under bifurcated balloon expansion state
Bracket is to name pressure 4. bifurcated balloon negative pressure of release, main branch bracket sacculus negative pressure;5. exit bifurcated balloon, it can retain or withdraw from point
Branch seal wire;6. main branch bracket sacculus is expanded again, guarantee the adherent of bracket.The existing single-side stand art formula of ATP art formula is easy to operate
Advantage, and have both the unobstructed advantage of double bracket art Shi Bianzhi simultaneously.Equally, the surgical procedure of ATP art formula needs operative doctor to exist
In sacculus and support operation, frequent switching, complex steps, uncontrollable factor is more.
Especially as to the most common Stent of vascular bifurcation lesions treatment, the biggest problems are that, Implantation Time
Long, complex steps require high, implantation of the simplest single-side stand to bifurcated lesions blood vessel to the operational capacity of operative doctor,
With regard to needing eight or more operating procedures.
At the same time, bare ball capsule (non-load medicine ball capsule) technology includes: in coronary artery bifurcated lesions technical difficult points
1. the bifurcated lesions of pair plaque load weight carry out single balloon angioplasty, bifurcated lesions are drawn by patch displacement
The branch vessel risen, which is involved, may cause interventional procedure center myocardial ischemia, after blood vessel balloon expandable, if without bracket
Support or anti-proliferative drugs locally discharge, then there may be the restenosis of very big probability.
2. when need two sacculus bifurcated lesions main branch vessel and branch vessel simultaneously expanded when how as early as possible
Make two sacculus tail end alignment, and avoids balloon expandable caused by human factor as far as possible during balloon expandable process or shrink not
It is synchronous.
3. the high recurrence rate of reangiostenosis and thrombus.
It is positive by being played for the therapeutic effect for improving bifurcation coronary artery if can solve the above problem
Effect.
Bibliography Percutaneous coronary intervention forcoronary bifurcation
Disease:11th consensus documentfrom the European Bi furcation Club
(Eurolntervention;2016, Vol12:38-46) and Contemporary Approach to Coronary
Bifurcation Lesion Treatment (JACC:Cardiovascular Interventions;2016, Vol9:
Figure in 1861-78) is used equally for illustrating background technique of the invention.
Summary of the invention
The present invention is to solve deficiency in the prior art, provides following technical scheme.
The purpose of the present invention is to provide a kind of sacculus for biological body vessel bifurcated lesions, the sacculus includes point
Body setting, and successively it is sequentially sent to the first sacculus and the second sacculus of blood vessel;First balloon interior is provided with tubulose
First inner chamber, second balloon interior are provided with the second inner chamber of tubulose;First seal wire is used to guide first sacculus, the
Two seal wires are for guiding second sacculus.
Further, first sacculus and the second sacculus at least one to carry medicine ball capsule.
Further, the load medicine ball capsule uses hydrophobic coating, hydrophilic coating, water-insoluble medicine coating or half hydrophobic painting
One of layer or a variety of method painting medicines.
Further, the surface of first sacculus and/or the second sacculus, which has, carries medicine structure, and the load medicine structure is ring
Tortuous gully structure, the rectangular recess structure, toroidal cavity structure being arranged around first sacculus and/or the second balloon surface
At least one of.
Further, the drug for carrying the load of medicine ball capsule is selected from taxol, rapamycin, rapamycin derivative, two
Methoxyl group canthin-6-one, Docetaxel, Doxorubicin, daunomycin, epirubicin, erythromycin, Estramustine, support
Moor glycosides, everolimus, Filgrastim, fluorine Bai Siting, Fluvastatin, fludarabine, fludarabine -5 '-dihydric phosphate, fluorine urine
Pyrimidine, folimycin, Fosfestrol, gemcitabine, Jia Lajina glycosides, ginkgol, ginkgoic acid, idarubicin, ifosfamide, friendship
It is arenomycin, lapachol, lomustine, Lovastatin, melphalan, medecamycin, mitoxantrone, Nimustine, Pitavastatin, general
Cut down statin, procarbazine, mitomycin, amethopterin, mercaptopurine, thioguanine, oxaliplatin, Irinotecan, topotecan,
Hydroxycarbamide, Miltefosine, Pentostatin, Pegaspargase, Exemestane, thunder song azoles, formestane, mycophenolate, β-lapachol, ghost
Mortar toxin, peg-interferon α-2b, polyethylene glycol, cytokine antagonist, basic element of cell division inhibitor, cyclooxygenase-2
Inhibitor, angiopeptin, the monoclonal antibody for inhibiting muscle cell multiplication, bFGF antagonist, probucol, prostaglandin, 1- hydroxyl
Base -11- methoxyl group canthin-6-one, Scopoletin, nitric oxide donors, pentaerythritol tetranitrate and sydnone imines, he
Not former times sweet smell, staurosporin, beta estradiol, alpha-estradiol, estriol, oestrone, ethinyloestradiol, Medroxyprogesterone, cyclopentyl propionic acid female two
Alcohol, oestradiol benzoate, tranilast, rabdosiaexcisa C prime and other for the terpenoid of cancer therapy, Verapamil, junket ammonia
Acid kinase inhibitor, 6- Alpha-hydroxy-taxol, taxotere, albumin mating type taxol, Mofebutazone, lonazolac, benefit
Cacaine, Ketoprofen, mefenamic acid, piroxicam, Meloxicam, penicillamine, hydroxychloroquine, sodium aurothiomalate, Oxaceprol, β-
Sitosterol, myrtecaine, polidocanol, Nonivamide, Levomenthol, ellipticine, demecolcine, B cytochalasin B A-E, print
Dan Nuoxin, nocodazole, bacitracin, vitronectin receptor antagonist, azelastine, guanylate cyclase stimulant, gold
The tissue depressant of Proteases -1 and metalloproteinases -2, free nucleic acid, the nucleic acid being incorporated in virus-spreader, deoxyribose
Nucleic acid and ribonucleic acid fragments, plasminogen activator inhibitor -1, plasminogen activator inhibitor -2, antisense widow's core
Thuja acid, vascular endothelial growth factor receptor inhibitors, insulin-like growth factor, the activating agent in antibiotic group, cephalo azanol benzyl,
Cefazolin, Cefaclor, cefotaxime, tobramycin, gentamicin, penicillin, dicloxacillin, oxacillin, sulfanilamide (SN), first
Nitre azoles, Enoxaparin, heparin, hirudin, D-Phe-Pro-arginine-chloromethane ketone, nucleoprotamine, prourokinase,
Streptokinase, warfarin, urokinase, vasodilator, Dipyridamole, trapidil, nitroprusside, blood platelet source growth factor
Antagonist, triazolo pyrimidine, salad be quick, acetylcholinesterase inhibitor, captopril, Cilazapril, lisinopril, Yi Napu
Benefit, Losartan, sulfoprotein enzyme inhibitor, prostacyclin, Vapiprost, interferon-' alpha ', interferon beta and interferon gamma, histamine are short of money
Anti-agent, thrombocytin blocking agent, apoptosis inhibitor, apoptosis regulation agent, Halofuginone, nifedipine, tocopherol, Qu Nisi
Spy, molsidomine, tea polyphenols, L-Epicatechin gallate, Epigallo-catechin gallate (EGCG), leflunomide, Yi Naxi
General, sulfasalazine, tetracycline, triamcinolone, mutamycin, procainamide, retinoic acid, quinindium, disopyramide, fluorine card
The steroids that Buddhist nun, Propafenone, Sotalol, natural and synthesis obtain, the toxin A that takes root, Inonotus obliquus alcohol, Ma Kuisang glycosides
A, Jia Lajina glycosides, Man Songning, streblus asper glycosides, hydrocortisone, betamethasone, dexamethasone, on-steroidal substance, Fei Nuoluo
Sweet smell, brufen, Indomethacin, naproxen, phenylbutazone, antivirotic, acyclovir, Ganciclovir, Zidovudine, clotrimazole,
Flucytosine, griseofulvin, ketoconazole, Miconazole, nystatin, Terbinafine, antiprotozoan agent, chloroquine, Mefloquine, quinine,
Natural terpenoid, hippocampus calcium albumen, 14- dehydrogenation root of Beijing euphorbia toxin, euphorbin, root of Beijing euphorbia toxin, 17- hydroxyl root of Beijing euphorbia toxin, in Indian Epimeredi Herb
Ester, 4,7- oxygroup ring anisomelic acid, class baccharine B1, B2, B3 and B7, rhizoma bolbostemmae glycosides, anti-dysentery yatanoside C, yatanoside N
With P, different deoxidation elephants-foot element, white flower elephants-foot element A and B, Jiang Huasu A, B, C and D, ursolic acid, Xipi his theobromine A, iso- Germany
Iris tectorum aldehyde, Variable-leaved Mayten alcohol, Rabdosia amethystoides penta element A, Amethystoidin A and Excisanin B, long tube plectranthin B, chrysanthemum scented tea
Dish C prime, Ka meter Bao element, Rui Jiluoer, triptolide, cymarin, protoanemonin, chlorination Che Libu element, very heavy rattan element A
With B, Dihydronitidine, Nitidine Chloride, pregnant diene -3, the 20- diketone of 12- beta-hydroxy, helenalin, indicine, big
Tail shake alkali-N- oxide, lasiocarpine, Inonotus obliquus alcohol, podophyllotoxin, justicidin A and B, La Ruiting, wild paulownia alkali,
Wild paulownia chromanol, isobutyryl open country paulownia chromanol, maytansine, the auspicious glad, Ma Jiting in Lake, water ghost any of several broadleaf plants alkali, liriodendrin, oxygen
It is precious to change micheline A, periplocin A, deoxidation psorospermin, nine section lignins, ricin A, sanguinarine, houseful wheat acid, methyl
Pearl antimellin, Rutaceae chromone, this replace Zuo Pulin, dihydro Wu Sabarenxin, hydroxyl usambarine, five amine of strychnic alkali, horse line
The general woods of sub- alkali, usambarine, Wu Sabarenxin, liriodendrin, daphnoretin, lariciresinol, methoxyl group lariciresinol, fourth
Face cream element, sirolimus, biolimus A9, Elidel, everolimus, azoles Luo Mosi, tacrolimus, albumin mating type
Sirolimus, Fasudil, Epothilones, growth hormone release inhibiting hormone, roxithromycin, troleandomycin, pungent cuts down him at nap- sirolimus
Spit of fland, vinblastine, vincristine, eldisine, Teniposide, Vinorelbine, Trofosfamide, Treosulfan, is replaced rosuvastatin
Muzolimine, phosphinothioylidynetrisaziridine, vitamin A acid, spiramvcin, umbelliferone, deacetylation dimension department rice grain pattern A, dimension department rice grain pattern A and B, Ze Wo
One of terpene is a variety of.
Further, first sacculus and the second sacculus are connect with control valve or triple valve respectively, and the control valve is remote
One end from first sacculus and the second sacculus is connected with perfusion liquid delivery pump, and the control valve can be controlled separately
Make the perfusion of first sacculus and the second sacculus.
Further, the control valve includes three position four-way directional control valve and triple valve, and the three position four-way directional control valve has
First port, second port, third port and the 4th port, the first port are connect with the first sacculus port, and described second
Port is connect with the second sacculus port, and the triple valve first port of the triple valve connects the third port, the triple valve
Triple valve second port pass through the first access port and the second access port and first sacculus port and the second sacculus end respectively
Mouth connection.
Further, the perfusion liquid delivery pump includes the first syringe and the second syringe, first syringe
The three position four-way directional control valve is connected, the triple valve first port connects third port, the first port and described first
The connection of sacculus port, second syringe are directly connect with the 4th port, the second port and second sacculus port
Connection, the triple valve second port pass through the first access port and the second access port and the first sacculus port and the second sacculus respectively
Port is connected.
Further, it is used to calculate balloon expandable or contraction time equipped with timer on the control valve of the sacculus.
Further, pipeline on or off can be manipulated, to set in advance equipped with timer on the control valve of the sacculus
Determine balloon expandable or contraction.
Further, balloon expandable or contraction time be can recorde equipped with timer on the control valve of the sacculus.
Further, record terminal can be transmitted data to equipped with timer on the control valve of the sacculus.It is transferred to
The data of terminal can directly generate case notes, and be checked by doctor.
Further, on the control valve of the sacculus equipped with timer, be provided with chip and can with mobile phone etc. other
Computing terminal is associated with using App or other programs.
Further, the sacculus has the channel of blood flow across sacculus, it is meant that and the expansion time for carrying medicine ball capsule is longer,
Drug is more complete in vascular wall release, and the pre-expansion of blood vessel and drug release are merged into once-through operation, for controlling for bifurcated lesions
Treatment provides faster and better clinical path.
The inside of above-mentioned sacculus, first sacculus and the second sacculus is respectively arranged with the positioning region that quantity is several
Part, these positioning elements are to provide positioning for operative doctor and guide, or locellus sacculus is filled in angiography
It is full of and guide is provided.
Above-mentioned sacculus, the positioning element is using any one in magnetic material, elemental metals material, alloy material
Or it a variety of is made.
Another object of the present invention is to provide purposes of the above-mentioned sacculus of one kind in treatment vascular bifurcation lesion.
A further object of the present invention is to provide the load medicine ball capsules of a kind of biological lumen interior orientation or positioning release to treat
Purposes in vascular bifurcation lesion.
Further, the vascular bifurcation lesion is bifurcation coronary artery or superior genicular artery vascular bifurcation lesion or knee
Lower arteries bifurcated lesions.
Further, the internal diameter coronarius is less than 7 millimeters, it is preferred that the internal diameter coronarius is less than 5 millis
Rice, it is furthermore preferred that the internal diameter coronarius is less than 4 millimeters, more it is furthermore preferred that the internal diameter coronarius is less than 3 millis
Rice.
Further, the load medicine ball capsule is using in hydrophobic coating, hydrophilic coating, non-water-soluble coating or half hydrophobic coating
One or more method painting medicines.
Further, the drug for carrying the load of medicine ball capsule is selected from taxol, rapamycin, rapamycin derivative, two
Methoxyl group canthin-6-one, Docetaxel, Doxorubicin, daunomycin, epirubicin, erythromycin, Estramustine, support
Moor glycosides, everolimus, Filgrastim, fluorine Bai Siting, Fluvastatin, fludarabine, fludarabine -5 '-dihydric phosphate, fluorine urine
Pyrimidine, folimycin, Fosfestrol, gemcitabine, Jia Lajina glycosides, ginkgol, ginkgoic acid, idarubicin, ifosfamide, friendship
It is arenomycin, lapachol, lomustine, Lovastatin, melphalan, medecamycin, mitoxantrone, Nimustine, Pitavastatin, general
Cut down statin, procarbazine, mitomycin, amethopterin, mercaptopurine, thioguanine, oxaliplatin, Irinotecan, topotecan,
Hydroxycarbamide, Miltefosine, Pentostatin, Pegaspargase, Exemestane, thunder song azoles, formestane, mycophenolate, β-lapachol, ghost
Mortar toxin, peg-interferon α-2b, polyethylene glycol, cytokine antagonist, basic element of cell division inhibitor, cyclooxygenase-2
Inhibitor, angiopeptin, the monoclonal antibody for inhibiting muscle cell multiplication, bFGF antagonist, probucol, prostaglandin, 1- hydroxyl
Base -11- methoxyl group canthin-6-one, Scopoletin, nitric oxide donors, pentaerythritol tetranitrate and sydnone imines, he
Not former times sweet smell, staurosporin, beta estradiol, alpha-estradiol, estriol, oestrone, ethinyloestradiol, Medroxyprogesterone, cyclopentyl propionic acid female two
Alcohol, oestradiol benzoate, tranilast, rabdosiaexcisa C prime and other for the terpenoid of cancer therapy, Verapamil, junket ammonia
Acid kinase inhibitor, 6- Alpha-hydroxy-taxol, taxotere, albumin mating type taxol, Mofebutazone, lonazolac, benefit
Cacaine, Ketoprofen, mefenamic acid, piroxicam, Meloxicam, penicillamine, hydroxychloroquine, sodium aurothiomalate, Oxaceprol, β-
Sitosterol, myrtecaine, polidocanol, Nonivamide, Levomenthol, ellipticine, demecolcine, B cytochalasin B A-E, print
Dan Nuoxin, nocodazole, bacitracin, vitronectin receptor antagonist, azelastine, guanylate cyclase stimulant, gold
The tissue depressant of Proteases -1 and metalloproteinases -2, free nucleic acid, the nucleic acid being incorporated in virus-spreader, deoxyribose
Nucleic acid and ribonucleic acid fragments, plasminogen activator inhibitor -1, plasminogen activator inhibitor -2, antisense widow's core
Thuja acid, vascular endothelial growth factor receptor inhibitors, insulin-like growth factor, the activating agent in antibiotic group, cephalo azanol benzyl,
Cefazolin, Cefaclor, cefotaxime, tobramycin, gentamicin, penicillin, dicloxacillin, oxacillin, sulfanilamide (SN), first
Nitre azoles, Enoxaparin, heparin, hirudin, D-Phe-Pro-arginine-chloromethane ketone, nucleoprotamine, prourokinase,
Streptokinase, warfarin, urokinase, vasodilator, Dipyridamole, trapidil, nitroprusside, blood platelet source growth factor
Antagonist, triazolo pyrimidine, salad be quick, acetylcholinesterase inhibitor, captopril, Cilazapril, lisinopril, Yi Napu
Benefit, Losartan, sulfoprotein enzyme inhibitor, prostacyclin, Vapiprost, interferon-' alpha ', interferon beta and interferon gamma, histamine are short of money
Anti-agent, thrombocytin blocking agent, apoptosis inhibitor, apoptosis regulation agent, Halofuginone, nifedipine, tocopherol, Qu Nisi
Spy, molsidomine, tea polyphenols, L-Epicatechin gallate, Epigallo-catechin gallate (EGCG), leflunomide, Yi Naxi
General, sulfasalazine, tetracycline, triamcinolone, mutamycin, procainamide, retinoic acid, quinindium, disopyramide, fluorine card
The steroids that Buddhist nun, Propafenone, Sotalol, natural and synthesis obtain, the toxin A that takes root, Inonotus obliquus alcohol, Ma Kuisang glycosides
A, Jia Lajina glycosides, Man Songning, streblus asper glycosides, hydrocortisone, betamethasone, dexamethasone, on-steroidal substance, Fei Nuoluo
Sweet smell, brufen, Indomethacin, naproxen, phenylbutazone, antivirotic, acyclovir, Ganciclovir, Zidovudine, clotrimazole,
Flucytosine, griseofulvin, ketoconazole, Miconazole, nystatin, Terbinafine, antiprotozoan agent, chloroquine, Mefloquine, quinine,
Natural terpenoid, hippocampus calcium albumen, 14- dehydrogenation root of Beijing euphorbia toxin, euphorbin, root of Beijing euphorbia toxin, 17- hydroxyl root of Beijing euphorbia toxin, in Indian Epimeredi Herb
Ester, 4,7- oxygroup ring anisomelic acid, class baccharine B1, B2, B3 and B7, rhizoma bolbostemmae glycosides, anti-dysentery yatanoside C, yatanoside N
With P, different deoxidation elephants-foot element, white flower elephants-foot element A and B, Jiang Huasu A, B, C and D, ursolic acid, Xipi his theobromine A, iso- Germany
Iris tectorum aldehyde, Variable-leaved Mayten alcohol, Rabdosia amethystoides penta element A, Amethystoidin A and Excisanin B, long tube plectranthin B, chrysanthemum scented tea
Dish C prime, Ka meter Bao element, Rui Jiluoer, triptolide, cymarin, protoanemonin, chlorination Che Libu element, very heavy rattan element A
With B, Dihydronitidine, Nitidine Chloride, pregnant diene -3, the 20- diketone of 12- beta-hydroxy, helenalin, indicine, big
Tail shake alkali-N- oxide, lasiocarpine, Inonotus obliquus alcohol, podophyllotoxin, justicidin A and B, La Ruiting, wild paulownia alkali,
Wild paulownia chromanol, isobutyryl open country paulownia chromanol, maytansine, the auspicious glad, Ma Jiting in Lake, water ghost any of several broadleaf plants alkali, liriodendrin, oxygen
It is precious to change micheline A, periplocin A, deoxidation psorospermin, nine section lignins, ricin A, sanguinarine, houseful wheat acid, methyl
Pearl antimellin, Rutaceae chromone, this replace Zuo Pulin, dihydro Wu Sabarenxin, hydroxyl usambarine, five amine of strychnic alkali, horse line
The general woods of sub- alkali, usambarine, Wu Sabarenxin, liriodendrin, daphnoretin, lariciresinol, methoxyl group lariciresinol, fourth
Face cream element, sirolimus, biolimus A9, Elidel, everolimus, azoles Luo Mosi, tacrolimus, albumin mating type
Sirolimus, Fasudil, Epothilones, growth hormone release inhibiting hormone, roxithromycin, troleandomycin, pungent cuts down him at nap- sirolimus
Spit of fland, vinblastine, vincristine, eldisine, Teniposide, Vinorelbine, Trofosfamide, Treosulfan, is replaced rosuvastatin
Muzolimine, phosphinothioylidynetrisaziridine, vitamin A acid, spiramvcin, umbelliferone, deacetylation dimension department rice grain pattern A, dimension department rice grain pattern A and B, Ze Wo
One of terpene is a variety of.
In the present invention, preferably refers in particular to shellac or shellac ammonium salt is that coating media, taxol or rapamycin and thunder pa are mould
Plain derivative is the load medicine ball capsule of drug.
Most preferred method refers to that shellac ammonium salt is coating media in the present invention, and taxol is the load medicine ball capsule of drug.
A further object of the present invention is to provide a kind of operation method of vascular bifurcation lesion, process is to vascular bifurcation
The advanced promoting circulation of blood pipe of lesion prepares;It connects and vascular bifurcation lesion is treated to kiss using sacculus, wherein at least one sacculus is to carry medicine ball
Capsule, preferably two sacculus are to carry medicine ball capsule.
Further, the preparation of blood vessel described in above-mentioned operation method includes and is not limited to, using bare ball capsule, cutting ball
The processing of the pre-expansions lesion vessels such as capsule, spinous process sacculus or indentation sacculus;Or using rotary polishing catheter or laser ablation conduit etc. to hat
Shape arterial disease carries out pretreatment preparation.
Further, bracket is not used during above-mentioned operation method.
Further, without using the branch for penetrating through or covering main branch vessel diseased region during above-mentioned operation method
Frame.
Further, the bracket of fixed vascular dissection can be used in the process final stage of above-mentioned operation method.
Further, above-mentioned operation method is using sacculus described in first invention purpose.
Further, the vascular bifurcation lesion of above-mentioned operation method is in coronary artery, and internal diameter is less than 7 millis
Rice, preferably less than 5 millimeters, preferred internal diameter is less than 4 millimeters, more it is furthermore preferred that the internal diameter coronarius is less than 3 millis
Rice.
A further object of the present invention is to provide a kind of operation method of vascular bifurcation lesion, process is to vascular bifurcation
Lesion first carries out diagnostic imaging;It connects and vascular bifurcation lesion is treated to kiss using sacculus, wherein at least one sacculus is to carry medicine ball
Capsule, preferably two sacculus are to carry medicine ball capsule.
Further, the diagnostic imaging includes but is not limited to angiography, nuclear-magnetism during above-mentioned operation method
One of resonance and photoacoustic imaging are a variety of.
Further, bracket is not used during above-mentioned operation method in surgical procedure, especially without using perforation
Or the bracket of the main branch vessel diseased region of covering.
Further, the bracket of fixed vascular dissection can be used in the process final stage of above-mentioned operation method.
Further, using sacculus described in first invention purpose during above-mentioned operation method.
Further, the vascular bifurcation lesion of above-mentioned operation method is in coronary artery, and internal diameter is less than 7 millis
Rice, preferably less than 5 millimeters, preferred internal diameter is less than 4 millimeters, more it is furthermore preferred that the internal diameter coronarius is less than 3 millis
Rice.
The present invention can add bracket according to vascular dissection situation after medicinal balloon is to kiss treatment, but can be to avoid
Penetrate through or cover the longer bracket of main branch vessel.
Load medicine ball capsule and bare ball capsule in the present invention can also use existing detention sacculus, Cutting balloon, spinous process sacculus
Or the technical solutions such as indentation sacculus are adjusted and improve.
Preferred method refers in particular to shellac in the present invention or shellac ammonium salt is coating media, taxol or rapamycin and thunder pa
Adm derivative is the load medicine ball capsule of drug.
It is using shellac ammonium salt as coating media, and using taxol as medicine that medicine ball capsule coating process is most preferably carried in the present invention
The load medicine ball capsule of object
Specific beneficial effect of the invention include: in the complicated bifurcated lesions for the treatment of two load medicine ball capsules be respectively placed in two
The expansion or contraction that branch branch vessel carries out simultaneously are achieved.
Also, the present invention allows by solving Partial key link therein and carries medicine ball capsule in coronary artery bifurcated
Prior effect is played in this clinical treatment difficult point of lesion.
Meanwhile load medicine ball capsule of the present invention, when conforming at target lesion, taxol drug small molecule can quickly lead to
Cross and passively diffuse into endothelial cell and subcutaneous compartment, play more rapidly longer inhibit target lesion at hyperblastosis with move
It moves, reaches more effective therapeutic effect.
In addition, comparing the stent endoprosthesis of traditional bifurcated lesions, the strategy of interventional therapy is carried out not using medicine ball capsule is carried
The operating process of operation is only simplified, while being placed in without foreign matter, the risk that thrombus occurs is reduced, mitigates foreign matter bring inflammatory
Reaction, and the duplex Antiplatelet therapy time of patient can be greatly shortened, mitigate patient's bleeding complication and financial burden.
Detailed description of the invention:
In order to illustrate the technical solution of the embodiments of the present invention more clearly, hereinafter by the attached drawing to the embodiment of the present invention into
Row is simple to be introduced.
Wherein, invention attached drawing is used only for showing some embodiments of the present invention, rather than by whole embodiments of the invention
Limited to this.
Fig. 1: the structural schematic diagram of sacculus described in the embodiment of the present invention.
Fig. 2: medicine ball capsule is carried to kiss schematic diagram.
Fig. 3: it carries medicine ball capsule and is coated with schematic diagram.
Fig. 4: dual cavity carries the intracapsular section chambers schematic diagram of medicine ball.
Fig. 5: three chambers carry the intracapsular section chambers schematic diagram of medicine ball.
Fig. 6: medicine balloon interior access schematic diagram is carried.
Fig. 7: the first schematic diagram of the control valve of the embodiment of the present invention.
Fig. 8: the diagrammatic cross-section of the control valve of the embodiment of the present invention.
Fig. 9: 1 coronary artery pathological changes schematic diagram of case.
Figure 10: 2 coronary artery pathological changes schematic diagram of case.
Figure 11: 3 coronary artery pathological changes schematic diagram of case.
Appended drawing reference:
First sacculus -1;Second sacculus -2;First inner chamber -3;Second inner chamber -4;First seal wire -5;Second seal wire -6;Control
Valve -7 processed;Liquid delivery pump -8 is perfused;Through inner tube -9;Multi-chamber sacculus -100;Sub-chamber -101;Branch -102 is perfused;The
One sub-chamber -101a;Second sub-chamber -101b;Third sub-chamber -101c;First perfusion branch -102a;Second perfusion branch-
102b;Branch -102c is perfused in third;Main road -103 is perfused;Carry medicine structure -104;First sacculus port -1010, the second sacculus end
Mouthfuls -2010, first port-A, second port-B, third port-P1, the 4th port-P2, three position four-way directional control valve -701, threeway
Valve -702, the first access port -703, the second access port -704, triple valve first port-V1, triple valve second port-V2, first
Syringe-D1, the second syringe-D2, H1- blood vessel endothelium, H2- bifurcated lesions patch.
Specific embodiment
In order to enable the purposes, technical schemes and advantages of technical solution of the present invention are clearer, below in conjunction with this
The technical solution of the embodiment of the present invention is clearly and completely described in the attached drawing of invention specific embodiment.
Identical appended drawing reference represents identical component in attached drawing.It should be noted that described embodiment is this hair
Bright a part of the embodiment, instead of all the embodiments.Based on described the embodiment of the present invention, ordinary skill
Personnel's every other embodiment obtained under the premise of being not necessarily to creative work, shall fall within the protection scope of the present invention.
Unless otherwise defined, the technical term or scientific term used herein should be in fields of the present invention and has
The ordinary meaning that the personage of general technical ability is understood.
" first ", " second " used in present patent application specification and claims and similar word
It is not offered as any sequence, quantity or importance, and is used only to distinguish different component parts.
Equally, the similar word such as "one" or " one " also not necessarily indicates quantity limitation." comprising " or "comprising" etc.
Similar word mean to occur element or object before the word cover the element for appearing in the word presented hereinafter or object and
It is equivalent, and is not excluded for other elements or object.
" connection " either the similar word such as " connected " is not limited to physics or mechanical connection, but can wrap
Electrical connection is included, it is either direct or indirect."upper", "lower", "left", "right" etc. are only used for indicating that relative position is closed
System, after the absolute position for being described object changes, then the relative positional relationship may also correspondingly change.
It should be noted that in the present invention carry medicine ball capsule using hydrophobic coating, hydrophilic coating, water-insoluble medicine coating or
One of half hydrophobic coating or a variety of method painting medicines.
Preferred method refers in particular to shellac in the present invention or shellac ammonium salt is coating media, taxol or rapamycin and thunder pa
Adm derivative is the load medicine ball capsule of drug.
Most preferred method refers to that shellac ammonium salt is coating media in the present invention, and taxol is the load medicine ball capsule of drug.
It is described the embodiment of the invention provides a kind of sacculus for biological body vessel bifurcated lesions referring to attached drawing 1-2
Sacculus includes split settings, and is successively sequentially sent to the first sacculus 1 and the second sacculus 2 of blood vessel;Inside first sacculus 1
It is provided with the first inner chamber 3 of tubulose, second sacculus 2 is internally provided with the second inner chamber 4 of tubulose;First seal wire 5 is for drawing
First sacculus 1 is led, the second seal wire 6 is for guiding second sacculus 2.
First sacculus 1 and the second sacculus 2 of the embodiment of the present invention bifurcated lesions patch H2 at skin H1 in the blood vessels
Treatment in, to prevent patch mobile and/or stent strut caused by SB folder close, the first seal wire 5 of bifurcated lesions and the second seal wire
Which branch's difficulty 6 entering orders follow substantially enters just to preferentially enter principle, reduces by second seal wire operational motion as far as possible, thus
Reduce the probability of two seal wires winding.Wherein, the position of bifurcated lesions patch H2 may be distributed on the surface blood vessel endothelium H1 or
It is distributed under the surface of blood vessel endothelium H1.
The proximal end of first sacculus 1 and the second sacculus 2 is respectively arranged with the positioning element that quantity is one, these positioning
Component is to provide positioning for operative doctor and guide, or the full offer guide of locellus sacculus in angiography.
The positioning element is made of any one or more in magnetic material, elemental metals material, alloy material.To kiss
Before, it can be by the positioning element, so that the tail end of first sacculus 1 and the second sacculus 2 is positioned.
In some embodiments of the invention, first sacculus 1 and the second sacculus 2 at least one to carry medicine ball capsule.
The load medicine ball capsule is using one of hydrophobic coating, hydrophilic coating or half hydrophobic coating or a variety of method painting medicines.Wherein,
The drug that half hydrophobic coating coating sacculus or water-insoluble medicine coating coating sacculus refer in particular to prepare due to specific coatings material applies
Layer sacculus, can make sacculus before reaching bifurcated lesions, can retain therapeutic agent and not be lost in body fluid or blood.
Referring to attached drawing 3, in some embodiments of the invention, the surface of first sacculus 1 and/or the second sacculus 2
With medicine structure 104 is carried, the medicine structure 104 that carries is the song being arranged around first sacculus 1 and/or 2 surface of the second sacculus
Roll at least one of gully structure, rectangular recess structure, toroidal cavity structure.
In some embodiments of the invention, it is preferred that use shellac or shellac ammonium salt for the load medicine ball capsule of matrix.
In some embodiments of the invention, first sacculus 1 and the second sacculus 2 are connect with control valve 7 respectively, institute
It states control valve 7 and is connected with perfusion liquid delivery pump 8, the control valve 7 far from one end of first sacculus 1 and the second sacculus 2
The perfusion of first sacculus 1 and the second sacculus 2 can separately or concurrently be controlled.
Referring to attached drawing 7, the embodiment of the invention provides a kind of typical control valves 7, using the control of the embodiment of the present invention
Valve 7 can not only separately or concurrently control first sacculus 1 and the perfusion of the second sacculus 2 can also be according to actual needs to
One sacculus 1 and the second sacculus 2 while pressurize expansion and decompression contraction.
It is specifically shown in attached drawing 7-8, control valve 7 includes three position four-way directional control valve 701, and there are four ports, respectively first for tool
Port A, second port B, third port P1, the 4th port P2, spool is respectively the first, second and third position there are three position is controlled.Its
In:
When spool is located at first position, third port P1 is connected with first port A, the 4th port P2 and second port B phase
Even;When spool is located at the second position, first port A, second port B, third port P1, the 4th port P2 are in cut-off shape
State;When spool is located at the third place, third port P1 is connected with second port B, and the 4th port P2 is connected with first port A.
It is specially the first syringe D1 and the second syringe D2 that liquid delivery pump 8, which is perfused, in the present embodiment, by this field
Technical staff it is well known that syringe can be used to sacculus pressurize, can also be used to decompression sacculus, under pressurised conditions its
It is used to using containing contrast fluid to the first sacculus 1 and/or the full expansion of the second sacculus 2.
First syringe D1 connection three position four-way directional control valve 701, the triple valve first port V1 of three position four-way directional control valve 701
First port P1 is connected, first port A is connect with the first sacculus port 1010, and the second syringe D2 directly connects with the 4th port P2
It connects, second port B is connect with the second sacculus port 2010, and the triple valve second port V2 of triple valve 702 passes through first respectively and connects
Entrance 703 and the second access port 704 and the first sacculus port 1010, the second sacculus port 2010 are connected.
Specifically used mode is as follows:
At bifurcated lesions, the first sacculus and the second sacculus are successively in place, if necessary to the first balloon expandable and the second ball
Capsule keeps unexpanded state, then triple valve 702 opens triple valve first port V1, the spool position of three position four-way directional control valve 701
In first position, first port A is connected to third port P1, and the first syringe D1 is only capable of to the first sacculus supply fluid at this time,
Second syringe D2 is not operated although being connected with the second sacculus;Keep current pressure constant if necessary to the first sacculus, then only
The spool of three position four-way directional control valve 701 need to be located at the second position, at this time first port A, second port B, third port P1, the
Four port P2 are disconnected;If necessary to by the second balloon expandable, then the spool of three position four-way directional control valve 701 is located at third position
It sets, the first syringe D1 is only capable of to the second sacculus supply fluid at this time, and the first sacculus is connected with the second syringe D2, selectable
It is that the second syringe D2 can depressurize the first sacculus at this time.
It needs the first sacculus and the second sacculus after if the first sacculus 1 and the second sacculus 2 are successively in place while expanding, and
The pressure of expansion is consistent, then the triple valve second port V2 admittance of triple valve 702, and the first syringe D1 is directly to the first ball at this time
2010 supply pressure of capsule port 1010 and the second sacculus port, it will be understood that can also simultaneously depressurize two sacculus.
Above-mentioned control valve 7 is the advantage is that controlled the first syringe D1 by the doctor to perform the operation, and 3-position 4-way is commanded to change
To 702 on-off flow path of valve 701 and triple valve, the abundant protrusion event that can preferably cope in operation of the doctors experience of operation,
And the support staff that performs the operation controls the second syringe D2, is only used for the second such simple operations of syringe D2 of decompression, therefore control valve 7
It being capable of all kinds of prominent events and emergency case in effective Ying Yushuan balloon operation.
It should be noted that control valve 7 of the present invention can also using other flow path reversal valves or valve it
Between combination in parallel or series, can be realized separately or concurrently control first sacculus and the second sacculus 2 and its respectively it is more
The expansion or contraction of chamber.
In some embodiments of the invention, first sacculus 1 and/or the second sacculus 2 are multi-chamber sacculus 100.
Include more than two mutually indepedent sub-chamber 101 for separating setting inside the multi-chamber sacculus 100, the sub-chamber 101 with
Branch 102 is perfused to be connected to, the perfusion branch 102 converges in one end of perfusion main road 103, described that the another of main road 103 is perfused
End is connect with the perfusion liquid delivery pump 8.
The embodiment of the invention also provides a kind of application method using sacculus treatment vascular bifurcation lesion, Yi Jiyi
Kind, in biological lumen interior orientation or positioning release, treats the application method of vascular bifurcation lesion using the load medicine ball capsule.
In addition, it is one or more positioning regions that the proximal end of first sacculus 1 and the second sacculus 2, which is respectively arranged with quantity,
Part, these positioning elements are to provide positioning for operative doctor and guide, or locellus sacculus is filled in angiography
It is full of and guide is provided.
The positioning element is made of any one or more in magnetic material, elemental metals material, alloy material.
It, can be by the positioning element, so that the tail end of first sacculus 1 and the second sacculus 2 is positioned before to kiss.
It is described cardiovascular for coronary artery in some embodiments of the invention.The coronary artery diameter is less than 7 millis
Rice, it is preferred that the coronary artery diameter is less than 5 millimeters, it is furthermore preferred that the coronary artery diameter is less than 4 millimeters, it is more excellent
Choosing, the internal diameter coronarius is less than 3 millimeters.
Embodiment 1
Referring to attached drawing 4, in the present embodiment, first sacculus 1 and/or the second sacculus 2 are multi-chamber sacculus 100.Institute
Stating inside multi-chamber sacculus 100 includes mutually indepedent the first sub-chamber 101a, the second sub-chamber 101b for separating setting.Described
One sub-chamber 101a, the second sub-chamber 101b are connected to the first perfusion branch 102a, the second perfusion branch 102b respectively;Described
One perfusion branch 102a, the second perfusion branch 102b converge in one end of perfusion main road 103 jointly, the perfusion main road 103
The other end is connect with the perfusion liquid delivery pump 8.
Embodiment 2
Referring to attached drawing 5, in the present embodiment, first sacculus 1 and/or the second sacculus 2 are multi-chamber sacculus 100.Institute
Stating inside multi-chamber sacculus 100 includes mutually indepedent the first sub-chamber 101a, the second sub-chamber 101b and the third for separating setting
Sub-chamber 101c.Branch is perfused with first respectively in the first sub-chamber 101a, the second sub-chamber 101b and third sub-chamber 101c
Road 102a, the second perfusion branch 102b are connected to third perfusion branch 102c;The first perfusion branch 102a, the second perfusion branch
Road 102b and third perfusion branch 102c jointly perfusion main road 103 one end converge, it is described perfusion main road 103 the other end with
The perfusion liquid delivery pump 8 connects.The tail of the first sub-chamber 101a, the second sub-chamber 101b and third sub-chamber 101c
End is overlapped;The head end of the second sub-chamber 101b and third sub-chamber 101c and the middle part of the first sub-chamber 101a are neat
It is flat;The second sub-chamber 101b and third sub-chamber 101c is located at the two sides of the first sub-chamber 101a;Described
One sub-chamber 101a has spindle shape and structure, and the second sub-chamber 101b and third sub-chamber 101c have described in semi-surrounding
The valvular structure of first sub-chamber 101a.
Embodiment 3
It in the present embodiment, inside first sacculus 1 and/or the second sacculus 2 further include through inner tube referring to attached drawing 6
9, it is described to run through 9 inner hollow of inner tube, the both ends external connection with first sacculus 1 and/or the second sacculus 2 respectively.
Embodiment 4
Referring to attached drawing 7-8, the embodiment of the invention provides a kind of control valves 7, using the perfusion liquid of the embodiment of the present invention
Delivery pump 8 and control valve 7 can not only separately control the perfusion of first sacculus 1 and the second sacculus 2.When described
It includes mutually indepedent point that one sacculus 1 and/or the second sacculus 2, which are inside multi-chamber sacculus 100, such as the multi-chamber sacculus 100,
When the first sub-chamber 101a, the second sub-chamber 101b and third sub-chamber 101c of setting, control provided in an embodiment of the present invention
Valve 7 processed can carry out essence independently to the first sub-chamber 101a, the second sub-chamber 101b and third sub-chamber 101c
Quasi- control.Therefore, during carrying out operative treatment using the sacculus of the embodiment of the present invention, an assistant couple can be used
2 multiple sub-chamber being successively sent into the sacculus and the sacculus of blood vessel are precisely controlled, that is, ensure that two institutes
It fills and discharges while stating sacculus, be also convenient for accurately controlling the shape of sacculus.
Case 1
Patient king * *, 56 years old male, admission diagnosis " coronary heart disease, unstable angina pectoris ", coronarography prompt " point
Lesion is pitched, descending anterior branch proximal segment 85% is narrow, and the 1st diagonal branch 80% is narrow ", vision estimates descending anterior branch proximal segment diameter 3.0mm, diagonally
Branch proximal segment diameter 2.75mm, as shown in Figure 9.
Prepare before routinely improving interventional therapy by percutaneous coronary intervention, is diameter 3.0mm by specification, length 20mm's
Medicine-coated balloon 1It is placed in descending anterior branch, is diameter 2.75mm by specification, the drug of length 20mm applies
Layer sacculus 2It is placed in diagonal branch, applies medicine-coated balloon 1 and drug by adjusting rapidly manually
Layer 2 positioning element of sacculus is aligned in descending anterior branch proximal segment, rapidly conveys two medicine-coated balloon ends and control valve 7 and liquid
8 connection of pump, is first adjusted to bilateral position for control valve 7, and liquid in liquid delivery pump 8 is injected to medicine-coated balloon 1 simultaneously
It is expanded with 12atm simultaneously with medicine-coated balloon 2, continues 45 seconds, and using liquid delivery pump 8, pumpback drug is applied simultaneously later
Liquid in layer sacculus 1 and medicine-coated balloon 2 both makes to bounce back to simultaneously and takes out flat state, checks radiography, descending anterior branch and diagonally
Branch TIMI3 grades of blood flow, has no clear vascular dissection, terminates operative treatment without obvious Detecting Residual Stenosis.
For about 30 minutes, postoperative 9 months follow-up patients checked coronary artery and make entire surgical procedure without colic pain of making up one's mind again
Shadow prompts descending anterior branch and diagonal branch without obvious blood vessel diameter restenosis.
Case 2
Patient Cai * *, 70 years old women, admission diagnosis " coronary heart disease, unstable angina pectoris ", coronarography prompt " point
Lesion is pitched, descending anterior branch proximal segment 50% is narrow, and the 1st diagonal branch ostium 90% is narrow ", vision estimates descending anterior branch proximal segment diameter 3.5mm,
Diagonal branch proximal segment diameter 2.5mm, as shown in Figure 10, ultrasound discovery descending anterior branch proximal segment minimum tube in further row coronary artery
Cavity area 3.5mm2。
Prepare before routinely improving interventional therapy by percutaneous coronary intervention, is diameter 3.5mm by specification, length 22mm's
Medicine-coated balloon 1It is placed in descending anterior branch, is diameter 2.5mm by specification, the drug of length 22mm applies
Layer sacculus 2 is placed in diagonal branch, makes medicine-coated balloon 1 by adjusting rapidly manually And medication coat
2 positioning element of sacculus is aligned in descending anterior branch proximal segment, rapidly by two medicine-coated balloon ends and control valve 7 and liquid delivery pump
8 connections, are first adjusted to bilateral position for control valve 7, and liquid in liquid delivery pump 8 is injected to 1 He of medicine-coated balloon simultaneously
Medicine-coated balloon 2 expands it with 12atm simultaneously, continues 45 seconds, later using liquid delivery pump 8 while pumpback medication coat
Liquid in sacculus 1 and medicine-coated balloon 2 makes the two while bouncing back to take out flat state, checks radiography, descending anterior branch and diagonal branch
Without obvious Detecting Residual Stenosis, TIMI3 grade of blood flow, ultrasound in coronary artery is checked, has no clear vascular dissection or intramural hematoma,
Descending anterior branch minimum Lumen Area 6.2mm2, diagonal branch minimum Lumen Area 4.4mm2, terminate operative treatment.
For about 45 minutes, postoperative 9 months follow-up patients checked coronary artery and make entire surgical procedure without colic pain of making up one's mind again
Shadow prompts descending anterior branch and diagonal branch without obvious blood vessel diameter restenosis.
Case 3
Patient Liu * *, 64 years old women, admission diagnosis " coronary heart disease, unstable angina pectoris ", coronarography prompt " point
Lesion is pitched, arteria coronaria dextra distal section 50% is narrow, and lesion is diffused to posterior descending branch proximal segment, and rear side branch ostium 90% is narrow ", vision is estimated
Survey arteria coronaria dextra distal section diameter 2.5mm, posterior descending branch proximal segment diameter 2.5mm, rear side branch proximal segment diameter 2.25mm, such as Figure 11 institute
Show.
Prepare before routinely improving interventional therapy by percutaneous coronary intervention, rear side branch is expanded by Cutting balloon and is carried out
Specification is diameter 2.5mm, the medicine-coated balloon 1 of length 22mm after evaluation meets predilation Success criteria by abundant predilation It is placed in arteria coronaria dextra-posterior descending branch, is diameter 2.25mm, the medication coat of length 22mm by specification
Sacculus 2It is placed in rear side branch, makes medicine-coated balloon 1 and medication coat ball by adjusting rapidly manually
2 positioning element of capsule is aligned in descending anterior branch proximal segment, rapidly by two medicine-coated balloon ends and control valve 7 and liquid delivery pump 8
Connection, is first adjusted to bilateral position for control valve 7, and liquid in liquid delivery pump 8 is injected to medicine-coated balloon 1 and medicine simultaneously
Object coating sacculus 2 expands it with 12atm simultaneously, continues 45 seconds, later using liquid delivery pump 8 while pumpback medication coat ball
Liquid in capsule 1 and medicine-coated balloon 2 makes the two while bouncing back to take out flat state, checks radiography, arteria coronaria dextra, rear drop
Branch and rear side branch TIMI3 grades of blood flow, have no clear vascular dissection, terminate operative treatment without obvious Detecting Residual Stenosis.
For about 35 minutes, postoperative 9 months follow-up patients checked coronary artery and make entire surgical procedure without colic pain of making up one's mind again
Shadow prompts arteria coronaria dextra, posterior descending branch and rear side branch without obvious blood vessel diameter restenosis.
It is described in detail exemplary embodiment of the invention above in reference to preferred embodiment and case, however ability
Field technique personnel can make above-mentioned specific embodiment a variety of it will be appreciated that under the premise of without departing substantially from theory of the present invention
Modification and remodeling, and multiple combinations can be carried out to various technical characteristics proposed by the present invention, structure, and without departing from of the invention
Protection scope.
Claims (13)
1. a kind of sacculus for biological body vessel bifurcated lesions, it is characterised in that: the sacculus includes split settings, and by
The first sacculus (1) and the second sacculus (2) being successively sequentially sent at bifurcated lesions;First sacculus (1) is internally provided with pipe
The first inner chamber (3) of shape, second sacculus (2) are internally provided with the second inner chamber (4) of tubulose;First seal wire (5) is for drawing
First sacculus (1) is led, the second seal wire (6) is for guiding second sacculus (2).
2. sacculus according to claim 1, it is characterised in that: first sacculus (1) and the second sacculus (2) at least one
To carry medicine ball capsule.
3. sacculus according to claim 2, it is characterised in that: the load medicine ball capsule is using hydrophobic coating, hydrophilic coating, non-
One of water soluble drug coating or half hydrophobic coating or a variety of method painting medicines.
4. sacculus described in any one of -3 according to claim 1, which is characterized in that first sacculus (1) and/or second
The surface of sacculus (2), which has, carries medicine structure (104), and the loads medicine structure (104) is circular first sacculus (1) and/or the
Tortuous gully structure, rectangular recess structure, at least one of the toroidal cavity structure of two sacculus (2) surface setting.
5. sacculus according to claim 4, it is characterised in that: the drug for carrying the load of medicine ball capsule is selected from taxol, thunder
The soft ratio of pa mycin, rapamycin derivative, dimethoxy canthin-6-one, Docetaxel, Doxorubicin, daunomycin, table
Star, erythromycin, Estramustine, Etoposide, everolimus, Filgrastim, fluorine Bai Siting, Fluvastatin, fludarabine, fluorine reach
Draw shore -5 '-dihydric phosphate, fluorouracil, folimycin, Fosfestrol, gemcitabine, Jia Lajina glycosides, ginkgol, ginkgo
Acid, idarubicin, ifosfamide, josamycin, lapachol, lomustine, Lovastatin, melphalan, medecamycin, meter Tuo
Anthraquinone, Nimustine, Pitavastatin, Pravastatin, procarbazine, mitomycin, amethopterin, mercaptopurine, thioguanine, Austria
Husky benefit platinum, Irinotecan, topotecan, hydroxycarbamide, Miltefosine, Pentostatin, Pegaspargase, Exemestane, thunder song azoles, good fortune
It is Mei Tan, mycophenolate, β-lapachol, podophyllotoxin, peg-interferon α-2b, polyethylene glycol, cytokine antagonist, thin
Born of the same parents' mitogen inhibitor, COX-2 inhibitors, angiopeptin, the monoclonal antibody for inhibiting muscle cell multiplication, bFGF antagonism
Agent, probucol, prostaglandin, 1- hydroxyl -11- methoxyl group canthin-6-one, Scopoletin, nitric oxide donors, Ji Wusi
Alcohol tetranitrate and sydnone imines, tamoxifen, staurosporin, beta estradiol, alpha-estradiol, estriol, oestrone, alkynes are female
Alcohol, Medroxyprogesterone, cycloprovera, oestradiol benzoate, tranilast, rabdosiaexcisa C prime and it is other be used for cancer
Terpenoid, Verapamil, tyrosine kinase inhibitor, 6- Alpha-hydroxy-taxol, taxotere, the albumin mating type Japanese yew of therapy
Alcohol, Mofebutazone, lonazolac, lidocaine, Ketoprofen, mefenamic acid, piroxicam, Meloxicam, penicillamine, hydroxy chloride
Quinoline, sodium aurothiomalate, Oxaceprol, cupreol, myrtecaine, polidocanol, Nonivamide, Levomenthol, ellipticine,
Demecolcine, B cytochalasin B A-E, Yin Dannuoxin, nocodazole, bacitracin, vitronectin receptor antagonist, nitrogen Zhuo Si
Spit of fland, guanylate cyclase stimulant, metalloproteinases -1 and metalloproteinases -2 tissue depressant, free nucleic acid, be incorporated to disease
Nucleic acid, DNA and ribonucleic acid fragments, plasminogen activator inhibitor -1, plasminogen in malicious disseminator
Activating factor inhibitors -2, antisense oligonucleotides, vascular endothelial growth factor receptor inhibitors, insulin-like growth factor, antibiotic
Activating agent, cephalo azanol benzyl in group, Cefazolin, Cefaclor, cefotaxime, tobramycin, gentamicin, mould
Element, dicloxacillin, oxacillin, sulfanilamide (SN), metronidazole, Enoxaparin, heparin, hirudin, D-Phe-Pro-essence ammonia
Acid-chloromethane ketone, nucleoprotamine, prourokinase, streptokinase, warfarin, urokinase, vasodilator, Dipyridamole, bent ground
That, nitroprusside, the growth factor antagonist in blood platelet source, triazolo pyrimidine, salad be quick, acetylcholinesterase inhibitor, card
Top's benefit, Cilazapril, lisinopril, enalapril, Losartan, sulfoprotein enzyme inhibitor, prostacyclin, Vapiprost,
Interferon-' alpha ', interferon beta and interferon gamma, histamine antagonist, thrombocytin blocking agent, apoptosis inhibitor, apoptosis regulation
Agent, Halofuginone, nifedipine, tocopherol, tranilast, molsidomine, tea polyphenols, L-Epicatechin gallate, epi-nutgall
Catechin and gallate, leflunomide, Etanercept, sulfasalazine, tetracycline, triamcinolone, mutamycin, Proca
Because of the steroids that amine, retinoic acid, quinindium, disopyramide, Flecainide, Propafenone, Sotalol, natural and synthesis obtain, fall
Ground is taken root toxin A, Inonotus obliquus alcohol, Ma Kuisang glycosides A, Jia Lajina glycosides, Man Songning, streblus asper glycosides, hydrocortisone, times his rice
Pine, dexamethasone, on-steroidal substance, fenoprofen, brufen, Indomethacin, naproxen, phenylbutazone, antivirotic, Ah former times
Luo Wei, Ganciclovir, Zidovudine, clotrimazole, Flucytosine, griseofulvin, ketoconazole, Miconazole, nystatin, spy compare naphthalene
Sweet smell, antiprotozoan agent, chloroquine, Mefloquine, quinine, natural terpenoid, hippocampus calcium albumen, 14- dehydrogenation root of Beijing euphorbia toxin, euphorbin, the root of Beijing euphorbia
Toxin, 17- hydroxyl root of Beijing euphorbia toxin, Indian Epimeredi Herb lactone, 4,7- oxygroup ring anisomelic acid, class baccharine B1, B2, B3 and B7, soil
Fritillaria glycosides, anti-dysentery yatanoside C, yatanoside N and P, different deoxidation elephants-foot element, white flower elephants-foot element A and B, Jiang Huasu A, B, C
With D, ursolic acid, Xipi his theobromine A, iso- Iris germanica aldehyde, Variable-leaved Mayten alcohol, Rabdosia amethystoides penta element A, Amethystoidin A and perfume (or spice)
Tea dish B prime, long tube plectranthin B, chrysanthemum Rabdosia amethystoides C prime, Ka meter Bao element, Rui Jiluoer, triptolide, cymarin, original
Anemonin, chlorination Che Libu element, very heavy rattan element A and B, Dihydronitidine, Nitidine Chloride, the pregnant diene-of 12- beta-hydroxy
3,20- diketone, helenalin, indicine, indicine-N- oxide, lasiocarpine, Inonotus obliquus alcohol, podophyllotoxin
Element, justicidin A and B, La Ruiting, wild paulownia alkali, wild paulownia chromanol, isobutyryl open country paulownia chromanol, maytansine, Lake are auspicious
Glad, Ma Jiting, water ghost any of several broadleaf plants alkali, liriodendrin, oxoushinsunine, periplocin A, deoxidation psorospermin, nine section lignins, castor-oil plant
Toxin A, sanguinarine, houseful wheat acid, methyl sorbifolin, Rutaceae chromone, this for Zuo Pulin, dihydro Wu Sabarenxin,
Hydroxyl usambarine, five amine of strychnic alkali, the general woods of strychnic alkali, usambarine, Wu Sabarenxin, liriodendrin, daphnoretin,
Lariciresinol, methoxyl group lariciresinol, syringaresinol, sirolimus, biolimus A9, Elidel, everolimus,
Azoles Luo Mosi, tacrolimus, albumin mating type sirolimus, nap- sirolimus, Fasudil, Epothilones, growth suppression
Element, troleandomycin, Simvastatin, rosuvastatin, vinblastine, vincristine, eldisine, replaces Ni Bo at roxithromycin
It is glycosides, Vinorelbine, Trofosfamide, Treosulfan, Temozolomide, phosphinothioylidynetrisaziridine, vitamin A acid, spiramvcin, umbelliferone, deacetylated
One of Ji Weisi rice grain pattern A, dimension department rice grain pattern A and B, zeorin or a variety of.
6. sacculus described in any one of -5 according to claim 1, it is characterised in that: first sacculus (1) and the second ball
Respectively with control valve (7), the control valve (7) connects with one end of the second sacculus (2) far from first sacculus (1) capsule (2)
Have perfusion liquid delivery pump (8), the control valve (7) can separately or concurrently control first sacculus (1) and the second sacculus
(2) perfusion.
7. sacculus according to claim 6, it is characterised in that: the control valve (7) is connected with timer.
8. purposes of the sacculus according to any one of claims 1-7 in treatment vascular bifurcation lesion.
9. biological lumen interior orientation or the medicine ball capsule that carries of positioning release are treating the purposes in vascular bifurcation lesion.
10. purposes according to claim 9, is characterized in that: the vascular bifurcation lesion be bifurcation coronary artery or
Superior genicular artery vascular bifurcation lesion or inferior genicular artery vascular bifurcation lesion.
11. purposes according to claim 10, it is characterised in that: the internal diameter coronarius is less than 7 millimeters, preferably
, the internal diameter coronarius is less than 5 millimeters, it is furthermore preferred that the internal diameter coronarius is less than 4 millimeters, more more preferably
, the internal diameter coronarius is less than 3 millimeters.
12. according to any purposes of right 9-11, it is characterised in that: the load medicine ball capsule uses hydrophobic coating, hydrophilic painting
One of layer, non-water-soluble coating or half hydrophobic coating or a variety of method painting medicines.
13. purposes according to claim 12, it is characterised in that: it is described carry medicine ball capsule load drug be selected from taxol,
Rapamycin, rapamycin derivative, dimethoxy canthin-6-one, Docetaxel, Doxorubicin, daunomycin, table are soft
Than star, erythromycin, Estramustine, Etoposide, everolimus, Filgrastim, fluorine Bai Siting, Fluvastatin, fludarabine, fluorine
Up to drawing shore -5 '-dihydric phosphate, fluorouracil, folimycin, Fosfestrol, gemcitabine, Jia Lajina glycosides, ginkgol, ginkgo
Acid, idarubicin, ifosfamide, josamycin, lapachol, lomustine, Lovastatin, melphalan, medecamycin, meter Tuo
Anthraquinone, Nimustine, Pitavastatin, Pravastatin, procarbazine, mitomycin, amethopterin, mercaptopurine, thioguanine, Austria
Husky benefit platinum, Irinotecan, topotecan, hydroxycarbamide, Miltefosine, Pentostatin, Pegaspargase, Exemestane, thunder song azoles, good fortune
It is Mei Tan, mycophenolate, β-lapachol, podophyllotoxin, peg-interferon α-2b, polyethylene glycol, cytokine antagonist, thin
Born of the same parents' mitogen inhibitor, COX-2 inhibitors, angiopeptin, the monoclonal antibody for inhibiting muscle cell multiplication, bFGF antagonism
Agent, probucol, prostaglandin, 1- hydroxyl -11- methoxyl group canthin-6-one, Scopoletin, nitric oxide donors, Ji Wusi
Alcohol tetranitrate and sydnone imines, tamoxifen, staurosporin, beta estradiol, alpha-estradiol, estriol, oestrone, alkynes are female
Alcohol, Medroxyprogesterone, cycloprovera, oestradiol benzoate, tranilast, rabdosiaexcisa C prime and it is other be used for cancer
Terpenoid, Verapamil, tyrosine kinase inhibitor, 6- Alpha-hydroxy-taxol, taxotere, the albumin mating type Japanese yew of therapy
Alcohol, Mofebutazone, lonazolac, lidocaine, Ketoprofen, mefenamic acid, piroxicam, Meloxicam, penicillamine, hydroxy chloride
Quinoline, sodium aurothiomalate, Oxaceprol, cupreol, myrtecaine, polidocanol, Nonivamide, Levomenthol, ellipticine,
Demecolcine, B cytochalasin B A-E, Yin Dannuoxin, nocodazole, bacitracin, vitronectin receptor antagonist, nitrogen Zhuo Si
Spit of fland, guanylate cyclase stimulant, metalloproteinases -1 and metalloproteinases -2 tissue depressant, free nucleic acid, be incorporated to disease
Nucleic acid, DNA and ribonucleic acid fragments, plasminogen activator inhibitor -1, plasminogen in malicious disseminator
Activating factor inhibitors -2, antisense oligonucleotides, vascular endothelial growth factor receptor inhibitors, insulin-like growth factor, antibiotic
Activating agent, cephalo azanol benzyl in group, Cefazolin, Cefaclor, cefotaxime, tobramycin, gentamicin, mould
Element, dicloxacillin, oxacillin, sulfanilamide (SN), metronidazole, Enoxaparin, heparin, hirudin, D-Phe-Pro-essence ammonia
Acid-chloromethane ketone, nucleoprotamine, prourokinase, streptokinase, warfarin, urokinase, vasodilator, Dipyridamole, bent ground
That, nitroprusside, the growth factor antagonist in blood platelet source, triazolo pyrimidine, salad be quick, acetylcholinesterase inhibitor, card
Top's benefit, Cilazapril, lisinopril, enalapril, Losartan, sulfoprotein enzyme inhibitor, prostacyclin, Vapiprost,
Interferon-' alpha ', interferon beta and interferon gamma, histamine antagonist, thrombocytin blocking agent, apoptosis inhibitor, apoptosis regulation
Agent, Halofuginone, nifedipine, tocopherol, tranilast, molsidomine, tea polyphenols, L-Epicatechin gallate, epi-nutgall
Catechin and gallate, leflunomide, Etanercept, sulfasalazine, tetracycline, triamcinolone, mutamycin, Proca
Because of the steroids that amine, retinoic acid, quinindium, disopyramide, Flecainide, Propafenone, Sotalol, natural and synthesis obtain, fall
Ground is taken root toxin A, Inonotus obliquus alcohol, Ma Kuisang glycosides A, Jia Lajina glycosides, Man Songning, streblus asper glycosides, hydrocortisone, times his rice
Pine, dexamethasone, on-steroidal substance, fenoprofen, brufen, Indomethacin, naproxen, phenylbutazone, antivirotic, Ah former times
Luo Wei, Ganciclovir, Zidovudine, clotrimazole, Flucytosine, griseofulvin, ketoconazole, Miconazole, nystatin, spy compare naphthalene
Sweet smell, antiprotozoan agent, chloroquine, Mefloquine, quinine, natural terpenoid, hippocampus calcium albumen, 14- dehydrogenation root of Beijing euphorbia toxin, euphorbin, the root of Beijing euphorbia
Toxin, 17- hydroxyl root of Beijing euphorbia toxin, Indian Epimeredi Herb lactone, 4,7- oxygroup ring anisomelic acid, class baccharine B1, B2, B3 and B7, soil
Fritillaria glycosides, anti-dysentery yatanoside C, yatanoside N and P, different deoxidation elephants-foot element, white flower elephants-foot element A and B, Jiang Huasu A, B, C
With D, ursolic acid, Xipi his theobromine A, iso- Iris germanica aldehyde, Variable-leaved Mayten alcohol, Rabdosia amethystoides penta element A, Amethystoidin A and perfume (or spice)
Tea dish B prime, long tube plectranthin B, chrysanthemum Rabdosia amethystoides C prime, Ka meter Bao element, Rui Jiluoer, triptolide, cymarin, original
Anemonin, chlorination Che Libu element, very heavy rattan element A and B, Dihydronitidine, Nitidine Chloride, the pregnant diene-of 12- beta-hydroxy
3,20- diketone, helenalin, indicine, indicine-N- oxide, lasiocarpine, Inonotus obliquus alcohol, podophyllotoxin
Element, justicidin A and B, La Ruiting, wild paulownia alkali, wild paulownia chromanol, isobutyryl open country paulownia chromanol, maytansine, Lake are auspicious
Glad, Ma Jiting, water ghost any of several broadleaf plants alkali, liriodendrin, oxoushinsunine, periplocin A, deoxidation psorospermin, nine section lignins, castor-oil plant
Toxin A, sanguinarine, houseful wheat acid, methyl sorbifolin, Rutaceae chromone, this for Zuo Pulin, dihydro Wu Sabarenxin,
Hydroxyl usambarine, five amine of strychnic alkali, the general woods of strychnic alkali, usambarine, Wu Sabarenxin, liriodendrin, daphnoretin,
Lariciresinol, methoxyl group lariciresinol, syringaresinol, sirolimus, biolimus A9, Elidel, everolimus,
Azoles Luo Mosi, tacrolimus, albumin mating type sirolimus, nap- sirolimus, Fasudil, Epothilones, growth suppression
Element, troleandomycin, Simvastatin, rosuvastatin, vinblastine, vincristine, eldisine, replaces Ni Bo at roxithromycin
It is glycosides, Vinorelbine, Trofosfamide, Treosulfan, Temozolomide, phosphinothioylidynetrisaziridine, vitamin A acid, spiramvcin, umbelliferone, deacetylated
One of Ji Weisi rice grain pattern A, dimension department rice grain pattern A and B, zeorin or a variety of.
Priority Applications (1)
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PCT/CN2019/000065 WO2019196519A1 (en) | 2018-04-12 | 2019-04-12 | Balloon for bifurcation lesion in biological vessel, use thereof and surgical method |
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CN201810324413 | 2018-04-12 | ||
CN2018103244133 | 2018-04-12 | ||
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CN201811315832 | 2018-11-07 |
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CN201822109606.5U Active CN210159073U (en) | 2018-04-12 | 2018-12-14 | Balloon component for bifurcation lesion of biological body pipeline |
CN201822109609.9U Active CN209713964U (en) | 2018-04-12 | 2018-12-14 | A kind of sacculus for biological body vessel bifurcated lesions |
CN201811539049.9A Active CN109731206B (en) | 2018-04-12 | 2018-12-14 | Balloon for bifurcation lesion of biological body pipeline and application thereof |
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CN201822109606.5U Active CN210159073U (en) | 2018-04-12 | 2018-12-14 | Balloon component for bifurcation lesion of biological body pipeline |
CN201822109609.9U Active CN209713964U (en) | 2018-04-12 | 2018-12-14 | A kind of sacculus for biological body vessel bifurcated lesions |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113546286A (en) * | 2021-08-12 | 2021-10-26 | 安徽通灵仿生科技有限公司 | Multi-balloon catheter assembly for interventional treatment of coronary bifurcation lesions |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2021132141A1 (en) * | 2019-12-26 | 2021-07-01 | 株式会社グッドマン | Balloon catheter |
CN114748701B (en) * | 2022-03-22 | 2023-05-16 | 乐普(北京)医疗器械股份有限公司 | Drug coating, drug balloon, preparation method and application of drug balloon |
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CN101987222A (en) * | 2010-12-03 | 2011-03-23 | 上海硕创生物医药科技有限公司 | Catheter with strip saccule on surface |
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CN206792786U (en) * | 2016-12-29 | 2017-12-26 | 上海康德莱医疗器械股份有限公司 | A kind of Kissing balloon operation special pressure pipe |
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- 2018-12-14 CN CN201822109606.5U patent/CN210159073U/en active Active
- 2018-12-14 CN CN201822109609.9U patent/CN209713964U/en active Active
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US20120283635A1 (en) * | 2010-01-22 | 2012-11-08 | Concept Medical Research Private Limited | Method and a balloon catheter assembly for treating bifurcation lesions |
CN101785900A (en) * | 2010-03-10 | 2010-07-28 | 成都维德医疗器械有限责任公司 | Medicinal balloon catheter and preparation method thereof |
CN101987222A (en) * | 2010-12-03 | 2011-03-23 | 上海硕创生物医药科技有限公司 | Catheter with strip saccule on surface |
CN102525609A (en) * | 2012-03-09 | 2012-07-04 | 上海凯利泰医疗科技股份有限公司 | Double-sacculus catheter structure |
CN103948972A (en) * | 2014-05-04 | 2014-07-30 | 广东博迈医疗器械有限公司 | Expandable saccule provided with modified coating on surface and preparation process of expandable saccule |
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CN113546286A (en) * | 2021-08-12 | 2021-10-26 | 安徽通灵仿生科技有限公司 | Multi-balloon catheter assembly for interventional treatment of coronary bifurcation lesions |
Also Published As
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CN210159073U (en) | 2020-03-20 |
WO2019196519A1 (en) | 2019-10-17 |
CN209713964U (en) | 2019-12-03 |
CN109731206B (en) | 2020-08-11 |
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