CN109730968A - Photosensitizer and preparation method thereof - Google Patents
Photosensitizer and preparation method thereof Download PDFInfo
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- CN109730968A CN109730968A CN201910199470.8A CN201910199470A CN109730968A CN 109730968 A CN109730968 A CN 109730968A CN 201910199470 A CN201910199470 A CN 201910199470A CN 109730968 A CN109730968 A CN 109730968A
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- photosensitizer
- photosensitive agent
- agent carrier
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Abstract
The invention discloses a kind of for photo-thermal, the photosensitizer of optical dynamic therapy and immune combination therapy, is related to nanosecond medical science field.It is with poly-dopamine nano particle (Polydopamine, PDA) it is core, wraps up one layer upper conversion nano shell (Upconversion nanoparticle, UCNP), PDA@UCNP core-shell structure is formed, photosensitive molecular (Ce6) can be loaded by polyethylene glycol.The nano-probe has good biocompatibility and stability, and energy while heat production and singlet oxygen under the excitation of single 980nm near infrared light realize photo-thermal and photodynamic combination therapy.
Description
Technical field
The present invention relates to a kind of photosensitizers, and in particular to converts photosensitizer on a kind of nanoparticle.
Background technique
Oncotherapy technology mainly includes operation excision, chemotherapy, radiation treatment and optical therapeutic etc..Wherein, optics is controlled
Treatment mainly has photo-thermal therapy and optical dynamic therapy.Photo-thermal therapy is using the material with photothermal conversion, in swashing for external light source
Give the method that cancer cell can be killed with the thermal energy of generation.And optical dynamic therapy be excited under the action of external light source it is photosensitive
Agent generates active oxygen and then leads to the treatment method of cellular damage and necrosis.Although photo-thermal therapy and optical dynamic therapy have obtained extensively
General research and report, but tumour has very strong heterogeneous and its complicated microenvironment, general photo-thermal therapy and light power
Treatment is learned to be difficult to be completely eliminated.
Photo-thermal and photodynamics combinational therapeutic methods can effectively overcome the heterogeneity of tumour cell, be demonstrate,proved by scientists
It is real.But now optical joint treatment mostly be all with shorter-wavelength light excitation or multi-wavelength's excitation light source, reduce and control
The effect and operability for the treatment of.And the core of photo-thermal and optical dynamic therapy is exactly photosensitizer.Photosensitizer now is only used for light
Dynamic therapy, and two aspect of photo-thermal and optical dynamic therapy can not be had both.
Therefore, designing a kind of photo-thermal and photosensitizer for photodynamic therapy has very important research significance and application value.
Summary of the invention
The object of the present invention is to provide a kind of photosensitive agent carriers and preparation method thereof, to solve existing photosensitive agent carrier not
The technical issues of capable of supporting photo-thermal therapy.
It is a further object of the present invention to provide a kind of photosensitizers and preparation method thereof, do not have to solve existing photosensitizer
The technical issues of function of photo-thermal therapy.
In order to achieve the above-mentioned object of the invention, one aspect of the present invention provides a kind of photosensitive agent carrier, the photosensitive agent carrier
For nanoscale core-shell structure, the core-shell structure includes nucleome and the shell for being coated on the nucleome, and the nucleome is poly- more
Bar amine nano particle, the shell includes Gd ionic compound, Yb ionic compound and Er ionic compound.
The molar ratio of the preferably described Gd element, Yb element and Er element is 70-80%:15-20%:1-5%.
Preferably, the partial size of the photosensitive agent carrier is 120-160nm；
The nucleome partial size is 50-70nm；
The shell with a thickness of 70-90nm.
Another aspect of the present invention provides a kind of photosensitizer, including carrier and the photosensitizer function being incorporated on the carrier
Ingredient, the carrier are the photosensitive agent carrier, and the photosensitizer functional component is upper conversion photosensitizer.
Preferably, the photosensitizer functional component and carrier ratio 10%-15%.
Preferably, the upper conversion photosensitizer functional component includes photosensitizer Ce6 molecule.
Another aspect of the invention provides a kind of preparation method of photosensitive agent carrier, includes the following steps:
Rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
Rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer.
Another aspect of the invention provides a kind of preparation method of photosensitizer, which comprises the steps of:
Rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
Rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer.
Further aspect of the present invention provides a kind of preparation method of photosensitizer, which comprises the steps of:
Rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
Rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer
The modification activities group on the up-conversion luminescence layer；
Photosensitizer is loaded on the up-conversion luminescence layer for being modified with active group.
Preferably, the active group includes any one or more in hydroxyl, carboxyl and amino.
Application of the photosensitizer in terms of preparing photo-thermal optical dynamic therapy medicine.
Compared with existing product, photosensitizer carrier structure of the invention is simple, but can have both photo-thermal and optical dynamic therapy
Two kinds of functions.On the one hand the poly-dopamine nanometer core photo-thermal effect chosen is very significant, so that the light of the photosensitive agent carrier
Hot property is prominent；On the other hand long wavelength's low energy can be made by choosing up-conversion nanoparticles as shell, penetrability by force close
Infrared light is changed into the high short-wavelength light of energy to activate optical dynamic therapy.
The photosensitizer also has two kinds of function of photo-thermal and optical dynamic therapy due to using the photosensitive agent carrier
Can, make full use of luminous energy to the dual destruction in position in need for the treatment of, better effect.And also there is light thermal property outstanding, it is excellent
Elegant biological tissue's penetrability, and it is lower according to tissue injury compared to short-wavelength light.
The preparation method of the photosensitive agent carrier, step is simplified, easy to operate, also the solvent high without practical toxicity,
It does not generate and pollutes high by-product, selected reaction conversion is simple, and yield is high, has very high practicability.
On the one hand the preparation method of the photosensitizer has step and simplifies, operate due to using the photosensitive agent carrier
Simply, experimentation green；On the other hand also very simple is effective for the means of loading photosensitizer functional component, total preparation
Be it is succinct efficiently, green is harmless.
Therefore photosensitizer of the present invention can be advantageously applied in photo-thermal and optical dynamic therapy.
Detailed description of the invention
The synthesis step schematic diagram of photosensitive agent carrier described in Fig. 1 embodiment of the present invention；
Fig. 2 is the scanning electron microscope (SEM) photograph of poly-dopamine of embodiment of the present invention nanoparticle a and photosensitive agent carrier b；
The photo-thermal effect of Fig. 3 PDA@UCNP provided in an embodiment of the present invention evaluates figure；
Emission spectrum that Fig. 4 is PDA@UCNP provided in an embodiment of the present invention under the excitation of 980nm near infrared light and photosensitive
The abosrption spectrogram of molecule.
Specific embodiment
In order to which technical problems, technical solutions and advantageous effects to be solved by the present invention are more clearly understood, below in conjunction with
Embodiment, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only used to explain
The present invention is not intended to limit the present invention.
On the one hand the embodiment of the present invention provides a kind of photosensitive agent carrier, the photosensitive agent carrier is nanoscale nucleocapsid knot
Structure, the core-shell structure include nucleome and the shell for being coated on the nucleome, and the nucleome is poly-dopamine nano particle, described
Shell includes Gd ionic compound, Yb ionic compound and Er ionic compound.Photosensitive agent carrier of the invention is using light
Hot nano material has very strong light thermal property, rather than as other photosensitive agent material nucleomes are also that the upper conversion used is received
Rice material.Therefore have a kind of light thermal property more.And the absorbing wavelength of the rare earth element used is near infrared region, and by upper
Conversion converts the near infrared light of two parts of long wavelengths to 500 nanometers of light below that wavelength is half, high energy excited singlet
Oxygen, while generating stronger photo-thermal effect.The two cooperates, and achievees the purpose that eliminate lesion.
The molar ratio of the Gd element, Yb element and Er element is 70-80%:15-20%:1-5%.On the one hand polynary
The absorption region that the doping of element can make becomes wide；Two are all not quite similar come the absorption intensity emissive porwer due to various elements, because
This adjusts dosage to balance its bulk strength.
The partial size of the photosensitive agent carrier is 120-160nm；
The nucleome partial size is 50-70nm；
The shell with a thickness of 70-90nm.
Lesser partial size can more fully absorb energy transmission energy, be limited to process conditions, take partial size described in condition
Range.
On the other hand the embodiment of the present invention provides a kind of preparation method of photosensitive agent carrier, include the following steps:
S01: rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
S02: rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer.
In S01 of the embodiment of the present invention, realize rare earth carbonic acid hydrogen-oxygen nitride layer package be will comprising rare earth element salt it is molten
Solution is added poly-dopamine nano particle and flows back with the readily volatilized substance heat together of alkalinity, obtains rare earth carbonic acid hydrogen-oxygen nitride layer packet
The poly-dopamine particle wrapped up in.
In S02 of the embodiment of the present invention, fluoride and hydrofluoric acid is added in the specific rare earth carbonic acid hydrogen-oxygen nitride layer, is formed
The fluoride of rare earth element.
The another aspect of the embodiment of the present invention provides a kind of photosensitizer, including carrier and is incorporated into photosensitive on the carrier
Agent functional component, carrier are above-mentioned photosensitive agent carrier, and the photosensitizer functional component is upper conversion photosensitizer.
The photosensitizer functional component and carrier ratio are 10%-15%.Light could be allowed by needing enough photosensitive agent carriers
Quick dose of Function is complete, and it will cause wastes for excessive amount, therefore chooses this range scale.
The upper conversion photosensitizer functional component includes photosensitizer Ce6 molecule.The absorbing wavelength of these types of photosensitizer with it is dilute
Launch wavelength registration after converting on earth elements is higher, therefore chooses these types of photosensitizer.
Further aspect of the present invention provides a kind of preparation method of photosensitizer, which comprises the steps of:
S01: rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
S02: rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer.
S03: the modification activities group on the up-conversion luminescence layer；
S04: photosensitizer is loaded on the up-conversion luminescence layer for being modified with active group.
Active group described in step of the embodiment of the present invention S03 and S04 includes any one in hydroxyl, carboxyl and amino
Or it is a variety of.The specific connection compound for choosing the active group with there are two types of, first rare earth element in the connection of selectivity, then leads to
It crosses another group and connect completion loading with photosensitizer.
The photosensitizer, which can be used in, prepares photo-thermal optical dynamic therapy medicine.Some auxiliary materials can be specifically added, are made
Effect it is more preferable.
(wherein the step of front is exactly photosensitive agent carrier and preparation method thereof to photosensitizer and preparation method thereof, just no longer single
It solely lists).
Embodiment 1
The synthesis step of photosensitizer is as shown in Figure 1.
In the mixed solution of the alcohol-water (1:1) of 20mL, addition 1mL rare earth element ratio is 78%:20%:2%
(GdCl3:YbCl3:ErCl3) solution, magnetic agitation 10-30min formed clear solution.The 3mg synthesized in step (1) is added
Poly-dopamine powder of nanometric particles, ultrasonic 10-30min.Solution is then flowed back to 6h at 90 DEG C to get PDA Gd, Yb, Er is arrived
(OH)CO3Nano particle.
By PDA@Gd, Yb, Er (OH) CO3Nano particle is scattered in 5mL water, and 5mL ethylene glycol and 20mg NaF is added, stirs
10min is mixed, is transferred in reaction kettle, handles 8h under the conditions of 180 DEG C.
It will be scattered in 5-15mL ethanol-water solution (1:1) after obtained nano particle centrifuge washing, 0.1- be added
0.5mL 1mol/L NaF and 0.1-0.5mL 3mol/L HF solution stirs 10-30min, handles under the conditions of 100-180 DEG C
4-12h, centrifugation obtain PDA@UCNP nano particle.
Fig. 2 b show the pattern of the poly-dopamine nano particle (PDA@UCNP) of obtained up-conversion luminescence layer cladding
Figure.Fig. 3 be up-conversion luminescence layer cladding poly-dopamine nano particle (PDA@UCNP) in 980nm near infrared light with 1W/cm2Function
Photo-thermal under rate excitation, which heats up, schemes.
The PDA@UCNP and multijaw polyethylene glycol (mPEG-PMHC18) 1:1 in mass ratio that synthesize in (2) are mixed
For 24 hours, it washs, obtains PDA@UCNP-PEG nano particle.
Photosensitive molecular Ce6 ethanol solution is added, stirs 12h, centrifugation obtains PDA@UCNP-PEG/Ce6 nano-probe.
Fig. 4 is that the poly-dopamine nano particle (PDA@UCNP) of up-conversion luminescence layer cladding is excited in 980nm near infrared light
Under emission spectrum and photosensitive molecular (Ce6) abosrption spectrogram.
Embodiment 2
In the mixed solution of the alcohol-water (1:1) of 20mL, addition 1mL rare earth element ratio is 60%:20%:20%
(GdCl3:YbCl3:ErCl3) solution, magnetic agitation 10-30min formed clear solution.The 3mg synthesized in step (1) is added
Poly-dopamine powder of nanometric particles, ultrasonic 10-30min.Solution is then flowed back to 6h at 90 DEG C to get PDA Gd, Yb, Er is arrived
(OH)CO3Nano particle.
By PDA@Gd, Yb, Er (OH) CO3Nano particle is scattered in 5mL water, and 5mL ethylene glycol and 20mg NaF is added, stirs
10min is mixed, is transferred in reaction kettle, handles 8h under the conditions of 180 DEG C.
It will be scattered in 5-15mL ethanol-water solution (1:1) after obtained nano particle centrifuge washing, 0.1- be added
0.5mL 1mol/L NaF and 0.1-0.5mL 3mol/L HF solution stirs 10-30min, handles under the conditions of 100-180 DEG C
4-12h, centrifugation obtain PDA@UCNP nano particle.
Fig. 2 b show the pattern of the poly-dopamine nano particle (PDA@UCNP) of obtained up-conversion luminescence layer cladding
Figure.Fig. 3 be up-conversion luminescence layer cladding poly-dopamine nano particle (PDA@UCNP) in 980nm near infrared light with 1W/cm2Function
Photo-thermal under rate excitation, which heats up, schemes.
The PDA@UCNP and multijaw polyethylene glycol (mPEG-PMHC18) 1:1 in mass ratio that synthesize in (2) are mixed
For 24 hours, it washs, obtains PDA@UCNP-PEG nano particle.
Photosensitive molecular Ce6 ethanol solution is added, stirs 12h, centrifugation obtains PDA@UCNP-PEG/Ce6 nano-probe.
Embodiment 3
In the mixed solution of the alcohol-water (1:1) of 20mL, addition 1mL rare earth element ratio is 78%:12%:10%
(GdCl3:YbCl3:ErCl3) solution, magnetic agitation 10-30min formed clear solution.The 3mg synthesized in step (1) is added
Poly-dopamine powder of nanometric particles, ultrasonic 10-30min.Solution is then flowed back to 6h at 90 DEG C to get PDA Gd, Yb, Er is arrived
(OH)CO3Nano particle.
By PDA@Gd, Yb, Er (OH) CO3Nano particle is scattered in 5mL water, and 5mL ethylene glycol and 20mg NaF is added, stirs
10min is mixed, is transferred in reaction kettle, handles 8h under the conditions of 180 DEG C.
It will be scattered in 5-15mL ethanol-water solution (1:1) after obtained nano particle centrifuge washing, 0.1- be added
0.5mL 1mol/L NaF and 0.1-0.5mL 3mol/L HF solution stirs 10-30min, handles under the conditions of 100-180 DEG C
4-12h, centrifugation obtain PDA@UCNP nano particle.
Fig. 2 b show the pattern of the poly-dopamine nano particle (PDA@UCNP) of obtained up-conversion luminescence layer cladding
Figure.Fig. 3 be up-conversion luminescence layer cladding poly-dopamine nano particle (PDA@UCNP) in 980nm near infrared light with 1W/cm2Function
Photo-thermal under rate excitation, which heats up, schemes.
The PDA@UCNP and multijaw polyethylene glycol (mPEG-PMHC18) 1:1 in mass ratio that synthesize in (2) are mixed
For 24 hours, it washs, obtains PDA@UCNP-PEG nano particle.
Photosensitive molecular Ce6 ethanol solution is added, stirs 12h, centrifugation obtains PDA@UCNP-PEG/Ce6 nano-probe.
Claims (10)
1. a kind of photosensitive agent carrier, the photosensitive agent carrier is nanoscale core-shell structure, the core-shell structure include nucleome and
It is coated on the shell of the nucleome, it is characterised in that: the nucleome is poly-dopamine nano particle, and the shell includes Gd ion
Compound, Yb ionic compound and Er ionic compound.
2. photosensitive agent carrier according to claim 1, it is characterised in that: the Gd element, Yb element and Er element rub
Your ratio is 70-80%:15-20%:1-5%.
3. photosensitive agent carrier according to claim 1, it is characterised in that:
The partial size of the photosensitive agent carrier is 120-160nm；
The nucleome partial size is 50-70nm；
The shell with a thickness of 70-90nm.
4. a kind of photosensitizer, including carrier and the photosensitizer functional component being incorporated on the carrier, it is characterised in that: the load
Body is any photosensitive agent carrier of claim 1-3, and the photosensitizer functional component is upper conversion photosensitizer.
5. photosensitizer according to claim 4, it is characterised in that: the photosensitizer functional component is with carrier ratio
10%-15%.
6. photosensitizer according to claim 3 or 4, it is characterised in that: the upper conversion photosensitizer functional component includes light
Quick dose of Ce6 molecule.
7. a kind of preparation method of photosensitive agent carrier, which comprises the steps of:
Rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
Rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer.
8. a kind of preparation method of photosensitizer, which comprises the steps of:
Rare earth carbonic acid hydrogen-oxygen nitride layer is wrapped up on poly-dopamine nano particle；
Rare earth carbonic acid hydrogen-oxygen nitride layer is converted into up-conversion luminescence layer；
The modification activities group on the up-conversion luminescence layer；
Photosensitizer is loaded on the up-conversion luminescence layer for being modified with active group.
9. the preparation method of photosensitizer according to claim 8, it is characterised in that: the active group includes hydroxyl, carboxylic
Any one or more in base and amino.
10. application of the photosensitizer according to claim 4 in terms of preparing photo-thermal optical dynamic therapy medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110193083A (en) * | 2019-03-26 | 2019-09-03 | 深圳大学 | Anti-tumor drug and preparation method thereof |
| CN114504727A (en) * | 2022-04-02 | 2022-05-17 | 广州纳丽生物科技有限公司 | Polydopamine photothermal conversion effect microneedle and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104017581A (en) * | 2014-06-18 | 2014-09-03 | 东南大学 | Photothermal conversion nanometer material as well as preparation method and application method thereof |
| CN106432594A (en) * | 2016-09-29 | 2017-02-22 | 温州生物材料与工程研究所 | Light- heat-magnetism multi-responsive microgel and preparation method thereof |
| US9770418B2 (en) * | 2013-01-07 | 2017-09-26 | Bar-Ilan University | Dopamine nanocapsules and uses thereof |
| CN109248158A (en) * | 2018-11-21 | 2019-01-22 | 深圳大学 | Photosensitizer and preparation method thereof |
| CN109364245A (en) * | 2018-09-04 | 2019-02-22 | 中山大学 | A kind of poly-dopamine nanometer diagnosis and treatment agent and preparation method thereof |
-
2019
- 2019-03-15 CN CN201910199470.8A patent/CN109730968A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9770418B2 (en) * | 2013-01-07 | 2017-09-26 | Bar-Ilan University | Dopamine nanocapsules and uses thereof |
| CN104017581A (en) * | 2014-06-18 | 2014-09-03 | 东南大学 | Photothermal conversion nanometer material as well as preparation method and application method thereof |
| CN106432594A (en) * | 2016-09-29 | 2017-02-22 | 温州生物材料与工程研究所 | Light- heat-magnetism multi-responsive microgel and preparation method thereof |
| CN109364245A (en) * | 2018-09-04 | 2019-02-22 | 中山大学 | A kind of poly-dopamine nanometer diagnosis and treatment agent and preparation method thereof |
| CN109248158A (en) * | 2018-11-21 | 2019-01-22 | 深圳大学 | Photosensitizer and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| LIU, B ET AL.: ""Multifunctional UCNPs@PDA-ICG nanocomposites for u-pconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy"", 《JOURNAL OF MATERIALS CHEMISTRY B》 * |
| ZHANG, DA ET AL.: ""Chlorin e6 conjugated poly (dopamine) nanospheres as PDT/PTT dual-modal therapeutic agents for enhanced cancer therapy"", 《ACS APPLIED MATERIALS & INTERFACES 》 * |
| 陈小兰等: ""NaYF4:Gd, Yb, Er/PEI上转换纳米颗粒的合成及其在PDT和MRI中的应用"", 《玉林师范学院学报》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110193083A (en) * | 2019-03-26 | 2019-09-03 | 深圳大学 | Anti-tumor drug and preparation method thereof |
| CN114504727A (en) * | 2022-04-02 | 2022-05-17 | 广州纳丽生物科技有限公司 | Polydopamine photothermal conversion effect microneedle and preparation method thereof |
| CN114504727B (en) * | 2022-04-02 | 2022-08-23 | 广州纳丽生物科技有限公司 | Polydopamine photothermal conversion effect microneedle and preparation method thereof |
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Application publication date: 20190510 |